torsemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, furosemide derivatives	2708	56211-40-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: torasemide torsemide toradiur	A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION. Molecular weight: 348.42 Formula: C16H20N4O3S CLOGP: 3.21 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 100.19 ALOGS: -3.77 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

torasemide
torsemide
toradiur

A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.

Molecular weight: 348.42
Formula: C16H20N4O3S
CLOGP: 3.21
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 100.19
ALOGS: -3.77
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
15	mg	O
15	mg	P

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	91 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
MRTD (Maximum Recommended Therapeutic Daily Dose)	9.56 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
t_half (Half-life)	5.10 hours	Lombardo F, Berellini G, Obach RS
EoM (Fraction excreted unchanged in urine)	20 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)	0.53 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	0.21 L/kg	Lombardo F, Berellini G, Obach RS
S (Water solubility)	0.16 mg/mL	Benet LZ, Broccatelli F, Oprea TI
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS

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Approvals:

Date	Agency	Company	Orphan
Aug. 23, 1993	FDA	MEDA PHARMS

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1792.17	12.46	1599	68467	199803	63219153
Product prescribing error	1008.62	12.46	519	69547	25770	63393186
Product monitoring error	825.39	12.46	273	69793	4243	63414713
Haematochezia	656.26	12.46	513	69553	53031	63365925
Cardiac failure	608.80	12.46	613	69453	88529	63330427
Drug ineffective	548.71	12.46	236	69830	1044529	62374427
Renal impairment	474.63	12.46	535	69531	87820	63331136
Dyspnoea	451.15	12.46	1673	68393	659640	62759316
Oedema peripheral	434.55	12.46	762	69304	188749	63230207
Labelled drug-drug interaction medication error	430.11	12.46	235	69831	13164	63405792

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	1672.12	12.06	1636	67941	126633	34760721
Oedema peripheral	670.41	12.06	996	68581	118816	34768538
Cardiac failure	659.15	12.06	858	68719	90390	34796964
Product monitoring error	479.91	12.06	214	69363	4167	34883187
Product prescribing error	450.75	12.06	370	69207	22557	34864797
Haematochezia	428.44	12.06	495	69082	46039	34841315
Dyspnoea	423.10	12.06	1670	67907	375112	34512242
Drug ineffective	326.70	12.06	260	69317	456491	34430863
Systemic infection	321.57	12.06	172	69405	5040	34882314
Anaemia	279.24	12.06	1057	68520	232278	34655076

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
General physical health deterioration	3457.45	11.34	3102	122828	272136	79346322
Product prescribing error	1426.62	11.34	886	125044	43927	79574531
Product monitoring error	1247.10	11.34	485	125445	8421	79610037
Cardiac failure	1114.31	11.34	1296	124634	153546	79464912
Haematochezia	1101.11	11.34	991	124939	86654	79531804
Oedema peripheral	1069.50	11.34	1629	124301	250659	79367799
Dyspnoea	848.47	11.34	3116	122814	853909	78764549
Systemic infection	727.97	11.34	340	125590	9412	79609046
Drug ineffective	723.23	11.34	407	125523	1080506	78537952
Anaemia	701.25	11.34	1903	124027	443112	79175346

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C03CA04	CARDIOVASCULAR SYSTEM DIURETICS HIGH-CEILING DIURETICS Sulfonamides, plain
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:77608	loop diuretics
FDA EPC	N0000175590	Loop Diuretic
FDA PE	N0000175366	Increased Diuresis at Loop of Henle
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004232	Diuretics
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D045283	Natriuretic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Decompensated cardiac failure	indication	195111005
Edema	indication	267038008
Pulmonary Edema due to Chronic Heart Failure	indication
Peripheral Edema due to Chronic Heart Failure	indication
Renal Disease with Edema	indication
Edema due to Hepatic Cirrhosis	indication
Metabolic alkalosis	contraindication	1388004
Anuria	contraindication	2472002	DOID:2983
Cirrhosis of liver	contraindication	19943007	DOID:5082

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.25	acidic
pKa2	6.98	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Solute carrier family 12 member 1	Transporter	Q13621	S12A1_HUMAN	INHIBITOR	IC50	6.40		WOMBAT-PK	CHEMBL

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External reference:

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ID	Source
004414	NDDF
108476002	SNOMEDCT_US
318034005	SNOMEDCT_US
38413	RXNORM
3938	INN_ID
4020851	VUID
4020851	VANDF
41781	PUBCHEM_CID
43738	MMSL
5604	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0077	TABLET	20 mg	ORAL	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0517-0770	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0517-0771	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	24 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-5575	TABLET	20 mg	ORAL	ANDA	23 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7997	TABLET	20 mg	ORAL	ANDA	23 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7997	TABLET	20 mg	ORAL	ANDA	23 sections
Torsemide	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7283	TABLET	20 mg	ORAL	ANDA	24 sections
Torsemide	Human Prescription Drug Label	1	23155-871	TABLET	5 mg	ORAL	ANDA	25 sections
Torsemide	Human Prescription Drug Label	1	23155-872	TABLET	10 mg	ORAL	ANDA	25 sections
Torsemide	Human Prescription Drug Label	1	23155-873	TABLET	20 mg	ORAL	ANDA	25 sections

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