fluorouracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
uracil type antineoplastics 26 51-21-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 5-fluorouracil
  • adrucil
  • fluoroblastin
  • fluorouracil
  • 5-FU
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
  • Molecular weight: 130.08
  • Formula: C4H3FN2O2
  • CLOGP: -0.58
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.20
  • ALOGS: -1.35
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 92.25 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 28 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.23 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 26 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.64 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.12 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 25, 1962 FDA SPECTRUM PHARMS
Sept. 21, 2018 PMDA Kyowa Hakko Kirin Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 2100.75 13.66 1770 80901 173235 63233116
Febrile neutropenia 1119.22 13.66 1048 81623 117401 63288950
Mucosal inflammation 1072.96 13.66 701 81970 46227 63360124
Neuropathy peripheral 1043.75 13.66 990 81681 112677 63293674
Diarrhoea 778.91 13.66 2361 80310 713005 62693346
Disease progression 756.74 13.66 864 81807 121894 63284457
Thrombocytopenia 654.19 13.66 891 81780 150266 63256085
Palmar-plantar erythrodysaesthesia syndrome 595.65 13.66 372 82299 22643 63383708
Leukopenia 589.56 13.66 609 82062 76681 63329670
Neurotoxicity 581.81 13.66 329 82342 16661 63389690
Malignant neoplasm progression 546.71 13.66 602 82069 81519 63324832
Dermatitis acneiform 515.99 13.66 207 82464 4789 63401562
Skin toxicity 489.22 13.66 196 82475 4518 63401833
Metastases to liver 439.57 13.66 311 82360 23328 63383023
Vomiting 420.86 13.66 1636 81035 557981 62848370
Bone marrow failure 363.53 13.66 303 82368 28987 63377364
Nausea 316.47 13.66 2043 80628 852428 62553923
Rheumatoid arthritis 305.19 13.66 5 82666 253814 63152537
Neoplasm progression 303.00 13.66 301 82370 36127 63370224
Metastases to lung 302.17 13.66 195 82476 12555 63393796
Drug ineffective 301.05 13.66 567 82104 1044198 62362153
Acute myeloid leukaemia 299.03 13.66 217 82454 16930 63389421
Joint swelling 297.68 13.66 38 82633 327628 63078723
Arteriospasm coronary 288.11 13.66 128 82543 3840 63402511
Cardiotoxicity 269 13.66 156 82515 8282 63398069
Paronychia 261.35 13.66 133 82538 5432 63400919
Neutrophil count decreased 259.50 13.66 343 82328 56063 63350288
Metastases to bone 255.74 13.66 215 82456 20804 63385547
Polyneuropathy 255.24 13.66 185 82486 14404 63391947
Arthralgia 253.65 13.66 222 82449 569488 62836863
Stomatitis 251.72 13.66 557 82114 138168 63268183
Abdominal discomfort 246.09 13.66 58 82613 320827 63085524
Systemic lupus erythematosus 243.58 13.66 6 82665 208912 63197439
Myelosuppression 229.52 13.66 213 82458 23490 63382861
Metastasis 223.30 13.66 117 82554 5080 63401271
Peripheral sensory neuropathy 217.16 13.66 130 82541 7321 63399030
Haematotoxicity 216.28 13.66 141 82530 9235 63397116
Product dose omission issue 215.55 13.66 26 82645 234287 63172064
Gastrointestinal toxicity 215.14 13.66 131 82540 7610 63398741
Contraindicated product administered 213.48 13.66 19 82652 217629 63188722
Posterior reversible encephalopathy syndrome 210.15 13.66 177 82494 17168 63389183
Swelling 206.74 13.66 52 82619 275326 63131025
Anaemia 205.08 13.66 840 81831 292590 63113761
Arthropathy 204.24 13.66 31 82640 234761 63171590
Gastrointestinal perforation 201.41 13.66 96 82575 3395 63402956
Pemphigus 201.03 13.66 9 82662 183717 63222634
Interstitial lung disease 200.75 13.66 319 82352 61589 63344762
Pain 194.58 13.66 423 82248 740205 62666146
Ejection fraction decreased 192.12 13.66 188 82483 22144 63384207
Cardiomyopathy 191.84 13.66 169 82502 17415 63388936
Therapeutic product effect decreased 191.81 13.66 16 82655 193171 63213180
Second primary malignancy 189.34 13.66 122 82549 7831 63398520
Hyperammonaemia 183.61 13.66 103 82568 5129 63401222
Acute promyelocytic leukaemia 183.44 13.66 62 82609 865 63405486
Wound 181.95 13.66 7 82664 163256 63243095
Laryngospasm 180.00 13.66 85 82586 2943 63403408
Sinusitis 179.64 13.66 38 82633 226615 63179736
Pulmonary embolism 178.17 13.66 438 82233 116246 63290105
Glossodynia 177.07 13.66 15 82656 178861 63227490
Weight increased 169.24 13.66 64 82607 260728 63145623
Dehydration 165.29 13.66 549 82122 172805 63233546
Product use issue 160.97 13.66 44 82627 220476 63185875
Nasopharyngitis 160.69 13.66 65 82606 254192 63152159
Decreased appetite 159.98 13.66 699 81972 250353 63155998
Pyrexia 159.10 13.66 1102 81569 469376 62936975
Hypokalaemia 157.76 13.66 389 82282 103415 63302936
Abdominal pain 157.51 13.66 777 81894 292679 63113672
Headache 147.52 13.66 385 82286 632856 62773495
Asthenia 147.44 13.66 928 81743 382676 63023675
Disease recurrence 147.05 13.66 182 82489 27848 63378503
Fall 146.93 13.66 177 82494 392157 63014194
Metastases to lymph nodes 146.23 13.66 105 82566 8053 63398298
Paraesthesia 139.83 13.66 486 82185 156480 63249871
Peripheral swelling 139.52 13.66 87 82584 265855 63140496
Large intestine perforation 131.42 13.66 100 82571 8382 63397969
Musculoskeletal stiffness 130.71 13.66 39 82632 184579 63221772
Drug hypersensitivity 129.72 13.66 128 82543 310559 63095792
Neutropenic sepsis 129.61 13.66 132 82539 16306 63390045
Hypomagnesaemia 126.36 13.66 171 82500 28566 63377785
Portal hypertension 125.43 13.66 72 82599 3747 63402604
Discomfort 124.76 13.66 32 82639 167342 63239009
Therapy partial responder 123.44 13.66 106 82565 10552 63395799
Non-cirrhotic portal hypertension 120.95 13.66 33 82638 208 63406143
Pain in extremity 120.43 13.66 153 82518 331333 63075018
Enteritis 120.32 13.66 94 82577 8192 63398159
General physical health deterioration 117.87 13.66 547 82124 200855 63205496
Colorectal cancer metastatic 117.38 13.66 40 82631 573 63405778
Proteinuria 114.68 13.66 133 82538 19012 63387339
Hepatic enzyme increased 110.56 13.66 63 82608 202265 63204086
Contusion 109.33 13.66 30 82641 150014 63256337
Injection site pain 108.63 13.66 19 82652 129781 63276570
Maternal exposure during pregnancy 107.32 13.66 78 82593 219984 63186367
Helicobacter infection 106.82 13.66 3 82668 92782 63313569
Neutropenic colitis 106.08 13.66 60 82611 3035 63403316
Ascites 105.61 13.66 190 82481 40538 63365813
Hyperammonaemic encephalopathy 105.14 13.66 55 82616 2379 63403972
Death 103.68 13.66 837 81834 373544 63032807
Psoriatic arthropathy 101.67 13.66 4 82667 91516 63314835
Ileus 99.64 13.66 109 82562 14616 63391735
Stress cardiomyopathy 97.46 13.66 88 82583 9362 63396989
Pericarditis 96.44 13.66 26 82645 131553 63274798
Intestinal perforation 96.02 13.66 97 82574 11866 63394485
Depression 95.34 13.66 70 82601 196422 63209929
Hypertransaminasaemia 93.85 13.66 74 82597 6535 63399816
Condition aggravated 93.08 13.66 245 82426 401972 63004379
Mobility decreased 92.54 13.66 22 82649 121137 63285214
Duodenal ulcer perforation 89.98 13.66 6 82665 87203 63319148
Migraine 86.75 13.66 15 82656 103331 63303020
Drug intolerance 85.11 13.66 171 82500 308490 63097861
Left ventricular dysfunction 85.07 13.66 91 82580 11897 63394454
Arthritis 84.77 13.66 23 82648 115898 63290453
Treatment failure 84.16 13.66 81 82590 198962 63207389
Psoriasis 84.10 13.66 8 82663 86949 63319402
Extravasation 84.05 13.66 47 82624 2325 63404026
Cardiac failure 82.79 13.66 280 82391 88862 63317489
Focal nodular hyperplasia 81.68 13.66 30 82641 541 63405810
Pruritus 81.46 13.66 223 82448 361230 63045121
Pancytopenia 80.98 13.66 294 82377 96639 63309712
Influenza 80.59 13.66 21 82650 108701 63297650
Dysarthria 80.16 13.66 174 82497 42537 63363814
Oesophageal fistula 79.15 13.66 22 82649 150 63406201
Breast cancer metastatic 77.93 13.66 87 82584 11931 63394420
Drug abuse 77.83 13.66 4 82667 72514 63333837
Lower respiratory tract infection 76.95 13.66 38 82633 132269 63274082
Hospitalisation 76.80 13.66 10 82661 85071 63321280
Device related thrombosis 76.15 13.66 40 82631 1745 63404606
Osteoarthritis 75.44 13.66 16 82655 95327 63311024
Loss of personal independence in daily activities 73.63 13.66 18 82653 97272 63309079
Intestinal obstruction 73.62 13.66 139 82532 30760 63375591
Anxiety 72.28 13.66 107 82564 217434 63188917
Peritonitis 72.27 13.66 100 82571 17054 63389297
Injection site erythema 72.20 13.66 11 82660 83163 63323188
Cholangitis 69.94 13.66 58 82613 5503 63400848
Bronchitis 69.52 13.66 38 82633 124897 63281454
Haemolytic anaemia 68.59 13.66 75 82596 10050 63396301
Metastases to peritoneum 67.95 13.66 47 82624 3395 63402956
Injury 67.60 13.66 8 82663 73239 63333112
Deep vein thrombosis 67.33 13.66 251 82420 83549 63322802
Blister 67.27 13.66 43 82628 129771 63276580
Type 2 diabetes mellitus 67.06 13.66 4 82667 63864 63342487
Congestive cardiomyopathy 64.60 13.66 58 82613 6124 63400227
Enterocutaneous fistula 64.47 13.66 33 82638 1364 63404987
Rash pustular 63.92 13.66 62 82609 7220 63399131
COVID-19 63.51 13.66 34 82637 113069 63293282
Intentional product misuse 63.41 13.66 4 82667 60913 63345438
Colitis 62.49 13.66 171 82500 48357 63357994
Sleep disorder 61.90 13.66 15 82656 81551 63324800
Metastases to skin 61.80 13.66 34 82637 1629 63404722
Leukoencephalopathy 61.78 13.66 49 82622 4364 63401987
Intentional product use issue 61.44 13.66 46 82625 127846 63278505
White blood cell count decreased 61.19 13.66 349 82322 138755 63267596
Suicidal ideation 59.68 13.66 6 82665 62415 63343936
Insomnia 59.50 13.66 119 82552 215133 63191218
Wheezing 59.41 13.66 25 82646 95570 63310781
Rectal perforation 58.59 13.66 22 82649 423 63405928
Dihydropyrimidine dehydrogenase deficiency 58.58 13.66 15 82656 71 63406280
Metastases to ovary 57.97 13.66 22 82649 436 63405915
Pneumonia 57.96 13.66 353 82318 456414 62949937
Trichomegaly 57.90 13.66 15 82656 75 63406276
Splenomegaly 57.79 13.66 72 82599 11085 63395266
Chills 57.67 13.66 296 82375 113082 63293269
Troponin I increased 57.42 13.66 36 82635 2202 63404149
Colony stimulating factor therapy 57.42 13.66 20 82651 307 63406044
Gastrointestinal necrosis 57.11 13.66 39 82632 2759 63403592
Hyperbilirubinaemia 56.99 13.66 72 82599 11242 63395109
Immune thrombocytopenia 56.09 13.66 69 82602 10487 63395864
Adverse drug reaction 56.09 13.66 17 82654 79697 63326654
Disseminated intravascular coagulation 56.06 13.66 94 82577 18957 63387394
Dizziness 55.20 13.66 331 82340 429594 62976757
Ocular toxicity 55.09 13.66 24 82647 686 63405665
Chronic obstructive pulmonary disease 55.08 13.66 8 82663 62678 63343673
Mucosal toxicity 54.54 13.66 20 82651 359 63405992
Breast cancer recurrent 54.02 13.66 45 82626 4296 63402055
Haemolytic uraemic syndrome 53.74 13.66 36 82635 2467 63403884
Urticaria 53.66 13.66 83 82588 165719 63240632
Tumour perforation 53.62 13.66 15 82656 105 63406246
Thrombocytopenic purpura 53.24 13.66 29 82642 1362 63404989
Suicide attempt 53.00 13.66 8 82663 60910 63345441
Metastases to pleura 52.37 13.66 30 82641 1555 63404796
Septic shock 52.21 13.66 198 82473 66431 63339920
Carcinoembryonic antigen increased 51.96 13.66 31 82640 1734 63404617
Cholinergic syndrome 51.88 13.66 21 82650 497 63405854
Asthma 51.50 13.66 54 82617 127507 63278844
Memory impairment 50.72 13.66 37 82634 104221 63302130
Large intestinal obstruction 48.94 13.66 33 82638 2286 63404065
Nodular regenerative hyperplasia 48.92 13.66 20 82651 486 63405865
Sepsis 48.75 13.66 354 82317 152769 63253582
Feeling abnormal 48.29 13.66 74 82597 148318 63258033
Aortitis 48.21 13.66 25 82646 1062 63405289
Confusional state 48.00 13.66 153 82518 236227 63170124
Stress 47.84 13.66 14 82657 67153 63339198
Febrile bone marrow aplasia 47.44 13.66 53 82618 7272 63399079
Subacute cutaneous lupus erythematosus 47.32 13.66 34 82637 2609 63403742
Hyperthermia 47.28 13.66 59 82612 9097 63397254
Fluid retention 47.24 13.66 10 82661 59676 63346675
Myelodysplastic syndrome 47.09 13.66 81 82590 16673 63389678
Drug interaction 46.74 13.66 148 82523 228983 63177368
Injection site reaction 45.92 13.66 10 82661 58514 63347837
Metastases to central nervous system 45.89 13.66 70 82601 13035 63393316
Embolism 45.80 13.66 54 82617 7852 63398499
Agranulocytosis 45.57 13.66 101 82570 25033 63381318
Dysgeusia 45.37 13.66 149 82522 46561 63359790
Epistaxis 44.29 13.66 200 82471 72525 63333826
Malignant respiratory tract neoplasm 44.25 13.66 11 82660 45 63406306
Red blood cell sedimentation rate increased 42.64 13.66 4 82667 43978 63362373
Administration site extravasation 42.24 13.66 22 82649 943 63405408
Injection site swelling 41.96 13.66 6 82665 47566 63358785
Acute coronary syndrome 41.12 13.66 58 82613 10068 63396283
Hypophagia 41.09 13.66 111 82560 31148 63375203
Nasal congestion 41.07 13.66 17 82654 65643 63340708
Hormone receptor positive breast cancer 40.94 13.66 18 82653 526 63405825
Osteonecrosis of jaw 40.56 13.66 119 82552 35004 63371347
Gait disturbance 40.45 13.66 114 82557 183064 63223287
Myocarditis 40.25 13.66 58 82613 10267 63396084
Incorrect dose administered 40.05 13.66 14 82657 59954 63346397
Adverse event 39.88 13.66 19 82652 67540 63338811
Aortic thrombosis 39.55 13.66 22 82649 1077 63405274
Dysentery 39.48 13.66 21 82650 940 63405411
Splenic artery thrombosis 39.11 13.66 10 82661 47 63406304
Factor VII deficiency 38.88 13.66 9 82662 25 63406326
Short-bowel syndrome 38.85 13.66 17 82654 491 63405860
Aplasia 38.77 13.66 37 82634 4222 63402129
Cataract 38.65 13.66 13 82658 57040 63349311
Steatohepatitis 38.12 13.66 18 82653 623 63405728
Dermatitis 37.59 13.66 74 82597 16884 63389467
Rash 37.49 13.66 510 82161 560361 62845990
Skin fissures 37.32 13.66 59 82612 11329 63395022
Hydrothorax 37.28 13.66 20 82651 911 63405440
Overdose 36.85 13.66 58 82613 115020 63291331
Stridor 36.81 13.66 33 82638 3477 63402874
Venous pressure jugular decreased 36.57 13.66 9 82662 35 63406316
Encephalopathy 36.44 13.66 122 82549 38498 63367853
Sedation 36.40 13.66 4 82667 38805 63367546
Pharyngeal dyskinesia 36.37 13.66 9 82662 36 63406315
Xerosis 36.28 13.66 20 82651 962 63405389
Jugular vein thrombosis 36.08 13.66 31 82640 3087 63403264
Balance disorder 36.07 13.66 34 82637 84388 63321963
Device related infection 35.84 13.66 88 82583 23304 63383047
Hepatic failure 35.76 13.66 115 82556 35541 63370810
Cystitis radiation 35.75 13.66 10 82661 70 63406281
Bladder tamponade 35.63 13.66 10 82661 71 63406280
Subileus 35.56 13.66 31 82640 3148 63403203
Hypertensive crisis 35.46 13.66 68 82603 15218 63391133
Folliculitis 35.45 13.66 24 82647 70293 63336058
Subclavian vein thrombosis 35.42 13.66 25 82646 1865 63404486
Toxic leukoencephalopathy 35.41 13.66 18 82653 733 63405618
Heart rate decreased 35.31 13.66 8 82663 45552 63360799
Abortion spontaneous 35.18 13.66 9 82662 47186 63359165
