azelnidipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	272	123524-52-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

azelnidipine
calblock
CS-905

Molecular weight: 582.66
Formula: C33H34N4O6
CLOGP: 6.96
LIPINSKI: 2
HAC: 10
HDO: 2
TPSA: 137.03
ALOGS: -5.85
ROTB: 11

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	49.33	30.86	22	694	44341	34911874
Cerebral infarction	38.30	30.86	16	700	27439	34928776
Renal impairment	33.69	30.86	22	694	94491	34861724

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral infarction	65.02	29.09	27	1601	45649	79697111
Hepatic function abnormal	64.80	29.09	31	1597	73076	79669684
Renal impairment	42.65	29.09	31	1597	157752	79585008
Cardiac failure	36.43	29.09	28	1600	154814	79587946
Platelet count decreased	32.81	29.09	29	1599	194635	79548125

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.74	Basic
pKa2	1.78	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Voltage-gated L-type calcium channel	Ion channel	Q01668 Q13936	CAC1D_HUMAN CAC1C_HUMAN	BLOCKER				DRUG LABEL	KEGG DRUG

External reference:

ID	Source
D01145	KEGG_DRUG
C0753287	UMLSCUI
CHEBI:31247	CHEBI
CHEMBL1275868	ChEMBL_ID
DB09230	DRUGBANK_ID
C061679	MESH_SUPPLEMENTAL_RECORD_UI
7109	INN_ID
PV23P19YUG	UNII
65948	PUBCHEM_CID

Pharmaceutical products:

None