Stem definition | Drug id | CAS RN |
---|---|---|
2646 | 51-48-9 |
Dose | Unit | Route |
---|---|---|
0.15 | mg | O |
0.15 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.01 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 21, 2000 | FDA | STEVENS J | |
Jan. 23, 2020 | PMDA | Aska Pharmaceutical Co., Ltd |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 1551.56 | 10.38 | 71 | 662961 | 157141 | 55471894 |
Systemic lupus erythematosus | 1236.78 | 10.38 | 300 | 662732 | 179778 | 55449257 |
Rheumatoid arthritis | 1188.77 | 10.38 | 1666 | 661366 | 380938 | 55248097 |
Glossodynia | 1143.41 | 10.38 | 207 | 662825 | 152251 | 55476784 |
Hypothyroidism | 1097.41 | 10.38 | 1764 | 661268 | 36432 | 55592603 |
Contraindicated product administered | 1060.82 | 10.38 | 433 | 662599 | 185853 | 55443182 |
Drug ineffective | 985.83 | 10.38 | 6574 | 656458 | 912415 | 54716620 |
Hand deformity | 961.36 | 10.38 | 205 | 662827 | 134287 | 55494748 |
Blood thyroid stimulating hormone increased | 930.99 | 10.38 | 705 | 662327 | 5858 | 55623177 |
Anti-cyclic citrullinated peptide antibody positive | 876.30 | 10.38 | 77 | 662955 | 98523 | 55530512 |
Synovitis | 861.36 | 10.38 | 411 | 662621 | 160894 | 55468141 |
Treatment failure | 856.47 | 10.38 | 470 | 662562 | 169922 | 55459113 |
Pericarditis | 790.82 | 10.38 | 160 | 662872 | 108763 | 55520272 |
Drug intolerance | 716.00 | 10.38 | 1264 | 661768 | 263554 | 55365481 |
Infusion related reaction | 711.39 | 10.38 | 848 | 662184 | 208083 | 55420952 |
Arthropathy | 707.68 | 10.38 | 789 | 662243 | 199486 | 55429549 |
Wound | 681.40 | 10.38 | 394 | 662638 | 138410 | 55490625 |
Maternal exposure during pregnancy | 626.60 | 10.38 | 787 | 662245 | 188766 | 55440269 |
Duodenal ulcer perforation | 581.87 | 10.38 | 63 | 662969 | 68279 | 55560756 |
Rheumatoid factor positive | 555.31 | 10.38 | 77 | 662955 | 68983 | 55560052 |
Therapeutic product effect decreased | 537.92 | 10.38 | 725 | 662307 | 168727 | 55460308 |
Discomfort | 511.01 | 10.38 | 549 | 662483 | 141212 | 55487823 |
Abdominal discomfort | 500.95 | 10.38 | 1636 | 661396 | 275638 | 55353397 |
Helicobacter infection | 489.21 | 10.38 | 129 | 662903 | 73139 | 55555896 |
Swelling | 469.78 | 10.38 | 1363 | 661669 | 238408 | 55390627 |
Hepatic enzyme increased | 449.37 | 10.38 | 833 | 662199 | 170551 | 55458484 |
Folliculitis | 440.37 | 10.38 | 62 | 662970 | 54917 | 55574118 |
Joint swelling | 430.85 | 10.38 | 1852 | 661180 | 287948 | 55341087 |
Muscle injury | 428.11 | 10.38 | 56 | 662976 | 52444 | 55576591 |
Drug hypersensitivity | 420.03 | 10.38 | 1741 | 661291 | 273464 | 55355571 |
Off label use | 411.31 | 10.38 | 4380 | 658652 | 551800 | 55077235 |
Lower respiratory tract infection | 395.65 | 10.38 | 461 | 662571 | 114333 | 55514702 |
Alopecia | 382.85 | 10.38 | 1966 | 661066 | 291492 | 55337543 |
Blood thyroid stimulating hormone abnormal | 352.46 | 10.38 | 179 | 662853 | 645 | 55628390 |
Sleep disorder due to general medical condition, insomnia type | 328.65 | 10.38 | 57 | 662975 | 43281 | 55585754 |
Hypersensitivity | 321.89 | 10.38 | 1740 | 661292 | 254668 | 55374367 |
Fall | 317.07 | 10.38 | 5941 | 657091 | 351569 | 55277466 |
Product use issue | 315.76 | 10.38 | 1127 | 661905 | 184914 | 55444121 |
Hyperthyroidism | 314.96 | 10.38 | 565 | 662467 | 12787 | 55616248 |
Blood thyroid stimulating hormone decreased | 293.15 | 10.38 | 306 | 662726 | 4027 | 55625008 |
Irritable bowel syndrome | 264.98 | 10.38 | 249 | 662783 | 68209 | 55560826 |
Exposure during pregnancy | 244.76 | 10.38 | 806 | 662226 | 135536 | 55493499 |
Thyroid function test abnormal | 235.05 | 10.38 | 244 | 662788 | 3189 | 55625846 |
Asthenia | 213.05 | 10.38 | 5416 | 657616 | 337557 | 55291478 |
Completed suicide | 209.90 | 10.38 | 837 | 662195 | 132996 | 55496039 |
Infection | 207.53 | 10.38 | 1442 | 661590 | 198764 | 55430271 |
Blood thyroid stimulating hormone normal | 206.78 | 10.38 | 71 | 662961 | 52 | 55628983 |
Impaired healing | 199.52 | 10.38 | 455 | 662577 | 86386 | 55542649 |
Pain | 197.68 | 10.38 | 6130 | 656902 | 657054 | 54971981 |
Blister | 196.57 | 10.38 | 642 | 662390 | 108245 | 55520790 |
Palpitations | 189.63 | 10.38 | 1901 | 661131 | 97771 | 55531264 |
Product substitution issue | 187.87 | 10.38 | 483 | 662549 | 14116 | 55614919 |
Dizziness | 186.65 | 10.38 | 5772 | 657260 | 370368 | 55258667 |
Thyroid disorder | 185.46 | 10.38 | 467 | 662565 | 13471 | 55615564 |
Toxicity to various agents | 183.73 | 10.38 | 1724 | 661308 | 222840 | 55406195 |
Myalgia | 180.44 | 10.38 | 2361 | 660671 | 129664 | 55499371 |
Gastrointestinal disorder | 165.43 | 10.38 | 723 | 662309 | 111979 | 55517056 |
Ill-defined disorder | 164.12 | 10.38 | 351 | 662681 | 68192 | 55560843 |
Hyponatraemia | 163.55 | 10.38 | 1882 | 661150 | 100257 | 55528778 |
Rash | 162.48 | 10.38 | 4494 | 658538 | 488553 | 55140482 |
Stomatitis | 146.88 | 10.38 | 828 | 662204 | 119982 | 55509053 |
Rheumatic fever | 146.86 | 10.38 | 78 | 662954 | 28749 | 55600286 |
Musculoskeletal stiffness | 145.66 | 10.38 | 1157 | 661875 | 154850 | 55474185 |
Muscle spasms | 143.98 | 10.38 | 2346 | 660686 | 135025 | 55494010 |
Swollen joint count increased | 141.09 | 10.38 | 54 | 662978 | 24130 | 55604905 |
Drug abuse | 139.82 | 10.38 | 374 | 662658 | 67236 | 55561799 |
Balance disorder | 138.14 | 10.38 | 1444 | 661588 | 75076 | 55553959 |
Constipation | 136.52 | 10.38 | 3227 | 659805 | 198716 | 55430319 |
Feeling abnormal | 135.35 | 10.38 | 2269 | 660763 | 131333 | 55497702 |
Atrial fibrillation | 130.29 | 10.38 | 1902 | 661130 | 106995 | 55522040 |
Febrile neutropenia | 122.61 | 10.38 | 734 | 662298 | 104811 | 55524224 |
C-reactive protein abnormal | 122.30 | 10.38 | 152 | 662880 | 36657 | 55592378 |
Product use in unapproved indication | 120.33 | 10.38 | 1069 | 661963 | 139753 | 55489282 |
Drug resistance | 114.73 | 10.38 | 49 | 662983 | 20493 | 55608542 |
Orthostatic hypotension | 111.26 | 10.38 | 721 | 662311 | 32478 | 55596557 |
Vertigo | 110.66 | 10.38 | 1055 | 661977 | 53517 | 55575518 |
Hip arthroplasty | 107.16 | 10.38 | 181 | 662851 | 38442 | 55590593 |
Product prescribing error | 105.42 | 10.38 | 546 | 662486 | 22640 | 55606395 |
Intentional product use issue | 103.88 | 10.38 | 717 | 662315 | 99016 | 55530019 |
Drug tolerance decreased | 103.08 | 10.38 | 17 | 663015 | 13394 | 55615641 |
Syncope | 101.77 | 10.38 | 1816 | 661216 | 106383 | 55522652 |
Intentional overdose | 101.74 | 10.38 | 434 | 662598 | 67683 | 55561352 |
Dysgeusia | 101.08 | 10.38 | 826 | 662206 | 40089 | 55588946 |
Vision blurred | 96.95 | 10.38 | 1443 | 661589 | 81500 | 55547535 |
Psoriatic arthropathy | 93.33 | 10.38 | 501 | 662531 | 73507 | 55555528 |
Red blood cell sedimentation rate abnormal | 91.54 | 10.38 | 53 | 662979 | 18620 | 55610415 |
Autoimmune thyroiditis | 90.32 | 10.38 | 156 | 662876 | 3422 | 55625613 |
Therapy non-responder | 88.54 | 10.38 | 396 | 662636 | 60959 | 55568076 |
Blood calcium decreased | 88.27 | 10.38 | 530 | 662502 | 23239 | 55605796 |
Nasopharyngitis | 87.97 | 10.38 | 1957 | 661075 | 219002 | 55410033 |
Cognitive disorder | 85.75 | 10.38 | 921 | 662111 | 48212 | 55580823 |
Condition aggravated | 85.53 | 10.38 | 3260 | 659772 | 341638 | 55287397 |
Product complaint | 84.82 | 10.38 | 318 | 662714 | 11442 | 55617593 |
Cytomegalovirus infection | 84.76 | 10.38 | 62 | 662970 | 19234 | 55609801 |
Tremor | 84.20 | 10.38 | 1943 | 661089 | 119146 | 55509889 |
Disturbance in attention | 83.13 | 10.38 | 662 | 662370 | 31878 | 55597157 |
Transplant rejection | 82.42 | 10.38 | 10 | 663022 | 9924 | 55619111 |
Product quality issue | 82.37 | 10.38 | 648 | 662384 | 31088 | 55597947 |
Dysphagia | 81.93 | 10.38 | 1389 | 661643 | 80558 | 55548477 |
Liver injury | 80.23 | 10.38 | 240 | 662792 | 41608 | 55587427 |
Myelosuppression | 76.78 | 10.38 | 56 | 662976 | 17399 | 55611636 |
Sedation complication | 76.34 | 10.38 | 306 | 662726 | 11366 | 55617669 |
Dehydration | 76.05 | 10.38 | 2428 | 660604 | 156397 | 55472638 |
Pyrexia | 75.85 | 10.38 | 4096 | 658936 | 414677 | 55214358 |
Therapeutic product effect incomplete | 75.47 | 10.38 | 841 | 662191 | 105190 | 55523845 |
Knee arthroplasty | 75.04 | 10.38 | 268 | 662764 | 43991 | 55585044 |
Creatinine renal clearance decreased | 74.82 | 10.38 | 355 | 662677 | 14204 | 55614831 |
Nausea | 73.52 | 10.38 | 10167 | 652865 | 754011 | 54875024 |
Therapeutic response unexpected | 72.45 | 10.38 | 394 | 662638 | 16650 | 55612385 |
Hepatic function abnormal | 71.56 | 10.38 | 191 | 662841 | 34367 | 55594668 |
Product formulation issue | 71.00 | 10.38 | 56 | 662976 | 497 | 55628538 |
Hyperhidrosis | 70.84 | 10.38 | 1527 | 661505 | 92561 | 55536474 |
Thyroid cancer | 68.67 | 10.38 | 172 | 662860 | 4944 | 55624091 |
Oedema peripheral | 68.21 | 10.38 | 2563 | 660469 | 168691 | 55460344 |
Weight decreased | 67.60 | 10.38 | 3475 | 659557 | 237239 | 55391796 |
Adrenocortical insufficiency acute | 67.05 | 10.38 | 86 | 662946 | 1430 | 55627605 |
Transient ischaemic attack | 66.03 | 10.38 | 645 | 662387 | 32932 | 55596103 |
Dry skin | 62.84 | 10.38 | 839 | 662193 | 46270 | 55582765 |
Sensitisation | 62.09 | 10.38 | 105 | 662927 | 2263 | 55626772 |
Diarrhoea | 62.03 | 10.38 | 8501 | 654531 | 630006 | 54999029 |
Panniculitis | 60.79 | 10.38 | 20 | 663012 | 9822 | 55619213 |
Hot flush | 60.61 | 10.38 | 828 | 662204 | 45898 | 55583137 |
Peripheral swelling | 60.25 | 10.38 | 2209 | 660823 | 232517 | 55396518 |
Malaise | 58.43 | 10.38 | 5061 | 657971 | 362799 | 55266236 |
Muscular weakness | 58.42 | 10.38 | 1628 | 661404 | 102824 | 55526211 |
Craniopharyngioma | 58.06 | 10.38 | 31 | 663001 | 127 | 55628908 |
Blood pressure increased | 56.43 | 10.38 | 2167 | 660865 | 143009 | 55486026 |
Pregnancy | 56.01 | 10.38 | 200 | 662832 | 32833 | 55596202 |
Bone marrow failure | 55.83 | 10.38 | 160 | 662872 | 28126 | 55600909 |
Anxiety | 55.09 | 10.38 | 2793 | 660239 | 190379 | 55438656 |
Nervousness | 54.93 | 10.38 | 553 | 662479 | 28462 | 55600573 |
Death | 54.78 | 10.38 | 3378 | 659654 | 338048 | 55290987 |
Insulin-like growth factor increased | 54.47 | 10.38 | 59 | 662973 | 812 | 55628223 |
Sinusitis | 54.22 | 10.38 | 1844 | 661188 | 195737 | 55433298 |
Dry mouth | 53.90 | 10.38 | 1059 | 661973 | 63146 | 55565889 |
Schizoaffective disorder | 53.87 | 10.38 | 112 | 662920 | 2837 | 55626198 |
Rheumatoid nodule | 52.95 | 10.38 | 58 | 662974 | 14799 | 55614236 |
Hypoglycaemia | 52.87 | 10.38 | 938 | 662094 | 54877 | 55574158 |
Headache | 52.62 | 10.38 | 7430 | 655602 | 551614 | 55077421 |
Thyroidectomy | 51.99 | 10.38 | 63 | 662969 | 986 | 55628049 |
Cardio-respiratory arrest | 51.70 | 10.38 | 410 | 662622 | 54911 | 55574124 |
Visual impairment | 51.66 | 10.38 | 1191 | 661841 | 73011 | 55556024 |
Blood parathyroid hormone decreased | 51.65 | 10.38 | 17 | 663015 | 8347 | 55620688 |
Adverse event | 51.02 | 10.38 | 412 | 662620 | 54964 | 55574071 |
Reaction to excipient | 50.86 | 10.38 | 69 | 662963 | 1215 | 55627820 |
Blood glucose increased | 50.71 | 10.38 | 1201 | 661831 | 73950 | 55555085 |
Insomnia | 49.87 | 10.38 | 2750 | 660282 | 189110 | 55439925 |
Hepatotoxicity | 48.68 | 10.38 | 195 | 662837 | 30958 | 55598077 |
Arrhythmia | 47.69 | 10.38 | 627 | 662405 | 34456 | 55594579 |
Myxoedema coma | 47.63 | 10.38 | 39 | 662993 | 367 | 55628668 |
Product monitoring error | 47.17 | 10.38 | 117 | 662915 | 3342 | 55625693 |
Flatulence | 47.15 | 10.38 | 570 | 662462 | 30718 | 55598317 |
Enthesopathy | 47.04 | 10.38 | 18 | 663014 | 8045 | 55620990 |
Gastrooesophageal reflux disease | 46.08 | 10.38 | 1296 | 661736 | 81961 | 55547074 |
Bone erosion | 45.51 | 10.38 | 66 | 662966 | 14908 | 55614127 |
Urinary tract infection | 45.11 | 10.38 | 3352 | 659680 | 237161 | 55391874 |
Thyroxine increased | 44.93 | 10.38 | 45 | 662987 | 562 | 55628473 |
Dysphonia | 44.87 | 10.38 | 719 | 662313 | 41228 | 55587807 |
Joint destruction | 44.74 | 10.38 | 4 | 663028 | 5051 | 55623984 |
Bone pain | 43.56 | 10.38 | 832 | 662200 | 49353 | 55579682 |
Thyroxine free increased | 43.44 | 10.38 | 52 | 662980 | 803 | 55628232 |
Oral pain | 43.18 | 10.38 | 487 | 662545 | 25806 | 55603229 |
Haemophagocytic lymphohistiocytosis | 43.03 | 10.38 | 30 | 663002 | 9542 | 55619493 |
Neurotoxicity | 42.91 | 10.38 | 75 | 662957 | 15720 | 55613315 |
Therapeutic drug monitoring analysis not performed | 42.87 | 10.38 | 56 | 662976 | 949 | 55628086 |
Cerebral haematoma | 42.81 | 10.38 | 110 | 662922 | 3213 | 55625822 |
Myxoedema | 42.57 | 10.38 | 22 | 663010 | 83 | 55628952 |
Disease progression | 41.94 | 10.38 | 931 | 662101 | 104242 | 55524793 |
Gait disturbance | 41.85 | 10.38 | 2338 | 660694 | 160983 | 55468052 |
Thyroid hormones increased | 41.54 | 10.38 | 35 | 662997 | 344 | 55628691 |
Transplant dysfunction | 41.35 | 10.38 | 4 | 663028 | 4742 | 55624293 |
Swollen tongue | 41.24 | 10.38 | 542 | 662490 | 29782 | 55599253 |
Neutropenia | 41.11 | 10.38 | 1486 | 661546 | 156681 | 55472354 |
Full blood count abnormal | 40.71 | 10.38 | 484 | 662548 | 25978 | 55603057 |
Device expulsion | 40.70 | 10.38 | 202 | 662830 | 30247 | 55598788 |
Amnesia | 40.56 | 10.38 | 769 | 662263 | 45553 | 55583482 |
Infective pulmonary exacerbation of cystic fibrosis | 40.20 | 10.38 | 23 | 663009 | 8134 | 55620901 |
Device difficult to use | 39.48 | 10.38 | 41 | 662991 | 10720 | 55618315 |
Red blood cell sedimentation rate | 39.26 | 10.38 | 3 | 663029 | 4305 | 55624730 |
Tri-iodothyronine decreased | 39.11 | 10.38 | 23 | 663009 | 118 | 55628917 |
Sedation | 39.01 | 10.38 | 602 | 662430 | 34252 | 55594783 |
Multiple organ dysfunction syndrome | 38.95 | 10.38 | 415 | 662617 | 52355 | 55576680 |
Therapeutic response decreased | 38.90 | 10.38 | 415 | 662617 | 52343 | 55576692 |
Acute kidney injury | 38.87 | 10.38 | 3317 | 659715 | 237446 | 55391589 |
Product solubility abnormal | 38.81 | 10.38 | 47 | 662985 | 735 | 55628300 |
C-reactive protein increased | 38.81 | 10.38 | 672 | 662360 | 78012 | 55551023 |
Retinitis | 38.33 | 10.38 | 3 | 663029 | 4221 | 55624814 |
Pulmonary malformation | 38.11 | 10.38 | 28 | 663004 | 221 | 55628814 |
Haematotoxicity | 38.05 | 10.38 | 26 | 663006 | 8357 | 55620678 |
Abdominal distension | 37.72 | 10.38 | 1189 | 661843 | 76437 | 55552598 |
Toxic epidermal necrolysis | 37.67 | 10.38 | 133 | 662899 | 21909 | 55607126 |
Diffuse alopecia | 37.63 | 10.38 | 42 | 662990 | 599 | 55628436 |
Angina pectoris | 37.62 | 10.38 | 499 | 662533 | 27477 | 55601558 |
Pathogen resistance | 37.40 | 10.38 | 12 | 663020 | 5988 | 55623047 |
Cardiac disorder | 37.22 | 10.38 | 753 | 662279 | 45134 | 55583901 |
Accidental exposure to product | 36.81 | 10.38 | 157 | 662875 | 24490 | 55604545 |
Decreased appetite | 36.75 | 10.38 | 3029 | 660003 | 216202 | 55412833 |
Hypersomnia | 36.70 | 10.38 | 323 | 662709 | 16018 | 55613017 |
Live birth | 36.46 | 10.38 | 114 | 662918 | 19491 | 55609544 |
Pituitary tumour recurrent | 36.31 | 10.38 | 19 | 663013 | 74 | 55628961 |
Anaphylactic reaction | 36.23 | 10.38 | 483 | 662549 | 58512 | 55570523 |
Breast cancer stage I | 36.19 | 10.38 | 14 | 663018 | 6216 | 55622819 |
Mucosal inflammation | 36.08 | 10.38 | 326 | 662706 | 42484 | 55586551 |
Device adhesion issue | 35.92 | 10.38 | 5 | 663027 | 4469 | 55624566 |
Product administration error | 35.90 | 10.38 | 391 | 662641 | 20538 | 55608497 |
Post transplant lymphoproliferative disorder | 35.73 | 10.38 | 6 | 663026 | 4666 | 55624369 |
Type 2 diabetes mellitus | 35.62 | 10.38 | 366 | 662666 | 46496 | 55582539 |
Ageusia | 35.54 | 10.38 | 260 | 662772 | 12191 | 55616844 |
Venoocclusive liver disease | 35.36 | 10.38 | 5 | 663027 | 4416 | 55624619 |
Bradycardia | 35.21 | 10.38 | 1043 | 661989 | 66461 | 55562574 |
Exophthalmos | 34.82 | 10.38 | 58 | 662974 | 1234 | 55627801 |
Memory impairment | 34.08 | 10.38 | 1294 | 661738 | 85263 | 55543772 |
Hypoacusis | 33.87 | 10.38 | 399 | 662633 | 21369 | 55607666 |
Disability | 33.59 | 10.38 | 86 | 662946 | 15694 | 55613341 |
Ejection fraction | 33.54 | 10.38 | 67 | 662965 | 1648 | 55627387 |
Haematochezia | 33.36 | 10.38 | 711 | 662321 | 43007 | 55586028 |
Blood thyroid stimulating hormone | 33.27 | 10.38 | 11 | 663021 | 6 | 55629029 |
Reversible airways obstruction | 33.19 | 10.38 | 59 | 662973 | 1325 | 55627710 |
Jaw disorder | 33.03 | 10.38 | 133 | 662899 | 4950 | 55624085 |
Eye irritation | 32.87 | 10.38 | 356 | 662676 | 18672 | 55610363 |
Suicide attempt | 32.85 | 10.38 | 481 | 662551 | 57355 | 55571680 |
Anti-cyclic citrullinated peptide antibody | 32.81 | 10.38 | 3 | 663029 | 3720 | 55625315 |
Breast cancer stage III | 32.80 | 10.38 | 22 | 663010 | 7141 | 55621894 |
Hip fracture | 32.57 | 10.38 | 472 | 662560 | 26501 | 55602534 |
Pain in extremity | 32.40 | 10.38 | 3989 | 659043 | 293442 | 55335593 |
Papillary thyroid cancer | 32.36 | 10.38 | 75 | 662957 | 2049 | 55626986 |
Polycystic ovaries | 32.18 | 10.38 | 99 | 662933 | 3215 | 55625820 |
Disorientation | 32.12 | 10.38 | 608 | 662424 | 36005 | 55593030 |
Liver function test abnormal | 32.07 | 10.38 | 734 | 662298 | 44937 | 55584098 |
Systemic infection | 32.06 | 10.38 | 98 | 662934 | 3171 | 55625864 |
Lactose intolerance | 31.93 | 10.38 | 86 | 662946 | 2586 | 55626449 |
Breast cancer stage II | 31.73 | 10.38 | 14 | 663018 | 5744 | 55623291 |
Pulmonary embolism | 31.56 | 10.38 | 1554 | 661478 | 105570 | 55523465 |
Deep vein thrombosis | 31.56 | 10.38 | 1156 | 661876 | 75821 | 55553214 |
Thyroid hormones decreased | 31.55 | 10.38 | 28 | 663004 | 297 | 55628738 |
Milk-alkali syndrome | 31.51 | 10.38 | 40 | 662992 | 658 | 55628377 |
Sickle cell anaemia with crisis | 31.44 | 10.38 | 10 | 663022 | 5018 | 55624017 |
Depression | 31.37 | 10.38 | 2496 | 660536 | 177621 | 55451414 |
