triamcinolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 2725 124-94-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triamcinolone
  • triamcinlon
  • triamcinolon
  • rodinolone
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
  • Molecular weight: 394.44
  • Formula: C21H27FO6
  • CLOGP: 0.71
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 115.06
  • ALOGS: -2.67
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
7.50 mg P
0.22 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.08 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability) 23 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 3, 1957 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Adrenal insufficiency 366.51 14.13 143 14759 14100 50576122
Psoriasis 359.70 14.13 234 14668 68766 50521456
Body height below normal 257.41 14.13 68 14834 1881 50588341
Human antichimeric antibody positive 230.77 14.13 59 14843 1430 50588792
Polyarthritis 187.75 14.13 75 14827 7852 50582370
Obesity 185.18 14.13 93 14809 16682 50573540
Wheelchair user 153.29 14.13 57 14845 4915 50585307
Bone density decreased 151.13 14.13 71 14831 11004 50579218
Joint destruction 151.12 14.13 53 14849 3863 50586359
Drug specific antibody 124.41 14.13 38 14864 1787 50588435
Antibody test positive 103.63 14.13 35 14867 2276 50587946
Septic shock 88.16 14.13 96 14806 57079 50533143
Therapy non-responder 79.23 14.13 86 14816 50936 50539286
Dermatitis atopic 74.85 14.13 31 14871 3555 50586667
Gastroenteritis viral 70.12 14.13 52 14850 18734 50571488
Red blood cell sedimentation rate increased 66.82 14.13 61 14841 29355 50560867
Immunodeficiency 66.74 14.13 46 14856 14782 50575440
Hypothalamic pituitary adrenal axis suppression 60.69 14.13 13 14889 140 50590082
Mobility decreased 57.09 14.13 92 14810 79856 50510366
Product dose omission issue 56.29 14.13 149 14753 183689 50406533
Diarrhoea 56.03 14.13 329 14573 588147 50002075
Ankle arthroplasty 53.96 14.13 18 14884 1126 50589096
Quality of life decreased 52.68 14.13 29 14873 6254 50583968
Bursitis infective 52.62 14.13 18 14884 1216 50589006
Arthritis 49.05 14.13 90 14812 86631 50503591
Hypocalcaemia 48.40 14.13 49 14853 26767 50563455
Eye infection toxoplasmal 47.85 14.13 12 14890 268 50589954
Injection site atrophy 45.05 14.13 13 14889 501 50589721
Skin atrophy 42.36 14.13 22 14880 4223 50585999
Condition aggravated 40.61 14.13 184 14718 296874 50293348
Product use in unapproved indication 38.63 14.13 97 14805 115722 50474500
Synovitis 38.48 14.13 101 14801 123764 50466458
Mycotic endophthalmitis 36.60 14.13 7 14895 40 50590182
C-reactive protein increased 35.09 14.13 67 14835 66407 50523815
Chorioretinopathy 35.03 14.13 12 14890 814 50589408
Adrenal suppression 34.40 14.13 12 14890 860 50589362
Nausea 33.87 14.13 336 14566 705062 49885160
Drug ineffective for unapproved indication 33.23 14.13 36 14866 21245 50568977
Rhegmatogenous retinal detachment 32.22 14.13 7 14895 81 50590141
Steroid withdrawal syndrome 31.82 14.13 10 14892 517 50589705
Necrotising fasciitis 30.38 14.13 15 14887 2589 50587633
Human anti-human antibody test 30.04 14.13 9 14893 396 50589826
Tractional retinal detachment 29.84 14.13 6 14896 46 50590176
Foot operation 29.38 14.13 19 14883 5491 50584731
Plastic surgery 28.89 14.13 6 14896 55 50590167
Necrotising scleritis 28.69 14.13 7 14895 139 50590083
Bone density increased 28.68 14.13 9 14893 463 50589759
Staphylococcal infection 28.20 14.13 43 14859 35573 50554649
Perioral dermatitis 28.19 14.13 7 14895 150 50590072
Loss of personal independence in daily activities 28.03 14.13 63 14839 69987 50520235
Cushingoid 26.16 14.13 19 14883 6626 50583596