White blood cell count abnormal 35.11 13.66 42 82629 6200 63400151
Somnolence 34.64 13.66 118 82553 178567 63227784
Proctalgia 34.19 13.66 41 82630 6069 63400282
Miller Fisher syndrome 33.95 13.66 10 82661 86 63406265
Upper respiratory tract infection 33.94 13.66 34 82637 82013 63324338
Tumour ulceration 33.77 13.66 12 82659 196 63406155
Dysaesthesia 33.56 13.66 35 82636 4443 63401908
Illness 33.55 13.66 11 82660 49048 63357303
Pleural effusion 33.48 13.66 222 82449 92988 63313363
Nephritis bacterial 33.39 13.66 8 82663 27 63406324
Anastomotic leak 33.39 13.66 15 82656 462 63405889
Ear infection 33.28 13.66 5 82666 38208 63368143
Neuromyotonia 33.22 13.66 9 82662 55 63406296
Gastric varices haemorrhage 33.11 13.66 11 82660 145 63406206
Organising pneumonia 32.72 13.66 39 82632 5737 63400614
Liver abscess 32.27 13.66 28 82643 2826 63403525
Rhabdomyolysis 31.60 13.66 9 82662 43942 63362409
Tumour lysis syndrome 31.45 13.66 48 82623 8942 63397409
Small intestinal obstruction 31.36 13.66 72 82599 18265 63388086
Venoocclusive liver disease 31.34 13.66 35 82636 4800 63401551
Joint range of motion decreased 31.30 13.66 3 82668 32425 63373926
Acute lymphocytic leukaemia 31.14 13.66 26 82645 2490 63403861
Tongue oedema 31.11 13.66 34 82637 4552 63401799
Unevaluable event 31.03 13.66 14 82657 51372 63354979
Venous thrombosis 30.95 13.66 35 82636 4867 63401484
Infusion related hypersensitivity reaction 30.76 13.66 12 82659 257 63406094
Respiratory failure 30.42 13.66 232 82439 101626 63304725
Metastases to meninges 30.37 13.66 26 82645 2576 63403775
Metastases to chest wall 30.27 13.66 15 82656 578 63405773
Portal vein thrombosis 30.13 13.66 26 82645 2604 63403747
Platelet count decreased 30.07 13.66 256 82415 115866 63290485
Atypical haemolytic uraemic syndrome 30.02 13.66 16 82655 719 63405632
Vena cava thrombosis 30.01 13.66 24 82647 2163 63404188
Varices oesophageal 29.90 13.66 28 82643 3120 63403231
Cachexia 29.73 13.66 37 82634 5689 63400662
Metastases to reproductive organ 29.72 13.66 6 82665 6 63406345
Hepatic lesion 29.70 13.66 34 82637 4791 63401560
Adenocarcinoma 29.50 13.66 27 82644 2923 63403428
Wrong technique in product usage process 29.19 13.66 23 82648 62317 63344034
Enterocolitis 28.97 13.66 43 82628 7815 63398536
Gastrooesophageal reflux disease 28.94 13.66 50 82621 95589 63310762
Female genital tract fistula 28.79 13.66 42 82629 7517 63398834
Tumour necrosis 28.40 13.66 16 82655 803 63405548
Night sweats 28.40 13.66 14 82657 48800 63357551
Malignant pleural effusion 28.32 13.66 25 82646 2581 63403770
Gait inability 28.17 13.66 17 82654 52942 63353409
Renal salt-wasting syndrome 27.97 13.66 12 82659 330 63406021
Infusion related reaction 27.90 13.66 196 82475 245325 63161026
Acute interstitial pneumonitis 27.84 13.66 15 82656 689 63405662
Ileal perforation 27.77 13.66 13 82658 441 63405910
Bursitis 27.73 13.66 7 82664 37034 63369317
Nicotinic acid deficiency 27.67 13.66 8 82663 64 63406287
Conjunctival filtering bleb leak 27.64 13.66 6 82665 11 63406340
Acute abdomen 27.63 13.66 20 82651 1553 63404798
Pregnancy 27.50 13.66 7 82664 36829 63369522
ECG signs of myocardial ischaemia 27.45 13.66 8 82663 66 63406285
Blood pressure fluctuation 27.38 13.66 13 82658 46304 63360047
Metastases to spine 27.28 13.66 27 82644 3222 63403129
Road traffic accident 27.28 13.66 7 82664 36625 63369726
Osteonecrosis 27.27 13.66 82 82589 24448 63381903
Dry skin 27.17 13.66 146 82525 56741 63349610
Adenocarcinoma of colon 27.17 13.66 24 82647 2480 63403871
Metastases to the mediastinum 26.88 13.66 13 82658 475 63405876
Emotional distress 26.71 13.66 5 82666 32544 63373807
Multiple organ dysfunction syndrome 26.67 13.66 145 82526 56607 63349744
Left ventricular dilatation 26.55 13.66 13 82658 488 63405863
Throat tightness 26.55 13.66 82 82589 24805 63381546
Therapy cessation 26.49 13.66 4 82667 30453 63375898
Ill-defined disorder 26.36 13.66 41 82630 81714 63324637
Hypocalcaemia 26.30 13.66 96 82575 31617 63374734
Myocardial ischaemia 25.98 13.66 54 82617 12805 63393546
Obesity 25.90 13.66 4 82667 29948 63376403
Inferior vena cava stenosis 25.83 13.66 6 82665 17 63406334
Inappropriate schedule of product administration 25.78 13.66 61 82610 103904 63302447
Blood creatine increased 25.64 13.66 34 82637 5567 63400784
Blood pressure systolic increased 25.51 13.66 15 82656 47382 63358969
Colon cancer recurrent 25.40 13.66 8 82663 88 63406263
Bradycardia 25.30 13.66 35 82636 73192 63333159
Heart rate increased 25.24 13.66 53 82618 94185 63312166
Blood phosphorus decreased 25.11 13.66 30 82641 4423 63401928
Osteoporosis 24.60 13.66 23 82648 57315 63349036
Product quality issue 24.60 13.66 8 82663 35857 63370494
Encapsulating peritoneal sclerosis 24.48 13.66 11 82660 339 63406012
Amnesia 24.20 13.66 22 82649 55563 63350788
Nasal septum perforation 24.15 13.66 14 82657 742 63405609
Catabolic state 24.10 13.66 7 82664 57 63406294
Pelvic abscess 24.08 13.66 19 82652 1679 63404672
Laryngeal dyspnoea 24.07 13.66 9 82662 171 63406180
Vasospasm 24.05 13.66 14 82657 748 63405603
Cardiac ventricular thrombosis 23.96 13.66 13 82658 606 63405745
Diaphragmatic paralysis 23.86 13.66 13 82658 611 63405740
Radiation skin injury 23.77 13.66 15 82656 928 63405423
Full blood count decreased 23.62 13.66 3 82668 26021 63380330
Acute leukaemia 23.60 13.66 16 82655 1118 63405233
Oesophagitis 23.57 13.66 57 82614 14951 63391400
Thrombotic thrombocytopenic purpura 23.56 13.66 27 82644 3809 63402542
Stomatitis haemorrhagic 23.50 13.66 6 82665 28 63406323
Colon cancer metastatic 23.39 13.66 16 82655 1135 63405216
Hypocapnia 23.31 13.66 11 82660 380 63405971
Aortic dissection 23.22 13.66 20 82651 1998 63404353
Tympanic membrane disorder 23.19 13.66 9 82662 190 63406161
Electrocardiogram ST segment elevation 23.04 13.66 27 82644 3900 63402451
Underdose 23.00 13.66 4 82667 27452 63378899
Cardiogenic shock 22.89 13.66 63 82608 17869 63388482
Gastric disorder 22.85 13.66 10 82661 37359 63368992
Chronic myeloid leukaemia 22.76 13.66 21 82650 2297 63404054
Vision blurred 22.74 13.66 54 82617 91870 63314481
Gastrointestinal stoma complication 22.61 13.66 19 82652 1836 63404515
Tumour haemorrhage 22.59 13.66 18 82653 1613 63404738
Hepatic cytolysis 22.59 13.66 57 82614 15350 63391001
Urinary tract infection 22.53 13.66 228 82443 264456 63141895
Impaired healing 22.49 13.66 64 82607 102478 63303873
Tonic clonic movements 22.41 13.66 17 82654 1418 63404933
Hallucination 22.35 13.66 23 82648 54794 63351557
Lymphangiosis carcinomatosa 22.30 13.66 17 82654 1428 63404923
Carbohydrate antigen 15-3 increased 22.27 13.66 17 82654 1431 63404920
Growth of eyelashes 22.23 13.66 9 82662 213 63406138
Electrolyte imbalance 22.21 13.66 67 82604 20009 63386342
Thrombotic microangiopathy 22.11 13.66 45 82626 10516 63395835
Hypervolaemia 22.00 13.66 5 82666 28408 63377943
Sinus disorder 21.88 13.66 3 82668 24550 63381801
Depilation 21.84 13.66 5 82666 13 63406338
Soft tissue necrosis 21.81 13.66 12 82659 575 63405776
Nephrolithiasis 21.61 13.66 14 82657 41970 63364381
Recurrent cancer 21.47 13.66 19 82652 1968 63404383
Metastases to pelvis 21.37 13.66 11 82660 460 63405891
Sciatica 21.28 13.66 9 82662 34315 63372036
Treatment noncompliance 21.27 13.66 11 82660 37314 63369037
Tumour marker increased 21.22 13.66 29 82642 4886 63401465
Aortic intramural haematoma 21.16 13.66 7 82664 91 63406260
Foot fracture 21.12 13.66 3 82668 23911 63382440
Nail disorder 21.05 13.66 50 82621 12965 63393386
Psychotic disorder 20.99 13.66 4 82667 25708 63380643
Therapy interrupted 20.95 13.66 8 82663 32447 63373904
Catheter site bruise 20.94 13.66 11 82660 480 63405871
Systemic infection 20.89 13.66 28 82643 4632 63401719
Atrial thrombosis 20.88 13.66 18 82653 1800 63404551
Pulmonary alveolar haemorrhage 20.85 13.66 28 82643 4640 63401711
Type II hypersensitivity 20.84 13.66 5 82666 17 63406334
Cardiomyopathy acute 20.76 13.66 9 82662 254 63406097
Recall phenomenon 20.67 13.66 12 82659 638 63405713
Cough 20.66 13.66 263 82408 292480 63113871
Oral pain 20.30 13.66 82 82589 28312 63378039
Hypersensitivity 20.27 13.66 264 82407 292421 63113930
Cholestasis 20.25 13.66 84 82587 29350 63377001
Fistula 20.25 13.66 43 82628 10350 63396001
Rectal cancer recurrent 20.20 13.66 5 82666 20 63406331
Full blood count abnormal 20.18 13.66 8 82663 31709 63374642
Renal tubular disorder 20.17 13.66 21 82650 2661 63403690
Medication error 20.13 13.66 23 82648 52261 63354090
Productive cough 20.09 13.66 32 82639 63176 63343175
Multiple-drug resistance 20.09 13.66 29 82642 5141 63401210
Wrong rate 20.03 13.66 6 82665 55 63406296
Myeloproliferative neoplasm 19.94 13.66 11 82660 530 63405821
Duodenal perforation 19.90 13.66 13 82658 854 63405497
Superior vena cava syndrome 19.86 13.66 12 82659 687 63405664
K-ras gene mutation 19.82 13.66 5 82666 22 63406329
Biliary tract infection 19.81 13.66 12 82659 690 63405661
Pelvic fluid collection 19.78 13.66 13 82658 863 63405488
No adverse event 19.73 13.66 15 82656 41390 63364961
Hyperpyrexia 19.71 13.66 24 82647 3608 63402743
Dysphagia 19.71 13.66 189 82482 88396 63317955
Hyperkalaemia 19.65 13.66 25 82646 54178 63352173
Aorto-oesophageal fistula 19.64 13.66 5 82666 23 63406328
Wernicke's encephalopathy 19.64 13.66 5 82666 23 63406328
Macular degeneration 19.46 13.66 4 82667 24372 63381979
Multiple sclerosis 19.46 13.66 4 82667 24368 63381983
Tachycardia 19.29 13.66 237 82434 117919 63288432
Lichenoid keratosis 19.17 13.66 17 82654 1766 63404585
Portal vein dilatation 19.14 13.66 5 82666 26 63406325
Head injury 18.98 13.66 6 82665 27390 63378961
Altered state of consciousness 18.95 13.66 74 82597 25156 63381195
Live birth 18.89 13.66 5 82666 25625 63380726
Neutrophil count abnormal 18.86 13.66 21 82650 2871 63403480
Vaginal fistula 18.83 13.66 10 82661 446 63405905
Respiratory disorder 18.83 13.66 14 82657 39068 63367283
Gait apraxia 18.83 13.66 5 82666 28 63406323
Gastrointestinal anastomotic leak 18.82 13.66 8 82663 215 63406136
Protein urine 18.76 13.66 12 82659 760 63405591
Hypoalbuminaemia 18.71 13.66 45 82626 11760 63394591
Systolic dysfunction 18.71 13.66 16 82655 1583 63404768
Cerebral infarction 18.70 13.66 71 82600 23822 63382529
Dysphonia 18.69 13.66 116 82555 47498 63358853
Anastomotic complication 18.62 13.66 7 82664 135 63406216
Erythema 18.61 13.66 327 82344 175424 63230927
Localised infection 18.60 13.66 8 82663 30202 63376149
Aggression 18.46 13.66 4 82667 23494 63382857
Cardiac myxoma 18.45 13.66 8 82663 226 63406125
Systemic scleroderma 18.44 13.66 13 82658 968 63405383
Gastrointestinal stoma output increased 18.40 13.66 9 82662 337 63406014
Pneumatosis intestinalis 18.34 13.66 19 82652 2394 63403957
Intestinal ischaemia 18.29 13.66 34 82637 7434 63398917
Palpitations 18.28 13.66 80 82591 112690 63293661
Enterocolitis infectious 18.21 13.66 16 82655 1642 63404709
Hepatic function abnormal 18.20 13.66 96 82575 37046 63369305
Venous thrombosis limb 18.18 13.66 21 82650 2987 63403364
Hepatic vein stenosis 18.13 13.66 5 82666 33 63406318
Hypertension 18.10 13.66 484 82187 278819 63127532
Pigmentation disorder 17.99 13.66 26 82645 4613 63401738
Oesophageal varices haemorrhage 17.92 13.66 14 82657 1220 63405131
Cutaneous tuberculosis 17.90 13.66 7 82664 151 63406200
Chemical burns of eye 17.73 13.66 6 82665 84 63406267
Joint stiffness 17.72 13.66 17 82654 41852 63364499
Toxic cardiomyopathy 17.64 13.66 7 82664 157 63406194
Marchiafava-Bignami disease 17.58 13.66 4 82667 10 63406341
Carbohydrate antigen 19-9 increased 17.55 13.66 8 82663 255 63406096
Xerophthalmia 17.50 13.66 10 82661 516 63405835
Anorectal disorder 17.47 13.66 16 82655 1733 63404618
Rib fracture 17.45 13.66 4 82667 22593 63383758
Fistula of small intestine 17.43 13.66 9 82662 379 63405972
Transaminases increased 17.42 13.66 84 82587 31283 63375068
Necrosis 17.39 13.66 28 82643 5459 63400892
Splenic marginal zone lymphoma recurrent 17.31 13.66 4 82667 11 63406340
Endocardial fibrosis 17.31 13.66 4 82667 11 63406340
Blood creatine phosphokinase increased 17.29 13.66 9 82662 30421 63375930
SAPHO syndrome 17.17 13.66 6 82665 93 63406258
Pulmonary artery thrombosis 17.17 13.66 11 82660 699 63405652
Malignant peritoneal neoplasm 17.07 13.66 11 82660 706 63405645
Brachiocephalic vein thrombosis 17.05 13.66 6 82665 95 63406256
Endometrial dysplasia 17.05 13.66 4 82667 12 63406339
Vascular access site swelling 16.94 13.66 3 82668 0 63406351
Percussion test abnormal 16.94 13.66 3 82668 0 63406351
Vesical fistula 16.88 13.66 6 82665 98 63406253
Device issue 16.85 13.66 5 82666 23776 63382575
Haemolysis 16.81 13.66 31 82640 6737 63399614
Dry eye 16.73 13.66 17 82654 40744 63365607
Dandy-Walker syndrome 16.72 13.66 6 82665 101 63406250
Retroperitoneal abscess 16.58 13.66 7 82664 185 63406166
Withdrawal syndrome 16.56 13.66 3 82668 19994 63386357
Metastatic neoplasm 16.55 13.66 24 82647 4271 63402080
Musculoskeletal pain 16.50 13.66 63 82608 92214 63314137
Monoparesis 16.48 13.66 15 82656 1612 63404739
Ischaemic enteritis 16.39 13.66 5 82666 49 63406302
Skin disorder 16.38 13.66 79 82592 29428 63376923
Portal shunt 16.37 13.66 4 82667 15 63406336
Hiatus hernia 16.32 13.66 4 82667 21590 63384761
Periodontal disease 16.31 13.66 15 82656 1633 63404718
Procedural pain 16.29 13.66 4 82667 21565 63384786
Skin exfoliation 16.29 13.66 104 82567 42998 63363353
Foot deformity 16.18 13.66 8 82663 27845 63378506
Acute pulmonary oedema 16.18 13.66 34 82637 8124 63398227
Peripheral nerve injury 16.15 13.66 9 82662 442 63405909
Gastric perforation 16.08 13.66 15 82656 1664 63404687
Mixed adenoneuroendocrine carcinoma 15.97 13.66 4 82667 17 63406334
Ocular vasculitis 15.96 13.66 5 82666 54 63406297
Surgery 15.88 13.66 14 82657 35898 63370453
Menopause 15.88 13.66 19 82652 2806 63403545
Mental disorder 15.74 13.66 7 82664 25912 63380439
Eosinophilia 15.74 13.66 5 82666 22751 63383600
Hypertensive encephalopathy 15.71 13.66 10 82661 628 63405723
Liver function test abnormal 15.69 13.66 24 82647 48157 63358194
Malignant neoplasm of pleura 15.63 13.66 5 82666 58 63406293
Vitamin B1 deficiency 15.60 13.66 8 82663 332 63406019
Ileus paralytic 15.50 13.66 24 82647 4527 63401824
Gas gangrene 15.49 13.66 6 82665 126 63406225
T-cell type acute leukaemia 15.48 13.66 5 82666 60 63406291
Small intestinal perforation 15.41 13.66 14 82657 1501 63404850
Intravascular haemolysis 15.36 13.66 8 82663 343 63406008
Diabetes mellitus 15.27 13.66 31 82640 55779 63350572
International normalised ratio increased 15.23 13.66 23 82648 46402 63359949
Pneumonitis 15.22 13.66 88 82583 35134 63371217
Oesophageal stenosis 15.22 13.66 20 82651 3246 63403105
Herpes simplex encephalitis 15.19 13.66 8 82663 351 63406000
Hyponatraemia 15.17 13.66 217 82454 111683 63294668
Red blood cell nucleated morphology present 15.12 13.66 4 82667 22 63406329