Chest discomfort | 31.23 | 10.38 | 1444 | 661588 | 97413 | 55531622 |
Unintentional medical device removal | 31.14 | 10.38 | 14 | 663018 | 5680 | 55623355 |
Thyroxine abnormal | 31.08 | 10.38 | 9 | 663023 | 0 | 55629035 |
Hyperkalaemia | 31.06 | 10.38 | 802 | 662230 | 50063 | 55578972 |
Respiratory arrest | 30.97 | 10.38 | 222 | 662810 | 30403 | 55598632 |
Influenza like illness | 30.91 | 10.38 | 939 | 662093 | 60049 | 55568986 |
Renal disorder | 30.74 | 10.38 | 505 | 662527 | 29100 | 55599935 |
Malabsorption | 30.68 | 10.38 | 107 | 662925 | 3714 | 55625321 |
Multiple-drug resistance | 30.63 | 10.38 | 5 | 663027 | 3969 | 55625066 |
Septic shock | 30.50 | 10.38 | 518 | 662514 | 60317 | 55568718 |
Incorrect dose administered | 30.49 | 10.38 | 823 | 662209 | 51724 | 55577311 |
Product measured potency issue | 30.36 | 10.38 | 18 | 663014 | 94 | 55628941 |
Product taste abnormal | 30.24 | 10.38 | 68 | 662964 | 1820 | 55627215 |
Arthralgia | 30.00 | 10.38 | 5326 | 657706 | 496343 | 55132692 |
Ankylosing spondylitis | 29.95 | 10.38 | 44 | 662988 | 9886 | 55619149 |
Chest pain | 29.86 | 10.38 | 2610 | 660422 | 187187 | 55441848 |
Product odour abnormal | 29.78 | 10.38 | 50 | 662982 | 1071 | 55627964 |
International normalised ratio increased | 29.75 | 10.38 | 704 | 662328 | 43337 | 55585698 |
Eye swelling | 29.46 | 10.38 | 383 | 662649 | 20993 | 55608042 |
Carpal tunnel syndrome | 29.31 | 10.38 | 335 | 662697 | 17809 | 55611226 |
Juvenile idiopathic arthritis | 28.95 | 10.38 | 10 | 663022 | 4763 | 55624272 |
Gestational diabetes | 28.79 | 10.38 | 178 | 662854 | 7886 | 55621149 |
Papillitis | 28.70 | 10.38 | 11 | 663021 | 15 | 55629020 |
Soft tissue disorder | 28.60 | 10.38 | 113 | 662919 | 4169 | 55624866 |
Overdose | 28.47 | 10.38 | 990 | 662042 | 104840 | 55524195 |
Rhinitis allergic | 28.36 | 10.38 | 184 | 662848 | 8290 | 55620745 |
Product colour issue | 28.16 | 10.38 | 35 | 662997 | 563 | 55628472 |
Body height decreased | 28.08 | 10.38 | 195 | 662837 | 8990 | 55620045 |
Pancreatic neuroendocrine tumour | 28.03 | 10.38 | 30 | 663002 | 407 | 55628628 |
Blood glucose decreased | 28.01 | 10.38 | 346 | 662686 | 18741 | 55610294 |
Paraesthesia | 27.92 | 10.38 | 1839 | 661193 | 128675 | 55500360 |
Atrioventricular block | 27.80 | 10.38 | 157 | 662875 | 6730 | 55622305 |
Cerebrovascular accident | 27.58 | 10.38 | 1432 | 661600 | 97838 | 55531197 |
Inner ear disorder | 27.57 | 10.38 | 31 | 663001 | 446 | 55628589 |
Thyrotoxic crisis | 27.52 | 10.38 | 41 | 662991 | 790 | 55628245 |
Product physical issue | 27.50 | 10.38 | 117 | 662915 | 4465 | 55624570 |
Inflammation | 27.36 | 10.38 | 612 | 662420 | 68459 | 55560576 |
Impaired driving ability | 27.28 | 10.38 | 108 | 662924 | 3988 | 55625047 |
Stillbirth | 27.25 | 10.38 | 20 | 663012 | 6194 | 55622841 |
Lip swelling | 27.23 | 10.38 | 448 | 662584 | 25824 | 55603211 |
Autoimmune hepatitis | 27.13 | 10.38 | 173 | 662859 | 7748 | 55621287 |
Neutrophil count decreased | 27.04 | 10.38 | 418 | 662614 | 49404 | 55579631 |
Trichorrhexis | 27.03 | 10.38 | 49 | 662983 | 1118 | 55627917 |
Pollakiuria | 26.95 | 10.38 | 432 | 662600 | 24770 | 55604265 |
Adenovirus infection | 26.92 | 10.38 | 4 | 663028 | 3404 | 55625631 |
Choking | 26.91 | 10.38 | 190 | 662842 | 8807 | 55620228 |
Gastrointestinal toxicity | 26.75 | 10.38 | 20 | 663012 | 6136 | 55622899 |
Skin haemorrhage | 26.54 | 10.38 | 180 | 662852 | 8233 | 55620802 |
Feeling cold | 26.48 | 10.38 | 373 | 662659 | 20814 | 55608221 |
Anaemia | 26.48 | 10.38 | 3567 | 659465 | 263944 | 55365091 |
Foreign body in reproductive tract | 26.28 | 10.38 | 31 | 663001 | 471 | 55628564 |
Swelling face | 26.24 | 10.38 | 855 | 662177 | 55214 | 55573821 |
Low turnover osteopathy | 26.15 | 10.38 | 105 | 662927 | 3903 | 55625132 |
Pneumocystis jirovecii pneumonia | 26.00 | 10.38 | 96 | 662936 | 15605 | 55613430 |
Nephritic syndrome | 25.91 | 10.38 | 23 | 663009 | 244 | 55628791 |
Therapeutic product effect increased | 25.52 | 10.38 | 45 | 662987 | 1004 | 55628031 |
Hypertensive crisis | 25.37 | 10.38 | 265 | 662767 | 13771 | 55615264 |
Congenital absence of vertebra | 25.23 | 10.38 | 12 | 663020 | 36 | 55628999 |
Dementia | 25.16 | 10.38 | 311 | 662721 | 16847 | 55612188 |
Haematoma | 25.16 | 10.38 | 523 | 662509 | 31496 | 55597539 |
Tinnitus | 25.03 | 10.38 | 495 | 662537 | 29547 | 55599488 |
Tenosynovitis | 24.95 | 10.38 | 70 | 662962 | 12391 | 55616644 |
Gastritis | 24.77 | 10.38 | 559 | 662473 | 34143 | 55594892 |
Renal dysplasia | 24.71 | 10.38 | 18 | 663014 | 140 | 55628895 |
Somatic delusion | 24.60 | 10.38 | 32 | 663000 | 540 | 55628495 |
Cytomegalovirus infection reactivation | 24.47 | 10.38 | 4 | 663028 | 3172 | 55625863 |
Abortion spontaneous | 24.46 | 10.38 | 365 | 662667 | 43388 | 55585647 |
Macular degeneration | 24.38 | 10.38 | 127 | 662905 | 18781 | 55610254 |
Premature labour | 24.35 | 10.38 | 66 | 662966 | 11816 | 55617219 |
Head discomfort | 24.21 | 10.38 | 232 | 662800 | 11782 | 55617253 |
Premature baby | 24.20 | 10.38 | 130 | 662902 | 19075 | 55609960 |
Cataract | 24.12 | 10.38 | 782 | 662250 | 50465 | 55578570 |
Cardiac arrest | 24.01 | 10.38 | 804 | 662228 | 85510 | 55543525 |
Lung cyst | 23.88 | 10.38 | 23 | 663009 | 273 | 55628762 |
Thyroid cancer recurrent | 23.87 | 10.38 | 11 | 663021 | 30 | 55629005 |
Dyspnoea exertional | 23.82 | 10.38 | 827 | 662205 | 53862 | 55575173 |
Goitre | 23.80 | 10.38 | 129 | 662903 | 5444 | 55623591 |
Spinal stenosis | 23.66 | 10.38 | 261 | 662771 | 13753 | 55615282 |
Hypopituitarism | 23.60 | 10.38 | 43 | 662989 | 985 | 55628050 |
Insulin-like growth factor decreased | 23.55 | 10.38 | 26 | 663006 | 366 | 55628669 |
Blood loss anaemia | 23.54 | 10.38 | 173 | 662859 | 8124 | 55620911 |
Thrombotic microangiopathy | 23.52 | 10.38 | 47 | 662985 | 9364 | 55619671 |
Respiratory disorder | 23.49 | 10.38 | 271 | 662761 | 33686 | 55595349 |
Withdrawal syndrome | 23.46 | 10.38 | 326 | 662706 | 18136 | 55610899 |
Haemorrhoids | 23.38 | 10.38 | 351 | 662681 | 19855 | 55609180 |
Ischaemic stroke | 23.31 | 10.38 | 302 | 662730 | 16540 | 55612495 |
Presbyacusis | 23.20 | 10.38 | 3 | 663029 | 2835 | 55626200 |
Fatigue | 23.18 | 10.38 | 9947 | 653085 | 778605 | 54850430 |
Scleral discolouration | 23.18 | 10.38 | 26 | 663006 | 373 | 55628662 |
Pneumonia viral | 23.09 | 10.38 | 154 | 662878 | 7004 | 55622031 |
Oral discomfort | 23.01 | 10.38 | 173 | 662859 | 8182 | 55620853 |
Cardiac pacemaker insertion | 22.92 | 10.38 | 97 | 662935 | 3693 | 55625342 |
Product dispensing error | 22.86 | 10.38 | 187 | 662845 | 9077 | 55619958 |
Extremity contracture | 22.69 | 10.38 | 48 | 662984 | 1231 | 55627804 |
Tenderness | 22.51 | 10.38 | 348 | 662684 | 19807 | 55609228 |
Eye pain | 22.36 | 10.38 | 498 | 662534 | 30349 | 55598686 |
Hyperlipidaemia | 22.30 | 10.38 | 318 | 662714 | 17791 | 55611244 |
Arteriosclerosis coronary artery | 22.29 | 10.38 | 163 | 662869 | 7642 | 55621393 |
Listless | 22.26 | 10.38 | 75 | 662957 | 2557 | 55626478 |
Speech disorder | 22.26 | 10.38 | 589 | 662443 | 36904 | 55592131 |
Recalled product | 22.24 | 10.38 | 50 | 662982 | 1338 | 55627697 |
Gastrointestinal motility disorder | 22.21 | 10.38 | 112 | 662920 | 4594 | 55624441 |
Skin necrosis | 22.20 | 10.38 | 73 | 662959 | 12288 | 55616747 |
Thyrotoxic periodic paralysis | 22.07 | 10.38 | 9 | 663023 | 16 | 55629019 |
Ventricular hypertrophy | 22.07 | 10.38 | 86 | 662946 | 3152 | 55625883 |
Gallbladder disorder | 22.00 | 10.38 | 306 | 662726 | 17028 | 55612007 |
Product dose omission issue | 22.00 | 10.38 | 2744 | 660288 | 202009 | 55427026 |
Tooth fracture | 21.99 | 10.38 | 201 | 662831 | 10075 | 55618960 |
Small for dates baby | 21.86 | 10.38 | 91 | 662941 | 3439 | 55625596 |
Maternal exposure timing unspecified | 21.84 | 10.38 | 19 | 663013 | 5404 | 55623631 |
Coronary artery occlusion | 21.83 | 10.38 | 161 | 662871 | 7568 | 55621467 |
Coma | 21.83 | 10.38 | 535 | 662497 | 59120 | 55569915 |
Pelvic fracture | 21.80 | 10.38 | 230 | 662802 | 11983 | 55617052 |
Graft versus host disease in skin | 21.79 | 10.38 | 3 | 663029 | 2704 | 55626331 |
Hypophysitis | 21.78 | 10.38 | 55 | 662977 | 1589 | 55627446 |
Sprue-like enteropathy | 21.63 | 10.38 | 30 | 663002 | 540 | 55628495 |
Somnolence | 21.49 | 10.38 | 2219 | 660813 | 161194 | 55467841 |
Disseminated intravascular coagulation | 21.48 | 10.38 | 123 | 662909 | 17762 | 55611273 |
Diverticulum | 21.47 | 10.38 | 212 | 662820 | 10854 | 55618181 |
Dry eye | 21.47 | 10.38 | 562 | 662470 | 35154 | 55593881 |
Broncholithiasis | 21.22 | 10.38 | 19 | 663013 | 204 | 55628831 |
Vitamin D deficiency | 21.16 | 10.38 | 228 | 662804 | 11942 | 55617093 |
Micturition urgency | 21.00 | 10.38 | 176 | 662856 | 8605 | 55620430 |
Glomerular filtration rate decreased | 20.99 | 10.38 | 230 | 662802 | 12099 | 55616936 |
Thrombosis | 20.96 | 10.38 | 878 | 662154 | 58549 | 55570486 |
Lethargy | 20.96 | 10.38 | 772 | 662260 | 50669 | 55578366 |
Hyperglycaemia | 20.92 | 10.38 | 595 | 662437 | 37686 | 55591349 |
Ecchymosis | 20.88 | 10.38 | 200 | 662832 | 10156 | 55618879 |
Rapid eye movement sleep behaviour disorder | 20.80 | 10.38 | 18 | 663014 | 184 | 55628851 |
Acute graft versus host disease in skin | 20.69 | 10.38 | 6 | 663026 | 3196 | 55625839 |
Dyspnoea | 20.62 | 10.38 | 7520 | 655512 | 585057 | 55043978 |
Bundle branch block left | 20.60 | 10.38 | 137 | 662895 | 6225 | 55622810 |
Dislocation of vertebra | 20.59 | 10.38 | 20 | 663012 | 5395 | 55623640 |
Labelled drug-drug interaction medication error | 20.59 | 10.38 | 218 | 662814 | 11368 | 55617667 |
Substance abuse | 20.58 | 10.38 | 14 | 663018 | 4511 | 55624524 |
Head injury | 20.54 | 10.38 | 412 | 662620 | 24654 | 55604381 |
Cytomegalovirus viraemia | 20.54 | 10.38 | 18 | 663014 | 5102 | 55623933 |
Muscle spasticity | 20.52 | 10.38 | 144 | 662888 | 19816 | 55609219 |
Drug use disorder | 20.51 | 10.38 | 15 | 663017 | 4654 | 55624381 |
Drug interaction | 20.50 | 10.38 | 2795 | 660237 | 206960 | 55422075 |
Graft versus host disease | 20.50 | 10.38 | 30 | 663002 | 6751 | 55622284 |
Congenital renal cyst | 20.46 | 10.38 | 7 | 663025 | 5 | 55629030 |
Therapeutic product effect variable | 20.37 | 10.38 | 43 | 662989 | 1101 | 55627934 |
Burning sensation | 20.37 | 10.38 | 733 | 662299 | 47963 | 55581072 |
Hypotension | 20.35 | 10.38 | 3303 | 659729 | 247205 | 55381830 |
X-ray abnormal | 20.33 | 10.38 | 13 | 663019 | 4328 | 55624707 |
Arterial occlusive disease | 20.32 | 10.38 | 121 | 662911 | 5289 | 55623746 |
Urinary incontinence | 20.31 | 10.38 | 474 | 662558 | 29111 | 55599924 |
Full blood count decreased | 20.22 | 10.38 | 387 | 662645 | 22962 | 55606073 |
Vital capacity decreased | 20.20 | 10.38 | 46 | 662986 | 1242 | 55627793 |
Cardiotoxicity | 20.18 | 10.38 | 37 | 662995 | 7613 | 55621422 |
Blood creatine abnormal | 20.16 | 10.38 | 14 | 663018 | 100 | 55628935 |
Body temperature increased | 20.07 | 10.38 | 283 | 662749 | 33959 | 55595076 |
Pituitary tumour benign | 20.04 | 10.38 | 59 | 662973 | 1869 | 55627166 |
Intervertebral disc protrusion | 19.98 | 10.38 | 363 | 662669 | 21331 | 55607704 |
Electrocardiogram ST-T segment abnormal | 19.96 | 10.38 | 21 | 663011 | 279 | 55628756 |
Intentional self-injury | 19.90 | 10.38 | 193 | 662839 | 24799 | 55604236 |
Thyroxine free decreased | 19.87 | 10.38 | 31 | 663001 | 623 | 55628412 |
Blood insulin increased | 19.67 | 10.38 | 15 | 663017 | 126 | 55628909 |
Chromaturia | 19.64 | 10.38 | 271 | 662761 | 15054 | 55613981 |
Hiatus hernia | 19.59 | 10.38 | 333 | 662699 | 19319 | 55609716 |
Thinking abnormal | 19.56 | 10.38 | 191 | 662841 | 9750 | 55619285 |
Incorrect route of product administration | 19.50 | 10.38 | 159 | 662873 | 21170 | 55607865 |
Adenomatous polyposis coli | 19.49 | 10.38 | 10 | 663022 | 37 | 55628998 |
Chronic graft versus host disease | 19.45 | 10.38 | 7 | 663025 | 3249 | 55625786 |
Respiratory tract malformation | 19.42 | 10.38 | 16 | 663016 | 152 | 55628883 |
Tongue discomfort | 19.36 | 10.38 | 60 | 662972 | 1956 | 55627079 |
Subdural hygroma | 19.31 | 10.38 | 19 | 663013 | 232 | 55628803 |
Blood sodium decreased | 19.28 | 10.38 | 370 | 662662 | 21964 | 55607071 |
Dyspepsia | 19.28 | 10.38 | 1184 | 661848 | 82287 | 55546748 |
Change of bowel habit | 18.99 | 10.38 | 61 | 662971 | 2028 | 55627007 |
Neuromyopathy | 18.90 | 10.38 | 29 | 663003 | 574 | 55628461 |
Foetal death | 18.90 | 10.38 | 46 | 662986 | 8541 | 55620494 |
Pulmonary tuberculosis | 18.87 | 10.38 | 15 | 663017 | 4461 | 55624574 |
Feeling jittery | 18.83 | 10.38 | 221 | 662811 | 11825 | 55617210 |
Blood calcium increased | 18.74 | 10.38 | 162 | 662870 | 7992 | 55621043 |
Lymphadenectomy | 18.74 | 10.38 | 37 | 662995 | 902 | 55628133 |
Hypertension | 18.74 | 10.38 | 3211 | 659821 | 241067 | 55387968 |
Persistent depressive disorder | 18.73 | 10.38 | 36 | 662996 | 860 | 55628175 |
Abortion induced | 18.71 | 10.38 | 55 | 662977 | 9590 | 55619445 |
Anosmia | 18.68 | 10.38 | 102 | 662930 | 4317 | 55624718 |
Nephrectomy | 18.67 | 10.38 | 43 | 662989 | 1170 | 55627865 |
Exposure to toxic agent | 18.66 | 10.38 | 10 | 663022 | 3668 | 55625367 |
Red blood cell sedimentation rate increased | 18.63 | 10.38 | 311 | 662721 | 36312 | 55592723 |
Therapy partial responder | 18.51 | 10.38 | 40 | 662992 | 7745 | 55621290 |
Paradoxical drug reaction | 18.50 | 10.38 | 11 | 663021 | 3809 | 55625226 |
Poisoning deliberate | 18.42 | 10.38 | 58 | 662974 | 9895 | 55619140 |
Glycosylated haemoglobin increased | 18.42 | 10.38 | 207 | 662825 | 10958 | 55618077 |
Bronchopulmonary aspergillosis | 18.40 | 10.38 | 44 | 662988 | 8220 | 55620815 |
Cytokine release syndrome | 18.33 | 10.38 | 66 | 662966 | 10809 | 55618226 |
Genital swelling | 18.32 | 10.38 | 14 | 663018 | 118 | 55628917 |
Prescribed overdose | 18.26 | 10.38 | 171 | 662861 | 22125 | 55606910 |
Back pain | 18.24 | 10.38 | 3118 | 659914 | 234052 | 55394983 |
Dysstasia | 18.23 | 10.38 | 325 | 662707 | 19029 | 55610006 |
Cardiac failure congestive | 18.21 | 10.38 | 1233 | 661799 | 86487 | 55542548 |
Muscle fatigue | 18.19 | 10.38 | 65 | 662967 | 2284 | 55626751 |
Endocrine ophthalmopathy | 18.18 | 10.38 | 26 | 663006 | 482 | 55628553 |
Cystitis haemorrhagic | 18.15 | 10.38 | 12 | 663020 | 3925 | 55625110 |
Thyroxine decreased | 18.05 | 10.38 | 29 | 663003 | 598 | 55628437 |
Dilatation atrial | 18.05 | 10.38 | 56 | 662976 | 1827 | 55627208 |
Rectal haemorrhage | 18.04 | 10.38 | 627 | 662405 | 40840 | 55588195 |
Epstein-Barr virus infection | 18.04 | 10.38 | 38 | 662994 | 7425 | 55621610 |
Neutropenic sepsis | 17.94 | 10.38 | 105 | 662927 | 15080 | 55613955 |
Eating disorder | 17.84 | 10.38 | 292 | 662740 | 16813 | 55612222 |
Abnormal dreams | 17.83 | 10.38 | 183 | 662849 | 9466 | 55619569 |
Foot deformity | 17.73 | 10.38 | 187 | 662845 | 23638 | 55605397 |
Aortic valve incompetence | 17.66 | 10.38 | 120 | 662912 | 5492 | 55623543 |
Diabetes mellitus inadequate control | 17.42 | 10.38 | 246 | 662786 | 13734 | 55615301 |
Pancreatitis acute | 17.39 | 10.38 | 403 | 662629 | 24721 | 55604314 |
Blood growth hormone increased | 17.38 | 10.38 | 24 | 663008 | 430 | 55628605 |
Drug level changed | 17.38 | 10.38 | 17 | 663015 | 206 | 55628829 |
Vessel puncture site haemorrhage | 17.36 | 10.38 | 13 | 663019 | 106 | 55628929 |
Application site erythema | 17.35 | 10.38 | 103 | 662929 | 4497 | 55624538 |
Supraventricular extrasystoles | 17.35 | 10.38 | 95 | 662937 | 4025 | 55625010 |
Neonatal thyrotoxicosis | 17.27 | 10.38 | 5 | 663027 | 0 | 55629035 |
Hair texture abnormal | 17.24 | 10.38 | 91 | 662941 | 3801 | 55625234 |
Adverse drug reaction | 17.11 | 10.38 | 611 | 662421 | 64521 | 55564514 |
Bundle branch block right | 17.08 | 10.38 | 105 | 662927 | 4642 | 55624393 |
Temperature intolerance | 17.07 | 10.38 | 157 | 662875 | 7883 | 55621152 |
Femur fracture | 17.06 | 10.38 | 594 | 662438 | 38701 | 55590334 |
Arrhythmia neonatal | 17.02 | 10.38 | 9 | 663023 | 36 | 55628999 |
Diabetes mellitus | 17.01 | 10.38 | 772 | 662260 | 51963 | 55577072 |
Oropharyngeal swelling | 17.00 | 10.38 | 34 | 662998 | 837 | 55628198 |
Product residue present | 16.99 | 10.38 | 89 | 662943 | 3706 | 55625329 |
International normalised ratio abnormal | 16.94 | 10.38 | 75 | 662957 | 2913 | 55626122 |
Anaemia postoperative | 16.90 | 10.38 | 60 | 662972 | 2101 | 55626934 |
Joint laxity | 16.84 | 10.38 | 4 | 663028 | 2435 | 55626600 |
Exposure via ingestion | 16.83 | 10.38 | 6 | 663026 | 2802 | 55626233 |
Tooth dislocation | 16.82 | 10.38 | 8 | 663024 | 24 | 55629011 |
Sleep apnoea syndrome | 16.82 | 10.38 | 414 | 662618 | 25647 | 55603388 |
Scar | 16.81 | 10.38 | 222 | 662810 | 12211 | 55616824 |
Product packaging issue | 16.81 | 10.38 | 37 | 662995 | 976 | 55628059 |
Skin ulcer | 16.77 | 10.38 | 337 | 662695 | 38271 | 55590764 |
Skin abrasion | 16.75 | 10.38 | 164 | 662868 | 8377 | 55620658 |
Fear of injection | 16.75 | 10.38 | 32 | 663000 | 6483 | 55622552 |
Starvation ketoacidosis | 16.73 | 10.38 | 11 | 663021 | 71 | 55628964 |
Depressed level of consciousness | 16.69 | 10.38 | 819 | 662213 | 55614 | 55573421 |
Hyperchromic anaemia | 16.65 | 10.38 | 9 | 663023 | 38 | 55628997 |
Dysuria | 16.62 | 10.38 | 477 | 662555 | 30252 | 55598783 |
Abdominal pain | 16.59 | 10.38 | 3371 | 659661 | 255434 | 55373601 |
No adverse event | 16.56 | 10.38 | 315 | 662717 | 36059 | 55592976 |
Lymph node calcification | 16.55 | 10.38 | 19 | 663013 | 280 | 55628755 |
Eyelid oedema | 16.53 | 10.38 | 182 | 662850 | 9586 | 55619449 |
Injection site reaction | 16.49 | 10.38 | 489 | 662543 | 52758 | 55576277 |
Mitral valve incompetence | 16.45 | 10.38 | 303 | 662729 | 17850 | 55611185 |
