uracil mustard 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 2795 66-75-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • uracil mustard
  • aminouracil mustard
  • chlorethaminacil
  • demethyldopan
  • desmethyldopan
  • uracil nitrogen mustard
  • uramustin
  • uramustine
Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
  • Molecular weight: 252.10
  • Formula: C8H11Cl2N3O2
  • CLOGP: 0.60
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 61.44
  • ALOGS: -2.28
  • ROTB: 5
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 1.32 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 13, 1962 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AD08 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrosoureas
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic lymphoid leukemia, disease indication 92814006
Chronic myeloid leukemia indication 92818009 DOID:8552
Polycythemia vera indication 109992005
Non-Hodgkin's lymphoma indication 118601006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 2.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018098 VUID
N0000146436 NUI
D06265 KEGG_DRUG
4018098 VANDF
C0041920 UMLSCUI
CHEBI:9884 CHEBI
CHEMBL1488 ChEMBL_ID
DB00791 DRUGBANK_ID
D014499 MESH_DESCRIPTOR_UI
6194 PUBCHEM_CID
7621 IUPHAR_LIGAND_ID
1351 INN_ID
W7KQ46GJ8U UNII
10996 RXNORM
3099 MMSL
5655 MMSL
d01340 MMSL
002634 NDDF
17243005 SNOMEDCT_US

Pharmaceutical products:

None