DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
toloxatone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
2702
29218-27-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
humoryl
toloxatone
taloxotone
oxazolidinone derivative; psychotropic drug; structure
Molecular weight: 207.23
Formula: C11H13NO3
CLOGP: 1.48
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 49.77
ALOGS: -0.58
ROTB: 2
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
56 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
11 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
1.60 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
1.50 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.49 %
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Phaeochromocytoma
30.99
24.60
3
3
516
63488500
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Phaeochromocytoma
30.92
22.86
3
3
664
79743718
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N06AG03
NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase A inhibitors
CHEBI has role
CHEBI:35469
antidepressants
CHEBI has role
CHEBI:38623
monoamine oxidase inhibitors
MeSH PA
D000928
Antidepressive Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D008996
Monoamine Oxidase Inhibitors
MeSH PA
D011619
Psychotropic Drugs
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Depressive disorder
indication
35489007
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
11.77
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Amine oxidase [flavin-containing] A
Enzyme
P21397
AOFA_HUMAN
INHIBITOR
Ki
5.82
CHEMBL
SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] B
Enzyme
P27338
AOFB_HUMAN
Ki
4.82
CHEMBL
Amine oxidase [flavin-containing] A
Enzyme
AOFA_RAT
Ki
6.42
CHEMBL
Amine oxidase [flavin-containing] A
Enzyme
AOFA_BOVIN
Ki
6.42
CHEMBL
Amine oxidase [flavin-containing] B
Enzyme
AOFB_BOVIN
Ki
4.82
CHEMBL
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External reference:
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ID
Source
005364
NDDF
3429
INN_ID
34521
PUBCHEM_CID
38382
RXNORM
5T206015T5
UNII
C0076804
UMLSCUI
C010798
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:134870
CHEBI
CHEMBL18116
ChEMBL_ID
D02559
KEGG_DRUG
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Pharmaceutical products:
None
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toloxatone