All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

trimetazidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	2750	5011-34-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: kyurinett trimetazidine vastarel trimetazidine hydrochloride trimetazidine dihydrochloride trimetazidine HCl	A vasodilator used in angina of effort or ischemic heart disease. Molecular weight: 266.34 Formula: C14H22N2O3 CLOGP: 1.27 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 42.96 ALOGS: -2.55 ROTB: 5

Drug dosage:

Dose	Unit	Route
40	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	62 %	Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)	89 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	54
kinase-selectivity-class	AKT3,ALK,AXL,BRAF,CAMK2D,CDK9,DDR1,EPHB4,ERBB2,FLT3,IRAK3,JAK1,MAP3K21,MAP4K1,MAPK7,PDK4,PIK3CB,PRKDC,SIK2,SIK3,TTK,ULK1	22
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1978	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Tachypnoea	90.19	28.59	31	2683	21278	90604455
Cardiac failure	79.11	28.59	46	2668	109450	90516283
Ventricular hypokinesia	53.32	28.59	15	2699	5326	90620407
Cardiac failure chronic	52.49	28.59	15	2699	5631	90620102
Lipohypertrophy	51.17	28.59	10	2704	729	90625004
Orthopnoea	49.66	28.59	15	2699	6820	90618913
Perseveration	46.77	28.59	8	2706	277	90625456
Apraxia	45.08	28.59	11	2703	2251	90623482
Ocular hypertension	42.99	28.59	10	2704	1670	90624063
Hydrothorax	42.10	28.59	9	2705	1024	90624709
Drug interaction	41.43	28.59	46	2668	276407	90349326
Immune-mediated myositis	39.36	28.59	10	2704	2411	90623322
Angina pectoris	37.97	28.59	20	2694	39140	90586593
Product substitution error	36.57	28.59	5	2709	36	90625697
Cardiac ventricular disorder	36.34	28.59	6	2708	167	90625566
Acute kidney injury	34.37	28.59	45	2669	320342	90305391
Oedema peripheral	33.70	28.59	40	2674	257875	90367858
Lactic acidosis	33.23	28.59	20	2694	50443	90575290
Disorientation	33.03	28.59	19	2695	44095	90581638
Angina unstable	32.58	28.59	11	2703	7132	90618601
Congestive cardiomyopathy	32.26	28.59	11	2703	7343	90618390
Stenosis	30.90	28.59	8	2706	2076	90623657
Left ventricular hypertrophy	30.16	28.59	10	2704	6134	90619599
Hyperreflexia	29.37	28.59	10	2704	6647	90619086
Lipid metabolism disorder	28.90	28.59	5	2709	185	90625548

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	184.01	27.21	124	4453	106732	42510026
Dyspnoea at rest	157.69	27.21	44	4533	4205	42612553
Rales	155.82	27.21	55	4522	11345	42605413
Tricuspid valve incompetence	138.22	27.21	50	4527	11063	42605695
Ejection fraction decreased	136.58	27.21	60	4517	22027	42594731
Diastolic dysfunction	123.99	27.21	41	4536	6942	42609816
Pericardial disease	121.55	27.21	24	4553	498	42616260
Pulmonary valve disease	114.22	27.21	22	4555	399	42616359
Stenosis	102.49	27.21	27	4550	2074	42614684
Mitral valve incompetence	96.12	27.21	43	4534	16446	42600312
Physical examination abnormal	94.14	27.21	19	4558	442	42616316
Coronary artery stenosis	93.85	27.21	37	4540	10342	42606416
Electrocardiogram Q wave abnormal	91.36	27.21	19	4558	515	42616243
Bundle branch block left	91.33	27.21	32	4545	6444	42610314
Acute myocardial infarction	89.20	27.21	63	4514	58102	42558656
Hepatojugular reflux	86.81	27.21	19	4558	660	42616098
Hepatic vein dilatation	81.12	27.21	15	4562	216	42616542
Echocardiogram abnormal	79.94	27.21	20	4557	1250	42615508
Cardiac discomfort	79.80	27.21	18	4559	719	42616039
Occult blood	79.75	27.21	19	4558	967	42615791
Liver palpable	77.31	27.21	15	4562	283	42616475
Hyperlipidaemia	76.52	27.21	40	4537	21476	42595282
Helicobacter gastritis	73.72	27.21	19	4558	1338	42615420
Carotid arteriosclerosis	72.31	27.21	21	4556	2311	42614447
Systolic dysfunction	71.10	27.21	22	4555	3006	42613752
Angina pectoris	70.69	27.21	44	4533	32852	42583906
Ventricular arrhythmia	69.70	27.21	26	4551	6253	42610505
Carotid artery stenosis	69.58	27.21	25	4552	5411	42611347
Mitral valve disease	66.97	27.21	18	4559	1492	42615266
Atrial enlargement	63.93	27.21	15	4562	714	42616044
Left ventricular hypertrophy	63.04	27.21	27	4550	9292	42607466
Inferior vena cava dilatation	62.18	27.21	15	4562	805	42615953
Left ventricular dysfunction	60.70	27.21	28	4549	11473	42605285
Ventricular enlargement	59.62	27.21	14	4563	669	42616089
Linear IgA disease	56.72	27.21	17	4560	2086	42614672
Cardiomegaly	56.28	27.21	30	4547	16736	42600022
Cardiac failure chronic	55.80	27.21	25	4552	9576	42607182
Anaemia macrocytic	55.66	27.21	19	4558	3536	42613222
Supraventricular tachycardia	55.64	27.21	27	4550	12381	42604377
Aortic valve incompetence	54.50	27.21	22	4555	6526	42610232
Ventricular hypokinesia	53.44	27.21	22	4555	6862	42609896
Left ventricular enlargement	51.85	27.21	13	4564	819	42615939
Base excess decreased	50.98	27.21	10	4567	200	42616558
Angiopathy	47.99	27.21	19	4558	5358	42611400
Hypokinesia	42.81	27.21	21	4556	9850	42606908
Oxygen consumption decreased	41.41	27.21	9	4568	302	42616456
Cardiac murmur	35.00	27.21	20	4557	12755	42604003
Coronary artery disease	33.96	27.21	35	4542	53685	42563073
Intestinal obstruction	33.86	27.21	26	4551	27132	42589626
Hypertrophy	31.89	27.21	8	4569	505	42616253
Renal cyst	30.99	27.21	17	4560	10022	42606736
Breath sounds abnormal	30.65	27.21	18	4559	12075	42604683
Chronic kidney disease	30.26	27.21	31	4546	47210	42569548
Electrocardiogram QT prolonged	29.87	27.21	31	4546	47914	42568844
Skin lesion	29.54	27.21	24	4553	27150	42589608
Ventricular tachycardia	29.38	27.21	25	4552	30135	42586623
Mean cell haemoglobin decreased	28.30	27.21	10	4567	2060	42614698
Ill-defined disorder	28.09	27.21	19	4558	16277	42600481
Congestive cardiomyopathy	27.49	27.21	15	4562	8749	42608009