Bone marrow infiltration 15.08 13.66 10 82661 674 63405677
Infection 15.03 13.66 209 82462 228964 63177387
Duodenal ulcer 15.01 13.66 32 82639 7724 63398627
Anal inflammation 14.94 13.66 7 82664 238 63406113
Bronchospasm 14.91 13.66 53 82618 17227 63389124
Chemotherapy 14.91 13.66 14 82657 1565 63404786
Pulmonary fistula 14.86 13.66 3 82668 3 63406348
Performance status decreased 14.83 13.66 21 82650 3657 63402694
Pulmonary veno-occlusive disease 14.74 13.66 12 82659 1109 63405242
Anaemia of malignant disease 14.73 13.66 9 82662 526 63405825
Gastrointestinal motility disorder 14.72 13.66 25 82646 5094 63401257
Disability 14.67 13.66 3 82668 18344 63388007
Crying 14.66 13.66 6 82665 23337 63383014
Cystitis 14.66 13.66 31 82640 54960 63351391
Blood alkaline phosphatase increased 14.62 13.66 101 82570 42866 63363485
Mucosal disorder 14.58 13.66 16 82655 2153 63404198
Extrasystoles 14.57 13.66 25 82646 5135 63401216
Pancreatitis acute 14.55 13.66 72 82599 27094 63379257
Metastases to neck 14.52 13.66 5 82666 74 63406277
Scintillating scotoma 14.52 13.66 6 82665 150 63406201
Onycholysis 14.49 13.66 14 82657 1622 63404729
Blood glucose increased 14.45 13.66 58 82613 83698 63322653
Dysaesthesia pharynx 14.44 13.66 6 82665 152 63406199
Nephrotic syndrome 14.43 13.66 26 82645 5550 63400801
Acute polyneuropathy 14.42 13.66 7 82664 258 63406093
Lymphadenopathy mediastinal 14.35 13.66 18 82653 2790 63403561
Spinal cord compression 14.30 13.66 22 82649 4126 63402225
Accidental exposure to product 14.29 13.66 9 82662 27396 63378955
Pericardial effusion 14.25 13.66 77 82594 29981 63376370
Musculoskeletal discomfort 14.24 13.66 3 82668 17964 63388387
Metastases to eye 14.23 13.66 6 82665 158 63406193
Abdominal abscess 14.21 13.66 23 82648 4503 63401848
Endothelial dysfunction 14.19 13.66 6 82665 159 63406192
Gingival atrophy 14.18 13.66 4 82667 29 63406322
Wound dehiscence 14.17 13.66 24 82647 4879 63401472
Exostosis 14.12 13.66 3 82668 17859 63388492
Ankle fracture 14.11 13.66 3 82668 17852 63388499
Rash pruritic 14.10 13.66 36 82635 59763 63346588
HER2 gene amplification 14.06 13.66 4 82667 30 63406321
Arterial thrombosis 14.03 13.66 13 82658 1430 63404921
Eye disorder 13.98 13.66 6 82665 22679 63383672
Colon cancer 13.92 13.66 36 82635 9842 63396509
Limb injury 13.80 13.66 8 82663 25469 63380882
Product intolerance 13.73 13.66 4 82667 33 63406318

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1326.84 13.79 1858 92381 154920 34707772
Diarrhoea 1041.05 13.79 2830 91409 387082 34475610
Dermatitis acneiform 1007.62 13.79 437 93802 5752 34856940
Neuropathy peripheral 888.05 13.79 1107 93132 82156 34780536
Skin toxicity 772.85 13.79 336 93903 4448 34858244
Mucosal inflammation 745.63 13.79 703 93536 37919 34824773
Disease progression 632.29 13.79 1082 93157 106995 34755697
Stomatitis 623.98 13.79 667 93572 41847 34820845
Arteriospasm coronary 617.23 13.79 259 93980 3123 34859569
Paronychia 513.86 13.79 228 94011 3177 34859515
Thrombocytopenia 486.05 13.79 1205 93034 155042 34707650
Palmar-plantar erythrodysaesthesia syndrome 470.02 13.79 378 93861 16417 34846275
Metastases to liver 419.94 13.79 325 93914 13338 34849354
Neurotoxicity 404.31 13.79 357 93882 17653 34845039
Interstitial lung disease 373.82 13.79 648 93591 64634 34798058
Leukopenia 343.12 13.79 611 93628 62245 34800447
Peripheral sensory neuropathy 321.74 13.79 210 94029 6550 34856142
Decreased appetite 319.65 13.79 1080 93159 165312 34697380
Febrile neutropenia 287.55 13.79 916 93323 135933 34726759
Gastrointestinal toxicity 271.56 13.79 137 94102 2582 34860110
Polyneuropathy 264.19 13.79 259 93980 14637 34848055
Nausea 261.52 13.79 1686 92553 338222 34524470
Malignant neoplasm progression 250.19 13.79 657 93582 87389 34775303
Cardiotoxicity 248.31 13.79 167 94072 5481 34857211
Hyperammonaemia 239.39 13.79 171 94068 6196 34856496
Vomiting 237.50 13.79 1302 92937 246319 34616373
Completed suicide 232.57 13.79 7 94232 98161 34764531
Metastases to lung 231.91 13.79 196 94043 9124 34853568
Hypomagnesaemia 231.43 13.79 290 93949 21561 34841131
Arthralgia 227.56 13.79 87 94152 169954 34692738
Myelosuppression 215.80 13.79 263 93976 19002 34843690
Product dose omission issue 212.65 13.79 34 94205 119677 34743015
Drug interaction 208.23 13.79 182 94057 225764 34636928
Bone marrow failure 201.78 13.79 316 93923 28937 34833755
Gastrointestinal perforation 201.12 13.79 127 94112 3736 34858956
Proteinuria 196.75 13.79 247 93992 18395 34844297
Drug ineffective 190.72 13.79 616 93623 456135 34406557
Dehydration 186.81 13.79 769 93470 129200 34733492
Neoplasm progression 180.96 13.79 266 93973 23034 34839658
Skin reaction 179.66 13.79 133 94106 5097 34857595
Hyperammonaemic encephalopathy 177.81 13.79 98 94141 2226 34860466
General physical health deterioration 168.09 13.79 738 93501 127531 34735161
Neutrophil count decreased 166.63 13.79 402 93837 50702 34811990
Pneumatosis intestinalis 165.31 13.79 113 94126 3810 34858882
Haematotoxicity 161.42 13.79 151 94088 8043 34854649
Headache 155.94 13.79 187 94052 200448 34662244
Therapy partial responder 146.41 13.79 154 94085 9462 34853230
Carcinoembryonic antigen increased 145.61 13.79 59 94180 646 34862046
Portal hypertension 143.36 13.79 105 94134 3957 34858735
Intestinal obstruction 142.96 13.79 236 94003 22586 34840106
Alopecia 139.51 13.79 242 93997 24113 34838579
Rash pustular 139.22 13.79 116 94123 5292 34857400
Portal venous gas 132.78 13.79 47 94192 342 34862350
Enteritis 132.25 13.79 135 94104 8007 34854685
Fall 129.00 13.79 218 94021 202667 34660025
Weight increased 120.39 13.79 50 94189 92983 34769709
Pyrexia 117.60 13.79 1392 92847 331621 34531071
Rhabdomyolysis 115.20 13.79 22 94217 68141 34794551
Pulmonary embolism 113.39 13.79 511 93728 89235 34773457
Anxiety 111.17 13.79 65 94174 99363 34763329
Chills 111.17 13.79 473 93766 80570 34782122
Cardiac failure congestive 108.95 13.79 44 94195 83226 34779466
Paraesthesia 105.20 13.79 396 93843 63776 34798916
Myalgia 104.39 13.79 48 94191 84062 34778630
Depression 102.30 13.79 68 94171 97030 34765662
Hospitalisation 101.33 13.79 16 94223 56886 34805806
Colorectal cancer metastatic 100.36 13.79 46 94193 694 34861998
Metastases to peritoneum 99.44 13.79 62 94177 1782 34860910
Insomnia 96.37 13.79 83 94156 103824 34758868
Intentional product misuse 95.97 13.79 7 94232 45604 34817088
Peritonitis 95.53 13.79 164 94075 16201 34846491
Abdominal pain 94.58 13.79 759 93480 162859 34699833
Somnolence 92.27 13.79 98 94141 111018 34751674
Suicide attempt 91.83 13.79 3 94236 39113 34823579
Ileus 90.66 13.79 161 94078 16338 34846354
Pain in extremity 89.84 13.79 126 94113 126387 34736305
Tumour necrosis 89.52 13.79 51 94188 1237 34861455
Hypokalaemia 87.06 13.79 349 93890 57865 34804827
Peripheral swelling 87.03 13.79 49 94190 76492 34786200
Toxicity to various agents 86.13 13.79 266 93973 200096 34662596
Hiccups 85.43 13.79 120 94119 9962 34852730
Subileus 85.14 13.79 70 94169 3133 34859559
Injection site pain 84.98 13.79 5 94234 39000 34823692
Asthenia 84.96 13.79 1022 93217 244229 34618463
Aggression 84.87 13.79 5 94234 38959 34823733
Joint swelling 84.49 13.79 28 94211 59862 34802830
Asthma 83.13 13.79 9 94230 42647 34820045
Oesophageal fistula 82.85 13.79 31 94208 269 34862423
Chronic obstructive pulmonary disease 82.20 13.79 16 94223 48902 34813790
Hallucination 82.12 13.79 19 94220 51479 34811213
Folliculitis 82.07 13.79 80 94159 4486 34858206
Metastases to lymph nodes 81.56 13.79 81 94158 4647 34858045
Death 81.41 13.79 685 93554 397364 34465328
Suicidal ideation 80.05 13.79 8 94231 40380 34822312
Mucosal toxicity 79.55 13.79 29 94210 232 34862460
Extravasation 78.59 13.79 54 94185 1836 34860856
Electrocardiogram ST segment elevation 78.15 13.79 83 94156 5155 34857537
Ileal perforation 77.67 13.79 39 94200 727 34861965
Overdose 77.06 13.79 79 94160 90980 34771712
Pneumonia 76.87 13.79 618 93621 362009 34500683
Leukoencephalopathy 76.04 13.79 74 94165 4141 34858551
Device related infection 75.85 13.79 153 94086 17084 34845608
Pelvic abscess 75.72 13.79 41 94198 898 34861794
Anastomotic leak 75.59 13.79 36 94203 595 34862097
Large intestine perforation 74.72 13.79 103 94136 8400 34854292
Anastomotic complication 73.83 13.79 31 94208 374 34862318
Septic shock 73.41 13.79 385 93854 71449 34791243
Rheumatoid arthritis 72.19 13.79 9 94230 38229 34824463
Small intestinal obstruction 71.53 13.79 137 94102 14729 34847963
Psoriasis 71.20 13.79 10 94229 38802 34823890
Influenza 70.44 13.79 23 94216 49643 34813049
Acute coronary syndrome 70.37 13.79 129 94110 13416 34849276
Cholangitis 70.05 13.79 101 94138 8588 34854104
Aorto-oesophageal fistula 69.20 13.79 18 94221 35 34862657
Stress 68.93 13.79 3 94236 30344 34832348
Wheezing 68.60 13.79 14 94225 41388 34821304
Therapeutic product effect decreased 68.55 13.79 7 94232 34736 34827956
Focal nodular hyperplasia 68.47 13.79 23 94216 140 34862552
Feeling abnormal 68.33 13.79 43 94196 63192 34799500
Administration site extravasation 67.88 13.79 33 94206 572 34862120
Disseminated intravascular coagulation 67.21 13.79 168 94071 21648 34841044
Toxic leukoencephalopathy 67.13 13.79 29 94210 377 34862315
Necrotising fasciitis 66.50 13.79 65 94174 3657 34859035
Dermatitis 66.25 13.79 103 94136 9365 34853327
Tumour perforation 66.12 13.79 27 94212 302 34862390
Blood glucose increased 65.94 13.79 50 94189 66668 34796024
Muscle spasms 65.83 13.79 63 94176 74938 34787754
Conjunctivitis 65.72 13.79 104 94135 9601 34853091
Dizziness 65.35 13.79 335 93904 218186 34644506
Sinusitis 64.58 13.79 16 94223 41386 34821306
Oesophagitis 63.54 13.79 122 94117 13139 34849553
Intravascular haemolysis 63.30 13.79 29 94210 437 34862255
Incorrect dose administered 62.54 13.79 16 94223 40499 34822193
Nasopharyngitis 61.14 13.79 59 94180 69909 34792783
Agitation 59.35 13.79 41 94198 57358 34805334
Drug reaction with eosinophilia and systemic symptoms 57.17 13.79 10 94229 33002 34829690
Ascites 57.13 13.79 263 93976 46308 34816384
Cholinergic syndrome 56.93 13.79 29 94210 558 34862134
Contusion 56.82 13.79 14 94225 36350 34826342
Skin fissures 55.97 13.79 70 94169 5189 34857503
Anaemia 55.85 13.79 911 93328 232424 34630268
Musculoskeletal stiffness 55.81 13.79 28 94211 46652 34816040
Intestinal perforation 55.79 13.79 93 94146 8967 34853725
Confusional state 55.30 13.79 201 94038 143959 34718733
Prostate cancer 55.11 13.79 19 94220 39630 34823062
Dry skin 54.53 13.79 197 94042 31090 34831602
Hyperbilirubinaemia 54.31 13.79 132 94107 16711 34845981
Bradycardia 52.62 13.79 76 94163 75342 34787350
Venous thrombosis 52.26 13.79 55 94184 3380 34859312
Disturbance in attention 51.78 13.79 5 94234 25940 34836752
Memory impairment 51.77 13.79 26 94213 43292 34819400
Foetal exposure during pregnancy 51.69 13.79 19 94220 38082 34824610
Electrocardiogram QT prolonged 51.36 13.79 23 94216 40929 34821763
Pain 50.87 13.79 333 93906 204342 34658350
Large intestinal obstruction 50.40 13.79 38 94201 1497 34861195
Rectal perforation 50.33 13.79 25 94214 455 34862237
Hypertransaminasaemia 49.40 13.79 68 94171 5538 34857154
Abdominal discomfort 49.38 13.79 53 94186 59782 34802910
Coronary artery disease 49.29 13.79 35 94204 48270 34814422
Epistaxis 48.77 13.79 296 93943 57955 34804737
Tremor 48.55 13.79 93 94146 82494 34780198
Treatment noncompliance 47.61 13.79 9 94230 28091 34834601
Carbohydrate antigen 19-9 increased 47.47 13.79 19 94220 201 34862491
Oesophagobronchial fistula 46.96 13.79 18 94221 168 34862524
Product use issue 46.81 13.79 61 94178 63155 34799537
Skin disorder 46.69 13.79 109 94130 13446 34849246
Small intestinal perforation 46.63 13.79 42 94197 2129 34860563
Anastomotic fistula 46.47 13.79 15 94224 79 34862613
Recall phenomenon 46.23 13.79 25 94214 546 34862146
Hypersensitivity 46.04 13.79 302 93937 60733 34801959
Myocardial infarction 45.65 13.79 170 94069 120915 34741777
Arthritis 45.36 13.79 14 94225 31332 34831360
Subclavian vein thrombosis 45.35 13.79 29 94210 872 34861820
Pulmonary artery thrombosis 45.07 13.79 27 94212 721 34861971
Cellulitis 44.71 13.79 46 94193 52905 34809787
Unevaluable event 44.64 13.79 16 94223 32574 34830118
COVID-19 44.13 13.79 89 94150 77461 34785231
Aortic thrombosis 44.09 13.79 27 94212 751 34861941
Injury 44.02 13.79 3 94236 20684 34842008
Dysphagia 43.66 13.79 303 93936 62078 34800614
Tumour lysis syndrome 43.05 13.79 122 94117 16937 34845755
Malignant ascites 42.97 13.79 22 94217 428 34862264
Venoocclusive liver disease 42.81 13.79 77 94162 7889 34854803
Duodenal perforation 42.77 13.79 32 94207 1246 34861446
Condition aggravated 42.69 13.79 323 93916 191873 34670819
Colon cancer recurrent 42.51 13.79 15 94224 108 34862584
Enterocolitis 42.40 13.79 77 94162 7949 34854743
Hepatic lesion 42.07 13.79 51 94188 3661 34859031
Drug hypersensitivity 41.22 13.79 98 94141 80431 34782261
Intentional product use issue 41.01 13.79 61 94178 59755 34802937
Acral peeling skin syndrome 40.66 13.79 12 94227 44 34862648
Transdifferentiation of neoplasm 40.34 13.79 13 94226 68 34862624
Oesophageal stenosis 40.21 13.79 35 94204 1695 34860997
Colitis 39.69 13.79 204 94035 37546 34825146
Irritability 39.57 13.79 9 94230 24681 34838011
Vena cava thrombosis 39.57 13.79 30 94209 1192 34861500
Cardiac disorder 39.28 13.79 35 94204 43091 34819601
Drug withdrawal syndrome 39.11 13.79 4 94235 19830 34842862
Cytomegalovirus infection 39.05 13.79 11 94228 26124 34836568
Psychotic disorder 39.02 13.79 9 94230 24443 34838249
Fluid retention 38.92 13.79 12 94227 26875 34835817
Blood pressure fluctuation 38.91 13.79 10 94229 25239 34837453
Device related thrombosis 38.83 13.79 29 94210 1126 34861566
Neutropenic colitis 38.61 13.79 45 94194 3099 34859593
Abnormal behaviour 38.26 13.79 10 94229 24959 34837733
Vasospasm 38.19 13.79 19 94220 347 34862345
Portal vein thrombosis 38.07 13.79 49 94190 3739 34858953
Cachexia 38.03 13.79 69 94170 7117 34855575
Anal erythema 37.78 13.79 13 94226 86 34862606
Blood pressure increased 37.75 13.79 117 94122 87985 34774707
Intestinal ischaemia 37.70 13.79 72 94167 7722 34854970
Prinzmetal angina 37.45 13.79 27 94212 992 34861700
Balance disorder 37.02 13.79 33 94206 40621 34822071
Xerosis 36.91 13.79 22 94217 582 34862110
Adenocarcinoma 36.77 13.79 35 94204 1905 34860787
Incorrect drug administration rate 36.65 13.79 33 94206 1672 34861020
Fistula 36.61 13.79 66 94173 6774 34855918
Acute abdomen 36.54 13.79 35 94204 1920 34860772
Respiratory arrest 36.36 13.79 15 94224 28028 34834664
White blood cell count decreased 36.14 13.79 405 93834 95040 34767652
Neoplasm recurrence 35.99 13.79 37 94202 2212 34860480
Nicotinic acid deficiency 35.77 13.79 13 94226 103 34862589
Tumour haemorrhage 35.72 13.79 42 94197 2920 34859772