Pleural effusion 25.87 14.13 67 14835 81387 50508835
Dystrophic calcification 24.94 14.13 6 14896 112 50590110
Rapidly progressive osteoarthritis 24.86 14.13 4 14898 6 50590216
Short stature 23.29 14.13 7 14895 311 50589911
Eczema 23.26 14.13 31 14871 22671 50567551
Intentional product use issue 23.13 14.13 62 14840 76856 50513366
Articular calcification 22.85 14.13 5 14897 60 50590162
Red blood cell sedimentation rate abnormal 22.69 14.13 26 14876 16317 50573905
Birdshot chorioretinopathy 22.48 14.13 5 14897 65 50590157
Infusion related reaction 22.34 14.13 11 14891 169546 50420676
Toxicity to various agents 22.22 14.13 18 14884 212481 50377741
Skin odour abnormal 21.82 14.13 10 14892 1462 50588760
Retinal artery occlusion 21.73 14.13 10 14892 1477 50588745
Product contamination microbial 21.51 14.13 6 14896 204 50590018
Impaired quality of life 20.90 14.13 16 14886 6040 50584182
Keratitis fungal 20.75 14.13 5 14897 94 50590128
Psoriatic arthropathy 20.74 14.13 44 14858 46988 50543234
Ocular hypertension 20.44 14.13 8 14894 792 50589430
Off label use 20.29 14.13 221 14681 474205 50116017
Peripheral vascular disorder 20.09 14.13 15 14887 5452 50584770
Drug ineffective 20.02 14.13 345 14557 818988 49771234
Intraocular pressure increased 19.98 14.13 15 14887 5501 50584721
Dermatitis contact 19.76 14.13 18 14884 8628 50581594
Choroiditis 19.68 14.13 5 14897 118 50590104
Pyloric abscess 19.31 14.13 3 14899 3 50590219
Cross sensitivity reaction 19.06 14.13 10 14892 1959 50588263
Non-infectious endophthalmitis 18.86 14.13 5 14897 140 50590082
Tendon rupture 18.57 14.13 16 14886 7128 50583094
Joint effusion 18.56 14.13 21 14881 13000 50577222
Deposit eye 18.10 14.13 3 14899 6 50590216
Hepatic enzyme increased 17.96 14.13 9 14893 137371 50452851
General physical health deterioration 17.64 14.13 10 14892 142424 50447798
Exposure during pregnancy 17.27 14.13 7 14895 121008 50469214
Nodule 17.09 14.13 23 14879 16980 50573242
Macular degeneration 16.86 14.13 21 14881 14367 50575855
Foot deformity 16.35 14.13 24 14878 19186 50571036
Lower respiratory tract infection 16.27 14.13 4 14898 95197 50495025
Skin discolouration 16.04 14.13 32 14870 32725 50557497
Arthritis fungal 16.02 14.13 3 14899 15 50590207
Cataract subcapsular 15.68 14.13 6 14896 559 50589663
Pemphigus 15.52 14.13 8 14894 120158 50470064
Shared psychotic disorder 15.42 14.13 3 14899 19 50590203
Death 15.42 14.13 47 14855 325332 50264890
Bronchiectasis 15.36 14.13 17 14885 10266 50579956
Prescribed underdose 15.16 14.13 21 14881 15928 50574294
Dizziness 15.07 14.13 162 14740 346207 50244015
Lipoatrophy 15.06 14.13 5 14897 308 50589914
Hypokalaemia 14.68 14.13 58 14844 87934 50502288
Retinal exudates 14.53 14.13 6 14896 682 50589540
Glossodynia 14.47 14.13 8 14894 115561 50474661
Squamous cell carcinoma of skin 14.29 14.13 12 14890 5166 50585056

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 165.59 15.96 100 6899 32127 29535401
Mycotic endophthalmitis 86.26 15.96 14 6985 32 29567496
Product dose omission issue 84.84 15.96 109 6890 96274 29471254
Deposit eye 76.82 15.96 12 6987 19 29567509
Dermatitis atopic 68.30 15.96 24 6975 2195 29565333
Product compounding quality issue 62.86 15.96 10 6989 19 29567509
Rash 56.84 15.96 133 6866 189686 29377842
Product contamination microbial 50.18 15.96 14 6985 597 29566931
Ocular hypertension 47.87 15.96 14 6985 708 29566820
Pruritus 47.76 15.96 93 6906 116756 29450772
Steroid withdrawal syndrome 47.60 15.96 11 6988 216 29567312
Transmission of an infectious agent via product 44.69 15.96 10 6989 169 29567359
Drug ineffective 44.27 15.96 186 6813 362984 29204544
