alimemazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2749	84-96-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: alimemazine alimemazine tartrate temaril trimeprazine tartrate trimeprazine alimezine methylpromazine teralene	A phenothiazine derivative that is used as an antipruritic. Molecular weight: 298.45 Formula: C18H22N2S CLOGP: 5 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 6.48 ALOGS: -4.55 ROTB: 4 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

alimemazine
alimemazine tartrate
temaril
trimeprazine tartrate
trimeprazine
alimezine
methylpromazine
teralene

A phenothiazine derivative that is used as an antipruritic.

Molecular weight: 298.45
Formula: C18H22N2S
CLOGP: 5
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 6.48
ALOGS: -4.55
ROTB: 4

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O
30	mg	P

ADMET properties:

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Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	100 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
None	FDA	ALLERGAN HERBERT

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Intentional overdose	1352.03	50.01	428	5601	73724	63409269
Intentional self-injury	1281.12	50.01	326	5703	25361	63457632
Coma	545.91	50.01	211	5818	64153	63418840
Poisoning deliberate	463.43	50.01	123	5906	11095	63471898
Somnolence	264.29	50.01	180	5849	178505	63304488
Toxicity to various agents	175.99	50.01	162	5867	247088	63235905
Depressed level of consciousness	167.30	50.01	92	5937	61986	63421007
Suicide attempt	166.15	50.01	91	5938	60827	63422166
Bradypnoea	156.31	50.01	41	5988	3509	63479484
Tachycardia	155.44	50.01	111	5918	118045	63364948

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	786.35	37.85	267	3897	45411	34907356
Poisoning deliberate	295.66	37.85	84	4080	7760	34945007
Intentional overdose	244.57	37.85	114	4050	43560	34909207
Intentional self-injury	241.19	37.85	82	4082	13689	34939078
Drug abuse	169.17	37.85	119	4045	98977	34853790
Toxicity to various agents	142.27	37.85	145	4019	200217	34752550
Somnolence	102.33	37.85	93	4071	111023	34841744
Miosis	93.18	37.85	37	4127	9498	34943269
Electrocardiogram QT prolonged	83.42	37.85	55	4109	40897	34911870
Poisoning	68.44	37.85	32	4132	12194	34940573

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	1281.96	39.41	470	8940	100179	79634799
Intentional overdose	930.26	39.41	378	9032	105582	79629396
Intentional self-injury	861.30	39.41	264	9146	32155	79702823
Poisoning deliberate	768.11	39.41	214	9196	18614	79716364
Somnolence	362.19	39.41	266	9144	238715	79496263
Toxicity to various agents	290.37	39.41	299	9111	421241	79313737
Drug abuse	232.25	39.41	175	9235	162516	79572462
Electrocardiogram QT prolonged	226.84	39.41	138	9272	90248	79644730
Suicide attempt	191.22	39.41	120	9290	82812	79652166
Tachycardia	164.97	39.41	149	9261	177619	79557359

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	R06AD01	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Phenothiazine derivatives
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D000982	Antipruritics
MeSH PA	D003879	Dermatologic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Dermatographic urticaria	indication	7632005	DOID:743
Angioedema	indication	41291007	DOID:1558
General anesthesia	indication	50697003
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Sneezing	indication	76067001
Urticaria	indication	126485001
Itching of skin	indication	418363000
Allergic conjunctivitis	indication	473460002	DOID:11204

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🐶 Veterinary Drug Use

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Species	Use	Relation
Dogs	Itching	Indication
Dogs	Inflammation	Indication
Dogs	Adjunctive therapy in various cough conditions	Indication
Dogs	Acute or chronic bacterial infections provided the infection is controlled by appropriate antibiotic or chemotherapeutic agents	Indication

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🐶 Veterinary products

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Product	Applicant	Ingredients
Temaril-P Spansule Capsule No. 1, Temaril-P Spansule Capsule No. 2	Zoetis Inc.	2
Temaril-P Tablets	Zoetis Inc.	2

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Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.92	Basic
pKa2	3.55	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST				CHEMBL	CHEMBL
FAD-linked sulfhydryl oxidase ALR	Enzyme	P55789	ALR_HUMAN		AC50	5.90		CHEMBL

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External reference:

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ID	Source
001535	NDDF
001536	NDDF
10825	RXNORM
2318	MMSL
362NW1LD6Z	UNII
387471006	SNOMEDCT_US
4018016	VANDF
4019960	VUID
4019960	VANDF
4330-99-8	SECONDARY_CAS_RN

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Pharmaceutical products:

None