Stem definition | Drug id | CAS RN |
---|---|---|
2706 | 97240-79-4 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 9.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 70 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.65 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.80 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.27 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.72 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 34.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 24, 1996 | FDA | JANSSEN PHARMS | |
July 1, 2007 | PMDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angle closure glaucoma | 1193.04 | 10.27 | 340 | 108134 | 1879 | 63378669 |
Seizure | 1171.40 | 10.27 | 1282 | 107192 | 131352 | 63249196 |
Migraine | 639.36 | 10.27 | 834 | 107640 | 102512 | 63278036 |
Product substitution issue | 472.99 | 10.27 | 311 | 108163 | 15685 | 63364863 |
Myopia | 452.58 | 10.27 | 151 | 108323 | 1504 | 63379044 |
Drug ineffective for unapproved indication | 424 | 10.27 | 397 | 108077 | 33666 | 63346882 |
Completed suicide | 420.12 | 10.27 | 830 | 107644 | 144843 | 63235705 |
Choroidal effusion | 396.53 | 10.27 | 103 | 108371 | 373 | 63380175 |
Multiple-drug resistance | 353.57 | 10.27 | 174 | 108300 | 4996 | 63375552 |
Intentional self-injury | 326.63 | 10.27 | 303 | 108171 | 25384 | 63355164 |
Visual perseveration | 321.42 | 10.27 | 62 | 108412 | 13 | 63380535 |
Renal tubular acidosis | 311.54 | 10.27 | 115 | 108359 | 1577 | 63378971 |
Epilepsy | 311.26 | 10.27 | 302 | 108172 | 26763 | 63353785 |
Status epilepticus | 293.03 | 10.27 | 228 | 108246 | 15005 | 63365543 |
Suicidal ideation | 290.74 | 10.27 | 440 | 108034 | 61981 | 63318567 |
Pemphigus | 269.87 | 10.27 | 10 | 108464 | 183716 | 63196832 |
Joint swelling | 268.54 | 10.27 | 112 | 108362 | 327554 | 63052994 |
Intentional overdose | 252.64 | 10.27 | 454 | 108020 | 73698 | 63306850 |
Synovitis | 236.26 | 10.27 | 23 | 108451 | 186895 | 63193653 |
Depression | 222.73 | 10.27 | 790 | 107684 | 195702 | 63184846 |
Abortion spontaneous | 220.19 | 10.27 | 333 | 108141 | 46862 | 63333686 |
Paraesthesia | 217.00 | 10.27 | 675 | 107799 | 156291 | 63224257 |
Hand deformity | 211.39 | 10.27 | 16 | 108458 | 159441 | 63221107 |
Nephrolithiasis | 209.89 | 10.27 | 306 | 108168 | 41678 | 63338870 |
Somnolence | 206.43 | 10.27 | 723 | 107751 | 177962 | 63202586 |
Generalised tonic-clonic seizure | 201.02 | 10.27 | 248 | 108226 | 28768 | 63351780 |
Metabolic acidosis | 200.40 | 10.27 | 311 | 108163 | 44758 | 63335790 |
Glossodynia | 197.30 | 10.27 | 34 | 108440 | 178842 | 63201706 |
Arthropathy | 192.65 | 10.27 | 80 | 108394 | 234712 | 63145836 |
Memory impairment | 190.53 | 10.27 | 496 | 107978 | 103762 | 63276786 |
Toxicity to various agents | 183.35 | 10.27 | 872 | 107602 | 246378 | 63134170 |
Wound | 180.12 | 10.27 | 31 | 108443 | 163232 | 63217316 |
Infusion related reaction | 176.57 | 10.27 | 100 | 108374 | 245421 | 63135127 |
Overdose | 171.27 | 10.27 | 508 | 107966 | 114570 | 63265978 |
Choroidal detachment | 164.00 | 10.27 | 44 | 108430 | 186 | 63380362 |
Petit mal epilepsy | 163.90 | 10.27 | 94 | 108380 | 3700 | 63376848 |
Abdominal discomfort | 160.71 | 10.27 | 187 | 108287 | 320698 | 63059850 |
Anti-cyclic citrullinated peptide antibody positive | 158.83 | 10.27 | 10 | 108464 | 116202 | 63264346 |
Pericarditis | 156.61 | 10.27 | 20 | 108454 | 131559 | 63248989 |
Drug ineffective | 150.92 | 10.27 | 2560 | 105914 | 1042205 | 62338343 |
Contraindicated product administered | 150.33 | 10.27 | 93 | 108381 | 217555 | 63162993 |
Blepharospasm | 149.64 | 10.27 | 105 | 108369 | 5891 | 63374657 |
Hyperammonaemic encephalopathy | 149.00 | 10.27 | 76 | 108398 | 2358 | 63378190 |
Rheumatoid arthritis | 147.47 | 10.27 | 130 | 108344 | 253689 | 63126859 |
Irritability | 146.92 | 10.27 | 223 | 108251 | 31471 | 63349077 |
Disturbance in attention | 145.88 | 10.27 | 246 | 108228 | 37943 | 63342605 |
Acute myopia | 136.57 | 10.27 | 33 | 108441 | 81 | 63380467 |
Swelling | 134.09 | 10.27 | 164 | 108310 | 275214 | 63105334 |
Systemic lupus erythematosus | 133.88 | 10.27 | 97 | 108377 | 208821 | 63171727 |
Exposure during pregnancy | 133.43 | 10.27 | 573 | 107901 | 154974 | 63225574 |
Aggression | 133.32 | 10.27 | 182 | 108292 | 23316 | 63357232 |
Psychotic disorder | 130.81 | 10.27 | 189 | 108285 | 25523 | 63355025 |
Headache | 130.21 | 10.27 | 1651 | 106823 | 631590 | 62748958 |
Rheumatoid factor positive | 129.69 | 10.27 | 3 | 108471 | 84403 | 63296145 |
Anaemia | 126.47 | 10.27 | 191 | 108283 | 293239 | 63087309 |
Cognitive disorder | 124.75 | 10.27 | 287 | 108187 | 55528 | 63325020 |
Myokymia | 123.60 | 10.27 | 23 | 108451 | 0 | 63380548 |
Febrile neutropenia | 123.17 | 10.27 | 26 | 108448 | 118423 | 63262125 |
Myoclonic epilepsy | 122.41 | 10.27 | 54 | 108420 | 1200 | 63379348 |
Acidosis hyperchloraemic | 120.63 | 10.27 | 40 | 108434 | 390 | 63380158 |
Medication overuse headache | 118.86 | 10.27 | 47 | 108427 | 785 | 63379763 |
Helicobacter infection | 115.65 | 10.27 | 12 | 108462 | 92773 | 63287775 |
Arthralgia | 114.90 | 10.27 | 542 | 107932 | 569168 | 62811380 |
Duodenal ulcer perforation | 114.83 | 10.27 | 9 | 108465 | 87200 | 63293348 |
Tremor | 114.82 | 10.27 | 489 | 107985 | 131750 | 63248798 |
Product use in unapproved indication | 114.53 | 10.27 | 606 | 107868 | 178474 | 63202074 |
Flat anterior chamber of eye | 112.52 | 10.27 | 25 | 108449 | 35 | 63380513 |
Lower respiratory tract infection | 106.97 | 10.27 | 46 | 108428 | 132261 | 63248287 |
Suicide attempt | 106.32 | 10.27 | 285 | 108189 | 60633 | 63319915 |
Peripheral swelling | 105.29 | 10.27 | 183 | 108291 | 265759 | 63114789 |
Drug interaction | 102.85 | 10.27 | 707 | 107767 | 228424 | 63152124 |
Ciliary body disorder | 99.39 | 10.27 | 20 | 108454 | 10 | 63380538 |
Focal dyscognitive seizures | 99.22 | 10.27 | 62 | 108412 | 2859 | 63377689 |
Drug resistance | 98.78 | 10.27 | 156 | 108318 | 22777 | 63357771 |
Aphasia | 98.51 | 10.27 | 191 | 108283 | 32809 | 63347739 |
Discomfort | 96.82 | 10.27 | 86 | 108388 | 167288 | 63213260 |
Pneumonia | 96.49 | 10.27 | 427 | 108047 | 456340 | 62924208 |
Intraocular pressure increased | 95.79 | 10.27 | 81 | 108393 | 5997 | 63374551 |
Abnormal behaviour | 95.42 | 10.27 | 148 | 108326 | 21278 | 63359270 |
Infection | 95.05 | 10.27 | 153 | 108321 | 229020 | 63151528 |
Malignant neoplasm progression | 94.11 | 10.27 | 14 | 108460 | 82107 | 63298441 |
Anxiety | 91.04 | 10.27 | 660 | 107814 | 216881 | 63163667 |
Acute kidney injury | 90.60 | 10.27 | 197 | 108277 | 263218 | 63117330 |
Rash | 89.75 | 10.27 | 576 | 107898 | 560295 | 62820253 |
General physical health deterioration | 89.74 | 10.27 | 128 | 108346 | 201274 | 63179274 |
Vision blurred | 88.50 | 10.27 | 351 | 108123 | 91573 | 63288975 |
Partial seizures | 88.28 | 10.27 | 76 | 108398 | 5766 | 63374782 |
Anorexia nervosa | 87.43 | 10.27 | 28 | 108446 | 242 | 63380306 |
Blindness | 87.17 | 10.27 | 143 | 108331 | 21556 | 63358992 |
Stomatitis | 86.77 | 10.27 | 66 | 108408 | 138659 | 63241889 |
Paradoxical drug reaction | 86.09 | 10.27 | 65 | 108409 | 4087 | 63376461 |
Impaired healing | 85.55 | 10.27 | 34 | 108440 | 102508 | 63278040 |
Folliculitis | 85.34 | 10.27 | 10 | 108464 | 70307 | 63310241 |
Muscle injury | 85.31 | 10.27 | 7 | 108467 | 65338 | 63315210 |
Multiple sclerosis relapse | 83.78 | 10.27 | 226 | 108248 | 48252 | 63332296 |
Pyrexia | 83.21 | 10.27 | 468 | 108006 | 470010 | 62910538 |
Blister | 80.89 | 10.27 | 62 | 108412 | 129752 | 63250796 |
Hepatic enzyme increased | 80.25 | 10.27 | 139 | 108335 | 202189 | 63178359 |
Cerebral venous thrombosis | 78.05 | 10.27 | 47 | 108427 | 2027 | 63378521 |
Nasopharyngitis | 76.46 | 10.27 | 204 | 108270 | 254053 | 63126495 |
Sleep disorder due to general medical condition, insomnia type | 76.07 | 10.27 | 3 | 108471 | 52214 | 63328334 |
Disease progression | 74.75 | 10.27 | 60 | 108414 | 122698 | 63257850 |
Hypoaesthesia | 74.55 | 10.27 | 518 | 107956 | 167875 | 63212673 |
Diplopia | 74.09 | 10.27 | 140 | 108334 | 23588 | 63356960 |
Multiple sclerosis | 73.89 | 10.27 | 142 | 108332 | 24230 | 63356318 |
Off label use | 73.81 | 10.27 | 1586 | 106888 | 672876 | 62707672 |
Mitochondrial DNA mutation | 71.54 | 10.27 | 27 | 108447 | 395 | 63380153 |
Neovascularisation | 70.81 | 10.27 | 36 | 108438 | 1109 | 63379439 |
Weight decreased | 70.53 | 10.27 | 753 | 107721 | 276045 | 63104503 |
Therapeutic response unexpected | 69.19 | 10.27 | 119 | 108355 | 18640 | 63361908 |
Atrial fibrillation | 68.56 | 10.27 | 59 | 108415 | 116577 | 63263971 |
Dyspnoea | 67.55 | 10.27 | 764 | 107710 | 660549 | 62719999 |
Propofol infusion syndrome | 66.96 | 10.27 | 33 | 108441 | 950 | 63379598 |
Photophobia | 66.53 | 10.27 | 113 | 108361 | 17522 | 63363026 |
Bradyphrenia | 65.83 | 10.27 | 70 | 108404 | 6910 | 63373638 |
Hyperammonaemia | 65.10 | 10.27 | 61 | 108413 | 5171 | 63375377 |
Sluggishness | 64.73 | 10.27 | 61 | 108413 | 5208 | 63375340 |
Corneal oedema | 64.51 | 10.27 | 37 | 108437 | 1456 | 63379092 |
Maculopathy | 64.47 | 10.27 | 43 | 108431 | 2219 | 63378329 |
Pleural effusion | 64.06 | 10.27 | 40 | 108434 | 93170 | 63287378 |
Speech disorder | 63.87 | 10.27 | 183 | 108291 | 40446 | 63340102 |
Withdrawal syndrome | 63.70 | 10.27 | 119 | 108355 | 19878 | 63360670 |
Bipolar disorder | 63.29 | 10.27 | 73 | 108401 | 7887 | 63372661 |
Diarrhoea | 63.07 | 10.27 | 853 | 107621 | 714513 | 62666035 |
Crying | 62.35 | 10.27 | 129 | 108345 | 23214 | 63357334 |
Pancytopenia | 62.05 | 10.27 | 45 | 108429 | 96888 | 63283660 |
Coma blister | 61.86 | 10.27 | 19 | 108455 | 141 | 63380407 |
Cardiac failure | 61.61 | 10.27 | 38 | 108436 | 89104 | 63291444 |
Drug abuse | 61.22 | 10.27 | 266 | 108208 | 72252 | 63308296 |
Neutropenia | 60.86 | 10.27 | 130 | 108344 | 174875 | 63205673 |
Infantile spasms | 60.31 | 10.27 | 20 | 108454 | 195 | 63380353 |
Musculoskeletal stiffness | 60.24 | 10.27 | 142 | 108332 | 184476 | 63196072 |
Alopecia | 59.46 | 10.27 | 336 | 108138 | 337200 | 63043348 |
Hypocitraturia | 59.11 | 10.27 | 11 | 108463 | 0 | 63380548 |
Mucosal inflammation | 58.65 | 10.27 | 6 | 108468 | 46922 | 63333626 |
Anhidrosis | 58.59 | 10.27 | 17 | 108457 | 101 | 63380447 |
Aura | 58.50 | 10.27 | 31 | 108443 | 1042 | 63379506 |
Agitation | 58.16 | 10.27 | 229 | 108245 | 59528 | 63321020 |
Drug withdrawal convulsions | 58.08 | 10.27 | 34 | 108440 | 1391 | 63379157 |
Hypersensitivity | 57.90 | 10.27 | 280 | 108194 | 292405 | 63088143 |
Cardiac failure congestive | 57.76 | 10.27 | 44 | 108430 | 92389 | 63288159 |
Haemoglobin decreased | 57.62 | 10.27 | 100 | 108374 | 145385 | 63235163 |
Dysarthria | 57.36 | 10.27 | 182 | 108292 | 42529 | 63338019 |
Amnesia | 57.35 | 10.27 | 217 | 108257 | 55368 | 63325180 |
Hallucination, auditory | 56.28 | 10.27 | 88 | 108386 | 12736 | 63367812 |
Dizziness | 55.91 | 10.27 | 1038 | 107436 | 428887 | 62951661 |
Mania | 55.87 | 10.27 | 86 | 108388 | 12281 | 63368267 |
Necrotising colitis | 55.76 | 10.27 | 25 | 108449 | 578 | 63379970 |
Visual field defect | 55.26 | 10.27 | 62 | 108412 | 6499 | 63374049 |
Amenorrhoea | 55.04 | 10.27 | 76 | 108398 | 9838 | 63370710 |
Sedation | 54.54 | 10.27 | 168 | 108306 | 38641 | 63341907 |
Blood prolactin increased | 53.80 | 10.27 | 46 | 108428 | 3457 | 63377091 |
Alexia | 51.12 | 10.27 | 10 | 108464 | 3 | 63380545 |
Fanconi syndrome | 50.98 | 10.27 | 31 | 108443 | 1361 | 63379187 |
Visual snow syndrome | 50.95 | 10.27 | 13 | 108461 | 43 | 63380505 |
Eye pain | 50.82 | 10.27 | 150 | 108324 | 33704 | 63346844 |
Visual acuity reduced | 50.71 | 10.27 | 114 | 108360 | 21712 | 63358836 |
Product physical issue | 50.65 | 10.27 | 52 | 108422 | 4928 | 63375620 |
Heat stroke | 50.52 | 10.27 | 26 | 108448 | 822 | 63379726 |
Hip arthroplasty | 50.46 | 10.27 | 10 | 108464 | 47636 | 63332912 |
Hyponatraemia | 49.92 | 10.27 | 71 | 108403 | 111829 | 63268719 |
Self-induced vomiting | 49.79 | 10.27 | 12 | 108462 | 29 | 63380519 |
Ill-defined disorder | 49.71 | 10.27 | 40 | 108434 | 81715 | 63298833 |
Taste disorder | 49.51 | 10.27 | 86 | 108388 | 13576 | 63366972 |
Thrombocytopenia | 49.51 | 10.27 | 116 | 108358 | 151041 | 63229507 |
Feeling abnormal | 48.74 | 10.27 | 426 | 108048 | 147966 | 63232582 |
Knee arthroplasty | 48.55 | 10.27 | 16 | 108458 | 54190 | 63326358 |
Benign familial pemphigus | 48.37 | 10.27 | 9 | 108465 | 0 | 63380548 |
Slow speech | 48.30 | 10.27 | 31 | 108443 | 1498 | 63379050 |
CSF oligoclonal band present | 48.21 | 10.27 | 20 | 108454 | 380 | 63380168 |
Pruritus | 48.08 | 10.27 | 391 | 108083 | 361062 | 63019486 |
Suicidal behaviour | 47.51 | 10.27 | 38 | 108436 | 2601 | 63377947 |
Muscle twitching | 47.12 | 10.27 | 104 | 108370 | 19564 | 63360984 |
Therapeutic product effect decreased | 46.73 | 10.27 | 171 | 108303 | 193016 | 63187532 |
Blood creatinine increased | 46.28 | 10.27 | 49 | 108425 | 87795 | 63292753 |
Mood altered | 46.04 | 10.27 | 87 | 108387 | 14656 | 63365892 |
Mood swings | 45.43 | 10.27 | 98 | 108376 | 18150 | 63362398 |
Interstitial lung disease | 44.74 | 10.27 | 25 | 108449 | 61883 | 63318665 |
Cough | 44.48 | 10.27 | 305 | 108169 | 292438 | 63088110 |
C-reactive protein abnormal | 44.20 | 10.27 | 12 | 108462 | 46084 | 63334464 |
Mental disorder | 43.94 | 10.27 | 120 | 108354 | 25799 | 63354749 |
Change in seizure presentation | 43.84 | 10.27 | 19 | 108455 | 404 | 63380144 |
Salivary gland calculus | 43.78 | 10.27 | 15 | 108459 | 163 | 63380385 |
Blindness transient | 43.44 | 10.27 | 42 | 108432 | 3702 | 63376846 |
Vertigo | 43.36 | 10.27 | 210 | 108264 | 59677 | 63320871 |
Respiratory arrest | 42.82 | 10.27 | 138 | 108336 | 32507 | 63348041 |
Tonic convulsion | 42.72 | 10.27 | 27 | 108447 | 1270 | 63379278 |
Ammonia increased | 42.68 | 10.27 | 46 | 108428 | 4610 | 63375938 |
Somnambulism | 42.67 | 10.27 | 50 | 108424 | 5493 | 63375055 |
Iridocyclitis | 42.63 | 10.27 | 35 | 108439 | 2487 | 63378061 |
Sepsis | 42.20 | 10.27 | 128 | 108346 | 152995 | 63227553 |
Migraine with aura | 42.12 | 10.27 | 36 | 108438 | 2704 | 63377844 |
Oligomenorrhoea | 41.96 | 10.27 | 23 | 108451 | 828 | 63379720 |
Coma | 41.89 | 10.27 | 219 | 108255 | 64145 | 63316403 |
Bulimia nervosa | 41.76 | 10.27 | 19 | 108455 | 455 | 63380093 |
Iris adhesions | 41.42 | 10.27 | 17 | 108457 | 314 | 63380234 |
Bezoar | 41.08 | 10.27 | 28 | 108446 | 1498 | 63379050 |
Major depression | 40.86 | 10.27 | 59 | 108415 | 7959 | 63372589 |
Intentional product misuse | 40.84 | 10.27 | 209 | 108265 | 60708 | 63319840 |
Pulmonary fibrosis | 40.83 | 10.27 | 9 | 108465 | 39800 | 63340748 |
Renal impairment | 40.47 | 10.27 | 55 | 108419 | 88300 | 63292248 |
Mental impairment | 39.92 | 10.27 | 80 | 108394 | 14071 | 63366477 |
Blood bicarbonate decreased | 39.92 | 10.27 | 36 | 108438 | 2905 | 63377643 |
Anger | 39.52 | 10.27 | 74 | 108400 | 12382 | 63368166 |
Nephrocalcinosis | 39.46 | 10.27 | 24 | 108450 | 1054 | 63379494 |
Libido increased | 39.38 | 10.27 | 26 | 108448 | 1319 | 63379229 |
Red blood cell sedimentation rate increased | 39.36 | 10.27 | 13 | 108461 | 43969 | 63336579 |
Atonic seizures | 39.25 | 10.27 | 20 | 108454 | 619 | 63379929 |
Visual impairment | 39.25 | 10.27 | 263 | 108211 | 84183 | 63296365 |
Paranoia | 39.08 | 10.27 | 71 | 108403 | 11608 | 63368940 |
Gene mutation | 38.88 | 10.27 | 28 | 108446 | 1637 | 63378911 |
Anticonvulsant drug level decreased | 38.60 | 10.27 | 25 | 108449 | 1227 | 63379321 |
C-reactive protein increased | 38.49 | 10.27 | 64 | 108410 | 94643 | 63285905 |
Gastrointestinal disorder | 38.13 | 10.27 | 107 | 108367 | 131132 | 63249416 |
Blood gases abnormal | 37.82 | 10.27 | 21 | 108453 | 776 | 63379772 |
Gastrointestinal haemorrhage | 37.72 | 10.27 | 50 | 108424 | 81126 | 63299422 |
Blood pressure systolic increased | 37.46 | 10.27 | 17 | 108457 | 47380 | 63333168 |
Mobility decreased | 37.30 | 10.27 | 96 | 108378 | 121063 | 63259485 |
Ataxia | 37.14 | 10.27 | 81 | 108393 | 15114 | 63365434 |
Angiofibroma | 36.94 | 10.27 | 12 | 108462 | 109 | 63380439 |
