trimebutine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2748	39133-31-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: trimebutine maleate trimebutine (+/-)-Trimebutine	Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders. Molecular weight: 387.48 Formula: C22H29NO5 CLOGP: 4.36 LIPINSKI: 0 HAC: 6 HDO: 0 TPSA: 57.23 ALOGS: -4.31 ROTB: 10

Molecule

Description

Molfile Inchi Smiles

Synonyms:

trimebutine maleate
trimebutine
(+/-)-Trimebutine

Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.

Molecular weight: 387.48
Formula: C22H29NO5
CLOGP: 4.36
LIPINSKI: 0
HAC: 6
HDO: 0
TPSA: 57.23
ALOGS: -4.31
ROTB: 10

Drug dosage:

Dose	Unit	Route
0.60	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyponatraemia	110.74	26.83	66	2735	111834	63374387
Necrosis ischaemic	105.46	26.83	20	2781	840	63485381
Pneumonia streptococcal	90.61	26.83	20	2781	1791	63484430
Beta haemolytic streptococcal infection	88.38	26.83	20	2781	2005	63484216
Coma	61.04	26.83	37	2764	64327	63421894
Colitis microscopic	58.13	26.83	20	2781	9319	63476902
Acute kidney injury	57.30	26.83	64	2737	263351	63222870
Drug reaction with eosinophilia and systemic symptoms	55.70	26.83	28	2773	33808	63452413
Interstitial lung disease	54.64	26.83	34	2767	61874	63424347
Poisoning deliberate	54.55	26.83	20	2781	11198	63475023

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Wrong patient received product	36.93	29.00	11	1876	2643	34952401
Acute kidney injury	34.57	29.00	60	1827	304928	34650116
Encephalopathy	31.39	29.00	21	1866	35298	34919746
Tumour necrosis	30.05	29.00	8	1879	1280	34953764
Mydriasis	29.52	29.00	12	1875	7225	34947819

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Necrosis ischaemic	94.77	23.89	20	4717	1070	79738581
Hyponatraemia	91.01	23.89	79	4658	177769	79561882
Beta haemolytic streptococcal infection	81.74	23.89	20	4717	2077	79737574
Acute kidney injury	78.86	23.89	123	4614	519281	79220370
Pneumonia streptococcal	76.39	23.89	20	4717	2725	79736926
Coma	75.52	23.89	56	4681	100593	79639058
Colitis microscopic	49.53	23.89	20	4717	10748	79728903
Poisoning deliberate	47.71	23.89	23	4714	18805	79720846
Drug reaction with eosinophilia and systemic symptoms	44.27	23.89	34	4703	64210	79675441
Rash maculo-papular	41.56	23.89	31	4706	56047	79683604

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A03AA05	ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, esters with tertiary amino group
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.6	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
003502	NDDF
003503	NDDF
10819	RXNORM
2773	INN_ID
34140-59-5	SECONDARY_CAS_RN
5573	PUBCHEM_CID
698184001	SNOMEDCT_US
703719009	SNOMEDCT_US
C0041023	UMLSCUI
CHEBI:32261	CHEBI

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Pharmaceutical products:

None