Non-infectious endophthalmitis 41.17 15.96 9 6990 136 29567392
Eczema 37.59 15.96 29 6970 13797 29553731
Perioral dermatitis 37.03 15.96 8 6991 114 29567414
Visual acuity reduced 35.72 15.96 29 6970 14847 29552681
Myoclonic epilepsy 35.66 15.96 12 6987 963 29566565
Chorioretinopathy 34.90 15.96 13 6986 1403 29566125
Glaucoma 34.80 15.96 20 6979 5837 29561691
Eye infection toxoplasmal 33.01 15.96 8 6991 194 29567334
Intraocular pressure increased 32.93 15.96 18 6981 4771 29562757
Rhegmatogenous retinal detachment 32.43 15.96 6 6993 36 29567492
Cystoid macular oedema 32.12 15.96 10 6989 626 29566902
Skin exfoliation 30.59 15.96 32 6967 22613 29544915
Off label use 30.47 15.96 146 6853 300654 29266874
Retinal scar 30.31 15.96 8 6991 276 29567252
Chondritis 30.03 15.96 7 6992 143 29567385
Adrenal suppression 29.56 15.96 9 6990 523 29567005
Endophthalmitis 29.16 15.96 14 6985 2834 29564694
Retinal oedema 29.05 15.96 9 6990 554 29566974
Pneumonia lipoid 28.57 15.96 6 6993 74 29567454
Adrenal insufficiency 27.39 15.96 22 6977 11092 29556436
Product use in unapproved indication 27.12 15.96 62 6937 86813 29480715
Dry skin 24.69 15.96 29 6970 23278 29544250
Shared psychotic disorder 23.17 15.96 4 6995 15 29567513
Skin fissures 22.26 15.96 13 6986 3906 29563622
Injection site plaque 22.05 15.96 3 6996 0 29567528
Eye infection syphilitic 22.05 15.96 3 6996 0 29567528
Application site pruritus 21.72 15.96 9 6990 1288 29566240
Infective scleritis 21.62 15.96 4 6995 24 29567504
Toxicity to various agents 20.08 15.96 8 6991 173653 29393875
Hypothalamic pituitary adrenal axis suppression 19.98 15.96 5 6994 139 29567389
Polypoidal choroidal vasculopathy 19.30 15.96 5 6994 160 29567368
Diarrhoea 19.00 15.96 139 6860 332559 29234969
Oesophageal carcinoma recurrent 18.75 15.96 3 6996 6 29567522
Psoriatic arthropathy 18.49 15.96 20 6979 14671 29552857
Surgery 18.38 15.96 18 6981 11761 29555767
Therapy non-responder 18.29 15.96 29 6970 30882 29536646
Intracranial hypotension 17.90 15.96 5 6994 214 29567314
Cataract 17.59 15.96 24 6975 22354 29545174
Hyperadrenocorticism 17.15 15.96 4 6995 82 29567446
Retinal artery occlusion 16.68 15.96 8 6991 1615 29565913
Blepharospasm 16.59 15.96 7 6992 1048 29566480
Hypotony of eye 16.43 15.96 4 6995 99 29567429

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Psoriasis 387.99 14.06 245 17927 71458 64409102
Adrenal insufficiency 341.12 14.06 153 18019 22334 64458226
Human antichimeric antibody positive 226.32 14.06 57 18115 1359 64479201
Body height below normal 221.65 14.06 59 18113 1759 64478801
Polyarthritis 166.29 14.06 72 18100 9643 64470917
Obesity 149.27 14.06 85 18087 20477 64460083
Joint destruction 145.49 14.06 50 18122 3586 64476974
Bone density decreased 135.97 14.06 63 18109 9889 64470671
Dermatitis atopic 123.48 14.06 45 18127 3831 64476729
Wheelchair user 122.41 14.06 47 18125 4625 64475935
Drug specific antibody 120.89 14.06 38 18134 2057 64478503
Mycotic endophthalmitis 116.91 14.06 21 18151 84 64480476
Product dose omission issue 90.34 14.06 181 17991 194566 64285994
Deposit eye 88.99 14.06 15 18157 37 64480523
Therapy non-responder 80.46 14.06 96 18076 65803 64414757
Gastroenteritis viral 76.69 14.06 55 18117 19674 64460886
Eye infection toxoplasmal 74.83 14.06 19 18153 468 64480092
Steroid withdrawal syndrome 74.06 14.06 20 18152 630 64479930
Antibody test positive 73.17 14.06 27 18145 2380 64478180
Immunodeficiency 72.13 14.06 49 18123 16075 64464485
Product compounding quality issue 69.73 14.06 12 18160 35 64480525
Ocular hypertension 69.14 14.06 22 18150 1239 64479321
Hypothalamic pituitary adrenal axis suppression 68.31 14.06 16 18156 278 64480282