Pleocytosis | 36.67 | 10.27 | 21 | 108453 | 824 | 63379724 |
Drug withdrawal syndrome | 36.62 | 10.27 | 116 | 108358 | 27078 | 63353470 |
Phonophobia | 36.42 | 10.27 | 16 | 108458 | 352 | 63380196 |
Hostility | 35.95 | 10.27 | 28 | 108446 | 1844 | 63378704 |
Alice in wonderland syndrome | 35.93 | 10.27 | 9 | 108465 | 27 | 63380521 |
Tardive dyskinesia | 35.46 | 10.27 | 57 | 108417 | 8445 | 63372103 |
Simple partial seizures | 35.39 | 10.27 | 18 | 108456 | 555 | 63379993 |
Oedema | 35.20 | 10.27 | 71 | 108403 | 97551 | 63282997 |
Sudden unexplained death in epilepsy | 35.09 | 10.27 | 15 | 108459 | 308 | 63380240 |
Plasma cell myeloma | 35.08 | 10.27 | 9 | 108465 | 35896 | 63344652 |
Electroencephalogram abnormal | 34.94 | 10.27 | 37 | 108437 | 3635 | 63376913 |
Renal failure | 34.86 | 10.27 | 95 | 108379 | 117557 | 63262991 |
Dysphemia | 34.85 | 10.27 | 32 | 108442 | 2643 | 63377905 |
Central nervous system lesion | 34.76 | 10.27 | 64 | 108410 | 10571 | 63369977 |
Partial seizures with secondary generalisation | 34.65 | 10.27 | 16 | 108458 | 397 | 63380151 |
Galactorrhoea | 34.54 | 10.27 | 39 | 108435 | 4116 | 63376432 |
Death | 34.46 | 10.27 | 442 | 108032 | 373939 | 63006609 |
Pre-existing condition improved | 34.01 | 10.27 | 55 | 108419 | 8189 | 63372359 |
Affective disorder | 33.95 | 10.27 | 47 | 108427 | 6099 | 63374449 |
Osteonecrosis of jaw | 33.95 | 10.27 | 9 | 108465 | 35114 | 63345434 |
Myoclonus | 33.69 | 10.27 | 80 | 108394 | 15788 | 63364760 |
Hyperthermia | 33.65 | 10.27 | 58 | 108416 | 9098 | 63371450 |
Cervix neoplasm | 33.62 | 10.27 | 13 | 108461 | 204 | 63380344 |
Hypophosphataemic osteomalacia | 33.44 | 10.27 | 13 | 108461 | 207 | 63380341 |
Serotonin syndrome | 32.98 | 10.27 | 116 | 108358 | 28566 | 63351982 |
Hypomagnesaemia | 32.69 | 10.27 | 5 | 108469 | 28732 | 63351816 |
Lichen planus | 32.49 | 10.27 | 29 | 108445 | 2309 | 63378239 |
Brugada syndrome | 32.45 | 10.27 | 15 | 108459 | 373 | 63380175 |
Hyperkalaemia | 32.35 | 10.27 | 27 | 108447 | 54176 | 63326372 |
Ciliary muscle spasm | 32.24 | 10.27 | 6 | 108468 | 0 | 63380548 |
Cholecystitis chronic | 32.18 | 10.27 | 61 | 108413 | 10300 | 63370248 |
Nystagmus | 32.03 | 10.27 | 46 | 108428 | 6174 | 63374374 |
Thalamic infarction | 31.98 | 10.27 | 16 | 108458 | 476 | 63380072 |
Weight increased | 31.88 | 10.27 | 624 | 107850 | 260168 | 63120380 |
Arthritis | 31.86 | 10.27 | 97 | 108377 | 115824 | 63264724 |
Drug screen positive | 31.78 | 10.27 | 35 | 108439 | 3594 | 63376954 |
Tearfulness | 31.30 | 10.27 | 37 | 108437 | 4102 | 63376446 |
Psychomotor hyperactivity | 30.94 | 10.27 | 61 | 108413 | 10602 | 63369946 |
Status migrainosus | 30.90 | 10.27 | 11 | 108463 | 135 | 63380413 |
Respiratory alkalosis | 30.78 | 10.27 | 30 | 108444 | 2671 | 63377877 |
Neoplasm progression | 30.50 | 10.27 | 12 | 108462 | 36416 | 63344132 |
Skin ulcer | 30.22 | 10.27 | 18 | 108456 | 43027 | 63337521 |
Apathy | 30.11 | 10.27 | 54 | 108420 | 8740 | 63371808 |
Hypersomnia | 30.01 | 10.27 | 83 | 108391 | 17972 | 63362576 |
Dysgeusia | 29.75 | 10.27 | 158 | 108316 | 46552 | 63333996 |
Apnoea | 29.73 | 10.27 | 51 | 108423 | 7971 | 63372577 |
Blood pressure measurement | 29.50 | 10.27 | 13 | 108461 | 288 | 63380260 |
Concussion | 29.43 | 10.27 | 55 | 108419 | 9189 | 63371359 |
Bone marrow failure | 29.28 | 10.27 | 7 | 108467 | 29283 | 63351265 |
Wheezing | 29.22 | 10.27 | 76 | 108398 | 95519 | 63285029 |
Migraine without aura | 29.20 | 10.27 | 14 | 108460 | 379 | 63380169 |
Amino acid level increased | 29.09 | 10.27 | 14 | 108460 | 382 | 63380166 |
Hypertension | 28.64 | 10.27 | 322 | 108152 | 278981 | 63101567 |
Osteoarthritis | 28.24 | 10.27 | 77 | 108397 | 95266 | 63285282 |
Septic shock | 28.04 | 10.27 | 44 | 108430 | 66585 | 63313963 |
Emotional distress | 27.92 | 10.27 | 120 | 108354 | 32429 | 63348119 |
Therapeutic response changed | 27.72 | 10.27 | 19 | 108455 | 1026 | 63379522 |
Road traffic accident | 27.63 | 10.27 | 130 | 108344 | 36502 | 63344046 |
Eye movement disorder | 27.42 | 10.27 | 39 | 108435 | 5189 | 63375359 |
Post-traumatic neck syndrome | 27.39 | 10.27 | 25 | 108449 | 2049 | 63378499 |
Lung disorder | 27.27 | 10.27 | 40 | 108434 | 62221 | 63318327 |
Erythema | 27.22 | 10.27 | 182 | 108292 | 175569 | 63204979 |
Intellectual disability | 27.06 | 10.27 | 19 | 108455 | 1067 | 63379481 |
Pseudomyopia | 26.96 | 10.27 | 8 | 108466 | 52 | 63380496 |
Disorientation | 26.89 | 10.27 | 136 | 108338 | 39316 | 63341232 |
Hyposthenuria | 26.87 | 10.27 | 5 | 108469 | 0 | 63380548 |
Cardiac malposition | 26.70 | 10.27 | 8 | 108466 | 54 | 63380494 |
Intentional product use issue | 26.63 | 10.27 | 120 | 108354 | 127772 | 63252776 |
Angiomyolipoma | 26.42 | 10.27 | 11 | 108463 | 211 | 63380337 |
Panic attack | 26.27 | 10.27 | 91 | 108383 | 22240 | 63358308 |
Granulomatous dermatitis | 26.21 | 10.27 | 10 | 108464 | 151 | 63380397 |
Retinitis pigmentosa | 26.17 | 10.27 | 9 | 108465 | 99 | 63380449 |
Granuloma annulare | 26.11 | 10.27 | 15 | 108459 | 592 | 63379956 |
Extrapyramidal disorder | 26.10 | 10.27 | 65 | 108409 | 13219 | 63367329 |
Soft tissue injury | 26.00 | 10.27 | 22 | 108452 | 1630 | 63378918 |
Vestibular migraine | 25.82 | 10.27 | 11 | 108463 | 224 | 63380324 |
Anoxia | 25.77 | 10.27 | 11 | 108463 | 225 | 63380323 |
Retinogram abnormal | 25.62 | 10.27 | 10 | 108464 | 161 | 63380387 |
Oedema peripheral | 25.61 | 10.27 | 204 | 108270 | 189307 | 63191241 |
Psychogenic seizure | 25.54 | 10.27 | 22 | 108452 | 1670 | 63378878 |
Melaena | 25.43 | 10.27 | 10 | 108464 | 30355 | 63350193 |
Anticonvulsant drug level above therapeutic | 25.19 | 10.27 | 14 | 108460 | 518 | 63380030 |
Persistent left superior vena cava | 25.13 | 10.27 | 7 | 108467 | 35 | 63380513 |
Cardio-respiratory arrest | 25.07 | 10.27 | 182 | 108292 | 59777 | 63320771 |
Nightmare | 25.05 | 10.27 | 81 | 108393 | 19113 | 63361435 |
Heart rate | 24.89 | 10.27 | 8 | 108466 | 70 | 63380478 |
Drug dependence | 24.77 | 10.27 | 95 | 108379 | 24388 | 63356160 |
Borderline personality disorder | 24.53 | 10.27 | 16 | 108458 | 795 | 63379753 |
Lymphangioleiomyomatosis | 24.50 | 10.27 | 10 | 108464 | 182 | 63380366 |
Liver injury | 24.49 | 10.27 | 41 | 108433 | 60479 | 63320069 |
Screaming | 24.41 | 10.27 | 29 | 108445 | 3233 | 63377315 |
Depressed mood | 24.27 | 10.27 | 134 | 108340 | 40057 | 63340491 |
Thyroxine free decreased | 24.17 | 10.27 | 15 | 108459 | 683 | 63379865 |
Conjunctival oedema | 24.09 | 10.27 | 15 | 108459 | 687 | 63379861 |
Lennox-Gastaut syndrome | 24.08 | 10.27 | 11 | 108463 | 266 | 63380282 |
Rectal haemorrhage | 24.02 | 10.27 | 29 | 108445 | 49001 | 63331547 |
Delusion | 23.82 | 10.27 | 59 | 108415 | 11958 | 63368590 |
Sternal fracture | 23.77 | 10.27 | 24 | 108450 | 2230 | 63378318 |
Dehydration | 23.71 | 10.27 | 186 | 108288 | 173168 | 63207380 |
Iris disorder | 23.68 | 10.27 | 8 | 108466 | 83 | 63380465 |
Myocardial oedema | 23.54 | 10.27 | 10 | 108464 | 202 | 63380346 |
Narrow anterior chamber angle | 23.53 | 10.27 | 7 | 108467 | 46 | 63380502 |
Necrotising enterocolitis neonatal | 23.41 | 10.27 | 10 | 108464 | 205 | 63380343 |
Biliary dyskinesia | 23.35 | 10.27 | 26 | 108448 | 2703 | 63377845 |
Product quality issue | 23.31 | 10.27 | 122 | 108352 | 35743 | 63344805 |
Acquired haemophilia | 23.30 | 10.27 | 17 | 108457 | 1014 | 63379534 |
Loss of consciousness | 23.23 | 10.27 | 306 | 108168 | 117815 | 63262733 |
Acute myocardial infarction | 23.17 | 10.27 | 13 | 108461 | 32111 | 63348437 |
Myelosuppression | 23.05 | 10.27 | 6 | 108468 | 23697 | 63356851 |
Thinking abnormal | 22.97 | 10.27 | 54 | 108420 | 10589 | 63369959 |
Papilloedema | 22.95 | 10.27 | 31 | 108443 | 3929 | 63376619 |
Homicidal ideation | 22.91 | 10.27 | 21 | 108453 | 1731 | 63378817 |
Decreased interest | 22.83 | 10.27 | 28 | 108446 | 3226 | 63377322 |
Gastrooesophageal reflux disease | 22.83 | 10.27 | 257 | 108217 | 95382 | 63285166 |
Hypervolaemia | 22.75 | 10.27 | 10 | 108464 | 28403 | 63352145 |
Product administered to patient of inappropriate age | 22.73 | 10.27 | 28 | 108446 | 3240 | 63377308 |
Macular detachment | 22.64 | 10.27 | 8 | 108466 | 96 | 63380452 |
Frontal lobe epilepsy | 22.50 | 10.27 | 5 | 108469 | 7 | 63380541 |
Affect lability | 22.37 | 10.27 | 55 | 108419 | 11096 | 63369452 |
Anomalous pulmonary venous connection | 22.12 | 10.27 | 7 | 108467 | 58 | 63380490 |
Coronary artery disease | 22.09 | 10.27 | 14 | 108460 | 32363 | 63348185 |
Application site discolouration | 21.95 | 10.27 | 15 | 108459 | 806 | 63379742 |
Mydriasis | 21.93 | 10.27 | 57 | 108417 | 11899 | 63368649 |
Convulsive threshold lowered | 21.57 | 10.27 | 11 | 108463 | 341 | 63380207 |
Antipsychotic drug level decreased | 21.54 | 10.27 | 11 | 108463 | 342 | 63380206 |
Snoring | 21.53 | 10.27 | 31 | 108443 | 4171 | 63376377 |
Fatigue | 21.44 | 10.27 | 1271 | 107203 | 886757 | 62493791 |
Malaise | 21.41 | 10.27 | 544 | 107930 | 415410 | 62965138 |
Brain oedema | 21.40 | 10.27 | 63 | 108411 | 14132 | 63366416 |
Cleft lip | 21.26 | 10.27 | 8 | 108466 | 116 | 63380432 |
Hypohidrosis | 21.22 | 10.27 | 7 | 108467 | 67 | 63380481 |
Small for dates baby | 21.19 | 10.27 | 29 | 108445 | 3722 | 63376826 |
Ascites | 21.13 | 10.27 | 23 | 108451 | 40705 | 63339843 |
Hypoxia | 21.11 | 10.27 | 44 | 108430 | 59748 | 63320800 |
Open angle glaucoma | 21.08 | 10.27 | 10 | 108464 | 264 | 63380284 |
Hypopyon | 21.07 | 10.27 | 14 | 108460 | 718 | 63379830 |
Temperature intolerance | 21.02 | 10.27 | 47 | 108427 | 8917 | 63371631 |
Fluid retention | 21.01 | 10.27 | 44 | 108430 | 59642 | 63320906 |
Basal cell carcinoma | 20.66 | 10.27 | 11 | 108463 | 27980 | 63352568 |
Lymphomatoid papulosis | 20.60 | 10.27 | 8 | 108466 | 127 | 63380421 |
Stress | 20.58 | 10.27 | 190 | 108284 | 66977 | 63313571 |
Wrong patient received product | 20.58 | 10.27 | 22 | 108452 | 2185 | 63378363 |
Insomnia | 20.51 | 10.27 | 497 | 107977 | 214755 | 63165793 |
Self-injurious ideation | 20.49 | 10.27 | 24 | 108450 | 2635 | 63377913 |
Hallucination, visual | 20.45 | 10.27 | 76 | 108398 | 19222 | 63361326 |
Magnetic resonance imaging head abnormal | 20.44 | 10.27 | 21 | 108453 | 1992 | 63378556 |
Transferrin saturation decreased | 20.39 | 10.27 | 14 | 108460 | 758 | 63379790 |
Post-traumatic stress disorder | 20.27 | 10.27 | 34 | 108440 | 5217 | 63375331 |
Depressed level of consciousness | 20.25 | 10.27 | 178 | 108296 | 61900 | 63318648 |
Platelet count decreased | 20.18 | 10.27 | 116 | 108358 | 116006 | 63264542 |
Aspartate aminotransferase decreased | 20.13 | 10.27 | 14 | 108460 | 774 | 63379774 |
Hyporesponsive to stimuli | 20.10 | 10.27 | 16 | 108458 | 1088 | 63379460 |
Dyspnoea exertional | 19.95 | 10.27 | 46 | 108428 | 60256 | 63320292 |
Irritable bowel syndrome | 19.87 | 10.27 | 73 | 108401 | 82339 | 63298209 |
Blood bilirubin decreased | 19.86 | 10.27 | 14 | 108460 | 791 | 63379757 |
Hyperacusis | 19.59 | 10.27 | 21 | 108453 | 2092 | 63378456 |
Metastases to liver | 19.44 | 10.27 | 8 | 108466 | 23631 | 63356917 |
Complex regional pain syndrome | 19.39 | 10.27 | 22 | 108452 | 2335 | 63378213 |
Product counterfeit | 19.38 | 10.27 | 8 | 108466 | 150 | 63380398 |
Fear | 19.20 | 10.27 | 65 | 108409 | 15701 | 63364847 |
Metastases to bone | 19.18 | 10.27 | 6 | 108468 | 21013 | 63359535 |
Ureterolithiasis | 19.16 | 10.27 | 20 | 108454 | 1932 | 63378616 |
Acidosis | 19.03 | 10.27 | 52 | 108422 | 11181 | 63369367 |
Sinus tachycardia | 18.95 | 10.27 | 87 | 108387 | 24181 | 63356367 |
Myocardial infarction | 18.89 | 10.27 | 97 | 108377 | 99796 | 63280752 |
Cellulitis | 18.85 | 10.27 | 74 | 108400 | 81884 | 63298664 |
Product dispensing error | 18.77 | 10.27 | 49 | 108425 | 10256 | 63370292 |
Myocarditis | 18.70 | 10.27 | 49 | 108425 | 10276 | 63370272 |
Blood chloride increased | 18.68 | 10.27 | 23 | 108451 | 2661 | 63377887 |
Toxic epidermal necrolysis | 18.64 | 10.27 | 10 | 108464 | 25324 | 63355224 |
Inflammation | 18.47 | 10.27 | 75 | 108399 | 82198 | 63298350 |
Tinnitus | 18.41 | 10.27 | 114 | 108360 | 35514 | 63345034 |
Night blindness | 18.32 | 10.27 | 11 | 108463 | 472 | 63380076 |
Inappropriate affect | 18.27 | 10.27 | 14 | 108460 | 900 | 63379648 |
Disseminated intravascular coagulation | 18.19 | 10.27 | 5 | 108469 | 19046 | 63361502 |
Creatinine renal clearance decreased | 18.18 | 10.27 | 3 | 108471 | 16305 | 63364243 |
Plasmodium falciparum infection | 18.12 | 10.27 | 5 | 108469 | 24 | 63380524 |
Pulmonary oedema | 18.04 | 10.27 | 42 | 108432 | 54831 | 63325717 |
Lethargy | 17.96 | 10.27 | 160 | 108314 | 55847 | 63324701 |
Urine calcium/creatinine ratio increased | 17.92 | 10.27 | 7 | 108467 | 113 | 63380435 |
Benzodiazepine drug level increased | 17.88 | 10.27 | 8 | 108466 | 184 | 63380364 |
Enuresis | 17.83 | 10.27 | 22 | 108452 | 2551 | 63377997 |
Hyperphosphaturia | 17.79 | 10.27 | 5 | 108469 | 26 | 63380522 |
Blood thyroid stimulating hormone normal | 17.75 | 10.27 | 7 | 108467 | 116 | 63380432 |
Stillbirth | 17.67 | 10.27 | 37 | 108437 | 6713 | 63373835 |
Anticonvulsant drug level increased | 17.57 | 10.27 | 17 | 108457 | 1500 | 63379048 |
Hyperuricosuria | 17.46 | 10.27 | 4 | 108470 | 7 | 63380541 |
Osmotic demyelination syndrome | 17.46 | 10.27 | 12 | 108462 | 651 | 63379897 |
Prescribed underdose | 17.46 | 10.27 | 15 | 108459 | 29674 | 63350874 |
Nodular rash | 17.38 | 10.27 | 8 | 108466 | 197 | 63380351 |
Lactic acidosis | 17.36 | 10.27 | 24 | 108450 | 38263 | 63342285 |
Gallbladder disorder | 17.36 | 10.27 | 71 | 108403 | 18771 | 63361777 |
Ischaemic cerebral infarction | 17.34 | 10.27 | 16 | 108458 | 1330 | 63379218 |
Near drowning | 17.33 | 10.27 | 5 | 108469 | 29 | 63380519 |
Maternal exposure during pregnancy | 17.31 | 10.27 | 268 | 108206 | 219794 | 63160754 |
Cerebral venous sinus thrombosis | 17.24 | 10.27 | 19 | 108455 | 1953 | 63378595 |
Cholestasis | 17.15 | 10.27 | 15 | 108459 | 29419 | 63351129 |
Type 2 diabetes mellitus | 17.15 | 10.27 | 54 | 108420 | 63814 | 63316734 |
Congenital diaphragmatic eventration | 17.12 | 10.27 | 4 | 108470 | 8 | 63380540 |
Neutrophil count decreased | 17.11 | 10.27 | 45 | 108429 | 56361 | 63324187 |
Idiopathic intracranial hypertension | 17.07 | 10.27 | 23 | 108451 | 2908 | 63377640 |
Narcolepsy | 17.02 | 10.27 | 16 | 108458 | 1362 | 63379186 |
Pneumocystis jirovecii pneumonia | 16.99 | 10.27 | 4 | 108470 | 16910 | 63363638 |
Calculus urinary | 16.96 | 10.27 | 16 | 108458 | 1368 | 63379180 |
Liver disorder | 16.93 | 10.27 | 42 | 108432 | 53645 | 63326903 |
Ovarian germ cell cancer stage II | 16.90 | 10.27 | 6 | 108468 | 73 | 63380475 |
Dystonia | 16.85 | 10.27 | 57 | 108417 | 13762 | 63366786 |
Hypotonia | 16.75 | 10.27 | 44 | 108430 | 9241 | 63371307 |
Congenital mitral valve incompetence | 16.66 | 10.27 | 5 | 108469 | 34 | 63380514 |
Blood pressure diastolic decreased | 16.65 | 10.27 | 9 | 108465 | 22697 | 63357851 |
Productive cough | 16.58 | 10.27 | 54 | 108420 | 63154 | 63317394 |
Personality disorder | 16.57 | 10.27 | 33 | 108441 | 5778 | 63374770 |
Hyperventilation | 16.57 | 10.27 | 34 | 108440 | 6082 | 63374466 |
Pulmonary arterial hypertension | 16.48 | 10.27 | 9 | 108465 | 22568 | 63357980 |
Restless legs syndrome | 16.42 | 10.27 | 69 | 108405 | 18462 | 63362086 |
Gambling disorder | 16.36 | 10.27 | 15 | 108459 | 1237 | 63379311 |
Eating disorder | 16.23 | 10.27 | 70 | 108404 | 18946 | 63361602 |
Ejection fraction decreased | 16.16 | 10.27 | 9 | 108465 | 22323 | 63358225 |
Hydrocele | 16.12 | 10.27 | 3 | 108471 | 0 | 63380548 |
Carbon dioxide decreased | 16.11 | 10.27 | 19 | 108455 | 2102 | 63378446 |
Shock | 16.07 | 10.27 | 81 | 108393 | 23382 | 63357166 |
Bursitis | 16.02 | 10.27 | 24 | 108450 | 37017 | 63343531 |
Psychomotor skills impaired | 16.01 | 10.27 | 20 | 108454 | 2348 | 63378200 |
Neuropathy peripheral | 15.98 | 10.27 | 121 | 108353 | 113546 | 63267002 |
Retinal detachment | 15.95 | 10.27 | 33 | 108441 | 5936 | 63374612 |
Pain | 15.94 | 10.27 | 1071 | 107403 | 739557 | 62640991 |
Cytomegalovirus infection | 15.81 | 10.27 | 8 | 108466 | 20944 | 63359604 |
