Stem definition | Drug id | CAS RN |
---|---|---|
steroids not used as glucocorticosteroids | 2726 | 76-25-5 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.11 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.26 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 23 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 9.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 4, 1960 | FDA | APOTHECON |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Injection site atrophy | 264.56 | 11.04 | 61 | 25317 | 482 | 46660202 |
Adrenal insufficiency | 187.37 | 11.04 | 106 | 25272 | 13018 | 46647666 |
Soft tissue disorder | 172.21 | 11.04 | 70 | 25308 | 4116 | 46656568 |
Skin atrophy | 121.10 | 11.04 | 55 | 25323 | 4245 | 46656439 |
Non-infectious endophthalmitis | 115.26 | 11.04 | 26 | 25352 | 184 | 46660500 |
Endophthalmitis | 115.22 | 11.04 | 49 | 25329 | 3229 | 46657455 |
Pneumonia viral | 101.33 | 11.04 | 56 | 25322 | 6568 | 46654116 |
Body height below normal | 94.04 | 11.04 | 36 | 25342 | 1803 | 46658881 |
Synovitis | 92.03 | 11.04 | 138 | 25240 | 60937 | 46599747 |
Arthritis | 89.57 | 11.04 | 155 | 25223 | 77161 | 46583523 |
Human antichimeric antibody positive | 88.51 | 11.04 | 32 | 25346 | 1364 | 46659320 |
Joint destruction | 82.53 | 11.04 | 38 | 25340 | 3026 | 46657658 |
Fibromyalgia | 80.18 | 11.04 | 99 | 25279 | 36364 | 46624320 |
Liver function test abnormal | 80.17 | 11.04 | 112 | 25266 | 46375 | 46614309 |
Blood cholesterol increased | 75.96 | 11.04 | 101 | 25277 | 39912 | 46620772 |
Juvenile idiopathic arthritis | 74.59 | 11.04 | 39 | 25339 | 4093 | 46656591 |
Wheelchair user | 72.84 | 11.04 | 38 | 25340 | 3970 | 46656714 |
Intraocular pressure increased | 71.48 | 11.04 | 43 | 25335 | 5914 | 46654770 |
Obesity | 70.79 | 11.04 | 60 | 25318 | 14146 | 46646538 |
Toxicity to various agents | 67.73 | 11.04 | 16 | 25362 | 211750 | 46448934 |
Polyarthritis | 62.82 | 11.04 | 41 | 25337 | 6501 | 46654183 |
Hypothalamic pituitary adrenal axis suppression | 61.80 | 11.04 | 15 | 25363 | 151 | 46660533 |
Cushing's syndrome | 57.48 | 11.04 | 20 | 25358 | 761 | 46659923 |
Bone density decreased | 56.58 | 11.04 | 45 | 25333 | 9707 | 46650977 |
Antibody test positive | 55.67 | 11.04 | 26 | 25352 | 2139 | 46658545 |
Bursitis infective | 49.49 | 11.04 | 20 | 25358 | 1157 | 46659527 |
Retinal artery occlusion | 49.41 | 11.04 | 21 | 25357 | 1381 | 46659303 |
Rhegmatogenous retinal detachment | 48.87 | 11.04 | 11 | 25367 | 77 | 46660607 |
Urticarial vasculitis | 46.86 | 11.04 | 15 | 25363 | 439 | 46660245 |
Psoriasis | 46.76 | 11.04 | 120 | 25258 | 78484 | 46582200 |
Necrotising scleritis | 46.28 | 11.04 | 12 | 25366 | 161 | 46660523 |
Ocular hypertension | 45.89 | 11.04 | 17 | 25361 | 777 | 46659907 |
Visual acuity reduced | 45.35 | 11.04 | 58 | 25320 | 22055 | 46638629 |
Herpes zoster | 44.99 | 11.04 | 108 | 25270 | 67764 | 46592920 |
Death | 44.66 | 11.04 | 71 | 25307 | 335477 | 46325207 |
Secondary adrenocortical insufficiency | 44.28 | 11.04 | 17 | 25361 | 858 | 46659826 |
Adrenal suppression | 42.90 | 11.04 | 17 | 25361 | 934 | 46659750 |
Retinal pigment epithelial tear | 42.25 | 11.04 | 12 | 25366 | 231 | 46660453 |
Acute kidney injury | 40.62 | 11.04 | 41 | 25337 | 235814 | 46424870 |
Maculopathy | 40.35 | 11.04 | 19 | 25359 | 1592 | 46659092 |
Injection site discolouration | 40.33 | 11.04 | 32 | 25346 | 6878 | 46653806 |
Eye infection toxoplasmal | 39.83 | 11.04 | 12 | 25366 | 286 | 46660398 |
Postmenopausal haemorrhage | 39.22 | 11.04 | 20 | 25358 | 1993 | 46658691 |
Drug specific antibody | 35.11 | 11.04 | 16 | 25362 | 1244 | 46659440 |
Lipoatrophy | 33.92 | 11.04 | 11 | 25367 | 336 | 46660348 |
Soft tissue swelling | 33.48 | 11.04 | 14 | 25364 | 884 | 46659800 |
