DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tianeptine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
2650
72797-41-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tianeptine monosodium
tianeptine sodium
stablon
tianeptine
coaxil
Molecular weight: 436.95
Formula: C21H25ClN2O4S
CLOGP: 1.52
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 86.71
ALOGS: -5.03
ROTB: 8
Drug dosage:
Dose
Unit
Route
37.50
mg
O
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
99 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
2.80 mL/min/kg
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
1.40 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.30 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.05 %
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Overdose
68.21
40.42
34
960
115044
63372984
Intentional overdose
62.65
40.42
28
966
74124
63413904
Suicide attempt
54.63
40.42
24
970
60894
63427134
Drug interaction
48.82
40.42
35
959
229096
63258932
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Serotonin syndrome
101.62
54.40
28
470
19905
34936528
Stress cardiomyopathy
78.81
54.40
15
483
2044
34954389
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Serotonin syndrome
117.94
33.85
40
1373
44987
79697988
Overdose
51.66
33.85
35
1378
184171
79558804
Stress cardiomyopathy
50.20
33.85
15
1398
11151
79731824
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N06AX14
NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
CHEBI has role
CHEBI:35474
anti-anxiety agents
CHEBI has role
CHEBI:55322
mu-opioid agonists
CHEBI has role
CHEBI:65191
atypical antipsychotic agent
MeSH PA
D000928
Antidepressive Agents
MeSH PA
D000929
Antidepressive Agents, Tricyclic
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D011619
Psychotropic Drugs
Showing 1 to 8 of 8 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.76
acidic
pKa2
6.85
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Mu-type opioid receptor
GPCR
P35372
OPRM_HUMAN
Ki
6.42
PDSP
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External reference:
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ID
Source
005515
NDDF
005516
NDDF
0T493YFU8O
UNII
1172815007
SNOMEDCT_US
30123-17-2
SECONDARY_CAS_RN
38252
RXNORM
4906
INN_ID
68870
PUBCHEM_CID
703713005
SNOMEDCT_US
703714004
SNOMEDCT_US
Showing 1 to 10 of 17 entries
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Pharmaceutical products:
None
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tianeptine