Failed induction of labour | 15.76 | 10.27 | 9 | 108465 | 351 | 63380197 |
Posterior reversible encephalopathy syndrome | 15.74 | 10.27 | 5 | 108469 | 17340 | 63363208 |
Occipital neuralgia | 15.74 | 10.27 | 10 | 108464 | 475 | 63380073 |
Congenital anomaly in offspring | 15.73 | 10.27 | 7 | 108467 | 159 | 63380389 |
Herpes zoster | 15.63 | 10.27 | 80 | 108394 | 82382 | 63298166 |
Hypophosphataemia | 15.62 | 10.27 | 49 | 108425 | 11377 | 63369171 |
Electrocardiogram QT prolonged | 15.60 | 10.27 | 163 | 108311 | 59367 | 63321181 |
White blood cell count decreased | 15.60 | 10.27 | 157 | 108317 | 138947 | 63241601 |
Blood pressure diastolic abnormal | 15.51 | 10.27 | 3 | 108471 | 14539 | 63366009 |
Blunted affect | 15.49 | 10.27 | 8 | 108466 | 255 | 63380293 |
Acute myeloid leukaemia | 15.46 | 10.27 | 5 | 108469 | 17142 | 63363406 |
Therapeutic product effective for unapproved indication | 15.41 | 10.27 | 6 | 108468 | 96 | 63380452 |
Blood lactic acid increased | 15.34 | 10.27 | 36 | 108438 | 7050 | 63373498 |
Blastocystis infection | 15.34 | 10.27 | 5 | 108469 | 46 | 63380502 |
Vascular malformation | 15.31 | 10.27 | 9 | 108465 | 371 | 63380177 |
Glycosuria | 15.29 | 10.27 | 14 | 108460 | 1152 | 63379396 |
Dysstasia | 15.16 | 10.27 | 74 | 108400 | 21092 | 63359456 |
Pneumonitis | 15.06 | 10.27 | 23 | 108451 | 35199 | 63345349 |
Self esteem decreased | 14.99 | 10.27 | 11 | 108463 | 662 | 63379886 |
Pregnancy | 14.93 | 10.27 | 111 | 108363 | 36725 | 63343823 |
Regressive behaviour | 14.93 | 10.27 | 7 | 108467 | 180 | 63380368 |
Diverticulitis | 14.92 | 10.27 | 28 | 108446 | 39529 | 63341019 |
Endometriosis | 14.91 | 10.27 | 30 | 108444 | 5290 | 63375258 |
Osteonecrosis | 14.91 | 10.27 | 12 | 108462 | 24518 | 63356030 |
Hip fracture | 14.90 | 10.27 | 17 | 108457 | 29457 | 63351091 |
Basilar migraine | 14.88 | 10.27 | 5 | 108469 | 51 | 63380497 |
Potassium wasting nephropathy | 14.88 | 10.27 | 5 | 108469 | 51 | 63380497 |
Cerebral vasoconstriction | 14.87 | 10.27 | 14 | 108460 | 1194 | 63379354 |
Psychomotor retardation | 14.86 | 10.27 | 25 | 108449 | 3845 | 63376703 |
Central obesity | 14.74 | 10.27 | 14 | 108460 | 1207 | 63379341 |
Macular degeneration | 14.72 | 10.27 | 12 | 108462 | 24364 | 63356184 |
Parasomnia | 14.69 | 10.27 | 10 | 108464 | 534 | 63380014 |
Pregnancy on oral contraceptive | 14.68 | 10.27 | 13 | 108461 | 1024 | 63379524 |
Photopsia | 14.57 | 10.27 | 27 | 108447 | 4482 | 63376066 |
Poisoning | 14.55 | 10.27 | 54 | 108420 | 13646 | 63366902 |
Negativism | 14.54 | 10.27 | 9 | 108465 | 408 | 63380140 |
Respiratory disorder neonatal | 14.51 | 10.27 | 14 | 108460 | 1231 | 63379317 |
Poor quality sleep | 14.49 | 10.27 | 70 | 108404 | 19865 | 63360683 |
Mastoiditis | 14.49 | 10.27 | 13 | 108461 | 1042 | 63379506 |
Hallucinations, mixed | 14.47 | 10.27 | 28 | 108446 | 4801 | 63375747 |
Blood lactate dehydrogenase increased | 14.44 | 10.27 | 11 | 108463 | 23105 | 63357443 |
Intracranial hypotension | 14.40 | 10.27 | 8 | 108466 | 296 | 63380252 |
Tenosynovitis | 14.39 | 10.27 | 3 | 108471 | 13792 | 63366756 |
Full blood count decreased | 14.29 | 10.27 | 14 | 108460 | 26010 | 63354538 |
Laryngeal stenosis | 14.25 | 10.27 | 13 | 108461 | 1065 | 63379483 |
Drug tolerance decreased | 14.23 | 10.27 | 6 | 108468 | 17467 | 63363081 |
Atrioventricular septal defect | 14.11 | 10.27 | 8 | 108466 | 308 | 63380240 |
Heart rate decreased | 14.09 | 10.27 | 36 | 108438 | 45524 | 63335024 |
Musculoskeletal pain | 14.05 | 10.27 | 96 | 108378 | 92181 | 63288367 |
Pleural rub | 14.00 | 10.27 | 5 | 108469 | 62 | 63380486 |
Obsessive thoughts | 13.94 | 10.27 | 10 | 108464 | 581 | 63379967 |
Illogical thinking | 13.93 | 10.27 | 5 | 108469 | 63 | 63380485 |
Balance disorder | 13.91 | 10.27 | 212 | 108262 | 84210 | 63296338 |
Haematochezia | 13.87 | 10.27 | 46 | 108428 | 53498 | 63327050 |
Drug level decreased | 13.76 | 10.27 | 37 | 108437 | 7882 | 63372666 |
Prinzmetal angina | 13.75 | 10.27 | 11 | 108463 | 753 | 63379795 |
Atrial septal defect | 13.68 | 10.27 | 34 | 108440 | 6904 | 63373644 |
Communication disorder | 13.63 | 10.27 | 19 | 108455 | 2481 | 63378067 |
Hypercalcaemia | 13.61 | 10.27 | 17 | 108457 | 28305 | 63352243 |
Self-medication | 13.60 | 10.27 | 20 | 108454 | 2743 | 63377805 |
Body temperature decreased | 13.57 | 10.27 | 9 | 108465 | 20310 | 63360238 |
Asthenia | 13.57 | 10.27 | 527 | 107947 | 383077 | 62997471 |
Housebound | 13.44 | 10.27 | 7 | 108467 | 227 | 63380321 |
Blood bilirubin increased | 13.39 | 10.27 | 27 | 108447 | 37113 | 63343435 |
Altered visual depth perception | 13.37 | 10.27 | 8 | 108466 | 341 | 63380207 |
Developmental hip dysplasia | 13.37 | 10.27 | 14 | 108460 | 1358 | 63379190 |
Dysmorphism | 13.35 | 10.27 | 18 | 108456 | 2278 | 63378270 |
Severe myoclonic epilepsy of infancy | 13.32 | 10.27 | 5 | 108469 | 72 | 63380476 |
Familial periodic paralysis | 13.32 | 10.27 | 5 | 108469 | 72 | 63380476 |
Wrong technique in product usage process | 13.31 | 10.27 | 164 | 108310 | 62176 | 63318372 |
Cleft lip and palate | 13.30 | 10.27 | 10 | 108464 | 625 | 63379923 |
Hepatotoxicity | 13.29 | 10.27 | 27 | 108447 | 37014 | 63343534 |
Optic neuritis | 13.26 | 10.27 | 38 | 108436 | 8397 | 63372151 |
Gastrointestinal mucosal exfoliation | 13.25 | 10.27 | 6 | 108468 | 142 | 63380406 |
Application site erythema | 13.24 | 10.27 | 27 | 108447 | 4808 | 63375740 |
High-pitched crying | 13.23 | 10.27 | 4 | 108470 | 28 | 63380520 |
Treatment failure | 13.19 | 10.27 | 250 | 108224 | 198793 | 63181755 |
Anhedonia | 13.15 | 10.27 | 45 | 108429 | 10929 | 63369619 |
Hyperaldosteronism | 13.11 | 10.27 | 7 | 108467 | 239 | 63380309 |
Seizure cluster | 13.06 | 10.27 | 7 | 108467 | 241 | 63380307 |
Toxic skin eruption | 13.04 | 10.27 | 3 | 108471 | 12882 | 63367666 |
Epistaxis | 12.98 | 10.27 | 72 | 108402 | 72653 | 63307895 |
Cleft palate | 12.98 | 10.27 | 12 | 108462 | 1000 | 63379548 |
Red blood cell sedimentation rate abnormal | 12.89 | 10.27 | 9 | 108465 | 19773 | 63360775 |
Crystal urine present | 12.87 | 10.27 | 15 | 108459 | 1639 | 63378909 |
Conjunctival hyperaemia | 12.85 | 10.27 | 18 | 108456 | 2361 | 63378187 |
Hereditary angioedema | 12.80 | 10.27 | 35 | 108439 | 7527 | 63373021 |
Bipolar II disorder | 12.80 | 10.27 | 8 | 108466 | 369 | 63380179 |
Slow response to stimuli | 12.78 | 10.27 | 12 | 108462 | 1020 | 63379528 |
Suspiciousness | 12.76 | 10.27 | 8 | 108466 | 371 | 63380177 |
Rales | 12.76 | 10.27 | 3 | 108471 | 12694 | 63367854 |
Gingival hypertrophy | 12.74 | 10.27 | 15 | 108459 | 1656 | 63378892 |
Accommodation disorder | 12.72 | 10.27 | 8 | 108466 | 373 | 63380175 |
Lung neoplasm malignant | 12.71 | 10.27 | 9 | 108465 | 19624 | 63360924 |
Neonatal seizure | 12.70 | 10.27 | 9 | 108465 | 513 | 63380035 |
Speech disorder developmental | 12.69 | 10.27 | 10 | 108464 | 670 | 63379878 |
Psoriatic arthropathy | 12.59 | 10.27 | 98 | 108376 | 91422 | 63289126 |
Drug level increased | 12.54 | 10.27 | 74 | 108400 | 22662 | 63357886 |
Pulmonary hypertension | 12.54 | 10.27 | 28 | 108446 | 37095 | 63343453 |
Lack of spontaneous speech | 12.49 | 10.27 | 6 | 108468 | 163 | 63380385 |
Disinhibition | 12.36 | 10.27 | 11 | 108463 | 872 | 63379676 |
Hemiparesis | 12.35 | 10.27 | 75 | 108399 | 23207 | 63357341 |
Sciatica | 12.33 | 10.27 | 25 | 108449 | 34299 | 63346249 |
Rheumatoid nodule | 12.29 | 10.27 | 7 | 108467 | 17148 | 63363400 |
Educational problem | 12.26 | 10.27 | 8 | 108466 | 398 | 63380150 |
Tri-iodothyronine free abnormal | 12.25 | 10.27 | 4 | 108470 | 37 | 63380511 |
Paranasal cyst | 12.24 | 10.27 | 8 | 108466 | 399 | 63380149 |
Joint range of motion decreased | 12.19 | 10.27 | 23 | 108451 | 32405 | 63348143 |
Femur fracture | 12.15 | 10.27 | 34 | 108440 | 41722 | 63338826 |
Necrotising retinitis | 12.15 | 10.27 | 8 | 108466 | 404 | 63380144 |
Sopor | 12.14 | 10.27 | 72 | 108402 | 22092 | 63358456 |
Impaired driving ability | 12.13 | 10.27 | 25 | 108449 | 4486 | 63376062 |
Cerebellar infarction | 12 | 10.27 | 16 | 108458 | 2003 | 63378545 |
Coordination abnormal | 11.98 | 10.27 | 51 | 108423 | 13722 | 63366826 |
Night sweats | 11.92 | 10.27 | 43 | 108431 | 48771 | 63331777 |
Blood cholesterol increased | 11.89 | 10.27 | 103 | 108371 | 93929 | 63286619 |
Dropped head syndrome | 11.86 | 10.27 | 6 | 108468 | 183 | 63380365 |
Hyphaema | 11.83 | 10.27 | 7 | 108467 | 292 | 63380256 |
Enlarged uvula | 11.83 | 10.27 | 6 | 108468 | 184 | 63380364 |
Myelodysplastic syndrome | 11.77 | 10.27 | 7 | 108467 | 16747 | 63363801 |
Corneal disorder | 11.75 | 10.27 | 15 | 108459 | 1799 | 63378749 |
Congenital hand malformation | 11.75 | 10.27 | 7 | 108467 | 296 | 63380252 |
Impulsive behaviour | 11.72 | 10.27 | 14 | 108460 | 1569 | 63378979 |
Serum ferritin decreased | 11.69 | 10.27 | 16 | 108458 | 2054 | 63378494 |
Oxygen saturation decreased | 11.66 | 10.27 | 96 | 108378 | 88489 | 63292059 |
Renal pain | 11.63 | 10.27 | 31 | 108443 | 6568 | 63373980 |
Depersonalisation/derealisation disorder | 11.61 | 10.27 | 13 | 108461 | 1359 | 63379189 |
Psychotic behaviour | 11.58 | 10.27 | 9 | 108465 | 591 | 63379957 |
Immune thrombocytopenia | 11.54 | 10.27 | 42 | 108432 | 10514 | 63370034 |
Personality change | 11.53 | 10.27 | 32 | 108442 | 6941 | 63373607 |
Bone pain | 11.53 | 10.27 | 51 | 108423 | 54590 | 63325958 |
Hypoalbuminaemia | 11.45 | 10.27 | 3 | 108471 | 11802 | 63368746 |
Behaviour disorder | 11.41 | 10.27 | 20 | 108454 | 3179 | 63377369 |
Granulocytopenia | 11.40 | 10.27 | 28 | 108446 | 5644 | 63374904 |
Staring | 11.39 | 10.27 | 14 | 108460 | 1616 | 63378932 |
Sleep apnoea syndrome | 11.36 | 10.27 | 87 | 108387 | 29046 | 63351502 |
Vertebral osteophyte | 11.28 | 10.27 | 7 | 108467 | 319 | 63380229 |
Pregnancy with implant contraceptive | 11.21 | 10.27 | 18 | 108456 | 2665 | 63377883 |
Gallbladder cholesterolosis | 11.20 | 10.27 | 10 | 108464 | 796 | 63379752 |
Transfusion | 11.20 | 10.27 | 6 | 108468 | 15211 | 63365337 |
Eczema | 11.20 | 10.27 | 24 | 108450 | 32267 | 63348281 |
Blood pressure fluctuation | 11.18 | 10.27 | 41 | 108433 | 46276 | 63334272 |
Coma acidotic | 11.18 | 10.27 | 5 | 108469 | 115 | 63380433 |
Cytopenia | 11.16 | 10.27 | 3 | 108471 | 11598 | 63368950 |
Cardiac arrest | 11.13 | 10.27 | 221 | 108253 | 92324 | 63288224 |
Delayed sleep phase | 11.12 | 10.27 | 3 | 108471 | 13 | 63380535 |
Sialoadenitis | 11.11 | 10.27 | 14 | 108460 | 1658 | 63378890 |
Bed rest | 11.10 | 10.27 | 4 | 108470 | 51 | 63380497 |
Calcinosis | 11.09 | 10.27 | 16 | 108458 | 2156 | 63378392 |
Social avoidant behaviour | 11.08 | 10.27 | 19 | 108455 | 2969 | 63377579 |
Spinal fracture | 11.03 | 10.27 | 9 | 108465 | 18262 | 63362286 |
Retinal disorder | 10.99 | 10.27 | 14 | 108460 | 1676 | 63378872 |
Chorioretinal folds | 10.94 | 10.27 | 3 | 108471 | 14 | 63380534 |
Breast cancer | 10.93 | 10.27 | 44 | 108430 | 48339 | 63332209 |
Application site burn | 10.91 | 10.27 | 10 | 108464 | 824 | 63379724 |
Incoherent | 10.90 | 10.27 | 24 | 108450 | 4506 | 63376042 |
Mean cell haemoglobin concentration decreased | 10.89 | 10.27 | 21 | 108453 | 3591 | 63376957 |
Localised infection | 10.86 | 10.27 | 22 | 108452 | 30188 | 63350360 |
Therapeutic product ineffective for unapproved indication | 10.85 | 10.27 | 6 | 108468 | 220 | 63380328 |
Panniculitis | 10.85 | 10.27 | 3 | 108471 | 11382 | 63369166 |
Joint effusion | 10.81 | 10.27 | 8 | 108466 | 17052 | 63363496 |
Developmental delay | 10.79 | 10.27 | 13 | 108461 | 1470 | 63379078 |
Decreased nasolabial fold | 10.77 | 10.27 | 3 | 108471 | 15 | 63380533 |
Congenital floppy infant | 10.77 | 10.27 | 3 | 108471 | 15 | 63380533 |
Hyperbilirubinaemia | 10.74 | 10.27 | 3 | 108471 | 11311 | 63369237 |
Psychiatric symptom | 10.73 | 10.27 | 26 | 108448 | 5197 | 63375351 |
Eyelid ptosis | 10.71 | 10.27 | 32 | 108442 | 7235 | 63373313 |
Threatened labour | 10.71 | 10.27 | 10 | 108464 | 844 | 63379704 |
Pulmonary eosinophilia | 10.69 | 10.27 | 7 | 108467 | 350 | 63380198 |
Emotional poverty | 10.66 | 10.27 | 7 | 108467 | 352 | 63380196 |
Oral candidiasis | 10.63 | 10.27 | 14 | 108460 | 22784 | 63357764 |
International normalised ratio increased | 10.62 | 10.27 | 42 | 108432 | 46383 | 63334165 |
Periarthritis | 10.60 | 10.27 | 16 | 108458 | 2245 | 63378303 |
Burning mouth syndrome | 10.60 | 10.27 | 8 | 108466 | 503 | 63380045 |
Drop attacks | 10.56 | 10.27 | 9 | 108465 | 673 | 63379875 |
Exophthalmos | 10.56 | 10.27 | 13 | 108461 | 1503 | 63379045 |
Conversion disorder | 10.52 | 10.27 | 14 | 108460 | 1750 | 63378798 |
Rickets | 10.51 | 10.27 | 4 | 108470 | 60 | 63380488 |
Cervicogenic headache | 10.46 | 10.27 | 3 | 108471 | 17 | 63380531 |
Congenital anomaly | 10.44 | 10.27 | 14 | 108460 | 1762 | 63378786 |
Restlessness | 10.42 | 10.27 | 86 | 108388 | 29367 | 63351181 |
Bone density decreased | 10.41 | 10.27 | 6 | 108468 | 14606 | 63365942 |
Haematoma | 10.40 | 10.27 | 28 | 108446 | 34792 | 63345756 |
Cluster headache | 10.39 | 10.27 | 9 | 108465 | 688 | 63379860 |
Automatism | 10.39 | 10.27 | 4 | 108470 | 62 | 63380486 |
Middle insomnia | 10.38 | 10.27 | 46 | 108428 | 12597 | 63367951 |
Ventricular septal defect | 10.32 | 10.27 | 23 | 108451 | 4355 | 63376193 |
Broad ligament tear | 10.32 | 10.27 | 3 | 108471 | 18 | 63380530 |
Social fear | 10.32 | 10.27 | 3 | 108471 | 18 | 63380530 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1001.68 | 13.17 | 824 | 33440 | 104033 | 34818634 |
Drug ineffective | 374.64 | 13.17 | 1134 | 33130 | 455617 | 34467050 |
Status epilepticus | 341.95 | 13.17 | 190 | 34074 | 12424 | 34910243 |
Angle closure glaucoma | 285.63 | 13.17 | 82 | 34182 | 875 | 34921792 |
Multiple-drug resistance | 279.37 | 13.17 | 125 | 34139 | 5114 | 34917553 |
Sedation | 257.70 | 13.17 | 192 | 34072 | 20814 | 34901853 |
Aggression | 254.80 | 13.17 | 248 | 34016 | 38716 | 34883951 |
Nephrolithiasis | 254.60 | 13.17 | 222 | 34042 | 30111 | 34892556 |
Heat stroke | 245.29 | 13.17 | 73 | 34191 | 892 | 34921775 |
Somnolence | 177.84 | 13.17 | 358 | 33906 | 110758 | 34811909 |
Hyperammonaemia | 175.49 | 13.17 | 97 | 34167 | 6270 | 34916397 |
Generalised tonic-clonic seizure | 165.70 | 13.17 | 149 | 34115 | 21025 | 34901642 |
Epilepsy | 157.93 | 13.17 | 146 | 34118 | 21349 | 34901318 |
Myopia | 156.76 | 13.17 | 54 | 34210 | 1082 | 34921585 |
Migraine | 150.78 | 13.17 | 130 | 34134 | 17348 | 34905319 |
Ataxia | 133.83 | 13.17 | 110 | 34154 | 13743 | 34908924 |
Hyperammonaemic encephalopathy | 128.85 | 13.17 | 57 | 34207 | 2267 | 34920400 |
Product substitution issue | 127.62 | 13.17 | 94 | 34170 | 10001 | 34912666 |
Foetal exposure during pregnancy | 126.77 | 13.17 | 171 | 34093 | 37930 | 34884737 |
Cognitive disorder | 116.24 | 13.17 | 142 | 34122 | 28551 | 34894116 |
Choroidal effusion | 112.13 | 13.17 | 28 | 34236 | 165 | 34922502 |
Drug resistance | 104.51 | 13.17 | 128 | 34136 | 25799 | 34896868 |
Hypospadias | 102.84 | 13.17 | 54 | 34210 | 3147 | 34919520 |
Anaemia | 97.21 | 13.17 | 54 | 34210 | 233281 | 34689386 |
Petit mal epilepsy | 96.26 | 13.17 | 51 | 34213 | 3027 | 34919640 |
Dyspnoea | 93.31 | 13.17 | 141 | 34123 | 376641 | 34546026 |
Partial seizures | 90.37 | 13.17 | 57 | 34207 | 4703 | 34917964 |
Anhidrosis | 90.01 | 13.17 | 21 | 34243 | 88 | 34922579 |
Nightmare | 89.13 | 13.17 | 89 | 34175 | 14302 | 34908365 |
Febrile neutropenia | 86.48 | 13.17 | 15 | 34249 | 136834 | 34785833 |
Death | 83.91 | 13.17 | 165 | 34099 | 397884 | 34524783 |
Myokymia | 82.75 | 13.17 | 19 | 34245 | 73 | 34922594 |
Sudden unexplained death in epilepsy | 78.90 | 13.17 | 26 | 34238 | 452 | 34922215 |
Flat anterior chamber of eye | 78.57 | 13.17 | 17 | 34247 | 46 | 34922621 |
Focal dyscognitive seizures | 76.97 | 13.17 | 34 | 34230 | 1347 | 34921320 |
Acidosis hyperchloraemic | 76.77 | 13.17 | 25 | 34239 | 418 | 34922249 |
Drug ineffective for unapproved indication | 76.67 | 13.17 | 105 | 34159 | 23610 | 34899057 |
Completed suicide | 74.96 | 13.17 | 239 | 34025 | 97929 | 34824738 |
Memory impairment | 74.47 | 13.17 | 144 | 34120 | 43174 | 34879493 |