Macular degeneration | 32.99 | 11.04 | 29 | 25349 | 7176 | 46653508 |
Intentional product use issue | 32.86 | 11.04 | 82 | 25296 | 52698 | 46607986 |
Chorioretinopathy | 32.57 | 11.04 | 13 | 25365 | 728 | 46659956 |
Atrophy | 31.92 | 11.04 | 16 | 25362 | 1537 | 46659147 |
Gastroenteritis viral | 31.73 | 11.04 | 44 | 25334 | 18075 | 46642609 |
Tractional retinal detachment | 31.22 | 11.04 | 7 | 25371 | 48 | 46660636 |
Immunodeficiency | 31.10 | 11.04 | 37 | 25341 | 13069 | 46647615 |
Leukopenia | 30.48 | 11.04 | 94 | 25284 | 68249 | 46592435 |
Therapeutic product effect incomplete | 29.89 | 11.04 | 102 | 25276 | 78051 | 46582633 |
Human anti-human antibody test | 29.76 | 11.04 | 10 | 25368 | 342 | 46660342 |
Tenderness | 28.09 | 11.04 | 40 | 25338 | 16841 | 46643843 |
Product contamination | 25.49 | 11.04 | 10 | 25368 | 535 | 46660149 |
Eye inflammation | 25.19 | 11.04 | 19 | 25359 | 3790 | 46656894 |
Hypopyon | 24.83 | 11.04 | 11 | 25367 | 800 | 46659884 |
Dermatitis contact | 24.52 | 11.04 | 26 | 25352 | 8097 | 46652587 |
Cushingoid | 24.34 | 11.04 | 23 | 25355 | 6243 | 46654441 |
Drug abuse | 24.16 | 11.04 | 3 | 25375 | 63405 | 46597279 |
Orbital infection | 23.81 | 11.04 | 5 | 25373 | 24 | 46660660 |
Spinal cord infarction | 23.41 | 11.04 | 8 | 25370 | 288 | 46660396 |
Renal impairment | 23.01 | 11.04 | 6 | 25372 | 74366 | 46586318 |
Scleral thinning | 22.88 | 11.04 | 5 | 25373 | 30 | 46660654 |
Red blood cell sedimentation rate increased | 22.79 | 11.04 | 43 | 25335 | 22846 | 46637838 |
Skin discolouration | 22.72 | 11.04 | 53 | 25325 | 32627 | 46628057 |
Therapy non-responder | 22.59 | 11.04 | 61 | 25317 | 41091 | 46619593 |
Polypoidal choroidal vasculopathy | 22.10 | 11.04 | 6 | 25372 | 97 | 46660587 |
Blindness | 21.79 | 11.04 | 36 | 25342 | 17233 | 46643451 |
Muscle atrophy | 21.42 | 11.04 | 21 | 25357 | 5963 | 46654721 |
Conjunctival ulcer | 21.41 | 11.04 | 5 | 25373 | 42 | 46660642 |
Bradycardia | 21.18 | 11.04 | 5 | 25373 | 66293 | 46594391 |
Keratitis fungal | 20.95 | 11.04 | 6 | 25372 | 119 | 46660565 |
Overdose | 20.86 | 11.04 | 15 | 25363 | 101964 | 46558720 |
Infection | 20.78 | 11.04 | 134 | 25244 | 133458 | 46527226 |
Intentional overdose | 20.55 | 11.04 | 5 | 25373 | 64939 | 46595745 |
Vitreous opacities | 20.43 | 11.04 | 7 | 25371 | 254 | 46660430 |
Retinal scar | 19.72 | 11.04 | 6 | 25372 | 148 | 46660536 |
Peripheral vascular disorder | 19.60 | 11.04 | 20 | 25358 | 5957 | 46654727 |
Peripheral swelling | 19.58 | 11.04 | 150 | 25228 | 157921 | 46502763 |
Thrombocytopenia | 19.57 | 11.04 | 24 | 25354 | 126557 | 46534127 |
Exposure via breast milk | 19.50 | 11.04 | 11 | 25367 | 1341 | 46659343 |
Epicondylitis | 19.42 | 11.04 | 12 | 25366 | 1730 | 46658954 |
Acute febrile neutrophilic dermatosis | 19.12 | 11.04 | 14 | 25364 | 2671 | 46658013 |
Injection site fibrosis | 19.09 | 11.04 | 4 | 25374 | 19 | 46660665 |
Systemic lupus erythematosus | 18.79 | 11.04 | 6 | 25372 | 65174 | 46595510 |
Pseudoendophthalmitis | 18.45 | 11.04 | 4 | 25374 | 23 | 46660661 |
Detachment of retinal pigment epithelium | 18.33 | 11.04 | 7 | 25371 | 348 | 46660336 |
Vitreous disorder | 18.30 | 11.04 | 5 | 25373 | 83 | 46660601 |
Septic shock | 18.27 | 11.04 | 71 | 25307 | 57822 | 46602862 |
Skin hypopigmentation | 18.24 | 11.04 | 7 | 25371 | 353 | 46660331 |
Bone density increased | 18.16 | 11.04 | 7 | 25371 | 357 | 46660327 |
Oral pain | 18.10 | 11.04 | 41 | 25337 | 24756 | 46635928 |
Conjunctival haemorrhage | 17.81 | 11.04 | 14 | 25364 | 2967 | 46657717 |
Intra-abdominal haematoma | 17.59 | 11.04 | 11 | 25367 | 1620 | 46659064 |
Coma | 17.50 | 11.04 | 5 | 25373 | 58344 | 46602340 |
Purpura senile | 17.49 | 11.04 | 8 | 25370 | 627 | 46660057 |
