tiamenidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihypertensives, clonidine derivatives 2649 31428-61-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tiamenidine hydrochloride
  • tiamenidine
  • thiamendidine
  • Molecular weight: 215.70
  • Formula: C8H10ClN3S
  • CLOGP: 1.01
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 36.42
  • ALOGS: -3.17
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR IC50 8.04 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 5.31 CHEMBL

External reference:

IDSource
D06125 KEGG_DRUG
51274-83-0 SECONDARY_CAS_RN
C0076650 UMLSCUI
CHEBI:134896 CHEBI
CHEMBL295409 ChEMBL_ID
CHEMBL2107008 ChEMBL_ID
39974 PUBCHEM_CID
3325 INN_ID
C010354 MESH_SUPPLEMENTAL_RECORD_UI
195V08O55G UNII

Pharmaceutical products:

None