triamcinolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 2725 124-94-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triamcinolone
  • triamcinlon
  • triamcinolon
  • rodinolone
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
  • Molecular weight: 394.44
  • Formula: C21H27FO6
  • CLOGP: 0.71
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 115.06
  • ALOGS: -2.67
  • ROTB: 2
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
7.50 mg P
0.22 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 23 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 3, 1957 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 404.26 14.29 284 16697 92408 56182678
Adrenal insufficiency 387.61 14.29 154 16827 15543 56259543
Body height below normal 257.98 14.29 69 16912 1954 56273132
Human antichimeric antibody positive 231.35 14.29 60 16921 1503 56273583
Polyarthritis 213.17 14.29 85 16896 8643 56266443
Dermatitis atopic 189.48 14.29 77 16904 8222 56266864
Obesity 187.14 14.29 104 16877 22344 56252742
Juvenile idiopathic arthritis 176.60 14.29 63 16918 4710 56270376
Wheelchair user 171.93 14.29 64 16917 5402 56269684
Joint destruction 169.36 14.29 62 16919 4993 56270093
Bone density decreased 142.86 14.29 72 16909 12688 56262398
Drug specific antibody 122.73 14.29 39 16942 2041 56273045
Antibody test positive 104.94 14.29 36 16945 2395 56272691
Septic shock 98.47 14.29 106 16875 60729 56214357
Therapy non-responder 90.80 14.29 102 16879 61253 56213833
Gastroenteritis viral 89.72 14.29 63 16918 20361 56254725
Immunodeficiency 83.24 14.29 55 16926 16102 56258984
Ankle arthroplasty 68.43 14.29 23 16958 1437 56273649
Hypothalamic pituitary adrenal axis suppression 65.70 14.29 14 16967 143 56274943
Product dose omission issue 63.21 14.29 169 16812 204584 56070502
Hypocalcaemia 60.94 14.29 58 16923 28702 56246384
Product use in unapproved indication 60.37 14.29 132 16849 140690 56134396
Mobility decreased 57.05 14.29 105 16876 98886 56176200
Red blood cell sedimentation rate increased 56.07 14.29 62 16919 36561 56238525
Arthritis 55.16 14.29 104 16877 99748 56175338
Diarrhoea 53.61 14.29 352 16629 638155 55636931
Injection site atrophy 53.60 14.29 15 16966 504 56274582
Drug ineffective for unapproved indication 51.02 14.29 50 16931 25643 56249443
Bursitis infective 50.85 14.29 18 16963 1314 56273772
Quality of life decreased 48.94 14.29 29 16952 7016 56268070
Eye infection toxoplasmal 47.27 14.29 12 16969 275 56274811
Macular degeneration 45.61 14.29 41 16940 18867 56256219
Condition aggravated 45.46 14.29 215 16766 344683 55930403
Foot operation 41.46 14.29 25 16956 6242 56268844
Eczema 41.28 14.29 45 16936 26108 56248978
Skin atrophy 40.51 14.29 22 16959 4508 56270578
Chorioretinopathy 38.54 14.29 13 16968 821 56274265
Nausea 37.63 14.29 373 16608 763805 55511281
Adrenal suppression 37.57 14.29 13 16968 887 56274199
Red blood cell sedimentation rate abnormal 36.44 14.29 36 16945 18637 56256449
Mycotic endophthalmitis 36.00 14.29 7 16974 43 56275043
Impaired quality of life 34.58 14.29 25 16956 8449 56266637
Human anti-human antibody test 33.42 14.29 10 16971 427 56274659
Loss of personal independence in daily activities 33.39 14.29 75 16906 81294 56193792
Pleural effusion 32.01 14.29 76 16905 85404 56189682
Steroid withdrawal syndrome 31.27 14.29 10 16971 534 56274552
Rhegmatogenous retinal detachment 30.43 14.29 7 16974 104 56274982
Off label use 30.02 14.29 277 16704 555903 55719183
Tractional retinal detachment 29.58 14.29 6 16975 47 56275039
Nodule 29.32 14.29 32 16949 18587 56256499
Synovitis 29.32 14.29 111 16870 161194 56113892
Necrotising fasciitis 29.29 14.29 15 16966 2730 56272356
Plastic surgery 28.74 14.29 6 16975 55 56275031
C-reactive protein increased 28.43 14.29 69 16912 78615 56196471