Infective scleritis | 17.48 | 11.04 | 3 | 25375 | 3 | 46660681 |
Eye infection fungal | 17.28 | 11.04 | 5 | 25373 | 103 | 46660581 |
Retinal haemorrhage | 17.23 | 11.04 | 17 | 25361 | 4866 | 46655818 |
Hypocalcaemia | 17.07 | 11.04 | 42 | 25336 | 26743 | 46633941 |
Injection site abscess | 16.82 | 11.04 | 9 | 25369 | 990 | 46659694 |
Injection site necrosis | 16.77 | 11.04 | 10 | 25368 | 1352 | 46659332 |
Product use issue | 16.64 | 11.04 | 98 | 25280 | 94546 | 46566138 |
Joint effusion | 16.49 | 11.04 | 26 | 25352 | 11969 | 46648715 |
Pyloric abscess | 16.26 | 11.04 | 3 | 25375 | 6 | 46660678 |
Staphylococcal infection | 15.75 | 11.04 | 49 | 25329 | 35722 | 46624962 |
Rhinitis allergic | 15.57 | 11.04 | 19 | 25359 | 6889 | 46653795 |
Drug specific antibody present | 15.49 | 11.04 | 13 | 25365 | 3023 | 46657661 |
Rapidly progressive osteoarthritis | 15.40 | 11.04 | 3 | 25375 | 9 | 46660675 |
Bronchiectasis | 15.39 | 11.04 | 22 | 25356 | 9294 | 46651390 |
Pemphigus | 15.31 | 11.04 | 3 | 25375 | 45271 | 46615413 |
Parakeratosis | 15.08 | 11.04 | 5 | 25373 | 164 | 46660520 |
Arthritis bacterial | 14.95 | 11.04 | 17 | 25361 | 5719 | 46654965 |
Chorioretinal folds | 14.94 | 11.04 | 3 | 25375 | 11 | 46660673 |
Neutropenia | 14.90 | 11.04 | 35 | 25343 | 143169 | 46517515 |
Dermatophytosis | 14.82 | 11.04 | 5 | 25373 | 173 | 46660511 |
Retinal detachment | 14.82 | 11.04 | 16 | 25362 | 5084 | 46655600 |
Infusion related reaction | 14.80 | 11.04 | 20 | 25358 | 101188 | 46559496 |
Cardio-respiratory arrest | 14.80 | 11.04 | 7 | 25371 | 59862 | 46600822 |
Impaired quality of life | 14.74 | 11.04 | 13 | 25365 | 3229 | 46657455 |
Tarsal tunnel syndrome | 14.21 | 11.04 | 7 | 25371 | 648 | 46660036 |
Short stature | 14.20 | 11.04 | 5 | 25373 | 197 | 46660487 |
Retinal artery embolism | 14.13 | 11.04 | 4 | 25374 | 76 | 46660608 |
Loss of personal independence in daily activities | 14.06 | 11.04 | 65 | 25313 | 57118 | 46603566 |
General physical health deterioration | 13.98 | 11.04 | 26 | 25352 | 115743 | 46544941 |
Diabetic ulcer | 13.76 | 11.04 | 5 | 25373 | 216 | 46660468 |
Cardiac failure | 13.62 | 11.04 | 14 | 25364 | 79934 | 46580750 |
Bursitis | 13.60 | 11.04 | 32 | 25346 | 19810 | 46640874 |
Iridoschisis | 13.59 | 11.04 | 3 | 25375 | 19 | 46660665 |
Upper respiratory tract infection bacterial | 13.58 | 11.04 | 4 | 25374 | 88 | 46660596 |
Quality of life decreased | 13.36 | 11.04 | 16 | 25362 | 5686 | 46654998 |
Skin depigmentation | 13.28 | 11.04 | 7 | 25371 | 746 | 46659938 |
Resorption bone increased | 13.17 | 11.04 | 8 | 25370 | 1119 | 46659565 |
Rotator cuff syndrome | 13.10 | 11.04 | 23 | 25355 | 11560 | 46649124 |
Cardiac arrest | 13.08 | 11.04 | 18 | 25360 | 90381 | 46570303 |
Injection site scar | 13.05 | 11.04 | 7 | 25371 | 773 | 46659911 |
Steroid withdrawal syndrome | 12.94 | 11.04 | 6 | 25372 | 485 | 46660199 |
Hyponatraemia | 12.91 | 11.04 | 22 | 25356 | 101310 | 46559374 |
Seizure | 12.86 | 11.04 | 30 | 25348 | 123024 | 46537660 |
Somnolence | 12.77 | 11.04 | 43 | 25335 | 156478 | 46504206 |
Arthralgia | 12.73 | 11.04 | 273 | 25105 | 364330 | 46296354 |
Ear discomfort | 12.72 | 11.04 | 17 | 25361 | 6744 | 46653940 |
Pruritus | 12.51 | 11.04 | 193 | 25185 | 242159 | 46418525 |
Retinal degeneration | 12.45 | 11.04 | 6 | 25372 | 529 | 46660155 |
Necrotising retinitis | 12.39 | 11.04 | 5 | 25373 | 288 | 46660396 |
Pancytopenia | 12.24 | 11.04 | 17 | 25361 | 85041 | 46575643 |
Metabolic acidosis | 12.24 | 11.04 | 3 | 25375 | 38777 | 46621907 |
Osteoporosis | 12.16 | 11.04 | 49 | 25329 | 40559 | 46620125 |
Flushing | 12.07 | 11.04 | 68 | 25310 | 64546 | 46596138 |
Hyperadrenocorticism | 12.00 | 11.04 | 5 | 25373 | 313 | 46660371 |
Spinal cord ischaemia | 11.96 | 11.04 | 3 | 25375 | 35 | 46660649 |