Abnormal behaviour | 73.95 | 13.17 | 106 | 34158 | 24863 | 34897804 |
Ammonia increased | 72.31 | 13.17 | 48 | 34216 | 4321 | 34918346 |
Intentional self-injury | 70.63 | 13.17 | 77 | 34187 | 13694 | 34908973 |
Hyperthermia | 70.31 | 13.17 | 68 | 34196 | 10509 | 34912158 |
Acute kidney injury | 68.97 | 13.17 | 121 | 34143 | 304867 | 34617800 |
Suicidal ideation | 67.89 | 13.17 | 133 | 34131 | 40255 | 34882412 |
Diarrhoea | 65.75 | 13.17 | 182 | 34082 | 389730 | 34532937 |
Head discomfort | 65.19 | 13.17 | 44 | 34220 | 4072 | 34918595 |
Product used for unknown indication | 63.97 | 13.17 | 27 | 34237 | 956 | 34921711 |
Disturbance in attention | 63.81 | 13.17 | 101 | 34163 | 25844 | 34896823 |
Renal tubular acidosis | 62.99 | 13.17 | 35 | 34229 | 2284 | 34920383 |
Pneumonia | 62.82 | 13.17 | 167 | 34097 | 362460 | 34560207 |
Speech disorder | 60.44 | 13.17 | 98 | 34166 | 25588 | 34897079 |
Toxicity to various agents | 59.92 | 13.17 | 368 | 33896 | 199994 | 34722673 |
Psychotic disorder | 58.50 | 13.17 | 94 | 34170 | 24358 | 34898309 |
Atrial fibrillation | 57.48 | 13.17 | 24 | 34240 | 122369 | 34800298 |
Developmental delay | 57.15 | 13.17 | 35 | 34229 | 2740 | 34919927 |
Myoclonus | 55.01 | 13.17 | 70 | 34194 | 14655 | 34908012 |
Infantile spasms | 53.86 | 13.17 | 16 | 34248 | 194 | 34922473 |
Myoclonic epilepsy | 53.47 | 13.17 | 25 | 34239 | 1132 | 34921535 |
Malignant neoplasm progression | 52.72 | 13.17 | 11 | 34253 | 88035 | 34834632 |
Tonic convulsion | 52.58 | 13.17 | 25 | 34239 | 1176 | 34921491 |
Multiple drug therapy | 52.49 | 13.17 | 19 | 34245 | 442 | 34922225 |
Irritability | 52.47 | 13.17 | 90 | 34174 | 24600 | 34898067 |
Maculopathy | 51.79 | 13.17 | 23 | 34241 | 923 | 34921744 |
Encephalopathy | 50.72 | 13.17 | 109 | 34155 | 35210 | 34887457 |
Dysmorphism | 50.61 | 13.17 | 34 | 34230 | 3122 | 34919545 |
Interstitial lung disease | 48.95 | 13.17 | 4 | 34260 | 65278 | 34857389 |
Metabolic acidosis | 48.66 | 13.17 | 122 | 34142 | 43558 | 34879109 |
Priapism | 46.85 | 13.17 | 39 | 34225 | 4955 | 34917712 |
Cleft lip | 46.42 | 13.17 | 16 | 34248 | 321 | 34922346 |
Failure to suspend medication | 45.97 | 13.17 | 17 | 34247 | 421 | 34922246 |
Organic brain syndrome | 45.51 | 13.17 | 15 | 34249 | 261 | 34922406 |
Drug withdrawal convulsions | 44.02 | 13.17 | 22 | 34242 | 1155 | 34921512 |
Agitation | 43.08 | 13.17 | 139 | 34125 | 57260 | 34865407 |
Cardiac failure congestive | 43.00 | 13.17 | 14 | 34250 | 83256 | 34839411 |
Exposure during pregnancy | 42.45 | 13.17 | 48 | 34216 | 8886 | 34913781 |
Autonomic nervous system imbalance | 42.15 | 13.17 | 28 | 34236 | 2523 | 34920144 |
Delusion of replacement | 41.71 | 13.17 | 12 | 34252 | 129 | 34922538 |
Intensive care unit acquired weakness | 40.79 | 13.17 | 20 | 34244 | 1007 | 34921660 |
Intentional overdose | 40.54 | 13.17 | 114 | 34150 | 43560 | 34879107 |
Nystagmus | 40.50 | 13.17 | 35 | 34229 | 4680 | 34917987 |
Hyperchloraemia | 40.08 | 13.17 | 16 | 34248 | 490 | 34922177 |
Angular cheilitis | 38.88 | 13.17 | 12 | 34252 | 167 | 34922500 |
Fanconi syndrome | 38.80 | 13.17 | 23 | 34241 | 1697 | 34920970 |
Off label use | 37.67 | 13.17 | 598 | 33666 | 418926 | 34503741 |
Drug interaction | 37.63 | 13.17 | 362 | 33902 | 225584 | 34697083 |
Anticonvulsant drug level increased | 37.47 | 13.17 | 22 | 34242 | 1594 | 34921073 |
Product use in unapproved indication | 37.07 | 13.17 | 219 | 34045 | 117280 | 34805387 |
Lethargy | 36.86 | 13.17 | 106 | 34158 | 41016 | 34881651 |
Abdominal pain | 36.81 | 13.17 | 65 | 34199 | 163553 | 34759114 |
Cardiac failure | 36.65 | 13.17 | 22 | 34242 | 91226 | 34831441 |
Drug level fluctuating | 36.38 | 13.17 | 15 | 34249 | 500 | 34922167 |
Nasal septum disorder | 36.19 | 13.17 | 9 | 34255 | 52 | 34922615 |
Erectile dysfunction | 35.93 | 13.17 | 69 | 34195 | 20568 | 34902099 |
Mood altered | 35.74 | 13.17 | 44 | 34220 | 8908 | 34913759 |
Pyrexia | 35.53 | 13.17 | 187 | 34077 | 332826 | 34589841 |
Small for dates baby | 35.46 | 13.17 | 30 | 34234 | 3897 | 34918770 |
Product use issue | 35.35 | 13.17 | 139 | 34125 | 63077 | 34859590 |
Hypothermia | 35.35 | 13.17 | 48 | 34216 | 10700 | 34911967 |
Partial seizures with secondary generalisation | 35.12 | 13.17 | 13 | 34251 | 323 | 34922344 |
Disease progression | 34.52 | 13.17 | 33 | 34231 | 108044 | 34814623 |
Ascites | 34.51 | 13.17 | 3 | 34261 | 46568 | 34876099 |
Blood homocysteine increased | 34.30 | 13.17 | 12 | 34252 | 252 | 34922415 |
Congenital hand malformation | 34.30 | 13.17 | 15 | 34249 | 580 | 34922087 |
Atrial septal defect | 33.90 | 13.17 | 39 | 34225 | 7353 | 34915314 |
Pleural effusion | 33.69 | 13.17 | 19 | 34245 | 81527 | 34841140 |
Patient dissatisfaction with treatment | 33.02 | 13.17 | 9 | 34255 | 78 | 34922589 |
Affective disorder | 32.75 | 13.17 | 30 | 34234 | 4330 | 34918337 |
Bladder hypertrophy | 32.48 | 13.17 | 15 | 34249 | 660 | 34922007 |
Bradyphrenia | 32.17 | 13.17 | 31 | 34233 | 4767 | 34917900 |
Urge incontinence | 32.14 | 13.17 | 14 | 34250 | 536 | 34922131 |
Haemoglobin decreased | 31.92 | 13.17 | 43 | 34221 | 120729 | 34801938 |
Depressed mood | 31.70 | 13.17 | 63 | 34201 | 19254 | 34903413 |
General physical health deterioration | 31.60 | 13.17 | 48 | 34216 | 128221 | 34794446 |
Non-24-hour sleep-wake disorder | 31.57 | 13.17 | 7 | 34257 | 22 | 34922645 |
Product administered to patient of inappropriate age | 31.49 | 13.17 | 26 | 34238 | 3265 | 34919402 |
Tremor | 30.74 | 13.17 | 161 | 34103 | 82426 | 34840241 |
Vitamin D deficiency | 30.54 | 13.17 | 35 | 34229 | 6573 | 34916094 |
Intellectual disability | 30.46 | 13.17 | 18 | 34246 | 1320 | 34921347 |
Psychogenic seizure | 30.42 | 13.17 | 12 | 34252 | 356 | 34922311 |
Hallucination, auditory | 30.13 | 13.17 | 47 | 34217 | 11870 | 34910797 |
Hypotension | 29.90 | 13.17 | 114 | 34150 | 221535 | 34701132 |
Microcephaly | 29.86 | 13.17 | 15 | 34249 | 796 | 34921871 |
Hyperexplexia | 29.69 | 13.17 | 7 | 34257 | 31 | 34922636 |
Rhinolithiasis | 29.64 | 13.17 | 5 | 34259 | 0 | 34922667 |
Pancytopenia | 29.30 | 13.17 | 30 | 34234 | 95127 | 34827540 |
Renal failure | 29.23 | 13.17 | 52 | 34212 | 130505 | 34792162 |
Cough | 29.15 | 13.17 | 65 | 34199 | 150075 | 34772592 |
Ehlers-Danlos syndrome | 28.99 | 13.17 | 7 | 34257 | 35 | 34922632 |
Staring | 28.90 | 13.17 | 18 | 34246 | 1452 | 34921215 |
Social avoidant behaviour | 28.55 | 13.17 | 24 | 34240 | 3090 | 34919577 |
Necrotising colitis | 28.40 | 13.17 | 16 | 34248 | 1072 | 34921595 |
Platelet count decreased | 28.34 | 13.17 | 46 | 34218 | 119671 | 34802996 |
Gait disturbance | 28.34 | 13.17 | 161 | 34103 | 84979 | 34837688 |
Therapeutic response unexpected | 28.26 | 13.17 | 41 | 34223 | 9716 | 34912951 |
Arthralgia | 28.06 | 13.17 | 80 | 34184 | 169961 | 34752706 |
Headache | 27.93 | 13.17 | 310 | 33954 | 200325 | 34722342 |
Behaviour disorder | 27.91 | 13.17 | 29 | 34235 | 4881 | 34917786 |
Neuroleptic malignant syndrome | 27.66 | 13.17 | 57 | 34207 | 17877 | 34904790 |
Vision blurred | 27.27 | 13.17 | 103 | 34161 | 45860 | 34876807 |
Sepsis | 27.02 | 13.17 | 79 | 34185 | 166482 | 34756185 |
Dissociation | 26.92 | 13.17 | 18 | 34246 | 1640 | 34921027 |
Accidental death | 26.90 | 13.17 | 21 | 34243 | 2435 | 34920232 |
Depression | 26.86 | 13.17 | 175 | 34089 | 96923 | 34825744 |
Oesophageal atresia | 26.57 | 13.17 | 12 | 34252 | 501 | 34922166 |
Perseveration | 26.28 | 13.17 | 8 | 34256 | 106 | 34922561 |
Hippocampal sclerosis | 26.28 | 13.17 | 8 | 34256 | 106 | 34922561 |
Phonophobia | 26.18 | 13.17 | 9 | 34255 | 179 | 34922488 |
Acid-base balance disorder mixed | 26.18 | 13.17 | 7 | 34257 | 56 | 34922611 |
Persecutory delusion | 25.99 | 13.17 | 21 | 34243 | 2559 | 34920108 |
Coagulation disorder neonatal | 25.94 | 13.17 | 6 | 34258 | 24 | 34922643 |
Psychomotor skills impaired | 25.75 | 13.17 | 25 | 34239 | 3881 | 34918786 |
Paranoia | 25.65 | 13.17 | 44 | 34220 | 12024 | 34910643 |
Myocardial infarction | 25.53 | 13.17 | 50 | 34214 | 121035 | 34801632 |
Hypoxia | 25.53 | 13.17 | 11 | 34253 | 55084 | 34867583 |
Neonatal respiratory depression | 25.43 | 13.17 | 11 | 34253 | 414 | 34922253 |
Optic atrophy | 25.38 | 13.17 | 14 | 34250 | 900 | 34921767 |
Neck pain | 25.34 | 13.17 | 68 | 34196 | 25281 | 34897386 |
Renal colic | 25.23 | 13.17 | 18 | 34246 | 1821 | 34920846 |
Overdose | 25.11 | 13.17 | 164 | 34100 | 90895 | 34831772 |
Retinogram abnormal | 25.07 | 13.17 | 8 | 34256 | 125 | 34922542 |
Asthenia | 24.85 | 13.17 | 140 | 34124 | 245111 | 34677556 |
Bicuspid aortic valve | 24.52 | 13.17 | 9 | 34255 | 218 | 34922449 |
Retinal disorder | 24.51 | 13.17 | 14 | 34250 | 963 | 34921704 |
Slow speech | 24.34 | 13.17 | 15 | 34249 | 1187 | 34921480 |
Therapeutic product effect incomplete | 24.22 | 13.17 | 106 | 34158 | 50435 | 34872232 |
Premature baby | 24.16 | 13.17 | 57 | 34207 | 19576 | 34903091 |
Madarosis | 24.15 | 13.17 | 9 | 34255 | 228 | 34922439 |
Gastrointestinal haemorrhage | 23.88 | 13.17 | 31 | 34233 | 88446 | 34834221 |
Prostate cancer | 23.63 | 13.17 | 5 | 34259 | 39644 | 34883023 |
Wrong patient received product | 23.40 | 13.17 | 20 | 34244 | 2634 | 34920033 |
Hallucination, visual | 23.37 | 13.17 | 53 | 34211 | 17738 | 34904929 |
Atonic seizures | 22.94 | 13.17 | 9 | 34255 | 263 | 34922404 |
Plagiocephaly | 22.75 | 13.17 | 11 | 34253 | 537 | 34922130 |
Hypotonia | 22.74 | 13.17 | 33 | 34231 | 7820 | 34914847 |
Low birth weight baby | 22.58 | 13.17 | 33 | 34231 | 7872 | 34914795 |
Electroencephalogram abnormal | 22.52 | 13.17 | 19 | 34245 | 2459 | 34920208 |
Urticaria | 22.41 | 13.17 | 17 | 34247 | 62360 | 34860307 |
Tooth discolouration | 22.13 | 13.17 | 10 | 34254 | 418 | 34922249 |
Aorticopulmonary septal defect | 22.03 | 13.17 | 5 | 34259 | 18 | 34922649 |
Haemoptysis | 21.73 | 13.17 | 4 | 34260 | 35002 | 34887665 |
Retinal vein occlusion | 21.70 | 13.17 | 16 | 34248 | 1703 | 34920964 |
Delusion | 21.69 | 13.17 | 42 | 34222 | 12593 | 34910074 |
Tonic clonic movements | 21.36 | 13.17 | 13 | 34251 | 1006 | 34921661 |
Dyskinesia | 21.28 | 13.17 | 59 | 34205 | 22354 | 34900313 |
Tic | 21.26 | 13.17 | 17 | 34247 | 2041 | 34920626 |
Ultrasound liver abnormal | 21.22 | 13.17 | 7 | 34257 | 122 | 34922545 |
Hyperkalaemia | 21.21 | 13.17 | 22 | 34242 | 69367 | 34853300 |
Neuromyopathy | 21.19 | 13.17 | 13 | 34251 | 1021 | 34921646 |
Hypohidrosis | 21.13 | 13.17 | 8 | 34256 | 212 | 34922455 |
COVID-19 | 21.10 | 13.17 | 27 | 34237 | 77523 | 34845144 |
Lower respiratory tract infection | 21.01 | 13.17 | 3 | 34261 | 31634 | 34891033 |
Anger | 21.01 | 13.17 | 40 | 34224 | 11844 | 34910823 |
Infusion related reaction | 21.00 | 13.17 | 13 | 34251 | 53044 | 34869623 |
Mental disorder | 20.75 | 13.17 | 46 | 34218 | 15163 | 34907504 |
Hyperthermia malignant | 20.42 | 13.17 | 17 | 34247 | 2160 | 34920507 |
Psychomotor hyperactivity | 20.34 | 13.17 | 35 | 34229 | 9587 | 34913080 |
Speech disorder developmental | 20.26 | 13.17 | 17 | 34247 | 2183 | 34920484 |
Magnetic resonance imaging head abnormal | 20.25 | 13.17 | 14 | 34250 | 1347 | 34921320 |
Blood creatinine increased | 20.21 | 13.17 | 39 | 34225 | 94937 | 34827730 |
Necrotising enterocolitis neonatal | 20.16 | 13.17 | 8 | 34256 | 241 | 34922426 |
Cleft lip and palate | 20.06 | 13.17 | 12 | 34252 | 900 | 34921767 |
Muscle twitching | 19.88 | 13.17 | 36 | 34228 | 10262 | 34912405 |
Angioedema | 19.79 | 13.17 | 6 | 34258 | 37368 | 34885299 |
Psychomotor retardation | 19.75 | 13.17 | 21 | 34243 | 3629 | 34919038 |
Ischaemic gastritis | 19.68 | 13.17 | 4 | 34260 | 7 | 34922660 |
Disorientation | 19.38 | 13.17 | 74 | 34190 | 33114 | 34889553 |
Hypercapnic coma | 19.06 | 13.17 | 7 | 34257 | 170 | 34922497 |
Insomnia | 19.01 | 13.17 | 170 | 34094 | 103737 | 34818930 |
Malaise | 18.84 | 13.17 | 106 | 34158 | 185719 | 34736948 |
Bradykinesia | 18.63 | 13.17 | 21 | 34243 | 3872 | 34918795 |
Plasma cell myeloma | 18.53 | 13.17 | 9 | 34255 | 42028 | 34880639 |
Maternal drugs affecting foetus | 18.32 | 13.17 | 21 | 34243 | 3944 | 34918723 |
Haematuria traumatic | 18.26 | 13.17 | 7 | 34257 | 192 | 34922475 |
Thinking abnormal | 18.08 | 13.17 | 26 | 34238 | 6111 | 34916556 |
Talipes | 18 | 13.17 | 15 | 34249 | 1908 | 34920759 |
Pyloric stenosis | 17.94 | 13.17 | 11 | 34253 | 863 | 34921804 |
Multiple sclerosis | 17.91 | 13.17 | 27 | 34237 | 6618 | 34916049 |
Chronic kidney disease | 17.90 | 13.17 | 9 | 34255 | 41201 | 34881466 |
Cerebrovascular accident | 17.89 | 13.17 | 35 | 34229 | 84776 | 34837891 |
Teratogenicity | 17.89 | 13.17 | 5 | 34259 | 48 | 34922619 |
Blood ketone body decreased | 17.79 | 13.17 | 3 | 34261 | 0 | 34922667 |
Therapy partial responder | 17.79 | 13.17 | 33 | 34231 | 9583 | 34913084 |
Suspiciousness | 17.78 | 13.17 | 8 | 34256 | 331 | 34922336 |
Depressed level of consciousness | 17.67 | 13.17 | 86 | 34178 | 42755 | 34879912 |
Chills | 17.48 | 13.17 | 33 | 34231 | 81010 | 34841657 |
Medication error | 17.47 | 13.17 | 60 | 34204 | 25505 | 34897162 |
Renal impairment | 17.45 | 13.17 | 42 | 34222 | 94471 | 34828196 |
Hypermetropia | 17.45 | 13.17 | 9 | 34255 | 505 | 34922162 |
Abdominal pain upper | 17.35 | 13.17 | 27 | 34237 | 71463 | 34851204 |
Dystonia | 17.35 | 13.17 | 35 | 34229 | 10810 | 34911857 |
Cryptorchism | 17.22 | 13.17 | 15 | 34249 | 2026 | 34920641 |
Suicide attempt | 17.21 | 13.17 | 80 | 34184 | 39036 | 34883631 |
Joint swelling | 17.19 | 13.17 | 20 | 34244 | 59870 | 34862797 |
Premature ejaculation | 17.15 | 13.17 | 6 | 34258 | 126 | 34922541 |
Apathy | 17.05 | 13.17 | 27 | 34237 | 6905 | 34915762 |
Distractibility | 17.03 | 13.17 | 8 | 34256 | 366 | 34922301 |
Pneumonitis | 16.95 | 13.17 | 6 | 34258 | 33872 | 34888795 |
Initial insomnia | 16.95 | 13.17 | 18 | 34246 | 3106 | 34919561 |
Body dysmorphic disorder | 16.93 | 13.17 | 6 | 34258 | 131 | 34922536 |
Body height below normal | 16.93 | 13.17 | 7 | 34257 | 235 | 34922432 |
Weight increased | 16.91 | 13.17 | 152 | 34112 | 92881 | 34829786 |
Suspected suicide | 16.83 | 13.17 | 22 | 34242 | 4726 | 34917941 |
Chronic obstructive pulmonary disease | 16.73 | 13.17 | 14 | 34250 | 48904 | 34873763 |
Paraesthesia | 16.73 | 13.17 | 114 | 34150 | 64058 | 34858609 |
C-reactive protein increased | 16.71 | 13.17 | 17 | 34247 | 54081 | 34868586 |
Cardiogenic shock | 16.61 | 13.17 | 3 | 34261 | 26615 | 34896052 |
Seizure cluster | 16.52 | 13.17 | 6 | 34258 | 141 | 34922526 |
Hypertelorism | 16.40 | 13.17 | 9 | 34255 | 573 | 34922094 |
Haematochezia | 16.31 | 13.17 | 13 | 34251 | 46521 | 34876146 |
Choroidal detachment | 16.11 | 13.17 | 8 | 34256 | 414 | 34922253 |
Anterior chamber disorder | 16.04 | 13.17 | 5 | 34259 | 72 | 34922595 |
Pre-existing condition improved | 15.99 | 13.17 | 16 | 34248 | 2576 | 34920091 |
Periventricular haemorrhage neonatal | 15.96 | 13.17 | 4 | 34260 | 24 | 34922643 |
Neonatal hypotension | 15.95 | 13.17 | 6 | 34258 | 156 | 34922511 |
Change in seizure presentation | 15.88 | 13.17 | 6 | 34258 | 158 | 34922509 |
Lip oedema | 15.88 | 13.17 | 16 | 34248 | 2597 | 34920070 |
Chest discomfort | 15.88 | 13.17 | 18 | 34246 | 54512 | 34868155 |
Hyponatraemia | 15.87 | 13.17 | 36 | 34228 | 82655 | 34840012 |
Dry mouth | 15.79 | 13.17 | 65 | 34199 | 30100 | 34892567 |
Septic shock | 15.71 | 13.17 | 29 | 34235 | 71805 | 34850862 |
Ganglioglioma | 15.71 | 13.17 | 3 | 34261 | 3 | 34922664 |
Blood bilirubin increased | 15.70 | 13.17 | 9 | 34255 | 38287 | 34884380 |
Sleep-related eating disorder | 15.64 | 13.17 | 7 | 34257 | 286 | 34922381 |
Photophobia | 15.60 | 13.17 | 26 | 34238 | 6938 | 34915729 |
Somnambulism | 15.44 | 13.17 | 17 | 34247 | 3055 | 34919612 |
Enuresis | 15.39 | 13.17 | 15 | 34249 | 2338 | 34920329 |
Developmental hip dysplasia | 15.37 | 13.17 | 7 | 34257 | 298 | 34922369 |
Vascular malformation | 15.28 | 13.17 | 5 | 34259 | 85 | 34922582 |
Hyperglycinaemia | 15.25 | 13.17 | 3 | 34261 | 4 | 34922663 |
Oedema peripheral | 15.25 | 13.17 | 63 | 34201 | 119749 | 34802918 |
Psychiatric symptom | 15.22 | 13.17 | 18 | 34246 | 3495 | 34919172 |
Dysarthria | 15.20 | 13.17 | 71 | 34193 | 34711 | 34887956 |
