tridihexethyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2737 60-49-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tridihexethyl
  • tridihexethyl chloride
  • tridihexethyl iodide
synonym Pathilon refers to chloride; RN given refers to parent cpd; structure
  • Molecular weight: 318.52
  • Formula: C21H36NO
  • CLOGP: 1.32
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -7.32
  • ROTB: 8
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.13 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 49
kinase-selectivity-class AXL,CDK4,EIF2AK3,GRK2,PDK4 5
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 15, 1954 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AB08 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, quaternary ammonium compounds
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:53784 antispasmodic drug

Related Drugs by ATC class:

A03AB Synthetic anticholinergics, quaternary ammonium compounds 19 drugs
(2-benzhydryloxyethyl)diethyl-methylammonium iodidebenziloniumbevoniumdiphemanilfenpiveriniumglycopyrronium bromidehexocycliumisopropamidemepenzolatemethantheliniumotilonium bromideoxyphenonium show all 19 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Gastric ulcer indication 397825006 DOID:10808
Irritable bowel syndrome off-label use 10743008 DOID:9778
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Lowered convulsive threshold contraindication 19260006
Substance abuse contraindication 66214007
Kidney disease contraindication 90708001 DOID:557
Seizure disorder contraindication 128613002
Acute intermittent porphyria contraindication 234422006 DOID:3890
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST CHEMBL CHEMBL
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
4019955 VUID
N0000148040 NUI
D00723 KEGG_DRUG
4017914 VANDF
4019955 VANDF
C0077081 UMLSCUI
CHEBI:9701 CHEBI
CHEMBL1201354 ChEMBL_ID
DB00505 DRUGBANK_ID
CHEMBL1200771 ChEMBL_ID
CHEMBL2107686 ChEMBL_ID
C005386 MESH_SUPPLEMENTAL_RECORD_UI
20299 PUBCHEM_CID
4310-35-4 SECONDARY_CAS_RN
125-99-5 SECONDARY_CAS_RN
7HE50A367X UNII
38617 RXNORM
001744 NDDF
004700 NDDF
36872003 SNOMEDCT_US
76787008 SNOMEDCT_US
551 INN_ID
7HE50A367X INXIGHT DRUGS

Pharmaceutical products:

None