Incorrect route of product administration | 11.86 | 11.04 | 27 | 25351 | 16356 | 46644328 |
C-reactive protein increased | 11.84 | 11.04 | 63 | 25315 | 58527 | 46602157 |
Maternal exposure during pregnancy | 11.54 | 11.04 | 24 | 25354 | 102525 | 46558159 |
Cataract subcapsular | 11.44 | 11.04 | 6 | 25372 | 633 | 46660051 |
Phantom limb syndrome | 11.35 | 11.04 | 4 | 25374 | 158 | 46660526 |
Gingival blister | 11.32 | 11.04 | 3 | 25375 | 44 | 46660640 |
Glossodynia | 11.26 | 11.04 | 5 | 25373 | 44368 | 46616316 |
Electrocardiogram QT prolonged | 11.23 | 11.04 | 7 | 25371 | 51318 | 46609366 |
Joint injury | 11.07 | 11.04 | 29 | 25349 | 19180 | 46641504 |
Cytomegalovirus chorioretinitis | 11.05 | 11.04 | 8 | 25370 | 1499 | 46659185 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Endophthalmitis | 306.82 | 12.45 | 92 | 10467 | 3388 | 29938531 |
Visual acuity reduced | 177.32 | 12.45 | 94 | 10465 | 15752 | 29926167 |
Non-infectious endophthalmitis | 148.56 | 12.45 | 29 | 10530 | 152 | 29941767 |
Intraocular pressure increased | 121.33 | 12.45 | 51 | 10508 | 5069 | 29936850 |
Ocular hypertension | 111.55 | 12.45 | 30 | 10529 | 738 | 29941181 |
Maculopathy | 84.63 | 12.45 | 25 | 10534 | 871 | 29941048 |
Uveitis | 83.24 | 12.45 | 40 | 10519 | 5437 | 29936482 |
Chorioretinopathy | 80.61 | 12.45 | 27 | 10532 | 1425 | 29940494 |
Choroiditis | 77.56 | 12.45 | 23 | 10536 | 812 | 29941107 |
Eye infection toxoplasmal | 65.41 | 12.45 | 15 | 10544 | 186 | 29941733 |
Macular oedema | 63.94 | 12.45 | 27 | 10532 | 2711 | 29939208 |
Hypothalamic pituitary adrenal axis suppression | 59.15 | 12.45 | 14 | 10545 | 201 | 29941718 |
Eye pain | 57.07 | 12.45 | 41 | 10518 | 11748 | 29930171 |
Adrenal suppression | 56.90 | 12.45 | 17 | 10542 | 616 | 29941303 |
Injection site atrophy | 52.12 | 12.45 | 10 | 10549 | 47 | 29941872 |
Eye inflammation | 51.51 | 12.45 | 20 | 10539 | 1617 | 29940302 |
Retinal artery occlusion | 50.96 | 12.45 | 20 | 10539 | 1664 | 29940255 |
Infective scleritis | 48.69 | 12.45 | 8 | 10551 | 11 | 29941908 |
Hypopyon | 48.14 | 12.45 | 14 | 10545 | 461 | 29941458 |
Intentional product use issue | 46.98 | 12.45 | 61 | 10498 | 36379 | 29905540 |
Glaucoma | 46.87 | 12.45 | 28 | 10531 | 5880 | 29936039 |
Dermatitis contact | 44.30 | 12.45 | 22 | 10537 | 3209 | 29938710 |
Macular fibrosis | 41.62 | 12.45 | 12 | 10547 | 383 | 29941536 |
Diabetic retinal oedema | 40.72 | 12.45 | 11 | 10548 | 275 | 29941644 |
Toxicity to various agents | 40.29 | 12.45 | 7 | 10552 | 177176 | 29764743 |
Product contamination | 39.76 | 12.45 | 13 | 10546 | 636 | 29941283 |
Cystoid macular oedema | 39.07 | 12.45 | 13 | 10546 | 672 | 29941247 |
Retinal haemorrhage | 36.39 | 12.45 | 22 | 10537 | 4721 | 29937198 |
Retinal artery embolism | 35.20 | 12.45 | 7 | 10552 | 41 | 29941878 |
Necrotising retinitis | 34.45 | 12.45 | 12 | 10547 | 713 | 29941206 |
Psoriasis | 32.89 | 12.45 | 56 | 10503 | 42450 | 29899469 |
Product use issue | 30.93 | 12.45 | 57 | 10502 | 45959 | 29895960 |
Skin hypopigmentation | 30.87 | 12.45 | 9 | 10550 | 299 | 29941620 |
Symmetrical drug-related intertriginous and flexural exanthema | 30.76 | 12.45 | 8 | 10551 | 172 | 29941747 |
Retinal detachment | 30.14 | 12.45 | 20 | 10539 | 5040 | 29936879 |
Subretinal fluid | 28.82 | 12.45 | 8 | 10551 | 222 | 29941697 |
Retinal pigment epithelial tear | 27.88 | 12.45 | 8 | 10551 | 251 | 29941668 |
Uveitis-glaucoma-hyphaema syndrome | 26.72 | 12.45 | 5 | 10554 | 20 | 29941899 |
Choroidal infarction | 25.23 | 12.45 | 6 | 10553 | 88 | 29941831 |
Distal intestinal obstruction syndrome | 25.17 | 12.45 | 8 | 10551 | 357 | 29941562 |
Visual field defect | 25.14 | 12.45 | 17 | 10542 | 4419 | 29937500 |
Blindness | 24.91 | 12.45 | 26 | 10533 | 12283 | 29929636 |
