Stem definition | Drug id | CAS RN |
---|---|---|
calcium metabolism regulator, pharmaceutical aid | 2666 | 89987-06-4 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 60 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 17.52 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 6 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 7.70 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 7, 1997 | FDA |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | M05BA05 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates |
FDA CS | M0006519 | Diphosphonates |
FDA EPC | N0000175579 | Bisphosphonate |
MeSH PA | D050071 | Bone Density Conservation Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Osteitis deformans | indication | 2089002 | DOID:5408 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Hypocalcemia | contraindication | 5291005 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hyperphosphatemia | contraindication | 20165001 | DOID:0050459 |
Vitamin D deficiency | contraindication | 34713006 | |
Dysphagia | contraindication | 40739000 | |
Periodontitis | contraindication | 41565005 | DOID:824 |
Acute nephropathy | contraindication | 58574008 | |
Stricture of esophagus | contraindication | 63305008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Fracture of femur | contraindication | 71620000 | |
Duodenitis | contraindication | 72007001 | DOID:8643 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Bed-ridden | contraindication | 160685001 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Anemia | contraindication | 271737000 | DOID:2355 |
Primary malignant neoplasm | contraindication | 372087000 | |
Aseptic necrosis of bone of jaw | contraindication | 441809006 | |
Esophageal Obstruction | contraindication | ||
Invasive Dental Procedure | contraindication |
Species | Use | Relation |
---|---|---|
Horses | Navicular syndrome | Indication |
Product | Applicant | Ingredients |
---|---|---|
Tildren | Bimeda Animal Health Limited | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.19 | acidic |
pKa2 | 6.26 | acidic |
pKa3 | 7.24 | acidic |
pKa4 | 11.31 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 1 | Enzyme | WOMBAT-PK | |||||||
V-type proton ATPase 116 kDa subunit a isoform 3 | Enzyme | WOMBAT-PK | |||||||
72 kDa type IV collagenase | Enzyme | IC50 | 5.14 | CHEMBL | |||||
Matrix metalloproteinase-14 | Enzyme | IC50 | 4.52 | CHEMBL | |||||
Interstitial collagenase | Enzyme | IC50 | 4.30 | CHEMBL | |||||
Neutrophil collagenase | Enzyme | IC50 | 4.49 | CHEMBL |
ID | Source |
---|---|
D02285 | KEGG_DRUG |
149845-07-8 | SECONDARY_CAS_RN |
4021043 | VANDF |
4024072 | VANDF |
C0043611 | UMLSCUI |
CHEBI:9598 | CHEBI |
CHEMBL1350 | ChEMBL_ID |
DB01133 | DRUGBANK_ID |
CHEMBL1200448 | ChEMBL_ID |
C058651 | MESH_SUPPLEMENTAL_RECORD_UI |
60937 | PUBCHEM_CID |
7604 | IUPHAR_LIGAND_ID |
6325 | INN_ID |
6PNS59HP4Y | UNII |
11476 | RXNORM |
5583 | MMSL |
d04124 | MMSL |
006071 | NDDF |
006072 | NDDF |
395905009 | SNOMEDCT_US |
422263009 | SNOMEDCT_US |
426050007 | SNOMEDCT_US |
96286006 | SNOMEDCT_US |
None