Microsporidia infection 28.41 14.29 8 16973 275 56274811
Necrotising scleritis 27.85 14.29 7 16974 154 56274932
Drug ineffective 27.41 14.29 408 16573 918581 55356505
Skin odour abnormal 27.38 14.29 12 16969 1543 56273543
Hepatic enzyme increased 27.02 14.29 9 16972 171375 56103711
Staphylococcal infection 27.01 14.29 44 16937 37574 56237512
Perioral dermatitis 26.62 14.29 7 16974 185 56274901
Bone density increased 26.61 14.29 9 16972 573 56274513
Toxicity to various agents 25.96 14.29 18 16963 224546 56050540
Pyloric abscess 25.66 14.29 4 16977 4 56275082
Short stature 25.16 14.29 8 16973 419 56274667
Rapidly progressive osteoarthritis 24.76 14.29 4 16977 6 56275080
Dystrophic calcification 24.70 14.29 6 16975 114 56274972
Foot deformity 24.51 14.29 33 16948 23792 56251294
Retinal artery occlusion 24.29 14.29 11 16970 1527 56273559
Cushingoid 23.96 14.29 19 16962 7365 56267721
Infectious crystalline keratopathy 22.41 14.29 4 16977 14 56275072
Lower respiratory tract infection 22.02 14.29 4 16977 114790 56160296
Intentional product use issue 21.85 14.29 73 16908 99660 56175426
Product contamination microbial 21.34 14.29 6 16975 205 56274881
Birdshot chorioretinopathy 20.74 14.29 5 16976 92 56274994
Drug tolerance 20.70 14.29 16 16965 5978 56269108
General physical health deterioration 20.49 14.29 13 16968 169997 56105089
Alopecia universalis 20.49 14.29 5 16976 97 56274989
Limb discomfort 20.29 14.29 32 16949 26590 56248496
Dermatitis contact 19.77 14.29 19 16962 9508 56265578
Joint swelling 19.56 14.29 36 16945 289764 55985322
Ocular hypertension 19.33 14.29 8 16973 893 56274193
Articular calcification 19.28 14.29 5 16976 125 56274961
Peripheral vascular disorder 19.16 14.29 15 16966 5710 56269376
Wound 19.07 14.29 9 16972 138795 56136291
Joint effusion 19.06 14.29 23 16958 14875 56260211
Intraocular pressure increased 18.89 14.29 15 16966 5826 56269260
Hypokalaemia 18.83 14.29 67 16914 94370 56180716
Non-infectious endophthalmitis 18.57 14.29 5 16976 145 56274941
Cross sensitivity reaction 18.57 14.29 10 16971 2015 56273071
Cystoid macular oedema 18.14 14.29 9 16972 1532 56273554
Skin discolouration 17.98 14.29 35 16946 34321 56240765
Rash 17.89 14.29 227 16754 492820 55782266
Dry skin 17.75 14.29 42 16939 47067 56228019
Pulmonary fibrosis 17.67 14.29 32 16949 29726 56245360
Retinal exudates 17.65 14.29 7 16974 700 56274386
Choroiditis 17.59 14.29 5 16976 178 56274908
Keratitis fungal 17.53 14.29 5 16976 180 56274906
Tendon rupture 17.44 14.29 16 16965 7554 56267532
Prescribed underdose 17.42 14.29 26 16955 20591 56254495
Deposit eye 17.16 14.29 3 16978 9 56275077
Death 16.95 14.29 50 16931 341376 55933710
Arthritis fungal 15.95 14.29 3 16978 15 56275071
Infusion related reaction 15.90 14.29 24 16957 208907 56066179
Exposure during pregnancy 15.65 14.29 11 16970 136331 56138755
Squamous cell carcinoma of skin 15.63 14.29 13 16968 5389 56269697
Cataract subcapsular 15.42 14.29 6 16975 571 56274515
Bronchiectasis 15.20 14.29 18 16963 11416 56263670
Pemphigus 15.19 14.29 15 16966 157197 56117889
Maternal exposure during pregnancy 15.18 14.29 21 16960 189532 56085554
Pruritus 15.18 14.29 154 16827 316469 55958617
Shared psychotic disorder 14.97 14.29 3 16978 22 56275064
Lipoatrophy 14.93 14.29 5 16976 309 56274777
Confusional state 14.81 14.29 25 16956 208130 56066956
Dizziness 14.40 14.29 175 16806 375965 55899121

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 191.93 16.72 127 7573 46592 31643052
Dermatitis atopic 109.28 16.72 42 7658 4820 31684824
Product dose omission issue 89.84 16.72 119 7581 105467 31584177
Deposit eye 79.37 16.72 13 7687 31 31689613
Mycotic endophthalmitis 77.98 16.72 14 7686 67 31689577
Rash 73.36 16.72 155 7545 201331 31488313
Product compounding quality issue 62.59 16.72 10 7690 19 31689625