Chronic kidney disease 35.70 13.79 35 94204 41175 34821517
Enterovesical fistula 35.69 13.79 24 94215 787 34861905
Bacterial translocation 35.54 13.79 18 94221 342 34862350
Hypoglycaemia 35.29 13.79 58 94181 54582 34808110
Loss of personal independence in daily activities 35.23 13.79 23 94216 33156 34829536
Type II hypersensitivity 35.16 13.79 10 94229 31 34862661
Embolism 35.05 13.79 70 94169 7759 34854933
Stress cardiomyopathy 35.01 13.79 35 94204 2024 34860668
Rectal tenesmus 34.62 13.79 24 94215 828 34861864
Hyperkalaemia 34.29 13.79 86 94153 69303 34793389
Pelvic fluid collection 34.09 13.79 14 94225 159 34862533
Dysphonia 33.98 13.79 139 94100 23244 34839448
Liver abscess 33.95 13.79 47 94192 3848 34858844
Gastrointestinal necrosis 33.90 13.79 44 94195 3385 34859307
Laryngospasm 33.81 13.79 30 94209 1491 34861201
Colon cancer metastatic 33.69 13.79 31 94208 1616 34861076
Drug level increased 33.57 13.79 9 94230 22087 34840605
Adverse drug reaction 33.02 13.79 19 94220 29323 34833369
Sedation 32.99 13.79 8 94231 20998 34841694
Biliary tract infection 32.76 13.79 21 94218 634 34862058
International normalised ratio increased 32.70 13.79 48 94191 47279 34815413
Hypoalbuminaemia 32.62 13.79 89 94150 12085 34850607
Cough 32.53 13.79 254 93985 149886 34712806
Eosinophilia 32.45 13.79 15 94224 26207 34836485
Neutropenic sepsis 32.37 13.79 96 94143 13671 34849021
Nephrolithiasis 32.25 13.79 21 94218 30312 34832380
Perforation 31.88 13.79 15 94224 241 34862451
Anal haemorrhage 31.83 13.79 37 94202 2541 34860151
Odynophagia 31.78 13.79 55 94184 5466 34857226
Nodular regenerative hyperplasia 31.75 13.79 24 94215 949 34861743
Induration 31.71 13.79 24 94215 951 34861741
Full blood count abnormal 31.58 13.79 6 94233 18662 34844030
Bronchitis 31.57 13.79 40 94199 41923 34820769
Blood creatine phosphokinase increased 31.48 13.79 45 94194 44812 34817880
Balanoposthitis 31.42 13.79 26 94213 1174 34861518
Stoma site haemorrhage 31.39 13.79 23 94216 867 34861825
Proteus infection 31.14 13.79 25 94214 1081 34861611
Gait disturbance 31.12 13.79 121 94118 85019 34777673
Oral pain 30.88 13.79 81 94158 10746 34851946
Dyspnoea 30.87 13.79 777 93462 376005 34486687
Gastric perforation 30.83 13.79 36 94203 2484 34860208
Head injury 30.37 13.79 6 94233 18154 34844538
Blood cholesterol increased 30.04 13.79 9 94230 20534 34842158
Peritoneal neoplasm 29.88 13.79 9 94230 36 34862656
Heart rate decreased 29.84 13.79 25 94214 31720 34830972
Cytomegalovirus oesophagitis 29.80 13.79 18 94221 488 34862204
Tracheal stenosis 29.75 13.79 14 94225 225 34862467
Hypophagia 29.69 13.79 136 94103 23886 34838806
Nail toxicity 29.69 13.79 9 94230 37 34862655
Sleep apnoea syndrome 29.54 13.79 9 94230 20312 34842380
Inappropriate schedule of product administration 29.40 13.79 79 94160 62217 34800475
Palmar erythema 29.10 13.79 15 94224 296 34862396
Deep vein thrombosis 28.98 13.79 286 93953 64962 34797730
Peripheral sensorimotor neuropathy 28.96 13.79 28 94211 1554 34861138
Sciatic nerve palsy 28.95 13.79 9 94230 41 34862651
Hypovolaemic shock 28.94 13.79 61 94178 7024 34855668
Erythema 28.88 13.79 366 93873 88414 34774278
Jugular vein thrombosis 28.88 13.79 29 94210 1686 34861006
Perforation bile duct 28.84 13.79 8 94231 22 34862670
Urticaria 28.77 13.79 80 94159 62297 34800395
Liver function test abnormal 28.56 13.79 25 94214 31049 34831643
Cytokine release syndrome 28.45 13.79 13 94226 22864 34839828
Lower respiratory tract infection 28.42 13.79 26 94213 31611 34831081
Diabetes mellitus 28.22 13.79 52 94187 46821 34815871
Influenza like illness 28.21 13.79 20 94219 27614 34835078
Rectal cancer metastatic 28.13 13.79 13 94226 200 34862492
Subdural haematoma 28.01 13.79 10 94229 20411 34842281
Renal disorder 27.97 13.79 17 94222 25463 34837229
Mouth ulceration 27.95 13.79 83 94156 11827 34850865
Dihydropyrimidine dehydrogenase deficiency 27.88 13.79 10 94229 76 34862616
Tumour marker increased 27.80 13.79 19 94220 640 34862052
Acne 27.78 13.79 79 94160 10987 34851705
Aphthous ulcer 27.76 13.79 49 94190 4946 34857746
Vocal cord paralysis 27.55 13.79 22 94217 944 34861748
Swelling 27.33 13.79 45 94194 42321 34820371
Emotional distress 27.25 13.79 4 94235 15022 34847670
Abdominal abscess 27.25 13.79 44 94195 4131 34858561
Drug ineffective for unapproved indication 27.20 13.79 15 94224 23700 34838992
Right ventricular ejection fraction decreased 26.90 13.79 9 94230 54 34862638
Arthropathy 26.79 13.79 20 94219 26887 34835805
Venous thrombosis limb 26.65 13.79 30 94209 1989 34860703
Colitis ulcerative 26.52 13.79 6 94233 16514 34846178
Enterocutaneous fistula 26.22 13.79 22 94217 1013 34861679
PIK3CA-activated mutation 26.21 13.79 10 94229 92 34862600
Pneumonitis chemical 26.12 13.79 12 94227 182 34862510
Pulmonary infarction 25.92 13.79 25 94214 1383 34861309
Respiratory depression 25.88 13.79 6 94233 16239 34846453
Pulmonary oedema 25.81 13.79 56 94183 47473 34815219
Anaemia of malignant disease 25.72 13.79 16 94223 458 34862234
Left ventricular dysfunction 25.67 13.79 72 94167 9935 34852757
Herpes zoster 25.66 13.79 33 94206 34366 34828326
Product prescribing error 25.58 13.79 15 94224 22912 34839780
Haematoma 25.53 13.79 19 94220 25586 34837106
Cell-mediated cytotoxicity 25.46 13.79 8 94231 38 34862654
Nephrotic syndrome 25.45 13.79 59 94180 7244 34855448
Splenomegaly 25.33 13.79 94 94145 15023 34847669
Evans syndrome 25.20 13.79 13 94226 257 34862435
Hepatectomy 25.13 13.79 9 94230 68 34862624
Vision blurred 25.09 13.79 54 94185 45909 34816783
Febrile bone marrow aplasia 25.05 13.79 63 94176 8146 34854546
Carbohydrate antigen 15-3 increased 25.02 13.79 9 94230 69 34862623
Pulmonary fibrosis 24.89 13.79 107 94132 18289 34844403
Hypervolaemia 24.82 13.79 11 94228 19698 34842994
Subacute cutaneous lupus erythematosus 24.77 13.79 21 94218 981 34861711
Colitis microscopic 24.70 13.79 31 94208 2306 34860386
Gastrointestinal ischaemia 24.68 13.79 12 94227 208 34862484
Catheter site thrombosis 24.64 13.79 10 94229 110 34862582
Prothrombin level decreased 24.58 13.79 22 94217 1106 34861586
Myoclonus 24.34 13.79 5 94234 14720 34847972
Nail disorder 24.28 13.79 29 94210 2050 34860642
Proctalgia 24.23 13.79 50 94189 5673 34857019
Hyperthermia 24.15 13.79 73 94166 10504 34852188
Gastrointestinal anastomotic leak 24.12 13.79 15 94224 429 34862263
Trichomegaly 24.08 13.79 7 94232 24 34862668
Gene mutation 24.06 13.79 24 94215 1384 34861308
Contraindicated product administered 24.04 13.79 14 94225 21467 34841225
Gout 23.85 13.79 11 94228 19242 34843450
Conjunctival filtering bleb leak 23.66 13.79 6 94233 10 34862682
Proctitis 23.55 13.79 31 94208 2418 34860274
Lymphoma 23.46 13.79 3 94236 12504 34850188
Oesophageal perforation 23.43 13.79 22 94217 1177 34861515
Wrong technique in product usage process 23.42 13.79 38 94201 35948 34826744
Pneumonitis 23.36 13.79 164 94075 33714 34828978
Dysaesthesia pharynx 23.24 13.79 8 94231 53 34862639
Koebner phenomenon 23.24 13.79 8 94231 53 34862639
Premature baby 23.13 13.79 12 94227 19621 34843071
Onychoclasis 23.01 13.79 27 94212 1873 34860819
Blood glucose decreased 22.94 13.79 4 94235 13233 34849459
Blood pressure systolic increased 22.92 13.79 17 94222 22935 34839757
Onycholysis 22.92 13.79 18 94221 754 34861938
Thrombotic thrombocytopenic purpura 22.66 13.79 36 94203 3334 34859358
Hypercreatininaemia 22.46 13.79 15 94224 486 34862206
Mobility decreased 22.37 13.79 29 94210 30099 34832593
Osteoarthritis 22.34 13.79 14 94225 20628 34842064
Erectile dysfunction 22.33 13.79 14 94225 20623 34842069
Hypoferritinaemia 22.33 13.79 6 94233 14 34862678
Ischaemic stroke 22.32 13.79 103 94136 18147 34844545
Prostatic specific antigen increased 22.26 13.79 6 94233 14674 34848018
Temperature intolerance 22.25 13.79 36 94203 3386 34859306
Treatment failure 22.20 13.79 59 94180 46638 34816054
Metastasis 22.20 13.79 40 94199 4104 34858588
Anger 21.94 13.79 3 94236 11881 34850811
Haemoglobinuria 21.93 13.79 16 94223 599 34862093
Thrombocytopenic purpura 21.86 13.79 21 94218 1156 34861536
Localised infection 21.86 13.79 10 94229 17577 34845115
Haemorrhagic tumour necrosis 21.67 13.79 5 94234 4 34862688
Dysentery 21.54 13.79 13 94226 352 34862340
Astringent therapy 21.50 13.79 6 94233 17 34862675
Perineal disorder 21.42 13.79 8 94231 69 34862623
Abdominal pain lower 21.41 13.79 70 94169 10501 34852191
Accidental overdose 21.33 13.79 14 94225 20126 34842566
Pachymeningitis 21.26 13.79 9 94230 111 34862581
Heart rate irregular 21.24 13.79 8 94231 15799 34846893
Angioedema 21.16 13.79 43 94196 37331 34825361
Varices oesophageal 21.08 13.79 37 94202 3718 34858974
Productive cough 20.99 13.79 44 94195 37769 34824923
Pneumoperitoneum 20.95 13.79 25 94214 1765 34860927
Heart rate increased 20.95 13.79 60 94179 46283 34816409
NPM1 gene mutation 20.83 13.79 9 94230 117 34862575
Necrotising oesophagitis 20.81 13.79 15 94224 551 34862141
Pseudocirrhosis 20.77 13.79 6 94233 20 34862672
Clostridial infection 20.70 13.79 36 94203 3591 34859101
Rectosigmoid cancer 20.69 13.79 10 94229 171 34862521
Nasal congestion 20.65 13.79 19 94220 23038 34839654
Dyskinesia 20.63 13.79 18 94221 22395 34840297
Hepatic atrophy 20.59 13.79 10 94229 173 34862519
Fistula of small intestine 20.58 13.79 14 94225 468 34862224
Hepatitis B 20.48 13.79 48 94191 5935 34856757
Hepatic enzyme increased 20.44 13.79 47 94192 39033 34823659
Hypercreatinaemia 20.43 13.79 10 94229 176 34862516
Visual impairment 20.43 13.79 41 94198 35761 34826931
Jaundice cholestatic 20.43 13.79 42 94197 4752 34857940
Stoma site pain 20.42 13.79 16 94223 668 34862024
Cerebral vasoconstriction 20.35 13.79 11 94228 240 34862452
Interventricular septum rupture 20.33 13.79 6 94233 22 34862670
Swollen tongue 20.29 13.79 7 94232 14598 34848094
Diffuse alveolar damage 20.28 13.79 28 94211 2286 34860406
Underdose 20.22 13.79 6 94233 13774 34848918
Hypertension 20.20 13.79 496 93743 135947 34726745
Adverse event 20.16 13.79 13 94226 18864 34843828
Protein urine 20.09 13.79 18 94221 906 34861786
Cerebrovascular accident 20.01 13.79 140 94099 84671 34778021
Muscular weakness 19.94 13.79 115 94124 72782 34789910
Mental disorder 19.93 13.79 8 94231 15201 34847491
Oesophageal carcinoma recurrent 19.92 13.79 6 94233 24 34862668
Oesophageal haemorrhage 19.87 13.79 21 94218 1297 34861395
Delirium 19.85 13.79 57 94182 43934 34818758
Injection site erythema 19.82 13.79 9 94230 15890 34846802
Mucocutaneous rash 19.73 13.79 6 94233 25 34862667
Vascular access complication 19.68 13.79 12 94227 331 34862361
Pulmonary toxicity 19.63 13.79 48 94191 6099 34856593
Refeeding syndrome 19.54 13.79 6 94233 26 34862666
Diabetes mellitus inadequate control 19.50 13.79 6 94233 13458 34849234
Microgenia 19.47 13.79 5 94234 9 34862683
Toxic erythema of chemotherapy 19.47 13.79 8 94231 91 34862601
Perioral dermatitis 19.44 13.79 9 94230 139 34862553
Pancreatitis 19.36 13.79 48 94191 38843 34823849
Dysgeusia 19.29 13.79 130 94109 26367 34836325
Limb injury 19.26 13.79 4 94235 11685 34851007
No adverse event 19.25 13.79 20 94219 22907 34839785
Growth of eyelashes 19.16 13.79 8 94231 95 34862597
Systemic infection 19.15 13.79 43 94196 5169 34857523
Enterocolitis haemorrhagic 19.14 13.79 18 94221 965 34861727
Ischiorectal hernia 19.13 13.79 5 94234 10 34862682
Soft tissue disorder 19.12 13.79 16 94223 734 34861958
Wound dehiscence 19.08 13.79 33 94206 3278 34859414
Laryngeal oedema 18.97 13.79 34 94205 3474 34859218
Oedema peripheral 18.96 13.79 219 94020 119593 34743099
Diaphragmatic operation 18.84 13.79 6 94233 30 34862662
Intestinal strangulation 18.84 13.79 6 94233 30 34862662
Osteomyelitis 18.81 13.79 10 94229 16126 34846566
Peritoneal haematoma 18.58 13.79 7 94232 62 34862630
Gastrointestinal obstruction 18.57 13.79 17 94222 880 34861812
Injection site reaction 18.54 13.79 6 94233 13027 34849665
Performance status decreased 18.53 13.79 37 94202 4100 34858592
Colorectal cancer recurrent 18.52 13.79 6 94233 32 34862660
Portal vein embolisation 18.51 13.79 5 94234 12 34862680
Swelling face 18.47 13.79 21 94218 23084 34839608
Seizure 18.46 13.79 187 94052 104670 34758022
Jaundice 18.40 13.79 148 94091 31734 34830958
Primitive neuroectodermal tumour 18.39 13.79 7 94232 64 34862628
Sleep disorder 18.33 13.79 36 94203 31652 34831040
Eyelash changes 18.22 13.79 5 94234 13 34862679
Ocular toxicity 18.11 13.79 10 94229 228 34862464
Acute respiratory distress syndrome 18.07 13.79 126 94113 25843 34836849
Accidental exposure to product 18.02 13.79 6 94233 12796 34849896
Lymphangiosis carcinomatosa 18.02 13.79 17 94222 915 34861777
Upper respiratory tract infection 17.90 13.79 39 94200 33020 34829672
Colony stimulating factor therapy 17.86 13.79 9 94230 169 34862523
Transient aphasia 17.86 13.79 12 94227 393 34862299
Duodenal ulcer perforation 17.81 13.79 22 94217 1610 34861082
Product administration error 17.80 13.79 11 94228 16333 34846359
Hepatic cancer recurrent 17.77 13.79 11 94228 312 34862380
Visceral venous thrombosis 17.70 13.79 5 94234 15 34862677
Therapy cessation 17.70 13.79 12 94227 16961 34845731
Blood triglycerides increased 17.68 13.79 8 94231 14151 34848541
Ectropion 17.68 13.79 8 94231 117 34862575
Viral infection 17.67 13.79 13 94226 17610 34845082
Hepatic failure 17.65 13.79 156 94083 34375 34828317
Perihepatic abscess 17.61 13.79 8 94231 118 34862574
Second primary malignancy 17.60 13.79 54 94185 7832 34854860
Anorectal discomfort 17.57 13.79 24 94215 1940 34860752
Trismus 17.25 13.79 27 94212 2468 34860224
Neurosarcoidosis 17.22 13.79 9 94230 183 34862509
Gastrooesophageal reflux disease 17.21 13.79 49 94190 37875 34824817
Superior vena cava syndrome 17.21 13.79 14 94225 617 34862075
Pelvic venous thrombosis 17.19 13.79 14 94225 618 34862074
Monocytopenia 17.16 13.79 7 94232 78 34862614
Osteoradionecrosis 17.16 13.79 7 94232 78 34862614
Hypersomnia 17.14 13.79 6 94233 12401 34850291
Renal salt-wasting syndrome 17.11 13.79 11 94228 334 34862358
Acute cutaneous lupus erythematosus 17.09 13.79 7 94232 79 34862613
Aplasia 17.02 13.79 38 94201 4550 34858142
Retroperitoneal abscess 17.00 13.79 9 94230 188 34862504
Hyperlipidaemia 16.94 13.79 9 94230 14520 34848172
Acute motor-sensory axonal neuropathy 16.92 13.79 8 94231 130 34862562
Intrahepatic portal hepatic venous fistula 16.91 13.79 4 94235 4 34862688
Papilloedema 16.90 13.79 28 94211 2685 34860007
Laboratory test abnormal 16.88 13.79 18 94221 20373 34842319
Peritoneal adhesions 16.86 13.79 8 94231 131 34862561
Sepsis 16.80 13.79 577 93662 165984 34696708
Lymph node abscess 16.80 13.79 5 94234 19 34862673
Therapeutic response unexpected 16.79 13.79 3 94236 9754 34852938
Movement disorder 16.79 13.79 6 94233 12242 34850450
Hepatitis B surface antigen positive 16.75 13.79 8 94231 133 34862559
Pulmonary hypertension 16.74 13.79 19 94220 20905 34841787
