tulobuterol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 2782 41570-61-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hokunalin
  • tulobuterol
  • (+/-)-tulobuterol
  • tulobuterol hydrochloride
  • tulobuterol HCl
  • Molecular weight: 227.73
  • Formula: C12H18ClNO
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -2.79
  • ROTB: 4

Drug dosage:

DoseUnitRoute
1.60 mg Inhal.aerosol
4 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 48 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 83.37 28.39 45 1384 91497 46593136
Abnormal behaviour 42.68 28.39 18 1411 21040 46663593
Interstitial lung disease 31.65 28.39 20 1409 53929 46630704
Altered state of consciousness 28.43 28.39 14 1415 23334 46661299

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Abnormal behaviour 83.87 29.11 36 1545 25587 29925310
Interstitial lung disease 64.92 29.11 40 1541 60157 29890740
Hepatic function abnormal 48.05 29.11 29 1552 41916 29908981
Asthma 38.82 29.11 24 1557 36150 29914747

Pharmacologic Action:

SourceCodeDescription
ATC R03AC11 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03CC11 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST DRUG LABEL SCIENTIFIC LITERATURE
Beta-2 adrenergic receptor GPCR Kd 6.89 CHEMBL

External reference:

IDSource
D01362 KEGG_DRUG
56776-01-3 SECONDARY_CAS_RN
C0077497 UMLSCUI
CHEBI:93856 CHEBI
CHEMBL1159717 ChEMBL_ID
CHEMBL1256478 ChEMBL_ID
C010809 MESH_SUPPLEMENTAL_RECORD_UI
4564 INN_ID
DB12248 DRUGBANK_ID
591I9SU0F7 UNII
5702285 PUBCHEM_CID
235841 RXNORM
004061 NDDF
004062 NDDF
349929009 SNOMEDCT_US
397178007 SNOMEDCT_US

Pharmaceutical products:

None