Abnormal weight gain | 16.36 | 10.38 | 47 | 662985 | 1468 | 55627567 |
Blood test abnormal | 16.35 | 10.38 | 226 | 662806 | 12558 | 55616477 |
Peripheral coldness | 16.33 | 10.38 | 200 | 662832 | 10811 | 55618224 |
Erythema dyschromicum perstans | 16.32 | 10.38 | 10 | 663022 | 56 | 55628979 |
Labile hypertension | 16.31 | 10.38 | 24 | 663008 | 457 | 55628578 |
Drug dependence | 16.30 | 10.38 | 178 | 662854 | 22355 | 55606680 |
Tension | 16.28 | 10.38 | 73 | 662959 | 2851 | 55626184 |
Hypocalcaemia | 16.27 | 10.38 | 449 | 662583 | 28311 | 55600724 |
Bladder disorder | 16.19 | 10.38 | 155 | 662877 | 7869 | 55621166 |
Visual field defect | 16.17 | 10.38 | 125 | 662907 | 5964 | 55623071 |
Cerebellar haematoma | 16.16 | 10.38 | 21 | 663011 | 354 | 55628681 |
Seronegative arthritis | 16.14 | 10.38 | 6 | 663026 | 2730 | 55626305 |
Spondylolisthesis | 16.14 | 10.38 | 80 | 662952 | 3259 | 55625776 |
Pharyngitis | 16.13 | 10.38 | 140 | 662892 | 18398 | 55610637 |
Premature delivery | 16.09 | 10.38 | 223 | 662809 | 26837 | 55602198 |
Diabetic ketoacidosis | 16.08 | 10.38 | 312 | 662720 | 18559 | 55610476 |
Throat clearing | 16.08 | 10.38 | 47 | 662985 | 1483 | 55627552 |
Skin exfoliation | 16.07 | 10.38 | 558 | 662474 | 36342 | 55592693 |
Aortic intramural haematoma | 16.05 | 10.38 | 10 | 663022 | 58 | 55628977 |
Thyroid atrophy | 16.03 | 10.38 | 7 | 663025 | 16 | 55629019 |
Anxiety disorder | 16.03 | 10.38 | 88 | 662944 | 3732 | 55625303 |
Eructation | 16.03 | 10.38 | 148 | 662884 | 7440 | 55621595 |
Retrograde amnesia | 16.02 | 10.38 | 23 | 663009 | 428 | 55628607 |
Blood iron abnormal | 15.97 | 10.38 | 10 | 663022 | 3367 | 55625668 |
Traumatic ulcer | 15.96 | 10.38 | 9 | 663023 | 42 | 55628993 |
Thyroid cancer metastatic | 15.91 | 10.38 | 13 | 663019 | 122 | 55628913 |
Faeces discoloured | 15.87 | 10.38 | 285 | 662747 | 16711 | 55612324 |
Poor quality product administered | 15.86 | 10.38 | 72 | 662960 | 2827 | 55626208 |
Atrioventricular block first degree | 15.86 | 10.38 | 135 | 662897 | 6630 | 55622405 |
Aplastic anaemia | 15.85 | 10.38 | 53 | 662979 | 8875 | 55620160 |
Mood altered | 15.85 | 10.38 | 233 | 662799 | 13122 | 55615913 |
Breast cancer female | 15.84 | 10.38 | 83 | 662949 | 12255 | 55616780 |
Thirst | 15.83 | 10.38 | 200 | 662832 | 10890 | 55618145 |
Lymphoproliferative disorder | 15.71 | 10.38 | 8 | 663024 | 3020 | 55626015 |
Insulin autoimmune syndrome | 15.69 | 10.38 | 11 | 663021 | 80 | 55628955 |
Hormone level abnormal | 15.68 | 10.38 | 61 | 662971 | 2234 | 55626801 |
Device use error | 15.66 | 10.38 | 25 | 663007 | 5431 | 55623604 |
Rib deformity | 15.66 | 10.38 | 16 | 663016 | 205 | 55628830 |
Thyroglobulin increased | 15.64 | 10.38 | 9 | 663023 | 44 | 55628991 |
Musculoskeletal disorder | 15.61 | 10.38 | 147 | 662885 | 19000 | 55610035 |
Pituitary tumour | 15.61 | 10.38 | 33 | 662999 | 846 | 55628189 |
Blood triglycerides increased | 15.58 | 10.38 | 208 | 662824 | 11469 | 55617566 |
Wrist fracture | 15.55 | 10.38 | 213 | 662819 | 11813 | 55617222 |
Cholelithiasis | 15.53 | 10.38 | 590 | 662442 | 38874 | 55590161 |
Gingival disorder | 15.50 | 10.38 | 79 | 662953 | 3254 | 55625781 |
Visual acuity reduced | 15.46 | 10.38 | 336 | 662696 | 20390 | 55608645 |
Drug eruption | 15.43 | 10.38 | 212 | 662820 | 25551 | 55603484 |
Psoriasis | 15.39 | 10.38 | 1280 | 661752 | 91412 | 55537623 |
Gastrointestinal tract irritation | 15.37 | 10.38 | 23 | 663009 | 445 | 55628590 |
Sensation of foreign body | 15.36 | 10.38 | 92 | 662940 | 4030 | 55625005 |
Pleural fibrosis | 15.34 | 10.38 | 11 | 663021 | 3448 | 55625587 |
Labyrinthitis | 15.34 | 10.38 | 60 | 662972 | 2203 | 55626832 |
Frontotemporal dementia | 15.26 | 10.38 | 20 | 663012 | 340 | 55628695 |
Limb deformity | 15.26 | 10.38 | 14 | 663018 | 3881 | 55625154 |
Piloerection | 15.22 | 10.38 | 20 | 663012 | 341 | 55628694 |
Magnetic resonance imaging thoracic abnormal | 15.21 | 10.38 | 7 | 663025 | 19 | 55629016 |
Hair growth abnormal | 15.19 | 10.38 | 68 | 662964 | 2654 | 55626381 |
Endocrine disorder | 15.17 | 10.38 | 27 | 663005 | 607 | 55628428 |
Dystonia | 15.15 | 10.38 | 85 | 662947 | 12336 | 55616699 |
Haemoglobin decreased | 15.09 | 10.38 | 1803 | 661229 | 132334 | 55496701 |
Skin toxicity | 15.04 | 10.38 | 16 | 663016 | 4137 | 55624898 |
Orthostatic intolerance | 15.03 | 10.38 | 37 | 662995 | 1052 | 55627983 |
Multiple drug therapy | 15.02 | 10.38 | 69 | 662963 | 2723 | 55626312 |
Loss of consciousness | 14.96 | 10.38 | 1489 | 661543 | 107860 | 55521175 |
Graft versus host disease in gastrointestinal tract | 14.90 | 10.38 | 8 | 663024 | 2931 | 55626104 |
Aspergillus infection | 14.90 | 10.38 | 42 | 662990 | 7423 | 55621612 |
Transcription medication error | 14.87 | 10.38 | 15 | 663017 | 189 | 55628846 |
Rhabdomyolysis | 14.86 | 10.38 | 603 | 662429 | 40055 | 55588980 |
Hepatitis B reactivation | 14.84 | 10.38 | 5 | 663027 | 2419 | 55626616 |
Rectourethral fistula | 14.76 | 10.38 | 8 | 663024 | 34 | 55629001 |
Bone formation increased | 14.75 | 10.38 | 14 | 663018 | 163 | 55628872 |
Gingival pain | 14.73 | 10.38 | 127 | 662905 | 6261 | 55622774 |
Urine odour abnormal | 14.72 | 10.38 | 119 | 662913 | 5755 | 55623280 |
Nocturia | 14.71 | 10.38 | 138 | 662894 | 6968 | 55622067 |
Nasal obstruction | 14.68 | 10.38 | 40 | 662992 | 1211 | 55627824 |
Oesophagitis | 14.67 | 10.38 | 240 | 662792 | 13817 | 55615218 |
Increased tendency to bruise | 14.67 | 10.38 | 178 | 662854 | 9600 | 55619435 |
Metastatic renal cell carcinoma | 14.64 | 10.38 | 35 | 662997 | 976 | 55628059 |
Lupus nephritis | 14.64 | 10.38 | 7 | 663025 | 2740 | 55626295 |
Body height below normal | 14.61 | 10.38 | 3 | 663029 | 2020 | 55627015 |
Neonatal tachypnoea | 14.61 | 10.38 | 9 | 663023 | 51 | 55628984 |
Neck injury | 14.59 | 10.38 | 51 | 662981 | 1772 | 55627263 |
Arteriosclerosis | 14.58 | 10.38 | 173 | 662859 | 9280 | 55619755 |
Posterior reversible encephalopathy syndrome | 14.58 | 10.38 | 119 | 662913 | 15841 | 55613194 |
Body height increased | 14.47 | 10.38 | 9 | 663023 | 52 | 55628983 |
Increased appetite | 14.43 | 10.38 | 162 | 662870 | 8573 | 55620462 |
Mean cell haemoglobin concentration increased | 14.43 | 10.38 | 23 | 663009 | 471 | 55628564 |
Gout | 14.42 | 10.38 | 213 | 662819 | 12008 | 55617027 |
Adenoiditis | 14.41 | 10.38 | 8 | 663024 | 36 | 55628999 |
Coombs positive haemolytic anaemia | 14.41 | 10.38 | 19 | 663013 | 325 | 55628710 |
Basedow's disease | 14.37 | 10.38 | 18 | 663014 | 292 | 55628743 |
Therapeutic response changed | 14.37 | 10.38 | 32 | 663000 | 851 | 55628184 |
Diffuse large B-cell lymphoma | 14.35 | 10.38 | 39 | 662993 | 6977 | 55622058 |
Anti-thyroid antibody positive | 14.35 | 10.38 | 21 | 663011 | 398 | 55628637 |
Carotid artery stenosis | 14.28 | 10.38 | 103 | 662929 | 4807 | 55624228 |
Temperature regulation disorder | 14.27 | 10.38 | 19 | 663013 | 4449 | 55624586 |
Tuberculosis | 14.26 | 10.38 | 74 | 662958 | 10955 | 55618080 |
Status epilepticus | 14.24 | 10.38 | 112 | 662920 | 15029 | 55614006 |
Sputum culture positive | 14.22 | 10.38 | 49 | 662983 | 1690 | 55627345 |
Nephropathy toxic | 14.21 | 10.38 | 52 | 662980 | 8475 | 55620560 |
Amniotic fluid volume increased | 14.20 | 10.38 | 13 | 663019 | 144 | 55628891 |
Petechiae | 14.13 | 10.38 | 224 | 662808 | 12815 | 55616220 |
Open reduction of fracture | 14.12 | 10.38 | 37 | 662995 | 1094 | 55627941 |
Dysarthria | 14.10 | 10.38 | 585 | 662447 | 38965 | 55590070 |
Acute myocardial infarction | 14.10 | 10.38 | 463 | 662569 | 29930 | 55599105 |
Injection site mass | 14.09 | 10.38 | 277 | 662755 | 16516 | 55612519 |
Rectal polyp | 14.08 | 10.38 | 37 | 662995 | 1096 | 55627939 |
Adjustment disorder with depressed mood | 14.07 | 10.38 | 24 | 663008 | 5079 | 55623956 |
Upper limb fracture | 14.07 | 10.38 | 282 | 662750 | 16873 | 55612162 |
Lipoma | 14.06 | 10.38 | 58 | 662974 | 2183 | 55626852 |
Injection site swelling | 14.05 | 10.38 | 398 | 662634 | 43180 | 55585855 |
Groin pain | 14.00 | 10.38 | 170 | 662862 | 9170 | 55619865 |
Facet joint syndrome | 14.00 | 10.38 | 37 | 662995 | 6680 | 55622355 |
Myositis | 13.97 | 10.38 | 157 | 662875 | 8311 | 55620724 |
Tri-iodothyronine free decreased | 13.96 | 10.38 | 18 | 663014 | 301 | 55628734 |
Cystic fibrosis | 13.95 | 10.38 | 12 | 663020 | 3432 | 55625603 |
Retinal artery embolism | 13.95 | 10.38 | 9 | 663023 | 56 | 55628979 |
Cerebral haemorrhage | 13.84 | 10.38 | 438 | 662594 | 28168 | 55600867 |
Optic nerve compression | 13.81 | 10.38 | 4 | 663028 | 0 | 55629035 |
Blood pressure inadequately controlled | 13.80 | 10.38 | 96 | 662936 | 4428 | 55624607 |
Granulocytopenia | 13.80 | 10.38 | 109 | 662923 | 5235 | 55623800 |
Atrial septal defect | 13.79 | 10.38 | 127 | 662905 | 6379 | 55622656 |
Deafness transitory | 13.78 | 10.38 | 3 | 663029 | 1939 | 55627096 |
Anaemia vitamin B12 deficiency | 13.78 | 10.38 | 19 | 663013 | 340 | 55628695 |
Expired product administered | 13.78 | 10.38 | 113 | 662919 | 5489 | 55623546 |
Idiosyncratic drug reaction | 13.76 | 10.38 | 28 | 663004 | 698 | 55628337 |
Vitello-intestinal duct remnant | 13.76 | 10.38 | 8 | 663024 | 40 | 55628995 |
Hypotensive transfusion reaction | 13.76 | 10.38 | 8 | 663024 | 40 | 55628995 |
Aphasia | 13.76 | 10.38 | 462 | 662570 | 29953 | 55599082 |
Ejection fraction abnormal | 13.75 | 10.38 | 36 | 662996 | 1064 | 55627971 |
Carcinoid tumour of the stomach | 13.72 | 10.38 | 13 | 663019 | 151 | 55628884 |
Hypogammaglobulinaemia | 13.70 | 10.38 | 35 | 662997 | 6391 | 55622644 |
Hyperadrenalism | 13.66 | 10.38 | 6 | 663026 | 14 | 55629021 |
Intervertebral disc degeneration | 13.65 | 10.38 | 240 | 662792 | 14014 | 55615021 |
Lupus vulgaris | 13.65 | 10.38 | 3 | 663029 | 1926 | 55627109 |
Restlessness | 13.64 | 10.38 | 410 | 662622 | 26176 | 55602859 |
Lymphocyte count decreased | 13.64 | 10.38 | 239 | 662793 | 27700 | 55601335 |
Acute hepatic failure | 13.64 | 10.38 | 127 | 662905 | 16451 | 55612584 |
Hypoglycaemic unconsciousness | 13.60 | 10.38 | 28 | 663004 | 704 | 55628331 |
Anaemia folate deficiency | 13.60 | 10.38 | 14 | 663018 | 181 | 55628854 |
Ophthalmic vein thrombosis | 13.60 | 10.38 | 15 | 663017 | 211 | 55628824 |
Intramedullary rod insertion | 13.60 | 10.38 | 54 | 662978 | 1997 | 55627038 |
Breast discomfort | 13.57 | 10.38 | 21 | 663011 | 419 | 55628616 |
Oesophageal achalasia | 13.57 | 10.38 | 21 | 663011 | 419 | 55628616 |
Abdominal pain upper | 13.56 | 10.38 | 2343 | 660689 | 175970 | 55453065 |
Malignant melanoma | 13.51 | 10.38 | 189 | 662843 | 10530 | 55618505 |
Sepsis | 13.50 | 10.38 | 1441 | 661591 | 138399 | 55490636 |
Jaundice | 13.50 | 10.38 | 419 | 662613 | 26875 | 55602160 |
Pneumonia aspiration | 13.46 | 10.38 | 285 | 662747 | 32126 | 55596909 |
Electrocardiogram abnormal | 13.44 | 10.38 | 151 | 662881 | 7993 | 55621042 |
Sleep disorder due to a general medical condition | 13.43 | 10.38 | 165 | 662867 | 8925 | 55620110 |
Injury | 13.42 | 10.38 | 572 | 662460 | 59279 | 55569756 |
Mucormycosis | 13.42 | 10.38 | 8 | 663024 | 2766 | 55626269 |
Cold sweat | 13.41 | 10.38 | 192 | 662840 | 10751 | 55618284 |
Recalled product administered | 13.41 | 10.38 | 22 | 663010 | 462 | 55628573 |
Retching | 13.39 | 10.38 | 229 | 662803 | 13301 | 55615734 |
Urine sodium decreased | 13.39 | 10.38 | 13 | 663019 | 156 | 55628879 |
Poisoning | 13.39 | 10.38 | 92 | 662940 | 12721 | 55616314 |
Coordination abnormal | 13.37 | 10.38 | 216 | 662816 | 12405 | 55616630 |
Oesophageal disorder | 13.34 | 10.38 | 56 | 662976 | 2124 | 55626911 |
BK virus infection | 13.26 | 10.38 | 10 | 663022 | 3054 | 55625981 |
Impatience | 13.26 | 10.38 | 19 | 663013 | 353 | 55628682 |
Spinal osteoarthritis | 13.23 | 10.38 | 247 | 662785 | 14589 | 55614446 |
Decreased bronchial secretion | 13.22 | 10.38 | 9 | 663023 | 62 | 55628973 |
Anal prolapse | 13.21 | 10.38 | 10 | 663022 | 83 | 55628952 |
Oesophageal obstruction | 13.18 | 10.38 | 22 | 663010 | 469 | 55628566 |
Product coating issue | 13.17 | 10.38 | 8 | 663024 | 44 | 55628991 |
Tooth discolouration | 13.12 | 10.38 | 31 | 663001 | 858 | 55628177 |
Blood pressure orthostatic decreased | 13.11 | 10.38 | 9 | 663023 | 63 | 55628972 |
Lactic acidosis | 13.10 | 10.38 | 525 | 662507 | 34821 | 55594214 |
Suspected suicide | 13.07 | 10.38 | 28 | 663004 | 5438 | 55623597 |
Lumbar radiculopathy | 13.00 | 10.38 | 50 | 662982 | 1821 | 55627214 |
Limb discomfort | 12.98 | 10.38 | 408 | 662624 | 26214 | 55602821 |
Inappropriate affect | 12.96 | 10.38 | 30 | 663002 | 819 | 55628216 |
Product blister packaging issue | 12.94 | 10.38 | 13 | 663019 | 163 | 55628872 |
Hemiparesis | 12.87 | 10.38 | 338 | 662694 | 21152 | 55607883 |
Hepatojugular reflux | 12.86 | 10.38 | 6 | 663026 | 17 | 55629018 |
Primary hypothyroidism | 12.84 | 10.38 | 10 | 663022 | 87 | 55628948 |
Tooth disorder | 12.83 | 10.38 | 393 | 662639 | 25160 | 55603875 |
Multiple allergies | 12.80 | 10.38 | 184 | 662848 | 10312 | 55618723 |
Agitation neonatal | 12.79 | 10.38 | 22 | 663010 | 481 | 55628554 |
Sciatica | 12.78 | 10.38 | 399 | 662633 | 25611 | 55603424 |
Irritability | 12.78 | 10.38 | 447 | 662585 | 29141 | 55599894 |
Electrocardiogram change | 12.73 | 10.38 | 25 | 663007 | 607 | 55628428 |
Wrong patient received product | 12.70 | 10.38 | 55 | 662977 | 2116 | 55626919 |
Overgrowth bacterial | 12.66 | 10.38 | 10 | 663022 | 89 | 55628946 |
Rheumatoid lung | 12.65 | 10.38 | 11 | 663021 | 3129 | 55625906 |
Gastrointestinal haemorrhage | 12.64 | 10.38 | 1049 | 661983 | 74902 | 55554133 |
Eye disorder | 12.63 | 10.38 | 323 | 662709 | 20129 | 55608906 |
Energy increased | 12.59 | 10.38 | 58 | 662974 | 2292 | 55626743 |
Arteriovenous malformation | 12.56 | 10.38 | 39 | 662993 | 1273 | 55627762 |
Parathyroid gland enlargement | 12.53 | 10.38 | 7 | 663025 | 32 | 55629003 |
Congenital acrochordon | 12.49 | 10.38 | 8 | 663024 | 49 | 55628986 |
Melanoma recurrent | 12.48 | 10.38 | 10 | 663022 | 91 | 55628944 |
Lip blister | 12.44 | 10.38 | 54 | 662978 | 2079 | 55626956 |
Hypoglycaemia neonatal | 12.40 | 10.38 | 31 | 663001 | 890 | 55628145 |
Thyroxine free abnormal | 12.38 | 10.38 | 6 | 663026 | 19 | 55629016 |
Retinal dystrophy | 12.38 | 10.38 | 6 | 663026 | 19 | 55629016 |
Oedema mouth | 12.36 | 10.38 | 57 | 662975 | 2253 | 55626782 |
Hyponatraemic seizure | 12.36 | 10.38 | 20 | 663012 | 415 | 55628620 |
Dental caries | 12.30 | 10.38 | 178 | 662854 | 9990 | 55619045 |
Vaccination site reaction | 12.30 | 10.38 | 11 | 663021 | 118 | 55628917 |
Pancreatic neoplasm | 12.29 | 10.38 | 27 | 663005 | 711 | 55628324 |
Tricuspid valve incompetence | 12.29 | 10.38 | 222 | 662810 | 13031 | 55616004 |
Drug withdrawal syndrome | 12.28 | 10.38 | 395 | 662637 | 25462 | 55603573 |
Varicose vein | 12.27 | 10.38 | 95 | 662937 | 4534 | 55624501 |
Metastases to bone | 12.24 | 10.38 | 159 | 662873 | 19349 | 55609686 |
Sodium retention | 12.22 | 10.38 | 11 | 663021 | 119 | 55628916 |
Lung lobectomy | 12.22 | 10.38 | 10 | 663022 | 94 | 55628941 |
Acute respiratory distress syndrome | 12.22 | 10.38 | 183 | 662849 | 21743 | 55607292 |
Alanine aminotransferase abnormal | 12.17 | 10.38 | 20 | 663012 | 4295 | 55624740 |
Lymph node palpable | 12.14 | 10.38 | 10 | 663022 | 95 | 55628940 |
Low density lipoprotein increased | 12.12 | 10.38 | 114 | 662918 | 5760 | 55623275 |
Vocal cord paresis | 12.08 | 10.38 | 11 | 663021 | 121 | 55628914 |
Mitral valve sclerosis | 12.08 | 10.38 | 11 | 663021 | 121 | 55628914 |
Intervertebral disc disorder | 12.06 | 10.38 | 93 | 662939 | 4433 | 55624602 |
Trance | 12.04 | 10.38 | 7 | 663025 | 35 | 55629000 |
Acetabulum fracture | 12.04 | 10.38 | 16 | 663016 | 276 | 55628759 |
Acute lymphocytic leukaemia recurrent | 12.02 | 10.38 | 6 | 663026 | 2291 | 55626744 |
Immune reconstitution inflammatory syndrome | 12.02 | 10.38 | 31 | 663001 | 5643 | 55623392 |
Bruxism | 12.01 | 10.38 | 71 | 662961 | 3095 | 55625940 |
Vein discolouration | 12.00 | 10.38 | 14 | 663018 | 210 | 55628825 |
Blindness | 12.00 | 10.38 | 293 | 662739 | 18128 | 55610907 |
Barrett's oesophagus | 11.99 | 10.38 | 24 | 663008 | 591 | 55628444 |
Bradykinesia | 11.99 | 10.38 | 98 | 662934 | 4756 | 55624279 |
Tonsillar disorder | 11.95 | 10.38 | 34 | 662998 | 1056 | 55627979 |
Large intestine polyp | 11.95 | 10.38 | 140 | 662892 | 7487 | 55621548 |
Immunodeficiency | 11.94 | 10.38 | 127 | 662905 | 16030 | 55613005 |
Foetal chromosome abnormality | 11.94 | 10.38 | 6 | 663026 | 21 | 55629014 |
Pancreatic disorder | 11.88 | 10.38 | 56 | 662976 | 2234 | 55626801 |
Drug reaction with eosinophilia and systemic symptoms | 11.86 | 10.38 | 269 | 662763 | 30035 | 55599000 |
Cough | 11.80 | 10.38 | 3334 | 659698 | 256627 | 55372408 |
Pulse abnormal | 11.78 | 10.38 | 50 | 662982 | 1906 | 55627129 |
Emotional disorder | 11.77 | 10.38 | 207 | 662825 | 12088 | 55616947 |
Electrocardiogram ST segment abnormal | 11.76 | 10.38 | 31 | 663001 | 920 | 55628115 |
Peripheral vascular disorder | 11.76 | 10.38 | 111 | 662921 | 5614 | 55623421 |
Haemorrhagic stroke | 11.72 | 10.38 | 106 | 662926 | 5297 | 55623738 |
Congenital hydronephrosis | 11.72 | 10.38 | 19 | 663013 | 395 | 55628640 |
Diabetic neuropathy | 11.71 | 10.38 | 80 | 662952 | 3668 | 55625367 |
Dactylitis | 11.67 | 10.38 | 5 | 663027 | 2087 | 55626948 |
Polymyalgia rheumatica | 11.62 | 10.38 | 69 | 662963 | 3013 | 55626022 |
Physical abuse | 11.61 | 10.38 | 4 | 663028 | 3 | 55629032 |
Neurologic neglect syndrome | 11.59 | 10.38 | 54 | 662978 | 2144 | 55626891 |
Acute hepatitis B | 11.58 | 10.38 | 17 | 663015 | 323 | 55628712 |
Immune-mediated hepatitis | 11.54 | 10.38 | 33 | 662999 | 1028 | 55628007 |
Cardiac valve sclerosis | 11.54 | 10.38 | 6 | 663026 | 23 | 55629012 |
