Stem definition | Drug id | CAS RN |
---|---|---|
antibacterials, nalidixic acid derivatives | 2777 | 147059-72-1 |
Dose | Unit | Route |
---|---|---|
0.20 | g | O |
0.20 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
BA (Bioavailability) | 91 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.24 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11 hours | Lombardo F, Berellini G, Obach RS |
S (Water solubility) | 26 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 18, 1997 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | J01MA13 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
MeSH PA | D059003 | Topoisomerase Inhibitors |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:50908 | agente hepatotoxico |
CHEBI has role | CHEBI:53559 | topoisomerase IV inhibitors |
CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Staphylococcal pneumonia | indication | 22754005 | |
Acute gonococcal urethritis | indication | 29864006 | |
Acute bacterial peritonitis | indication | 31860008 | |
Postoperative infection | indication | 33910007 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Gonorrhea of rectum | indication | 42746002 | |
Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
Pneumonia due to Escherichia coli | indication | 51530003 | |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Miscarriage with sepsis | indication | 67465009 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Acute bacterial sinusitis | indication | 75498004 | |
Endomyometritis | indication | 88027004 | |
Female genital tract infection | indication | 125585007 | |
Infectious disease of abdomen | indication | 128070006 | |
Postnatal infection | indication | 178280004 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Chlamydial pelvic inflammatory disease | indication | 188463006 | |
Acute Moraxella catarrhalis bronchitis | indication | 195722003 | |
Acute bacterial bronchitis | indication | 233598009 | |
Chlamydial pneumonia | indication | 233609002 | |
Female pelvic cellulitis | indication | 280486004 | |
Streptococcal Septic Abortion | indication | ||
Complicated Klebsiella Peritonitis | indication | ||
Complicated E. Coli Peritonitis | indication | ||
Enterococcus Endomyometritis | indication | ||
Complicated Streptococcus Peritonitis | indication | ||
Complicated Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
Complicated Bacteroides Peritonitis | indication | ||
Prevotella Postpartum Infection | indication | ||
Gardnerella Endomyometritis | indication | ||
Gardnerella Postpartum Infection | indication | ||
Peptostreptococcus Pelvic Cellulitis | indication | ||
Prevotella Septic Abortion | indication | ||
Bacteroides Septic Abortion | indication | ||
E. Coli Endomyometritis | indication | ||
Colorectal Surgery Infection Prevention | indication | ||
Vaginal Hysterectomy Infection Prevention | indication | ||
Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
Chronic Bacterial Prostatitis | indication | ||
Haemophilus Parainfluenzae Bronchitis | indication | ||
Haemophilus Influenzae Bronchitis | indication | ||
Streptococcus Pneumoniae Bronchitis | indication | ||
Staphylococcus Aureus Bronchitis | indication | ||
Chlamydia Cervicitis | indication | ||
Complicated Skin and Skin Structure Enterococcus Faecalis Infection | indication | ||
Moraxella Catarrhalis Pneumonia | indication | ||
Streptococcal Endomyometritis | indication | ||
Peptostreptococcus Postpartum Infection | indication | ||
Legionella Pneumophila Pneumonia | indication | ||
Peptostreptococcus Septic Abortion | indication | ||
Streptococcal Postpartum Infection | indication | ||
E. Coli Pelvic Cellulitis | indication | ||
E. Coli Postpartum Infection | indication | ||
Enterococcus Postpartum Infection | indication | ||
E. Coli Septic Abortion | indication | ||
Peptostreptococcus Endomyometritis | indication | ||
Gardnerella Septic Abortion | indication | ||
Prevotella Endomyometritis | indication | ||
Complicated Bacterial Peritonitis | indication | ||
Complicated Skin and Skin Structure Staphylococcus Aureus Infection | indication | ||
Prevotella Pelvic Cellulitis | indication | ||
Streptococcal Pelvic Cellulitis | indication | ||
Bacteroides Postpartum Infection | indication | ||
Gardnerella Pelvic Cellulitis | indication | ||
Enterococcus Pelvic Cellulitis | indication | ||
Complicated Skin and Skin Structure Proteus Infection | indication | ||
Enterococcus Septic Abortion | indication | ||
Complicated Skin and Skin Structure E. Coli Infection | indication | ||
Bacteroides Pelvic Cellulitis | indication | ||
Bacteroides Endomyometritis | indication | ||
Complicated Skin and Skin Structure Streptococcus Agalactiae Infection | indication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.92 | acidic |
pKa2 | 8.56 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter | Transporter | Ki | 4.31 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.40 | DRUG MATRIX | |||||
Topoisomerase IV | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
DNA gyrase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4024108 | VUID |
N0000022113 | NUI |
D02123 | KEGG_DRUG |
147059-75-4 | SECONDARY_CAS_RN |
4021091 | VANDF |
4024108 | VANDF |
C0379881 | UMLSCUI |
CHEBI:9763 | CHEBI |
TR6 | PDB_CHEM_ID |
CHEMBL428 | ChEMBL_ID |
DB00685 | DRUGBANK_ID |
C080163 | MESH_SUPPLEMENTAL_RECORD_UI |
62959 | PUBCHEM_CID |
7370 | INN_ID |
9F388J00UK | UNII |
115552 | RXNORM |
5646 | MMSL |
7888 | MMSL |
d04263 | MMSL |
007320 | NDDF |
007321 | NDDF |
116542007 | SNOMEDCT_US |
371322001 | SNOMEDCT_US |
96092008 | SNOMEDCT_US |
CHEMBL1200779 | ChEMBL_ID |
None