triclofos 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
insecticides, anthelminthics, pesticides etc., phosphorous derivatives	2735	306-52-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

triclofos
trichlophos
trichloroethyl dihydrogen phosphate
trichloroethyl phosphate
triclofos sodium

derivative 7 metabolic precursor of trichloroethanol; RN given refers to parent cpd; structure

Molecular weight: 229.37
Formula: C2H4Cl3O4P
CLOGP: -0.11
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 66.76
ALOGS: -1.47
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05CM07	NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Other hypnotics and sedatives

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.37	acidic
pKa2	6.42	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
D00388	KEGG_DRUG
C0077073	UMLSCUI
CHEBI:9695	CHEBI
CHEMBL1201317	ChEMBL_ID
DB06753	DRUGBANK_ID
5563	PUBCHEM_CID
C004345	MESH_SUPPLEMENTAL_RECORD_UI
1518	INN_ID
7246-20-0	SECONDARY_CAS_RN
J712EO9048	UNII
104696	RXNORM
001439	NDDF
004583	NDDF
395914004	SNOMEDCT_US
420762008	SNOMEDCT_US
421583009	SNOMEDCT_US
CHEMBL1200789	ChEMBL_ID

Pharmaceutical products:

None