Kidney malrotation | 11.54 | 10.38 | 6 | 663026 | 23 | 55629012 |
Neck pain | 11.53 | 10.38 | 858 | 662174 | 60697 | 55568338 |
Diplopia | 11.52 | 10.38 | 318 | 662714 | 20051 | 55608984 |
Intentional underdose | 11.49 | 10.38 | 45 | 662987 | 1653 | 55627382 |
Wheelchair user | 11.47 | 10.38 | 30 | 663002 | 5436 | 55623599 |
Viral mutation identified | 11.47 | 10.38 | 3 | 663029 | 1711 | 55627324 |
Mental status changes | 11.45 | 10.38 | 546 | 662486 | 36955 | 55592080 |
Follicular thyroid cancer | 11.43 | 10.38 | 8 | 663024 | 58 | 55628977 |
Presyncope | 11.43 | 10.38 | 388 | 662644 | 25194 | 55603841 |
Ulcer | 11.42 | 10.38 | 191 | 662841 | 22294 | 55606741 |
Vulvovaginal discomfort | 11.40 | 10.38 | 53 | 662979 | 2102 | 55626933 |
Mastication disorder | 11.38 | 10.38 | 49 | 662983 | 1880 | 55627155 |
Extrasystoles | 11.37 | 10.38 | 96 | 662936 | 4703 | 55624332 |
Urinary retention | 11.35 | 10.38 | 421 | 662611 | 27653 | 55601382 |
Tri-iodothyronine increased | 11.33 | 10.38 | 11 | 663021 | 132 | 55628903 |
Pure white cell aplasia | 11.31 | 10.38 | 7 | 663025 | 40 | 55628995 |
Pancreatic enzymes increased | 11.29 | 10.38 | 25 | 663007 | 662 | 55628373 |
Atrial flutter | 11.29 | 10.38 | 161 | 662871 | 9008 | 55620027 |
Weight loss poor | 11.27 | 10.38 | 33 | 662999 | 1042 | 55627993 |
Application site swelling | 11.26 | 10.38 | 22 | 663010 | 532 | 55628503 |
Pre-existing condition improved | 11.24 | 10.38 | 135 | 662897 | 7263 | 55621772 |
Drug ineffective for unapproved indication | 11.24 | 10.38 | 224 | 662808 | 25469 | 55603566 |
Pulmonary valve incompetence | 11.23 | 10.38 | 37 | 662995 | 1247 | 55627788 |
Supraventricular tachyarrhythmia | 11.22 | 10.38 | 9 | 663023 | 82 | 55628953 |
Blood potassium decreased | 11.17 | 10.38 | 560 | 662472 | 38112 | 55590923 |
Rotator cuff repair | 11.14 | 10.38 | 48 | 662984 | 1842 | 55627193 |
Euglycaemic diabetic ketoacidosis | 11.14 | 10.38 | 70 | 662962 | 3119 | 55625916 |
Psychomotor hyperactivity | 11.14 | 10.38 | 170 | 662862 | 9650 | 55619385 |
Microcephaly | 11.13 | 10.38 | 28 | 663004 | 807 | 55628228 |
Lacrimation increased | 11.11 | 10.38 | 289 | 662743 | 18059 | 55610976 |
Blood magnesium increased | 11.10 | 10.38 | 11 | 663021 | 2940 | 55626095 |
Injection site pruritus | 11.09 | 10.38 | 393 | 662639 | 41538 | 55587497 |
Metastases to liver | 11.08 | 10.38 | 183 | 662849 | 21403 | 55607632 |
Gastric pH increased | 11.05 | 10.38 | 7 | 663025 | 42 | 55628993 |
Histamine intolerance | 11.05 | 10.38 | 7 | 663025 | 42 | 55628993 |
Hypernatraemia | 11.04 | 10.38 | 123 | 662909 | 6497 | 55622538 |
Febrile bone marrow aplasia | 11.00 | 10.38 | 40 | 662992 | 6532 | 55622503 |
Meniere's disease | 11.00 | 10.38 | 13 | 663019 | 198 | 55628837 |
Deep brain stimulation | 10.98 | 10.38 | 6 | 663026 | 26 | 55629009 |
Panic attack | 10.95 | 10.38 | 317 | 662715 | 20130 | 55608905 |
Muscle tightness | 10.94 | 10.38 | 184 | 662848 | 10652 | 55618383 |
Stress fracture | 10.92 | 10.38 | 131 | 662901 | 7046 | 55621989 |
Rib fracture | 10.91 | 10.38 | 315 | 662717 | 19994 | 55609041 |
Respiratory disorder neonatal | 10.90 | 10.38 | 30 | 663002 | 914 | 55628121 |
Shock | 10.89 | 10.38 | 185 | 662847 | 21543 | 55607492 |
Complications of transplanted kidney | 10.87 | 10.38 | 7 | 663025 | 2322 | 55626713 |
Onychoclasis | 10.84 | 10.38 | 107 | 662925 | 5478 | 55623557 |
Growth hormone deficiency | 10.82 | 10.38 | 11 | 663021 | 140 | 55628895 |
Narrow anterior chamber angle | 10.79 | 10.38 | 7 | 663025 | 44 | 55628991 |
Radiotherapy | 10.79 | 10.38 | 16 | 663016 | 307 | 55628728 |
Tetany | 10.78 | 10.38 | 44 | 662988 | 1648 | 55627387 |
Ventricular extrasystoles | 10.76 | 10.38 | 184 | 662848 | 10686 | 55618349 |
Enamel anomaly | 10.76 | 10.38 | 5 | 663027 | 14 | 55629021 |
Polydipsia | 10.68 | 10.38 | 70 | 662962 | 3165 | 55625870 |
Vertigo positional | 10.65 | 10.38 | 60 | 662972 | 2569 | 55626466 |
Polyp | 10.65 | 10.38 | 112 | 662920 | 5830 | 55623205 |
Lumbosacral radiculopathy | 10.64 | 10.38 | 17 | 663015 | 349 | 55628686 |
Stasis dermatitis | 10.59 | 10.38 | 24 | 663008 | 646 | 55628389 |
Retroplacental haematoma | 10.58 | 10.38 | 11 | 663021 | 144 | 55628891 |
Kidney transplant rejection | 10.57 | 10.38 | 21 | 663011 | 4192 | 55624843 |
Product size issue | 10.56 | 10.38 | 16 | 663016 | 313 | 55628722 |
Joint stiffness | 10.56 | 10.38 | 327 | 662705 | 35098 | 55593937 |
Upper-airway cough syndrome | 10.55 | 10.38 | 163 | 662869 | 9275 | 55619760 |
Deformity | 10.53 | 10.38 | 74 | 662958 | 10181 | 55618854 |
Colorectal cancer | 10.53 | 10.38 | 15 | 663017 | 3414 | 55625621 |
Muscle contractions involuntary | 10.53 | 10.38 | 50 | 662982 | 2001 | 55627034 |
Chronic fatigue syndrome | 10.51 | 10.38 | 32 | 663000 | 1033 | 55628002 |
Oral neoplasm | 10.51 | 10.38 | 8 | 663024 | 67 | 55628968 |
Fracture nonunion | 10.51 | 10.38 | 53 | 662979 | 2174 | 55626861 |
Renal cyst | 10.50 | 10.38 | 161 | 662871 | 9148 | 55619887 |
Renal failure | 10.48 | 10.38 | 1470 | 661562 | 109030 | 55520005 |
Ocular discomfort | 10.48 | 10.38 | 78 | 662954 | 3677 | 55625358 |
IVth nerve paralysis | 10.48 | 10.38 | 6 | 663026 | 29 | 55629006 |
Senile osteoporosis | 10.46 | 10.38 | 13 | 663019 | 209 | 55628826 |
Phobia | 10.45 | 10.38 | 16 | 663016 | 316 | 55628719 |
Pleural neoplasm | 10.43 | 10.38 | 17 | 663015 | 355 | 55628680 |
Malignant neoplasm progression | 10.41 | 10.38 | 736 | 662296 | 72851 | 55556184 |
Throat lesion | 10.41 | 10.38 | 11 | 663021 | 147 | 55628888 |
Hallucination | 10.40 | 10.38 | 692 | 662340 | 48457 | 55580578 |
Acute myeloid leukaemia | 10.40 | 10.38 | 139 | 662893 | 16833 | 55612202 |
Mental impairment | 10.39 | 10.38 | 209 | 662823 | 12513 | 55616522 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypothyroidism | 652.93 | 10.54 | 649 | 180110 | 17298 | 31499287 |
Blood thyroid stimulating hormone increased | 302.28 | 10.54 | 210 | 180549 | 3327 | 31513258 |
Drug abuse | 265.24 | 10.54 | 85 | 180674 | 87673 | 31428912 |
Foetal exposure during pregnancy | 208.38 | 10.54 | 608 | 180151 | 40268 | 31476317 |
Drug ineffective | 198.30 | 10.54 | 1383 | 179376 | 394190 | 31122395 |
Toxicity to various agents | 180.91 | 10.54 | 488 | 180271 | 180999 | 31335586 |
Atrial septal defect | 172.14 | 10.54 | 205 | 180554 | 6722 | 31509863 |
Off label use | 159.02 | 10.54 | 1245 | 179514 | 346029 | 31170556 |
Febrile neutropenia | 126.35 | 10.54 | 321 | 180438 | 121528 | 31395057 |
Craniopharyngioma | 124.35 | 10.54 | 51 | 180708 | 246 | 31516339 |
Fatigue | 108.00 | 10.54 | 2585 | 178174 | 332621 | 31183964 |
Small for dates baby | 105.71 | 10.54 | 117 | 180642 | 3538 | 31513047 |
Blood thyroid stimulating hormone decreased | 101.61 | 10.54 | 85 | 180674 | 1798 | 31514787 |
Thyroid disorder | 99.52 | 10.54 | 103 | 180656 | 2880 | 31513705 |
Asthenia | 88.32 | 10.54 | 1784 | 178975 | 222971 | 31293614 |
Treatment failure | 83.56 | 10.54 | 66 | 180693 | 40726 | 31475859 |
Thyroid function test abnormal | 82.79 | 10.54 | 51 | 180708 | 651 | 31515934 |
Blood thyroid stimulating hormone abnormal | 72.93 | 10.54 | 37 | 180722 | 314 | 31516271 |
Pituitary tumour benign | 72.56 | 10.54 | 50 | 180709 | 781 | 31515804 |
Neutropenia | 67.32 | 10.54 | 496 | 180263 | 139868 | 31376717 |
Drug resistance | 66.85 | 10.54 | 25 | 180734 | 23428 | 31493157 |
Drug dependence | 62.81 | 10.54 | 25 | 180734 | 22554 | 31494031 |
Insulin-like growth factor decreased | 57.58 | 10.54 | 29 | 180730 | 242 | 31516343 |
Thyroxine free decreased | 56.29 | 10.54 | 29 | 180730 | 255 | 31516330 |
Large for dates baby | 56.11 | 10.54 | 44 | 180715 | 846 | 31515739 |
Respiratory disorder neonatal | 56.07 | 10.54 | 55 | 180704 | 1440 | 31515145 |
Product use in unapproved indication | 52.68 | 10.54 | 340 | 180419 | 98831 | 31417754 |
Hypopituitarism | 52.67 | 10.54 | 61 | 180698 | 1940 | 31514645 |
Insulin-like growth factor increased | 50.92 | 10.54 | 47 | 180712 | 1138 | 31515447 |
Thyroid cancer | 50.42 | 10.54 | 54 | 180705 | 1572 | 31515013 |
Patent ductus arteriosus | 49.39 | 10.54 | 75 | 180684 | 3118 | 31513467 |
Autoimmune thyroiditis | 47.82 | 10.54 | 44 | 180715 | 1061 | 31515524 |
Hyperthyroidism | 46.88 | 10.54 | 141 | 180618 | 9490 | 31507095 |
Chronic pigmented purpura | 45.46 | 10.54 | 19 | 180740 | 97 | 31516488 |
Infantile apnoea | 43.98 | 10.54 | 39 | 180720 | 895 | 31515690 |
Decreased appetite | 43.85 | 10.54 | 1164 | 179595 | 152053 | 31364532 |
Adrenocortical insufficiency acute | 43.76 | 10.54 | 46 | 180713 | 1310 | 31515275 |
Bradycardia neonatal | 43.40 | 10.54 | 39 | 180720 | 911 | 31515674 |
Dizziness | 42.23 | 10.54 | 1458 | 179301 | 197689 | 31318896 |
Thyroxine decreased | 42.02 | 10.54 | 19 | 180740 | 121 | 31516464 |
Fall | 41.38 | 10.54 | 1370 | 179389 | 184719 | 31331866 |
Cytomegalovirus infection | 40.17 | 10.54 | 49 | 180710 | 24658 | 31491927 |
Pyloric stenosis | 40.06 | 10.54 | 34 | 180725 | 734 | 31515851 |
Neurotoxicity | 38.94 | 10.54 | 22 | 180737 | 16204 | 31500381 |
Ventricular septal defect | 36.57 | 10.54 | 71 | 180688 | 3606 | 31512979 |
Bone marrow failure | 36.31 | 10.54 | 65 | 180694 | 27943 | 31488642 |
Rheumatoid arthritis | 36.13 | 10.54 | 145 | 180614 | 47664 | 31468921 |
Intentional product misuse | 35.51 | 10.54 | 105 | 180654 | 37846 | 31478739 |
Goitre | 35.26 | 10.54 | 44 | 180715 | 1515 | 31515070 |
Suicide attempt | 34.89 | 10.54 | 103 | 180656 | 37145 | 31479440 |
Thyroid hormones decreased | 34.25 | 10.54 | 17 | 180742 | 137 | 31516448 |
Epiphysiolysis | 33.91 | 10.54 | 15 | 180744 | 90 | 31516495 |
Tropical infectious disease | 33.64 | 10.54 | 12 | 180747 | 36 | 31516549 |
Pituitary tumour recurrent | 33.05 | 10.54 | 13 | 180746 | 55 | 31516530 |
Sepsis | 32.40 | 10.54 | 641 | 180118 | 151288 | 31365297 |
Multiple organ dysfunction syndrome | 32.17 | 10.54 | 242 | 180517 | 67961 | 31448624 |
Hypophysitis | 31.98 | 10.54 | 49 | 180710 | 2053 | 31514532 |
Graft versus host disease | 31.74 | 10.54 | 10 | 180749 | 10437 | 31506148 |
Secondary hypogonadism | 31.32 | 10.54 | 20 | 180739 | 273 | 31516312 |
Immune reconstitution inflammatory syndrome | 30.48 | 10.54 | 5 | 180754 | 8173 | 31508412 |
Synovitis | 30.43 | 10.54 | 16 | 180743 | 12267 | 31504318 |
Diarrhoea | 29.90 | 10.54 | 2364 | 178395 | 350045 | 31166540 |
Pneumocystis jirovecii pneumonia | 29.87 | 10.54 | 36 | 180723 | 18215 | 31498370 |
Adrenal insufficiency | 29.74 | 10.54 | 147 | 180612 | 12512 | 31504073 |
Dysphonia | 29.53 | 10.54 | 210 | 180549 | 20381 | 31496204 |
Toxic epidermal necrolysis | 29.39 | 10.54 | 41 | 180718 | 19483 | 31497102 |
Overdose | 29.25 | 10.54 | 325 | 180434 | 84339 | 31432246 |
Infusion related reaction | 28.52 | 10.54 | 159 | 180600 | 47896 | 31468689 |
Blood testosterone decreased | 28.24 | 10.54 | 70 | 180689 | 4203 | 31512382 |
Drug hypersensitivity | 28.22 | 10.54 | 271 | 180488 | 72328 | 31444257 |
Bronchopulmonary aspergillosis | 27.99 | 10.54 | 22 | 180737 | 13612 | 31502973 |
Therapeutic product effect incomplete | 27.93 | 10.54 | 141 | 180618 | 43555 | 31473030 |
Dehydration | 27.75 | 10.54 | 882 | 179877 | 118229 | 31398356 |
Potassium wasting nephropathy | 27.61 | 10.54 | 13 | 180746 | 92 | 31516493 |
Substance abuse | 27.53 | 10.54 | 4 | 180755 | 7154 | 31509431 |
Pyrexia | 27.43 | 10.54 | 1435 | 179324 | 302405 | 31214180 |
Haematotoxicity | 27.42 | 10.54 | 4 | 180755 | 7133 | 31509452 |
Leukopenia | 27.36 | 10.54 | 205 | 180554 | 57623 | 31458962 |
Neonatal behavioural syndrome | 27.28 | 10.54 | 14 | 180745 | 122 | 31516463 |
Pathogen resistance | 27.02 | 10.54 | 8 | 180751 | 8693 | 31507892 |
Macrocephaly | 26.59 | 10.54 | 22 | 180737 | 458 | 31516127 |
Palmar-plantar erythrodysaesthesia syndrome | 26.48 | 10.54 | 165 | 180594 | 15318 | 31501267 |
Diabetes insipidus | 26.44 | 10.54 | 50 | 180709 | 2490 | 31514095 |
Drug ineffective for unapproved indication | 26.15 | 10.54 | 38 | 180721 | 17752 | 31498833 |
Thyroxine free increased | 26.13 | 10.54 | 17 | 180742 | 240 | 31516345 |
Walking aid user | 26.12 | 10.54 | 39 | 180720 | 1597 | 31514988 |
Diabetic foetopathy | 26.06 | 10.54 | 16 | 180743 | 203 | 31516382 |
Hypospadias | 26.05 | 10.54 | 56 | 180703 | 3060 | 31513525 |
Aspergillus infection | 25.75 | 10.54 | 17 | 180742 | 11511 | 31505074 |
Cytomegalovirus viraemia | 25.31 | 10.54 | 4 | 180755 | 6721 | 31509864 |
Flatulence | 25.31 | 10.54 | 190 | 180569 | 18758 | 31497827 |
Poisoning | 25.06 | 10.54 | 14 | 180745 | 10377 | 31506208 |
Blood thyroid stimulating hormone normal | 25.04 | 10.54 | 6 | 180753 | 0 | 31516585 |
Neoplasm recurrence | 25.02 | 10.54 | 44 | 180715 | 2070 | 31514515 |
Papillary thyroid cancer | 24.98 | 10.54 | 24 | 180735 | 612 | 31515973 |
Electrocardiogram QRS complex abnormal | 24.73 | 10.54 | 18 | 180741 | 308 | 31516277 |
Myxoedema coma | 24.70 | 10.54 | 17 | 180742 | 265 | 31516320 |
Premature baby | 24.61 | 10.54 | 182 | 180577 | 17884 | 31498701 |
General physical health deterioration | 24.37 | 10.54 | 832 | 179927 | 112603 | 31403982 |
Pulmonary valve stenosis congenital | 24.16 | 10.54 | 13 | 180746 | 126 | 31516459 |
Weight decreased | 24.08 | 10.54 | 1129 | 179630 | 158823 | 31357762 |
Newborn persistent pulmonary hypertension | 23.64 | 10.54 | 12 | 180747 | 102 | 31516483 |
Septic shock | 23.63 | 10.54 | 252 | 180507 | 65906 | 31450679 |
Congenital mitral valve incompetence | 23.34 | 10.54 | 12 | 180747 | 105 | 31516480 |
Anti-thyroid antibody positive | 23.32 | 10.54 | 10 | 180749 | 55 | 31516530 |
Thyroiditis | 23.32 | 10.54 | 43 | 180716 | 2100 | 31514485 |
Selective eating disorder | 23.28 | 10.54 | 38 | 180721 | 1682 | 31514903 |
Cerebral atrophy congenital | 22.89 | 10.54 | 10 | 180749 | 58 | 31516527 |
Painful respiration | 22.84 | 10.54 | 31 | 180728 | 1161 | 31515424 |
C-reactive protein increased | 22.76 | 10.54 | 173 | 180586 | 48477 | 31468108 |
Glossodynia | 22.52 | 10.54 | 56 | 180703 | 3369 | 31513216 |
Growth hormone deficiency | 22.42 | 10.54 | 16 | 180743 | 265 | 31516320 |
Tri-iodothyronine decreased | 22.35 | 10.54 | 9 | 180750 | 41 | 31516544 |
Contraindicated product administered | 22.11 | 10.54 | 50 | 180709 | 19722 | 31496863 |
Neutropenic sepsis | 21.81 | 10.54 | 23 | 180736 | 12356 | 31504229 |
Thyroid hormones increased | 21.57 | 10.54 | 10 | 180749 | 68 | 31516517 |
Granulocytopenia | 21.42 | 10.54 | 80 | 180679 | 6019 | 31510566 |
Sedation | 21.17 | 10.54 | 48 | 180711 | 18917 | 31497668 |
Intentional self-injury | 21.02 | 10.54 | 27 | 180732 | 13288 | 31503297 |
Hypoglycaemia neonatal | 20.98 | 10.54 | 37 | 180722 | 1745 | 31514840 |
Post procedural hypothyroidism | 20.91 | 10.54 | 6 | 180753 | 6 | 31516579 |
Blood thyroid stimulating hormone | 20.86 | 10.54 | 5 | 180754 | 0 | 31516585 |
Epstein-Barr virus infection | 20.51 | 10.54 | 7 | 180752 | 6946 | 31509639 |
Aortic aneurysm | 20.42 | 10.54 | 82 | 180677 | 6383 | 31510202 |
Coeliac disease | 20.41 | 10.54 | 21 | 180738 | 583 | 31516002 |
Hypoacusis | 20.37 | 10.54 | 151 | 180608 | 14848 | 31501737 |
Pituitary apoplexy | 20.31 | 10.54 | 8 | 180751 | 34 | 31516551 |
Cerebrovascular accident | 20.21 | 10.54 | 595 | 180164 | 78889 | 31437696 |
Therapy non-responder | 19.99 | 10.54 | 112 | 180647 | 33699 | 31482886 |
Neonatal respiratory distress syndrome | 19.98 | 10.54 | 58 | 180701 | 3827 | 31512758 |
Product use issue | 19.94 | 10.54 | 217 | 180542 | 56542 | 31460043 |
Haemangioma congenital | 19.92 | 10.54 | 19 | 180740 | 480 | 31516105 |
Growth retardation | 19.90 | 10.54 | 35 | 180724 | 1647 | 31514938 |
Tumour lysis syndrome | 19.67 | 10.54 | 36 | 180723 | 15349 | 31501236 |
Fractured coccyx | 19.56 | 10.54 | 12 | 180747 | 152 | 31516433 |
Hepatic function abnormal | 19.56 | 10.54 | 146 | 180613 | 41076 | 31475509 |
Transplant rejection | 19.51 | 10.54 | 16 | 180743 | 9692 | 31506893 |
Drug intolerance | 19.47 | 10.54 | 196 | 180563 | 51837 | 31464748 |
Dermatomyositis | 19.45 | 10.54 | 29 | 180730 | 1186 | 31515399 |
Completed suicide | 19.21 | 10.54 | 387 | 180372 | 91127 | 31425458 |
Dry skin | 19.15 | 10.54 | 226 | 180533 | 25255 | 31491330 |
Thyroid cancer metastatic | 19.12 | 10.54 | 8 | 180751 | 41 | 31516544 |
Ankylosing spondylitis | 19.02 | 10.54 | 5 | 180754 | 5876 | 31510709 |
Neonatal tachypnoea | 18.97 | 10.54 | 12 | 180747 | 161 | 31516424 |
Anencephaly | 18.73 | 10.54 | 11 | 180748 | 128 | 31516457 |
Respiratory depression | 18.51 | 10.54 | 34 | 180725 | 14476 | 31502109 |
Wrong schedule | 18.47 | 10.54 | 12 | 180747 | 169 | 31516416 |
Hyponatraemia | 18.37 | 10.54 | 551 | 180208 | 73248 | 31443337 |
Infective pulmonary exacerbation of cystic fibrosis | 18.33 | 10.54 | 7 | 180752 | 6477 | 31510108 |
Febrile bone marrow aplasia | 18.31 | 10.54 | 11 | 180748 | 7835 | 31508750 |
Pituitary tumour | 18.22 | 10.54 | 19 | 180740 | 536 | 31516049 |
Myelosuppression | 18.13 | 10.54 | 36 | 180723 | 14884 | 31501701 |
Haemophagocytic lymphohistiocytosis | 18.11 | 10.54 | 24 | 180735 | 11654 | 31504931 |
Intentional overdose | 18.05 | 10.54 | 150 | 180609 | 41239 | 31475346 |
Drug reaction with eosinophilia and systemic symptoms | 17.98 | 10.54 | 99 | 180660 | 29919 | 31486666 |
Cortisol decreased | 17.95 | 10.54 | 25 | 180734 | 960 | 31515625 |
Conduction disorder | 17.88 | 10.54 | 36 | 180723 | 1878 | 31514707 |
Rhythm idioventricular | 17.73 | 10.54 | 14 | 180745 | 272 | 31516313 |
Blood growth hormone increased | 17.71 | 10.54 | 15 | 180744 | 323 | 31516262 |
Neutrophil count decreased | 17.68 | 10.54 | 174 | 180585 | 46220 | 31470365 |
Alanine aminotransferase increased | 17.11 | 10.54 | 311 | 180448 | 74345 | 31442240 |
Neonatal respiratory acidosis | 16.95 | 10.54 | 8 | 180751 | 57 | 31516528 |
