tolperisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2703	728-88-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tolperisone
mideton
mydeton
mydetone
dl-Tolperisone
tolperisone hydrochloride
(+/-)-Tolperisone
tolperisone HCl

A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)

Molecular weight: 245.37
Formula: C16H23NO
CLOGP: 3.83
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 20.31
ALOGS: -3.17
ROTB: 4

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory alkalosis	52.45	29.93	11	805	2690	63485516
Serotonin syndrome	48.67	29.93	17	799	28665	63459541

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Respiratory alkalosis	46.36	34.10	10	657	4301	79739420
Serotonin syndrome	44.55	34.10	16	651	45011	79698710

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M02AX06	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Other topical products for joint and muscular pain
ATC	M03BX04	MUSCULO-SKELETAL SYSTEM MUSCLE RELAXANTS MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS Other centrally acting agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Spasticity	indication	221360009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.68	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	8.25		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.34		DRUG MATRIX
SMR1-alpha3	Unclassified		P70634_RAT		Ki	5.69		DRUG MATRIX
BetaB2-crystallin	Unclassified		P70635_RAT		IC50	5.47		DRUG MATRIX

External reference:

ID	Source
F5EOM0LD8E	UNII
N0000167236	NUI
D01507	KEGG_DRUG
3644-61-9	SECONDARY_CAS_RN
C0040382	UMLSCUI
CHEBI:93835	CHEBI
CHEMBL1076211	ChEMBL_ID
5511	PUBCHEM_CID
DB06264	DRUGBANK_ID
CHEMBL1395150	ChEMBL_ID
D014049	MESH_DESCRIPTOR_UI
3298	INN_ID
10639	RXNORM
004185	NDDF
004186	NDDF
1172426007	SNOMEDCT_US
703717006	SNOMEDCT_US
703718001	SNOMEDCT_US

Pharmaceutical products:

None