tulobuterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| bronchodilators, phenethylamine derivatives | 2782 | 41570-61-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1.60 | mg | Inhal.aerosol |
| 4 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 48 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Decreased appetite | 32.36 | 32.15 | 25 | 579 | 166367 | 34789960 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Upper respiratory tract inflammation | 39.30 | 24.98 | 10 | 1433 | 4025 | 79738920 |
| Pneumonia aspiration | 37.41 | 24.98 | 20 | 1423 | 66947 | 79675998 |
| Interstitial lung disease | 34.94 | 24.98 | 23 | 1420 | 112577 | 79630368 |
| Hepatic function abnormal | 33.06 | 24.98 | 19 | 1424 | 73088 | 79669857 |
| Oesophageal dilatation | 27.06 | 24.98 | 5 | 1438 | 450 | 79742495 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03AC11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists |
| ATC | R03CC11 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pulmonary emphysema | indication | 87433001 | |
| Asthma | indication | 195967001 | DOID:2841 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.76 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | GPCR | AGONIST | DRUG LABEL | SCIENTIFIC LITERATURE | |||||
| Beta-2 adrenergic receptor | GPCR | Kd | 6.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01362 | KEGG_DRUG |
| C0077497 | UMLSCUI |
| CHEBI:93856 | CHEBI |
| CHEMBL1159717 | ChEMBL_ID |
| DB12248 | DRUGBANK_ID |
| 5606 | PUBCHEM_CID |
| C010809 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4564 | INN_ID |
| 56776-01-3 | SECONDARY_CAS_RN |
| 591I9SU0F7 | UNII |
| 235841 | RXNORM |
| 004061 | NDDF |
| 004062 | NDDF |
| 349929009 | SNOMEDCT_US |
| 397178007 | SNOMEDCT_US |
| CHEMBL1256478 | ChEMBL_ID |
Pharmaceutical products:
None