Dependence on oxygen therapy | 16.75 | 10.54 | 12 | 180747 | 200 | 31516385 |
Thyroid cancer recurrent | 16.69 | 10.54 | 4 | 180755 | 0 | 31516585 |
Interstitial lung disease | 16.64 | 10.54 | 248 | 180511 | 61155 | 31455430 |
Metastatic renal cell carcinoma | 16.49 | 10.54 | 41 | 180718 | 2466 | 31514119 |
Tri-iodothyronine increased | 16.38 | 10.54 | 8 | 180751 | 62 | 31516523 |
Anaphylactic reaction | 16.35 | 10.54 | 100 | 180659 | 29453 | 31487132 |
Tachyarrhythmia | 16.31 | 10.54 | 48 | 180711 | 3191 | 31513394 |
Intercapillary glomerulosclerosis | 16.25 | 10.54 | 7 | 180752 | 39 | 31516546 |
Brain natriuretic peptide abnormal | 16.24 | 10.54 | 14 | 180745 | 309 | 31516276 |
Pseudomonas infection | 16.13 | 10.54 | 25 | 180734 | 11376 | 31505209 |
Alveolitis | 16.11 | 10.54 | 31 | 180728 | 1564 | 31515021 |
Total lung capacity abnormal | 16.08 | 10.54 | 10 | 180749 | 130 | 31516455 |
Acute graft versus host disease in skin | 15.84 | 10.54 | 4 | 180755 | 4828 | 31511757 |
Colorectal cancer | 15.82 | 10.54 | 4 | 180755 | 4825 | 31511760 |
Mucormycosis | 15.77 | 10.54 | 6 | 180753 | 5564 | 31511021 |
Cytopenia | 15.71 | 10.54 | 24 | 180735 | 10986 | 31505599 |
Anaphylactic shock | 15.63 | 10.54 | 36 | 180723 | 14109 | 31502476 |
Constipation | 15.52 | 10.54 | 860 | 179899 | 123131 | 31393454 |
Coagulation disorder neonatal | 15.52 | 10.54 | 6 | 180753 | 24 | 31516561 |
Adenovirus infection | 15.46 | 10.54 | 4 | 180755 | 4750 | 31511835 |
C-reactive protein abnormal | 15.37 | 10.54 | 13 | 180746 | 7756 | 31508829 |
Mucosal inflammation | 15.36 | 10.54 | 124 | 180635 | 34303 | 31482282 |
Pulmonary artery stenosis | 15.25 | 10.54 | 12 | 180747 | 232 | 31516353 |
Enthesopathy | 15.16 | 10.54 | 3 | 180756 | 4284 | 31512301 |
Neonatal respiratory distress | 15.15 | 10.54 | 17 | 180742 | 522 | 31516063 |
Urine oxalate increased | 15.11 | 10.54 | 5 | 180754 | 11 | 31516574 |
Delirium | 15.10 | 10.54 | 157 | 180602 | 41264 | 31475321 |
Hyperprolactinaemia | 15.08 | 10.54 | 29 | 180730 | 1462 | 31515123 |
Exposure via breast milk | 15.06 | 10.54 | 33 | 180726 | 1827 | 31514758 |
Nephropathy toxic | 15.03 | 10.54 | 26 | 180733 | 11327 | 31505258 |
Tongue movement disturbance | 15.00 | 10.54 | 8 | 180751 | 76 | 31516509 |
Foreign body in throat | 15.00 | 10.54 | 8 | 180751 | 76 | 31516509 |
N-terminal prohormone brain natriuretic peptide abnormal | 14.88 | 10.54 | 11 | 180748 | 193 | 31516392 |
Diffuse alopecia | 14.81 | 10.54 | 5 | 180754 | 12 | 31516573 |
Sopor | 14.80 | 10.54 | 27 | 180732 | 11525 | 31505060 |
Pulmonary arterial pressure abnormal | 14.78 | 10.54 | 11 | 180748 | 195 | 31516390 |
Colitis ulcerative | 14.76 | 10.54 | 55 | 180704 | 18474 | 31498111 |
Thyroidectomy | 14.70 | 10.54 | 7 | 180752 | 51 | 31516534 |
Product prescribing error | 14.66 | 10.54 | 174 | 180585 | 19468 | 31497117 |
Blood glucose increased | 14.65 | 10.54 | 454 | 180305 | 60629 | 31455956 |
Bronchiectasis | 14.61 | 10.54 | 13 | 180746 | 7567 | 31509018 |
Atrial fibrillation | 14.60 | 10.54 | 791 | 179968 | 112992 | 31403593 |
Epispadias | 14.58 | 10.54 | 10 | 180749 | 155 | 31516430 |
Hypersomnia | 14.57 | 10.54 | 111 | 180648 | 11008 | 31505577 |
Thyroxine increased | 14.49 | 10.54 | 8 | 180751 | 82 | 31516503 |
Hepatotoxicity | 14.45 | 10.54 | 58 | 180701 | 19068 | 31497517 |
Forced vital capacity decreased | 14.34 | 10.54 | 19 | 180740 | 695 | 31515890 |
Shoulder dystocia | 14.30 | 10.54 | 6 | 180753 | 31 | 31516554 |
Therapy partial responder | 14.23 | 10.54 | 10 | 180749 | 6552 | 31510033 |
Anaemia of malignant disease | 14.02 | 10.54 | 15 | 180744 | 436 | 31516149 |
Prescribed underdose | 14.02 | 10.54 | 88 | 180671 | 8190 | 31508395 |
Chest injury | 13.99 | 10.54 | 28 | 180731 | 1454 | 31515131 |
Tracheal fistula | 13.93 | 10.54 | 8 | 180751 | 89 | 31516496 |
Muscular weakness | 13.78 | 10.54 | 479 | 180280 | 64969 | 31451616 |
BK virus infection | 13.59 | 10.54 | 6 | 180753 | 5089 | 31511496 |
Condition aggravated | 13.56 | 10.54 | 781 | 179978 | 163228 | 31353357 |
Aorticopulmonary septal defect | 13.55 | 10.54 | 5 | 180754 | 17 | 31516568 |
Lymphocyte count decreased | 13.55 | 10.54 | 66 | 180693 | 20583 | 31496002 |
Serotonin syndrome | 13.51 | 10.54 | 58 | 180701 | 18715 | 31497870 |
Lumbar puncture | 13.48 | 10.54 | 8 | 180751 | 95 | 31516490 |
Mineral deficiency | 13.43 | 10.54 | 6 | 180753 | 37 | 31516548 |
Urticaria | 13.37 | 10.54 | 239 | 180520 | 57278 | 31459307 |
Osteochondroma | 13.34 | 10.54 | 5 | 180754 | 18 | 31516567 |
Oxygen saturation increased | 13.30 | 10.54 | 12 | 180747 | 282 | 31516303 |
Ageusia | 13.28 | 10.54 | 95 | 180664 | 9236 | 31507349 |
Drug interaction | 13.21 | 10.54 | 1017 | 179742 | 207526 | 31309059 |
Aplastic anaemia | 13.19 | 10.54 | 20 | 180739 | 9183 | 31507402 |
Maternal exposure during breast feeding | 13.14 | 10.54 | 28 | 180731 | 1521 | 31515064 |
Brain oedema | 13.12 | 10.54 | 34 | 180725 | 12798 | 31503787 |
Medulloblastoma recurrent | 13.08 | 10.54 | 7 | 180752 | 67 | 31516518 |
Appendicitis | 12.81 | 10.54 | 29 | 180730 | 11436 | 31505149 |
Follicular thyroid cancer | 12.68 | 10.54 | 4 | 180755 | 7 | 31516578 |
Hypotonia neonatal | 12.68 | 10.54 | 25 | 180734 | 1284 | 31515301 |
Acute myeloid leukaemia | 12.65 | 10.54 | 59 | 180700 | 18613 | 31497972 |
Tricuspid valve incompetence | 12.63 | 10.54 | 90 | 180669 | 8739 | 31507846 |
Tracheal pain | 12.57 | 10.54 | 6 | 180753 | 44 | 31516541 |
Empty sella syndrome | 12.57 | 10.54 | 6 | 180753 | 44 | 31516541 |
Polyglandular autoimmune syndrome type II | 12.52 | 10.54 | 3 | 180756 | 0 | 31516585 |
Primary hypothyroidism | 12.45 | 10.54 | 6 | 180753 | 45 | 31516540 |
Blood glucose decreased | 12.37 | 10.54 | 117 | 180642 | 12354 | 31504231 |
Thyroid operation | 12.34 | 10.54 | 4 | 180755 | 8 | 31516577 |
Neonatal pneumothorax | 12.34 | 10.54 | 4 | 180755 | 8 | 31516577 |
Neutrophil count increased | 12.33 | 10.54 | 47 | 180712 | 15684 | 31500901 |
Cardiogenic shock | 12.30 | 10.54 | 76 | 180683 | 22332 | 31494253 |
Product substitution issue | 12.27 | 10.54 | 94 | 180665 | 9338 | 31507247 |
Oedema peripheral | 12.25 | 10.54 | 754 | 180005 | 109085 | 31407500 |
Cytokine release syndrome | 12.24 | 10.54 | 51 | 180708 | 16591 | 31499994 |
Chest discomfort | 12.16 | 10.54 | 203 | 180556 | 49166 | 31467419 |
Application site erythema | 12.14 | 10.54 | 33 | 180726 | 2096 | 31514489 |
Hypernatraemia | 12.08 | 10.54 | 80 | 180679 | 7583 | 31509002 |
Retrograde amnesia | 12.06 | 10.54 | 8 | 180751 | 117 | 31516468 |
Seroma | 12.00 | 10.54 | 16 | 180743 | 589 | 31515996 |
Disorientation | 11.99 | 10.54 | 244 | 180515 | 30500 | 31486085 |
Cranial sutures widening | 11.95 | 10.54 | 7 | 180752 | 81 | 31516504 |
Hypertension | 11.90 | 10.54 | 866 | 179893 | 127234 | 31389351 |
Intentional product use issue | 11.80 | 10.54 | 204 | 180555 | 49143 | 31467442 |
Cardiotoxicity | 11.80 | 10.54 | 7 | 180752 | 5020 | 31511565 |
Tri-iodothyronine free increased | 11.74 | 10.54 | 4 | 180755 | 10 | 31516575 |
Urethral valves | 11.73 | 10.54 | 11 | 180748 | 272 | 31516313 |
Pancytopenia | 11.72 | 10.54 | 394 | 180365 | 86922 | 31429663 |
Hypersensitivity | 11.61 | 10.54 | 236 | 180523 | 55507 | 31461078 |
Neonatal asphyxia | 11.58 | 10.54 | 12 | 180747 | 336 | 31516249 |
Cytomegalovirus infection reactivation | 11.52 | 10.54 | 4 | 180755 | 3925 | 31512660 |
Myoclonic dystonia | 11.47 | 10.54 | 4 | 180755 | 11 | 31516574 |
Thyroxine abnormal | 11.47 | 10.54 | 4 | 180755 | 11 | 31516574 |
Therapeutic product effect decreased | 11.46 | 10.54 | 120 | 180639 | 31502 | 31485083 |
Liposarcoma | 11.45 | 10.54 | 8 | 180751 | 128 | 31516457 |
Extrapyramidal disorder | 11.44 | 10.54 | 32 | 180727 | 11746 | 31504839 |
Bradycardia | 11.42 | 10.54 | 494 | 180265 | 68833 | 31447752 |
Infection | 11.40 | 10.54 | 368 | 180391 | 81563 | 31435022 |
Neonatal respiratory failure | 11.35 | 10.54 | 12 | 180747 | 344 | 31516241 |
Syncope | 11.28 | 10.54 | 594 | 180165 | 84588 | 31431997 |
Congenital hydronephrosis | 11.28 | 10.54 | 17 | 180742 | 702 | 31515883 |
Skin indentation | 11.21 | 10.54 | 4 | 180755 | 12 | 31516573 |
Thrombocytopenia | 11.21 | 10.54 | 683 | 180076 | 142064 | 31374521 |
Gastrooesophageal cancer | 11.17 | 10.54 | 5 | 180754 | 31 | 31516554 |
Growth hormone-producing pituitary tumour | 10.91 | 10.54 | 6 | 180753 | 61 | 31516524 |
Toxic neuropathy | 10.89 | 10.54 | 14 | 180745 | 497 | 31516088 |
Agitation neonatal | 10.88 | 10.54 | 21 | 180738 | 1062 | 31515523 |
Hyperbilirubinaemia neonatal | 10.87 | 10.54 | 17 | 180742 | 725 | 31515860 |
Thyroid mass | 10.82 | 10.54 | 13 | 180746 | 430 | 31516155 |
Artery dissection | 10.81 | 10.54 | 7 | 180752 | 98 | 31516487 |
Blood prolactin decreased | 10.80 | 10.54 | 10 | 180749 | 243 | 31516342 |
Hyperparathyroidism | 10.79 | 10.54 | 22 | 180737 | 1158 | 31515427 |
Scapula fracture | 10.77 | 10.54 | 10 | 180749 | 244 | 31516341 |
Performance enhancing product use | 10.75 | 10.54 | 7 | 180752 | 99 | 31516486 |
Haemorrhoids | 10.75 | 10.54 | 113 | 180646 | 12269 | 31504316 |
Gait inability | 10.73 | 10.54 | 161 | 180598 | 18983 | 31497602 |
Gangrene neonatal | 10.69 | 10.54 | 9 | 180750 | 192 | 31516393 |
Brachydactyly | 10.69 | 10.54 | 9 | 180750 | 192 | 31516393 |
Oral discomfort | 10.69 | 10.54 | 35 | 180724 | 2465 | 31514120 |
Application site inflammation | 10.69 | 10.54 | 7 | 180752 | 100 | 31516485 |
Bronchopneumopathy | 10.66 | 10.54 | 13 | 180746 | 437 | 31516148 |
Moaning | 10.62 | 10.54 | 17 | 180742 | 740 | 31515845 |
Cholelithiasis | 10.60 | 10.54 | 163 | 180596 | 19316 | 31497269 |
Cervicogenic headache | 10.54 | 10.54 | 4 | 180755 | 15 | 31516570 |
Incarcerated umbilical hernia | 10.54 | 10.54 | 4 | 180755 | 15 | 31516570 |
Hospice care | 10.54 | 10.54 | 61 | 180698 | 5515 | 31511070 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypothyroidism | 1339.60 | 10.29 | 1898 | 670200 | 43857 | 70212489 |
Blood thyroid stimulating hormone increased | 787.42 | 10.29 | 649 | 671449 | 7830 | 70248516 |
Drug ineffective | 628.02 | 10.29 | 5794 | 666304 | 933958 | 69322388 |
Pemphigus | 531.24 | 10.29 | 77 | 672021 | 82959 | 70173387 |
Off label use | 455.29 | 10.29 | 4676 | 667422 | 738384 | 69517962 |
Drug abuse | 448.22 | 10.29 | 440 | 671658 | 146816 | 70109530 |
Synovitis | 438.02 | 10.29 | 349 | 671749 | 128879 | 70127467 |
Rheumatoid arthritis | 437.96 | 10.29 | 1365 | 670733 | 290440 | 69965906 |
Anti-cyclic citrullinated peptide antibody positive | 431.03 | 10.29 | 73 | 672025 | 70112 | 70186234 |
Toxicity to various agents | 429.98 | 10.29 | 2010 | 670088 | 380162 | 69876184 |
Treatment failure | 399.34 | 10.29 | 466 | 671632 | 143676 | 70112670 |
Contraindicated product administered | 387.30 | 10.29 | 422 | 671676 | 134190 | 70122156 |
Systemic lupus erythematosus | 384.97 | 10.29 | 245 | 671853 | 101657 | 70154689 |
Hand deformity | 362.43 | 10.29 | 183 | 671915 | 86299 | 70170047 |
Drug intolerance | 351.88 | 10.29 | 1037 | 671061 | 224650 | 70031696 |
Fall | 350.14 | 10.29 | 6031 | 666067 | 438065 | 69818281 |
Infusion related reaction | 344.49 | 10.29 | 859 | 671239 | 196675 | 70059671 |
Pericarditis | 342.05 | 10.29 | 188 | 671910 | 84517 | 70171829 |
Febrile neutropenia | 333.81 | 10.29 | 918 | 671180 | 203400 | 70052946 |
Glossodynia | 322.50 | 10.29 | 211 | 671887 | 86276 | 70170070 |
Duodenal ulcer perforation | 279.05 | 10.29 | 70 | 672028 | 51042 | 70205304 |
Blood thyroid stimulating hormone decreased | 277.58 | 10.29 | 299 | 671799 | 5155 | 70251191 |
Rheumatoid factor positive | 246.12 | 10.29 | 76 | 672022 | 48324 | 70208022 |
Hyperthyroidism | 241.19 | 10.29 | 566 | 671532 | 19525 | 70236821 |
Completed suicide | 239.79 | 10.29 | 1221 | 670877 | 225914 | 70030432 |
Arthropathy | 238.49 | 10.29 | 683 | 671415 | 149374 | 70106972 |
Therapeutic product effect decreased | 232.44 | 10.29 | 644 | 671454 | 142374 | 70113972 |
Blood thyroid stimulating hormone normal | 229.03 | 10.29 | 73 | 672025 | 52 | 70256294 |
Folliculitis | 223.49 | 10.29 | 63 | 672035 | 42507 | 70213839 |
Thyroid disorder | 217.34 | 10.29 | 416 | 671682 | 12416 | 70243930 |
Asthenia | 216.19 | 10.29 | 5771 | 666327 | 451895 | 69804451 |
Muscle injury | 213.49 | 10.29 | 51 | 672047 | 38443 | 70217903 |
Drug resistance | 212.99 | 10.29 | 50 | 672048 | 38140 | 70218206 |
Helicobacter infection | 209.91 | 10.29 | 134 | 671964 | 55522 | 70200824 |
Drug hypersensitivity | 209.55 | 10.29 | 1540 | 670558 | 260919 | 69995427 |
Palpitations | 189.07 | 10.29 | 1739 | 670359 | 109014 | 70147332 |
Wound | 186.69 | 10.29 | 411 | 671687 | 98321 | 70158025 |
Dizziness | 185.00 | 10.29 | 5729 | 666369 | 458412 | 69797934 |
Sleep disorder due to general medical condition, insomnia type | 181.88 | 10.29 | 56 | 672042 | 35676 | 70220670 |
Product use in unapproved indication | 181.03 | 10.29 | 1186 | 670912 | 206292 | 70050054 |
Blood thyroid stimulating hormone abnormal | 181.02 | 10.29 | 109 | 671989 | 758 | 70255588 |
Thyroid function test abnormal | 180.81 | 10.29 | 180 | 671918 | 2817 | 70253529 |
Hepatic enzyme increased | 174.79 | 10.29 | 828 | 671270 | 156162 | 70100184 |
Lower respiratory tract infection | 173.70 | 10.29 | 515 | 671583 | 111398 | 70144948 |
Discomfort | 155.94 | 10.29 | 496 | 671602 | 104940 | 70151406 |
Hypersensitivity | 149.61 | 10.29 | 1423 | 670675 | 228389 | 70027957 |
Hyponatraemia | 148.88 | 10.29 | 2236 | 669862 | 157851 | 70098495 |
Cytomegalovirus infection | 148.18 | 10.29 | 97 | 672001 | 39661 | 70216685 |
Fatigue | 146.88 | 10.29 | 9364 | 662734 | 814955 | 69441391 |
Joint swelling | 143.52 | 10.29 | 1620 | 670478 | 251591 | 70004755 |
Balance disorder | 140.82 | 10.29 | 1389 | 670709 | 88739 | 70167607 |
Headache | 139.86 | 10.29 | 6780 | 665318 | 573625 | 69682721 |
Muscle spasms | 136.08 | 10.29 | 2133 | 669965 | 151913 | 70104433 |
Neutropenia | 135.06 | 10.29 | 1673 | 670425 | 255483 | 70000863 |
Infection | 134.30 | 10.29 | 1312 | 670786 | 209473 | 70046873 |
Maternal exposure during pregnancy | 133.32 | 10.29 | 600 | 671498 | 114745 | 70141601 |
Myalgia | 128.90 | 10.29 | 2272 | 669826 | 165620 | 70090726 |
Pyrexia | 128.20 | 10.29 | 4585 | 667513 | 602367 | 69653979 |
Multiple organ dysfunction syndrome | 124.50 | 10.29 | 566 | 671532 | 107949 | 70148397 |
Craniopharyngioma | 122.21 | 10.29 | 64 | 672034 | 326 | 70256020 |
Product substitution issue | 118.68 | 10.29 | 416 | 671682 | 18097 | 70238249 |
Hepatic function abnormal | 117.39 | 10.29 | 297 | 671801 | 67699 | 70188647 |
Intentional overdose | 116.80 | 10.29 | 507 | 671591 | 97928 | 70158418 |
Irritable bowel syndrome | 116.03 | 10.29 | 189 | 671909 | 50661 | 70205685 |
Transplant rejection | 113.55 | 10.29 | 18 | 672080 | 18153 | 70238193 |
Nausea | 111.55 | 10.29 | 9444 | 662654 | 842644 | 69413702 |
Bone marrow failure | 109.19 | 10.29 | 185 | 671913 | 48825 | 70207521 |
Vertigo | 108.58 | 10.29 | 987 | 671111 | 61656 | 70194690 |
Constipation | 107.88 | 10.29 | 3144 | 668954 | 249294 | 70007052 |
Feeling abnormal | 107.46 | 10.29 | 1921 | 670177 | 140398 | 70115948 |
Sedation complication | 105.43 | 10.29 | 323 | 671775 | 13087 | 70243259 |
Creatinine renal clearance decreased | 104.70 | 10.29 | 380 | 671718 | 16820 | 70239526 |
Product use issue | 103.55 | 10.29 | 1147 | 670951 | 178790 | 70077556 |
Orthostatic hypotension | 101.02 | 10.29 | 837 | 671261 | 50906 | 70205440 |
Myelosuppression | 98.87 | 10.29 | 84 | 672014 | 30061 | 70226285 |
Product prescribing error | 97.44 | 10.29 | 668 | 671430 | 38284 | 70218062 |
Blood calcium decreased | 97.00 | 10.29 | 534 | 671564 | 28312 | 70228034 |
Product quality issue | 92.44 | 10.29 | 550 | 671548 | 30011 | 70226335 |
Swelling | 91.05 | 10.29 | 1248 | 670850 | 187291 | 70069055 |
C-reactive protein abnormal | 89.32 | 10.29 | 142 | 671956 | 38437 | 70217909 |
Cognitive disorder | 88.75 | 10.29 | 926 | 671172 | 60030 | 70196316 |
Therapy non-responder | 87.72 | 10.29 | 402 | 671696 | 76513 | 70179833 |
Septic shock | 87.41 | 10.29 | 663 | 671435 | 111595 | 70144751 |
Autoimmune thyroiditis | 86.33 | 10.29 | 141 | 671957 | 3701 | 70252645 |
Death | 83.68 | 10.29 | 3965 | 668133 | 506096 | 69750250 |
Adrenocortical insufficiency acute | 83.05 | 10.29 | 114 | 671984 | 2552 | 70253794 |
Neurotoxicity | 81.92 | 10.29 | 97 | 672001 | 29729 | 70226617 |
Sepsis | 81.60 | 10.29 | 1731 | 670367 | 242814 | 70013532 |
Vision blurred | 81.49 | 10.29 | 1309 | 670789 | 93675 | 70162671 |
Abdominal discomfort | 78.64 | 10.29 | 1496 | 670602 | 213162 | 70043184 |
Dysgeusia | 78.32 | 10.29 | 765 | 671333 | 48737 | 70207609 |
Overdose | 77.91 | 10.29 | 1135 | 670963 | 168610 | 70087736 |
Toxic epidermal necrolysis | 77.81 | 10.29 | 161 | 671937 | 39396 | 70216950 |
Acute graft versus host disease | 77.39 | 10.29 | 3 | 672095 | 9559 | 70246787 |
Venoocclusive liver disease | 75.49 | 10.29 | 7 | 672091 | 10671 | 70245675 |
Sensitisation | 74.42 | 10.29 | 104 | 671994 | 2369 | 70253977 |
Post transplant lymphoproliferative disorder | 74.32 | 10.29 | 7 | 672091 | 10538 | 70245808 |
Diarrhoea | 72.93 | 10.29 | 8481 | 663617 | 774860 | 69481486 |
Pathogen resistance | 72.84 | 10.29 | 18 | 672080 | 13261 | 70243085 |
Syncope | 72.70 | 10.29 | 2071 | 670027 | 163638 | 70092708 |
Product complaint | 72.57 | 10.29 | 268 | 671830 | 11963 | 70244383 |
Haemophagocytic lymphohistiocytosis | 71.53 | 10.29 | 49 | 672049 | 19563 | 70236783 |
Urinary tract infection | 71.26 | 10.29 | 2959 | 669139 | 245810 | 70010536 |
Thyroid cancer | 70.74 | 10.29 | 153 | 671945 | 4992 | 70251354 |
Cardio-respiratory arrest | 70.40 | 10.29 | 612 | 671486 | 100065 | 70156281 |