Adrenal suppression 68.03 14.06 22 18150 1305 64479255
Product contamination microbial 68.00 14.06 20 18152 863 64479697
Drug ineffective 66.26 14.06 433 17739 839814 63640746
Chorioretinopathy 64.42 14.06 24 18148 2173 64478387
Perioral dermatitis 64.18 14.06 15 18157 258 64480302
Non-infectious endophthalmitis 57.40 14.06 14 18158 291 64480269
Ankle arthroplasty 54.64 14.06 17 18155 889 64479671
Off label use 53.36 14.06 332 17840 632474 63848086
Transmission of an infectious agent via product 53.13 14.06 12 18160 176 64480384
Red blood cell sedimentation rate increased 52.82 14.06 54 18118 31181 64449379
Rhegmatogenous retinal detachment 50.60 14.06 11 18161 134 64480426
Product use in unapproved indication 49.70 14.06 135 18037 176483 64304077
Septic shock 48.81 14.06 98 18074 105339 64375221
Mobility decreased 46.13 14.06 85 18087 85755 64394805
Injection site atrophy 44.84 14.06 12 18160 365 64480195
Drug ineffective for unapproved indication 44.11 14.06 49 18123 31084 64449476
Toxicity to various agents 43.76 14.06 24 18148 363489 64117071
Diarrhoea 43.26 14.06 349 17823 722355 63758205
Skin atrophy 43.01 14.06 23 18149 4897 64475663
Necrotising scleritis 41.90 14.06 10 18162 189 64480371
Arthritis 41.32 14.06 80 18092 83734 64396826
Eczema 40.78 14.06 46 18126 29674 64450886
Intraocular pressure increased 38.97 14.06 26 18146 8276 64472284
Retinal artery occlusion 38.47 14.06 18 18154 2885 64477675
Shared psychotic disorder 36.91 14.06 7 18165 40 64480520
Completed suicide 36.76 14.06 9 18163 224405 64256155
Synovitis 36.54 14.06 84 18088 99006 64381554
Condition aggravated 36.16 14.06 203 17969 372223 64108337
Cushingoid 36.15 14.06 24 18148 7579 64472981
Hypocalcaemia 35.61 14.06 51 18121 41702 64438858
Visual acuity reduced 32.22 14.06 39 18133 27102 64453458
Bone density increased 32.07 14.06 10 18162 527 64480033
Human anti-human antibody test 30.81 14.06 9 18163 379 64480181
Rapidly progressive osteoarthritis 30.73 14.06 5 18167 9 64480551
Retinal scar 30.63 14.06 9 18163 387 64480173
Endophthalmitis 30.62 14.06 19 18153 5346 64475214
Cystoid macular oedema 29.86 14.06 13 18159 1761 64478799
Nausea 28.97 14.06 343 17829 785457 63695103
Quality of life decreased 28.59 14.06 21 18151 7785 64472775
Loss of personal independence in daily activities 28.46 14.06 63 18109 72391 64408169
Plastic surgery 28.41 14.06 6 18166 63 64480497
Retinal oedema 28.06 14.06 10 18162 798 64479762
Glaucoma 27.16 14.06 28 18144 16320 64464240
Rash 27.07 14.06 221 17951 458328 64022232
Foot operation 26.74 14.06 16 18156 4219 64476341
Cataract 26.57 14.06 50 18122 51212 64429348
General physical health deterioration 25.30 14.06 13 18159 204412 64276148
Impaired quality of life 25.05 14.06 18 18154 6453 64474107
Dystrophic calcification 24.72 14.06 6 18166 122 64480438
Psoriatic arthropathy 24.68 14.06 44 18128 43237 64437323
Staphylococcal infection 24.51 14.06 48 18124 50630 64429930
Pruritus 24.39 14.06 161 18011 312239 64168321
Bursitis infective 24.21 14.06 10 18162 1190 64479370
Short stature 24.17 14.06 7 18165 286 64480274
Chondritis 23.70 14.06 6 18166 146 64480414
Cataract subcapsular 23.49 14.06 9 18163 880 64479680
Pneumonia lipoid 23.03 14.06 6 18166 164 64480396
Intentional product use issue 23.00 14.06 69 18103 95295 64385265
Birdshot chorioretinopathy 22.63 14.06 5 18167 66 64480494
Lipoatrophy 22.46 14.06 8 18164 637 64479923
Red blood cell sedimentation rate abnormal 21.96 14.06 25 18147 16281 64464279
Dry skin 21.82 14.06 46 18126 51115 64429445
Choroiditis 21.73 14.06 9 18163 1078 64479482
Cauda equina syndrome 21.61 14.06 9 18163 1094 64479466