Pain in extremity | 15.20 | 13.17 | 68 | 34196 | 126445 | 34796222 |
Mental impairment | 14.97 | 13.17 | 32 | 34232 | 10290 | 34912377 |
Peripheral swelling | 14.95 | 13.17 | 33 | 34231 | 76508 | 34846159 |
Drug reaction with eosinophilia and systemic symptoms | 14.88 | 13.17 | 68 | 34196 | 32944 | 34889723 |
Fear | 14.65 | 13.17 | 32 | 34232 | 10444 | 34912223 |
Oedema | 14.55 | 13.17 | 14 | 34250 | 45727 | 34876940 |
Abdominal wall haematoma | 14.50 | 13.17 | 13 | 34251 | 1824 | 34920843 |
Transient epileptic amnesia | 14.50 | 13.17 | 3 | 34261 | 6 | 34922661 |
Hyperhidrosis | 14.44 | 13.17 | 125 | 34139 | 75567 | 34847100 |
Muscle contracture | 14.42 | 13.17 | 11 | 34253 | 1233 | 34921434 |
Hand fracture | 14.39 | 13.17 | 14 | 34250 | 2178 | 34920489 |
Sluggishness | 14.38 | 13.17 | 17 | 34247 | 3300 | 34919367 |
White blood cell count decreased | 14.23 | 13.17 | 47 | 34217 | 95398 | 34827269 |
Anaphylactic reaction | 14.11 | 13.17 | 7 | 34257 | 32294 | 34890373 |
Cerebellar atrophy | 14.06 | 13.17 | 8 | 34256 | 546 | 34922121 |
Neutropenia | 14.02 | 13.17 | 93 | 34171 | 156685 | 34765982 |
Coronary artery disease | 14.00 | 13.17 | 16 | 34248 | 48289 | 34874378 |
Skeletal dysplasia | 13.95 | 13.17 | 5 | 34259 | 113 | 34922554 |
Drug intolerance | 13.88 | 13.17 | 103 | 34161 | 59467 | 34863200 |
Hyperglycaemia | 13.87 | 13.17 | 11 | 34253 | 39469 | 34883198 |
Neuropathy peripheral | 13.84 | 13.17 | 39 | 34225 | 83224 | 34839443 |
Floppy infant | 13.83 | 13.17 | 5 | 34259 | 116 | 34922551 |
Neonatal cholestasis | 13.74 | 13.17 | 4 | 34260 | 45 | 34922622 |
Pseudomyopia | 13.74 | 13.17 | 4 | 34260 | 45 | 34922622 |
Essential tremor | 13.71 | 13.17 | 9 | 34255 | 795 | 34921872 |
Haematemesis | 13.71 | 13.17 | 5 | 34259 | 27706 | 34894961 |
Drop attacks | 13.68 | 13.17 | 8 | 34256 | 575 | 34922092 |
Hypotonia neonatal | 13.66 | 13.17 | 11 | 34253 | 1334 | 34921333 |
Congenital genital malformation male | 13.64 | 13.17 | 3 | 34261 | 9 | 34922658 |
Idiopathic generalised epilepsy | 13.58 | 13.17 | 4 | 34260 | 47 | 34922620 |
Melaena | 13.55 | 13.17 | 9 | 34255 | 35371 | 34887296 |
Stomatitis | 13.54 | 13.17 | 13 | 34251 | 42501 | 34880166 |
Lennox-Gastaut syndrome | 13.43 | 13.17 | 4 | 34260 | 49 | 34922618 |
Angina pectoris | 13.39 | 13.17 | 7 | 34257 | 31356 | 34891311 |
Oxygen saturation decreased | 13.37 | 13.17 | 20 | 34244 | 53798 | 34868869 |
Abdominal distension | 13.34 | 13.17 | 23 | 34241 | 58469 | 34864198 |
Cross sensitivity reaction | 13.29 | 13.17 | 11 | 34253 | 1386 | 34921281 |
Respiratory failure | 13.25 | 13.17 | 58 | 34206 | 108514 | 34814153 |
Mania | 13.24 | 13.17 | 29 | 34235 | 9482 | 34913185 |
Visual field defect | 13.22 | 13.17 | 19 | 34245 | 4464 | 34918203 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Angle closure glaucoma | 1348.37 | 10.77 | 381 | 110066 | 2595 | 79631346 |
Seizure | 1299.72 | 10.77 | 1449 | 108998 | 187385 | 79446556 |
Migraine | 684.05 | 10.77 | 719 | 109728 | 86774 | 79547167 |
Myopia | 599.25 | 10.77 | 185 | 110262 | 1771 | 79632170 |
Choroidal effusion | 522.04 | 10.77 | 132 | 110315 | 545 | 79633396 |
Completed suicide | 502.92 | 10.77 | 1074 | 109373 | 244693 | 79389248 |
Multiple-drug resistance | 457.86 | 10.77 | 230 | 110217 | 8578 | 79625363 |
Drug ineffective | 438.39 | 10.77 | 2769 | 107678 | 1078144 | 78555797 |
Drug ineffective for unapproved indication | 419.85 | 10.77 | 432 | 110015 | 50806 | 79583135 |
Status epilepticus | 408.43 | 10.77 | 312 | 110135 | 24729 | 79609212 |
Intentional self-injury | 391.60 | 10.77 | 339 | 110108 | 32080 | 79601861 |
Epilepsy | 342.88 | 10.77 | 349 | 110098 | 40511 | 79593430 |
Renal tubular acidosis | 331.44 | 10.77 | 140 | 110307 | 3474 | 79630467 |
Visual perseveration | 328.88 | 10.77 | 62 | 110385 | 20 | 79633921 |
Nephrolithiasis | 305.51 | 10.77 | 373 | 110074 | 52918 | 79581023 |
Aggression | 299.17 | 10.77 | 361 | 110086 | 50597 | 79583344 |
Suicidal ideation | 292.19 | 10.77 | 439 | 110008 | 75901 | 79558040 |
Intentional overdose | 290.31 | 10.77 | 524 | 109923 | 105436 | 79528505 |
Product substitution issue | 286.36 | 10.77 | 232 | 110215 | 20024 | 79613917 |
Somnolence | 282.00 | 10.77 | 848 | 109599 | 238133 | 79395808 |
Generalised tonic-clonic seizure | 262.55 | 10.77 | 314 | 110133 | 43596 | 79590345 |
Heat stroke | 254.81 | 10.77 | 94 | 110353 | 1609 | 79632332 |
Hyperammonaemic encephalopathy | 254.80 | 10.77 | 127 | 110320 | 4655 | 79629286 |
Toxicity to various agents | 240.75 | 10.77 | 1187 | 109260 | 420353 | 79213588 |
Memory impairment | 223.13 | 10.77 | 484 | 109963 | 111250 | 79522691 |
Hyperammonaemia | 218.72 | 10.77 | 155 | 110292 | 10938 | 79623003 |
Metabolic acidosis | 210.72 | 10.77 | 396 | 110051 | 82133 | 79551808 |
Febrile neutropenia | 201.34 | 10.77 | 38 | 110409 | 230961 | 79402980 |
Petit mal epilepsy | 195.17 | 10.77 | 113 | 110334 | 5614 | 79628327 |
Acidosis hyperchloraemic | 193.51 | 10.77 | 64 | 110383 | 778 | 79633163 |
Anaemia | 192.04 | 10.77 | 200 | 110247 | 444815 | 79189126 |
Myokymia | 188.82 | 10.77 | 42 | 110405 | 83 | 79633858 |
Acute kidney injury | 181.80 | 10.77 | 274 | 110173 | 519130 | 79114811 |
Disturbance in attention | 180.06 | 10.77 | 282 | 110165 | 50519 | 79583422 |
Cognitive disorder | 169.21 | 10.77 | 328 | 110119 | 69598 | 79564343 |
Flat anterior chamber of eye | 167.57 | 10.77 | 40 | 110407 | 122 | 79633819 |
Choroidal detachment | 165.04 | 10.77 | 53 | 110394 | 583 | 79633358 |
Depression | 164.64 | 10.77 | 665 | 109782 | 216125 | 79417816 |
Joint swelling | 161.61 | 10.77 | 100 | 110347 | 288546 | 79345395 |
Paraesthesia | 160.39 | 10.77 | 573 | 109874 | 175750 | 79458191 |
Myoclonic epilepsy | 150.21 | 10.77 | 67 | 110380 | 1903 | 79632038 |
Headache | 149.72 | 10.77 | 1471 | 108976 | 652301 | 78981640 |
Synovitis | 149.30 | 10.77 | 17 | 110430 | 150717 | 79483224 |
Ataxia | 147.92 | 10.77 | 178 | 110269 | 24861 | 79609080 |
Overdose | 147.03 | 10.77 | 574 | 109873 | 183632 | 79450309 |
Partial seizures | 146.66 | 10.77 | 112 | 110335 | 8866 | 79625075 |
Acute myopia | 145.97 | 10.77 | 34 | 110413 | 90 | 79633851 |
Pneumonia | 145.64 | 10.77 | 451 | 109996 | 659795 | 78974146 |
Psychotic disorder | 144.18 | 10.77 | 228 | 110219 | 41174 | 79592767 |
Irritability | 139.74 | 10.77 | 224 | 110223 | 40920 | 79593021 |
Product use in unapproved indication | 138.35 | 10.77 | 699 | 109748 | 249660 | 79384281 |
Maculopathy | 127.24 | 10.77 | 67 | 110380 | 2758 | 79631183 |
Malignant neoplasm progression | 125.90 | 10.77 | 19 | 110428 | 135971 | 79497970 |
Atrial fibrillation | 121.63 | 10.77 | 61 | 110386 | 197825 | 79436116 |
Drug resistance | 119.66 | 10.77 | 212 | 110235 | 42001 | 79591940 |
Blepharospasm | 118.23 | 10.77 | 83 | 110364 | 5768 | 79628173 |
Focal dyscognitive seizures | 116.24 | 10.77 | 68 | 110379 | 3444 | 79630497 |
Ciliary body disorder | 114.60 | 10.77 | 23 | 110424 | 19 | 79633922 |
Medication overuse headache | 113.50 | 10.77 | 44 | 110403 | 868 | 79633073 |
Pyrexia | 111.17 | 10.77 | 523 | 109924 | 678186 | 78955755 |
Pemphigus | 110.14 | 10.77 | 7 | 110440 | 99575 | 79534366 |
Abnormal behaviour | 109.86 | 10.77 | 188 | 110259 | 36233 | 79597708 |
Infusion related reaction | 109.07 | 10.77 | 95 | 110352 | 230142 | 79403799 |
Dyspnoea | 109.05 | 10.77 | 718 | 109729 | 856307 | 78777634 |
Sedation | 108.35 | 10.77 | 229 | 110218 | 51666 | 79582275 |
Hand deformity | 104.72 | 10.77 | 11 | 110436 | 103908 | 79530033 |
Pancytopenia | 101.98 | 10.77 | 51 | 110396 | 165694 | 79468247 |
Anhidrosis | 101.90 | 10.77 | 29 | 110418 | 203 | 79633738 |
Speech disorder | 99.78 | 10.77 | 228 | 110219 | 54217 | 79579724 |
Drug interaction | 98.60 | 10.77 | 942 | 109505 | 414241 | 79219700 |
Sudden unexplained death in epilepsy | 96.74 | 10.77 | 36 | 110411 | 632 | 79633309 |
Suicide attempt | 96.38 | 10.77 | 293 | 110154 | 82639 | 79551302 |
Tremor | 94.66 | 10.77 | 476 | 109971 | 169607 | 79464334 |
General physical health deterioration | 93.43 | 10.77 | 148 | 110299 | 275090 | 79358851 |
Wound | 93.25 | 10.77 | 23 | 110424 | 116156 | 79517785 |
Interstitial lung disease | 92.93 | 10.77 | 21 | 110426 | 112579 | 79521362 |
Arthropathy | 91.49 | 10.77 | 67 | 110380 | 177044 | 79456897 |
Fanconi syndrome | 91.12 | 10.77 | 54 | 110393 | 2802 | 79631139 |
Anorexia nervosa | 90.34 | 10.77 | 27 | 110420 | 229 | 79633712 |
Renal failure | 89.17 | 10.77 | 88 | 110359 | 200880 | 79433061 |
Pericarditis | 88.97 | 10.77 | 18 | 110429 | 104218 | 79529723 |
Cardiac failure | 88.90 | 10.77 | 52 | 110395 | 154790 | 79479151 |
Vision blurred | 87.70 | 10.77 | 334 | 110113 | 105564 | 79528377 |
Disease progression | 87.39 | 10.77 | 76 | 110371 | 184286 | 79449655 |
Hyperthermia | 87.13 | 10.77 | 116 | 110331 | 17921 | 79616020 |
Drug withdrawal convulsions | 86.99 | 10.77 | 48 | 110399 | 2172 | 79631769 |
Off label use | 86.36 | 10.77 | 1747 | 108700 | 905468 | 78728473 |
Anti-cyclic citrullinated peptide antibody positive | 85.87 | 10.77 | 8 | 110439 | 83135 | 79550806 |
Rheumatoid arthritis | 85.01 | 10.77 | 98 | 110349 | 208372 | 79425569 |
Arthralgia | 83.10 | 10.77 | 459 | 109988 | 571344 | 79062597 |
Cardiac failure congestive | 82.92 | 10.77 | 47 | 110400 | 142355 | 79491586 |
Sluggishness | 81.92 | 10.77 | 70 | 110377 | 6502 | 79627439 |
Intraocular pressure increased | 81.54 | 10.77 | 81 | 110366 | 9124 | 79624817 |
Pleural effusion | 80.30 | 10.77 | 51 | 110396 | 145211 | 79488730 |
Lower respiratory tract infection | 79.13 | 10.77 | 40 | 110407 | 129180 | 79504761 |
Peripheral swelling | 78.88 | 10.77 | 159 | 110288 | 269458 | 79364483 |
Infantile spasms | 78.85 | 10.77 | 25 | 110422 | 263 | 79633678 |
Anxiety | 77.37 | 10.77 | 599 | 109848 | 247913 | 79386028 |
Nightmare | 77.34 | 10.77 | 133 | 110314 | 25728 | 79608213 |
Corneal oedema | 77.02 | 10.77 | 47 | 110400 | 2573 | 79631368 |
Ammonia increased | 76.70 | 10.77 | 72 | 110375 | 7563 | 79626378 |
Mitochondrial DNA mutation | 76.40 | 10.77 | 27 | 110420 | 406 | 79633535 |
Tonic convulsion | 76.17 | 10.77 | 44 | 110403 | 2176 | 79631765 |
Bradyphrenia | 75.22 | 10.77 | 83 | 110364 | 10557 | 79623384 |
Diarrhoea | 75.18 | 10.77 | 819 | 109628 | 879670 | 78754271 |
Neovascularisation | 75.12 | 10.77 | 36 | 110411 | 1209 | 79632732 |
Cerebral venous thrombosis | 74.87 | 10.77 | 47 | 110400 | 2706 | 79631235 |
Haemoglobin decreased | 73.89 | 10.77 | 121 | 110326 | 221998 | 79411943 |
Sepsis | 73.71 | 10.77 | 165 | 110282 | 269263 | 79364678 |
Aphasia | 69.92 | 10.77 | 181 | 110266 | 46551 | 79587390 |
Agitation | 69.41 | 10.77 | 298 | 110149 | 99417 | 79534524 |
Slow speech | 69.15 | 10.77 | 43 | 110404 | 2435 | 79631506 |
Mood altered | 68.75 | 10.77 | 103 | 110344 | 17744 | 79616197 |
Neutropenia | 68.70 | 10.77 | 189 | 110258 | 287521 | 79346420 |
Stomatitis | 67.74 | 10.77 | 62 | 110385 | 146695 | 79487246 |
Death | 67.21 | 10.77 | 484 | 109963 | 566030 | 79067911 |
Myoclonus | 67.19 | 10.77 | 130 | 110317 | 27530 | 79606411 |
Infection | 66.95 | 10.77 | 147 | 110300 | 241565 | 79392376 |
Glossodynia | 66.31 | 10.77 | 30 | 110417 | 103307 | 79530634 |
Hyponatraemia | 65.82 | 10.77 | 90 | 110357 | 177758 | 79456183 |
Therapeutic response unexpected | 65.54 | 10.77 | 107 | 110340 | 19839 | 79614102 |
Paradoxical drug reaction | 65.08 | 10.77 | 64 | 110383 | 7121 | 79626820 |
Abdominal discomfort | 65.00 | 10.77 | 158 | 110289 | 250569 | 79383372 |
Photophobia | 64.60 | 10.77 | 108 | 110339 | 20420 | 79613521 |
Renal impairment | 63.42 | 10.77 | 75 | 110372 | 157708 | 79476233 |
Partial seizures with secondary generalisation | 62.70 | 10.77 | 26 | 110421 | 615 | 79633326 |
Hypoaesthesia | 61.86 | 10.77 | 443 | 110004 | 178909 | 79455032 |
Duodenal ulcer perforation | 61.84 | 10.77 | 9 | 110438 | 66202 | 79567739 |
Mental disorder | 61.74 | 10.77 | 135 | 110312 | 31167 | 79602774 |
Helicobacter infection | 61.68 | 10.77 | 11 | 110436 | 69693 | 79564248 |
Multiple sclerosis | 60.70 | 10.77 | 110 | 110337 | 22172 | 79611769 |
Multiple sclerosis relapse | 60.36 | 10.77 | 171 | 110276 | 46362 | 79587579 |
Depressed mood | 59.84 | 10.77 | 175 | 110272 | 48305 | 79585636 |
Visual field defect | 59.57 | 10.77 | 68 | 110379 | 8977 | 79624964 |
Diplopia | 58.95 | 10.77 | 138 | 110309 | 33328 | 79600613 |
Blood creatinine increased | 58.86 | 10.77 | 77 | 110370 | 154980 | 79478961 |
Dysarthria | 58.22 | 10.77 | 216 | 110231 | 67406 | 79566535 |
Coma blister | 58.13 | 10.77 | 19 | 110428 | 222 | 79633719 |
Visual acuity reduced | 56.88 | 10.77 | 126 | 110321 | 29343 | 79604598 |
Hyperkalaemia | 56.86 | 10.77 | 45 | 110402 | 114353 | 79519588 |
Propofol infusion syndrome | 56.83 | 10.77 | 35 | 110412 | 1948 | 79631993 |
Nystagmus | 56.20 | 10.77 | 69 | 110378 | 9835 | 79624106 |
Mania | 56.04 | 10.77 | 95 | 110352 | 18165 | 79615776 |
Paranoia | 55.59 | 10.77 | 98 | 110349 | 19334 | 79614607 |
Psychogenic seizure | 55.13 | 10.77 | 34 | 110413 | 1897 | 79632044 |
Swelling | 55.04 | 10.77 | 138 | 110309 | 216573 | 79417368 |
Blood prolactin increased | 54.70 | 10.77 | 45 | 110402 | 3966 | 79629975 |
Gastrointestinal haemorrhage | 54.40 | 10.77 | 75 | 110372 | 147644 | 79486297 |
Withdrawal syndrome | 54.31 | 10.77 | 117 | 110330 | 26737 | 79607204 |
Impaired healing | 53.86 | 10.77 | 27 | 110420 | 87628 | 79546313 |
Drug intolerance | 53.81 | 10.77 | 581 | 109866 | 263538 | 79370403 |
Visual snow syndrome | 52.77 | 10.77 | 13 | 110434 | 47 | 79633894 |
Muscle twitching | 52.52 | 10.77 | 110 | 110337 | 24654 | 79609287 |
Cough | 52.33 | 10.77 | 296 | 110151 | 366493 | 79267448 |
CSF oligoclonal band present | 51.29 | 10.77 | 20 | 110427 | 401 | 79633540 |
Blindness | 51.04 | 10.77 | 118 | 110329 | 28265 | 79605676 |
Myocardial infarction | 50.96 | 10.77 | 112 | 110335 | 184017 | 79449924 |
Feeling abnormal | 50.77 | 10.77 | 386 | 110061 | 158813 | 79475128 |
Electroencephalogram abnormal | 50.33 | 10.77 | 49 | 110398 | 5385 | 79628556 |
Oligomenorrhoea | 50.00 | 10.77 | 23 | 110424 | 703 | 79633238 |
Crying | 49.62 | 10.77 | 103 | 110344 | 22940 | 79611001 |
Iris adhesions | 49.56 | 10.77 | 21 | 110426 | 525 | 79633416 |
Contraindicated product administered | 48.57 | 10.77 | 90 | 110357 | 157448 | 79476493 |
Amenorrhoea | 47.59 | 10.77 | 56 | 110391 | 7636 | 79626305 |
Hallucination, auditory | 47.53 | 10.77 | 95 | 110352 | 20598 | 79613343 |
Retinogram abnormal | 47.40 | 10.77 | 18 | 110429 | 335 | 79633606 |
Affective disorder | 47.27 | 10.77 | 58 | 110389 | 8261 | 79625680 |
Concussion | 47.26 | 10.77 | 62 | 110385 | 9441 | 79624500 |
Weight decreased | 47.18 | 10.77 | 722 | 109725 | 354476 | 79279465 |
Muscle injury | 46.77 | 10.77 | 6 | 110441 | 48555 | 79585386 |
Angiofibroma | 46.51 | 10.77 | 14 | 110433 | 122 | 79633819 |
Benign familial pemphigus | 46.28 | 10.77 | 9 | 110438 | 5 | 79633936 |
C-reactive protein increased | 46.03 | 10.77 | 67 | 110380 | 128960 | 79504981 |
Coma | 46.00 | 10.77 | 267 | 110180 | 100382 | 79533559 |
Galactorrhoea | 45.78 | 10.77 | 39 | 110408 | 3607 | 79630334 |
Atonic seizures | 45.47 | 10.77 | 22 | 110425 | 755 | 79633186 |
Ascites | 45.34 | 10.77 | 24 | 110423 | 75538 | 79558403 |
Thrombocytopenia | 45.29 | 10.77 | 201 | 110246 | 265058 | 79368883 |
Iridocyclitis | 45.24 | 10.77 | 39 | 110408 | 3665 | 79630276 |
Pseudomyopia | 44.96 | 10.77 | 13 | 110434 | 97 | 79633844 |
Self-induced vomiting | 44.94 | 10.77 | 12 | 110435 | 64 | 79633877 |
Intellectual disability | 44.86 | 10.77 | 26 | 110421 | 1294 | 79632647 |
Folliculitis | 44.36 | 10.77 | 11 | 110436 | 55369 | 79578572 |
Encephalopathy | 44.28 | 10.77 | 198 | 110249 | 67199 | 79566742 |
Platelet count decreased | 44.15 | 10.77 | 131 | 110316 | 194533 | 79439408 |
Phonophobia | 44.04 | 10.77 | 19 | 110428 | 497 | 79633444 |
Head discomfort | 43.91 | 10.77 | 75 | 110372 | 14427 | 79619514 |
Plasma cell myeloma | 43.80 | 10.77 | 10 | 110437 | 53249 | 79580692 |
Product used for unknown indication | 43.61 | 10.77 | 27 | 110420 | 1517 | 79632424 |
