tropisetron Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin receptor antagonists (5-HT3) | 2775 | 89565-68-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
| 5 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 11 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 8 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.25 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 66 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 9.70 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 5.60 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1992 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A04AA03 | ALIMENTARY TRACT AND METABOLISM ANTIEMETICS AND ANTINAUSEANTS ANTIEMETICS AND ANTINAUSEANTS Serotonin (5HT3) antagonists |
| CHEBI has role | CHEBI:48279 | serotonergic antagonist |
| CHEBI has role | CHEBI:50919 | antiemetic |
| CHEBI has role | CHEBI:47958 | nicotinic acetylcholine receptor agonist |
| CHEBI has role | CHEBI:36335 | trypanocidal drug |
| CHEBI has role | CHEBI:50846 | immunomodulator |
| CHEBI has role | CHEBI:63726 | neuroprotective agent |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D058831 | Serotonin 5-HT3 Receptor Antagonists |
| MeSH PA | D018490 | Serotonin Agents |
| MeSH PA | D012702 | Serotonin Antagonists |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Chemotherapy-induced nausea and vomiting | indication | 236084000 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.91 | acidic |
| pKa2 | 9.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | Ion channel | ANTAGONIST | Ki | 8.80 | IUPHAR | IUPHAR | |||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 5.61 | DRUG MATRIX | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 8.16 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 4.26 | CHEMBL | |||||
| Acetylcholine receptor; alpha1/beta1/delta/gamma | Ion channel | Ki | 4.57 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-3 | Ion channel | Ki | 4.80 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.28 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 3B | Ion channel | Ki | 8.80 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.85 | WOMBAT-PK | |||||
| Glycine receptor subunit alpha-1 | Ion channel | ANTAGONIST | Ki | 4.10 | IUPHAR | ||||
| Glycine receptor subunit alpha-2 | Ion channel | ANTAGONIST | Ki | 4.90 | IUPHAR | ||||
| Glycine receptor subunit beta | Ion channel | ANTAGONIST | Ki | 5.30 | IUPHAR | ||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 6.59 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 3A | Ion channel | Kd | 7.52 | CHEMBL | |||||
| Serotonin 3 receptor (5HT3) | Ion channel | Ki | 8.42 | CHEMBL | |||||
| Serotonin 3 (5-HT3) receptor | Ion channel | Ki | 8.89 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | EC50 | 8 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 8.16 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 4 | GPCR | Ki | 7.20 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.90 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 4 | Unclassified | ANTAGONIST | Ki | 7.10 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D000077526 | MESH_DESCRIPTOR_UI |
| C0063322 | UMLSCUI |
| D02041 | KEGG_DRUG |
| 6I819NIK1W | UNII |
| 6535 | INN_ID |
| 322201005 | SNOMEDCT_US |
| 27392 | RXNORM |
| 395917006 | SNOMEDCT_US |
| 004472 | NDDF |
| 105826-92-4 | SECONDARY_CAS_RN |
| CHEBI:32269 | CHEBI |
| CHEMBL56564 | ChEMBL_ID |
| TKT | PDB_CHEM_ID |
| DB11699 | DRUGBANK_ID |
| 656665 | PUBCHEM_CID |
| 260 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
None