Tractional retinal detachment 21.45 14.06 5 18167 85 64480475
Hypotony of eye 21.13 14.06 6 18166 228 64480332
Necrotising fasciitis 21.04 14.06 15 18157 5311 64475249
Articular calcification 20.92 14.06 5 18167 95 64480465
Bradycardia 20.85 14.06 4 18168 118215 64362345
Joint effusion 20.46 14.06 22 18150 13451 64467109
Infective scleritis 20.27 14.06 4 18168 29 64480531
Dermatitis contact 19.82 14.06 18 18154 8982 64471578
Pyloric abscess 19.45 14.06 3 18169 3 64480557
Eye infection syphilitic 18.98 14.06 3 18169 4 64480556
Tendon rupture 18.90 14.06 19 18153 10748 64469812
Application site pruritus 18.85 14.06 12 18160 3527 64477033
Foot deformity 18.43 14.06 23 18149 16481 64464079
Infusion related reaction 18.16 14.06 12 18160 164455 64316105
Macular fibrosis 18.05 14.06 7 18165 707 64479853
Keratitis fungal 17.87 14.06 5 18167 180 64480380
Skin discolouration 17.79 14.06 34 18138 35221 64445339
Skin exfoliation 17.59 14.06 39 18133 44846 64435714
Lenticular opacities 17.35 14.06 6 18166 438 64480122
Skin odour abnormal 17.09 14.06 9 18163 1858 64478702
Cross sensitivity reaction 16.91 14.06 11 18161 3356 64477204
Extraskeletal ossification 16.89 14.06 4 18168 73 64480487
Arthropathy 16.73 14.06 73 18099 120894 64359666
Injection site plaque 16.64 14.06 4 18168 78 64480482
Type I hypersensitivity 16.31 14.06 11 18161 3563 64476997
Rash pruritic 16.23 14.06 44 18128 57360 64423200
Skin plaque 16.11 14.06 16 18156 8924 64471636
Intentional overdose 15.95 14.06 3 18169 89941 64390619
Pleural effusion 15.73 14.06 74 18098 126485 64354075
Squamous cell carcinoma of skin 15.64 14.06 18 18154 11858 64468702
Dermatitis 15.34 14.06 22 18150 18007 64462553
Infective tenosynovitis 15.28 14.06 5 18167 308 64480252
C-reactive protein increased 15.26 14.06 60 18112 94849 64385711
Hyperadrenocorticism 15.23 14.06 5 18167 311 64480249
Retinal artery embolism 14.72 14.06 4 18168 129 64480431
Parakeratosis 14.66 14.06 5 18167 350 64480210
Uveitis 14.65 14.06 18 18154 12690 64467870
Intracranial hypotension 14.65 14.06 5 18167 351 64480209
Acute kidney injury 14.61 14.06 71 18101 449169 64031391
Extradural abscess 14.60 14.06 7 18165 1184 64479376
Application site pain 14.60 14.06 11 18161 4237 64476323
Cardio-respiratory arrest 14.17 14.06 5 18167 98388 64382172
Drug abuse 14.15 14.06 10 18162 132364 64348196
Drug intolerance 14.11 14.06 96 18076 187896 64292664

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AC01 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Corticosteroids for local oral treatment
ATC C05AA12 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AB09 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, moderately potent (group II)
ATC D07BB03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, moderately potent, combinations with antiseptics
ATC D07CB01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, moderately potent, combinations with antibiotics
ATC D07XB02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, moderately potent, other combinations
ATC H02AB08 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD11 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA06 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S02CA04 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Lichen planus indication 4776004 DOID:9201
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Keloid scar indication 33659008
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Candidiasis of skin indication 49883006
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Necrobiosis lipoidica diabeticorum indication 56391002
