All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

triprolidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2763	486-12-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: actidil triprolidine triprolidin tripyrolidine triprolidine hydrochloride triprolidine HCl	Histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness. Molecular weight: 278.40 Formula: C19H22N2 CLOGP: 3.63 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 16.13 ALOGS: -3.72 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
7.50	mg	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	4 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	100 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 17, 1983	FDA	SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sinusitis	177.30	10.74	459	45643	226194	63216726
Contraindicated product administered	136.03	10.74	5	46097	217643	63225277
Asthma	120.53	10.74	278	45824	127283	63315637
Toxicity to various agents	115.92	10.74	20	46082	247230	63195690
Hand deformity	101.97	10.74	3	46099	159454	63283466
Synovitis	99.82	10.74	10	46092	186908	63256012
Maternal exposure during pregnancy	96.39	10.74	21	46081	220041	63222879
Drug intolerance	93.59	10.74	54	46048	308607	63134313
Glossodynia	87.12	10.74	13	46089	178863	63264057
Systemic lupus erythematosus	85.50	10.74	23	46079	208895	63234025
Treatment failure	85.15	10.74	20	46082	199023	63243897
Off label use	84.39	10.74	233	45869	674229	62768691
Pericarditis	82.26	10.74	3	46099	131576	63311344
Drug ineffective	81.73	10.74	437	45665	1044328	62398592
Drug interaction	77.01	10.74	35	46067	229096	63213824
Anxiety	76.66	10.74	337	45765	217204	63225716
Cough	68.39	10.74	404	45698	292339	63150581
Bronchitis	67.57	10.74	222	45880	124713	63318207
Therapeutic product effect decreased	65.70	10.74	29	46073	193158	63249762
Wound	63.07	10.74	20	46082	163243	63279677
Chest discomfort	62.72	10.74	199	45903	109770	63333150
Infective pulmonary exacerbation of cystic fibrosis	59.19	10.74	50	46052	8767	63434153
Hepatic enzyme increased	59.03	10.74	37	46065	202291	63240629
Infusion related reaction	58.77	10.74	55	46047	245466	63197454
Joint swelling	57.80	10.74	93	46009	327573	63115347
General physical health deterioration	57.16	10.74	38	46064	201364	63241556
Sputum increased	56.44	10.74	30	46072	2429	63440491
Gastrooesophageal reflux disease	55.38	10.74	174	45928	95465	63347455
Diverticulum	55.11	10.74	55	46047	11936	63430984
Dyspnoea	54.95	10.74	726	45376	660587	62782333
Salpingo-oophorectomy unilateral	52.96	10.74	21	46081	860	63442060
Product dose omission issue	51.89	10.74	319	45783	233994	63208926
Deep vein thrombosis	51.81	10.74	156	45946	83644	63359276
Product quality issue	50.20	10.74	92	46010	35773	63407147
Arthropathy	50.09	10.74	58	46044	234734	63208186
Sinusitis fungal	49.69	10.74	25	46077	1806	63441114
Alopecia	49.62	10.74	107	45995	337429	63105491
Rheumatoid factor positive	49.28	10.74	3	46099	84403	63358517
Emotional distress	47.47	10.74	85	46017	32464	63410456
Nasal congestion	47.15	10.74	129	45973	65531	63377389
Helicobacter infection	46.91	10.74	6	46096	92779	63350141
Pulmonary embolism	46.68	10.74	188	45914	116496	63326424
Upper respiratory tract infection	46.33	10.74	148	45954	81899	63361021
Depression	43.16	10.74	267	45835	196225	63246695
Headache	42.90	10.74	671	45431	632570	62810350
Sleep apnoea syndrome	41.11	10.74	75	46027	29058	63413862
Discomfort	40.61	10.74	37	46065	167337	63275583
Diastolic dysfunction	39.99	10.74	35	46067	6436	63436484
Chronic obstructive pulmonary disease	39.98	10.74	118	45984	62568	63380352
Chronic sinusitis	38.36	10.74	47	46055	12796	63430124
Nasal polyps	38.00	10.74	33	46069	6006	63436914
Embolism venous	37.05	10.74	25	46077	3129	63439791
Folliculitis	36.90	10.74	4	46098	70313	63372607
Drug abuse	35.91	10.74	5	46097	72513	63370407