Nasopharyngitis | 43.57 | 10.77 | 192 | 110255 | 253689 | 79380252 |
Alexia | 43.54 | 10.77 | 9 | 110438 | 10 | 79633931 |
Amnesia | 43.52 | 10.77 | 188 | 110259 | 62869 | 79571072 |
Suicidal behaviour | 43.38 | 10.77 | 36 | 110411 | 3211 | 79630730 |
Anticonvulsant drug level increased | 43.12 | 10.77 | 33 | 110414 | 2620 | 79631321 |
Blister | 42.66 | 10.77 | 62 | 110385 | 119414 | 79514527 |
Septic shock | 42.61 | 10.77 | 65 | 110382 | 122736 | 79511205 |
Hypomagnesaemia | 42.39 | 10.77 | 7 | 110440 | 46904 | 79587037 |
Respiratory alkalosis | 42.06 | 10.77 | 40 | 110407 | 4271 | 79629670 |
C-reactive protein abnormal | 42.00 | 10.77 | 8 | 110439 | 48359 | 79585582 |
Intentional product misuse | 41.90 | 10.77 | 250 | 110197 | 94915 | 79539026 |
Hypoxia | 41.56 | 10.77 | 49 | 110398 | 103194 | 79530747 |
Oedema peripheral | 41.38 | 10.77 | 194 | 110253 | 252094 | 79381847 |
Bulimia nervosa | 41.19 | 10.77 | 15 | 110432 | 247 | 79633694 |
Eye pain | 41.08 | 10.77 | 130 | 110317 | 37448 | 79596493 |
Bipolar disorder | 41.02 | 10.77 | 52 | 110395 | 7655 | 79626286 |
Weight increased | 40.01 | 10.77 | 572 | 109875 | 276814 | 79357127 |
Oedema | 39.87 | 10.77 | 65 | 110382 | 119515 | 79514426 |
Wrong patient received product | 39.73 | 10.77 | 40 | 110407 | 4578 | 79629363 |
Mental impairment | 39.72 | 10.77 | 84 | 110363 | 18952 | 79614989 |
Libido increased | 39.53 | 10.77 | 28 | 110419 | 1973 | 79631968 |
Rash | 39.41 | 10.77 | 564 | 109883 | 577794 | 79056147 |
Cytomegalovirus infection | 39.35 | 10.77 | 6 | 110441 | 42638 | 79591303 |
Nephrocalcinosis | 39.24 | 10.77 | 25 | 110422 | 1477 | 79632464 |
Serotonin syndrome | 38.90 | 10.77 | 144 | 110303 | 44883 | 79589058 |
Product use issue | 38.82 | 10.77 | 453 | 109994 | 209369 | 79424572 |
Aura | 38.66 | 10.77 | 21 | 110426 | 921 | 79633020 |
Anger | 38.47 | 10.77 | 78 | 110369 | 17084 | 79616857 |
Social avoidant behaviour | 38.34 | 10.77 | 40 | 110407 | 4774 | 79629167 |
Migraine with aura | 38.26 | 10.77 | 31 | 110416 | 2674 | 79631267 |
Apathy | 37.83 | 10.77 | 66 | 110381 | 12911 | 79621030 |
Cervix neoplasm | 37.76 | 10.77 | 13 | 110434 | 180 | 79633761 |
Hypertension | 37.63 | 10.77 | 286 | 110161 | 330706 | 79303235 |
Visual impairment | 37.39 | 10.77 | 237 | 110210 | 91894 | 79542047 |
Blood lactate dehydrogenase increased | 37.34 | 10.77 | 5 | 110442 | 39165 | 79594776 |
Melaena | 37.04 | 10.77 | 19 | 110428 | 60871 | 79573070 |
Haematochezia | 37.01 | 10.77 | 40 | 110407 | 87605 | 79546336 |
Respiratory arrest | 37.00 | 10.77 | 168 | 110279 | 57382 | 79576559 |
Priapism | 36.90 | 10.77 | 38 | 110409 | 4467 | 79629474 |
Discomfort | 36.77 | 10.77 | 74 | 110373 | 125543 | 79508398 |
Coronary artery disease | 36.15 | 10.77 | 23 | 110424 | 65451 | 79568490 |
Hostility | 35.94 | 10.77 | 28 | 110419 | 2282 | 79631659 |
Failure to suspend medication | 35.75 | 10.77 | 16 | 110431 | 458 | 79633483 |
Taste disorder | 35.57 | 10.77 | 72 | 110375 | 15751 | 79618190 |
Delusion of replacement | 35.48 | 10.77 | 12 | 110435 | 157 | 79633784 |
Red blood cell sedimentation rate increased | 35.14 | 10.77 | 10 | 110437 | 45932 | 79588009 |
Disorientation | 35.10 | 10.77 | 176 | 110271 | 62600 | 79571341 |
Cholecystitis chronic | 35.09 | 10.77 | 55 | 110392 | 9851 | 79624090 |
Mood swings | 35.03 | 10.77 | 82 | 110365 | 19798 | 79614143 |
Prostate cancer | 34.89 | 10.77 | 3 | 110444 | 33265 | 79600676 |
Pulmonary fibrosis | 34.87 | 10.77 | 9 | 110438 | 44103 | 79589838 |
Neoplasm progression | 34.75 | 10.77 | 14 | 110433 | 51668 | 79582273 |
Delusion | 34.65 | 10.77 | 83 | 110364 | 20340 | 79613601 |
Somnambulism | 34.32 | 10.77 | 41 | 110406 | 5680 | 79628261 |
Change in seizure presentation | 34.28 | 10.77 | 16 | 110431 | 506 | 79633435 |
Blood gases abnormal | 34.26 | 10.77 | 21 | 110426 | 1159 | 79632782 |
Post-traumatic neck syndrome | 33.93 | 10.77 | 26 | 110421 | 2068 | 79631873 |
Hepatic enzyme increased | 33.86 | 10.77 | 134 | 110313 | 182476 | 79451465 |
Osteonecrosis of jaw | 33.83 | 10.77 | 9 | 110438 | 43217 | 79590724 |
Asthenia | 33.79 | 10.77 | 502 | 109945 | 511187 | 79122754 |
Salivary gland calculus | 33.74 | 10.77 | 13 | 110434 | 252 | 79633689 |
Blood pressure systolic increased | 33.72 | 10.77 | 26 | 110421 | 66960 | 79566981 |
Malaise | 33.60 | 10.77 | 477 | 109970 | 489392 | 79144549 |
Thyroxine free decreased | 33.58 | 10.77 | 20 | 110427 | 1047 | 79632894 |
Ciliary muscle spasm | 33.50 | 10.77 | 6 | 110441 | 0 | 79633941 |
Depressed level of consciousness | 33.45 | 10.77 | 239 | 110208 | 96413 | 79537528 |
Angiomyolipoma | 33.39 | 10.77 | 12 | 110435 | 190 | 79633751 |
Hypersomnia | 33.08 | 10.77 | 88 | 110359 | 22998 | 79610943 |
Hyperchloraemia | 32.67 | 10.77 | 20 | 110427 | 1101 | 79632840 |
Lethargy | 32.30 | 10.77 | 208 | 110239 | 81084 | 79552857 |
Lennox-Gastaut syndrome | 32.28 | 10.77 | 12 | 110435 | 210 | 79633731 |
Bezoar | 32.22 | 10.77 | 28 | 110419 | 2660 | 79631281 |
Respiratory disorder neonatal | 32.13 | 10.77 | 9 | 110438 | 59 | 79633882 |
Erythema | 31.92 | 10.77 | 180 | 110267 | 223110 | 79410831 |
Upper gastrointestinal haemorrhage | 31.66 | 10.77 | 9 | 110438 | 41371 | 79592570 |
Insomnia | 31.62 | 10.77 | 496 | 109951 | 244674 | 79389267 |
Dysphemia | 31.49 | 10.77 | 31 | 110416 | 3453 | 79630488 |
Vertigo | 31.39 | 10.77 | 183 | 110264 | 68899 | 79565042 |
Psychomotor hyperactivity | 31.35 | 10.77 | 71 | 110376 | 16778 | 79617163 |
Anticonvulsant drug level decreased | 31.31 | 10.77 | 24 | 110423 | 1910 | 79632031 |
Pruritus | 31.20 | 10.77 | 373 | 110074 | 394275 | 79239666 |
Hip arthroplasty | 30.87 | 10.77 | 6 | 110441 | 35750 | 79598191 |
Systemic lupus erythematosus | 30.85 | 10.77 | 77 | 110370 | 121072 | 79512869 |
Autonomic nervous system imbalance | 30.81 | 10.77 | 35 | 110412 | 4595 | 79629346 |
Pleocytosis | 30.45 | 10.77 | 21 | 110426 | 1418 | 79632523 |
Drug abuse | 30.42 | 10.77 | 352 | 110095 | 162339 | 79471602 |
Gene mutation | 30.24 | 10.77 | 27 | 110420 | 2659 | 79631282 |
Musculoskeletal stiffness | 30.22 | 10.77 | 132 | 110315 | 174876 | 79459065 |
Retinal disorder | 30.10 | 10.77 | 24 | 110423 | 2023 | 79631918 |
Dystonia | 30.09 | 10.77 | 81 | 110366 | 21318 | 79612623 |
Alice in wonderland syndrome | 30.07 | 10.77 | 8 | 110439 | 42 | 79633899 |
Blindness transient | 29.93 | 10.77 | 35 | 110412 | 4741 | 79629200 |
Hypophosphataemic osteomalacia | 29.89 | 10.77 | 13 | 110434 | 347 | 79633594 |
Hallucination, visual | 29.39 | 10.77 | 106 | 110341 | 32623 | 79601318 |
Extrapyramidal disorder | 29.07 | 10.77 | 83 | 110364 | 22596 | 79611345 |
Pneumocystis jirovecii pneumonia | 29.04 | 10.77 | 5 | 110442 | 32503 | 79601438 |
Product administered to patient of inappropriate age | 28.82 | 10.77 | 37 | 110410 | 5516 | 79628425 |
Migraine without aura | 28.70 | 10.77 | 12 | 110435 | 290 | 79633651 |
Neutrophil count decreased | 28.66 | 10.77 | 54 | 110393 | 93905 | 79540036 |
Knee arthroplasty | 28.62 | 10.77 | 12 | 110435 | 43236 | 79590705 |
Soft tissue injury | 28.61 | 10.77 | 22 | 110425 | 1759 | 79632182 |
Skin ulcer | 28.58 | 10.77 | 20 | 110427 | 54130 | 79579811 |
Myelodysplastic syndrome | 28.57 | 10.77 | 4 | 110443 | 30297 | 79603644 |
Lung disorder | 28.56 | 10.77 | 42 | 110405 | 80515 | 79553426 |
Retinal deposits | 28.50 | 10.77 | 10 | 110437 | 147 | 79633794 |
Macular detachment | 28.42 | 10.77 | 11 | 110436 | 216 | 79633725 |
Drug withdrawal syndrome | 28.31 | 10.77 | 109 | 110338 | 34609 | 79599332 |
Hypocitraturia | 28.02 | 10.77 | 6 | 110441 | 9 | 79633932 |
Hypervolaemia | 28.00 | 10.77 | 12 | 110435 | 42678 | 79591263 |
Hyposthenuria | 27.92 | 10.77 | 5 | 110442 | 0 | 79633941 |
Rhinolithiasis | 27.92 | 10.77 | 5 | 110442 | 0 | 79633941 |
Fear | 27.74 | 10.77 | 80 | 110367 | 21906 | 79612035 |
Pneumonitis | 27.73 | 10.77 | 26 | 110421 | 60834 | 79573107 |
Lymphangioleiomyomatosis | 27.55 | 10.77 | 10 | 110437 | 163 | 79633778 |
Blood homocysteine increased | 27.51 | 10.77 | 13 | 110434 | 423 | 79633518 |
Dehydration | 27.46 | 10.77 | 216 | 110231 | 247971 | 79385970 |
Emotional distress | 27.45 | 10.77 | 119 | 110328 | 39850 | 79594091 |
Lichen planus | 27.42 | 10.77 | 26 | 110421 | 2765 | 79631176 |
Thinking abnormal | 27.37 | 10.77 | 58 | 110389 | 13103 | 79620838 |
Gait disturbance | 27.20 | 10.77 | 421 | 110026 | 207085 | 79426856 |
Acute myeloid leukaemia | 27.05 | 10.77 | 5 | 110442 | 30880 | 79603061 |
Blood pressure measurement | 27.03 | 10.77 | 13 | 110434 | 440 | 79633501 |
Simple partial seizures | 26.98 | 10.77 | 15 | 110432 | 689 | 79633252 |
Neck pain | 26.97 | 10.77 | 188 | 110259 | 75229 | 79558712 |
Abortion spontaneous | 26.87 | 10.77 | 96 | 110351 | 29411 | 79604530 |
Dizziness | 26.85 | 10.77 | 935 | 109512 | 525506 | 79108435 |
Bone marrow failure | 26.81 | 10.77 | 19 | 110428 | 51088 | 79582853 |
Pulmonary oedema | 26.68 | 10.77 | 51 | 110396 | 88203 | 79545738 |
Lactic acidosis | 26.63 | 10.77 | 35 | 110412 | 70324 | 79563617 |
Major depression | 26.61 | 10.77 | 46 | 110401 | 8934 | 79625007 |
Retinitis pigmentosa | 26.59 | 10.77 | 9 | 110438 | 118 | 79633823 |
Hyperexplexia | 26.59 | 10.77 | 7 | 110440 | 35 | 79633906 |
Product quality issue | 26.41 | 10.77 | 105 | 110342 | 33835 | 79600106 |
Blood bilirubin increased | 26.05 | 10.77 | 32 | 110415 | 66200 | 79567741 |
Peritonitis | 25.74 | 10.77 | 4 | 110443 | 28032 | 79605909 |
Psychomotor retardation | 25.71 | 10.77 | 37 | 110410 | 6147 | 79627794 |
Sternal fracture | 25.69 | 10.77 | 24 | 110423 | 2506 | 79631435 |
Toxic encephalopathy | 25.65 | 10.77 | 52 | 110395 | 11388 | 79622553 |
Biliary dyskinesia | 25.56 | 10.77 | 24 | 110423 | 2521 | 79631420 |
Hypohidrosis | 25.56 | 10.77 | 11 | 110436 | 286 | 79633655 |
Non-24-hour sleep-wake disorder | 25.52 | 10.77 | 7 | 110440 | 42 | 79633899 |
Vascular malformation | 25.52 | 10.77 | 12 | 110435 | 386 | 79633555 |
Cytokine release syndrome | 25.46 | 10.77 | 9 | 110438 | 35989 | 79597952 |
Granuloma annulare | 25.44 | 10.77 | 14 | 110433 | 630 | 79633311 |
Haemoptysis | 25.42 | 10.77 | 24 | 110423 | 55975 | 79577966 |
Seizure cluster | 25.40 | 10.77 | 12 | 110435 | 390 | 79633551 |
Suspiciousness | 25.38 | 10.77 | 14 | 110433 | 633 | 79633308 |
Renal colic | 25.27 | 10.77 | 25 | 110422 | 2802 | 79631139 |
Fluid retention | 25.14 | 10.77 | 36 | 110411 | 69773 | 79564168 |
Affect lability | 25.03 | 10.77 | 51 | 110396 | 11208 | 79622733 |
Frontal lobe epilepsy | 24.98 | 10.77 | 5 | 110442 | 4 | 79633937 |
Tearfulness | 24.89 | 10.77 | 36 | 110411 | 6009 | 79627932 |
Staring | 24.78 | 10.77 | 24 | 110423 | 2621 | 79631320 |
Conjunctival oedema | 24.74 | 10.77 | 17 | 110430 | 1141 | 79632800 |
Arthritis | 24.13 | 10.77 | 80 | 110367 | 114800 | 79519141 |
Hyperventilation | 24.11 | 10.77 | 41 | 110406 | 7858 | 79626083 |
Myelosuppression | 23.88 | 10.77 | 13 | 110434 | 40283 | 79593658 |
Hypotonia | 23.68 | 10.77 | 54 | 110393 | 12816 | 79621125 |
Heart rate | 23.56 | 10.77 | 8 | 110439 | 106 | 79633835 |
Anoxia | 23.50 | 10.77 | 11 | 110436 | 350 | 79633591 |
Hypermetropia | 23.43 | 10.77 | 12 | 110435 | 466 | 79633475 |
Granulocytopenia | 23.34 | 10.77 | 50 | 110397 | 11381 | 79622560 |
Patient dissatisfaction with treatment | 23.24 | 10.77 | 9 | 110438 | 177 | 79633764 |
Panic attack | 23.09 | 10.77 | 80 | 110367 | 24136 | 79609805 |
Gingival hypertrophy | 23.06 | 10.77 | 25 | 110422 | 3117 | 79630824 |
Neuropathy peripheral | 22.95 | 10.77 | 109 | 110338 | 141196 | 79492745 |
Intensive care unit acquired weakness | 22.90 | 10.77 | 20 | 110427 | 1913 | 79632028 |
Acute myocardial infarction | 22.86 | 10.77 | 45 | 110402 | 76991 | 79556950 |
Ill-defined disorder | 22.72 | 10.77 | 35 | 110412 | 65840 | 79568101 |
Wheezing | 22.66 | 10.77 | 84 | 110363 | 116580 | 79517361 |
Drug dependence | 22.57 | 10.77 | 114 | 110333 | 40655 | 79593286 |
Inappropriate affect | 22.57 | 10.77 | 18 | 110429 | 1518 | 79632423 |
Dyspnoea exertional | 22.44 | 10.77 | 55 | 110392 | 87018 | 79546923 |
Haematuria | 22.40 | 10.77 | 38 | 110409 | 68798 | 79565143 |
Right ventricular failure | 22.40 | 10.77 | 3 | 110444 | 23494 | 79610447 |
Behaviour disorder | 22.29 | 10.77 | 35 | 110412 | 6278 | 79627663 |
Anticonvulsant drug level above therapeutic | 22.25 | 10.77 | 16 | 110431 | 1155 | 79632786 |
Erectile dysfunction | 22.14 | 10.77 | 57 | 110390 | 14607 | 79619334 |
Road traffic accident | 22.04 | 10.77 | 119 | 110328 | 43545 | 79590396 |
Metastases to liver | 21.96 | 10.77 | 6 | 110441 | 28308 | 79605633 |
Oxygen saturation decreased | 21.87 | 10.77 | 98 | 110349 | 128949 | 79504992 |
Mobility decreased | 21.79 | 10.77 | 91 | 110356 | 122084 | 79511857 |
Liver disorder | 21.75 | 10.77 | 42 | 110405 | 72375 | 79561566 |
Temperature intolerance | 21.62 | 10.77 | 44 | 110403 | 9661 | 79624280 |
Hypothermia | 21.57 | 10.77 | 75 | 110372 | 22671 | 79611270 |
Developmental delay | 21.53 | 10.77 | 16 | 110431 | 1215 | 79632726 |
Sleep-related eating disorder | 21.48 | 10.77 | 13 | 110434 | 701 | 79633240 |
Posterior reversible encephalopathy syndrome | 21.48 | 10.77 | 5 | 110442 | 26276 | 79607665 |
Ehlers-Danlos syndrome | 21.42 | 10.77 | 8 | 110439 | 142 | 79633799 |
Neuroleptic malignant syndrome | 21.23 | 10.77 | 85 | 110362 | 27474 | 79606467 |
White blood cell count decreased | 21.23 | 10.77 | 163 | 110284 | 188125 | 79445816 |
Eating disorder | 21.17 | 10.77 | 70 | 110377 | 20627 | 79613314 |
Hypoglycaemia | 21.17 | 10.77 | 71 | 110376 | 101523 | 79532418 |
Vitamin D deficiency | 21.04 | 10.77 | 55 | 110392 | 14224 | 79619717 |
Optic atrophy | 20.91 | 10.77 | 19 | 110428 | 1914 | 79632027 |
Ejection fraction decreased | 20.72 | 10.77 | 11 | 110436 | 34566 | 79599375 |
Thalamic infarction | 20.68 | 10.77 | 16 | 110431 | 1291 | 79632650 |
Acid-base balance disorder mixed | 20.26 | 10.77 | 7 | 110440 | 98 | 79633843 |
Full blood count decreased | 20.21 | 10.77 | 6 | 110441 | 26813 | 79607128 |
Cardiogenic shock | 20.18 | 10.77 | 17 | 110430 | 41897 | 79592044 |
Blunted affect | 20.17 | 10.77 | 11 | 110436 | 486 | 79633455 |
Herpes zoster | 20.12 | 10.77 | 64 | 110383 | 93019 | 79540922 |
Screaming | 20.09 | 10.77 | 26 | 110421 | 3907 | 79630034 |
Self-injurious ideation | 20.08 | 10.77 | 25 | 110422 | 3613 | 79630328 |
Cardio-respiratory arrest | 19.93 | 10.77 | 234 | 110213 | 108276 | 79525665 |
Papilloedema | 19.89 | 10.77 | 33 | 110414 | 6200 | 79627741 |
Psychomotor skills impaired | 19.85 | 10.77 | 30 | 110417 | 5207 | 79628734 |
Microcephaly | 19.74 | 10.77 | 8 | 110439 | 178 | 79633763 |
Transfusion | 19.68 | 10.77 | 3 | 110444 | 21327 | 79612614 |
Pericardial effusion | 19.63 | 10.77 | 21 | 110426 | 46216 | 79587725 |
Hypersensitivity | 19.51 | 10.77 | 251 | 110196 | 261988 | 79371953 |
Intentional product use issue | 19.43 | 10.77 | 127 | 110320 | 151985 | 79481956 |
Exposure during pregnancy | 19.43 | 10.77 | 220 | 110227 | 100912 | 79533029 |
Speech disorder developmental | 19.42 | 10.77 | 12 | 110435 | 672 | 79633269 |
Hyperglycaemia | 19.26 | 10.77 | 43 | 110404 | 70292 | 79563649 |
Brugada syndrome | 19.25 | 10.77 | 15 | 110432 | 1223 | 79632718 |
Apnoea | 19.25 | 10.77 | 47 | 110400 | 11657 | 79622284 |
Schizoaffective disorder | 19.18 | 10.77 | 19 | 110428 | 2133 | 79631808 |
Pulmonary hypertension | 19.15 | 10.77 | 23 | 110424 | 48057 | 79585884 |
Cerebral infarction | 19.11 | 10.77 | 21 | 110426 | 45655 | 79588286 |
Blood thyroid stimulating hormone normal | 19.07 | 10.77 | 7 | 110440 | 118 | 79633823 |
Ureterolithiasis | 18.97 | 10.77 | 25 | 110422 | 3823 | 79630118 |
Blood pressure increased | 18.97 | 10.77 | 194 | 110253 | 211166 | 79422775 |
Personality disorder | 18.89 | 10.77 | 32 | 110415 | 6114 | 79627827 |
Blood bilirubin decreased | 18.86 | 10.77 | 14 | 110433 | 1061 | 79632880 |
Bacteraemia | 18.86 | 10.77 | 11 | 110436 | 32813 | 79601128 |
Respiratory failure | 18.84 | 10.77 | 160 | 110287 | 180751 | 79453190 |
Product physical issue | 18.82 | 10.77 | 26 | 110421 | 4159 | 79629782 |
Calculus urinary | 18.81 | 10.77 | 20 | 110427 | 2440 | 79631501 |