Non-cirrhotic portal hypertension 16.73 13.79 10 94229 266 34862426
Cataract 16.71 13.79 28 94211 26158 34836534
Aplastic anaemia 16.70 13.79 3 94236 9713 34852979
Rib fracture 16.67 13.79 9 94230 14391 34848301
Anaphylactic shock 16.65 13.79 86 94153 15855 34846837
Electrolyte imbalance 16.64 13.79 80 94159 14332 34848360
Bronchiolitis obliterans syndrome 16.62 13.79 9 94230 197 34862495
VIth nerve disorder 16.60 13.79 5 94234 20 34862672
Product quality issue 16.52 13.79 13 94226 17022 34845670
Hernia 16.38 13.79 3 94236 9580 34853112
Gastrointestinal stoma complication 16.36 13.79 19 94220 1303 34861389
Labelled drug-drug interaction medication error 16.35 13.79 10 94229 14929 34847763
Peritoneal disorder 16.30 13.79 10 94229 279 34862413
Suture rupture 16.24 13.79 11 94228 365 34862327
Unresponsive to stimuli 16.23 13.79 31 94208 27538 34835154
Eye pain 16.20 13.79 8 94231 13454 34849238
Bacterial colitis 16.14 13.79 6 94233 51 34862641
Full blood count decreased 16.09 13.79 15 94224 18073 34844619
Dysaesthesia 16.02 13.79 25 94214 2280 34860412
Bile duct stenosis 16.00 13.79 18 94221 1193 34861499
Pancreatic neuroendocrine tumour metastatic 15.93 13.79 7 94232 95 34862597
Catheter site extravasation 15.93 13.79 7 94232 95 34862597
Encapsulating peritoneal sclerosis 15.92 13.79 13 94226 576 34862116
Vascular device infection 15.91 13.79 35 94204 4150 34858542
Night sweats 15.90 13.79 14 94225 17338 34845354
Ear infection 15.86 13.79 4 94235 10227 34852465
Tubulointerstitial nephritis 15.85 13.79 20 94219 21004 34841688
Paraesthesia oral 15.84 13.79 35 94204 4162 34858530
Tetany 15.84 13.79 15 94224 811 34861881
Mechanical ileus 15.83 13.79 11 94228 381 34862311
Palpitations 15.80 13.79 55 94184 39931 34822761
Fatigue 15.79 13.79 1181 93058 369472 34493220
Electromyogram abnormal 15.75 13.79 6 94233 55 34862637
Cardiomyopathy 15.73 13.79 88 94151 16720 34845972
Medication error 15.71 13.79 28 94211 25537 34837155
Neuropathic muscular atrophy 15.70 13.79 5 94234 25 34862667
Radiation interaction 15.70 13.79 5 94234 25 34862667
K-ras gene mutation 15.70 13.79 5 94234 25 34862667
Eczema impetiginous 15.70 13.79 5 94234 25 34862667
Product substitution issue 15.55 13.79 4 94235 10091 34852601
Amnesia 15.52 13.79 30 94209 26533 34836159
Tooth disorder 15.49 13.79 5 94234 10877 34851815
Device related sepsis 15.49 13.79 29 94210 3064 34859628
Respiratory alkalosis 15.46 13.79 21 94218 1688 34861004
Metastases to pelvis 15.45 13.79 10 94229 307 34862385
Candida infection 15.44 13.79 91 94148 17624 34845068
Red blood cell sedimentation rate increased 15.38 13.79 3 94236 9159 34853533
Chimerism 15.24 13.79 9 94230 234 34862458
Cerebral haemorrhage 15.23 13.79 46 94193 34891 34827801
Therapy interrupted 15.22 13.79 9 94230 13688 34849004
Radiation skin injury 15.19 13.79 14 94225 731 34861961
Hypertensive crisis 15.15 13.79 55 94184 8696 34853996
Rectal ulcer 15.14 13.79 16 94223 988 34861704
Volvulus of small bowel 15.11 13.79 6 94233 62 34862630
Gastroenteritis radiation 15.09 13.79 10 94229 320 34862372
Proctectomy 15.01 13.79 7 94232 110 34862582
Duodenal stenosis 14.97 13.79 9 94230 242 34862450
Rash macular 14.90 13.79 8 94231 12834 34849858
Faeces discoloured 14.88 13.79 11 94228 14867 34847825
Guillain-Barre syndrome 14.84 13.79 43 94196 6044 34856648
Herpes simplex meningomyelitis 14.76 13.79 3 94236 0 34862692
Lip swelling 14.70 13.79 13 94226 16067 34846625
Aortitis 14.69 13.79 11 94228 429 34862263
Oesophageal irritation 14.62 13.79 6 94233 68 34862624
Intestinal mucosal hypertrophy 14.62 13.79 6 94233 68 34862624
Hypersplenism 14.51 13.79 11 94228 437 34862255
Rectal stenosis 14.50 13.79 8 94231 182 34862510
Neck pain 14.49 13.79 29 94210 25320 34837372
Toxic cardiomyopathy 14.45 13.79 9 94230 258 34862434
Stress ulcer 14.39 13.79 6 94233 71 34862621
Sarcoidosis 14.36 13.79 27 94212 2861 34859831
Metapneumovirus bronchiolitis 14.16 13.79 4 94235 12 34862680
Brain oedema 14.11 13.79 10 94229 13811 34848881
Necrotising colitis 14.08 13.79 16 94223 1072 34861620
COVID-19 pneumonia 14.02 13.79 15 94224 16952 34845740
Laryngeal pain 13.95 13.79 26 94213 2738 34859954
Rectal adenocarcinoma 13.94 13.79 14 94225 814 34861878
Axillary vein thrombosis 13.86 13.79 8 94231 199 34862493
B-cell small lymphocytic lymphoma 13.86 13.79 8 94231 199 34862493
Restlessness 13.85 13.79 30 94209 25452 34837240
Portal shunt 13.83 13.79 5 94234 39 34862653
Road traffic accident 13.79 13.79 16 94223 17434 34845258

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 3120.86 12.60 3285 151372 284425 79305306
Neuropathy peripheral 2183.34 12.60 1962 152695 139343 79450388
Diarrhoea 1662.32 12.60 4569 150088 875920 78713811
Mucosal inflammation 1612.03 12.60 1265 153392 74315 79515416
Dermatitis acneiform 1504.17 12.60 607 154050 9386 79580345
Disease progression 1478.46 12.60 1803 152854 182559 79407172
Skin toxicity 1138.58 12.60 472 154185 7842 79581889
Thrombocytopenia 1125.52 12.60 1917 152740 263342 79326389
Febrile neutropenia 993.48 12.60 1680 152977 229319 79360412
Palmar-plantar erythrodysaesthesia syndrome 980.27 12.60 676 153981 32458 79557273
Neurotoxicity 891.00 12.60 633 154024 31885 79557846
Arteriospasm coronary 861.65 12.60 364 154293 6352 79583379
Leukopenia 836.24 12.60 1079 153578 115434 79474297
Metastases to liver 718.16 12.60 526 154131 27788 79561943
Paronychia 680.87 12.60 323 154334 7485 79582246
Stomatitis 660.35 12.60 1090 153567 145667 79444064
Neoplasm progression 645.86 12.60 639 154018 51043 79538688
Malignant neoplasm progression 606.33 12.60 1006 153651 134984 79454747
Interstitial lung disease 550.94 12.60 869 153788 111731 79478000
Bone marrow failure 519.96 12.60 566 154091 50541 79539190
Polyneuropathy 496.58 12.60 396 154261 23755 79565976
Arthralgia 491.93 12.60 248 154409 571555 79018176
Peripheral sensory neuropathy 490.11 12.60 309 154348 12724 79577007
Vomiting 487.12 12.60 2558 152099 663270 78926461
Metastases to lung 482.32 12.60 347 154310 17816 79571915
Nausea 466.37 12.60 3308 151349 953888 78635843
Decreased appetite 463.31 12.60 1588 153069 340830 79248901
Cardiotoxicity 452.30 12.60 287 154370 11952 79577779
Myelosuppression 451.87 12.60 470 154187 39826 79549905
Gastrointestinal toxicity 449.15 12.60 247 154410 7862 79581869
Completed suicide 436.66 12.60 8 154649 245759 79343972
Hyperammonaemia 402.15 12.60 257 154400 10836 79578895
Joint swelling 380.35 12.60 54 154603 288592 79301139
Neutrophil count decreased 378.85 12.60 665 153992 93294 79496437
Rheumatoid arthritis 350.60 12.60 12 154645 208458 79381273
Proteinuria 330.59 12.60 360 154297 32142 79557589
Product dose omission issue 329.16 12.60 45 154612 247492 79342239
Haematotoxicity 324.43 12.60 257 154400 15262 79574469
Drug ineffective 312.89 12.60 1066 153591 1079847 78509884
Hypomagnesaemia 310.71 12.60 418 154239 46493 79543238
Headache 302.72 12.60 502 154155 653270 78936461
Drug abuse 286.06 12.60 6 154651 162685 79427046
Therapy partial responder 284.59 12.60 250 154407 17147 79572584
Weight increased 278.88 12.60 95 154562 277291 79312440
Hyperammonaemic encephalopathy 274.07 12.60 149 154508 4633 79585098
General physical health deterioration 266.88 12.60 1149 153508 274089 79315642
Gastrointestinal perforation 262.54 12.60 158 154499 5979 79583752
Dehydration 260.84 12.60 1062 153595 247125 79342606
Fall 256.02 12.60 343 154314 487286 79102445
Pain 248.08 12.60 632 154025 703170 78886561
Sinusitis 247.33 12.60 41 154616 195460 79394271
Therapeutic product effect decreased 245.56 12.60 19 154638 163844 79425887
Enteritis 245.45 12.60 213 154444 14370 79575361
Abdominal discomfort 244.95 12.60 90 154567 250637 79339094
Pyrexia 240.08 12.60 2183 152474 676526 78913205
Portal hypertension 229.09 12.60 153 154504 6955 79582776
Swelling 227.02 12.60 69 154588 216642 79373089
Pulmonary embolism 226.28 12.60 790 153867 170864 79418867
Peripheral swelling 225.33 12.60 121 154536 269496 79320235
Paraesthesia 225.14 12.60 803 153854 175520 79414211
Anaemia 223.34 12.60 1552 153105 443463 79146268
Asthenia 221.18 12.60 1722 152935 509967 79079764
Arthropathy 217.78 12.60 40 154617 177071 79412660
Nasopharyngitis 215.00 12.60 112 154545 253769 79335962
Acute myeloid leukaemia 214.95 12.60 282 154375 30603 79559128
Drug interaction 209.84 12.60 300 154357 414883 79174848
Pain in extremity 208.41 12.60 240 154417 364298 79225433
Systemic lupus erythematosus 207.12 12.60 6 154651 121143 79468588
Intestinal obstruction 206.02 12.60 329 154328 42691 79547040
Contraindicated product administered 199.33 12.60 33 154624 157505 79432226
Rash pustular 198.06 12.60 169 154488 11142 79578589
Metastases to lymph nodes 191.63 12.60 160 154497 10237 79579494
Contusion 188.60 12.60 31 154626 148745 79440986
Hypokalaemia 185.55 12.60 658 153999 143382 79446349
Colorectal cancer metastatic 185.54 12.60 75 154582 1163 79588568
Musculoskeletal stiffness 180.97 12.60 57 154600 174951 79414780
Product use issue 179.96 12.60 91 154566 209731 79380000
Injection site pain 178.81 12.60 21 154636 129817 79459914
Depression 177.16 12.60 100 154557 216690 79373041
Anxiety 176.83 12.60 134 154523 248378 79341353
Oesophageal fistula 167.44 12.60 54 154603 415 79589316
Abdominal pain 165.29 12.60 1306 153351 388263 79201468
Drug hypersensitivity 165.22 12.60 202 154455 298714 79291017
Extravasation 159.00 12.60 96 154561 3654 79586077
Chills 157.46 12.60 672 153985 159562 79430169
Pneumatosis intestinalis 155.75 12.60 116 154541 6281 79583450
Ileus 154.71 12.60 221 154436 25990 79563741
Intentional product misuse 151.56 12.60 8 154649 95157 79494574
Pemphigus 150.72 12.60 11 154646 99571 79490160
Posterior reversible encephalopathy syndrome 146.97 12.60 216 154441 26065 79563666
Carcinoembryonic antigen increased 146.86 12.60 76 154581 2133 79587598
Metastases to bone 145.71 12.60 207 154450 24220 79565511
Arthritis 145.45 12.60 24 154633 114856 79474875
Second primary malignancy 144.25 12.60 158 154499 14192 79575539
Large intestine perforation 144.02 12.60 159 154498 14408 79575323
Portal venous gas 141.24 12.60 46 154611 366 79589365
Influenza 137.98 12.60 40 154617 129566 79460165
Hypertransaminasaemia 137.07 12.60 141 154516 11783 79577948
Hepatic enzyme increased 137.02 12.60 93 154564 182517 79407214
Psoriatic arthropathy 136.58 12.60 3 154654 77996 79511735
Laryngospasm 136.00 12.60 89 154568 3908 79585823
Leukoencephalopathy 135.84 12.60 117 154540 7812 79581919
Glossodynia 134.43 12.60 20 154637 103317 79486414
Wheezing 133.76 12.60 31 154626 116633 79473098
Peritonitis 133.66 12.60 214 154443 27822 79561909
Insomnia 133.01 12.60 168 154489 245002 79344729
Focal nodular hyperplasia 132.41 12.60 51 154606 691 79589040
Intestinal perforation 132.07 12.60 166 154491 17260 79572471
Ascites 131.67 12.60 383 154274 75179 79514552
Acute promyelocytic leukaemia 130.95 12.60 62 154595 1429 79588302
Administration site extravasation 130.84 12.60 60 154597 1283 79588448
Metastases to peritoneum 128.74 12.60 89 154568 4283 79585448
Maternal exposure during pregnancy 128.31 12.60 52 154605 136486 79453245
Blood cholesterol increased 127.41 12.60 9 154648 83711 79506020
Cholangitis 127.26 12.60 140 154517 12636 79577095
Wound 127.14 12.60 34 154623 116145 79473586
Injury 125.04 12.60 6 154651 77490 79512241
Psoriasis 124.57 12.60 14 154643 89573 79500158
Septic shock 124.48 12.60 520 154137 122281 79467450
Asthma 124.45 12.60 53 154604 135042 79454689
Suicide attempt 123.14 12.60 10 154647 82922 79506809
Discomfort 122.75 12.60 45 154612 125572 79464159
Treatment failure 122.42 12.60 91 154566 170395 79419336
Hospitalisation 120.84 12.60 19 154638 94217 79495514
Migraine 120.84 12.60 14 154643 87479 79502252
Cardiomyopathy 120.23 12.60 207 154450 28567 79561164
Venoocclusive liver disease 119.00 12.60 130 154527 11641 79578090
Mobility decreased 118.99 12.60 44 154613 122131 79467600
Subileus 118.95 12.60 94 154563 5560 79584171
Non-cirrhotic portal hypertension 118.33 12.60 42 154615 445 79589286
Acute coronary syndrome 117.17 12.60 173 154484 20960 79568771
Chronic obstructive pulmonary disease 117.14 12.60 14 154643 85405 79504326
Rhabdomyolysis 117.06 12.60 28 154629 103103 79486628
Mucosal toxicity 117.01 12.60 44 154613 556 79589175
Condition aggravated 115.74 12.60 539 154118 500585 79089146
Drug intolerance 115.28 12.60 210 154447 263909 79325822
Neutropenic sepsis 114.79 12.60 196 154461 26868 79562863
Intentional product use issue 114.74 12.60 77 154580 152035 79437696
Hiccups 114.20 12.60 118 154539 9913 79579818
Neutropenic colitis 113.92 12.60 92 154565 5615 79584116
Dizziness 113.63 12.60 580 154077 525861 79063870
Electrocardiogram ST segment elevation 112.64 12.60 108 154549 8289 79581442
Skin reaction 112.24 12.60 147 154510 15921 79573810
Osteoarthritis 111.06 12.60 18 154639 87291 79502440
Stress cardiomyopathy 110.60 12.60 122 154535 11044 79578687
Helicobacter infection 110.55 12.60 6 154651 69698 79520033
Hyperbilirubinaemia 108.55 12.60 181 154476 24337 79565394
Suicidal ideation 108.52 12.60 11 154646 76329 79513402
Anastomotic leak 108.23 12.60 49 154608 1016 79588715
Lower respiratory tract infection 107.85 12.60 58 154599 129162 79460569
Tumour necrosis 107.68 12.60 59 154598 1863 79587868
Ejection fraction decreased 107.32 12.60 219 154438 34358 79555373
Device related thrombosis 106.88 12.60 66 154591 2617 79587114
Irritable bowel syndrome 106.67 12.60 3 154654 62238 79527493
Stress 104.49 12.60 15 154642 79597 79510134
Somnolence 104.29 12.60 190 154467 238791 79350940
Overdose 103.28 12.60 123 154534 184083 79405648
Bronchitis 102.81 12.60 63 154594 130581 79459150
Loss of personal independence in daily activities 101.49 12.60 36 154621 102544 79487187
Device related infection 100.34 12.60 212 154445 34082 79555649
Dermatitis 99.25 12.60 161 154496 21160 79568571
Epistaxis 99.12 12.60 454 154203 111061 79478670
Colitis 98.75 12.60 340 154317 72967 79516764
Feeling abnormal 98.43 12.60 98 154559 159101 79430630
Toxic leukoencephalopathy 98.34 12.60 47 154610 1107 79588624
Tumour perforation 97.35 12.60 35 154622 386 79589345
White blood cell count decreased 96.69 12.60 661 153996 187627 79402104
Blister 96.29 12.60 56 154601 119420 79470311
Splenomegaly 95.63 12.60 156 154501 20598 79569133
Injection site erythema 95.35 12.60 18 154639 78179 79511552
Cholinergic syndrome 94.85 12.60 45 154612 1042 79588689
Small intestinal obstruction 92.17 12.60 179 154478 27093 79562638
Aorto-oesophageal fistula 91.57 12.60 23 154634 59 79589672
Pelvic abscess 91.07 12.60 55 154602 2094 79587637
Nodular regenerative hyperplasia 90.98 12.60 47 154610 1314 79588417
Confusional state 89.72 12.60 316 154341 317681 79272050
Pneumonia 87.83 12.60 838 153819 659408 78930323
