tretinoin tocoferil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2721 40516-48-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tocoretinate
  • olcenon
  • tretinoin tocoferil
a hybrid compound composed of alpha-tocopherol esterified with retinoic acid; RN refers to (2R*(4R*,8R*)-(+-))-isomer
  • Molecular weight: 713.14
  • Formula: C49H76O3
  • CLOGP: 12
  • LIPINSKI: 2
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -7.53
  • ROTB: 19
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0018962 Retinoids
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:50176 keratolytic drugs
CHEBI has role CHEBI:62488 signal molecules
CHEBI has role CHEBI:63794 retinoid X receptor agonists
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:67198 retinoic acid receptor agonists
CHEBI has role CHEBI:67199 activator protein-1 antagonists
CHEBI has role CHEBI:77746 Homo sapiens metabolite
FDA EPC N0000175607 Retinoid
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D007641 Keratolytic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01516 KEGG_DRUG
4018550 VANDF
CHEBI:32240 CHEBI
CHEBI:15367 CHEBI
CHEMBL2218871 ChEMBL_ID
CHEMBL262520 ChEMBL_ID
C089853 MESH_SUPPLEMENTAL_RECORD_UI
DB11635 DRUGBANK_ID
10753 RXNORM
46802 MMSL
5610 MMSL
d03863 MMSL
001954 NDDF
009945 NDDF
387305002 SNOMEDCT_US
54972005 SNOMEDCT_US
C0289588 UMLSCUI
C0606070 UMLSCUI
C0040845 UMLSCUI
DB00755 DRUGBANK_ID
6847 INN_ID
5282180 PUBCHEM_CID
2875 INN_ID
D014212 MESH_DESCRIPTOR_UI
444795 PUBCHEM_CID
CTD060B1SS UNII

Pharmaceutical products:

None