azosemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, furosemide derivatives	278	27589-33-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: azosemide diurapid azosemid	Molecular weight: 370.83 Formula: C12H11ClN6O2S2 CLOGP: 1.36 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 126.65 ALOGS: -3.59 ROTB: 5

Molecule

Description

Molfile Inchi Smiles

Synonyms:

azosemide
diurapid
azosemid

Molecular weight: 370.83
Formula: C12H11ClN6O2S2
CLOGP: 1.36
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 126.65
ALOGS: -3.59
ROTB: 5

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	10 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)	1.48 mL/min/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Vd (Volume of distribution)	0.28 L/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

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Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	251.86	26.08	125	4533	89017	63395347
Renal impairment	154.00	26.08	90	4568	88265	63396099
Cardiac failure chronic	120.00	26.08	33	4625	4385	63479979
Anaemia	83.67	26.08	105	4553	293325	63191039
Blood pressure decreased	67.79	26.08	48	4610	64974	63419390
Pulmonary arterial hypertension	67.49	26.08	33	4625	22544	63461820
Cerebral infarction	65.72	26.08	33	4625	23860	63460504
Brain natriuretic peptide increased	63.55	26.08	21	4637	5192	63479172
Cardiac failure acute	61.64	26.08	24	4634	9499	63474865
Right ventricular failure	60.15	26.08	28	4630	17160	63467204

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	250.68	24.73	150	4202	91098	34861481
Renal impairment	151.02	24.73	111	4241	94402	34858177
Cardiac failure chronic	84.12	24.73	33	4319	7846	34944733
Hepatic function abnormal	77.22	24.73	55	4297	44308	34908271
Altered state of consciousness	66.03	24.73	39	4313	22854	34929725
Concomitant disease aggravated	61.27	24.73	24	4328	5677	34946902
Cerebral infarction	59.51	24.73	39	4313	27416	34925163
Blood pressure decreased	55.23	24.73	48	4304	51467	34901112
Pneumonia aspiration	50.98	24.73	42	4310	41861	34910718
Brain natriuretic peptide increased	47.67	24.73	20	4332	5639	34946940

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	436.97	22.97	252	8904	154590	79580642
Renal impairment	281.03	22.97	192	8964	157591	79577641
Cardiac failure chronic	168.54	22.97	59	9097	11076	79724156
Hepatic function abnormal	129.89	22.97	89	9067	73018	79662214
Cerebral infarction	116.87	22.97	70	9086	45606	79689626
Concomitant disease aggravated	112.73	22.97	46	9110	13121	79722111
Brain natriuretic peptide increased	100.50	22.97	38	9118	8862	79726370
Blood pressure decreased	99.36	22.97	86	9070	99380	79635852
Pulmonary arterial hypertension	98.24	22.97	53	9103	28313	79706919
Right ventricular failure	87.27	22.97	46	9110	23451	79711781

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:77608	loop diuretics
MeSH PA	D004232	Diuretics
MeSH PA	D045283	Natriuretic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Congestive heart failure	indication	42343007	DOID:6000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.68	acidic
pKa2	10.12	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
IWE	PDB_CHEM_ID
007033	NDDF
18651	RXNORM
2273	PUBCHEM_CID
3954	INN_ID
C0052820	UMLSCUI
C018222	MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31248	CHEBI
CHEMBL1097235	ChEMBL_ID
D01323	KEGG_DRUG

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Pharmaceutical products:

None