Infusion site erythema	35.30	10.74	43	46059	11636	63431284
C-reactive protein increased	34.15	10.74	13	46089	94694	63348226
Ear infection	33.55	10.74	81	46021	38132	63404788
Respiratory symptom	33.40	10.74	24	46078	3323	63439597
Pneumonia	32.39	10.74	488	45614	456279	62986641
Hiatus hernia	32.27	10.74	57	46045	21537	63421383
Sinus disorder	31.88	10.74	61	46041	24492	63418428
Acute respiratory failure	30.17	10.74	73	46029	34412	63408508
Febrile neutropenia	30.16	10.74	25	46077	118424	63324496
Blister	29.96	10.74	30	46072	129784	63313136
Rheumatoid arthritis	29.89	10.74	90	46012	253729	63189191
Tricuspid valve incompetence	29.19	10.74	44	46058	14577	63428343
Candida infection	28.07	10.74	63	46039	28288	63414632
Emphysema	27.88	10.74	37	46065	10901	63432019
Rhinitis allergic	27.36	10.74	38	46064	11689	63431231
Infusion site pruritus	26.48	10.74	27	46075	6008	63436912
Iron deficiency anaemia	26.41	10.74	50	46052	19919	63423001
Infusion site swelling	26.38	10.74	34	46068	9736	63433184
Chest pain	25.90	10.74	255	45847	215704	63227216
Poor quality device used	25.74	10.74	17	46085	2054	63440866
Hysterectomy	25.56	10.74	33	46069	9466	63433454
Urinary tract infection	25.01	10.74	298	45804	264386	63178534
Cholecystitis chronic	24.81	10.74	34	46068	10327	63432593
Seasonal allergy	24.72	10.74	50	46052	20900	63422020
Dizziness	24.41	10.74	443	45659	429482	63013438
Migraine	24.30	10.74	143	45959	103203	63339717
Product use issue	23.99	10.74	81	46021	220439	63222481
Acute sinusitis	23.97	10.74	21	46081	3866	63439054
Intentional overdose	23.85	10.74	12	46090	74140	63368780
Swelling	23.71	10.74	111	45991	275267	63167653
Neutropenia	23.64	10.74	58	46044	174947	63267973
C-reactive protein abnormal	23.25	10.74	3	46099	46093	63396827
Coma	22.93	10.74	9	46093	64355	63378565
Product use in unapproved indication	22.92	10.74	61	46041	179019	63263901
Wheezing	22.29	10.74	132	45970	95463	63347457
Hypervolaemia	21.57	10.74	57	46045	28356	63414564
Female genital tract fistula	21.51	10.74	27	46075	7532	63435388
Malignant neoplasm progression	21.32	10.74	17	46085	82104	63360816
Disease recurrence	21.04	10.74	56	46046	27974	63414946
Injury	21.01	10.74	107	45995	73140	63369780
Pulmonary hypertension	20.98	10.74	67	46035	37056	63405864
Liver injury	20.69	10.74	9	46093	60511	63382409
Coronary artery disease	20.69	10.74	61	46041	32316	63410604
Infusion site nodule	20.39	10.74	13	46089	1479	63441441
Oedema peripheral	19.98	10.74	218	45884	189293	63253627
Musculoskeletal stiffness	19.95	10.74	68	46034	184550	63258370
Gastroenteritis viral	19.49	10.74	49	46053	23651	63419269
Hyponatraemia	19.46	10.74	32	46070	111868	63331052
Lower respiratory tract infection	19.35	10.74	42	46060	132265	63310655
Abdominal discomfort	19.31	10.74	145	45957	320740	63122180
Anhedonia	19.09	10.74	31	46071	10943	63431977
Muscle spasms	19.01	10.74	185	45917	155965	63286955
Thrombocytopenia	18.95	10.74	52	46050	151105	63291815
Infusion site extravasation	18.88	10.74	30	46072	10396	63432524
Infusion site mass	18.76	10.74	14	46088	2054	63440866
Anosmia	18.72	10.74	24	46078	6836	63436084
Dyspnoea exertional	18.65	10.74	90	46012	60212	63382708
Palpitations	18.65	10.74	143	45959	112627	63330293
Hereditary angioedema	18.39	10.74	25	46077	7537	63435383
Red blood cell sedimentation rate increased	17.67	10.74	5	46097	43977	63398943
Feeling abnormal	17.67	10.74	175	45927	148217	63294703
Insurance issue	17.63	10.74	22	46080	6099	63436821
Multiple allergies	17.56	10.74	34	46068	13768	63429152
Biliary dyskinesia	17.35	10.74	15	46087	2714	63440206
Low turnover osteopathy	17.06	10.74	18	46084	4167	63438753
Neck pain	16.99	10.74	97	46005	69221	63373699
Back pain	16.69	10.74	277	45825	263868	63179052
Gallbladder disorder	16.60	10.74	40	46062	18802	63424118
Pancytopenia	16.60	10.74	28	46074	96905	63346015
Cardiac failure congestive	16.29	10.74	119	45983	92314	63350606
