tolonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 2701 | 92-31-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A phenothiazine that has been used as a hemostatic, a biological stain, and a dye for wool and silk. Tolonium chloride has also been used as a diagnostic aid for oral and gastric neoplasms and in the identification of the parathyroid gland in thyroid surgery.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D003029 | Coagulants |
| MeSH PA | D004396 | Coloring Agents |
| MeSH PA | D006401 | Hematologic Agents |
| MeSH PA | D006490 | Hemostatics |
| MeSH PA | D006494 | Heparin Antagonists |
| CHEBI has role | CHEBI:33295 | diagnostic aid |
| CHEBI has role | CHEBI:51217 | fluorochromes |
| CHEBI has role | CHEBI:77178 | biological stain |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.51 | Basic |
| pKa2 | 3.89 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Microtubule-associated protein tau | Structural | Ki | 7.16 | CHEMBL | |||||
| Zinc finger protein mex-5 | Cytosolic other | EC50 | 4.45 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167280 | NUI |
| 3209-30-1 | SECONDARY_CAS_RN |
| 4040795 | VANDF |
| C0040380 | UMLSCUI |
| CHEBI:87647 | CHEBI |
| CHEMBL1197206 | ChEMBL_ID |
| CHEMBL1622638 | ChEMBL_ID |
| CHEMBL1790006 | ChEMBL_ID |
| 7084 | PUBCHEM_CID |
| P3Y6XJA2D1 | UNII |
| 10638 | RXNORM |
| NOCODE | MMSL |
| 002095 | NDDF |
| 29522004 | SNOMEDCT_US |
| 417083005 | SNOMEDCT_US |
| D014048 | MESH_DESCRIPTOR_UI |
| 231 | INN_ID |
| 56109-24-1 | SECONDARY_CAS_RN |
Pharmaceutical products:
None