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	251.23	22.80	156	7234	187470	110394439
Rales	168.26	22.80	63	7327	24676	110557233
Dyspnoea at rest	153.27	22.80	45	7345	8301	110573608
Tricuspid valve incompetence	148.64	22.80	57	7333	23816	110558093
Stenosis	142.12	22.80	35	7355	3316	110578593
Pulmonary valve disease	128.12	22.80	22	7368	337	110581572
Ejection fraction decreased	125.23	22.80	59	7331	40821	110541088
Pericardial disease	125.08	22.80	24	7366	699	110581210
Diastolic dysfunction	123.81	22.80	42	7348	12362	110569547
Coronary artery stenosis	123.39	22.80	43	7347	13715	110568194
Cardiac failure chronic	111.79	22.80	40	7350	13771	110568138
Mitral valve incompetence	104.84	22.80	49	7341	33280	110548629
Angina pectoris	104.46	22.80	60	7330	62235	110519674
Physical examination abnormal	100.26	22.80	19	7371	517	110581392
Acute myocardial infarction	100.21	22.80	65	7325	83712	110498197
Ventricular hypokinesia	96.53	22.80	34	7356	11180	110570729
Hepatojugular reflux	94.28	22.80	19	7371	716	110581193
Electrocardiogram Q wave abnormal	94.05	22.80	19	7371	725	110581184
Bundle branch block left	88.25	22.80	33	7357	12855	110569054
Hepatic vein dilatation	87.40	22.80	15	7375	229	110581680
Ventricular arrhythmia	84.60	22.80	30	7360	10057	110571852
Hyperlipidaemia	83.67	22.80	43	7347	35805	110546104
Liver palpable	81.95	22.80	15	7375	336	110581573
Left ventricular dysfunction	81.57	22.80	37	7353	23456	110558453
Cardiomegaly	79.94	22.80	39	7351	29091	110552818
Systolic dysfunction	77.52	22.80	23	7367	4392	110577517
Occult blood	76.75	22.80	19	7371	1837	110580072
Carotid arteriosclerosis	76.52	22.80	21	7369	3036	110578873
Cardiac discomfort	76.43	22.80	18	7372	1410	110580499
Helicobacter gastritis	75.00	22.80	20	7370	2596	110579313
Echocardiogram abnormal	74.56	22.80	20	7370	2654	110579255
Inferior vena cava dilatation	66.79	22.80	15	7375	952	110580957
Left ventricular hypertrophy	66.22	22.80	27	7363	13217	110568692
Tachypnoea	66.16	22.80	38	7352	39357	110542552
Ventricular enlargement	65.41	22.80	14	7376	710	110581199
Mitral valve disease	65.21	22.80	19	7371	3406	110578503
Carotid artery stenosis	64.44	22.80	24	7366	9239	110572670
Atrial enlargement	64.19	22.80	15	7375	1136	110580773
Chronic kidney disease	60.40	22.80	46	7344	76245	110505664
Supraventricular tachycardia	59.03	22.80	30	7360	24392	110557517
Left ventricular enlargement	57.38	22.80	13	7377	858	110581051
Aortic valve incompetence	57.00	22.80	23	7367	10958	110570951
Anaemia macrocytic	54.78	22.80	20	7370	7283	110574626
Linear IgA disease	52.33	22.80	17	7373	4372	110577537
Oedema peripheral	52.27	22.80	85	7305	328575	110253334
Congestive cardiomyopathy	51.28	22.80	23	7367	14196	110567713
Base excess decreased	49.18	22.80	10	7380	394	110581515
Angina unstable	48.10	22.80	23	7367	16409	110565500
Angiopathy	47.79	22.80	19	7371	8711	110573198
Atrial fibrillation	47.28	22.80	67	7323	229575	110352334
Coronary artery disease	43.50	22.80	37	7353	71653	110510256
Blood creatinine increased	41.59	22.80	56	7334	182833	110399076
Oxygen consumption decreased	40.92	22.80	9	7381	519	110581390