Panic attack	16.15	10.74	44	46058	22287	63420633
Mucosal inflammation	16.01	10.74	7	46095	46921	63395999
Sinus headache	15.88	10.74	20	46082	5596	63437324
Mobility decreased	15.70	10.74	41	46061	121118	63321802
Multiple organ dysfunction syndrome	15.69	10.74	11	46091	56741	63386179
Flatulence	15.56	10.74	58	46044	34644	63408276
Leukopenia	15.50	10.74	20	46082	77270	63365650
Viral infection	15.49	10.74	59	46043	35604	63407316
Impaired healing	15.46	10.74	32	46070	102510	63340410
Drug-induced liver injury	15.39	10.74	5	46097	40217	63402703
Liver disorder	15.39	10.74	10	46092	53677	63389243
Fungal infection	15.20	10.74	60	46042	36814	63406106
Depressed level of consciousness	14.72	10.74	14	46088	62064	63380856
Anaphylactic reaction	14.60	10.74	90	46012	66010	63376910
Pulmonary function test decreased	14.38	10.74	16	46086	3931	63438989
Uterine perforation	13.96	10.74	21	46081	6942	63435978
Vitamin D deficiency	13.90	10.74	31	46071	13861	63429059
Rhinorrhoea	13.68	10.74	88	46014	65489	63377431
Transient ischaemic attack	13.65	10.74	59	46043	37694	63405226
Device dislocation	13.27	10.74	45	46057	25660	63417260
Infusion site bruising	13.05	10.74	15	46087	3817	63439103
Premature delivery	13.02	10.74	3	46099	30278	63412642
Impaired quality of life	12.95	10.74	30	46072	13753	63429167
Spinal osteoarthritis	12.83	10.74	33	46069	16153	63426767
Essential hypertension	12.79	10.74	17	46085	5016	63437904
Confusional state	12.74	10.74	110	45992	236270	63206650
Overdose	12.69	10.74	42	46060	115036	63327884
Dermatitis contact	12.66	10.74	26	46076	10982	63431938
Hyperlipidaemia	12.62	10.74	37	46065	19534	63423386
Insomnia	12.60	10.74	223	45879	215029	63227891
Cardio-respiratory arrest	12.56	10.74	15	46087	59944	63382976
Hypoxia	12.33	10.74	80	46022	59712	63383208
Foetal exposure during pregnancy	12.18	10.74	4	46098	31958	63410962
Myalgia	12.12	10.74	161	45941	146368	63296552
Urticaria	12.03	10.74	178	45924	165624	63277296
Infusion site pain	11.96	10.74	33	46069	16836	63426084
Ageusia	11.94	10.74	29	46073	13699	63429221
Dysphonia	11.91	10.74	67	46035	47547	63395373
Ill-defined disorder	11.91	10.74	26	46076	81729	63361191
Acute kidney injury	11.90	10.74	128	45974	263287	63179633
Atrophic vulvovaginitis	11.81	10.74	10	46092	1758	63441162
Gallbladder injury	11.51	10.74	9	46093	1414	63441506
Diverticulitis	11.49	10.74	58	46044	39499	63403421
Memory impairment	11.47	10.74	121	45981	104137	63338783
Cellulitis	11.43	10.74	100	46002	81858	63361062
Urine analysis abnormal	11.32	10.74	16	46086	5000	63437920
Exercise test abnormal	11.20	10.74	4	46098	122	63442798
Rash	11.18	10.74	316	45786	560555	62882365
Infusion site haemorrhage	11.15	10.74	16	46086	5070	63437850
Hepatic failure	11.12	10.74	6	46096	35650	63407270
Hip arthroplasty	11.00	10.74	11	46091	47635	63395285
Therapeutic product effect incomplete	10.99	10.74	50	46052	125006	63317914
Hyperkalaemia	10.90	10.74	14	46088	54189	63388731
Metabolic acidosis	10.88	10.74	10	46092	45059	63397861

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sinusitis	111.13	12.51	123	18425	41279	34897104
Asthma	66.95	12.51	97	18451	42559	34895824
Toxicity to various agents	66.23	12.51	13	18535	200349	34738034
Infective pulmonary exacerbation of cystic fibrosis	57.47	12.51	39	18509	6762	34931621
Drug interaction	52.87	12.51	27	18521	225919	34712464
Upper respiratory tract infection	51.60	12.51	75	18473	32984	34905399
Fatigue	35.88	12.51	326	18222	370327	34568056
Drug abuse	35.88	12.51	5	18543	99091	34839292
Cough	35.00	12.51	165	18383	149975	34788408
Dyspnoea	28.96	12.51	316	18232	376466	34561917
Product dose omission issue	28.20	12.51	132	18416	119579	34818804
Off label use	27.51	12.51	122	18426	419402	34518981
Nasal congestion	27.19	12.51	46	18502	23011	34915372
Pneumonia	24.64	12.51	297	18251	362330	34576053