Gastrooesophageal reflux disease | 18.79 | 10.77 | 224 | 110223 | 104022 | 79529919 |
Toxic skin eruption | 18.71 | 10.77 | 4 | 110443 | 22289 | 79611652 |
Premature ejaculation | 18.68 | 10.77 | 6 | 110441 | 66 | 79633875 |
Dyskinesia | 18.67 | 10.77 | 116 | 110331 | 44657 | 79589284 |
Cholestasis | 18.63 | 10.77 | 27 | 110420 | 52082 | 79581859 |
Therapeutic response changed | 18.59 | 10.77 | 15 | 110432 | 1286 | 79632655 |
Dysmorphism | 18.57 | 10.77 | 11 | 110436 | 570 | 79633371 |
Incoherent | 18.49 | 10.77 | 36 | 110411 | 7656 | 79626285 |
International normalised ratio increased | 18.49 | 10.77 | 58 | 110389 | 84663 | 79549278 |
Open angle glaucoma | 18.44 | 10.77 | 10 | 110437 | 437 | 79633504 |
Aspartate aminotransferase decreased | 18.39 | 10.77 | 14 | 110433 | 1103 | 79632838 |
Borderline personality disorder | 18.38 | 10.77 | 13 | 110434 | 914 | 79633027 |
Angina pectoris | 18.31 | 10.77 | 27 | 110420 | 51705 | 79582236 |
Thrombotic microangiopathy | 18.24 | 10.77 | 3 | 110444 | 20166 | 79613775 |
Angular cheilitis | 18.23 | 10.77 | 12 | 110435 | 750 | 79633191 |
Decreased interest | 18.20 | 10.77 | 24 | 110423 | 3673 | 79630268 |
Hepatic function abnormal | 18.20 | 10.77 | 47 | 110400 | 73060 | 79560881 |
Dissociation | 18.11 | 10.77 | 25 | 110422 | 3996 | 79629945 |
Hypopyon | 18.11 | 10.77 | 14 | 110433 | 1128 | 79632813 |
Transferrin saturation decreased | 18.07 | 10.77 | 14 | 110433 | 1132 | 79632809 |
Hereditary angioedema | 18.04 | 10.77 | 29 | 110418 | 5306 | 79628635 |
Restless legs syndrome | 17.98 | 10.77 | 65 | 110382 | 20027 | 79613914 |
Tardive dyskinesia | 17.97 | 10.77 | 43 | 110404 | 10528 | 79623413 |
Urine calcium/creatinine ratio increased | 17.92 | 10.77 | 7 | 110440 | 141 | 79633800 |
Benzodiazepine drug level increased | 17.91 | 10.77 | 8 | 110439 | 228 | 79633713 |
Small for dates baby | 17.85 | 10.77 | 10 | 110437 | 466 | 79633475 |
Illogical thinking | 17.85 | 10.77 | 6 | 110441 | 77 | 79633864 |
Enuresis | 17.81 | 10.77 | 22 | 110425 | 3154 | 79630787 |
Organic brain syndrome | 17.70 | 10.77 | 10 | 110437 | 474 | 79633467 |
Multiple organ dysfunction syndrome | 17.68 | 10.77 | 96 | 110351 | 120150 | 79513791 |
Blood pressure fluctuation | 17.62 | 10.77 | 42 | 110405 | 67103 | 79566838 |
Foetal exposure during pregnancy | 17.60 | 10.77 | 30 | 110417 | 5760 | 79628181 |
Idiopathic intracranial hypertension | 17.56 | 10.77 | 22 | 110425 | 3200 | 79630741 |
Metastases to bone | 17.46 | 10.77 | 6 | 110441 | 24421 | 79609520 |
Poor quality sleep | 17.44 | 10.77 | 70 | 110377 | 22652 | 79611289 |
Vestibular migraine | 17.39 | 10.77 | 7 | 110440 | 153 | 79633788 |
Hippocampal sclerosis | 17.35 | 10.77 | 7 | 110440 | 154 | 79633787 |
Anterior chamber disorder | 17.31 | 10.77 | 7 | 110440 | 155 | 79633786 |
Acquired haemophilia | 17.27 | 10.77 | 17 | 110430 | 1894 | 79632047 |
Blood bicarbonate decreased | 17.26 | 10.77 | 28 | 110419 | 5163 | 79628778 |
Central nervous system lesion | 17.21 | 10.77 | 49 | 110398 | 13319 | 79620622 |
Brain oedema | 17.18 | 10.77 | 75 | 110372 | 25188 | 79608753 |
Glycosuria | 17.10 | 10.77 | 18 | 110429 | 2170 | 79631771 |
Hemiparesis | 17.07 | 10.77 | 92 | 110355 | 33641 | 79600300 |
Blood pressure diastolic abnormal | 17.05 | 10.77 | 3 | 110444 | 19199 | 79614742 |
Basal cell carcinoma | 16.99 | 10.77 | 16 | 110431 | 37359 | 79596582 |
Appendicitis | 16.91 | 10.77 | 4 | 110443 | 20790 | 79613151 |
Drug level decreased | 16.83 | 10.77 | 51 | 110396 | 14351 | 79619590 |
Endometriosis | 16.82 | 10.77 | 23 | 110424 | 3645 | 79630296 |
Rectal haemorrhage | 16.81 | 10.77 | 52 | 110395 | 76248 | 79557693 |
Ischaemic gastritis | 16.81 | 10.77 | 4 | 110443 | 12 | 79633929 |
Perseveration | 16.71 | 10.77 | 9 | 110438 | 388 | 79633553 |
Blood lactic acid increased | 16.69 | 10.77 | 47 | 110400 | 12697 | 79621244 |
Hallucination | 16.68 | 10.77 | 187 | 110260 | 85558 | 79548383 |
Gastrointestinal disorder | 16.65 | 10.77 | 100 | 110347 | 122105 | 79511836 |
Anticonvulsant drug level below therapeutic | 16.60 | 10.77 | 13 | 110434 | 1068 | 79632873 |
Laryngeal stenosis | 16.52 | 10.77 | 13 | 110434 | 1075 | 79632866 |
Narrow anterior chamber angle | 16.52 | 10.77 | 7 | 110440 | 175 | 79633766 |
Failed induction of labour | 16.47 | 10.77 | 8 | 110439 | 277 | 79633664 |
Lung neoplasm malignant | 16.42 | 10.77 | 9 | 110438 | 27783 | 79606158 |
Alanine aminotransferase increased | 16.38 | 10.77 | 145 | 110302 | 162425 | 79471516 |
Multiple drug therapy | 16.37 | 10.77 | 24 | 110423 | 4054 | 79629887 |
Educational problem | 16.35 | 10.77 | 9 | 110438 | 405 | 79633536 |
Conjunctival hyperaemia | 16.33 | 10.77 | 25 | 110422 | 4388 | 79629553 |
Communication disorder | 16.32 | 10.77 | 24 | 110423 | 4066 | 79629875 |
Urge incontinence | 16.31 | 10.77 | 13 | 110434 | 1095 | 79632846 |
Eye movement disorder | 16.31 | 10.77 | 35 | 110412 | 7976 | 79625965 |
Essential tremor | 16.27 | 10.77 | 15 | 110432 | 1540 | 79632401 |
Bradykinesia | 16.21 | 10.77 | 35 | 110412 | 8008 | 79625933 |
Ultrasound liver abnormal | 16.16 | 10.77 | 7 | 110440 | 185 | 79633756 |
Heart rate decreased | 16.16 | 10.77 | 47 | 110400 | 70269 | 79563672 |
Aspartate aminotransferase increased | 16.11 | 10.77 | 119 | 110328 | 138522 | 79495419 |
Near drowning | 16.09 | 10.77 | 5 | 110442 | 49 | 79633892 |
Subdural haematoma | 16.08 | 10.77 | 12 | 110435 | 31422 | 79602519 |
Blood chloride increased | 16.05 | 10.77 | 27 | 110420 | 5129 | 79628812 |
Haematuria traumatic | 15.99 | 10.77 | 7 | 110440 | 190 | 79633751 |
Jaundice | 15.97 | 10.77 | 31 | 110416 | 53318 | 79580623 |
Rales | 15.96 | 10.77 | 4 | 110443 | 19997 | 79613944 |
Therapeutic product effective for unapproved indication | 15.88 | 10.77 | 6 | 110441 | 110 | 79633831 |
Periarthritis | 15.86 | 10.77 | 20 | 110427 | 2928 | 79631013 |
Pregnancy with implant contraceptive | 15.83 | 10.77 | 16 | 110431 | 1840 | 79632101 |
Accommodation disorder | 15.74 | 10.77 | 10 | 110437 | 588 | 79633353 |
Hepatic cytolysis | 15.74 | 10.77 | 9 | 110438 | 27142 | 79606799 |
Hypotension | 15.73 | 10.77 | 477 | 109970 | 439840 | 79194101 |
Chills | 15.67 | 10.77 | 144 | 110303 | 160090 | 79473851 |
Poisoning | 15.67 | 10.77 | 73 | 110374 | 25199 | 79608742 |
Orthostatic hypotension | 15.66 | 10.77 | 34 | 110413 | 56130 | 79577811 |
Atrioventricular septal defect | 15.64 | 10.77 | 6 | 110441 | 115 | 79633826 |
Pulmonary arterial hypertension | 15.61 | 10.77 | 10 | 110437 | 28356 | 79605585 |
Asterixis | 15.59 | 10.77 | 19 | 110428 | 2688 | 79631253 |
Nodular rash | 15.57 | 10.77 | 8 | 110439 | 313 | 79633628 |
Magnetic resonance imaging head abnormal | 15.48 | 10.77 | 19 | 110428 | 2707 | 79631234 |
Accidental death | 15.44 | 10.77 | 24 | 110423 | 4267 | 79629674 |
Acute coronary syndrome | 15.44 | 10.77 | 5 | 110442 | 21128 | 79612813 |
Inflammation | 15.41 | 10.77 | 72 | 110375 | 93681 | 79540260 |
Bladder cancer | 15.40 | 10.77 | 4 | 110443 | 19522 | 79614419 |
Sopor | 15.35 | 10.77 | 88 | 110359 | 32922 | 79601019 |
Drug screen positive | 15.34 | 10.77 | 29 | 110418 | 6034 | 79627907 |
Epistaxis | 15.33 | 10.77 | 91 | 110356 | 111424 | 79522517 |
Drug reaction with eosinophilia and systemic symptoms | 15.29 | 10.77 | 146 | 110301 | 64098 | 79569843 |
Ischaemic stroke | 15.27 | 10.77 | 14 | 110433 | 33117 | 79600824 |
Red blood cell sedimentation rate abnormal | 15.24 | 10.77 | 5 | 110442 | 20958 | 79612983 |
Occipital neuralgia | 15.18 | 10.77 | 9 | 110438 | 467 | 79633474 |
Pseudomonas infection | 15.17 | 10.77 | 5 | 110442 | 20898 | 79613043 |
Haematemesis | 15.11 | 10.77 | 31 | 110416 | 52233 | 79581708 |
Toxic epidermal necrolysis | 15.07 | 10.77 | 24 | 110423 | 44557 | 79589384 |
Cerebral vasoconstriction | 15.03 | 10.77 | 14 | 110433 | 1456 | 79632485 |
Osteomyelitis | 15.02 | 10.77 | 14 | 110433 | 32851 | 79601090 |
Cellulitis | 14.99 | 10.77 | 89 | 110358 | 108971 | 79524970 |
Aspergillus infection | 14.97 | 10.77 | 4 | 110443 | 19157 | 79614784 |
Status migrainosus | 14.95 | 10.77 | 5 | 110442 | 63 | 79633878 |
Localised infection | 14.94 | 10.77 | 18 | 110429 | 37557 | 79596384 |
Electrocardiogram QT prolonged | 14.90 | 10.77 | 191 | 110256 | 90195 | 79543746 |
Basilar migraine | 14.88 | 10.77 | 5 | 110442 | 64 | 79633877 |
Tonic clonic movements | 14.87 | 10.77 | 17 | 110430 | 2247 | 79631694 |
Bladder hypertrophy | 14.85 | 10.77 | 10 | 110437 | 649 | 79633292 |
Pleural rub | 14.81 | 10.77 | 5 | 110442 | 65 | 79633876 |
Creatinine renal clearance decreased | 14.78 | 10.77 | 4 | 110443 | 18998 | 79614943 |
Colitis | 14.75 | 10.77 | 52 | 110395 | 73255 | 79560686 |
Transient epileptic amnesia | 14.68 | 10.77 | 3 | 110444 | 3 | 79633938 |
Product dispensing error | 14.60 | 10.77 | 46 | 110401 | 13217 | 79620724 |
Application site discolouration | 14.60 | 10.77 | 11 | 110436 | 853 | 79633088 |
Haemophagocytic lymphohistiocytosis | 14.54 | 10.77 | 6 | 110441 | 21831 | 79612110 |
Iris disorder | 14.44 | 10.77 | 8 | 110439 | 365 | 79633576 |
Productive cough | 14.42 | 10.77 | 68 | 110379 | 88263 | 79545678 |
Gallbladder disorder | 14.38 | 10.77 | 59 | 110388 | 19281 | 79614660 |
Renal injury | 14.28 | 10.77 | 3 | 110444 | 16924 | 79617017 |
Hyporesponsive to stimuli | 14.26 | 10.77 | 16 | 110431 | 2072 | 79631869 |
Catatonia | 14.23 | 10.77 | 35 | 110412 | 8721 | 79625220 |
Lupus pleurisy | 14.21 | 10.77 | 3 | 110444 | 4 | 79633937 |
Emotional disorder | 14.13 | 10.77 | 48 | 110399 | 14339 | 79619602 |
Blood urea increased | 14.05 | 10.77 | 29 | 110418 | 48761 | 79585180 |
Amino acid level increased | 13.95 | 10.77 | 10 | 110437 | 718 | 79633223 |
Chronic obstructive pulmonary disease | 13.80 | 10.77 | 66 | 110381 | 85353 | 79548588 |
Night blindness | 13.79 | 10.77 | 9 | 110438 | 554 | 79633387 |
Ventricular tachycardia | 13.78 | 10.77 | 23 | 110424 | 41912 | 79592029 |
Distractibility | 13.75 | 10.77 | 10 | 110437 | 735 | 79633206 |
Convulsive threshold lowered | 13.71 | 10.77 | 11 | 110436 | 936 | 79633005 |
Cerebral haemorrhage | 13.66 | 10.77 | 38 | 110409 | 57635 | 79576306 |
Blood pressure diastolic decreased | 13.66 | 10.77 | 13 | 110434 | 30203 | 79603738 |
Intracranial hypotension | 13.62 | 10.77 | 8 | 110439 | 408 | 79633533 |
COVID-19 | 13.62 | 10.77 | 146 | 110301 | 157528 | 79476413 |
Postictal psychosis | 13.56 | 10.77 | 6 | 110441 | 167 | 79633774 |
Renal tubular necrosis | 13.54 | 10.77 | 9 | 110438 | 25030 | 79608911 |
Granulomatous dermatitis | 13.53 | 10.77 | 8 | 110439 | 413 | 79633528 |
Anaphylactic shock | 13.52 | 10.77 | 18 | 110429 | 35978 | 79597963 |
Clostridium difficile infection | 13.49 | 10.77 | 24 | 110423 | 42661 | 79591280 |
Diverticulitis | 13.49 | 10.77 | 27 | 110420 | 45909 | 79588032 |
Hyperacusis | 13.45 | 10.77 | 16 | 110431 | 2207 | 79631734 |
Regressive behaviour | 13.43 | 10.77 | 6 | 110441 | 171 | 79633770 |
Homicidal ideation | 13.38 | 10.77 | 20 | 110427 | 3437 | 79630504 |
Optic neuritis | 13.35 | 10.77 | 36 | 110411 | 9484 | 79624457 |
Pre-existing condition improved | 13.33 | 10.77 | 26 | 110421 | 5537 | 79628404 |
Mastoiditis | 13.29 | 10.77 | 14 | 110433 | 1690 | 79632251 |
Blood pressure decreased | 13.23 | 10.77 | 82 | 110365 | 99384 | 79534557 |
Cluster headache | 13.22 | 10.77 | 11 | 110436 | 985 | 79632956 |
Product dose omission issue | 13.17 | 10.77 | 442 | 110005 | 247095 | 79386846 |
Joint range of motion decreased | 13.17 | 10.77 | 16 | 110431 | 33266 | 79600675 |
Self esteem decreased | 13.16 | 10.77 | 11 | 110436 | 991 | 79632950 |
Dysgeusia | 13.15 | 10.77 | 129 | 110318 | 57048 | 79576893 |
Illiteracy | 13.08 | 10.77 | 4 | 110443 | 37 | 79633904 |
Chorioretinal folds | 13.08 | 10.77 | 4 | 110443 | 37 | 79633904 |
Persecutory delusion | 13.07 | 10.77 | 24 | 110423 | 4885 | 79629056 |
Plasmodium falciparum infection | 13.07 | 10.77 | 5 | 110442 | 95 | 79633846 |
Cerebral venous sinus thrombosis | 13.06 | 10.77 | 16 | 110431 | 2275 | 79631666 |
Uveitis | 13.04 | 10.77 | 52 | 110395 | 16778 | 79617163 |
Automatism | 12.99 | 10.77 | 6 | 110441 | 185 | 79633756 |
Low birth weight baby | 12.97 | 10.77 | 9 | 110438 | 614 | 79633327 |
Paranasal cyst | 12.96 | 10.77 | 8 | 110439 | 447 | 79633494 |
Cytopenia | 12.94 | 10.77 | 6 | 110441 | 20377 | 79613564 |
Hyperthermia malignant | 12.94 | 10.77 | 18 | 110429 | 2899 | 79631042 |
Central obesity | 12.90 | 10.77 | 14 | 110433 | 1747 | 79632194 |
Hereditary optic atrophy | 12.89 | 10.77 | 4 | 110443 | 39 | 79633902 |
Hyperaldosteronism | 12.88 | 10.77 | 8 | 110439 | 452 | 79633489 |
Therapy partial responder | 12.88 | 10.77 | 53 | 110394 | 17344 | 79616597 |
Brain injury | 12.73 | 10.77 | 40 | 110407 | 11477 | 79622464 |
Therapeutic product ineffective for unapproved indication | 12.70 | 10.77 | 6 | 110441 | 195 | 79633746 |
Hypercalcaemia | 12.70 | 10.77 | 21 | 110426 | 38409 | 79595532 |
Narcolepsy | 12.67 | 10.77 | 12 | 110435 | 1274 | 79632667 |
Post laminectomy syndrome | 12.64 | 10.77 | 7 | 110440 | 319 | 79633622 |
Tri-iodothyronine free abnormal | 12.62 | 10.77 | 4 | 110443 | 42 | 79633899 |
Developmental regression | 12.62 | 10.77 | 4 | 110443 | 42 | 79633899 |
Alopecia | 12.60 | 10.77 | 235 | 110212 | 231120 | 79402821 |
Slow response to stimuli | 12.49 | 10.77 | 14 | 110433 | 1811 | 79632130 |
Mydriasis | 12.47 | 10.77 | 53 | 110394 | 17590 | 79616351 |
Negativism | 12.44 | 10.77 | 10 | 110437 | 853 | 79633088 |
Psychiatric symptom | 12.38 | 10.77 | 29 | 110418 | 7006 | 79626935 |
Encephalocele | 12.37 | 10.77 | 4 | 110443 | 45 | 79633896 |
COVID-19 pneumonia | 12.36 | 10.77 | 13 | 110434 | 28836 | 79605105 |
Application site burn | 12.32 | 10.77 | 10 | 110437 | 865 | 79633076 |
Intermenstrual bleeding | 12.32 | 10.77 | 26 | 110421 | 5858 | 79628083 |
Cross sensitivity reaction | 12.31 | 10.77 | 20 | 110427 | 3692 | 79630249 |
Hepatocellular injury | 12.31 | 10.77 | 30 | 110417 | 47563 | 79586378 |
Depersonalisation/derealisation disorder | 12.26 | 10.77 | 14 | 110433 | 1848 | 79632093 |
Tinnitus | 12.21 | 10.77 | 104 | 110343 | 44229 | 79589712 |
Acidosis | 12.19 | 10.77 | 57 | 110390 | 19705 | 79614236 |
Bronchiectasis | 12.17 | 10.77 | 8 | 110439 | 22378 | 79611563 |
Presyncope | 12.16 | 10.77 | 24 | 110423 | 41030 | 79592911 |
Blastocystis infection | 12.14 | 10.77 | 4 | 110443 | 48 | 79633893 |
Binge eating | 12.14 | 10.77 | 8 | 110439 | 501 | 79633440 |
Therapeutic product effect decreased | 12.12 | 10.77 | 157 | 110290 | 163706 | 79470235 |
Lymphomatoid papulosis | 12.12 | 10.77 | 7 | 110440 | 346 | 79633595 |
Red blood cell count decreased | 12.11 | 10.77 | 40 | 110407 | 57473 | 79576468 |
Muscle contractions involuntary | 12.10 | 10.77 | 20 | 110427 | 3745 | 79630196 |
Retinal detachment | 12.01 | 10.77 | 34 | 110413 | 9213 | 79624728 |
Vascular headache | 11.99 | 10.77 | 4 | 110443 | 50 | 79633891 |
Hamartoma | 11.94 | 10.77 | 3 | 110444 | 12 | 79633929 |
Suspected suicide | 11.94 | 10.77 | 37 | 110410 | 10539 | 79623402 |
Transplant rejection | 11.92 | 10.77 | 6 | 110441 | 19431 | 79614510 |
Pneumothorax | 11.87 | 10.77 | 13 | 110434 | 28310 | 79605631 |
Musculoskeletal pain | 11.82 | 10.77 | 88 | 110359 | 102266 | 79531675 |
Ischaemic cerebral infarction | 11.78 | 10.77 | 16 | 110431 | 2519 | 79631422 |
Abortion | 11.74 | 10.77 | 12 | 110435 | 1398 | 79632543 |
Hyperbilirubinaemia | 11.74 | 10.77 | 10 | 110437 | 24508 | 79609433 |
Astrocytoma, low grade | 11.71 | 10.77 | 4 | 110443 | 54 | 79633887 |
Head titubation | 11.71 | 10.77 | 10 | 110437 | 928 | 79633013 |
Full blood count abnormal | 11.70 | 10.77 | 24 | 110423 | 40450 | 79593491 |
Photopsia | 11.66 | 10.77 | 24 | 110423 | 5312 | 79628629 |
Euphoric mood | 11.63 | 10.77 | 30 | 110417 | 7696 | 79626245 |
Complication of device removal | 11.63 | 10.77 | 20 | 110427 | 3869 | 79630072 |
Coma acidotic | 11.62 | 10.77 | 5 | 110442 | 130 | 79633811 |
Balance disorder | 11.61 | 10.77 | 197 | 110250 | 98660 | 79535281 |
Ovarian germ cell cancer stage II | 11.51 | 10.77 | 4 | 110443 | 57 | 79633884 |
