Stem definition | Drug id | CAS RN |
---|---|---|
2763 | 486-12-4 |
Dose | Unit | Route |
---|---|---|
7.50 | mg | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 4 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
May 17, 1983 | FDA | SANDOZ |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
COVID-19 | 88.92 | 25.26 | 48 | 2183 | 75010 | 56214826 |
Disease recurrence | 61.25 | 25.26 | 26 | 2205 | 23834 | 56266002 |
Sinusitis | 56.64 | 25.26 | 53 | 2178 | 197528 | 56092308 |
Salpingo-oophorectomy unilateral | 49.04 | 25.26 | 10 | 2221 | 682 | 56289154 |
Sinusitis fungal | 46.15 | 25.26 | 11 | 2220 | 1539 | 56288297 |
Asthma | 45.91 | 25.26 | 37 | 2194 | 112733 | 56177103 |
Sputum increased | 42.71 | 25.26 | 11 | 2220 | 2113 | 56287723 |
Respiratory symptom | 39.74 | 25.26 | 11 | 2220 | 2779 | 56287057 |
Embolism venous | 39.51 | 25.26 | 11 | 2220 | 2837 | 56286999 |
Chronic sinusitis | 38.76 | 25.26 | 14 | 2217 | 8364 | 56281472 |
Nasal polyps | 38.03 | 25.26 | 11 | 2220 | 3254 | 56286582 |
Diastolic dysfunction | 36.04 | 25.26 | 12 | 2219 | 5633 | 56284203 |
Female genital tract fistula | 34.57 | 25.26 | 11 | 2220 | 4481 | 56285355 |
Hysterectomy | 31.12 | 25.26 | 12 | 2219 | 8579 | 56281257 |
Emphysema | 29.38 | 25.26 | 12 | 2219 | 9964 | 56279872 |
Impaired quality of life | 27.74 | 25.26 | 11 | 2220 | 8463 | 56281373 |
Infusion site mass | 26.49 | 25.26 | 7 | 2224 | 1485 | 56288351 |
Eczema | 26.16 | 25.26 | 15 | 2216 | 26138 | 56263698 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
COVID-19 | 60.07 | 34.15 | 25 | 485 | 54796 | 31642038 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
COVID-19 | 113.34 | 27.08 | 58 | 2112 | 105699 | 70820575 |
Disease recurrence | 72.47 | 27.08 | 31 | 2139 | 37572 | 70888702 |
Salpingo-oophorectomy unilateral | 52.32 | 27.08 | 10 | 2160 | 635 | 70925639 |
Asthma | 52.19 | 27.08 | 37 | 2133 | 120756 | 70805518 |
Sinusitis | 51.42 | 27.08 | 42 | 2128 | 169153 | 70757121 |
Sinusitis fungal | 45.74 | 27.08 | 11 | 2159 | 2074 | 70924200 |
Female genital tract fistula | 41.40 | 27.08 | 11 | 2159 | 3092 | 70923182 |
Respiratory symptom | 39.25 | 27.08 | 11 | 2159 | 3770 | 70922504 |
Embolism venous | 39.06 | 27.08 | 11 | 2159 | 3834 | 70922440 |
Sputum increased | 38.44 | 27.08 | 11 | 2159 | 4061 | 70922213 |
Nasal polyps | 37.32 | 27.08 | 11 | 2159 | 4505 | 70921769 |
Hysterectomy | 34.96 | 27.08 | 11 | 2159 | 5601 | 70920673 |
Chronic sinusitis | 34.34 | 27.08 | 12 | 2158 | 8439 | 70917835 |
Diastolic dysfunction | 33.05 | 27.08 | 12 | 2158 | 9421 | 70916853 |
Emphysema | 27.61 | 27.08 | 12 | 2158 | 15048 | 70911226 |
None
Source | Code | Description |
---|---|---|
ATC | R06AX07 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Dermatographic urticaria | indication | 7632005 | DOID:743 |
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Common cold | indication | 82272006 | DOID:10459 |
Urticaria | indication | 126485001 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Itching of skin | indication | 418363000 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Dependent drug abuse | contraindication | 6525002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Asthenia | contraindication | 13791008 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Mood swings | contraindication | 18963009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Acidosis | contraindication | 51387008 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Urethral stricture | contraindication | 76618002 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Acute abdominal pain | contraindication | 116290004 | |
Procedure on urinary system | contraindication | 118677009 | |
Partial atrioventricular block | contraindication | 195039008 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Bladder outflow obstruction | contraindication | 236645006 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Lesion of brain | contraindication | 301766008 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Disorder of coronary artery | contraindication | 414024009 | |
Central nervous system depression | contraindication | 418072004 | |
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Hypertensive urgency | contraindication | 443482000 | |
Acute exacerbation of asthma | contraindication | 708038006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.42 | Basic |
pKa2 | 3.34 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 9.90 | CHEMBL | CHEMBL | |||