Intentional product use issue | 70.22 | 10.29 | 763 | 671335 | 119379 | 70136967 |
Insulin-like growth factor increased | 69.69 | 10.29 | 85 | 672013 | 1686 | 70254660 |
Cardiac arrest | 68.80 | 10.29 | 1082 | 671016 | 158752 | 70097594 |
Neutrophil count decreased | 68.15 | 10.29 | 487 | 671611 | 83069 | 70173277 |
Gastrointestinal disorder | 68.02 | 10.29 | 654 | 671444 | 104773 | 70151573 |
Impaired healing | 67.94 | 10.29 | 419 | 671679 | 73955 | 70182391 |
Dehydration | 67.56 | 10.29 | 2702 | 669396 | 223440 | 70032906 |
Pneumocystis jirovecii pneumonia | 66.59 | 10.29 | 114 | 671984 | 29968 | 70226378 |
Dry skin | 66.20 | 10.29 | 816 | 671282 | 55115 | 70201231 |
Red blood cell sedimentation rate abnormal | 65.52 | 10.29 | 52 | 672046 | 19251 | 70237095 |
Hot flush | 65.14 | 10.29 | 738 | 671360 | 48846 | 70207500 |
Bronchopulmonary aspergillosis | 64.72 | 10.29 | 62 | 672036 | 20940 | 70235406 |
Disturbance in attention | 64.52 | 10.29 | 656 | 671442 | 42238 | 70214108 |
Stomatitis | 64.43 | 10.29 | 844 | 671254 | 127667 | 70128679 |
Pituitary tumour benign | 64.05 | 10.29 | 97 | 672001 | 2382 | 70253964 |
Haematotoxicity | 63.45 | 10.29 | 25 | 672073 | 13649 | 70242697 |
Myxoedema coma | 63.26 | 10.29 | 53 | 672045 | 655 | 70255691 |
Product formulation issue | 62.60 | 10.29 | 57 | 672041 | 793 | 70255553 |
Ill-defined disorder | 62.48 | 10.29 | 286 | 671812 | 54455 | 70201891 |
Pain in extremity | 62.30 | 10.29 | 3750 | 668348 | 324332 | 69932014 |
Drug dependence | 61.37 | 10.29 | 167 | 671931 | 37154 | 70219192 |
Suicide attempt | 61.22 | 10.29 | 471 | 671627 | 79039 | 70177307 |
Respiratory arrest | 60.83 | 10.29 | 283 | 671815 | 53650 | 70202696 |
Cystitis haemorrhagic | 59.78 | 10.29 | 6 | 672092 | 8587 | 70247759 |
Hepatotoxicity | 59.51 | 10.29 | 215 | 671883 | 43771 | 70212575 |
Enthesopathy | 59.10 | 10.29 | 15 | 672083 | 10854 | 70245492 |
Cytomegalovirus viraemia | 58.24 | 10.29 | 19 | 672079 | 11666 | 70244680 |
Prostate cancer | 57.84 | 10.29 | 131 | 671967 | 31032 | 70225314 |
Atrial fibrillation | 57.71 | 10.29 | 2214 | 669884 | 182134 | 70074212 |
C-reactive protein increased | 57.19 | 10.29 | 721 | 671377 | 109796 | 70146550 |
Dry mouth | 57.09 | 10.29 | 962 | 671136 | 69495 | 70186851 |
Substance abuse | 56.62 | 10.29 | 12 | 672086 | 9825 | 70246521 |
Aspergillus infection | 55.94 | 10.29 | 52 | 672046 | 17816 | 70238530 |
Dysphonia | 55.91 | 10.29 | 723 | 671375 | 49377 | 70206969 |
Transient ischaemic attack | 55.55 | 10.29 | 673 | 671425 | 45271 | 70211075 |
Thyroxine free increased | 54.83 | 10.29 | 62 | 672036 | 1131 | 70255215 |
Multiple-drug resistance | 54.27 | 10.29 | 4 | 672094 | 7351 | 70248995 |
Blister | 54.21 | 10.29 | 650 | 671448 | 99876 | 70156470 |
Graft versus host disease | 54.17 | 10.29 | 38 | 672060 | 14985 | 70241361 |
Papillary thyroid cancer | 54.09 | 10.29 | 89 | 672009 | 2351 | 70253995 |
Infective pulmonary exacerbation of cystic fibrosis | 53.56 | 10.29 | 24 | 672074 | 12134 | 70244212 |
Respiratory failure | 53.19 | 10.29 | 1205 | 670893 | 167530 | 70088816 |
Thyroid hormones decreased | 52.45 | 10.29 | 37 | 672061 | 347 | 70255999 |
Thrombocytopenia | 52.39 | 10.29 | 1797 | 670301 | 237313 | 70019033 |
Panniculitis | 52.09 | 10.29 | 18 | 672080 | 10658 | 70245688 |
Muscular weakness | 51.85 | 10.29 | 1696 | 670402 | 136640 | 70119706 |
Therapeutic response unexpected | 51.28 | 10.29 | 322 | 671776 | 17909 | 70238437 |
Flatulence | 50.93 | 10.29 | 570 | 671528 | 37611 | 70218735 |
Tremor | 50.85 | 10.29 | 1878 | 670220 | 153746 | 70102600 |
Diffuse alopecia | 50.71 | 10.29 | 45 | 672053 | 604 | 70255742 |
Musculoskeletal stiffness | 50.69 | 10.29 | 1041 | 671057 | 146719 | 70109627 |
Gait disturbance | 50.55 | 10.29 | 2191 | 669907 | 182915 | 70073431 |
Mucosal inflammation | 50.34 | 10.29 | 406 | 671692 | 67444 | 70188902 |
Thyroidectomy | 50.24 | 10.29 | 51 | 672047 | 818 | 70255528 |
Adenovirus infection | 50.14 | 10.29 | 7 | 672091 | 7761 | 70248585 |
Pituitary tumour recurrent | 50.03 | 10.29 | 26 | 672072 | 130 | 70256216 |
Cytokine release syndrome | 49.33 | 10.29 | 111 | 671987 | 26356 | 70229990 |
Oedema peripheral | 48.85 | 10.29 | 2636 | 669462 | 225455 | 70030891 |
Thyroid hormones increased | 47.96 | 10.29 | 36 | 672062 | 375 | 70255971 |
Malaise | 47.77 | 10.29 | 4742 | 667356 | 428190 | 69828156 |
Thyroxine free decreased | 47.63 | 10.29 | 53 | 672045 | 949 | 70255397 |
Bone pain | 47.24 | 10.29 | 710 | 671388 | 50112 | 70206234 |
Rheumatoid nodule | 46.99 | 10.29 | 44 | 672054 | 15023 | 70241323 |
Insulin-like growth factor decreased | 46.95 | 10.29 | 41 | 672057 | 538 | 70255808 |
Immune reconstitution inflammatory syndrome | 46.65 | 10.29 | 33 | 672065 | 12957 | 70243389 |
Blood thyroid stimulating hormone | 46.42 | 10.29 | 14 | 672084 | 6 | 70256340 |
Reaction to excipient | 46.41 | 10.29 | 63 | 672035 | 1395 | 70254951 |
Oral pain | 46.37 | 10.29 | 450 | 671648 | 28616 | 70227730 |
Disseminated intravascular coagulation | 46.26 | 10.29 | 163 | 671935 | 33435 | 70222911 |
Polycystic ovaries | 46.07 | 10.29 | 91 | 672007 | 2781 | 70253565 |
Weight decreased | 45.97 | 10.29 | 3476 | 668622 | 307012 | 69949334 |
Gastrooesophageal reflux disease | 45.73 | 10.29 | 1156 | 670942 | 89683 | 70166663 |
Product monitoring error | 44.94 | 10.29 | 154 | 671944 | 6622 | 70249724 |
Carpal tunnel syndrome | 44.74 | 10.29 | 296 | 671802 | 16761 | 70239585 |
Condition aggravated | 44.70 | 10.29 | 3467 | 668631 | 424168 | 69832178 |
Dysphagia | 44.01 | 10.29 | 1390 | 670708 | 111444 | 70144902 |
Chronic graft versus host disease | 43.94 | 10.29 | 6 | 672092 | 6764 | 70249582 |
Anaphylactic reaction | 43.46 | 10.29 | 477 | 671621 | 74497 | 70181849 |
Abdominal pain upper | 43.37 | 10.29 | 2247 | 669851 | 191355 | 70064991 |
Psoriatic arthropathy | 42.97 | 10.29 | 399 | 671699 | 64372 | 70191974 |
Decreased appetite | 42.95 | 10.29 | 3399 | 668699 | 301381 | 69954965 |
Acute myeloid leukaemia | 42.67 | 10.29 | 150 | 671948 | 30790 | 70225556 |
Pancytopenia | 42.44 | 10.29 | 1098 | 671000 | 150009 | 70106337 |
Drug tolerance decreased | 42.40 | 10.29 | 20 | 672078 | 9813 | 70246533 |
Hypopituitarism | 42.28 | 10.29 | 91 | 672007 | 2959 | 70253387 |
Bone erosion | 42.04 | 10.29 | 49 | 672049 | 15124 | 70241222 |
Tumour lysis syndrome | 41.95 | 10.29 | 87 | 672011 | 21273 | 70235073 |
Colorectal cancer | 41.82 | 10.29 | 14 | 672084 | 8456 | 70247890 |
Graft versus host disease in skin | 41.72 | 10.29 | 3 | 672095 | 5627 | 70250719 |
Hip fracture | 41.44 | 10.29 | 430 | 671668 | 27833 | 70228513 |
Ejection fraction | 41.41 | 10.29 | 66 | 672032 | 1696 | 70254650 |
Drug reaction with eosinophilia and systemic symptoms | 41.28 | 10.29 | 351 | 671747 | 57662 | 70198684 |
Tri-iodothyronine decreased | 41.05 | 10.29 | 26 | 672072 | 200 | 70256146 |
Therapeutic product effect incomplete | 40.70 | 10.29 | 846 | 671252 | 119036 | 70137310 |
Drug ineffective for unapproved indication | 40.69 | 10.29 | 207 | 671891 | 38331 | 70218015 |
Epstein-Barr virus infection | 40.62 | 10.29 | 39 | 672059 | 13159 | 70243187 |
Therapeutic response decreased | 40.55 | 10.29 | 356 | 671742 | 58097 | 70198249 |
Blood pressure increased | 40.42 | 10.29 | 2179 | 669919 | 186338 | 70070008 |
Exposure during pregnancy | 40.40 | 10.29 | 586 | 671512 | 87131 | 70169215 |
Aplastic anaemia | 40.16 | 10.29 | 60 | 672038 | 16656 | 70239690 |
Neutropenic sepsis | 40.16 | 10.29 | 112 | 671986 | 24718 | 70231628 |
Mucormycosis | 40.00 | 10.29 | 13 | 672085 | 8001 | 70248345 |
Poisoning | 39.67 | 10.29 | 98 | 672000 | 22524 | 70233822 |
Cytomegalovirus infection reactivation | 39.59 | 10.29 | 8 | 672090 | 6773 | 70249573 |
Blood parathyroid hormone decreased | 39.46 | 10.29 | 18 | 672080 | 9006 | 70247340 |
Nephropathy toxic | 39.32 | 10.29 | 72 | 672026 | 18442 | 70237904 |
Therapeutic drug monitoring analysis not performed | 39.31 | 10.29 | 60 | 672038 | 1484 | 70254862 |
Hip arthroplasty | 39.31 | 10.29 | 135 | 671963 | 27905 | 70228441 |
Thrombotic microangiopathy | 39.17 | 10.29 | 68 | 672030 | 17780 | 70238566 |
Full blood count abnormal | 38.69 | 10.29 | 491 | 671607 | 33387 | 70222959 |
Myxoedema | 38.61 | 10.29 | 21 | 672077 | 117 | 70256229 |
Swollen tongue | 38.59 | 10.29 | 528 | 671570 | 36518 | 70219828 |
Gestational diabetes | 38.59 | 10.29 | 135 | 671963 | 5866 | 70250480 |
Acute graft versus host disease in skin | 38.52 | 10.29 | 10 | 672088 | 7127 | 70249219 |
Influenza like illness | 37.95 | 10.29 | 848 | 671250 | 64483 | 70191863 |
Device adhesion issue | 37.90 | 10.29 | 6 | 672092 | 6057 | 70250289 |
Hypertension | 37.80 | 10.29 | 3277 | 668821 | 292756 | 69963590 |
Polyomavirus-associated nephropathy | 37.73 | 10.29 | 3 | 672095 | 5180 | 70251166 |
Insomnia | 37.69 | 10.29 | 2470 | 669628 | 215336 | 70041010 |
Ankylosing spondylitis | 37.52 | 10.29 | 33 | 672065 | 11613 | 70244733 |
Thyroid cancer recurrent | 37.41 | 10.29 | 13 | 672085 | 16 | 70256330 |
Anxiety | 37.30 | 10.29 | 2494 | 669604 | 217836 | 70038510 |
Disease progression | 37.25 | 10.29 | 1165 | 670933 | 155507 | 70100839 |
Sickle cell anaemia with crisis | 37.18 | 10.29 | 6 | 672092 | 5972 | 70250374 |
Thyroxine increased | 36.98 | 10.29 | 40 | 672058 | 693 | 70255653 |
Graft versus host disease in gastrointestinal tract | 36.89 | 10.29 | 6 | 672092 | 5938 | 70250408 |
Transplant dysfunction | 36.68 | 10.29 | 10 | 672088 | 6899 | 70249447 |
BK virus infection | 36.42 | 10.29 | 15 | 672083 | 7974 | 70248372 |
Cytomegalovirus chorioretinitis | 36.09 | 10.29 | 4 | 672094 | 5294 | 70251052 |
Hypophysitis | 35.82 | 10.29 | 97 | 672001 | 3661 | 70252685 |
General physical health deterioration | 35.50 | 10.29 | 2646 | 669452 | 233385 | 70022961 |
Nervousness | 35.10 | 10.29 | 450 | 671648 | 30670 | 70225676 |
Ageusia | 34.89 | 10.29 | 251 | 671847 | 14611 | 70241735 |
Amnesia | 34.85 | 10.29 | 691 | 671407 | 51464 | 70204882 |
Drug use disorder | 34.51 | 10.29 | 17 | 672081 | 8134 | 70248212 |
Status epilepticus | 34.43 | 10.29 | 118 | 671980 | 24408 | 70231938 |
Burning sensation | 34.17 | 10.29 | 697 | 671401 | 52173 | 70204173 |
Juvenile idiopathic arthritis | 33.54 | 10.29 | 7 | 672091 | 5793 | 70250553 |
Pseudomonas infection | 33.53 | 10.29 | 82 | 672016 | 18912 | 70237434 |
Dystonia | 33.29 | 10.29 | 87 | 672011 | 19619 | 70236727 |
Red blood cell sedimentation rate | 32.71 | 10.29 | 4 | 672094 | 4906 | 70251440 |
Plasma cell myeloma | 32.68 | 10.29 | 492 | 671606 | 72709 | 70183637 |
Chronic pigmented purpura | 32.09 | 10.29 | 21 | 672077 | 172 | 70256174 |
Dyspnoea | 31.83 | 10.29 | 7985 | 664113 | 762075 | 69494271 |
Rheumatic fever | 31.36 | 10.29 | 76 | 672022 | 17584 | 70238762 |
Trichorrhexis | 31.27 | 10.29 | 37 | 672061 | 710 | 70255636 |
Tenderness | 31.24 | 10.29 | 323 | 671775 | 20887 | 70235459 |
Body height decreased | 30.96 | 10.29 | 151 | 671947 | 7632 | 70248714 |
Reversible airways obstruction | 30.86 | 10.29 | 55 | 672043 | 1552 | 70254794 |
Memory impairment | 30.49 | 10.29 | 1119 | 670979 | 91522 | 70164824 |
Goitre | 30.49 | 10.29 | 113 | 671985 | 5053 | 70251293 |
Cerebrovascular accident | 30.48 | 10.29 | 1657 | 670441 | 141813 | 70114533 |
Interstitial lung disease | 30.37 | 10.29 | 757 | 671341 | 103928 | 70152418 |
Pulmonary malformation | 30.15 | 10.29 | 20 | 672078 | 168 | 70256178 |
Nocardiosis | 30.05 | 10.29 | 6 | 672092 | 5123 | 70251223 |
Unintentional medical device removal | 29.95 | 10.29 | 15 | 672083 | 7109 | 70249237 |
Feeling cold | 29.80 | 10.29 | 372 | 671726 | 25198 | 70231148 |
Foreign body in reproductive tract | 29.74 | 10.29 | 29 | 672069 | 442 | 70255904 |
Blood glucose increased | 29.68 | 10.29 | 1226 | 670872 | 101756 | 70154590 |
Dyspepsia | 29.58 | 10.29 | 1077 | 671021 | 88000 | 70168346 |
Pulmonary tuberculosis | 29.42 | 10.29 | 19 | 672079 | 7826 | 70248520 |
Swollen joint count increased | 29.34 | 10.29 | 53 | 672045 | 13647 | 70242699 |
Myelodysplastic syndrome | 29.21 | 10.29 | 164 | 671934 | 29621 | 70226725 |
Paraesthesia | 29.18 | 10.29 | 1672 | 670426 | 143865 | 70112481 |
Coma | 29.18 | 10.29 | 655 | 671443 | 91189 | 70165157 |
Acute respiratory distress syndrome | 29.17 | 10.29 | 250 | 671848 | 41004 | 70215342 |
Epiphysiolysis | 29.16 | 10.29 | 16 | 672082 | 91 | 70256255 |
Swelling face | 28.95 | 10.29 | 794 | 671304 | 62370 | 70193976 |
Cardiogenic shock | 28.93 | 10.29 | 213 | 671885 | 36094 | 70220252 |
Rash | 28.74 | 10.29 | 4322 | 667776 | 506240 | 69750106 |
Hypoglycaemia | 28.72 | 10.29 | 1130 | 670968 | 93234 | 70163112 |
Gallbladder disorder | 28.64 | 10.29 | 275 | 671823 | 17437 | 70238909 |
Lymphocyte count decreased | 28.53 | 10.29 | 269 | 671829 | 43270 | 70213076 |
Oesophageal carcinoma | 28.45 | 10.29 | 28 | 672070 | 9338 | 70247008 |
Liver injury | 28.43 | 10.29 | 250 | 671848 | 40785 | 70215561 |
Alopecia | 28.40 | 10.29 | 1564 | 670534 | 196926 | 70059420 |
Accidental exposure to product | 28.31 | 10.29 | 153 | 671945 | 27898 | 70228448 |
Tenosynovitis | 28.24 | 10.29 | 56 | 672042 | 13920 | 70242426 |
Drug eruption | 28.08 | 10.29 | 239 | 671859 | 39257 | 70217089 |
Diffuse large B-cell lymphoma | 28.01 | 10.29 | 52 | 672046 | 13250 | 70243096 |
Product dose omission issue | 28 | 10.29 | 2409 | 669689 | 215059 | 70041287 |
Product physical issue | 27.85 | 10.29 | 88 | 672010 | 3626 | 70252720 |
Tropical infectious disease | 27.73 | 10.29 | 12 | 672086 | 36 | 70256310 |
Respiratory depression | 27.58 | 10.29 | 131 | 671967 | 24700 | 70231646 |
Visual impairment | 27.56 | 10.29 | 974 | 671124 | 79276 | 70177070 |
Dry eye | 27.34 | 10.29 | 444 | 671654 | 31838 | 70224508 |
Jaw disorder | 27.33 | 10.29 | 103 | 671995 | 4643 | 70251703 |
Eye swelling | 27.29 | 10.29 | 343 | 671755 | 23271 | 70233075 |
Hypersomnia | 27.24 | 10.29 | 309 | 671789 | 20455 | 70235891 |
Autoimmune hepatitis | 26.98 | 10.29 | 185 | 671913 | 10601 | 70245745 |
Therapy partial responder | 26.95 | 10.29 | 48 | 672050 | 12426 | 70243920 |
Pneumonia | 26.86 | 10.29 | 5110 | 666988 | 591122 | 69665224 |
Skin necrosis | 26.71 | 10.29 | 73 | 672025 | 16218 | 70240128 |
Sedation | 26.64 | 10.29 | 605 | 671493 | 46126 | 70210220 |
Product taste abnormal | 26.54 | 10.29 | 61 | 672037 | 2075 | 70254271 |
Thyrotoxic crisis | 26.37 | 10.29 | 44 | 672054 | 1176 | 70255170 |
Cardiotoxicity | 26.34 | 10.29 | 40 | 672058 | 11030 | 70245316 |
Bacteraemia | 26.30 | 10.29 | 166 | 671932 | 29143 | 70227203 |
Granulocytopenia | 26.27 | 10.29 | 182 | 671916 | 10465 | 70245881 |
Acute lymphocytic leukaemia recurrent | 26.22 | 10.29 | 7 | 672091 | 4897 | 70251449 |
Cardiac disorder | 26.15 | 10.29 | 743 | 671355 | 58672 | 70197674 |
Oral discomfort | 26.11 | 10.29 | 158 | 671940 | 8673 | 70247673 |
Sciatica | 26.06 | 10.29 | 352 | 671746 | 24275 | 70232071 |
Haemorrhoids | 25.96 | 10.29 | 363 | 671735 | 25225 | 70231121 |
Skin haemorrhage | 25.70 | 10.29 | 175 | 671923 | 10005 | 70246341 |
Eating disorder | 25.60 | 10.29 | 279 | 671819 | 18286 | 70238060 |
Nasopharyngitis | 25.49 | 10.29 | 1787 | 670311 | 220419 | 70035927 |
Spinal stenosis | 25.44 | 10.29 | 231 | 671867 | 14422 | 70241924 |
Lip swelling | 25.44 | 10.29 | 459 | 671639 | 33595 | 70222751 |
Breast cancer stage I | 25.42 | 10.29 | 13 | 672085 | 6089 | 70250257 |
Haematoma | 25.21 | 10.29 | 619 | 671479 | 47799 | 70208547 |
Disorientation | 25.12 | 10.29 | 723 | 671375 | 57200 | 70199146 |
Device difficult to use | 25.05 | 10.29 | 40 | 672058 | 10809 | 70245537 |
Somatic delusion | 24.99 | 10.29 | 32 | 672066 | 668 | 70255678 |
Hypoacusis | 24.97 | 10.29 | 380 | 671718 | 26889 | 70229457 |
Alanine aminotransferase increased | 24.77 | 10.29 | 1143 | 670955 | 146337 | 70110009 |
Product odour abnormal | 24.77 | 10.29 | 43 | 672055 | 1188 | 70255158 |
Poisoning deliberate | 24.69 | 10.29 | 81 | 672017 | 16979 | 70239367 |
Pneumonia fungal | 24.62 | 10.29 | 35 | 672063 | 9918 | 70246428 |
Alanine aminotransferase abnormal | 24.59 | 10.29 | 24 | 672074 | 8035 | 70248311 |
Lipodystrophy acquired | 24.56 | 10.29 | 5 | 672093 | 4211 | 70252135 |
Arrhythmia | 24.40 | 10.29 | 701 | 671397 | 55442 | 70200904 |
Head injury | 24.40 | 10.29 | 457 | 671641 | 33684 | 70222662 |
Serotonin syndrome | 24.38 | 10.29 | 268 | 671830 | 41846 | 70214500 |
Secondary hypogonadism | 24.31 | 10.29 | 23 | 672075 | 337 | 70256009 |
Febrile bone marrow aplasia | 24.27 | 10.29 | 48 | 672050 | 11943 | 70244403 |
Systemic infection | 24.26 | 10.29 | 126 | 671972 | 6531 | 70249815 |
Blood growth hormone increased | 24.22 | 10.29 | 31 | 672067 | 647 | 70255699 |
Rhinitis allergic | 24.20 | 10.29 | 161 | 671937 | 9134 | 70247212 |
Enterococcal infection | 24.16 | 10.29 | 65 | 672033 | 14517 | 70241829 |
Retinitis | 24.10 | 10.29 | 5 | 672093 | 4155 | 70252191 |
Labyrinthitis | 24.03 | 10.29 | 69 | 672029 | 2695 | 70253651 |
Diverticulum | 23.84 | 10.29 | 216 | 671882 | 13477 | 70242869 |
Incorrect route of product administration | 23.80 | 10.29 | 150 | 671948 | 26342 | 70230004 |
Product colour issue | 23.76 | 10.29 | 32 | 672066 | 703 | 70255643 |
Paradoxical drug reaction | 23.65 | 10.29 | 17 | 672081 | 6619 | 70249727 |
Thyroxine decreased | 23.51 | 10.29 | 33 | 672065 | 755 | 70255591 |
Broncholithiasis | 23.33 | 10.29 | 18 | 672080 | 196 | 70256150 |
Choking | 23.26 | 10.29 | 182 | 671916 | 10878 | 70245468 |
Urine odour abnormal | 22.82 | 10.29 | 110 | 671988 | 5533 | 70250813 |
Diffuse large B-cell lymphoma recurrent | 22.75 | 10.29 | 3 | 672095 | 3473 | 70252873 |
Retrograde amnesia | 22.71 | 10.29 | 27 | 672071 | 521 | 70255825 |
Malabsorption | 22.60 | 10.29 | 96 | 672002 | 4574 | 70251772 |