Adrenal insufficiency | 24.66 | 12.45 | 24 | 10535 | 10439 | 29931480 |
Anaphylactic reaction | 24.52 | 12.45 | 39 | 10520 | 27943 | 29913976 |
Cauda equina syndrome | 24.49 | 12.45 | 8 | 10551 | 390 | 29941529 |
Vitreous opacities | 24.23 | 12.45 | 7 | 10552 | 225 | 29941694 |
Expired product administered | 23.81 | 12.45 | 14 | 10545 | 2855 | 29939064 |
Pseudoendophthalmitis | 23.36 | 12.45 | 5 | 10554 | 44 | 29941875 |
Injection site calcification | 22.80 | 12.45 | 4 | 10555 | 10 | 29941909 |
Completed suicide | 22.44 | 12.45 | 4 | 10555 | 99488 | 29842431 |
Open globe injury | 22.02 | 12.45 | 4 | 10555 | 13 | 29941906 |
Vitritis | 20.34 | 12.45 | 8 | 10551 | 669 | 29941250 |
Spinal cord infarction | 19.96 | 12.45 | 6 | 10553 | 222 | 29941697 |
Rhegmatogenous retinal detachment | 19.89 | 12.45 | 4 | 10555 | 25 | 29941894 |
Anterior chamber inflammation | 19.44 | 12.45 | 6 | 10553 | 243 | 29941676 |
Cataract subcapsular | 19.34 | 12.45 | 6 | 10553 | 247 | 29941672 |
Retinal degeneration | 19.03 | 12.45 | 6 | 10553 | 261 | 29941658 |
Central vision loss | 18.92 | 12.45 | 4 | 10555 | 33 | 29941886 |
Cataract | 18.53 | 12.45 | 30 | 10529 | 21805 | 29920114 |
Arthritis bacterial | 18.18 | 12.45 | 14 | 10545 | 4450 | 29937469 |
Eye abscess | 17.51 | 12.45 | 5 | 10554 | 154 | 29941765 |
Pain | 17.30 | 12.45 | 112 | 10447 | 172529 | 29769390 |
Drug abuse | 17.05 | 12.45 | 4 | 10555 | 82068 | 29859851 |
Arthritis infective | 16.87 | 12.45 | 11 | 10548 | 2691 | 29939228 |
Amblyopia | 16.74 | 12.45 | 4 | 10555 | 60 | 29941859 |
Cardiac arrest | 16.59 | 12.45 | 6 | 10553 | 92844 | 29849075 |
Cushing's syndrome | 15.80 | 12.45 | 6 | 10553 | 456 | 29941463 |
Lenticular opacities | 15.73 | 12.45 | 5 | 10554 | 223 | 29941696 |
Vision blurred | 15.71 | 12.45 | 41 | 10518 | 41775 | 29900144 |
Oesophageal perforation | 15.67 | 12.45 | 6 | 10553 | 467 | 29941452 |
Mycobacterium kansasii infection | 15.61 | 12.45 | 5 | 10554 | 229 | 29941690 |
Retinal oedema | 15.08 | 12.45 | 6 | 10553 | 517 | 29941402 |
Application site pruritus | 14.87 | 12.45 | 8 | 10551 | 1375 | 29940544 |
Intracranial hypotension | 14.83 | 12.45 | 5 | 10554 | 269 | 29941650 |
Visual impairment | 14.83 | 12.45 | 33 | 10526 | 30405 | 29911514 |
Subretinal fibrosis | 14.73 | 12.45 | 4 | 10555 | 102 | 29941817 |
Incorrect route of product administration | 14.66 | 12.45 | 19 | 10540 | 11296 | 29930623 |
Drug ineffective | 14.42 | 12.45 | 183 | 10376 | 340204 | 29601715 |
Dermatitis | 14.37 | 12.45 | 16 | 10543 | 8126 | 29933793 |
Rash | 14.32 | 12.45 | 116 | 10443 | 191773 | 29750146 |
Vitrectomy | 14.11 | 12.45 | 4 | 10555 | 120 | 29941799 |
Death | 13.83 | 12.45 | 72 | 10487 | 357211 | 29584708 |
Cellulitis orbital | 13.69 | 12.45 | 5 | 10554 | 341 | 29941578 |
Skin burning sensation | 13.56 | 12.45 | 11 | 10548 | 3769 | 29938150 |
Skin exfoliation | 13.47 | 12.45 | 27 | 10532 | 23145 | 29918774 |
Chondritis | 13.18 | 12.45 | 4 | 10555 | 153 | 29941766 |
Dry skin | 12.85 | 12.45 | 26 | 10533 | 22428 | 29919491 |
Cushingoid | 12.84 | 12.45 | 9 | 10550 | 2478 | 29939441 |
Rash pruritic | 12.76 | 12.45 | 26 | 10533 | 22546 | 29919373 |
Stomatitis | 12.45 | 12.45 | 35 | 10524 | 37244 | 29904675 |
Source | Code | Description |
---|---|---|
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:50857 | anti-allergic agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Cerebral edema | indication | 2032001 | |
Lichen planus | indication | 4776004 | DOID:9201 |
Berylliosis | indication | 8247009 | DOID:10322 |
Psoriasis | indication | 9014002 | DOID:8893 |
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Rheumatic heart disease | indication | 23685000 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
