tretoquinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quinoline derivatives	2723	30418-38-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tretoquinol
(S)-Trimetoquinol
L-Tretoquinol

An adrenergic beta-agonist used as a bronchodilator agent in asthma therapy.

Molecular weight: 345.40
Formula: C19H23NO5
CLOGP: 1.67
LIPINSKI: 0
HAC: 6
HDO: 3
TPSA: 80.18
ALOGS: -3.54
ROTB: 5

Drug dosage:

Dose	Unit	Route
9	mg	O
0.20	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R03AC09	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists
ATC	R03CC09	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS FOR SYSTEMIC USE Selective beta-2-adrenoreceptor agonists
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000318	Adrenergic beta-Agonists
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D013566	Sympathomimetics

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.36	acidic
pKa2	12.89	acidic
pKa3	8.04	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	8.27		PDSP
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	7.67		PDSP
Thromboxane A2 receptor	GPCR	P21731	TA2R_HUMAN		IC50	6.35		CHEMBL
Adrenergic receptor beta	GPCR	P07550 P08588 P13945	ADRB2_HUMAN ADRB1_HUMAN ADRB3_HUMAN		EC50	7.51		CHEMBL
Beta-2 adrenergic receptor	GPCR		ADRB2_CAVPO		EC50	7.58		CHEMBL
Beta-1 adrenergic receptor	GPCR		B0FL73_CAVPO		EC50	6.76		CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		Ki	5.30		CHEMBL
Adrenergic receptor alpha	GPCR		ADA1B_RAT ADA2B_RAT ADA2C_RAT ADA2A_RAT ADA1D_RAT ADA1A_RAT		Ki	5		CHEMBL
Adrenergic receptor beta	GPCR		ADRB2_RAT ADRB1_RAT ADRB3_RAT		Ki	7		CHEMBL

External reference:

ID	Source
D08629	KEGG_DRUG
C0040846	UMLSCUI
CHEBI:135461	CHEBI
CHEMBL299175	ChEMBL_ID
DB13692	DRUGBANK_ID
D014213	MESH_DESCRIPTOR_UI
656634	PUBCHEM_CID
2648	INN_ID
JIO3275WGI	UNII
008209	NDDF
708662002	SNOMEDCT_US

Pharmaceutical products:

None