All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

tioconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	2675	65899-73-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: UK-20,349 UK-20349 tioconazole	Molecular weight: 387.70 Formula: C16H13Cl3N2OS CLOGP: 4.79 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 27.05 ALOGS: -4.37 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.30	g	V

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	4.492		Moderate	0.78
caco2-efflux	Caco-2 efflux ratio (BA/AB)	1.030		Moderate	0.78
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	44.259	10^-6 cm/s	Moderate	0.78
dh-clint	Dog hepatocyte intrinsic clearance	73.451	uL/min/10^6 cells	Moderate	0.78
dppb	Dog plasma protein binding (% unbound)	0.370	%	Moderate	0.78
fcs-ppb	Fetal calf serum protein binding (% unbound)	1.170	%	Moderate	0.78
herg	hERG pIC50	5.812	pIC50	Moderate	0.78
hh-clint	Human hepatocyte intrinsic clearance	88.920	uL/min/10^6 cells	Moderate	0.78
hlm-clint	Human liver microsomal intrinsic clearance	234.423	uL/min/mg protein	Moderate	0.78
hppb	Human plasma protein binding (% unbound)	0.470	%	Moderate	0.78
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK	42
kinase-selectivity-class	AKT3,AXL,BRAF,EIF2AK3,GRK2,PDK4,PIK3CB	7
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.607		Moderate	0.78
mh-clint	Mouse hepatocyte intrinsic clearance	138.676		Moderate	0.78
mppb	Mouse plasma protein binding (% unbound)	0.440		Moderate	0.78
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	1.941		Moderate	0.78
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	1.850	%	Moderate	0.78
rh-clint	Rat hepatocyte intrinsic clearance	190.546	uL/min/10^6 cells	Moderate	0.78
rh-fuinc	Rat hepatocyte fraction unbound in incubation	6.900	%	Moderate	0.78
rppb	Rat plasma protein binding (% unbound)	0.390	%	Moderate	0.78
solubility-dd	Solubility at pH 7.4 in DMSO	95.940	uM	Moderate	0.78

Approvals:

Date	Agency	Company	Orphan
Feb. 18, 1983	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D01AC07	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives
ATC	G01AF08	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D058888	14-alpha Demethylase Inhibitors
MeSH PA	D065088	Steroid Synthesis Inhibitors
MeSH PA	D065606	Metabolic Side Effects of Drugs and Substances
MeSH PA	D065607	Cytochrome P-450 Enzyme Inhibitors
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:77884	EC 1.14.13.70 (sterol 14α-demethylase) inhibitor

Related Drugs by ATC class:

D01AC Imidazole and triazole derivatives 20 drugs

bifonazolechlormidazoleclotrimazoleeberconazoleeconazoleefinaconazolefenticonazolefluconazoleflutrimazoleisoconazoleketoconazolelanoconazole show all 20 →

G01AF Imidazole derivatives 16 drugs

azanidazolebutoconazoleclotrimazoleeconazolefenticonazoleflutrimazoleisoconazoleketoconazolemetronidazolemiconazoleomoconazoleornidazole show all 16 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Candidal vulvovaginitis	indication	72605008	DOID:2272

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.49	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Steroid 17-alpha-hydroxylase/17,20 lyase	Enzyme	P05093	CP17A_HUMAN		Ki	6.30		CHEMBL
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase	Enzyme	Q9UNU6	CP8B1_HUMAN	INHIBITOR	Kd	6.68		IUPHAR
Cysteine protease ATG4A	Enzyme	Q8WYN0	ATG4A_HUMAN		IC50	5.89		CHEMBL
Cysteine protease ATG4B	Enzyme	Q9Y4P1	ATG4B_HUMAN		IC50	5.75		CHEMBL
Lanosterol 14-alpha demethylase	Enzyme		CP51_CANAL	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4020459	VUID
N0000148215	NUI
D00890	KEGG_DRUG
4020459	VANDF
C0076705	UMLSCUI
CHEBI:9604	CHEBI
FJQ	PDB_CHEM_ID
CHEMBL1200438	ChEMBL_ID
DB01007	DRUGBANK_ID
C020527	MESH_SUPPLEMENTAL_RECORD_UI
5482	PUBCHEM_CID
13859	IUPHAR_LIGAND_ID
4572	INN_ID
S57Y5X1117	UNII
38298	RXNORM
5586	MMSL
002926	NDDF
332967005	SNOMEDCT_US
395909003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense tioconazole 1	HUMAN OTC DRUG LABEL	1	0113-0426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
Tioconazole 1	HUMAN OTC DRUG LABEL	1	0363-0426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
VAGISTAT	HUMAN OTC DRUG LABEL	1	11509-0426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
Up and up tioconazole 1	HUMAN OTC DRUG LABEL	1	11673-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
signature care tioconazole 1	HUMAN OTC DRUG LABEL	1	21130-060	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
TIOCONAZOLE 1	HUMAN OTC DRUG LABEL	1	21130-781	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
Topcare Tioconazole 1	HUMAN OTC DRUG LABEL	1	36800-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
Tioconazole 1	HUMAN OTC DRUG LABEL	1	37808-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
Equaline Tioconazole 1	HUMAN OTC DRUG LABEL	1	41163-032	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
tioconazole 1	HUMAN OTC DRUG LABEL	1	41250-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
CareOne Tioconazole 1	HUMAN OTC DRUG LABEL	1	41520-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
Equate tioconazole 1 day	HUMAN OTC DRUG LABEL	1	49035-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
dg health tioconazole 1	HUMAN OTC DRUG LABEL	1	55910-731	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
tioconazole 1	HUMAN OTC DRUG LABEL	1	59779-718	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
TIOCONAZOLEOintment 6.5%	HUMAN OTC DRUG LABEL	1	63094-0426	OINTMENT	65 mg	VAGINAL	ANDA	12 sections
Tioconazole1 Day	HUMAN OTC DRUG LABEL	1	63736-410	OINTMENT	300 mg	TOPICAL	ANDA	16 sections
MONISTAT TIOCONAZOLE 1	HUMAN OTC DRUG LABEL	1	63736-413	OINTMENT	6.50 g	TOPICAL	ANDA	15 sections
Leader Tioconazole 1	HUMAN OTC DRUG LABEL	1	70000-0357	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
foster and thrive tioconazole	HUMAN OTC DRUG LABEL	1	70677-1224	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections
basic care tioconazole	HUMAN OTC DRUG LABEL	1	72288-426	OINTMENT	6.50 g	VAGINAL	ANDA	16 sections