Multiple sclerosis | indication | 24700007 | DOID:2377 |
Severe adrenal insufficiency | indication | 24867002 | |
Sarcoidosis | indication | 31541009 | DOID:11335 |
Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
Psoriasis with arthropathy | indication | 33339001 | |
Keloid scar | indication | 33659008 | |
Crohn's disease | indication | 34000006 | |
Tendinitis | indication | 34840004 | DOID:971 |
Erythema multiforme | indication | 36715001 | |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Angioedema | indication | 41291007 | DOID:1558 |
Humoral hypercalcemia of malignancy | indication | 47709007 | |
Articular gout | indication | 48440001 | DOID:13189 |
Candidiasis of skin | indication | 49883006 | |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Edema of larynx | indication | 51599000 | |
Nephrotic syndrome | indication | 52254009 | DOID:1184 |
Lichen simplex chronicus | indication | 53891004 | |
Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
Allergic rhinitis | indication | 61582004 | |
Löffler's syndrome | indication | 64936001 | DOID:9503 |
Pemphigus | indication | 65172003 | DOID:9182 |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Tenosynovitis | indication | 67801009 | DOID:970 |
Alopecia areata | indication | 68225006 | DOID:986 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Transfusion reaction due to serum protein reaction | indication | 72284000 | |
Epicondylitis | indication | 73583000 | DOID:14087 |
Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
Sympathetic uveitis | indication | 75315001 | DOID:12029 |
Thyroiditis | indication | 82119001 | DOID:7166 |
Bursitis | indication | 84017003 | DOID:2965 |
Autoimmune disease | indication | 85828009 | |
Infection by larvae of Trichinella spiralis | indication | 88264003 | |
Pruritus ani | indication | 90446007 | |
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Subacute bursitis | indication | 109298000 | |
Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Mycosis fungoides | indication | 118618005 | |
Uveitis | indication | 128473001 | DOID:13141 |
Aspiration pneumonitis | indication | 155597006 | |
Asthma | indication | 195967001 | DOID:2841 |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Transplanted organ rejection | indication | 213148006 | |
Scalp psoriasis | indication | 238608008 | |
Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Seasonal allergic rhinitis | indication | 367498001 | |
Disorder of eye | indication | 371405004 | DOID:5614 |
Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
Erythroderma | indication | 399992009 | |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Asthma management | indication | 406162001 | |
Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
Giant cell arteritis | indication | 414341000 | DOID:13375 |
Synovitis | indication | 416209007 | DOID:2703 |
Aphthous ulcer of mouth | indication | 426965005 | DOID:9663 |
Post traumatic osteoarthritis | indication | 699262001 | |
Severe Ocular Inflammation | indication | ||
Chronic Non-Allergic Rhinitis | indication | ||
Cystic Aponeurosis Tumor | indication | ||
Systemic Dermatomyositis | indication | ||
Allergic Rhinitis Prevention | indication | ||
Gingival Disorders | indication | ||
Erythroblastic Anemia | indication | ||
Transfusion Reaction Urticaria | indication | ||
Vitrectomy Adjunct to Enhance Visualization | indication | ||
Synovitis due to Osteoarthritis | indication | ||
Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
Congenital hypoplastic anemia | off-label use | 88854002 | DOID:1339 |
Severe chronic obstructive pulmonary disease | off-label use | 313299006 | |
Neonatal Bronchopulmonary Dysplasia | off-label use | ||
Infection by Strongyloides | contraindication | 1214006 | DOID:10955 |
