tripelennamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2762 91-81-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tripelennamine
  • pyribenzamin
  • pyribenzamine
  • pyrinamine base
  • tripelenamine
  • tripelennamin
  • tripelennamine citrate
  • tripelennamine hydrochloride
  • tripelennamine HCl
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
  • Molecular weight: 255.37
  • Formula: C16H21N3
  • CLOGP: 3.31
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 19.37
  • ALOGS: -1.95
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 19, 1948 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D04AA04 DERMATOLOGICALS
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Antihistamines for topical use
ATC R06AC04 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Substituted ethylene diamines
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Urticaria indication 126485001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Anaphylaxis Adjunct indication
Ocular hypertension contraindication 4210003 DOID:9282
Peptic ulcer contraindication 13200003 DOID:750
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic idiopathic constipation contraindication 82934008
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Antihistaminic therapy Indication
Cattle Antihistaminic therapy Indication
Dogs Antihistaminic therapy Indication
Horses Antihistaminic therapy Indication

🐶 Veterinary products

ProductApplicantIngredients
RE-COVR Kinetic Technologies LLC 1
Tripelennamine Hydrochloride Injection Huvepharma EOOD 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.62 Basic
pKa2 4.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST IC50 7.40 CHEMBL CHEMBL

External reference:

IDSource
4019963 VUID
N0000148048 NUI
D02091 KEGG_DRUG
6138-56-3 SECONDARY_CAS_RN
154-69-8 SECONDARY_CAS_RN
4018394 VANDF
4018395 VANDF
4019963 VANDF
C0041090 UMLSCUI
CHEBI:9741 CHEBI
CHEMBL1241 ChEMBL_ID
CHEMBL151676 ChEMBL_ID
DB00792 DRUGBANK_ID
D014309 MESH_DESCRIPTOR_UI
5587 PUBCHEM_CID
7318 IUPHAR_LIGAND_ID
1548 INN_ID
3C5ORO99TY UNII
10847 RXNORM
3076 MMSL
5638 MMSL
d00781 MMSL
003374 NDDF
003375 NDDF
003376 NDDF
25014009 SNOMEDCT_US
373475006 SNOMEDCT_US
53405009 SNOMEDCT_US
CHEMBL1200769 ChEMBL_ID
CHEMBL1200446 ChEMBL_ID

Pharmaceutical products:

None