Inner ear disorder | 22.59 | 10.29 | 27 | 672071 | 524 | 70255822 |
Haematochezia | 22.44 | 10.29 | 876 | 671222 | 72205 | 70184141 |
Change of bowel habit | 22.10 | 10.29 | 65 | 672033 | 2574 | 70253772 |
Tri-iodothyronine increased | 22.05 | 10.29 | 18 | 672080 | 214 | 70256132 |
Papillitis | 21.99 | 10.29 | 13 | 672085 | 87 | 70256259 |
Chest pain | 21.98 | 10.29 | 2711 | 669387 | 248549 | 70007797 |
Head discomfort | 21.95 | 10.29 | 204 | 671894 | 12819 | 70243527 |
Hiatus hernia | 21.92 | 10.29 | 301 | 671797 | 20833 | 70235513 |
Anti-thyroid antibody positive | 21.90 | 10.29 | 25 | 672073 | 461 | 70255885 |
Pelvic fracture | 21.89 | 10.29 | 182 | 671916 | 11079 | 70245267 |
Blood glucose decreased | 21.86 | 10.29 | 336 | 671762 | 23823 | 70232523 |
Intentional self-injury | 21.84 | 10.29 | 193 | 671905 | 31457 | 70224889 |
Hypogammaglobulinaemia | 21.82 | 10.29 | 48 | 672050 | 11490 | 70244856 |
Nephritic syndrome | 21.80 | 10.29 | 21 | 672077 | 315 | 70256031 |
Pneumonia cytomegaloviral | 21.73 | 10.29 | 8 | 672090 | 4553 | 70251793 |
Viral mutation identified | 21.72 | 10.29 | 4 | 672094 | 3618 | 70252728 |
Cholelithiasis | 21.67 | 10.29 | 595 | 671503 | 46745 | 70209601 |
Vaginal haemorrhage | 21.58 | 10.29 | 291 | 671807 | 20061 | 70236285 |
Atrioventricular block | 21.51 | 10.29 | 199 | 671899 | 12489 | 70243857 |
Posterior reversible encephalopathy syndrome | 21.49 | 10.29 | 139 | 671959 | 24263 | 70232083 |
Liver function test abnormal | 21.46 | 10.29 | 744 | 671354 | 60402 | 70195944 |
Breast cancer stage III | 21.44 | 10.29 | 19 | 672079 | 6662 | 70249684 |
Back pain | 21.36 | 10.29 | 2907 | 669191 | 268245 | 69988101 |
Lymphoproliferative disorder | 21.25 | 10.29 | 12 | 672086 | 5317 | 70251029 |
Eye irritation | 21.25 | 10.29 | 260 | 671838 | 17528 | 70238818 |
Exposure via ingestion | 21.19 | 10.29 | 10 | 672088 | 4905 | 70251441 |
Pneumatosis intestinalis | 21.08 | 10.29 | 15 | 672083 | 5872 | 70250474 |
Primary hypothyroidism | 21.06 | 10.29 | 15 | 672083 | 143 | 70256203 |
Cerebral infarction | 20.98 | 10.29 | 284 | 671814 | 42725 | 70213621 |
Bradycardia | 20.97 | 10.29 | 1410 | 670688 | 123205 | 70133141 |
Gastric cancer | 20.69 | 10.29 | 33 | 672065 | 8922 | 70247424 |
Poor quality product administered | 20.62 | 10.29 | 74 | 672024 | 3257 | 70253089 |
Tongue discomfort | 20.61 | 10.29 | 57 | 672041 | 2178 | 70254168 |
Hyperhidrosis | 20.59 | 10.29 | 1480 | 670618 | 130106 | 70126240 |
Leukopenia | 20.58 | 10.29 | 813 | 671285 | 105747 | 70150599 |
Multiple allergies | 20.56 | 10.29 | 135 | 671963 | 7625 | 70248721 |
Staphylococcal infection | 20.52 | 10.29 | 369 | 671729 | 53035 | 70203311 |
Abdominal distension | 20.50 | 10.29 | 1200 | 670898 | 103469 | 70152877 |
Persistent depressive disorder | 20.47 | 10.29 | 36 | 672062 | 1005 | 70255341 |
Scleral discolouration | 20.41 | 10.29 | 26 | 672072 | 540 | 70255806 |
Immunosuppressant drug level increased | 20.37 | 10.29 | 27 | 672071 | 7880 | 70248466 |
Diabetes insipidus | 20.32 | 10.29 | 93 | 672005 | 4578 | 70251768 |
Lip blister | 20.31 | 10.29 | 60 | 672038 | 2382 | 70253964 |
Intervertebral disc protrusion | 20.21 | 10.29 | 301 | 671797 | 21202 | 70235144 |
Skin toxicity | 20.21 | 10.29 | 23 | 672075 | 7175 | 70249171 |
Metastatic renal cell carcinoma | 20.19 | 10.29 | 67 | 672031 | 2833 | 70253513 |
Sleep disorder due to a general medical condition | 20.19 | 10.29 | 169 | 671929 | 10307 | 70246039 |
Medullary thyroid cancer | 20.16 | 10.29 | 15 | 672083 | 154 | 70256192 |
Milk-alkali syndrome | 20.14 | 10.29 | 39 | 672059 | 1174 | 70255172 |
Metabolic acidosis | 20.13 | 10.29 | 543 | 671555 | 73803 | 70182543 |
Soft tissue disorder | 20.08 | 10.29 | 74 | 672024 | 3300 | 70253046 |
Kidney transplant rejection | 20.05 | 10.29 | 40 | 672058 | 9921 | 70246425 |
Breast cancer stage II | 19.98 | 10.29 | 13 | 672085 | 5333 | 70251013 |
Cerebral haematoma | 19.94 | 10.29 | 129 | 671969 | 7249 | 70249097 |
Medulloblastoma recurrent | 19.87 | 10.29 | 14 | 672084 | 131 | 70256215 |
Pre-existing condition improved | 19.87 | 10.29 | 97 | 672001 | 4905 | 70251441 |
Ventricular fibrillation | 19.75 | 10.29 | 163 | 671935 | 26948 | 70229398 |
Growth hormone deficiency | 19.73 | 10.29 | 22 | 672076 | 395 | 70255951 |
Bladder cancer | 19.72 | 10.29 | 90 | 672008 | 17152 | 70239194 |
Platelet count decreased | 19.66 | 10.29 | 1438 | 670660 | 176784 | 70079562 |
Virologic failure | 19.65 | 10.29 | 6 | 672092 | 3844 | 70252502 |
Drug abuser | 19.65 | 10.29 | 16 | 672082 | 5848 | 70250498 |
Pollakiuria | 19.64 | 10.29 | 435 | 671663 | 33026 | 70223320 |
Thyroiditis | 19.56 | 10.29 | 83 | 672015 | 3953 | 70252393 |
Exposure to toxic agent | 19.42 | 10.29 | 18 | 672080 | 6176 | 70250170 |
Low turnover osteopathy | 19.38 | 10.29 | 50 | 672048 | 1832 | 70254514 |
Intentional product misuse | 19.36 | 10.29 | 590 | 671508 | 79005 | 70177341 |
Adrenal insufficiency | 19.32 | 10.29 | 341 | 671757 | 24854 | 70231492 |
Altered state of consciousness | 19.26 | 10.29 | 265 | 671833 | 39757 | 70216589 |
Tooth fracture | 19.21 | 10.29 | 169 | 671929 | 10458 | 70245888 |
Disability | 19.12 | 10.29 | 75 | 672023 | 14908 | 70241438 |
Extremity contracture | 19.09 | 10.29 | 46 | 672052 | 1614 | 70254732 |
Blood test abnormal | 19.09 | 10.29 | 217 | 671881 | 14373 | 70241973 |
Upper limb fracture | 19.00 | 10.29 | 235 | 671863 | 15884 | 70240462 |
Lung cyst | 18.90 | 10.29 | 18 | 672080 | 266 | 70256080 |
Brain oedema | 18.84 | 10.29 | 137 | 671961 | 23281 | 70233065 |
Lymphadenectomy | 18.81 | 10.29 | 37 | 672061 | 1127 | 70255219 |
Thyroid cancer metastatic | 18.72 | 10.29 | 14 | 672084 | 145 | 70256201 |
Application site erythema | 18.68 | 10.29 | 92 | 672006 | 4669 | 70251677 |
Thyrotoxic periodic paralysis | 18.57 | 10.29 | 12 | 672086 | 96 | 70256250 |
Electrocardiogram ST segment elevation | 18.55 | 10.29 | 27 | 672071 | 7577 | 70248769 |
Vital capacity decreased | 18.35 | 10.29 | 41 | 672057 | 1368 | 70254978 |
Pancreatic neuroendocrine tumour | 18.34 | 10.29 | 27 | 672071 | 646 | 70255700 |
Labile hypertension | 18.28 | 10.29 | 24 | 672074 | 514 | 70255832 |
Anosmia | 18.20 | 10.29 | 93 | 672005 | 4790 | 70251556 |
Exophthalmos | 18.15 | 10.29 | 44 | 672054 | 1550 | 70254796 |
Respiratory disorder | 18.14 | 10.29 | 261 | 671837 | 38862 | 70217484 |
Gastrointestinal motility disorder | 18.02 | 10.29 | 102 | 671996 | 5464 | 70250882 |
Erythema dyschromicum perstans | 17.93 | 10.29 | 10 | 672088 | 59 | 70256287 |
Pituitary tumour | 17.90 | 10.29 | 36 | 672062 | 1115 | 70255231 |
Wrist fracture | 17.86 | 10.29 | 165 | 671933 | 10351 | 70245995 |
Myocardial infarction | 17.82 | 10.29 | 1392 | 670706 | 170253 | 70086093 |
Spinal osteoarthritis | 17.76 | 10.29 | 223 | 671875 | 15125 | 70241221 |
Cytopenia | 17.75 | 10.29 | 94 | 672004 | 17229 | 70239117 |
Product measured potency issue | 17.73 | 10.29 | 15 | 672083 | 188 | 70256158 |
Systemic candida | 17.73 | 10.29 | 18 | 672080 | 5916 | 70250430 |
Cystitis | 17.70 | 10.29 | 576 | 671522 | 46365 | 70209981 |
Hyperchromic anaemia | 17.67 | 10.29 | 14 | 672084 | 159 | 70256187 |
Acute graft versus host disease in intestine | 17.67 | 10.29 | 7 | 672091 | 3809 | 70252537 |
Endocrine ophthalmopathy | 17.56 | 10.29 | 24 | 672074 | 535 | 70255811 |
Increased tendency to bruise | 17.56 | 10.29 | 154 | 671944 | 9521 | 70246825 |
Oropharyngeal pain | 17.51 | 10.29 | 1097 | 671001 | 95213 | 70161133 |
Thyroxine abnormal | 17.44 | 10.29 | 6 | 672092 | 7 | 70256339 |
Drug level increased | 17.36 | 10.29 | 242 | 671856 | 36227 | 70220119 |
Multiple drug therapy | 17.34 | 10.29 | 68 | 672030 | 3124 | 70253222 |
Follicular thyroid cancer | 17.33 | 10.29 | 11 | 672087 | 85 | 70256261 |
Staphylococcal sepsis | 17.27 | 10.29 | 67 | 672031 | 13360 | 70242986 |
Hyperbilirubinaemia | 17.22 | 10.29 | 134 | 671964 | 22434 | 70233912 |
Bladder disorder | 17.21 | 10.29 | 136 | 671962 | 8153 | 70248193 |
Cryptococcosis | 17.18 | 10.29 | 5 | 672093 | 3305 | 70253041 |
Endocrine disorder | 17.17 | 10.29 | 28 | 672070 | 734 | 70255612 |
Weight increased | 17.15 | 10.29 | 2582 | 669516 | 239749 | 70016597 |
Adverse event | 17.09 | 10.29 | 348 | 671750 | 49113 | 70207233 |
Amniotic fluid volume increased | 17.04 | 10.29 | 13 | 672085 | 139 | 70256207 |
Breast discomfort | 16.91 | 10.29 | 19 | 672079 | 344 | 70256002 |
Knee arthroplasty | 16.91 | 10.29 | 226 | 671872 | 34075 | 70222271 |
Rapid eye movement sleep behaviour disorder | 16.83 | 10.29 | 19 | 672079 | 346 | 70256000 |
Adenoiditis | 16.78 | 10.29 | 8 | 672090 | 32 | 70256314 |
Product solubility abnormal | 16.77 | 10.29 | 30 | 672068 | 849 | 70255497 |
Palmar-plantar erythrodysaesthesia syndrome | 16.75 | 10.29 | 390 | 671708 | 29857 | 70226489 |
Transcription medication error | 16.74 | 10.29 | 19 | 672079 | 348 | 70255998 |
Hypertensive crisis | 16.71 | 10.29 | 266 | 671832 | 18996 | 70237350 |
Full blood count decreased | 16.69 | 10.29 | 319 | 671779 | 23599 | 70232747 |
Pneumonia bacterial | 16.66 | 10.29 | 91 | 672007 | 16550 | 70239796 |
Ascites | 16.60 | 10.29 | 500 | 671598 | 67047 | 70189299 |
Hypoxia | 16.57 | 10.29 | 719 | 671379 | 92625 | 70163721 |
Neurologic neglect syndrome | 16.57 | 10.29 | 55 | 672043 | 2326 | 70254020 |
Fungaemia | 16.56 | 10.29 | 9 | 672089 | 4073 | 70252273 |
Total lung capacity abnormal | 16.45 | 10.29 | 14 | 672084 | 177 | 70256169 |
Traumatic ulcer | 16.43 | 10.29 | 9 | 672089 | 51 | 70256295 |
Anaphylactic shock | 16.41 | 10.29 | 213 | 671885 | 32277 | 70224069 |
Cataract | 16.38 | 10.29 | 664 | 671434 | 54981 | 70201365 |
Nasal congestion | 16.30 | 10.29 | 770 | 671328 | 64902 | 70191444 |
Granuloma | 16.27 | 10.29 | 30 | 672068 | 7665 | 70248681 |
Renal impairment | 16.26 | 10.29 | 1159 | 670939 | 142778 | 70113568 |
Kounis syndrome | 16.22 | 10.29 | 6 | 672092 | 3405 | 70252941 |
Upper-airway cough syndrome | 16.19 | 10.29 | 152 | 671946 | 9579 | 70246767 |
Oculogyric crisis | 16.14 | 10.29 | 3 | 672095 | 2695 | 70253651 |
Lymph node calcification | 16.12 | 10.29 | 19 | 672079 | 363 | 70255983 |
Aggression | 16.10 | 10.29 | 343 | 671755 | 48103 | 70208243 |
Arterial occlusive disease | 16.06 | 10.29 | 127 | 671971 | 7615 | 70248731 |
Lactose intolerance | 16.06 | 10.29 | 51 | 672047 | 2107 | 70254239 |
Thyroglobulin decreased | 16.02 | 10.29 | 5 | 672093 | 3 | 70256343 |
Venoocclusive disease | 15.99 | 10.29 | 10 | 672088 | 4190 | 70252156 |
Potassium wasting nephropathy | 15.76 | 10.29 | 13 | 672085 | 157 | 70256189 |
Stenotrophomonas infection | 15.74 | 10.29 | 6 | 672092 | 3343 | 70253003 |
Cervicogenic headache | 15.71 | 10.29 | 7 | 672091 | 23 | 70256323 |
Intercepted product preparation error | 15.67 | 10.29 | 3 | 672095 | 2639 | 70253707 |
Presbyacusis | 15.63 | 10.29 | 3 | 672095 | 2634 | 70253712 |
Pregnancy | 15.55 | 10.29 | 147 | 671951 | 23634 | 70232712 |
Blood loss anaemia | 15.52 | 10.29 | 207 | 671891 | 14234 | 70242112 |
International normalised ratio increased | 15.52 | 10.29 | 924 | 671174 | 79802 | 70176544 |
Gastritis | 15.50 | 10.29 | 542 | 671556 | 44049 | 70212297 |
Tooth dislocation | 15.49 | 10.29 | 7 | 672091 | 24 | 70256322 |
Delayed graft function | 15.47 | 10.29 | 6 | 672092 | 3307 | 70253039 |
Vascular stent thrombosis | 15.45 | 10.29 | 7 | 672091 | 3516 | 70252830 |
Meniere's disease | 15.43 | 10.29 | 13 | 672085 | 162 | 70256184 |
Intercapillary glomerulosclerosis | 15.38 | 10.29 | 9 | 672089 | 59 | 70256287 |
Abdominal pain lower | 15.37 | 10.29 | 363 | 671735 | 27853 | 70228493 |
Rib deformity | 15.36 | 10.29 | 13 | 672085 | 163 | 70256183 |
Dysstasia | 15.31 | 10.29 | 329 | 671769 | 24850 | 70231496 |
Scar | 15.28 | 10.29 | 201 | 671897 | 13780 | 70242566 |
Product administered to patient of inappropriate age | 15.27 | 10.29 | 14 | 672084 | 4829 | 70251517 |
Diabetic ketoacidosis | 15.26 | 10.29 | 399 | 671699 | 31113 | 70225233 |
Intervertebral disc degeneration | 15.26 | 10.29 | 200 | 671898 | 13700 | 70242646 |
Faeces discoloured | 15.25 | 10.29 | 347 | 671751 | 26462 | 70229884 |
Blood calcium increased | 15.22 | 10.29 | 141 | 671957 | 8852 | 70247494 |
Gingival pain | 15.22 | 10.29 | 113 | 671985 | 6644 | 70249702 |
Cystic fibrosis | 15.21 | 10.29 | 11 | 672087 | 4270 | 70252076 |
Abdominal pain | 15.20 | 10.29 | 3560 | 668538 | 338567 | 69917779 |
Device related infection | 15.17 | 10.29 | 214 | 671884 | 31971 | 70224375 |
Device use error | 15.17 | 10.29 | 25 | 672073 | 6671 | 70249675 |
Eye pain | 15.15 | 10.29 | 427 | 671671 | 33675 | 70222671 |
Hepatitis B | 15.15 | 10.29 | 34 | 672064 | 8080 | 70248266 |
Sinus bradycardia | 15.12 | 10.29 | 311 | 671787 | 23312 | 70233034 |
Femur fracture | 15.11 | 10.29 | 449 | 671649 | 35683 | 70220663 |
Injection site mass | 15.05 | 10.29 | 251 | 671847 | 18092 | 70238254 |
Temperature regulation disorder | 15.05 | 10.29 | 12 | 672086 | 4432 | 70251914 |
Pleural neoplasm | 14.99 | 10.29 | 18 | 672080 | 351 | 70255995 |
Rheumatoid lung | 14.97 | 10.29 | 7 | 672091 | 3452 | 70252894 |
Product blister packaging issue | 14.92 | 10.29 | 13 | 672085 | 170 | 70256176 |
Cytomegalovirus colitis | 14.83 | 10.29 | 11 | 672087 | 4215 | 70252131 |
Listless | 14.80 | 10.29 | 70 | 672028 | 3493 | 70252853 |
Decreased bronchial secretion | 14.78 | 10.29 | 9 | 672089 | 64 | 70256282 |
Shock | 14.69 | 10.29 | 282 | 671816 | 40143 | 70216203 |
Vessel puncture site haemorrhage | 14.68 | 10.29 | 13 | 672085 | 174 | 70256172 |
Polyglandular autoimmune syndrome type II | 14.68 | 10.29 | 7 | 672091 | 28 | 70256318 |
Tonsillar cyst | 14.67 | 10.29 | 4 | 672094 | 0 | 70256346 |
Magnetic resonance imaging thoracic abnormal | 14.64 | 10.29 | 6 | 672092 | 15 | 70256331 |
N-terminal prohormone brain natriuretic peptide abnormal | 14.56 | 10.29 | 15 | 672083 | 245 | 70256101 |
Ileus paralytic | 14.55 | 10.29 | 39 | 672059 | 8722 | 70247624 |
Atrioventricular block first degree | 14.55 | 10.29 | 172 | 671926 | 11501 | 70244845 |
Parainfluenzae virus infection | 14.51 | 10.29 | 16 | 672082 | 5064 | 70251282 |
Drug specific antibody present | 14.49 | 10.29 | 20 | 672078 | 5738 | 70250608 |
Skin exfoliation | 14.49 | 10.29 | 581 | 671517 | 48045 | 70208301 |
Neuroleptic malignant syndrome | 14.46 | 10.29 | 167 | 671931 | 25840 | 70230506 |
Viraemia | 14.42 | 10.29 | 3 | 672095 | 2489 | 70253857 |
Impaired driving ability | 14.42 | 10.29 | 87 | 672011 | 4770 | 70251576 |
Depression | 14.42 | 10.29 | 2123 | 669975 | 196851 | 70059495 |
Vaccination site reaction | 14.39 | 10.29 | 11 | 672087 | 118 | 70256228 |
Intentional underdose | 14.39 | 10.29 | 49 | 672049 | 2100 | 70254246 |
Seronegative arthritis | 14.38 | 10.29 | 7 | 672091 | 3372 | 70252974 |
Anaemia vitamin B12 deficiency | 14.37 | 10.29 | 24 | 672074 | 642 | 70255704 |
Feeling jittery | 14.35 | 10.29 | 170 | 671928 | 11373 | 70244973 |
Respiratory tract malformation | 14.33 | 10.29 | 10 | 672088 | 92 | 70256254 |
Anaemia folate deficiency | 14.31 | 10.29 | 16 | 672082 | 288 | 70256058 |
Bacterial sepsis | 14.31 | 10.29 | 32 | 672066 | 7615 | 70248731 |
Speech disorder | 14.30 | 10.29 | 601 | 671497 | 49979 | 70206367 |
Pleural fibrosis | 14.24 | 10.29 | 11 | 672087 | 4128 | 70252218 |
Erectile dysfunction | 14.23 | 10.29 | 73 | 672025 | 13489 | 70242857 |
Autoimmune hypothyroidism | 14.22 | 10.29 | 14 | 672084 | 216 | 70256130 |
Throat clearing | 14.19 | 10.29 | 42 | 672056 | 1669 | 70254677 |
Pseudomonal sepsis | 14.17 | 10.29 | 19 | 672079 | 5518 | 70250828 |
Supraventricular extrasystoles | 14.16 | 10.29 | 104 | 671994 | 6094 | 70250252 |
Neuromyopathy | 14.15 | 10.29 | 38 | 672060 | 1427 | 70254919 |
Empty sella syndrome | 14.13 | 10.29 | 9 | 672089 | 70 | 70256276 |
Anal prolapse | 14.13 | 10.29 | 9 | 672089 | 70 | 70256276 |
Cortisol decreased | 14.13 | 10.29 | 45 | 672053 | 1862 | 70254484 |
Acute hepatic failure | 14.13 | 10.29 | 181 | 671917 | 27491 | 70228855 |
Hair colour changes | 14.12 | 10.29 | 74 | 672024 | 3849 | 70252497 |
Abnormal weight gain | 14.08 | 10.29 | 51 | 672047 | 2255 | 70254091 |
Blood sodium decreased | 14.02 | 10.29 | 389 | 671709 | 30609 | 70225737 |
Meningitis cryptococcal | 14.00 | 10.29 | 7 | 672091 | 3321 | 70253025 |
Hormone level abnormal | 13.96 | 10.29 | 43 | 672055 | 1747 | 70254599 |
Panic disorder | 13.96 | 10.29 | 59 | 672039 | 2805 | 70253541 |
Urinary incontinence | 13.92 | 10.29 | 463 | 671635 | 37379 | 70218967 |
Tuberculosis | 13.89 | 10.29 | 83 | 672015 | 14765 | 70241581 |
Hyperthermia malignant | 13.85 | 10.29 | 4 | 672094 | 2657 | 70253689 |
Cerebral microangiopathy | 13.82 | 10.29 | 15 | 672083 | 261 | 70256085 |
Varicose vein | 13.79 | 10.29 | 75 | 672023 | 3957 | 70252389 |
Drug level decreased | 13.79 | 10.29 | 67 | 672031 | 12557 | 70243789 |
Wrong patient received product | 13.79 | 10.29 | 81 | 672017 | 4399 | 70251947 |
Paronychia | 13.73 | 10.29 | 29 | 672069 | 7045 | 70249301 |
Intermenstrual bleeding | 13.70 | 10.29 | 91 | 672007 | 5159 | 70251187 |
Needle issue | 13.68 | 10.29 | 161 | 671937 | 10754 | 70245592 |
Blood calcitonin increased | 13.63 | 10.29 | 7 | 672091 | 34 | 70256312 |
Abnormal uterine bleeding | 13.62 | 10.29 | 28 | 672070 | 881 | 70255465 |
Retching | 13.61 | 10.29 | 220 | 671878 | 15759 | 70240587 |
Alcohol abuse | 13.61 | 10.29 | 17 | 672081 | 5090 | 70251256 |
Complications of transplanted kidney | 13.59 | 10.29 | 22 | 672076 | 5912 | 70250434 |
Musculoskeletal discomfort | 13.55 | 10.29 | 241 | 671857 | 17591 | 70238755 |
Pneumonia viral | 13.53 | 10.29 | 129 | 671969 | 8163 | 70248183 |
Dementia | 13.52 | 10.29 | 292 | 671806 | 22073 | 70234273 |
Maternal exposure timing unspecified | 13.49 | 10.29 | 13 | 672085 | 4378 | 70251968 |
