trifluperidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antipsychotics, haloperidol derivatives | 2741 | 749-13-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2 | mg | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05AD02 | NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Butyrophenone derivatives |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.36 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | Ki | 9.70 | PDSP | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 9.08 | CHEMBL | |||||
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Enzyme | Ki | 6.78 | CHEMBL | |||||
| D(3) dopamine receptor | GPCR | Ki | 8.46 | PDSP | |||||
| D(4) dopamine receptor | GPCR | Ki | 9.46 | PDSP | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 9.10 | CHEMBL | |||||
| C-8 sterol isomerase | Enzyme | Ki | 9.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166793 | NUI |
| D02625 | KEGG_DRUG |
| C0040988 | UMLSCUI |
| CHEBI:135662 | CHEBI |
| CHEMBL15023 | ChEMBL_ID |
| D014272 | MESH_DESCRIPTOR_UI |
| DB13552 | DRUGBANK_ID |
| 5567 | PUBCHEM_CID |
| 1604 | INN_ID |
| R8869Q7R8I | UNII |
| 10804 | RXNORM |
| 004060 | NDDF |
| 387301006 | SNOMEDCT_US |
| 5478006 | SNOMEDCT_US |
Pharmaceutical products:
None