Histamine H1 receptor | GPCR | Kd | 9.90 | CHEMBL |
ID | Source |
---|---|
4019964 | VUID |
N0000148049 | NUI |
D08648 | KEGG_DRUG |
6138-79-0 | SECONDARY_CAS_RN |
4018541 | VANDF |
4019964 | VANDF |
C0041098 | UMLSCUI |
CHEBI:84116 | CHEBI |
CHEMBL855 | ChEMBL_ID |
CHEMBL3188034 | ChEMBL_ID |
CHEMBL1200450 | ChEMBL_ID |
DB00427 | DRUGBANK_ID |
D014311 | MESH_DESCRIPTOR_UI |
5282443 | PUBCHEM_CID |
1228 | IUPHAR_LIGAND_ID |
502 | INN_ID |
2L8T9S52QM | UNII |
10849 | RXNORM |
10773 | MMSL |
330097 | MMSL |
5639 | MMSL |
80877 | MMSL |
d00786 | MMSL |
003401 | NDDF |
004799 | NDDF |
25995007 | SNOMEDCT_US |
372678008 | SNOMEDCT_US |
65982003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Wal-Act | HUMAN OTC DRUG LABEL | 2 | 0363-0178 | TABLET, FILM COATED | 2.50 mg | ORAL | OTC monograph final | 16 sections |
Cold and Allergy D | HUMAN OTC DRUG LABEL | 2 | 0363-1780 | TABLET, FILM COATED | 2.50 mg | ORAL | OTC monograph final | 16 sections |
Overnight Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 0363-6980 | SOLUTION | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Overnight Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 0363-6980 | SOLUTION | 2.50 mg | ORAL | OTC monograph final | 17 sections |
ED-A-HIST PSE | HUMAN OTC DRUG LABEL | 2 | 0485-0210 | TABLET, COATED | 2.50 mg | ORAL | OTC monograph final | 16 sections |
TRIPROLIDINE HYDROCHLORIDE | HUMAN OTC DRUG LABEL | 1 | 0536-1257 | LIQUID | 0.94 mg | ORAL | OTC monograph final | 15 sections |
TRIPROLIDINE HYDROCHLORIDE | HUMAN OTC DRUG LABEL | 1 | 0536-1258 | LIQUID | 2.50 mg | ORAL | OTC monograph final | 15 sections |
Aprodine | HUMAN OTC DRUG LABEL | 2 | 0904-0250 | TABLET, FILM COATED | 2.50 mg | ORAL | OTC monograph final | 16 sections |
Aprodine | HUMAN OTC DRUG LABEL | 2 | 0904-7302 | TABLET, FILM COATED | 2.50 mg | ORAL | OTC monograph final | 16 sections |
Target Overnight Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 11673-698 | SOLUTION | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Target Overnight Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 11673-698 | SOLUTION | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Triprolidine HCl Drops | HUMAN OTC DRUG LABEL | 1 | 15310-112 | LIQUID | 0.94 mg | ORAL | OTC monograph final | 13 sections |
Aprodine | HUMAN OTC DRUG LABEL | 2 | 21695-929 | TABLET, FILM COATED | 2.50 mg | ORAL | OTC monograph final | 16 sections |
HISTEX AC | HUMAN OTC DRUG LABEL | 3 | 28595-250 | SYRUP | 2.50 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
HISTEX PD Drops | HUMAN OTC DRUG LABEL | 1 | 28595-801 | SYRUP | 0.94 mg | ORAL | OTC MONOGRAPH FINAL | 14 sections |
HISTEX | HUMAN OTC DRUG LABEL | 1 | 28595-802 | SYRUP | 2.50 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
HISTEX-DM | HUMAN OTC DRUG LABEL | 3 | 28595-804 | SYRUP | 2.50 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Meijer Nighttime Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 41250-869 | SOLUTION | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Aprodine | HUMAN OTC DRUG LABEL | 2 | 50090-0622 | TABLET, FILM COATED | 2.50 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
Silafed | HUMAN OTC DRUG LABEL | 2 | 54838-101 | SYRUP | 1.25 mg | ORAL | OTC MONOGRAPH FINAL | 14 sections |
Triponel | HUMAN OTC DRUG LABEL | 3 | 54859-508 | LIQUID | 1.25 mg | ORAL | OTC monograph final | 9 sections |
Triponel | HUMAN OTC DRUG LABEL | 3 | 54859-514 | LIQUID | 30 mg | ORAL | OTC monograph final | 9 sections |
Triacin-C | HUMAN PRESCRIPTION DRUG LABEL | 3 | 54879-005 | SYRUP | 1.25 mg | ORAL | ANDA | 13 sections |
Colcol Co Tab. | HUMAN OTC DRUG LABEL | 2 | 58354-110 | TABLET | 2.50 mg | ORAL | OTC monograph final | 8 sections |
STAHIST TP | HUMAN OTC DRUG LABEL | 2 | 58407-010 | TABLET | 2.50 mg | ORAL | OTC monograph final | 16 sections |
STAHIST TP | HUMAN OTC DRUG LABEL | 2 | 58407-010 | TABLET | 2.50 mg | ORAL | OTC monograph final | 16 sections |
Maxifed TR | HUMAN OTC DRUG LABEL | 2 | 58605-106 | TABLET | 1.25 mg | ORAL | OTC MONOGRAPH FINAL | 16 sections |
Maxi-Tuss TR | HUMAN OTC DRUG LABEL | 2 | 58605-305 | LIQUID | 1.25 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
Childrens PediaClear PD | HUMAN OTC DRUG LABEL | 1 | 58809-651 | LIQUID | 1.25 mg | ORAL | OTC monograph final | 15 sections |
Childrens PediaClear PD | HUMAN OTC DRUG LABEL | 1 | 58809-651 | LIQUID | 1.25 mg | ORAL | OTC monograph final | 15 sections |