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Alopecia areata indication 68225006 DOID:986
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Sympathetic uveitis indication 75315001 DOID:12029
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Subacute bursitis indication 109298000
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Asthma management indication 406162001
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Giant cell arteritis indication 414341000 DOID:13375
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Post traumatic osteoarthritis indication 699262001
Synovitis due to Osteoarthritis indication
Erythroblastic Anemia indication
Gingival Disorders indication
Vitrectomy Adjunct to Enhance Visualization indication
Allergic Rhinitis Prevention indication
Transfusion Reaction Urticaria indication
Systemic Dermatomyositis indication
Chronic Non-Allergic Rhinitis indication
Severe Ocular Inflammation indication
Cystic Aponeurosis Tumor indication
Diagnostic Test for Cushing's Syndrome indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Severe chronic obstructive pulmonary disease off-label use 313299006
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Neonatal Bronchopulmonary Dysplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Fungal infection of eye contraindication 31194008
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Herpes zoster keratoconjunctivitis contraindication 42448002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Candidiasis of mouth contraindication 79740000 DOID:14262
Perforation of nasal septum contraindication 80142000
Hyperglycemia contraindication 80394007 DOID:4195
Open-angle glaucoma contraindication 84494001 DOID:1067
Bacterial infectious disease contraindication 87628006
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Oral infection contraindication 275393007
Varicella-zoster virus infection contraindication 309465005
Viral eye infection contraindication 312132001
Osteopenia contraindication 312894000
Skin irritation contraindication 367466007
Herpes zoster keratitis contraindication 397573005
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Periodontal Infections contraindication
Nasal Candidiasis contraindication
Untreated Fungal Infection contraindication
Oropharyngeal Candidiasis contraindication
Arginosuccinate Lyase Deficiency contraindication
Ornithine Carbamyltransferase Deficiency contraindication
Nasal Trauma contraindication
Uncontrolled Bacterial Infections contraindication
Nasal Septal Ulcers contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.2 acidic
pKa2 11.84 acidic
pKa3 13.18 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 7.59 DRUG MATRIX CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Progesterone receptor Nuclear hormone receptor WOMBAT-PK

External reference:

IDSource
4017599 VUID
N0000145980 NUI
D00385 KEGG_DRUG
4017599 VANDF
C0040864 UMLSCUI
CHEBI:9667 CHEBI
CHEMBL1451 ChEMBL_ID
D014221 MESH_DESCRIPTOR_UI
DB00620 DRUGBANK_ID
31307 PUBCHEM_CID
2870 IUPHAR_LIGAND_ID
755 INN_ID
1ZK20VI6TY UNII
10759 RXNORM
4582 MMSL
5613 MMSL
d00620 MMSL
002188 NDDF
116594009 SNOMEDCT_US
6028009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRIAMCINOLONE ACETONIDE Human Prescription Drug Label 1 67877-470 CREAM 0.25 mg TOPICAL ANDA 17 sections
TRIAMCINOLONE ACETONIDE Human Prescription Drug Label 1 67877-471 CREAM 1 mg TOPICAL ANDA 17 sections
TRIAMCINOLONE ACETONIDE Human Prescription Drug Label 1 67877-472 CREAM 5 mg TOPICAL ANDA 17 sections
Naltrexone HUMAN PRESCRIPTION DRUG LABEL 2 69364-3143 IMPLANT 6.50 mg SUBCUTANEOUS Unapproved drug other 25 sections