Mycosis | contraindication | 3218000 | DOID:1564 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Inactive tuberculosis | contraindication | 11999007 | |
Epistaxis | contraindication | 12441001 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hypercholesterolemia | contraindication | 13644009 | |
Measles | contraindication | 14189004 | DOID:8622 |
Disease caused by parasite | contraindication | 17322007 | |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Arginase deficiency | contraindication | 23501004 | DOID:9278 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Acute tuberculosis | contraindication | 25629007 | |
Fungal infection of eye | contraindication | 31194008 | |
Immunosuppression | contraindication | 38013005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Herpes zoster keratoconjunctivitis | contraindication | 42448002 | |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Tuberculosis of eye | contraindication | 49107007 | |
Cerebral malaria | contraindication | 53622003 | DOID:14069 |
Tuberculosis | contraindication | 56717001 | |
Congenital hyperammonemia, type I | contraindication | 62522004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Candidiasis of mouth | contraindication | 79740000 | DOID:14262 |
Perforation of nasal septum | contraindication | 80142000 | |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Bacterial infectious disease | contraindication | 87628006 | |
Muscle atrophy | contraindication | 88092000 | DOID:767 |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Operation on nose | contraindication | 88733004 | |
Bilateral cataracts | contraindication | 95722004 | |
Seizure disorder | contraindication | 128613002 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Anastomosis of intestine | contraindication | 235407009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Telangiectasia disorder | contraindication | 247479008 | |
Edema | contraindication | 267038008 | |
Pathological fracture | contraindication | 268029009 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Cerebral trauma | contraindication | 275382005 | |
Oral infection | contraindication | 275393007 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Viral eye infection | contraindication | 312132001 | |
Osteopenia | contraindication | 312894000 | |
Skin irritation | contraindication | 367466007 | |
Herpes zoster keratitis | contraindication | 397573005 | |
Avascular necrosis of bone | contraindication | 397758007 | DOID:10159 |
Citrullinemia | contraindication | 398680004 | DOID:9273 |
Atrophoderma | contraindication | 399979006 | |
Traumatic rupture of tendon | contraindication | 415749005 | |
Exposure to varicella | contraindication | 444453009 | |
Nasal Septal Ulcers | contraindication | ||
Ornithine Carbamyltransferase Deficiency | contraindication | ||
Periodontal Infections | contraindication | ||
Nasal Candidiasis | contraindication | ||
Nasal Trauma | contraindication | ||
Oropharyngeal Candidiasis | contraindication | ||
Uncontrolled Bacterial Infections | contraindication | ||
Untreated Fungal Infection | contraindication | ||
Arginosuccinate Lyase Deficiency | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.08 | acidic |
pKa2 | 11.78 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | EC50 | 9.30 | WOMBAT-PK | CHEMBL | |||
Annexin A1 | Cytosolic other | WOMBAT-PK | |||||||
Progesterone receptor | Transcription factor | Ki | 7.64 | DRUG MATRIX |
ID | Source |
---|---|
D00983 | KEGG_DRUG |
4017597 | VANDF |
C2608734 | UMLSCUI |
CHEBI:71418 | CHEBI |
1TA | PDB_CHEM_ID |
CHEMBL1504 | ChEMBL_ID |
6436 | PUBCHEM_CID |
D014222 | MESH_DESCRIPTOR_UI |
F446C597KA | UNII |
2867 | IUPHAR_LIGAND_ID |
DB00620 | DRUGBANK_ID |