Bronchitis	23.80	12.51	62	18486	41901	34896482
Cystic fibrosis	22.89	12.51	13	18535	1645	34936738
Headache	21.14	12.51	180	18368	200455	34737928
Anxiety	20.80	12.51	106	18442	99322	34839061
Ear infection	20.17	12.51	26	18522	10205	34928178
Productive cough	19.56	12.51	54	18494	37759	34900624
Chest pain	19.20	12.51	124	18424	126638	34811745
General physical health deterioration	19.10	12.51	24	18524	128245	34810138
Febrile neutropenia	18.96	12.51	27	18521	136822	34801561
Sinus disorder	18.89	12.51	21	18527	7064	34931319
Personality change	18.70	12.51	18	18530	5121	34933262
Infusion site pruritus	18.67	12.51	9	18539	814	34937569
Product complaint	18.43	12.51	19	18529	5871	34932512
Rhinorrhoea	17.83	12.51	41	18507	25627	34912756
Back pain	17.75	12.51	118	18430	121671	34816712
Sputum discoloured	17.23	12.51	21	18527	7791	34930592
Myalgia	17.12	12.51	89	18459	84021	34854362
Gastroenteritis viral	17.11	12.51	20	18528	7104	34931279
Infusion site erythema	16.78	12.51	12	18536	2261	34936122
Acute kidney injury	16.35	12.51	95	18453	304893	34633490
Drug ineffective	16.10	12.51	160	18388	456591	34481792
Rhinitis allergic	15.71	12.51	13	18535	3037	34935346
Vision blurred	14.97	12.51	56	18492	45907	34892476
Wheezing	14.80	12.51	52	18496	41350	34897033
Cystic fibrosis related diabetes	14.73	12.51	5	18543	181	34938202
Sleep apnoea syndrome	14.71	12.51	33	18515	20288	34918095
Thrombocytopenia	14.55	12.51	39	18509	156208	34782175
Hepatic function abnormal	14.37	12.51	3	18545	44360	34894023
Intentional overdose	14.05	12.51	3	18545	43671	34894712
Neutropenia	13.95	12.51	40	18508	156738	34781645
Pulmonary function test decreased	13.71	12.51	15	18533	4960	34933423
Dyspnoea paroxysmal nocturnal	13.63	12.51	9	18539	1490	34936893
Overdose	13.59	12.51	17	18531	91042	34847341
Blood testosterone decreased	13.53	12.51	14	18534	4343	34934040
Seasonal allergy	13.21	12.51	17	18531	6658	34931725
Hypoxia	13.13	12.51	61	18487	55034	34883349
Dizziness	13.08	12.51	175	18373	218346	34720037
Pancreatic failure	13.06	12.51	7	18541	791	34937592
Completed suicide	12.97	12.51	20	18528	98148	34840235
Nasopharyngitis	12.85	12.51	72	18476	69896	34868487
Malignant neoplasm progression	12.56	12.51	17	18531	88029	34850354

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	181.66	10.66	22	48629	421518	79274219
Drug interaction	132.73	10.66	44	48607	415139	79280598
Asthma	122.60	10.66	261	48390	134834	79560903
Sinusitis	121.50	10.66	326	48325	195175	79500562
Infective pulmonary exacerbation of cystic fibrosis	113.71	10.66	80	48571	12771	79682966
Completed suicide	102.93	10.66	14	48637	245753	79449984
Off label use	102.57	10.66	254	48397	906961	78788776
Contraindicated product administered	79.48	10.66	4	48647	157534	79538203
Drug abuse	79.41	10.66	5	48646	162686	79533051
Anxiety	79.39	10.66	331	48320	248181	79447556
Cough	79.06	10.66	436	48215	366353	79329384
Dyspnoea	73.23	10.66	821	47830	856204	78839533
Gastrooesophageal reflux disease	69.96	10.66	179	48472	104067	79591670
Drug ineffective	67.50	10.66	386	48265	1080527	78615210
Deep vein thrombosis	66.53	10.66	193	48458	120726	79575011
Upper respiratory tract infection	65.85	10.66	161	48490	91007	79604730
Sputum increased	63.74	10.66	38	48613	4575	79691162
Product dose omission issue	63.50	10.66	309	48342	247228	79448509
Chest discomfort	62.63	10.66	206	48445	137838	79557899
Synovitis	59.84	10.66	10	48641	150724	79545013
Nasal congestion	58.30	10.66	138	48513	76414	79619323
Salpingo-oophorectomy unilateral	57.64	10.66	21	48630	813	79694924
C-reactive protein increased	57.33	10.66	6	48645	129021	79566716
Treatment failure	54.51	10.66	18	48633	170468	79525269
Product quality issue	54.38	10.66	84	48567	33856	79661881
General physical health deterioration	53.94	10.66	53	48598	275185	79420552
Emotional distress	51.96	10.66	90	48561	39879	79655858
Hand deformity	51.29	10.66	3	48648	103916	79591821