Rectal perforation 86.81 12.60 40 154617 865 79588866
Tumour lysis syndrome 85.68 12.60 161 154496 23778 79565953
Memory impairment 85.01 12.60 56 154601 111678 79478053
Drug reaction with eosinophilia and systemic symptoms 84.55 12.60 12 154645 64232 79525499
Exposure during pregnancy 83.50 12.60 46 154611 101086 79488645
Fluid retention 83.16 12.60 17 154640 69792 79519939
Large intestinal obstruction 82.96 12.60 61 154596 3238 79586493
Dry skin 82.71 12.60 305 154352 67690 79522041
Ileal perforation 82.07 12.60 40 154617 985 79588746
Aggression 82.03 12.60 4 154653 50954 79538777
Aortic thrombosis 81.32 12.60 47 154610 1648 79588083
Gastrointestinal necrosis 81.20 12.60 75 154582 5490 79584241
Urticaria 80.11 12.60 148 154509 185053 79404678
Disseminated intravascular coagulation 79.88 12.60 199 154458 35643 79554088
Skin fissures 79.76 12.60 112 154545 12961 79576770
Myalgia 79.72 12.60 149 154508 185492 79404239
Incorrect dose administered 79.10 12.60 25 154632 76605 79513126
COVID-19 78.44 12.60 115 154542 157559 79432172
Deep vein thrombosis 77.95 12.60 450 154207 120469 79469262
Electrocardiogram QT prolonged 77.74 12.60 39 154618 90347 79499384
Pruritus 75.64 12.60 452 154205 394196 79195535
Intravascular haemolysis 74.39 12.60 35 154622 795 79588936
Hallucination 73.74 12.60 37 154620 85708 79504023
Dihydropyrimidine dehydrogenase deficiency 73.46 12.60 22 154635 128 79589603
Duodenal ulcer perforation 73.14 12.60 19 154638 66192 79523539
Venous thrombosis 72.65 12.60 79 154578 7037 79582694
Hepatic lesion 72.34 12.60 78 154579 6881 79582850
Injection site swelling 71.90 12.60 5 154652 47127 79542604
Blood pressure fluctuation 70.94 12.60 21 154636 67124 79522607
Pericarditis 70.56 12.60 59 154598 104177 79485554
Nasal congestion 70.54 12.60 30 154627 76522 79513209
Injection site reaction 70.33 12.60 11 154646 54774 79534957
Enterocutaneous fistula 70.00 12.60 45 154612 1916 79587815
Dysgeusia 69.98 12.60 257 154400 56920 79532811
Embolism 69.78 12.60 109 154548 13873 79575858
Red blood cell sedimentation rate increased 69.72 12.60 5 154652 45937 79543794
Recall phenomenon 69.55 12.60 37 154620 1100 79588631
Vena cava thrombosis 69.37 12.60 52 154605 2843 79586888
Left ventricular dysfunction 69.02 12.60 130 154527 19231 79570500
Necrotising fasciitis 68.56 12.60 71 154586 5979 79583752
Sedation 67.58 12.60 10 154647 51885 79537846
Trichomegaly 67.42 12.60 20 154637 112 79589619
Heart rate decreased 67.32 12.60 26 154631 70290 79519441
Gait disturbance 66.29 12.60 195 154462 207311 79382420
Subacute cutaneous lupus erythematosus 66.03 12.60 55 154602 3506 79586225
Type 2 diabetes mellitus 65.82 12.60 15 154642 57107 79532624
Febrile bone marrow aplasia 65.67 12.60 102 154555 12918 79576813
Acute abdomen 65.66 12.60 52 154605 3085 79586646
Hyperthermia 65.41 12.60 122 154535 17915 79571816
Anastomotic complication 65.40 12.60 27 154630 443 79589288
Oesophagitis 65.17 12.60 145 154512 24144 79565587
Adverse drug reaction 64.48 12.60 24 154633 66368 79523363
Nicotinic acid deficiency 64.05 12.60 21 154636 171 79589560
Treatment noncompliance 63.79 12.60 12 154645 52256 79537475
Bradycardia 63.47 12.60 103 154554 135454 79454277
Thrombocytopenic purpura 62.87 12.60 46 154611 2423 79587308
Illness 62.85 12.60 8 154649 46503 79543228
Metastasis 62.72 12.60 72 154585 6808 79582923
Colony stimulating factor therapy 62.57 12.60 27 154630 497 79589234
Dysphagia 62.20 12.60 428 154229 121708 79468023
Balance disorder 62.08 12.60 60 154597 98797 79490934
C-reactive protein abnormal 61.44 12.60 10 154647 48357 79541374
Liver abscess 61.44 12.60 67 154590 5987 79583744
Sepsis 60.98 12.60 794 153863 268634 79321097
Blood pressure increased 60.94 12.60 208 154449 211152 79378579
Anastomotic fistula 60.70 12.60 19 154638 131 79589600
Ocular toxicity 60.56 12.60 31 154626 850 79588881
Blood pressure systolic increased 60.53 12.60 27 154630 66959 79522772
Sleep disorder 59.86 12.60 47 154610 85630 79504101
Dysentery 59.45 12.60 34 154623 1168 79588563
Plasma cell myeloma 59.37 12.60 15 154642 53244 79536487
Emotional distress 58.83 12.60 5 154652 39964 79549767
Cough 58.78 12.60 443 154214 366346 79223385
Vasospasm 58.58 12.60 33 154624 1101 79588630
Enterocolitis 57.50 12.60 102 154555 14410 79575321
Aortitis 57.32 12.60 36 154621 1471 79588260
Xerosis 56.69 12.60 33 154624 1173 79588558
Hypophagia 56.43 12.60 205 154452 45162 79544569
Congestive cardiomyopathy 56.25 12.60 90 154567 11690 79578041
Intestinal ischaemia 56.13 12.60 96 154561 13174 79576557
Obesity 55.77 12.60 3 154654 35122 79554609
Carbohydrate antigen 19-9 increased 55.66 12.60 24 154633 441 79589290
Respiratory arrest 55.56 12.60 21 154636 57529 79532202
Dysarthria 55.46 12.60 269 154388 67353 79522378
Metastases to skin 55 12.60 37 154620 1702 79588029
Portal vein thrombosis 54.85 12.60 62 154595 5765 79583966
Hypoalbuminaemia 54.75 12.60 125 154532 21172 79568559
Skin disorder 54.33 12.60 167 154490 33776 79555955
Haemolytic anaemia 54.27 12.60 112 154545 17708 79572023
Subclavian vein thrombosis 54.18 12.60 42 154615 2415 79587316
Oesophageal stenosis 52.80 12.60 53 154604 4301 79585430
Biliary tract infection 52.40 12.60 33 154624 1355 79588376
Pulmonary artery thrombosis 52.31 12.60 33 154624 1359 79588372
Duodenal perforation 52.01 12.60 39 154618 2133 79587598
Small intestinal perforation 51.17 12.60 46 154611 3251 79586480
Conjunctival filtering bleb leak 50.87 12.60 12 154645 21 79589710
Oesophagobronchial fistula 50.75 12.60 19 154638 237 79589494
Adenocarcinoma 50.27 12.60 49 154608 3837 79585894
Colon cancer recurrent 50.07 12.60 16 154641 119 79589612
Metastases to central nervous system 49.96 12.60 103 154554 16272 79573459
Sleep apnoea syndrome 49.96 12.60 6 154651 36472 79553259
Upper respiratory tract infection 49.88 12.60 62 154595 91106 79498625
Toxicity to various agents 49.76 12.60 550 154107 420990 79168741
Dysphonia 49.37 12.60 230 154427 56642 79533089
Drug withdrawal syndrome 49.34 12.60 5 154652 34713 79555018
Conjunctivitis 49.33 12.60 135 154522 25580 79564151
Jugular vein thrombosis 49.18 12.60 52 154605 4486 79585245
Gastrooesophageal reflux disease 48.99 12.60 79 154578 104167 79485564
Blood glucose increased 48.71 12.60 93 154564 114882 79474849
Drug level increased 48.61 12.60 9 154648 39642 79550089
Tremor 48.60 12.60 168 154489 169915 79419816
Immune thrombocytopenia 48.56 12.60 107 154550 17698 79572033
International normalised ratio increased 48.07 12.60 56 154601 84665 79505066
Cachexia 47.97 12.60 81 154576 11002 79578729
Colon cancer metastatic 47.48 12.60 37 154620 2144 79587587
Psychotic disorder 47.45 12.60 11 154646 41391 79548340
Varices oesophageal 46.88 12.60 58 154599 5933 79583798
Joint range of motion decreased 46.77 12.60 5 154652 33277 79556454
Heart rate increased 46.61 12.60 103 154554 120621 79469110
Unevaluable event 46.29 12.60 25 154632 55560 79534171
Adverse event 46.03 12.60 30 154627 60184 79529547
Prinzmetal angina 45.97 12.60 33 154624 1687 79588044
Proctalgia 45.84 12.60 75 154582 9926 79579805
Palpitations 45.69 12.60 112 154545 126498 79463233
Troponin I increased 45.60 12.60 51 154606 4687 79585044
Prescribed underdose 45.40 12.60 3 154654 29511 79560220
Cardiac failure congestive 45.33 12.60 134 154523 142268 79447463
Hypertensive crisis 44.89 12.60 114 154543 20656 79569075
Aplasia 44.77 12.60 65 154592 7755 79581976
Bacterial translocation 44.65 12.60 23 154634 639 79589092
Metastases to ovary 44.62 12.60 19 154638 338 79589393
Acral peeling skin syndrome 44.57 12.60 12 154645 44 79589687
Nephrolithiasis 44.33 12.60 24 154633 53267 79536464
Breast cancer metastatic 44.24 12.60 68 154589 8534 79581197
Odynophagia 44.09 12.60 79 154578 11248 79578483
Growth of eyelashes 44.06 12.60 16 154641 182 79589549
Metastases to meninges 43.97 12.60 44 154613 3557 79586174
Hypervolaemia 43.93 12.60 14 154643 42676 79547055
Muscle spasms 43.82 12.60 182 154475 174548 79415183
Inappropriate schedule of product administration 43.81 12.60 124 154533 133504 79456227
Steatohepatitis 43.67 12.60 26 154631 964 79588767
Joint injury 43.29 12.60 5 154652 31330 79558401
Renal salt-wasting syndrome 42.96 12.60 23 154634 693 79589038
Agitation 42.82 12.60 80 154577 99635 79490096
Stoma site haemorrhage 42.79 12.60 33 154624 1883 79587848
Pelvic fluid collection 42.76 12.60 24 154633 795 79588936
Night sweats 42.56 12.60 24 154633 52071 79537660
Injection site haemorrhage 42.39 12.60 3 154654 27867 79561864
Hyperkalaemia 42.22 12.60 100 154557 114298 79475433
Hepatic failure 42.20 12.60 232 154425 60980 79528751
Full blood count abnormal 42.13 12.60 13 154644 40461 79549270
Pancytopenia 42.00 12.60 499 154158 165246 79424485
Encapsulating peritoneal sclerosis 41.90 12.60 24 154633 827 79588904
Enterovesical fistula 41.88 12.60 27 154630 1155 79588576
Ear infection 41.81 12.60 8 154649 34424 79555307
Neoplasm recurrence 41.66 12.60 46 154611 4168 79585563
Gastric perforation 41.53 12.60 45 154612 3992 79585739
Fistula 41.39 12.60 83 154574 12857 79576874
Cellulitis 41.32 12.60 94 154563 108966 79480765
Joint stiffness 40.94 12.60 14 154643 40816 79548915
Transdifferentiation of neoplasm 40.88 12.60 13 154644 95 79589636
Head injury 40.75 12.60 11 154646 37358 79552373
Herpes zoster 40.57 12.60 74 154583 93009 79496722
Withdrawal syndrome 40.53 12.60 3 154654 26851 79562880
Systemic infection 40.53 12.60 70 154587 9682 79580049
Productive cough 40.52 12.60 68 154589 88263 79501468
Type II hypersensitivity 40.51 12.60 11 154646 42 79589689
Metastases to chest wall 39.87 12.60 20 154637 525 79589206
Eosinophilia 39.85 12.60 19 154638 45326 79544405
Metastases to pleura 39.67 12.60 29 154628 1525 79588206
Underdose 39.63 12.60 8 154649 33143 79556588
Venous thrombosis limb 39.55 12.60 46 154611 4411 79585320
Myocardial infarction 39.52 12.60 203 154454 183926 79405805
Lung neoplasm malignant 39.51 12.60 4 154653 27788 79561943
Liver function test abnormal 39.48 12.60 40 154617 64435 79525296
Viral infection 39.40 12.60 17 154640 42999 79546732
Medication error 39.34 12.60 45 154612 68597 79521134
Adenocarcinoma of colon 39.17 12.60 51 154606 5490 79584241
Road traffic accident 38.82 12.60 18 154639 43646 79546085
Gene mutation 38.80 12.60 36 154621 2650 79587081
Osteoporosis 38.67 12.60 29 154628 54083 79535648
Wrong technique in product usage process 38.60 12.60 52 154605 73823 79515908
Drug ineffective for unapproved indication 38.53 12.60 26 154631 51212 79538519
Bursitis 38.25 12.60 11 154646 35833 79553898
Superior vena cava syndrome 38.13 12.60 26 154631 1223 79588508
Haemolytic uraemic syndrome 37.96 12.60 45 154612 4404 79585327
Vision blurred 37.95 12.60 94 154563 105804 79483927
Gait inability 37.87 12.60 35 154622 58882 79530849
Metastases to the mediastinum 37.74 12.60 20 154637 590 79589141
Poisoning 37.64 12.60 3 154654 25269 79564462
Coronary artery disease 37.44 12.60 43 154614 65431 79524300
Gastrointestinal stoma complication 37.43 12.60 35 154622 2602 79587129
Dysaesthesia 37.02 12.60 51 154606 5797 79583934
Malignant ascites 36.84 12.60 25 154632 1167 79588564
Gastrointestinal anastomotic leak 36.79 12.60 19 154638 531 79589200
Balanoposthitis 36.47 12.60 23 154634 947 79588784
Cataract 36.39 12.60 40 154617 62080 79527651
Tumour ulceration 36.34 12.60 15 154642 246 79589485
Nephrotic syndrome 36.13 12.60 72 154585 11102 79578629
Hypoglycaemia 35.77 12.60 91 154566 101503 79488228
Cardiac disorder 35.68 12.60 45 154612 65712 79524019
Hypertension 35.38 12.60 866 153791 330126 79259605
Pregnancy 35.37 12.60 5 154652 26846 79562885
Factor VII deficiency 35.31 12.60 9 154648 25 79589706
Rib fracture 35.00 12.60 6 154651 27941 79561790
Oesophageal perforation 34.96 12.60 27 154630 1544 79588187
Radiation skin injury 34.90 12.60 26 154631 1408 79588323
Hepatitis B 34.88 12.60 60 154597 8272 79581459
White blood cell count abnormal 34.72 12.60 49 154608 5696 79584035
Fistula of small intestine 34.62 12.60 21 154636 806 79588925
Accidental exposure to product 34.57 12.60 9 154648 31313 79558418
K-ras gene mutation 34.49 12.60 10 154647 51 79589680
Cytomegalovirus infection 34.33 12.60 20 154637 42624 79547107
Therapy cessation 34.15 12.60 15 154642 37547 79552184
Abnormal behaviour 33.99 12.60 14 154643 36407 79553324
Performance status decreased 33.82 12.60 50 154607 6063 79583668
Sopor 33.66 12.60 11 154646 32999 79556732
Splenic artery thrombosis 33.42 12.60 10 154647 58 79589673
Short-bowel syndrome 33.36 12.60 18 154639 551 79589180
Anal haemorrhage 33.15 12.60 41 154616 4193 79585538
Right ventricular ejection fraction decreased 32.99 12.60 10 154647 61 79589670
Rectal haemorrhage 32.88 12.60 257 154400 76043 79513688
Agranulocytosis 32.62 12.60 173 154484 44857 79544874
Sinus disorder 32.55 12.60 3 154654 22461 79567270
Encephalopathy 32.43 12.60 233 154424 67164 79522567
Anal erythema 32.25 12.60 13 154644 200 79589531
Tumour haemorrhage 32.23 12.60 40 154617 4104 79585627
Irritability 32.13 12.60 20 154637 41124 79548607
Blood creatine phosphokinase increased 32.08 12.60 49 154608 66041 79523690
Abdominal abscess 32.06 12.60 53 154604 7074 79582657
Cystitis 31.96 12.60 33 154624 52699 79537032
Cytokine release syndrome 31.76 12.60 15 154642 35983 79553748
Peripheral sensorimotor neuropathy 31.75 12.60 34 154623 2976 79586755
Platelet count decreased 31.61 12.60 542 154115 194122 79395609
Hypovolaemic shock 31.49 12.60 72 154585 12204 79577527
Pneumonitis 31.40 12.60 214 154443 60646 79529085
Amnesia 31.33 12.60 46 154611 63011 79526720
Rectal tenesmus 31.33 12.60 26 154631 1649 79588082
Tumour marker increased 31.27 12.60 40 154617 4232 79585499
Localised infection 31.14 12.60 17 154640 37558 79552173
Nail disorder 30.95 12.60 70 154587 11782 79577949
Mental disorder 30.93 12.60 11 154646 31291 79558440
Oral pain 30.91 12.60 133 154524 31665 79558066
Thrombotic thrombocytopenic purpura 30.84 12.60 49 154608 6327 79583404
Refeeding syndrome 30.77 12.60 10 154647 79 79589652
Muscle spasticity 30.76 12.60 3 154654 21472 79568259
Musculoskeletal pain 30.66 12.60 99 154558 102255 79487476
Electrolyte imbalance 30.66 12.60 130 154527 30751 79558980
Rectal cancer metastatic 30.57 12.60 16 154641 460 79589271
Poor quality sleep 30.48 12.60 4 154653 22718 79567013
Perineal disorder 30.45 12.60 8 154649 26 79589705
Astringent therapy 30.45 12.60 8 154649 26 79589705
Hypercreatinaemia 30.33 12.60 14 154643 304 79589427
Ischaemic stroke 30.24 12.60 136 154521 32995 79556736
Product quality issue 30.16 12.60 14 154643 33926 79555805
Erythema 30.11 12.60 604 154053 222686 79367045
Tracheal stenosis 30.03 12.60 15 154642 390 79589341
Oesophageal varices haemorrhage 29.96 12.60 39 154618 4197 79585534
Accidental overdose 29.87 12.60 20 154637 39561 79550170