10761 | RXNORM |
2967 | MMSL |
5614 | MMSL |
6440 | MMSL |
002189 | NDDF |
395913005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
KENULLLOG-40 | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0003-0293 | INJECTION, SUSPENSION | 40 mg | INTRAMUSCULAR | NDA | 21 sections |
KENULLLOG-80 | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0003-0315 | INJECTION, SUSPENSION | 80 mg | INTRAMUSCULAR | NDA | 21 sections |
KENULLLOG-10 | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0003-0494 | INJECTION, SUSPENSION | 10 mg | INTRA-ARTICULAR | NDA | 22 sections |
TRIESENCE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0543 | INJECTION, SUSPENSION | 40 mg | OPHTHALMIC | NDA | 23 sections |
Good Sense Nasal Allergy | HUMAN OTC DRUG LABEL | 1 | 0113-0443 | SPRAY, METERED | 55 ug | NULLSAL | ANDA | 16 sections |
basic care nasal allergy | HUMAN OTC DRUG LABEL | 1 | 0113-7005 | SPRAY, METERED | 55 ug | NULLSAL | ANDA | 15 sections |
triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0002 | CREAM | 5 mg | TOPICAL | ANDA | 17 sections |
triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0003 | CREAM | 0.25 mg | TOPICAL | ANDA | 17 sections |
triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0004 | CREAM | 1 mg | TOPICAL | ANDA | 17 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0005 | OINTMENT | 0.25 mg | TOPICAL | ANDA | 19 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0006 | OINTMENT | 1 mg | TOPICAL | ANDA | 19 sections |
Nystatin and Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0168-0081 | CREAM | 1 mg | TOPICAL | ANDA | 16 sections |
Nystatin and Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0168-0089 | OINTMENT | 1 mg | TOPICAL | ANDA | 19 sections |
triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0336 | LOTION | 0.25 mg | TOPICAL | ANDA | 17 sections |
triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0337 | LOTION | 1 mg | TOPICAL | ANDA | 17 sections |
TRIDERM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0165 | CREAM | 0.25 mg | TOPICAL | ANDA | 18 sections |
TRIDERM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0170 | CREAM | 1 mg | TOPICAL | ANDA | 18 sections |
TRIDERM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0316-0175 | CREAM | 5 mg | TOPICAL | ANDA | 18 sections |
Nystatin and Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0316-0223 | CREAM | 1 mg | TOPICAL | ANDA | 18 sections |
Allergy Nasal | HUMAN OTC DRUG LABEL | 1 | 0363-0811 | SPRAY, METERED | 55 ug | NULLSAL | ANDA | 16 sections |
Triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-0251 | CREAM | 1 mg | TOPICAL | ANDA | 18 sections |
Triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-0317 | CREAM | 0.25 mg | TOPICAL | ANDA | 17 sections |
Triamcinolone acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-0318 | CREAM | 5 mg | TOPICAL | ANDA | 17 sections |
Nystatin and Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0472-0150 | CREAM | 1 mg | TOPICAL | ANDA | 11 sections |
Nystatin and Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0472-0155 | OINTMENT | 1 mg | TOPICAL | ANDA | 11 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-0241 | INJECTION, SUSPENSION | 40 mg | INTRA-ARTICULAR | ANDA | 20 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-0243 | INJECTION, SUSPENSION | 40 mg | INTRA-ARTICULAR | ANDA | 20 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0703-0245 | INJECTION, SUSPENSION | 40 mg | INTRA-ARTICULAR | ANDA | 20 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0225 | CREAM | 1 mg | TOPICAL | ANDA | 18 sections |
Triamcinolone Acetonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0713-0226 | CREAM | 0.25 mg | TOPICAL | ANDA | 18 sections |