troleandomycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 2769 | 2751-09-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A macrolide antibiotic that is similar to ERYTHROMYCIN.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.25 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 27, 1969 | FDA | PFIZER |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01FA08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS Macrolides |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:86501 | CYP3A4 inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pneumococcal pneumonia | indication | 233607000 | |
| Upper Respiratory Streptococcal Infection | indication | ||
| Asthma | off-label use | 195967001 | DOID:2841 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.62 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cytochrome P450 3A4 | Enzyme | INHIBITOR | Ki | 7.80 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 4022401 | VUID |
| N0000146829 | NUI |
| D01322 | KEGG_DRUG |
| 4018507 | VANDF |
| 4022401 | VANDF |
| C0041165 | UMLSCUI |
| CHEBI:45735 | CHEBI |
| TAO | PDB_CHEM_ID |
| CHEMBL564085 | ChEMBL_ID |
| D014217 | MESH_DESCRIPTOR_UI |
| DB13179 | DRUGBANK_ID |
| 10209 | IUPHAR_LIGAND_ID |
| 805 | INN_ID |
| C4DZ64560D | UNII |
| 202225 | PUBCHEM_CID |
| 10864 | RXNORM |
| 5643 | MMSL |
| d01076 | MMSL |
| 002765 | NDDF |
| 371016002 | SNOMEDCT_US |
| 64130008 | SNOMEDCT_US |
Pharmaceutical products:
None