Limb injury 29.82 12.60 10 154647 29518 79560213
Multiple sclerosis 29.70 12.60 4 154653 22278 79567453
Product prescribing error 29.55 12.60 26 154631 44787 79544944
Chronic myeloid leukaemia 29.52 12.60 36 154621 3628 79586103
Hepatectomy 29.51 12.60 12 154645 189 79589542
Stridor 29.31 12.60 44 154613 5409 79584322
Prostate cancer 29.14 12.60 14 154643 33254 79556477
Miller Fisher syndrome 29.10 12.60 13 154644 261 79589470
Sciatica 29.07 12.60 14 154643 33208 79556523
Neutrophil count abnormal 28.99 12.60 35 154622 3491 79586240
Diaphragmatic paralysis 28.95 12.60 21 154636 1091 79588640
Urinary tract infection 28.95 12.60 367 154290 274145 79315586
Kidney infection 28.94 12.60 4 154653 21847 79567884
Hepatic atrophy 28.82 12.60 15 154642 426 79589305
Myoclonus 28.58 12.60 9 154648 27651 79562080
Neck pain 28.57 12.60 65 154592 75352 79514379
Cytomegalovirus oesophagitis 28.52 12.60 18 154639 742 79588989
Angioedema 28.43 12.60 66 154591 75969 79513762
Wrong rate 28.39 12.60 9 154648 65 79589666
Foot deformity 28.38 12.60 6 154651 24068 79565663
Diffuse alveolar damage 28.37 12.60 35 154622 3569 79586162
Disturbance in attention 28.36 12.60 34 154623 50767 79538964
Hallucination, visual 28.32 12.60 14 154643 32715 79557016
Wound dehiscence 28.28 12.60 48 154609 6547 79583184
Musculoskeletal disorder 28.23 12.60 4 154653 21444 79568287
Muscular weakness 28.20 12.60 189 154468 160540 79429191
Portal shunt 28.15 12.60 9 154648 67 79589664
Gastric disorder 28.14 12.60 19 154638 37414 79552317
Atypical haemolytic uraemic syndrome 28.04 12.60 20 154637 1012 79588719
Anorectal disorder 27.97 12.60 28 154629 2265 79587466
Bacteraemia 27.94 12.60 132 154525 32692 79557039
Nephritis bacterial 27.89 12.60 8 154649 39 79589692
Induration 27.89 12.60 26 154631 1926 79587805
Musculoskeletal discomfort 27.82 12.60 3 154654 19832 79569899
Jaundice 27.76 12.60 188 154469 53161 79536570
Therapy interrupted 27.74 12.60 13 154644 31328 79558403
Chronic kidney disease 27.59 12.60 54 154603 66100 79523631
Cell-mediated cytotoxicity 27.40 12.60 8 154649 42 79589689
Infusion related hypersensitivity reaction 27.38 12.60 14 154643 383 79589348
Back pain 27.33 12.60 420 154237 303760 79285971
Eye disorder 27.27 12.60 6 154651 23406 79566325
Bladder cancer 27.27 12.60 3 154654 19523 79570208
Sciatic nerve palsy 27.06 12.60 9 154648 77 79589654
Haematoma 27.00 12.60 37 154620 52158 79537573
Visual impairment 26.98 12.60 90 154567 92041 79497690
Protein urine 26.91 12.60 23 154634 1519 79588212
Pain in jaw 26.72 12.60 30 154627 46121 79543610
Venous pressure jugular decreased 26.56 12.60 9 154648 82 79589649
Pulmonary infarction 26.55 12.60 35 154622 3814 79585917
Ill-defined disorder 26.42 12.60 55 154602 65820 79523911
Koebner phenomenon 26.37 12.60 8 154649 49 79589682
NPM1 gene mutation 26.34 12.60 10 154647 130 79589601
Cystitis radiation 26.24 12.60 11 154646 188 79589543
Movement disorder 26.22 12.60 10 154647 27249 79562482
Oesophageal haemorrhage 26.14 12.60 24 154633 1743 79587988
Dyskinesia 26.04 12.60 29 154628 44744 79544987
Extrapyramidal disorder 26.04 12.60 6 154651 22673 79567058
Injection site mass 26.03 12.60 4 154653 20180 79569551
Myocarditis 26.01 12.60 97 154560 21636 79568095
Pulmonary toxicity 25.98 12.60 69 154588 12845 79576886
VIth nerve disorder 25.93 12.60 7 154650 26 79589705
Laryngeal oedema 25.83 12.60 52 154605 8077 79581654
Stomal varices 25.73 12.60 9 154648 91 79589640
Lymphangiosis carcinomatosa 25.72 12.60 26 154631 2128 79587603
Organising pneumonia 25.71 12.60 62 154595 10877 79578854
Metastases to pelvis 25.65 12.60 16 154641 646 79589085
Pigmentation disorder 25.57 12.60 42 154615 5576 79584155
Tumour fistulisation 25.52 12.60 7 154650 28 79589703
Diabetes mellitus 25.50 12.60 73 154584 78317 79511414
Rash pruritic 25.34 12.60 64 154593 71565 79518166
Proctitis 25.21 12.60 45 154612 6387 79583344
Pharyngeal dyskinesia 25.21 12.60 8 154649 58 79589673
Respiratory disorder 25.07 12.60 30 154627 44826 79544905
Nervousness 25.06 12.60 17 154640 33398 79556333
Swelling face 24.90 12.60 64 154593 71148 79518583
Fear 24.88 12.60 6 154651 21980 79567751
Neuromyotonia 24.81 12.60 9 154648 102 79589629
Guillain-Barre syndrome 24.59 12.60 54 154603 8911 79580820
Ventricular hypokinesia 24.45 12.60 55 154602 9224 79580507
PIK3CA-activated mutation 24.44 12.60 15 154642 588 79589143
Tongue oedema 24.39 12.60 47 154610 7070 79582661
Device issue 24.37 12.60 11 154646 27097 79562634
Lip swelling 24.35 12.60 26 154631 40885 79548846
Chemotherapy 24.33 12.60 23 154634 1734 79587997
Hypoferritinaemia 24.29 12.60 6 154651 14 79589717
Mood altered 24.28 12.60 3 154654 17844 79571887
Perforation bile duct 24.26 12.60 7 154650 35 79589696
Retroperitoneal abscess 24.09 12.60 13 154644 398 79589333
No adverse event 24.02 12.60 22 154635 37170 79552561
Portal vein embolisation 24.00 12.60 6 154651 15 79589716
Gout 23.94 12.60 9 154648 24740 79564991
Full blood count decreased 23.93 12.60 11 154646 26808 79562923
Incorrect drug administration rate 23.83 12.60 34 154623 3992 79585739
Myelodysplastic syndrome 23.74 12.60 119 154538 30182 79559549
Toxic erythema of chemotherapy 23.62 12.60 11 154646 244 79589487
Ectropion 23.60 12.60 13 154644 415 79589316
Breast cancer recurrent 23.58 12.60 29 154628 2948 79586783
Nasal septum perforation 23.50 12.60 16 154641 751 79588980
Impaired healing 23.42 12.60 89 154568 87566 79502165
Necrotising colitis 23.42 12.60 18 154639 1022 79588709
Sinus congestion 23.37 12.60 5 154652 19891 79569840
Metastatic neoplasm 23.36 12.60 38 154619 5004 79584727
Hiatus hernia 23.36 12.60 8 154649 23304 79566427
Thrombotic microangiopathy 23.29 12.60 89 154568 20080 79569651
Systemic scleroderma 23.27 12.60 19 154638 1178 79588553
Evans syndrome 23.23 12.60 13 154644 428 79589303
Anger 23.07 12.60 3 154654 17159 79572572
Haemoglobinuria 23.05 12.60 16 154641 775 79588956
Blood glucose decreased 23.04 12.60 11 154646 26223 79563508
Disability 22.99 12.60 3 154654 17117 79572614
Acute interstitial pneumonitis 22.91 12.60 19 154638 1204 79588527
Oedema peripheral 22.77 12.60 348 154309 251940 79337791
Acute respiratory distress syndrome 22.76 12.60 155 154502 43912 79545819
Nail toxicity 22.74 12.60 12 154645 351 79589380
Mucocutaneous rash 22.65 12.60 7 154650 46 79589685
Anal erosion 22.65 12.60 7 154650 46 79589685
Hormone receptor positive breast cancer 22.61 12.60 12 154645 355 79589376
Pneumoperitoneum 22.59 12.60 29 154628 3079 79586652
Hypocalcaemia 22.54 12.60 170 154487 49754 79539977
Proteus infection 22.47 12.60 24 154633 2094 79587637
Delusion 22.29 12.60 6 154651 20417 79569314
Eye pain 22.23 12.60 24 154633 37554 79552177
Labelled drug-drug interaction medication error 22.21 12.60 13 154644 27637 79562094
Dysaesthesia pharynx 22.10 12.60 10 154647 207 79589524
Parkinsonism 22.05 12.60 3 154654 16581 79573150
Colitis ulcerative 21.90 12.60 21 154636 34721 79555010
Gastrointestinal ischaemia 21.79 12.60 13 154644 484 79589247
Prothrombin level decreased 21.78 12.60 21 154636 1623 79588108
Restless legs syndrome 21.74 12.60 6 154651 20086 79569645
Seasonal allergy 21.74 12.60 3 154654 16403 79573328
Laryngeal pain 21.73 12.60 41 154616 6073 79583658
Biliary fistula 21.57 12.60 8 154649 97 79589634
Peritoneal neoplasm 21.50 12.60 8 154649 98 79589633
Live birth 21.44 12.60 5 154652 18739 79570992
Product storage error 21.42 12.60 3 154654 16223 79573508
Therapy non-responder 21.39 12.60 99 154558 92206 79497525
Procedural pain 21.34 12.60 9 154648 23075 79566656
Rash macular 21.28 12.60 15 154642 28884 79560847
Radiation interaction 21.14 12.60 7 154650 59 79589672
Eczema impetiginous 21.13 12.60 6 154651 28 79589703
Microgenia 21.11 12.60 5 154652 9 79589722
Obstructive airways disorder 21.05 12.60 18 154639 31441 79558290
Onycholysis 21.05 12.60 23 154634 2060 79587671
Cardiac arrest 20.88 12.60 223 154434 171873 79417858
Diaphragmatic operation 20.79 12.60 6 154651 30 79589701
Liver function test increased 20.77 12.60 28 154629 39745 79549986
Ischiorectal hernia 20.76 12.60 5 154652 10 79589721
Aphthous ulcer 20.73 12.60 76 154581 16813 79572918
Radiation mucositis 20.71 12.60 10 154647 241 79589490
Spinal stenosis 20.66 12.60 3 154654 15788 79573943
Renal disorder 20.64 12.60 31 154626 42074 79547657
Hernia 20.64 12.60 4 154653 17055 79572676
Interventricular septum rupture 20.63 12.60 6 154651 31 79589700
Metastases to spine 20.60 12.60 33 154624 4291 79585440
Intervertebral disc protrusion 20.60 12.60 10 154647 23611 79566120
Pseudocirrhosis 20.39 12.60 14 154643 666 79589065
Influenza like illness 20.35 12.60 71 154586 71636 79518095
Faeces discoloured 20.31 12.60 16 154641 29111 79560620
Gastrointestinal inflammation 20.19 12.60 45 154612 7499 79582232
Lymphadenopathy mediastinal 20.19 12.60 33 154624 4363 79585368
Anaemia of malignant disease 20.17 12.60 15 154642 810 79588921
Hypertrichosis 20.12 12.60 18 154639 1264 79588467
Tympanic membrane disorder 20.08 12.60 9 154648 182 79589549
Creatinine renal clearance decreased 19.97 12.60 6 154651 18996 79570735
Clostridial infection 19.91 12.60 38 154619 5676 79584055
Depilation 19.86 12.60 5 154652 13 79589718
Pancreatic neuroendocrine tumour metastatic 19.85 12.60 8 154649 123 79589608
Subdural haematoma 19.82 12.60 19 154638 31415 79558316
Pneumonitis chemical 19.80 12.60 12 154645 460 79589271
Hypersomnia 19.79 12.60 10 154647 23076 79566655
Crying 19.72 12.60 10 154647 23033 79566698
Transient aphasia 19.61 12.60 12 154645 468 79589263
Rectosigmoid cancer 19.57 12.60 10 154647 273 79589458
Gastroenteritis radiation 19.50 12.60 14 154643 716 79589015
Pachymeningitis 19.48 12.60 10 154647 276 79589455
Intracardiac thrombus 19.41 12.60 32 154625 4261 79585470
Peritoneal disorder 19.41 12.60 14 154643 721 79589010
Limb discomfort 19.41 12.60 21 154636 32829 79556902
Hyperpyrexia 19.39 12.60 39 154618 6053 79583678
Blood pressure diastolic decreased 19.36 12.60 18 154639 30198 79559533
Hydronephrosis 19.32 12.60 76 154581 17378 79572353
Sneezing 19.30 12.60 7 154650 19676 79570055
Anal fistula 19.24 12.60 42 154615 6902 79582829
Pulmonary fibrosis 19.23 12.60 149 154508 43963 79545768
Chimerism 19.15 12.60 10 154647 286 79589445
Carpal tunnel syndrome 19.06 12.60 7 154650 19521 79570210
Eye pruritus 19.04 12.60 8 154649 20562 79569169
Myopathy 19.03 12.60 8 154649 20555 79569176
Infection 18.99 12.60 342 154315 241370 79348361
Scintillating scotoma 18.99 12.60 9 154648 208 79589523
Hypercreatininaemia 18.98 12.60 16 154641 1037 79588694
Electrocardiogram ST segment depression 18.96 12.60 34 154623 4844 79584887
Delirium 18.89 12.60 92 154565 84535 79505196
Visceral venous thrombosis 18.86 12.60 5 154652 17 79589714
Vascular pain 18.79 12.60 15 154642 900 79588831
Haemorrhage intracranial 18.76 12.60 14 154643 26179 79563552
Periportal sinus dilatation 18.75 12.60 8 154649 143 79589588
Bronchiectasis 18.74 12.60 10 154647 22376 79567355
COVID-19 pneumonia 18.70 12.60 17 154640 28832 79560899
Gastrointestinal stoma output increased 18.67 12.60 11 154646 400 79589331
Gastrointestinal obstruction 18.66 12.60 20 154637 1752 79587979
Xeroderma 18.66 12.60 10 154647 302 79589429
Glycosylated haemoglobin increased 18.63 12.60 7 154650 19253 79570478
Product substitution issue 18.56 12.60 8 154649 20248 79569483
Toxic cardiomyopathy 18.55 12.60 11 154646 405 79589326
Altered state of consciousness 18.54 12.60 147 154510 43675 79546056
Miosis 18.48 12.60 4 154653 15785 79573946
Mixed adenoneuroendocrine carcinoma 18.43 12.60 5 154652 19 79589712
Chemotherapy cardiotoxicity attenuation 18.43 12.60 5 154652 19 79589712
Left ventricular dilatation 18.36 12.60 16 154641 1085 79588646
Catabolic state 18.30 12.60 7 154650 93 79589638
Epstein-Barr virus infection 18.26 12.60 3 154654 14413 79575318
Intrahepatic portal hepatic venous fistula 18.22 12.60 4 154653 4 79589727
Neonatal asphyxia 18.22 12.60 4 154653 4 79589727
Bile duct stenosis 18.21 12.60 21 154636 1995 79587736
Colonic fistula 18.21 12.60 13 154644 659 79589072
Blood triglycerides increased 18.20 12.60 9 154648 21031 79568700
Post procedural diarrhoea 18.17 12.60 13 154644 661 79589070
Enterocolitis infectious 18.13 12.60 25 154632 2844 79586887
Dyspnoea 18.12 12.60 1424 153233 855601 78734130
Inferior vena cava stenosis 18.08 12.60 6 154651 51 79589680
Toxic epidermal necrolysis 18.06 12.60 37 154620 44544 79545187
Tendonitis 18.04 12.60 12 154645 23818 79565913
Thrombocytopenia neonatal 18.03 12.60 5 154652 21 79589710
Mood swings 17.98 12.60 8 154649 19872 79569859
Tooth infection 17.96 12.60 7 154650 18825 79570906
Angina pectoris 17.93 12.60 166 154491 51566 79538165
Bronchiolitis obliterans syndrome 17.88 12.60 10 154647 329 79589402
Basal cell carcinoma 17.86 12.60 28 154629 37347 79552384
Incorrect route of product administration 17.83 12.60 25 154632 34904 79554827
Recurrent cancer 17.82 12.60 24 154633 2669 79587062
Anorectal discomfort 17.81 12.60 28 154629 3583 79586148
Skin exfoliation 17.71 12.60 174 154483 54926 79534805
Intestinal strangulation 17.68 12.60 6 154651 55 79589676
Papilloedema 17.61 12.60 38 154619 6195 79583536
Catheter site bruise 17.57 12.60 11 154646 447 79589284
Colon cancer 17.53 12.60 65 154592 14458 79575273
Perihepatic abscess 17.49 12.60 8 154649 170 79589561
Hepatitis B surface antigen positive 17.45 12.60 8 154649 171 79589560
Oxygen saturation decreased 17.40 12.60 163 154494 128884 79460847
Dry eye 17.33 12.60 28 154629 36903 79552828
Endometrial dysplasia 17.33 12.60 5 154652 25 79589706
Limbic encephalitis 17.24 12.60 14 154643 861 79588870
Metastases to eye 17.22 12.60 9 154648 258 79589473
Oesophageal carcinoma recurrent 17.21 12.60 6 154651 60 79589671
Gallbladder disorder 17.15 12.60 8 154649 19332 79570399
Vocal cord paralysis 17.04 12.60 23 154634 2564 79587167
Wernicke's encephalopathy 17.01 12.60 5 154652 27 79589704
T-cell type acute leukaemia 16.95 12.60 8 154649 183 79589548
Onychoclasis 16.92 12.60 35 154622 5543 79584188
Mucosal disorder 16.91 12.60 27 154630 3501 79586230
Skin hyperpigmentation 16.75 12.60 41 154616 7262 79582469
Ankle fracture 16.70 12.60 6 154651 16963 79572768
Soft tissue necrosis 16.69 12.60 14 154643 901 79588830
Viral hepatitis carrier 16.57 12.60 5 154652 30 79589701
Haemorrhagic infarction 16.57 12.60 13 154644 761 79588970
Oral dysaesthesia 16.56 12.60 8 154649 193 79589538
Colorectal cancer recurrent 16.54 12.60 6 154651 68 79589663
Arteritis 16.53 12.60 14 154643 913 79588818
Vaginal fistula 16.46 12.60 9 154648 283 79589448
Cardio-respiratory arrest 16.43 12.60 133 154524 108377 79481354
Immunodeficiency 16.43 12.60 11 154646 21757 79567974
Bone density decreased 16.42 12.60 3 154654 13344 79576387