Lipohypertrophy	40.10	22.80	10	7380	996	110580913
Perseveration	37.12	22.80	8	7382	419	110581490
Orthopnoea	37.12	22.80	17	7373	11004	110570905
Coronary artery occlusion	37.02	22.80	19	7371	15753	110566156
Drug interaction	36.87	22.80	94	7296	500089	110081820
Ventricular tachycardia	34.90	22.80	28	7362	49981	110531928
Renal cyst	34.49	22.80	19	7371	18153	110563756
Hypokinesia	33.85	22.80	20	7370	21806	110560103
Blood urea increased	32.59	22.80	28	7362	54929	110526980
Electrocardiogram QT prolonged	32.13	22.80	38	7352	108922	110472987
Cardiac murmur	31.62	22.80	20	7370	24608	110557301
Arteriosclerosis	31.52	22.80	20	7370	24747	110557162
Apraxia	31.48	22.80	11	7379	3529	110578380
Ocular hypertension	31.46	22.80	10	7380	2398	110579511
Hypertrophy	30.89	22.80	8	7382	927	110580982
Hydrothorax	30.69	22.80	9	7381	1649	110580260
Arrhythmia	30.63	22.80	30	7360	69545	110512364
Myocardial ischaemia	30.15	22.80	20	7370	26664	110555245
Product substitution error	29.34	22.80	5	7385	73	110581836
Intestinal obstruction	29.31	22.80	26	7364	53201	110528708
Hypertension	28.80	22.80	87	7303	509997	110071912
Breath sounds abnormal	28.61	22.80	19	7371	25385	110556524
Drug ineffective	28.55	22.80	36	7354	1520504	109061405
Diverticulum intestinal haemorrhagic	28.30	22.80	11	7379	4752	110577157
Cardiac ventricular disorder	27.29	22.80	6	7384	345	110581564
Splenomegaly	26.81	22.80	18	7372	24480	110557429
Diabetes mellitus	26.60	22.80	33	7357	99348	110482561
Skin lesion	26.03	22.80	24	7366	51607	110530302
Sideroblastic anaemia	25.82	22.80	6	7384	443	110581466
International normalised ratio decreased	25.54	22.80	12	7378	8224	110573685
Brain natriuretic peptide increased	24.86	22.80	13	7377	11196	110570713
Wrong patient received product	24.71	22.80	11	7379	6663	110575246
Myocardial infarction	24.36	22.80	45	7345	192038	110389871
Arteriosclerosis coronary artery	24.06	22.80	17	7373	25101	110556808
Blood glucose increased	23.40	22.80	36	7354	132460	110449449
Blood bicarbonate decreased	22.90	22.80	10	7380	5787	110576122

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01EB15	CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35610	antineoplastic agent

Related Drugs by ATC class:

C01EB Other cardiac preparations 15 drugs

acadesineacoramidisadenosinecamphorcreatinolfosfateibuprofenindomethacinivabradinemavacamtenmeldoniumphosphocreatineranolazine show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Angina pectoris	indication	194828000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.61	Basic
pKa2	4.61	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carnitine O-palmitoyltransferase 1, muscle isoform	Enzyme		CPT1B_RAT		IC50	5.89		CHEMBL

External reference:

ID	Source
N0000167121	NUI
D01606	KEGG_DRUG
C0041037	UMLSCUI
CHEBI:94789	CHEBI
CHEMBL203266	ChEMBL_ID
DB09069	DRUGBANK_ID
CHEMBL3561076	ChEMBL_ID
D014292	MESH_DESCRIPTOR_UI
21109	PUBCHEM_CID
1544	INN_ID
13171-25-0	SECONDARY_CAS_RN
N9A0A0R9S8	UNII
10826	RXNORM
003771	NDDF
003772	NDDF
1156140000	SNOMEDCT_US
703365009	SNOMEDCT_US
703366005	SNOMEDCT_US
N9A0A0R9S8	INXIGHT DRUGS

Pharmaceutical products:

None