Pruritus 59.69 16.72 108 7592 125059 31564585
Drug ineffective 55.17 16.72 215 7485 395358 31294286
Product contamination microbial 49.46 16.72 14 7686 613 31689031
Steroid withdrawal syndrome 46.57 16.72 11 7689 232 31689412
Ocular hypertension 46.23 16.72 14 7686 778 31688866
Transmission of an infectious agent via product 44.43 16.72 10 7690 169 31689475
Cystoid macular oedema 43.47 16.72 13 7687 692 31688952
Endophthalmitis 43.41 16.72 20 7680 3596 31686048
Eczema 40.45 16.72 32 7668 15385 31674259
Non-infectious endophthalmitis 39.88 16.72 9 7691 154 31689490
Chorioretinopathy 38.02 16.72 14 7686 1425 31688219
Off label use 36.86 16.72 174 7526 347100 31342544
Perioral dermatitis 36.82 16.72 8 7692 114 31689530
Visual acuity reduced 36.34 16.72 30 7670 15313 31674331
Adrenal insufficiency 34.77 16.72 27 7673 12632 31677012
Myoclonic epilepsy 33.80 16.72 12 7688 1100 31688544
Product use in unapproved indication 33.30 16.72 74 7626 99097 31590547
Glaucoma 32.72 16.72 20 7680 6360 31683284
Skin exfoliation 31.98 16.72 34 7666 23840 31665804
Eye infection toxoplasmal 31.27 16.72 8 7692 237 31689407
Intraocular pressure increased 31.14 16.72 18 7682 5169 31684475
Rhegmatogenous retinal detachment 31.11 16.72 6 7694 45 31689599
Retinal scar 29.88 16.72 8 7692 284 31689360
Chondritis 29.62 16.72 7 7693 148 31689496
Adrenal suppression 28.95 16.72 9 7691 546 31689098
Dry skin 28.47 16.72 33 7667 25448 31664196
Pneumonia lipoid 28.42 16.72 6 7694 74 31689570
Retinal oedema 28.13 16.72 9 7691 600 31689044
Skin fissures 25.77 16.72 15 7685 4365 31685279
Sleep disorder 24.35 16.72 31 7669 26317 31663327
Toxicity to various agents 22.52 16.72 8 7692 181479 31508165
Shared psychotic disorder 22.48 16.72 4 7696 18 31689626
Injection site plaque 21.97 16.72 3 7697 0 31689644
Eye infection syphilitic 21.97 16.72 3 7697 0 31689644
Application site pruritus 21.40 16.72 9 7691 1301 31688343
Infective scleritis 21.38 16.72 4 7696 25 31689619
Therapy non-responder 21.15 16.72 33 7667 33778 31655866
Hypothalamic pituitary adrenal axis suppression 19.85 16.72 5 7695 139 31689505
Drug ineffective for unapproved indication 19.80 16.72 23 7677 17767 31671877
Skin discolouration 19.70 16.72 22 7678 16285 31673359
Retinal artery occlusion 19.02 16.72 9 7691 1717 31687927
Intracranial hypotension 17.57 16.72 5 7695 223 31689421
Surgery 16.97 16.72 18 7682 12581 31677063
Meningitis aseptic 16.96 16.72 10 7690 2978 31686666
Retinal deposits 16.77 16.72 3 7697 14 31689630

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 448.46 13.59 305 20223 98128 70809788
Adrenal insufficiency 370.12 13.59 169 20359 25026 70882890
Dermatitis atopic 231.55 13.59 90 20438 8917 70898999
Human antichimeric antibody positive 226.80 13.59 58 20470 1432 70906484
Body height below normal 222.34 13.59 60 20468 1835 70906081
Polyarthritis 189.50 13.59 82 20446 10674 70897242
Joint destruction 165.13 13.59 59 20469 4619 70903297
Obesity 153.56 13.59 96 20432 26675 70881241
Wheelchair user 140.76 13.59 54 20474 5160 70902756
Juvenile idiopathic arthritis 138.66 13.59 55 20473 5745 70902171
Bone density decreased 128.77 13.59 64 20464 11410 70896506
Drug specific antibody 119.81 13.59 39 20489 2300 70905616
Mycotic endophthalmitis 109.15 13.59 21 20507 127 70907789
Product dose omission issue 99.32 13.59 204 20324 217264 70690652
Therapy non-responder 97.97 13.59 116 20412 76799 70831117
Gastroenteritis viral 93.93 13.59 65 20463 21390 70886526
Deposit eye 93.78 13.59 16 20512 42 70907874
Immunodeficiency 88.38 13.59 58 20470 17497 70890419
Drug ineffective 80.20 13.59 504 20024 939248 69968668
Antibody test positive 74.77 13.59 28 20500 2503 70905413
Hypothalamic pituitary adrenal axis suppression 72.75 13.59 17 20511 284 70907632
