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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tocainide 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
Class I antiarrhythmics, procainamide and lidocaine derivatives
2686
41708-72-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tocainide hydrochloride
tocainide
(RS)-Tocainide
(+/-)-Tocainide
DL-Tocainide
tocainide HCl
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of SODIUM CHANNELS.
Molecular weight: 192.26
Formula: C11H16N2O
CLOGP: 0.26
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 55.12
ALOGS: -2.08
ROTB: 2
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
1.20
g
O
1.20
g
P
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
89 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
EoM (Fraction excreted unchanged in urine)
38 %
Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)
2.20 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
12 hours
Lombardo F, Berellini G, Obach RS
S (Water solubility)
10 mg/mL
Benet LZ, Broccatelli F, Oprea TI
Vd (Volume of distribution)
1.80 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.87 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 8 of 8 entries
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Approvals:
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Date
Agency
Company
Orphan
Nov. 9, 1984
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C01BB03
CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ib
CHEBI has role
CHEBI:36333
local anesthetics
CHEBI has role
CHEBI:38070
antiarrhythmic agent
CHEBI has role
CHEBI:38633
sodium channel blockers
MeSH PA
D000889
Anti-Arrhythmia Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D049990
Membrane Transport Modulators
MeSH PA
D026941
Sodium Channel Blockers
MeSH PA
D061567
Voltage-Gated Sodium Channel Blockers
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Ventricular arrhythmia
indication
44103008
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.41
acidic
pKa2
7.53
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Sodium channel alpha subunit
Ion channel
P35498
P35499
Q01118
Q14524
Q15858
Q99250
Q9NY46
Q9UI33
Q9UQD0
Q9Y5Y9
SCN1A_HUMAN
SCN4A_HUMAN
SCN7A_HUMAN
SCN5A_HUMAN
SCN9A_HUMAN
SCN2A_HUMAN
SCN3A_HUMAN
SCNBA_HUMAN
SCN8A_HUMAN
SCNAA_HUMAN
BLOCKER
CHEMBL
CHEMBL
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External reference:
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ID
Source
000625
NDDF
004482
NDDF
10555000
SNOMEDCT_US
142145
RXNORM
2195004
SNOMEDCT_US
27DXO59SAN
UNII
372479006
SNOMEDCT_US
38945
PUBCHEM_CID
4017953
VUID
4017953
VANDF
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Pharmaceutical products:
None
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tocainide