tulobuterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	2782	41570-61-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hokunalin
tulobuterol
(+/-)-tulobuterol
tulobuterol hydrochloride
tulobuterol HCl

Molecular weight: 227.73
Formula: C12H18ClNO
CLOGP: 2.53
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 32.26
ALOGS: -2.79
ROTB: 4

Drug dosage:

Dose	Unit	Route
1.60	mg	Inhal.aerosol
4	mg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	48 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70	43
kinase-selectivity-class	AXL,BRAF,EIF2AK3,EPHB4,GRK2,PDK4	6
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Upper respiratory tract inflammation	33.73	32.28	7	704	2665	90625071

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	38.91	33.27	18	669	50060	42570588
Decreased appetite	37.08	33.27	28	659	193109	42427539

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Upper respiratory tract inflammation	56.02	27.41	13	1628	4358	110583300
Pneumonia aspiration	46.17	27.41	23	1618	81210	110506448
Interstitial lung disease	34.61	27.41	23	1618	139311	110448347
Hepatic function abnormal	33.02	27.41	19	1622	89276	110498382
Pneumonia	28.05	27.41	48	1593	876666	109710992

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03AC11	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists
ATC	R03CC11	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists
MeSH PA	D000318	Adrenergic beta-Agonists
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D019141	Respiratory System Agents

Related Drugs by ATC class:

R03AC Selective beta-2-adrenoreceptor agonists 17 drugs

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R03CC Selective beta-2-adrenoreceptor agonists 14 drugs

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Pulmonary emphysema	indication	87433001
Asthma	indication	195967001	DOID:2841

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.76	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	AGONIST				DRUG LABEL	SCIENTIFIC LITERATURE
Beta-2 adrenergic receptor	GPCR		ADRB2_BOVIN		Kd	6.89		CHEMBL

External reference:

ID	Source
D01362	KEGG_DRUG
C0077497	UMLSCUI
CHEBI:749159	CHEBI
CHEMBL1159717	ChEMBL_ID
DB12248	DRUGBANK_ID
CHEMBL1256478	ChEMBL_ID
5606	PUBCHEM_CID
C010809	MESH_SUPPLEMENTAL_RECORD_UI
4564	INN_ID
56776-01-3	SECONDARY_CAS_RN
591I9SU0F7	UNII
235841	RXNORM
004061	NDDF
004062	NDDF
349929009	SNOMEDCT_US
397178007	SNOMEDCT_US
591I9SU0F7	INXIGHT DRUGS

Pharmaceutical products:

None