Hypocapnia 16.42 12.60 12 154645 631 79589100
Necrosis 16.41 12.60 48 154609 9445 79580286
Blood pressure diastolic increased 16.39 12.60 4 154653 14538 79575193
Duodenal stenosis 16.37 12.60 13 154644 774 79588957
Tooth disorder 16.37 12.60 16 154641 26217 79563514
Head discomfort 16.33 12.60 4 154653 14498 79575233
Gait apraxia 16.29 12.60 5 154652 32 79589699
Tonic clonic movements 16.26 12.60 21 154636 2243 79587488
Frequent bowel movements 16.25 12.60 20 154637 29519 79560212
Hydrothorax 16.23 12.60 17 154640 1451 79588280
Hyperlipidaemia 16.19 12.60 16 154641 26077 79563654
Eastern Cooperative Oncology Group performance status worsened 16.17 12.60 20 154637 2045 79587686
Mydriasis 16.11 12.60 7 154650 17636 79572095
Mucosal ulceration 16.07 12.60 19 154638 1854 79587877
Subdiaphragmatic abscess 16.02 12.60 7 154650 133 79589598
Lactic acidosis 15.99 12.60 76 154581 70283 79519448
Dyspnoea exertional 15.97 12.60 101 154556 86972 79502759
Respiratory depression 15.95 12.60 18 154639 27612 79562119
Chronic sinusitis 15.87 12.60 3 154654 13023 79576708
Jaundice cholestatic 15.77 12.60 53 154604 11231 79578500
Herpes simplex meningomyelitis 15.74 12.60 3 154654 0 79589731
Cholecystocholangitis 15.74 12.60 3 154654 0 79589731
Cholelithiasis 15.73 12.60 51 154606 52613 79537118
Soft tissue disorder 15.62 12.60 26 154631 3489 79586242
Cardiomyopathy acute 15.61 12.60 9 154648 314 79589417
Vitamin B1 deficiency 15.54 12.60 12 154645 686 79589045
Colitis ischaemic 15.51 12.60 65 154592 15294 79574437
Renal tubular disorder 15.50 12.60 37 154620 6449 79583282
Metapneumovirus bronchiolitis 15.47 12.60 4 154653 12 79589719
Klebsiella infection 15.47 12.60 66 154591 15654 79574077
Respiratory alkalosis 15.43 12.60 29 154628 4282 79585449
Prostatic calcification 15.40 12.60 6 154651 84 79589647
Burning sensation 15.36 12.60 60 154597 58572 79531159
Middle insomnia 15.28 12.60 6 154651 16063 79573668
Female genital tract fistula 15.28 12.60 35 154622 5940 79583791
Lupus-like syndrome 15.26 12.60 4 154653 13853 79575878
Sarcoidosis 15.24 12.60 43 154614 8292 79581439
Cardiac ventricular thrombosis 15.24 12.60 18 154639 1755 79587976
Cyst 15.23 12.60 4 154653 13836 79575895
Marchiafava-Bignami disease 15.23 12.60 4 154653 13 79589718
Febrile infection 15.21 12.60 25 154632 3321 79586410
Glomerular filtration rate decreased 15.17 12.60 13 154644 22689 79567042
Joint effusion 15.15 12.60 8 154649 18006 79571725
Osteonecrosis of jaw 15.13 12.60 139 154518 43087 79546644
Blepharitis 15.10 12.60 24 154633 3100 79586631
Ileus paralytic 15.08 12.60 47 154610 9573 79580158
Aortic intramural haematoma 15.08 12.60 7 154650 154 79589577
Upper limb fracture 15.08 12.60 8 154649 17959 79571772
Hypersplenism 15.07 12.60 11 154646 577 79589154
Hip arthroplasty 15.07 12.60 29 154628 35727 79554004
Muscle rigidity 15.07 12.60 10 154647 19872 79569859
Malignant pleural effusion 15.02 12.60 25 154632 3355 79586376
Pneumatosis 14.99 12.60 13 154644 876 79588855
Arterial thrombosis 14.98 12.60 22 154635 2652 79587079
Drug eruption 14.97 12.60 40 154617 43895 79545836
Monocytopenia 14.96 12.60 7 154650 157 79589574
Granulocyte count decreased 14.95 12.60 18 154639 1790 79587941
Splenic abscess 14.94 12.60 11 154646 585 79589146
Diabetes mellitus inadequate control 14.91 12.60 15 154642 24249 79565482
Vertigo 14.90 12.60 76 154581 69006 79520725
Aortic dissection 14.84 12.60 28 154629 4147 79585584
Anal injury 14.80 12.60 7 154650 161 79589570
Infusion related reaction 14.73 12.60 337 154320 229900 79359831
Nasal crusting 14.73 12.60 11 154646 598 79589133
Dystonia 14.61 12.60 12 154645 21387 79568344
ECG signs of myocardial ischaemia 14.57 12.60 9 154648 357 79589374
Dandy-Walker syndrome 14.53 12.60 5 154652 48 79589683
Skin laceration 14.51 12.60 21 154636 28941 79560790
Eye swelling 14.47 12.60 18 154639 26450 79563281
Retroperitoneal lymphadenopathy 14.47 12.60 14 154643 1086 79588645
Periodontal disease 14.46 12.60 18 154639 1852 79587879
Pancreatic fistula 14.45 12.60 6 154651 100 79589631
Ear pain 14.43 12.60 26 154631 32843 79556888
Infectious pleural effusion 14.43 12.60 26 154631 3718 79586013
Stomal hernia 14.41 12.60 9 154648 364 79589367
Duodenal varices 14.39 12.60 4 154653 17 79589714
Nodule 14.38 12.60 14 154643 22980 79566751
Tendon rupture 14.34 12.60 3 154654 12123 79577608
Stomatitis haemorrhagic 14.34 12.60 6 154651 102 79589629
Necrotising oesophagitis 14.33 12.60 14 154643 1099 79588632
Dementia 14.31 12.60 16 154641 24643 79565088
Neurosarcoidosis 14.30 12.60 9 154648 369 79589362
Pulmonary congestion 14.23 12.60 19 154638 27081 79562650
Procedural vomiting 14.22 12.60 12 154645 779 79588952
Perioral dermatitis 14.22 12.60 9 154648 373 79589358
Temperature difference of extremities 14.21 12.60 4 154653 18 79589713
Scab 14.20 12.60 49 154608 10523 79579208
Off label use 14.16 12.60 1986 152671 905229 78684502
Hepatic cancer recurrent 14.14 12.60 8 154649 269 79589462
Mania 14.09 12.60 9 154648 18251 79571480
Pancreatic carcinoma recurrent 14.08 12.60 7 154650 180 79589551
Perineal abscess 14.05 12.60 11 154646 642 79589089
Acute cutaneous lupus erythematosus 14.00 12.60 9 154648 383 79589348
Sudden death 13.99 12.60 83 154574 22428 79567303
Product use in unapproved indication 13.97 12.60 374 154283 249985 79339746
Needle issue 13.96 12.60 4 154653 13064 79576667
Thrombophlebitis 13.93 12.60 35 154622 6300 79583431
Blood potassium increased 13.92 12.60 22 154635 29253 79560478
Palmar erythema 13.89 12.60 18 154639 1929 79587802
Metastases to bladder 13.88 12.60 8 154649 279 79589452
Osteoradionecrosis 13.88 12.60 6 154651 111 79589620
Hypertensive encephalopathy 13.87 12.60 13 154644 969 79588762
Neuropathic muscular atrophy 13.84 12.60 5 154652 56 79589675
Tumour invasion 13.84 12.60 9 154648 391 79589340
Metastases to bone marrow 13.82 12.60 12 154645 810 79588921
Lymph node abscess 13.76 12.60 5 154652 57 79589674
Enterocolitis haemorrhagic 13.69 12.60 19 154638 2175 79587556
Lhermitte's sign 13.67 12.60 3 154654 3 79589728
Carbohydrate antigen 15-3 increased 13.66 12.60 14 154643 1165 79588566
Obstruction gastric 13.63 12.60 17 154640 1753 79587978
Body temperature decreased 13.61 12.60 26 154631 32119 79557612
Portal vein dilatation 13.60 12.60 5 154652 59 79589672
Capillary leak syndrome 13.55 12.60 26 154631 3899 79585832
Catheter site thrombosis 13.53 12.60 8 154649 293 79589438
Diverticulum 13.46 12.60 6 154651 14890 79574841
Death 13.43 12.60 932 153725 565582 79024149
Traumatic fracture 13.41 12.60 13 154644 1011 79588720
Fingerprint loss 13.38 12.60 5 154652 62 79589669
Pulmonary hypertension 13.38 12.60 48 154609 48032 79541699
Cardiac murmur 13.35 12.60 7 154650 15817 79573914
Proctectomy 13.32 12.60 7 154650 203 79589528
Respiratory tract infection 13.29 12.60 49 154608 48640 79541091
Peritoneal haematoma 13.29 12.60 7 154650 204 79589527
Blood pressure decreased 13.25 12.60 126 154531 99340 79490391
Red blood cell nucleated morphology present 13.25 12.60 4 154653 24 79589707
Pleural fistula 13.25 12.60 4 154653 24 79589707
Tetany 13.24 12.60 21 154636 2707 79587024
Pseudomembranous colitis 13.22 12.60 31 154626 5343 79584388
Oesophageal squamous cell carcinoma metastatic 13.21 12.60 3 154654 4 79589727
Transposition of the great vessels 13.17 12.60 5 154652 65 79589666
Tissue injury 13.17 12.60 5 154652 65 79589666
Pleural effusion 13.15 12.60 372 154285 144890 79444841
Throat tightness 13.15 12.60 96 154561 27811 79561920
Intercepted product administration error 13.13 12.60 9 154648 427 79589304
Rectal cancer recurrent 13.11 12.60 4 154653 25 79589706
Depressed mood 13.10 12.60 49 154608 48431 79541300
Cutaneous lupus erythematosus 13.06 12.60 22 154635 2981 79586750
Dysstasia 13.05 12.60 21 154636 27725 79562006
Blood culture positive 13.05 12.60 41 154616 8388 79581343
Hepatic vein stenosis 13.03 12.60 5 154652 67 79589664
Atrioventricular block first degree 13.02 12.60 4 154653 12487 79577244
Bronchial fistula 13.01 12.60 7 154650 213 79589518
Gastric varices haemorrhage 12.98 12.60 9 154648 435 79589296
Thrombophlebitis migrans 12.93 12.60 9 154648 438 79589293
Acquired tracheo-oesophageal fistula 12.89 12.60 6 154651 133 79589598
Trismus 12.86 12.60 31 154626 5436 79584295
Renal hydrocele 12.85 12.60 4 154653 27 79589704
Blood creatine increased 12.85 12.60 44 154613 9411 79580320
Stress ulcer 12.85 12.60 6 154651 134 79589597
Blood bilirubin increased 12.84 12.60 190 154467 66042 79523689
Bladder tamponade 12.79 12.60 10 154647 582 79589149
Fungal infection 12.77 12.60 40 154617 41708 79548023
Cerebral vasoconstriction 12.76 12.60 15 154642 1455 79588276
Rectal adenocarcinoma 12.73 12.60 15 154642 1458 79588273
Catheter site extravasation 12.71 12.60 9 154648 450 79589281
Iatrogenic infection 12.70 12.60 5 154652 72 79589659
Cutaneous tuberculosis 12.63 12.60 7 154650 226 79589505
Suture rupture 12.63 12.60 10 154647 593 79589138
Product intolerance 12.61 12.60 4 154653 29 79589702
Ischaemic enteritis 12.60 12.60 6 154651 140 79589591
Disease recurrence 12.60 12.60 136 154521 43973 79545758

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01BC02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
ATC L01BC52 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
FDA EPC N0000175595 Nucleoside Metabolic Inhibitor
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:132992 radiosensitizing agents
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Actinic keratosis indication 201101007 DOID:8866
Metastasis from malignant tumor of colon indication 314998002
Malignant tumor of stomach indication 363349007 DOID:10534
Malignant tumor of colon indication 363406005 DOID:219
Small intestine cancer indication 363509000 DOID:10154
Superficial basal cell carcinoma indication 403914000
Adenocarcinoma of pancreas indication 700423003 DOID:4074
Metastatic Breast Carcinoma indication
Carcinoid syndrome off-label use 35868009
Actinic cheilitis off-label use 46795000
Radiation dermatitis off-label use 49084001
Neoplasm of glans penis off-label use 126898002
Carcinoma of breast off-label use 254838004 DOID:3459
Malignant tumor of head and/or neck off-label use 255056009
Malignant tumor of cervix off-label use 363354003 DOID:4362
Malignant tumor of esophagus off-label use 363402007
Malignant tumor of anus off-label use 363490009 DOID:14110
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Leukoplakia of oral mucosa off-label use 414603003
Pancreatic Neuroendocrine Tumor off-label use 717919005
Biliary Tract Malignancy off-label use
Metastatic Malignant Tumor of Anus off-label use
Nutritional disorder contraindication 2492009 DOID:374
Acute vomiting contraindication 23971007
Stomatitis contraindication 61170000 DOID:9637
Diarrhea contraindication 62315008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Dihydrouracil dehydrogenase (NADP^+^) deficiency contraindication 77365006 DOID:14218
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Superficial ulcer of skin contraindication 93448009
Secondary malignant neoplasm of bone marrow contraindication 94217008
Bleeding contraindication 131148009
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Pharyngitis contraindication 405737000 DOID:2275
Breastfeeding (mother) contraindication 413712001
Palmar-Plantar Erythrodysesthesia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.02 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme INHIBITOR WOMBAT-PK CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
ATP-binding cassette sub-family C member 11 Transporter WOMBAT-PK
Aromatase Enzyme IC50 6.20 CHEMBL
Thymidylate synthase Enzyme IC50 7.70 CHEMBL
Uracil phosphoribosyltransferase Enzyme Ki 4.89 CHEMBL

External reference:

IDSource
4017806 VUID
N0000146166 NUI
D00584 KEGG_DRUG
202632 RXNORM
C0016360 UMLSCUI
CHEBI:46345 CHEBI
URF PDB_CHEM_ID
CHEMBL185 ChEMBL_ID
D005472 MESH_DESCRIPTOR_UI
DB00544 DRUGBANK_ID
4789 IUPHAR_LIGAND_ID
1421 INN_ID
U3P01618RT UNII
3385 PUBCHEM_CID
3127006 SNOMEDCT_US
387172005 SNOMEDCT_US
4017806 VANDF
4694 MMSL
4745 MMSL
6969 MMSL
d00235 MMSL
002646 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3202 SOLUTION 0.50 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3202 SOLUTION 0.50 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3203 SOLUTION 1.25 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3203 SOLUTION 1.25 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3204 CREAM 2 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3204 CREAM 2 g TOPICAL NDA 2 sections
Carac HUMAN PRESCRIPTION DRUG LABEL 1 0187-5200 CREAM 5 mg TOPICAL NDA 24 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4791 CREAM 5 mg TOPICAL NDA authorized generic 19 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4791 CREAM 5 mg TOPICAL NDA authorized generic 19 sections
Fluorouracil Cream HUMAN PRESCRIPTION DRUG LABEL 1 0378-8078 CREAM 5 mg TOPICAL NDA authorized generic 22 sections
Fluoroplex HUMAN PRESCRIPTION DRUG LABEL 1 16110-812 CREAM 10 mg TOPICAL NDA 23 sections
Fluoroplex HUMAN PRESCRIPTION DRUG LABEL 1 16110-812 CREAM 10 mg TOPICAL NDA 23 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16714-178 CREAM 50 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-276 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 24 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-276 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 24 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-542 CREAM 50 mg TOPICAL ANDA 19 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-542 CREAM 50 mg TOPICAL ANDA 19 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-542 CREAM 50 mg TOPICAL ANDA 19 sections
FLUOROURACIL HUMAN PRESCRIPTION DRUG LABEL 1 21695-829 CREAM 50 mg TOPICAL ANDA 18 sections
fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 25021-215 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
TOLAK HUMAN PRESCRIPTION DRUG LABEL 1 28105-421 CREAM 0.04 g TOPICAL NDA 26 sections
TOLAK HUMAN PRESCRIPTION DRUG LABEL 1 28105-421 CREAM 0.04 g TOPICAL NDA 26 sections
Fluorouracil Human Prescription Drug Label 1 46708-751 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 24 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 50090-4264 CREAM 50 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4062 SOLUTION 20 mg TOPICAL ANDA 21 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4062 SOLUTION 20 mg TOPICAL ANDA 21 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4063 SOLUTION 50 mg TOPICAL ANDA 21 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4063 SOLUTION 50 mg TOPICAL ANDA 21 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4118 CREAM 50 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4118 CREAM 50 mg TOPICAL ANDA 20 sections