tulobuterol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 2782 41570-61-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hokunalin
  • tulobuterol
  • (+/-)-tulobuterol
  • tulobuterol hydrochloride
  • tulobuterol HCl
  • Molecular weight: 227.73
  • Formula: C12H18ClNO
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -2.79
  • ROTB: 4

Drug dosage:

DoseUnitRoute
1.60 mg Inhal.aerosol
4 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 48 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 79.83 31.35 45 1446 108927 53238648
Abnormal behaviour 43.60 31.35 18 1473 21848 53325727
Altered state of consciousness 31.86 31.35 15 1476 24821 53322754
Interstitial lung disease 31.79 31.35 20 1471 58602 53288973

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Abnormal behaviour 84.03 28.05 36 1617 26430 32485443
Interstitial lung disease 63.46 28.05 40 1613 64961 32446912
Hepatic function abnormal 49.83 28.05 30 1623 44810 32467063
Asthma 35.30 28.05 24 1629 44041 32467832

Pharmacologic Action:

SourceCodeDescription
ATC R03AC11 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
ATC R03CC11 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS FOR SYSTEMIC USE
Selective beta-2-adrenoreceptor agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST DRUG LABEL SCIENTIFIC LITERATURE
Beta-2 adrenergic receptor GPCR Kd 6.89 CHEMBL

External reference:

IDSource
D01362 KEGG_DRUG
56776-01-3 SECONDARY_CAS_RN
C0077497 UMLSCUI
CHEBI:93856 CHEBI
CHEMBL1159717 ChEMBL_ID
DB12248 DRUGBANK_ID
CHEMBL1256478 ChEMBL_ID
5606 PUBCHEM_CID
4564 INN_ID
C010809 MESH_SUPPLEMENTAL_RECORD_UI
591I9SU0F7 UNII
235841 RXNORM
004061 NDDF
004062 NDDF
349929009 SNOMEDCT_US
397178007 SNOMEDCT_US

Pharmaceutical products:

None