Pulmonary embolism	49.67	10.66	222	48429	171432	79524305
Pericarditis	48.57	10.66	4	48647	104232	79591505
Maternal exposure during pregnancy	48.10	10.66	12	48639	136526	79559211
Sinusitis fungal	47.67	10.66	25	48626	2349	79693388
Bronchitis	47.26	10.66	181	48470	130463	79565274
Drug intolerance	46.06	10.66	56	48595	264063	79431674
Depression	44.82	10.66	255	48396	216535	79479202
Sleep apnoea syndrome	44.65	10.66	80	48571	36398	79659339
Headache	44.27	10.66	600	48051	653172	79042565
Hiatus hernia	43.53	10.66	62	48589	23250	79672487
Febrile neutropenia	43.52	10.66	46	48605	230953	79464784
Chest pain	42.87	10.66	307	48344	281997	79413740
Diastolic dysfunction	40.52	10.66	41	48610	10770	79684967
Pneumonia	40.30	10.66	595	48056	659651	79036086
Infusion related reaction	38.90	10.66	50	48601	230187	79465550
Neutropenia	38.59	10.66	73	48578	287637	79408100
Nasal polyps	37.45	10.66	33	48618	7294	79688443
Thrombocytopenia	36.73	10.66	66	48585	265193	79430544
Intentional overdose	36.01	10.66	10	48641	105950	79589787
Systemic lupus erythematosus	35.03	10.66	15	48636	121134	79574603
Acute kidney injury	34.71	10.66	181	48470	519223	79176514
Diverticulum	34.50	10.66	44	48607	14852	79680885
Chronic sinusitis	34.23	10.66	41	48610	12985	79682752
Rhinitis allergic	32.87	10.66	39	48612	12230	79683507
Chronic obstructive pulmonary disease	32.25	10.66	120	48531	85299	79610438
Embolism venous	32.06	10.66	24	48627	4215	79691522
Dizziness	31.91	10.66	474	48177	525967	79169770
Wheezing	31.58	10.66	148	48503	116516	79579221
Hysterectomy	31.56	10.66	28	48623	6244	79689493
Female genital tract fistula	30.72	10.66	27	48624	5948	79689789
Product use in unapproved indication	30.61	10.66	67	48584	250292	79445445
Infusion site pruritus	30.45	10.66	23	48628	4095	79691642
Infusion site erythema	30.32	10.66	33	48618	9427	79686310
Acute respiratory failure	29.85	10.66	92	48559	59449	79636288
Coma	29.84	10.66	12	48639	100637	79595100
Sinus disorder	29.74	10.66	51	48600	22413	79673324
Injury	29.36	10.66	109	48542	77387	79618350
Joint swelling	29.27	10.66	85	48566	288561	79407176
Helicobacter infection	29.09	10.66	4	48647	69700	79626037
Urinary tract infection	28.98	10.66	275	48376	274237	79421500
Acute sinusitis	28.33	10.66	23	48628	4547	79691190
Hypervolaemia	28.31	10.66	73	48578	42617	79653120
Respiratory symptom	27.37	10.66	23	48628	4768	79690969
Fatigue	27.06	10.66	750	47901	928977	78766760
Pulmonary hypertension	26.67	10.66	77	48574	48003	79647734
Glossodynia	26.53	10.66	15	48636	103322	79592415
Rheumatoid factor positive	26.02	10.66	3	48648	59836	79635901
Pancytopenia	25.97	10.66	38	48613	165707	79530030
Hypoxia	25.80	10.66	128	48523	103115	79592622
Cholecystitis chronic	25.74	10.66	31	48620	9875	79685862
Malignant neoplasm progression	25.69	10.66	27	48624	135963	79559774
Therapeutic product effect decreased	25.25	10.66	38	48613	163825	79531912
Migraine	25.16	10.66	113	48538	87380	79608357
Cystic fibrosis	25.05	10.66	20	48631	3860	79691877
Iron deficiency anaemia	24.89	10.66	51	48600	25621	79670116
Gastroenteritis viral	24.87	10.66	50	48601	24781	79670956
Dyspnoea exertional	24.70	10.66	112	48539	86961	79608776
Poor quality device used	24.44	10.66	16	48635	2269	79693468
Candida infection	23.96	10.66	64	48587	38150	79657587
Coronary artery disease	23.90	10.66	91	48560	65383	79630354
Myalgia	23.20	10.66	193	48458	185448	79510289
Gamma-glutamyltransferase increased	23.14	10.66	3	48648	54677	79641060
Product complaint	22.74	10.66	34	48617	13315	79682422
Oedema peripheral	22.43	10.66	244	48407	252044	79443693
Sinus headache	22.28	10.66	21	48630	5059	79690678
Cardiac failure congestive	22.24	10.66	156	48495	142246	79553491
Depressed level of consciousness	22.12	10.66	16	48635	96636	79599101
Hyperlipidaemia	22.02	10.66	49	48602	26044	79669693
Overdose	21.93	10.66	50	48601	184156	79511581