Eye infection toxoplasmal 72.38 13.59 19 20509 521 70907395
Steroid withdrawal syndrome 71.53 13.59 20 20508 699 70907217
Adrenal suppression 71.10 13.59 23 20505 1329 70906587
Chorioretinopathy 70.81 13.59 26 20502 2199 70905717
Off label use 70.55 13.59 410 20118 742650 70165266
Product use in unapproved indication 70.42 13.59 173 20355 207305 70700611
Ankle arthroplasty 69.81 13.59 22 20506 1168 70906748
Product compounding quality issue 69.41 13.59 12 20516 35 70907881
Product contamination microbial 67.00 13.59 20 20508 884 70907032
Ocular hypertension 66.48 13.59 22 20506 1366 70906550
Drug ineffective for unapproved indication 64.36 13.59 67 20461 38471 70869445
Perioral dermatitis 61.93 13.59 15 20513 294 70907622
Eczema 56.89 13.59 59 20469 33722 70874194
Non-infectious endophthalmitis 56.23 13.59 14 20514 309 70907607
Septic shock 54.36 13.59 108 20420 112150 70795766
Injection site atrophy 53.86 13.59 14 20514 369 70907547
Transmission of an infectious agent via product 52.81 13.59 12 20516 176 70907740
Cystoid macular oedema 51.91 13.59 20 20508 1932 70905984
Toxicity to various agents 50.12 13.59 24 20504 382148 70525768
Arthritis 49.54 13.59 96 20432 97884 70810032
Mobility decreased 48.56 13.59 98 20430 102901 70805015
Rhegmatogenous retinal detachment 48.37 13.59 11 20517 162 70907754
Endophthalmitis 47.79 13.59 27 20501 6228 70901688
Red blood cell sedimentation rate increased 45.44 13.59 56 20472 38586 70869330
Hypocalcaemia 44.88 13.59 60 20468 44799 70863117
Retinal artery occlusion 43.58 13.59 20 20508 2986 70904930
Condition aggravated 43.04 13.59 240 20288 427395 70480521
Diarrhoea 41.48 13.59 376 20152 782965 70124951
Skin atrophy 41.32 13.59 23 20505 5156 70902760
Necrotising scleritis 40.68 13.59 10 20518 209 70907707
Foot operation 39.93 13.59 22 20506 4835 70903081
Completed suicide 38.92 13.59 9 20519 227126 70680790
Shared psychotic disorder 36.72 13.59 7 20521 40 70907876
Intraocular pressure increased 36.70 13.59 26 20502 8875 70899041
Red blood cell sedimentation rate abnormal 34.83 13.59 35 20493 19268 70888648
Human anti-human antibody test 34.22 13.59 10 20518 410 70907506
Rash 33.86 13.59 258 20270 510304 70397612
Visual acuity reduced 33.68 13.59 41 20487 27889 70880027
Cushingoid 33.43 13.59 24 20504 8364 70899552
Loss of personal independence in daily activities 32.21 13.59 74 20454 84836 70823080
Nausea 31.79 13.59 381 20147 851707 70056209
Rapidly progressive osteoarthritis 30.60 13.59 5 20523 9 70907907
Retinal scar 30.19 13.59 9 20519 396 70907520
Synovitis 30.11 13.59 94 20434 129134 70778782
Impaired quality of life 29.90 13.59 23 20505 8893 70899023
Bone density increased 29.88 13.59 10 20518 643 70907273
General physical health deterioration 29.16 13.59 16 20512 236015 70671901
Staphylococcal infection 29.05 13.59 54 20474 53350 70854566
Plastic surgery 28.25 13.59 6 20522 63 70907853
Foot deformity 27.68 13.59 32 20496 20623 70887293
Retinal oedema 26.98 13.59 10 20518 868 70907048
Quality of life decreased 26.51 13.59 21 20507 8474 70899442
Pruritus 25.95 13.59 180 20348 345380 70562536
Pyloric abscess 25.82 13.59 4 20524 4 70907912
Short stature 25.54 13.59 8 20520 416 70907500
Nodule 25.20 13.59 30 20498 19939 70887977
Dry skin 24.90 13.59 52 20476 55879 70852037
Dystrophic calcification 24.20 13.59 6 20522 130 70907786
Glaucoma 24.19 13.59 28 20500 18064 70889852
Intentional product use issue 24.04 13.59 83 20445 120059 70787857
Bursitis infective 23.42 13.59 10 20518 1258 70906658
Chondritis 23.35 13.59 6 20522 151 70907765
Pneumonia lipoid 22.87 13.59 6 20522 164 70907752
Cataract subcapsular 22.85 13.59 9 20519 922 70906994
Cataract 22.78 13.59 50 20478 55595 70852321
Lipoatrophy 22.23 13.59 8 20520 639 70907277
