tioconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| systemic antifungal agents, miconazole derivatives | 2675 | 65899-73-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | V |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 18, 1983 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypercholesterolaemia | 57.33 | 53.31 | 17 | 638 | 21317 | 63467050 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AC07 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| ATC | G01AF08 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives |
| FDA CS | M0002083 | Azoles |
| FDA EPC | N0000175487 | Azole Antifungal |
| MeSH PA | D058888 | 14-alpha Demethylase Inhibitors |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
| MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
| MeSH PA | D065088 | Steroid Synthesis Inhibitors |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:77884 | sterol 14alpha-demethylase inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Candidal vulvovaginitis | indication | 72605008 | DOID:2272 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Steroid 17-alpha-hydroxylase/17,20 lyase | Enzyme | Ki | 6.30 | CHEMBL | |||||
| Lanosterol 14-alpha demethylase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020459 | VUID |
| N0000148215 | NUI |
| D00890 | KEGG_DRUG |
| 4020459 | VANDF |
| C0076705 | UMLSCUI |
| CHEBI:9604 | CHEBI |
| FJQ | PDB_CHEM_ID |
| CHEMBL1200438 | ChEMBL_ID |
| DB01007 | DRUGBANK_ID |
| C020527 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5482 | PUBCHEM_CID |
| 4572 | INN_ID |
| S57Y5X1117 | UNII |
| 38298 | RXNORM |
| 5586 | MMSL |
| 002926 | NDDF |
| 332967005 | SNOMEDCT_US |
| 395909003 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| good sense tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 0113-0426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| basic care tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 0113-7426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| basic care tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 0113-7426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 0363-0426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 0363-0426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| vagistat | HUMAN OTC DRUG LABEL | 1 | 11509-0426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Up and up tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 11673-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| tioconazole 11 dose treatment | HUMAN OTC DRUG LABEL | 1 | 11822-0426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| signature care tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 21130-060 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 30142-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Topcare Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 36800-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 37808-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Equaline Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 41163-032 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Equaline Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 41163-032 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 41250-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| CareOne Tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 41520-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| Equate tioconazole 1 day | HUMAN OTC DRUG LABEL | 1 | 49035-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| SUNMARK TIOCONAZOLE 1 | HUMAN OTC DRUG LABEL | 1 | 49348-508 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| dg health tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 55910-731 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| tioconazole 1 | HUMAN OTC DRUG LABEL | 1 | 59779-718 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| TIOCONAZOLEOintment 6.5% | HUMAN OTC DRUG LABEL | 1 | 63094-0426 | OINTMENT | 65 mg | VAGINAL | ANDA | 24 sections |
| Tioconazole1 Day | HUMAN OTC DRUG LABEL | 1 | 63736-410 | OINTMENT | 300 mg | TOPICAL | ANDA | 16 sections |
| MONISTAT TIOCONAZOLE 1 | HUMAN OTC DRUG LABEL | 1 | 63736-413 | OINTMENT | 6.50 g | TOPICAL | ANDA | 15 sections |
| Leader Ticonazole | HUMAN OTC DRUG LABEL | 1 | 70000-0357 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |
| basic care tioconazole | HUMAN OTC DRUG LABEL | 1 | 72288-426 | OINTMENT | 6.50 g | VAGINAL | ANDA | 16 sections |