Ear infection	21.93	10.66	58	48593	34374	79661363
Palpitations	21.75	10.66	142	48509	126468	79569269
Back pain	21.67	10.66	282	48369	303898	79391839
Interstitial lung disease	21.67	10.66	22	48629	112578	79583159
Emphysema	21.57	10.66	37	48614	16263	79679474
Tricuspid valve incompetence	21.32	10.66	41	48610	19671	79676066
Hepatotoxicity	21.30	10.66	3	48648	51349	79644388
Folliculitis	21.26	10.66	4	48647	55376	79640361
Hepatic function abnormal	21.21	10.66	9	48642	73098	79622639
Disease recurrence	21.04	10.66	67	48584	44042	79651695
Muscle spasms	20.95	10.66	180	48471	174550	79521187
Wound	20.91	10.66	24	48627	116155	79579582
Biliary dyskinesia	20.58	10.66	15	48636	2530	79693207
Multiple organ dysfunction syndrome	20.41	10.66	26	48625	120220	79575517
Cerebrovascular accident	20.23	10.66	163	48488	155129	79540608
Device dislocation	19.96	10.66	47	48604	25923	79669814
Drug-induced liver injury	19.41	10.66	8	48643	66109	79629628
Hyperkalaemia	19.15	10.66	25	48626	114373	79581364
Infusion site mass	19.13	10.66	12	48639	1581	79694156
Blister	19.10	10.66	27	48624	119449	79576288
Feeling abnormal	19.09	10.66	164	48487	159035	79536702
Seasonal allergy	18.83	10.66	35	48616	16371	79679366
Renal impairment	18.64	10.66	43	48608	157740	79537997
Metabolic acidosis	18.44	10.66	14	48637	82515	79613222
Intentional product use issue	18.34	10.66	41	48610	152071	79543666
Rhinorrhoea	18.07	10.66	93	48558	75981	79619756
Mucosal inflammation	17.97	10.66	12	48639	75568	79620169
Infusion site swelling	17.94	10.66	23	48628	7803	79687934
Neck pain	17.78	10.66	92	48559	75325	79620412
Bradycardia	17.63	10.66	35	48616	135522	79560215
Hepatic enzyme increased	17.62	10.66	55	48596	182555	79513182
Sleep disorder due to general medical condition, insomnia type	17.04	10.66	3	48648	43553	79652184
Leukopenia	17.02	10.66	28	48623	116485	79579252
Spinal osteoarthritis	16.85	10.66	34	48617	16893	79678844
Uterine perforation	16.83	10.66	20	48631	6283	79689454
Rheumatoid arthritis	16.64	10.66	68	48583	208402	79487335
Liver disorder	16.55	10.66	12	48639	72405	79623332
Drug resistance	16.31	10.66	3	48648	42210	79653527
Rhabdomyolysis	15.80	10.66	24	48627	103107	79592630
Septic shock	15.72	10.66	32	48619	122769	79572968
Insomnia	15.69	10.66	223	48428	244947	79450790
Toxic epidermal necrolysis	15.54	10.66	4	48647	44577	79651160
Mood swings	15.30	10.66	36	48615	19844	79675893
Pulmonary fibrosis	15.29	10.66	4	48647	44108	79651629
Pulmonary function test decreased	15.28	10.66	21	48630	7616	79688121
Nervousness	15.25	10.66	50	48601	33365	79662372
Altered state of consciousness	15.14	10.66	4	48647	43818	79651919
Pain in extremity	15.10	10.66	309	48342	364229	79331508
Cardio-respiratory arrest	15.00	10.66	27	48624	108483	79587254
Anhedonia	14.92	10.66	30	48621	14868	79680869
Gallbladder disorder	14.86	10.66	35	48616	19305	79676432
Blood lactate dehydrogenase increased	14.68	10.66	3	48648	39167	79656570
Panic attack	14.62	10.66	40	48611	24176	79671561
Productive cough	14.52	10.66	98	48553	88233	79607504
Cellulitis	14.49	10.66	115	48536	108945	79586792
Hepatitis	14.43	10.66	8	48643	55719	79640018
Right ventricular failure	14.37	10.66	39	48612	23458	79672279
Essential hypertension	14.21	10.66	18	48633	6035	79689702
Cholestasis	14.20	10.66	7	48644	52102	79643635
Eosinophilia	14.12	10.66	5	48646	45340	79650397
Ear canal erythema	14.01	10.66	3	48648	14	79695723
Nasal discomfort	13.98	10.66	17	48634	5466	79690271
Delirium	13.65	10.66	19	48632	84608	79611129
Therapy cessation	13.53	10.66	52	48599	37510	79658227
Viral infection	13.46	10.66	57	48594	42959	79652778
Eye pruritus	13.45	10.66	35	48616	20535	79675202
Liver injury	13.44	10.66	9	48642	56605	79639132
Insurance issue	13.38	10.66	17	48634	5716	79690021
Arthropathy	13.38	10.66	59	48592	177052	79518685
Dyspnoea paroxysmal nocturnal	13.36	10.66	11	48640	2217	79693520