Coordination abnormal | 11.47 | 10.77 | 51 | 110396 | 17261 | 79616680 |
Lower gastrointestinal haemorrhage | 11.46 | 10.77 | 4 | 110443 | 16121 | 79617820 |
Drug level increased | 11.45 | 10.77 | 94 | 110353 | 39557 | 79594384 |
Parasomnia | 11.43 | 10.77 | 8 | 110439 | 553 | 79633388 |
Eosinophilia | 11.40 | 10.77 | 29 | 110418 | 45316 | 79588625 |
Decreased nasolabial fold | 11.40 | 10.77 | 3 | 110444 | 15 | 79633926 |
Fever neonatal | 11.40 | 10.77 | 3 | 110444 | 15 | 79633926 |
Idiopathic generalised epilepsy | 11.39 | 10.77 | 4 | 110443 | 59 | 79633882 |
Gambling disorder | 11.31 | 10.77 | 14 | 110433 | 2012 | 79631929 |
Lymphoma | 11.30 | 10.77 | 5 | 110442 | 17455 | 79616486 |
Antipsychotic drug level decreased | 11.27 | 10.77 | 11 | 110436 | 1213 | 79632728 |
Myofascial pain syndrome | 11.25 | 10.77 | 14 | 110433 | 2023 | 79631918 |
Osteonecrosis | 11.23 | 10.77 | 16 | 110431 | 31079 | 79602862 |
Cardiomyopathy | 11.21 | 10.77 | 14 | 110433 | 28760 | 79605181 |
Complex regional pain syndrome | 11.19 | 10.77 | 14 | 110433 | 2034 | 79631907 |
Tic | 11.17 | 10.77 | 17 | 110430 | 2969 | 79630972 |
Retinal vein occlusion | 11.15 | 10.77 | 18 | 110429 | 3305 | 79630636 |
Calcinosis | 11.10 | 10.77 | 15 | 110432 | 2350 | 79631591 |
Cortical dysplasia | 11.08 | 10.77 | 3 | 110444 | 17 | 79633924 |
Skull fracture | 11.08 | 10.77 | 13 | 110434 | 1767 | 79632174 |
Loss of libido | 11.07 | 10.77 | 16 | 110431 | 2669 | 79631272 |
Osmotic demyelination syndrome | 11.04 | 10.77 | 12 | 110435 | 1501 | 79632440 |
Serum ferritin decreased | 11.03 | 10.77 | 15 | 110432 | 2365 | 79631576 |
Breast disorder | 11.01 | 10.77 | 14 | 110433 | 2067 | 79631874 |
Snoring | 10.97 | 10.77 | 24 | 110423 | 5542 | 79628399 |
Oral candidiasis | 10.94 | 10.77 | 15 | 110432 | 29613 | 79604328 |
Hypercapnic coma | 10.94 | 10.77 | 7 | 110440 | 417 | 79633524 |
Wrong technique in product usage process | 10.89 | 10.77 | 153 | 110294 | 73722 | 79560219 |
Electrocardiogram T wave abnormal | 10.88 | 10.77 | 19 | 110428 | 3719 | 79630222 |
Colour blindness | 10.85 | 10.77 | 7 | 110440 | 423 | 79633518 |
Compulsive shopping | 10.80 | 10.77 | 9 | 110438 | 807 | 79633134 |
Maternal exposure during pregnancy | 10.78 | 10.77 | 129 | 110318 | 136409 | 79497532 |
Tubulointerstitial nephritis | 10.78 | 10.77 | 23 | 110424 | 38212 | 79595729 |
Embolism | 10.77 | 10.77 | 3 | 110444 | 13979 | 79619962 |
None
Source | Code | Description |
---|---|---|
ATC | A08AA51 | ALIMENTARY TRACT AND METABOLISM ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS Centrally acting antiobesity products |
ATC | N03AX11 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Other antiepileptics |
FDA PE | N0000008486 | Decreased Central Nervous System Disorganized Electrical Activity |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D007004 | Hypoglycemic Agents |
FDA MoA | N0000182140 | Cytochrome P450 2C19 Inhibitors |
FDA MoA | N0000185506 | Cytochrome P450 3A4 Inducers |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:38633 | sodium channel blockers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Lennox-Gastaut syndrome | indication | 230418006 | |
Tonic-clonic epilepsy | indication | 352818000 | DOID:7725 |
Epilepsy characterized by intractable complex partial seizures | indication | 442481002 | |
Simple partial seizure | indication | 117891000119100 | |
Migraine Prevention | indication | ||
Alcoholism | off-label use | 7200002 | |
Essential tremor | off-label use | 609558009 | DOID:4990 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Suicidal thoughts | contraindication | 6471006 | |
Reduced visual acuity | contraindication | 13164000 | |
Mood swings | contraindication | 18963009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Depressive disorder | contraindication | 35489007 | |
Metabolic acidosis | contraindication | 59455009 | |
Diarrhea | contraindication | 62315008 | |
Fatigue | contraindication | 84229001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Paresthesia | contraindication | 91019004 | |
Kidney stone | contraindication | 95570007 | |
Diminished sweating | contraindication | 111980002 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Drowsy | contraindication | 271782001 | |
Pregnancy, function | contraindication | 289908002 | |
Fever | contraindication | 386661006 | |
Impaired cognition | contraindication | 386806002 | |
Memory impairment | contraindication | 386807006 | |
Dizziness | contraindication | 404640003 | |
Concentration Difficulty | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.6 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10314790 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298580 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8663683 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8877248 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8889191 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8992989 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9549940 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9555004 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9622983 | Nov. 16, 2027 | USE OF TROKENDI XR FOR THE TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | TREATMENT OF EPILEPSY |
100MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | TREATMENT OF EPILEPSY |
200MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | TREATMENT OF EPILEPSY |
25MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | TREATMENT OF EPILEPSY |
50MG | TROKENDI XR | SUPERNUS PHARMS | N201635 | Aug. 16, 2013 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8298576 | April 4, 2028 | USE OF TROKENDI XR FOR PROPHYLACTIC TREATMENT OF MIGRAINE |
EQ 11.25MG BASE;69MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8895057 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 11.25MG BASE;69MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9011906 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 15MG BASE;92MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8895057 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 15MG BASE;92MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9011906 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 3.75MG BASE;23MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8895057 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 3.75MG BASE;23MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9011906 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 7.5MG BASE;46MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8895057 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 7.5MG BASE;46MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 9011906 | June 9, 2028 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2 OR BMI >=27 KG/M2 WITH A WEIGHT-RELATED COMORBIDITY, AND PATIENTS AGE 12-17 WITH BMI >=25 KG/M2 IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX) |
EQ 11.25MG BASE;69MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580299 | June 14, 2029 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2, AND PATIENTS AGE 12-17 WITH BMI >=30 KG/M2 AND IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX), EACH HAVING A WEIGHT-RELATED COMORBIDITY |
EQ 15MG BASE;92MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580299 | June 14, 2029 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2, AND PATIENTS AGE 12-17 WITH BMI >=30 KG/M2 AND IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX), EACH HAVING A WEIGHT-RELATED COMORBIDITY |
EQ 3.75MG BASE;23MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580299 | June 14, 2029 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2, AND PATIENTS AGE 12-17 WITH BMI >=30 KG/M2 AND IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX), EACH HAVING A WEIGHT-RELATED COMORBIDITY |
EQ 7.5MG BASE;46MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 8580299 | June 14, 2029 | FOR CHRONIC WEIGHT MANAGEMENT IN ADULTS WITH BMI >=30 KG/M2, AND PATIENTS AGE 12-17 WITH BMI >=30 KG/M2 AND IN THE 95TH PERCENTILE OR GREATER (STANDARDIZED FOR AGE AND SEX), EACH HAVING A WEIGHT-RELATED COMORBIDITY |
100MG | QUDEXY XR | UPSHER SMITH LABS | N205122 | March 11, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10363224 | March 19, 2033 | TREATMENT OF SEIZURES |
150MG | QUDEXY XR | UPSHER SMITH LABS | N205122 | March 11, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10363224 | March 19, 2033 | TREATMENT OF SEIZURES |
200MG | QUDEXY XR | UPSHER SMITH LABS | N205122 | March 11, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10363224 | March 19, 2033 | TREATMENT OF SEIZURES |
25MG | QUDEXY XR | UPSHER SMITH LABS | N205122 | March 11, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10363224 | March 19, 2033 | TREATMENT OF SEIZURES |
50MG | QUDEXY XR | UPSHER SMITH LABS | N205122 | March 11, 2014 | RX | CAPSULE, EXTENDED RELEASE | ORAL | 10363224 | March 19, 2033 | TREATMENT OF SEIZURES |
25MG/ML | EPRONTIA | AZURITY | N214679 | Nov. 5, 2021 | RX | SOLUTION | ORAL | 11433046 | Aug. 21, 2040 | INDICATED AS ADJUNCTIVE THERAPY FOR THE TREATMENT OF PARTIAL-ONSET SEIZURES, PRIMARY GENERALIZED TONIC-CLONIC SEIZURES, AND SEIZURES ASSOCIATED WITH LENNOX-GASTAUT SYNDROME IN PATIENTS 2 YEARS OF AGE AND OLDER |
25MG/ML | EPRONTIA | AZURITY | N214679 | Nov. 5, 2021 | RX | SOLUTION | ORAL | 11433046 | Aug. 21, 2040 | INDICATED AS INITIAL MONOTHERAPY FOR THE TREATMENT OF PARTIAL-ONSET OR PRIMARY GENERALIZED TONIC-CLONIC SEIZURES IN PATIENTS 2 YEARS OF AGE AND OLDER |
25MG/ML | EPRONTIA | AZURITY | N214679 | Nov. 5, 2021 | RX | SOLUTION | ORAL | 11433046 | Aug. 21, 2040 | INDICATED FOR THE PREVENTIVE TREATMENT OF MIGRAINE IN PATIENTS 12 YEARS AND OLDER |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 11.25MG BASE;69MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | June 24, 2025 | NEW PATIENT POPULATION |
EQ 15MG BASE;92MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | June 24, 2025 | NEW PATIENT POPULATION |
EQ 3.75MG BASE;23MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | June 24, 2025 | NEW PATIENT POPULATION |
EQ 7.5MG BASE;46MG | QSYMIA | VIVUS | N022580 | July 17, 2012 | RX | CAPSULE, EXTENDED RELEASE | ORAL | June 24, 2025 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Carbonic anhydrase 4 | Enzyme | INHIBITOR | Ki | 5.31 | CHEMBL | CHEMBL | |||
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE MODULATOR | WOMBAT-PK | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | INHIBITOR | Ki | 8.30 | CHEMBL | CHEMBL | |||
Glutamate receptor ionotropic kainate | Ion channel | ANTAGONIST | CHEMBL | CHEMBL | |||||
Glutamate receptor ionotropic AMPA | Ion channel | ANTAGONIST | CHEMBL | CHEMBL | |||||
Sodium channel protein type 1 subunit alpha | Ion channel | BLOCKER | DRUGBANK | CHEMBL | |||||
Sodium channel protein type 5 subunit alpha | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 9.06 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 7.35 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.84 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 7.33 | CHEMBL | |||||
Carbonic anhydrase V | Enzyme | Ki | 7.60 | CHEMBL | |||||
Nuclear receptor subfamily 1 group I member 2 | Nuclear hormone receptor | WOMBAT-PK | |||||||
Carbonic anhydrase 1 | Enzyme | Ki | 6.60 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 7.24 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 8.42 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Kd | 7.60 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 7.52 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 6.76 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 7.33 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 7.27 | CHEMBL | |||||
Sodium channel protein type 2 subunit alpha | Ion channel | IC50 | 4.01 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | IC50 | 5.85 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 6.92 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 4.63 | CHEMBL | |||||
Carbonic anhydrase 15 | Enzyme | Ki | 7.11 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 6.96 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 8 | CHEMBL | |||||
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase | Enzyme | Ki | 5.52 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 6.96 | CHEMBL | |||||
Alpha carbonic anhydrase | Enzyme | Ki | 7.54 | CHEMBL | |||||
Carbonic anhydrase | Enzyme | Ki | 6.44 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 6.43 | CHEMBL | |||||
Astrosclerin-3 | Enzyme | Ki | 7.42 | CHEMBL | |||||
Beta-carbonic anhydrase 1 | Enzyme | Ki | 6.21 | CHEMBL | |||||
Delta carbonic anhydrase | Unclassified | Ki | 6.41 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 6.32 | CHEMBL | |||||
Carbonic anhydrase, alpha family | Unclassified | Ki | 6.11 | CHEMBL | |||||
Carbonate dehydratase | Enzyme | Ki | 8.18 | CHEMBL |
ID | Source |
---|---|
4021026 | VUID |
N0000148493 | NUI |
D00537 | KEGG_DRUG |
4021026 | VANDF |
C0076829 | UMLSCUI |
CHEBI:63631 | CHEBI |
TOR | PDB_CHEM_ID |
CHEMBL220492 | ChEMBL_ID |
DB00273 | DRUGBANK_ID |
D000077236 | MESH_DESCRIPTOR_UI |
5284627 | PUBCHEM_CID |
6849 | IUPHAR_LIGAND_ID |
6099 | INN_ID |
0H73WJJ391 | UNII |
220343 | RXNORM |
162273 | MMSL |
5601 | MMSL |
6438 | MMSL |
d04115 | MMSL |
005453 | NDDF |
108400009 | SNOMEDCT_US |
386844006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7335 | CAPSULE, COATED PELLETS | 15 mg | ORAL | ANDA | 29 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7335 | CAPSULE, COATED PELLETS | 15 mg | ORAL | ANDA | 29 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7336 | CAPSULE, COATED PELLETS | 25 mg | ORAL | ANDA | 29 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7336 | CAPSULE, COATED PELLETS | 25 mg | ORAL | ANDA | 29 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1071 | CAPSULE, EXTENDED RELEASE | 25 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1071 | CAPSULE, EXTENDED RELEASE | 25 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1072 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1072 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1073 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1073 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1074 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1074 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1075 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | NDA | 30 sections |
QUDEXY XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0245-1075 | CAPSULE, EXTENDED RELEASE | 150 mg | ORAL | NDA | 30 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-2356 | CAPSULE, EXTENDED RELEASE | 25 mg | ORAL | ANDA | 27 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-2357 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 27 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-2358 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 27 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0480-2359 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 27 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7562 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7563 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7564 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7565 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8138 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8138 | TABLET, FILM COATED | 25 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8139 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8139 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8140 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8140 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 28 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1071 | CAPSULE, EXTENDED RELEASE | 25 mg | ORAL | NDA authorized generic | 32 sections |
Topiramate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1071 | CAPSULE, EXTENDED RELEASE | 25 mg | ORAL | NDA authorized generic | 32 sections |