Stem definition | Drug id | CAS RN |
---|---|---|
2742 | 146-54-3 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
0.10 | g | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 16, 1957 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | N05AA05 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with aliphatic side-chain |
CHEBI has role | CHEBI:48561 | dopaminergic antagonists |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:65190 | typical antipsychotic drugs |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
MeSH PA | D000932 | Antiemetics |
MeSH PA | D014150 | Antipsychotic Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018492 | Dopamine Antagonists |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Nausea and vomiting | indication | 16932000 | |
Psychotic disorder | indication | 69322001 | |
Vomiting | indication | 422400008 | |
Nausea | indication | 422587007 | |
Alcoholism | contraindication | 7200002 | |
Organophosphate poisoning | contraindication | 8260003 | |
Weight gain finding | contraindication | 8943002 | |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Senile dementia | contraindication | 15662003 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Orthostatic hypotension | contraindication | 28651003 | |
Torsades de pointes | contraindication | 31722008 | |
Parkinsonism | contraindication | 32798002 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Extrapyramidal disease | contraindication | 76349003 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Stupor | contraindication | 89458003 | |
Tardive dyskinesia | contraindication | 102449007 | |
Prolonged QT interval | contraindication | 111975006 | |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Angina pectoris | contraindication | 194828000 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Hyperprolactinemia | contraindication | 237662005 | DOID:12700 |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Coma | contraindication | 371632003 | |
At risk for aspiration | contraindication | 371736008 | |
Visual impairment | contraindication | 397540003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Obesity | contraindication | 414916001 | DOID:9970 |
Congenital long QT syndrome | contraindication | 442917000 | |
Carcinoma of female breast | contraindication | 447782002 |
Species | Use | Relation |
---|---|---|
Dogs | Anxiety | Indication |
Dogs | Control psychomotor overactivity | Indication |
Dogs | Pain and pruritus | Indication |
Cats | Anxiety | Indication |
Cats | Control psychomotor overactivity | Indication |
Cats | Pain and pruritus | Indication |
Horses | Anxiety | Indication |
Horses | Control psychomotor overactivity | Indication |
Horses | Pain and pruritus | Indication |
Product | Applicant | Ingredients |
---|---|---|
Vetame Injectable, Vetame Tablets | Zoetis Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.04 | Basic |
pKa2 | 2.72 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | ANTAGONIST | Ki | 8.55 | PDSP | CHEMBL | |||
Multidrug resistance protein 1 | Transporter | Ki | 4.80 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.40 | PDSP | |||||
Trypanothione reductase | Enzyme | Ki | 4.52 | CHEMBL | |||||
Cholinesterase | Enzyme | IC50 | 5.13 | CHEMBL | |||||
Pleiotropic ABC efflux transporter of multiple drugs | Transporter | IC50 | 5.31 | CHEMBL |
ID | Source |
---|---|
4019958 | VUID |
N0000148043 | NUI |
D00390 | KEGG_DRUG |
1098-60-8 | SECONDARY_CAS_RN |
4017744 | VANDF |
4019958 | VANDF |
C0040989 | UMLSCUI |
CHEBI:9711 | CHEBI |
CHEMBL570 | ChEMBL_ID |
DB00508 | DRUGBANK_ID |
D014273 | MESH_DESCRIPTOR_UI |
5568 | PUBCHEM_CID |
4330 | IUPHAR_LIGAND_ID |
725 | INN_ID |
RO16TQF95Y | UNII |
10805 | RXNORM |
5626 | MMSL |
d03152 | MMSL |
001472 | NDDF |
004589 | NDDF |
30329006 | SNOMEDCT_US |
398816002 | SNOMEDCT_US |
6992002 | SNOMEDCT_US |
CHEMBL1201102 | ChEMBL_ID |
None