Sputum discoloured	13.21	10.66	36	48615	21707	79674030
Vision blurred	13.17	10.66	110	48541	105788	79589949
Cystic fibrosis related diabetes	13.09	10.66	5	48646	221	79695516
Alopecia	13.07	10.66	85	48566	231270	79464467
Status asthmaticus	12.95	10.66	8	48643	1026	79694711
Hepatic failure	12.91	10.66	11	48640	61201	79634536
Pain in jaw	12.81	10.66	59	48592	46092	79649645
Red blood cell sedimentation rate increased	12.79	10.66	6	48645	45936	79649801
Pulmonary arterial hypertension	12.55	10.66	42	48609	28324	79667413
Carpal tunnel syndrome	12.54	10.66	33	48618	19495	79676242
Tubulointerstitial nephritis	12.28	10.66	4	48647	38231	79657506
Musculoskeletal stiffness	12.21	10.66	60	48591	174948	79520789
Sinus operation	12.17	10.66	11	48640	2514	79693223
Lactic acidosis	12.16	10.66	15	48636	70344	79625393
Suicidal ideation	12.13	10.66	84	48567	76256	79619481
Complex regional pain syndrome	12.05	10.66	10	48641	2038	79693699
Cardiac arrest	12.01	10.66	59	48592	172037	79523700
Discomfort	12.00	10.66	38	48613	125579	79570158
Eczema	11.94	10.66	53	48598	40765	79654972
Hyponatraemia	11.83	10.66	62	48589	177786	79517951
Stomatitis	11.63	10.66	48	48603	146709	79549028
Transient ischaemic attack	11.54	10.66	63	48588	52632	79643105
Atrophic vulvovaginitis	11.50	10.66	8	48643	1253	79694484
Transplant evaluation	11.50	10.66	9	48642	1688	79694049
Therapeutic product effect incomplete	11.43	10.66	46	48605	141599	79554138
Device breakage	11.30	10.66	22	48629	10653	79685084
Urticaria	11.27	10.66	167	48484	185034	79510703
Cytomegalovirus infection	11.22	10.66	6	48645	42638	79653099
Hereditary angioedema	11.18	10.66	15	48636	5320	79690417
Staphylococcal infection	11.01	10.66	67	48584	58228	79637509
Optic disc drusen	10.98	10.66	3	48648	44	79695693
Right ventricular systolic pressure increased	10.94	10.66	7	48644	955	79694782

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R06AX07	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents
CHEBI has role	CHEBI:37955	H1 receptor antagonists

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dermatographic urticaria	indication	7632005	DOID:743
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Common cold	indication	82272006	DOID:10459
Urticaria	indication	126485001
Seasonal allergic rhinitis	indication	367498001
Itching of skin	indication	418363000
Allergic conjunctivitis	indication	473460002	DOID:11204
Ocular hypertension	contraindication	4210003	DOID:9282
Dependent drug abuse	contraindication	6525002
Peptic ulcer	contraindication	13200003	DOID:750
Asthenia	contraindication	13791008
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Myocardial infarction	contraindication	22298006	DOID:5844
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Hypothyroidism	contraindication	40930008	DOID:1459
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Acidosis	contraindication	51387008
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Urethral stricture	contraindication	76618002
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Epilepsy	contraindication	84757009	DOID:1826
Kidney disease	contraindication	90708001	DOID:557
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Disease of liver	contraindication	235856003	DOID:409
Bladder outflow obstruction	contraindication	236645006
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Lesion of brain	contraindication	301766008
Primary adrenocortical insufficiency	contraindication	373662000
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Pseudomembranous enterocolitis	contraindication	397683000
Disorder of coronary artery	contraindication	414024009
Central nervous system depression	contraindication	418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Acute exacerbation of asthma	contraindication	708038006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.42	Basic