Skin odour abnormal 22.19 13.59 11 20517 1948 70905968
Infectious crystalline keratopathy 21.78 13.59 4 20524 18 70907898
Uveitis 21.59 13.59 24 20504 14821 70893095
Skin exfoliation 21.40 13.59 45 20483 48581 70859335
Limb discomfort 21.36 13.59 34 20494 29671 70878245
Tractional retinal detachment 21.26 13.59 5 20523 86 70907830
Macular oedema 21.10 13.59 15 20513 5147 70902769
Joint effusion 20.78 13.59 24 20504 15453 70892463
Hypotony of eye 20.56 13.59 6 20522 245 70907671
Birdshot chorioretinopathy 20.55 13.59 5 20523 100 70907816
Cauda equina syndrome 20.35 13.59 9 20519 1233 70906683
Necrotising fasciitis 20.18 13.59 15 20513 5511 70902405
Dermatitis contact 20.06 13.59 19 20509 9730 70898186
Infective scleritis 20.04 13.59 4 20524 30 70907886
Choroiditis 19.94 13.59 9 20519 1292 70906624
Microsporidia infection 19.68 13.59 8 20520 890 70907026
Skin discolouration 19.37 13.59 37 20491 37288 70870628
Pleural effusion 19.36 13.59 83 20445 132781 70775135
Retinal artery embolism 19.19 13.59 5 20523 133 70907783
Eye infection syphilitic 18.90 13.59 3 20525 4 70907912
Intentional overdose 18.75 13.59 3 20525 98432 70809484
Application site pruritus 18.37 13.59 12 20516 3589 70904327
Drug abuse 18.15 13.59 10 20518 147246 70760670
Lower respiratory tract infection 18.07 13.59 5 20523 111908 70796008
Dermatitis 17.94 13.59 25 20503 19392 70888524
Tendon rupture 17.89 13.59 19 20509 11150 70896766
Macular fibrosis 17.80 13.59 7 20521 714 70907202
Rash pruritic 17.70 13.59 49 20479 62942 70844974
Acute kidney injury 17.69 13.59 74 20454 474550 70433366
Bradycardia 17.61 13.59 7 20521 124608 70783308
Squamous cell carcinoma of skin 17.55 13.59 20 20508 12692 70895224
Articular calcification 17.53 13.59 5 20523 188 70907728
Hepatic enzyme increased 17.49 13.59 12 20516 156978 70750938
Alopecia universalis 17.25 13.59 5 20523 199 70907717
Extraskeletal ossification 16.78 13.59 4 20524 73 70907843
Confusional state 16.59 13.59 36 20492 284362 70623554
Cross sensitivity reaction 16.31 13.59 11 20517 3467 70904449
Lenticular opacities 16.11 13.59 6 20522 528 70907388
Injection site plaque 16.08 13.59 4 20524 88 70907828
Depressed level of consciousness 15.92 13.59 3 20525 87428 70820488
Psoriatic arthropathy 15.90 13.59 48 20480 64723 70843193
Type I hypersensitivity 15.61 13.59 11 20517 3721 70904195
Product use issue 15.46 13.59 97 20431 179840 70728076
Cardio-respiratory arrest 15.34 13.59 5 20523 100672 70807244
Electrocardiogram QT prolonged 14.92 13.59 3 20525 83514 70824402
Hyperadrenocorticism 14.89 13.59 5 20523 325 70907591
Keratitis fungal 14.86 13.59 5 20523 327 70907589
Retinal detachment 14.63 13.59 15 20513 8452 70899464
Skin plaque 14.55 13.59 16 20512 9767 70898149
Retinal exudates 14.54 13.59 7 20521 1163 70906753
Drug tolerance 14.39 13.59 14 20514 7414 70900502
Infective tenosynovitis 14.29 13.59 5 20523 368 70907548
Pulmonary fibrosis 14.23 13.59 31 20497 34279 70873637
Arthropathy 14.23 13.59 83 20445 149974 70757942
Parakeratosis 14.16 13.59 5 20523 378 70907538
Extradural abscess 14.08 13.59 7 20521 1248 70906668
Intracranial hypotension 14.07 13.59 5 20523 385 70907531
Application site pain 13.99 13.59 11 20517 4391 70903525
Retinal haemorrhage 13.95 13.59 14 20514 7696 70900220
Hypoglycaemia 13.83 13.59 5 20523 94359 70813557

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AC01 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA12 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB09 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07BB03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
ATC D07CB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC H02AB08 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD11 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA06 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S02CA04 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Lichen planus indication 4776004 DOID:9201
