ticarcillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, 6-aminopenicillanic acid derivatives	2656	34787-01-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: ticarcillin ticarcillin disodium ticarcillin sodium	An antibiotic derived from penicillin similar to CARBENICILLIN in action. Molecular weight: 384.42 Formula: C15H16N2O6S2 CLOGP: 1.28 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 124.01 ALOGS: -3.73 ROTB: 5 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ticarcillin
ticarcillin disodium
ticarcillin sodium

An antibiotic derived from penicillin similar to CARBENICILLIN in action.

Molecular weight: 384.42
Formula: C15H16N2O6S2
CLOGP: 1.28
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 124.01
ALOGS: -3.73
ROTB: 5

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
15	g	P
15	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	1000 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	77 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	780.37 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	0 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.16 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.55 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Nov. 9, 1976	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Bronchiectasis	177.24	137.18	41	770	16101	63472110
Bone erosion	173.45	137.18	41	770	17676	63470535
Hypothyroidism	137.75	137.18	41	770	42591	63445620

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Bone erosion	109.46	103.82	26	625	17821	79725916

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01CA13	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum
ATC	J01CR03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Combinations of penicillins, incl. beta-lactamase inhibitors
FDA CS	M0016152	Penicillins
FDA EPC	N0000175497	Penicillin-class Antibacterial
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
CHEBI has role	CHEBI:36047	antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Septicemia due to Escherichia coli	indication	9323009
Bacterial septicemia	indication	10001005	DOID:0040085
Infection of skin AND/OR subcutaneous tissue	indication	19824006
Staphylococcal pneumonia	indication	22754005
Pneumonia due to Pseudomonas	indication	41381004
Pneumonia due to Escherichia coli	indication	51530003
Bacterial pneumonia	indication	53084003	DOID:874
Empyema of pleura	indication	58554001	DOID:3798
Klebsiella cystitis	indication	60867007
Urinary tract infectious disease	indication	68566005
Haemophilus influenzae pneumonia	indication	70036007
Infection due to Escherichia coli	indication	71057007
Bacterial infection due to Serratia	indication	71120004
Rhinoscleroma	indication	72409005	DOID:11336
Abscess of lung	indication	73452002	DOID:0060317
Salpingitis	indication	88157006	DOID:5733
Pelvic abscess	indication	111367007
Infectious disease of abdomen	indication	128070006
Infection due to Enterobacteriaceae	indication	128945009
Bacterial infection due to Klebsiella pneumoniae	indication	186435004
Proteus pneumonia	indication	195888009
Proteus septicemia	indication	300986008
Escherichia coli urinary tract infection	indication	301011002
Bacterial urinary infection	indication	312124009
Infection due to Staphylococcus aureus	indication	406602003
Aspiration pneumonia	indication	422588002	DOID:3240
Osteomyelitis due to Staphylococcus aureus	indication	428783003
Sepsis due to Staphylococcus aureus	indication	448417001
Sepsis due to Pseudomonas	indication	448813005
Sepsis due to Gram negative bacteria	indication	449082003
Bacteroides Endometritis	indication
Enterobacter Pneumonia	indication
Skin and Skin Structure Pseudomonas Aeruginosa Infection	indication
Skin and Skin Structure Providencia Infection	indication
Staphylococcus Aureus Joint Infection	indication
E. Coli Endometritis	indication
Bacteroides Peritonitis	indication
Staphylococcus Aureus Urinary Tract Infection	indication
Pseudomonas Aeruginosa Urinary Tract Infection	indication
Skin and Skin Structure Proteus Infection	indication
Complicated Urinary Tract Infections	indication
Skin and Skin Structure Morganella Morganii Infection	indication
Klebsiella Pneumoniae Peritonitis	indication
Morganella Septicemia	indication
Enterobacter Endometritis	indication
Serratia Urinary Tract Infection	indication
E. Coli Peritonitis	indication
Staphylococcus Endometritis	indication
Inflammatory Disease of Female Pelvic Organs	indication
Klebsiella Endometritis	indication
Genitourinary Tract Infections	indication
Citrobacter Urinary Tract Infection	indication
Complicated Genitourinary Tract Infection	indication
Providencia Septicemia	indication
Pyrexia of unknown origin	off-label use	7520000
Chronic purulent otitis media	off-label use	38394007	DOID:14247
Cholangitis	off-label use	82403002	DOID:9446
Infection of bone	off-label use	111253001
Escherichia coli meningitis	off-label use	192655005
Diverticulitis of gastrointestinal tract	off-label use	271366000
Infectious disorder of joint	off-label use	363162000
Abscess of brain	off-label use	441806004
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis	off-label use
Diabetic Foot Infection	off-label use
Pseudomonas Aeruginosa Meningitis	off-label use
Kidney disease	contraindication	90708001	DOID:557
Infectious mononucleosis	contraindication	271558008	DOID:8568
Pseudomembranous enterocolitis	contraindication	397683000

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Endometritis caused by beta-hemolytic streptococci	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Ticillin	Zoetis Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.79	acidic
pKa2	3.39	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Bacterial penicillin-binding protein	Enzyme		PBPA_ECOLI PBPB_ECOLI DACC_ECOLI PBP2_ECOLI FTSI_ECOLI DACA_ECOLI DACB_ECOLI	INHIBITOR				CHEMBL	CHEMBL
Penicillin-binding protein 1A	Enzyme		PBPA_CLOPE					WOMBAT-PK

External reference:

ID	Source
4019948	VUID
N0000148033	NUI
D02241	KEGG_DRUG
29457-07-6	SECONDARY_CAS_RN
4018409	VANDF
4019948	VANDF
C0040193	UMLSCUI
CHEBI:9587	CHEBI
XT8	PDB_CHEM_ID
CHEMBL1449	ChEMBL_ID
DB01607	DRUGBANK_ID
CHEMBL1200855	ChEMBL_ID
D013982	MESH_DESCRIPTOR_UI
36921	PUBCHEM_CID
10928	IUPHAR_LIGAND_ID
3406	INN_ID
F93UJX4SWT	UNII
10591	RXNORM
5581	MMSL
d00121	MMSL
002708	NDDF
004838	NDDF
111119006	SNOMEDCT_US
1148001	SNOMEDCT_US
372577006	SNOMEDCT_US

Pharmaceutical products:

None