pKa2	3.34	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	9.90		CHEMBL	CHEMBL
Histamine H1 receptor	GPCR		HRH1_CAVPO		Kd	9.90		CHEMBL

External reference:

ID	Source
4019964	VUID
N0000148049	NUI
D08648	KEGG_DRUG
6138-79-0	SECONDARY_CAS_RN
4018541	VANDF
4019964	VANDF
C0041098	UMLSCUI
CHEBI:84116	CHEBI
CHEMBL855	ChEMBL_ID
CHEMBL3188034	ChEMBL_ID
CHEMBL1200450	ChEMBL_ID
DB00427	DRUGBANK_ID
D014311	MESH_DESCRIPTOR_UI
5282443	PUBCHEM_CID
1228	IUPHAR_LIGAND_ID
502	INN_ID
2L8T9S52QM	UNII
10849	RXNORM
10773	MMSL
330097	MMSL
5639	MMSL
80877	MMSL
d00786	MMSL
003401	NDDF
004799	NDDF
25995007	SNOMEDCT_US
372678008	SNOMEDCT_US
65982003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
FLONASENighttime Allergy Relief	HUMAN OTC DRUG LABEL	1	0135-1329	TABLET	2.50 mg	ORAL	OTC monograph final	15 sections
Wal-Act	HUMAN OTC DRUG LABEL	2	0363-0178	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Wal-Act	HUMAN OTC DRUG LABEL	2	0363-0178	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Cold and Allergy D	HUMAN OTC DRUG LABEL	2	0363-0287	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Cold and Allergy D	HUMAN OTC DRUG LABEL	2	0363-1780	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Cold and Allergy D	HUMAN OTC DRUG LABEL	2	0363-1780	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Overnight Cold and Flu	HUMAN OTC DRUG LABEL	3	0363-6980	SOLUTION	2.50 mg	ORAL	OTC monograph final	17 sections
Overnight Cold and Flu	HUMAN OTC DRUG LABEL	3	0363-6980	SOLUTION	2.50 mg	ORAL	OTC monograph final	17 sections
ED-A-HIST PSE	HUMAN OTC DRUG LABEL	2	0485-0210	TABLET, COATED	2.50 mg	ORAL	OTC monograph final	16 sections
TRIPROLIDINE HYDROCHLORIDE	HUMAN OTC DRUG LABEL	1	0536-1257	LIQUID	0.94 mg	ORAL	OTC monograph final	15 sections
TRIPROLIDINE HYDROCHLORIDE	HUMAN OTC DRUG LABEL	1	0536-1258	LIQUID	2.50 mg	ORAL	OTC monograph final	15 sections
Aprodine	HUMAN OTC DRUG LABEL	2	0904-0250	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Aprodine	HUMAN OTC DRUG LABEL	2	0904-0250	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Aprodine	HUMAN OTC DRUG LABEL	2	0904-7302	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Aprodine	HUMAN OTC DRUG LABEL	2	0904-7302	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
Target Overnight Cold and Flu	HUMAN OTC DRUG LABEL	3	11673-698	SOLUTION	2.50 mg	ORAL	OTC monograph final	17 sections
Target Overnight Cold and Flu	HUMAN OTC DRUG LABEL	3	11673-698	SOLUTION	2.50 mg	ORAL	OTC monograph final	17 sections
Triprolidine HCl Drops	HUMAN OTC DRUG LABEL	1	15310-112	LIQUID	0.94 mg	ORAL	OTC monograph final	13 sections
Aprodine	HUMAN OTC DRUG LABEL	2	21695-929	TABLET, FILM COATED	2.50 mg	ORAL	OTC monograph final	16 sections
HISTEX AC	HUMAN OTC DRUG LABEL	3	28595-250	SYRUP	2.50 mg	ORAL	OTC MONOGRAPH FINAL	17 sections
HISTEX PD Drops	HUMAN OTC DRUG LABEL	1	28595-801	SYRUP	0.94 mg	ORAL	OTC MONOGRAPH FINAL	14 sections
HISTEX PD Drops	HUMAN OTC DRUG LABEL	1	28595-801	SYRUP	0.94 mg	ORAL	OTC MONOGRAPH FINAL	14 sections
HISTEX	HUMAN OTC DRUG LABEL	1	28595-802	SYRUP	2.50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
HISTEX	HUMAN OTC DRUG LABEL	1	28595-802	SYRUP	2.50 mg	ORAL	OTC MONOGRAPH FINAL	15 sections
HISTEX-DM	HUMAN OTC DRUG LABEL	3	28595-804	SYRUP	2.50 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
HISTEX-DM	HUMAN OTC DRUG LABEL	3	28595-804	SYRUP	2.50 mg	ORAL	OTC MONOGRAPH FINAL	16 sections
HISTEX PDX Drops	HUMAN OTC DRUG LABEL	1	28595-808	SYRUP	1.25 mg	ORAL	OTC monograph final	17 sections
Meijer Nighttime Cold and Flu	HUMAN OTC DRUG LABEL	3	41250-869	SOLUTION	2.50 mg	ORAL	OTC monograph final	17 sections
Aprodine	HUMAN OTC DRUG LABEL	2	50090-0622	TABLET, FILM COATED	2.50 mg	ORAL	OTC MONOGRAPH FINAL	17 sections
Aprodine	HUMAN OTC DRUG LABEL	2	50090-0622	TABLET, FILM COATED	2.50 mg	ORAL	OTC MONOGRAPH FINAL	17 sections