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Candidiasis of skin indication 49883006
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Necrobiosis lipoidica diabeticorum indication 56391002
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Alopecia areata indication 68225006 DOID:986
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Sympathetic uveitis indication 75315001 DOID:12029
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Subacute bursitis indication 109298000
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Asthma management indication 406162001
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Giant cell arteritis indication 414341000 DOID:13375
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Post traumatic osteoarthritis indication 699262001
Cystic Aponeurosis Tumor indication
Erythroblastic Anemia indication
Diagnostic Test for Cushing's Syndrome indication
Chronic Non-Allergic Rhinitis indication
Transfusion Reaction Urticaria indication
Severe Ocular Inflammation indication
Gingival Disorders indication
Vitrectomy Adjunct to Enhance Visualization indication
Allergic Rhinitis Prevention indication
Systemic Dermatomyositis indication
Synovitis due to Osteoarthritis indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Severe chronic obstructive pulmonary disease off-label use 313299006
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Neonatal Bronchopulmonary Dysplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Fungal infection of eye contraindication 31194008
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Herpes zoster keratoconjunctivitis contraindication 42448002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Candidiasis of mouth contraindication 79740000 DOID:14262
Perforation of nasal septum contraindication 80142000
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Bacterial infectious disease contraindication 87628006
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Oral infection contraindication 275393007
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Osteopenia contraindication 312894000
Skin irritation contraindication 367466007
Herpes zoster keratitis contraindication 397573005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication
Oropharyngeal Candidiasis contraindication
Nasal Candidiasis contraindication
Periodontal Infections contraindication
Nasal Trauma contraindication
Untreated Fungal Infection contraindication
Nasal Septal Ulcers contraindication
Uncontrolled Bacterial Infections contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.2 acidic
pKa2 11.84 acidic
pKa3 13.18 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 7.59 DRUG MATRIX CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Progesterone receptor Nuclear hormone receptor WOMBAT-PK

External reference:

IDSource
4017599 VUID
N0000145980 NUI
D00385 KEGG_DRUG
4017599 VANDF
C0040864 UMLSCUI
CHEBI:9667 CHEBI
CHEMBL1451 ChEMBL_ID
D014221 MESH_DESCRIPTOR_UI
DB00620 DRUGBANK_ID
31307 PUBCHEM_CID
2870 IUPHAR_LIGAND_ID
755 INN_ID
1ZK20VI6TY UNII
10759 RXNORM
4582 MMSL
5613 MMSL
d00620 MMSL
002188 NDDF
116594009 SNOMEDCT_US
6028009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRIAMCINOLONE ACETONIDE Human Prescription Drug Label 1 67877-470 CREAM 0.25 mg TOPICAL ANDA 17 sections
TRIAMCINOLONE ACETONIDE Human Prescription Drug Label 1 67877-471 CREAM 1 mg TOPICAL ANDA 17 sections
TRIAMCINOLONE ACETONIDE Human Prescription Drug Label 1 67877-472 CREAM 5 mg TOPICAL ANDA 17 sections
Naltrexone HUMAN PRESCRIPTION DRUG LABEL 2 69364-3143 IMPLANT 6.50 mg SUBCUTANEOUS Unapproved drug other 25 sections