Deep brain stimulation | 13.48 | 10.29 | 8 | 672090 | 54 | 70256292 |
Pulmonary valve incompetence | 13.47 | 10.29 | 42 | 672056 | 1718 | 70254628 |
Dyspnoea exertional | 13.47 | 10.29 | 889 | 671209 | 77541 | 70178805 |
Infection reactivation | 13.44 | 10.29 | 3 | 672095 | 2370 | 70253976 |
COVID-19 pneumonia | 13.44 | 10.29 | 138 | 671960 | 21831 | 70234515 |
Frontotemporal dementia | 13.40 | 10.29 | 22 | 672076 | 580 | 70255766 |
Blood potassium decreased | 13.38 | 10.29 | 510 | 671588 | 41911 | 70214435 |
Bundle branch block left | 13.30 | 10.29 | 154 | 671944 | 10245 | 70246101 |
Bronchitis | 13.29 | 10.29 | 1287 | 670811 | 115956 | 70140390 |
Pituitary cyst | 13.28 | 10.29 | 5 | 672093 | 9 | 70256337 |
Cough | 13.28 | 10.29 | 3373 | 668725 | 322004 | 69934342 |
Stress fracture | 13.27 | 10.29 | 98 | 672000 | 5752 | 70250594 |
Acute lung injury | 13.26 | 10.29 | 5 | 672093 | 2804 | 70253542 |
Skin irritation | 13.24 | 10.29 | 148 | 671950 | 9761 | 70246585 |
Pulmonary alveolar haemorrhage | 13.17 | 10.29 | 52 | 672046 | 10317 | 70246029 |
Immune effector cell-associated neurotoxicity syndrome | 13.15 | 10.29 | 11 | 672087 | 3967 | 70252379 |
Gingival disorder | 13.14 | 10.29 | 66 | 672032 | 3376 | 70252970 |
Immediate post-injection reaction | 13.09 | 10.29 | 16 | 672082 | 318 | 70256028 |
Mineral deficiency | 13.01 | 10.29 | 7 | 672091 | 38 | 70256308 |
Red blood cell sedimentation rate increased | 13.01 | 10.29 | 273 | 671825 | 38369 | 70217977 |
Cytomegalovirus test positive | 13.01 | 10.29 | 20 | 672078 | 5488 | 70250858 |
Appendicitis | 12.93 | 10.29 | 99 | 671999 | 16634 | 70239712 |
Piloerection | 12.93 | 10.29 | 19 | 672079 | 454 | 70255892 |
Hyponatraemic seizure | 12.89 | 10.29 | 20 | 672078 | 502 | 70255844 |
Basedow's disease | 12.88 | 10.29 | 14 | 672084 | 244 | 70256102 |
Forced vital capacity decreased | 12.88 | 10.29 | 39 | 672059 | 1570 | 70254776 |
Inflammation | 12.74 | 10.29 | 612 | 671486 | 78053 | 70178293 |
Pneumonia aspiration | 12.73 | 10.29 | 472 | 671626 | 61817 | 70194529 |
Body height increased | 12.66 | 10.29 | 10 | 672088 | 113 | 70256233 |
Tinnitus | 12.65 | 10.29 | 440 | 671658 | 35736 | 70220610 |
Bone loss | 12.62 | 10.29 | 51 | 672047 | 2376 | 70253970 |
Chromaturia | 12.61 | 10.29 | 302 | 671796 | 23226 | 70233120 |
Tongue haematoma | 12.59 | 10.29 | 13 | 672085 | 213 | 70256133 |
Miosis | 12.58 | 10.29 | 80 | 672018 | 14021 | 70242325 |
Spondylolisthesis | 12.54 | 10.29 | 58 | 672040 | 2868 | 70253478 |
Polyhydramnios | 12.52 | 10.29 | 37 | 672061 | 1469 | 70254877 |
Cholecystitis chronic | 12.51 | 10.29 | 140 | 671958 | 9236 | 70247110 |
Sneezing | 12.49 | 10.29 | 228 | 671870 | 16723 | 70239623 |
Dilatation atrial | 12.47 | 10.29 | 66 | 672032 | 3446 | 70252900 |
Sexual dysfunction | 12.47 | 10.29 | 28 | 672070 | 6653 | 70249693 |
Laryngeal injury | 12.46 | 10.29 | 4 | 672094 | 3 | 70256343 |
Ecchymosis | 12.46 | 10.29 | 198 | 671900 | 14134 | 70242212 |
Orthostatic intolerance | 12.46 | 10.29 | 41 | 672057 | 1726 | 70254620 |
Eye disorder | 12.45 | 10.29 | 271 | 671827 | 20514 | 70235832 |
Product dispensing error | 12.45 | 10.29 | 171 | 671927 | 11837 | 70244509 |
Coronary arterial stent insertion | 12.41 | 10.29 | 23 | 672075 | 5864 | 70250482 |
Gastrointestinal tract mucosal pigmentation | 12.40 | 10.29 | 28 | 672070 | 941 | 70255405 |
Brain natriuretic peptide abnormal | 12.40 | 10.29 | 23 | 672075 | 670 | 70255676 |
Therapeutic product effect variable | 12.35 | 10.29 | 40 | 672058 | 1670 | 70254676 |
Therapeutic product effect increased | 12.35 | 10.29 | 35 | 672063 | 1357 | 70254989 |
Adverse drug reaction | 12.34 | 10.29 | 398 | 671700 | 52946 | 70203400 |
Lipoma excision | 12.34 | 10.29 | 5 | 672093 | 12 | 70256334 |
Madarosis | 12.32 | 10.29 | 52 | 672046 | 2471 | 70253875 |
Rotator cuff repair | 12.27 | 10.29 | 39 | 672059 | 1612 | 70254734 |
Secondary immunodeficiency | 12.27 | 10.29 | 6 | 672092 | 2883 | 70253463 |
Sinus disorder | 12.27 | 10.29 | 250 | 671848 | 18709 | 70237637 |
Nerve compression | 12.26 | 10.29 | 125 | 671973 | 8053 | 70248293 |
Vulvovaginal discomfort | 12.21 | 10.29 | 39 | 672059 | 1616 | 70254730 |
Bacterial infection | 12.19 | 10.29 | 177 | 671921 | 26315 | 70230031 |
Angina pectoris | 12.16 | 10.29 | 568 | 671530 | 47815 | 70208531 |
Hypoglycaemic unconsciousness | 12.13 | 10.29 | 31 | 672067 | 1129 | 70255217 |
Schizophrenia | 12.13 | 10.29 | 101 | 671997 | 16667 | 70239679 |
Germ cell cancer | 12.08 | 10.29 | 11 | 672087 | 153 | 70256193 |
Mean cell haemoglobin concentration increased | 12.03 | 10.29 | 25 | 672073 | 793 | 70255553 |
Nephrectomy | 11.98 | 10.29 | 41 | 672057 | 1762 | 70254584 |
Basal cell carcinoma | 11.97 | 10.29 | 236 | 671862 | 33462 | 70222884 |
Rectal polyp | 11.96 | 10.29 | 36 | 672062 | 1444 | 70254902 |
Sprue-like enteropathy | 11.96 | 10.29 | 30 | 672068 | 1080 | 70255266 |
Polyp | 11.93 | 10.29 | 112 | 671986 | 7058 | 70249288 |
Groin pain | 11.88 | 10.29 | 170 | 671928 | 11872 | 70244474 |
Gastrointestinal tract irritation | 11.84 | 10.29 | 20 | 672078 | 540 | 70255806 |
Thyroid mass | 11.83 | 10.29 | 65 | 672033 | 3443 | 70252903 |
Tracheal fistula | 11.78 | 10.29 | 10 | 672088 | 126 | 70256220 |
Oesophageal achalasia | 11.75 | 10.29 | 23 | 672075 | 698 | 70255648 |
Upper respiratory tract inflammation | 11.73 | 10.29 | 12 | 672086 | 3930 | 70252416 |
Starvation ketoacidosis | 11.71 | 10.29 | 10 | 672088 | 127 | 70256219 |
Emotional distress | 11.70 | 10.29 | 447 | 671651 | 36741 | 70219605 |
Urine sodium decreased | 11.70 | 10.29 | 14 | 672084 | 272 | 70256074 |
Recalled product | 11.70 | 10.29 | 27 | 672071 | 921 | 70255425 |
Vomiting | 11.69 | 10.29 | 5985 | 666113 | 587126 | 69669220 |
Senile osteoporosis | 11.67 | 10.29 | 9 | 672089 | 98 | 70256248 |
Transplant failure | 11.66 | 10.29 | 13 | 672085 | 4094 | 70252252 |
Neutrophil count increased | 11.65 | 10.29 | 181 | 671917 | 26614 | 70229732 |
Fear of injection | 11.62 | 10.29 | 29 | 672069 | 6643 | 70249703 |
Superficial vein prominence | 11.61 | 10.29 | 8 | 672090 | 72 | 70256274 |
Emotional disorder | 11.61 | 10.29 | 183 | 671915 | 13043 | 70243303 |
Expired product administered | 11.60 | 10.29 | 102 | 671996 | 6311 | 70250035 |
Affect lability | 11.56 | 10.29 | 147 | 671951 | 9999 | 70246347 |
Congenital central nervous system anomaly | 11.55 | 10.29 | 5 | 672093 | 15 | 70256331 |
Metastases to neck | 11.55 | 10.29 | 6 | 672092 | 30 | 70256316 |
Ocular discomfort | 11.51 | 10.29 | 76 | 672022 | 4301 | 70252045 |
Diffuse alveolar damage | 11.49 | 10.29 | 9 | 672089 | 3354 | 70252992 |
Candida infection | 11.48 | 10.29 | 244 | 671854 | 34229 | 70222117 |
Gastric pH increased | 11.47 | 10.29 | 7 | 672091 | 50 | 70256296 |
Oesophageal disorder | 11.47 | 10.29 | 51 | 672047 | 2479 | 70253867 |
Supraventricular tachyarrhythmia | 11.44 | 10.29 | 9 | 672089 | 101 | 70256245 |
Hypotensive transfusion reaction | 11.43 | 10.29 | 8 | 672090 | 74 | 70256272 |
Suspected suicide | 11.41 | 10.29 | 44 | 672054 | 8790 | 70247556 |
Disturbance in social behaviour | 11.41 | 10.29 | 13 | 672085 | 4054 | 70252292 |
Incorrect dose administered | 11.41 | 10.29 | 756 | 671342 | 65963 | 70190383 |
Blood urea nitrogen/creatinine ratio increased | 11.39 | 10.29 | 25 | 672073 | 824 | 70255522 |
Mydriasis | 11.37 | 10.29 | 98 | 672000 | 16055 | 70240291 |
Lichen nitidus | 11.34 | 10.29 | 8 | 672090 | 75 | 70256271 |
Anaemia postoperative | 11.34 | 10.29 | 40 | 672058 | 1745 | 70254601 |
Application site vesicles | 11.32 | 10.29 | 33 | 672065 | 1300 | 70255046 |
Joint laxity | 11.32 | 10.29 | 4 | 672094 | 2335 | 70254011 |
Delirium | 11.21 | 10.29 | 585 | 671513 | 74029 | 70182317 |
Tonsillar disorder | 11.20 | 10.29 | 29 | 672069 | 1065 | 70255281 |
Rectocele | 11.18 | 10.29 | 20 | 672078 | 566 | 70255780 |
Lactation disorder | 11.18 | 10.29 | 12 | 672086 | 206 | 70256140 |
Angle closure glaucoma | 11.11 | 10.29 | 54 | 672044 | 2725 | 70253621 |
Fanconi syndrome acquired | 11.11 | 10.29 | 5 | 672093 | 2522 | 70253824 |
Chondromalacia | 11.11 | 10.29 | 11 | 672087 | 171 | 70256175 |
Chronic fatigue syndrome | 11.11 | 10.29 | 31 | 672067 | 1191 | 70255155 |
Mycobacterial infection | 11.10 | 10.29 | 10 | 672088 | 3478 | 70252868 |
Intervertebral disc disorder | 11.09 | 10.29 | 78 | 672020 | 4507 | 70251839 |
Generalised tonic-clonic seizure | 11.09 | 10.29 | 305 | 671793 | 41356 | 70214990 |
Temperature intolerance | 11.08 | 10.29 | 129 | 671969 | 8594 | 70247752 |
Cardiac pacemaker insertion | 11.08 | 10.29 | 88 | 672010 | 5284 | 70251062 |
Fractured coccyx | 11.03 | 10.29 | 27 | 672071 | 957 | 70255389 |
Application site pruritus | 11.01 | 10.29 | 65 | 672033 | 3536 | 70252810 |
Hypothyroidic goitre | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Invasive papillary breast carcinoma | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Body height abnormal | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Thyroid pain | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Tri-iodothyronine free | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Clear cell endometrial carcinoma | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Synovial cyst removal | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Primary hyperthyroidism | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Blood proinsulin increased | 11.01 | 10.29 | 3 | 672095 | 0 | 70256346 |
Antinuclear antibody positive | 11.00 | 10.29 | 106 | 671992 | 6727 | 70249619 |
Pituitary haemorrhage | 10.98 | 10.29 | 14 | 672084 | 291 | 70256055 |
Skin ulcer | 10.95 | 10.29 | 360 | 671738 | 47785 | 70208561 |
Eructation | 10.95 | 10.29 | 141 | 671957 | 9619 | 70246727 |
Gene mutation | 10.94 | 10.29 | 4 | 672094 | 2287 | 70254059 |
Thyroglobulin increased | 10.93 | 10.29 | 7 | 672091 | 55 | 70256291 |
Thyroid neoplasm | 10.93 | 10.29 | 56 | 672042 | 2887 | 70253459 |
Immunisation reaction | 10.91 | 10.29 | 12 | 672086 | 212 | 70256134 |
Vulvovaginal mycotic infection | 10.89 | 10.29 | 70 | 672028 | 3925 | 70252421 |
Pain threshold decreased | 10.88 | 10.29 | 5 | 672093 | 18 | 70256328 |
Lethargy | 10.86 | 10.29 | 841 | 671257 | 74409 | 70181937 |
Lens disorder | 10.82 | 10.29 | 10 | 672088 | 142 | 70256204 |
Sensory level abnormal | 10.82 | 10.29 | 10 | 672088 | 142 | 70256204 |
Neck pain | 10.82 | 10.29 | 752 | 671346 | 65905 | 70190441 |
Muscle fatigue | 10.81 | 10.29 | 60 | 672038 | 3191 | 70253155 |
Prostate cancer metastatic | 10.80 | 10.29 | 13 | 672085 | 3956 | 70252390 |
Hair texture abnormal | 10.78 | 10.29 | 59 | 672039 | 3121 | 70253225 |
Coordination abnormal | 10.78 | 10.29 | 213 | 671885 | 15853 | 70240493 |
Vertigo positional | 10.77 | 10.29 | 57 | 672041 | 2976 | 70253370 |
Hair disorder | 10.77 | 10.29 | 27 | 672071 | 972 | 70255374 |
Embedded device | 10.75 | 10.29 | 55 | 672043 | 2834 | 70253512 |
Pseudomembranous colitis | 10.74 | 10.29 | 20 | 672078 | 5091 | 70251255 |
Acetabulum fracture | 10.71 | 10.29 | 19 | 672079 | 534 | 70255812 |
Neoplasm recurrence | 10.71 | 10.29 | 69 | 672029 | 3872 | 70252474 |
Metastases to pituitary gland | 10.68 | 10.29 | 5 | 672093 | 19 | 70256327 |
Vitamin D deficiency | 10.67 | 10.29 | 172 | 671926 | 12315 | 70244031 |
Oropharyngeal swelling | 10.64 | 10.29 | 31 | 672067 | 1221 | 70255125 |
Retroplacental haematoma | 10.63 | 10.29 | 9 | 672089 | 113 | 70256233 |
Pneumonia pseudomonal | 10.62 | 10.29 | 21 | 672077 | 5225 | 70251121 |
Product packaging confusion | 10.61 | 10.29 | 12 | 672086 | 219 | 70256127 |
Endometrial thickening | 10.58 | 10.29 | 13 | 672085 | 260 | 70256086 |
Disseminated tuberculosis | 10.56 | 10.29 | 14 | 672084 | 4086 | 70252260 |
Ear discomfort | 10.54 | 10.29 | 115 | 671983 | 7539 | 70248807 |
Distributive shock | 10.53 | 10.29 | 4 | 672094 | 2233 | 70254113 |
Painful respiration | 10.53 | 10.29 | 59 | 672039 | 3149 | 70253197 |
Carcinoid tumour of the stomach | 10.52 | 10.29 | 11 | 672087 | 183 | 70256163 |
Pulmonary haemorrhage | 10.52 | 10.29 | 81 | 672017 | 13592 | 70242754 |
Post procedural hypothyroidism | 10.50 | 10.29 | 9 | 672089 | 115 | 70256231 |
Superficial injury of eye | 10.49 | 10.29 | 10 | 672088 | 148 | 70256198 |
Onychoclasis | 10.47 | 10.29 | 82 | 672016 | 4902 | 70251444 |
Chest discomfort | 10.47 | 10.29 | 1339 | 670759 | 123042 | 70133304 |
Colitis ulcerative | 10.47 | 10.29 | 243 | 671855 | 33680 | 70222666 |
Myelopathy | 10.46 | 10.29 | 15 | 672083 | 4236 | 70252110 |
Dislocation of vertebra | 10.46 | 10.29 | 19 | 672079 | 4881 | 70251465 |
Progressive multifocal leukoencephalopathy | 10.44 | 10.29 | 124 | 671974 | 19090 | 70237256 |
Aortic intramural haematoma | 10.44 | 10.29 | 9 | 672089 | 116 | 70256230 |
Thirst | 10.43 | 10.29 | 196 | 671902 | 14453 | 70241893 |
Pharyngitis | 10.43 | 10.29 | 133 | 671965 | 20218 | 70236128 |
Tooth disorder | 10.43 | 10.29 | 299 | 671799 | 23639 | 70232707 |
Barrett's oesophagus | 10.40 | 10.29 | 23 | 672075 | 762 | 70255584 |
Sputum increased | 10.39 | 10.29 | 14 | 672084 | 4058 | 70252288 |
Toxic anterior segment syndrome | 10.38 | 10.29 | 6 | 672092 | 2624 | 70253722 |
Seizure | 10.37 | 10.29 | 1503 | 670595 | 176459 | 70079887 |
Nasal obstruction | 10.33 | 10.29 | 36 | 672062 | 1561 | 70254785 |
Sinusitis | 10.32 | 10.29 | 1425 | 670673 | 167770 | 70088576 |
Bronchiectasis | 10.31 | 10.29 | 100 | 671998 | 15997 | 70240349 |
Limb discomfort | 10.31 | 10.29 | 361 | 671737 | 29344 | 70227002 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Small for dates baby | 30.84 | 17.65 | 147 | 2165 | 2662 | 84818 |
Premature baby | 28.90 | 17.65 | 36 | 2276 | 3892 | 83588 |
Atrial septal defect | 19.51 | 17.65 | 141 | 2171 | 2978 | 84502 |
Source | Code | Description |
---|---|---|
ATC | H03AA01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS THYROID THERAPY THYROID PREPARATIONS Thyroid hormones |
FDA CS | M0021504 | Thyroxine |
FDA EPC | N0000175945 | l-Thyroxine |
CHEBI has role | CHEBI:50671 | antithyroid drugs |
CHEBI has role | CHEBI:60311 | thyroid hormones |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:52290 | mitogens |
CHEBI has role | CHEBI:53000 | epitope role |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Goiter | indication | 3716002 | DOID:12176 |
Hashimoto thyroiditis | indication | 21983002 | |
Hypothyroidism | indication | 40930008 | DOID:1459 |
Myxedema | indication | 43153006 | DOID:11634 |
Hyperlipidemia | indication | 55822004 | DOID:1168 |
Congenital hypothyroidism | indication | 190268003 | DOID:0050328 |
Malignant tumor of thyroid gland | indication | 363478007 | DOID:1781 |
Diagnostic Test for Thyroid Dysfunction | indication | ||
Myxedema coma | off-label use | 21263006 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Thyrotoxic crisis | contraindication | 29028009 | DOID:12837 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Angina pectoris | contraindication | 194828000 | |
Osteopenia | contraindication | 312894000 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Disorder of coronary artery | contraindication | 414024009 |
Species | Use | Relation |
---|---|---|
Dogs | Replacement therapy for diminished thyroid function | Indication |
Product | Applicant | Ingredients |
---|---|---|
Thyro-Tabs Canine | Lloyd Inc. | 1 |
ThyroKare | Neogen Corp. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.08 | acidic |
pKa2 | 6.63 | acidic |
pKa3 | 8.6 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.025MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.05MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.075MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.088MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.112MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.125MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.137MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.15MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.175MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.1MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.2MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | DISCN | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thyroid hormone receptor alpha | Nuclear hormone receptor | AGONIST | EC50 | 7.72 | CHEMBL | IUPHAR | |||
Thyroid hormone receptor beta | Nuclear hormone receptor | AGONIST | IC50 | 8.52 | IUPHAR | CHEMBL | |||
Transthyretin | Secreted | IC50 | 4.98 | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | Kd | 6.40 | CHEMBL | |||||
Retinoic acid receptor RXR-alpha | Nuclear hormone receptor | Kd | 6.03 | CHEMBL | |||||
Bile acid receptor | Nuclear hormone receptor | IC50 | 5.10 | CHEMBL | |||||
THAP domain-containing protein 1 | Unclassified | WOMBAT-PK | |||||||
Macrophage migration inhibitory factor | Unclassified | IC50 | 4.80 | CHEMBL | |||||
Malate dehydrogenase, mitochondrial | Enzyme | IC50 | 4.36 | CHEMBL | |||||
Thyroid hormone receptor beta | Transcription factor | IC50 | 7.46 | CHEMBL |
ID | Source |
---|---|
4017826 | VUID |
N0000179290 | NUI |
D01010 | KEGG_DRUG |
55-03-8 | SECONDARY_CAS_RN |
6106-07-6 | SECONDARY_CAS_RN |
4017826 | VANDF |
4022126 | VANDF |
CHEBI:18332 | CHEBI |
CHEMBL1624 | ChEMBL_ID |
CHEMBL2103741 | ChEMBL_ID |
CHEMBL559 | ChEMBL_ID |
CHEMBL42115 | ChEMBL_ID |
DB00451 | DRUGBANK_ID |
Q51BO43MG4 | UNII |
10582 | RXNORM |
1842 | MMSL |
4976 | MMSL |
d00278 | MMSL |
002132 | NDDF |
004881 | NDDF |
005896 | NDDF |
126202002 | SNOMEDCT_US |
38076006 | SNOMEDCT_US |
710809001 | SNOMEDCT_US |
73187006 | SNOMEDCT_US |
768532006 | SNOMEDCT_US |
783637002 | SNOMEDCT_US |
C0040165 | UMLSCUI |
D013974 | MESH_DESCRIPTOR_UI |
T44 | PDB_CHEM_ID |
453 | INN_ID |
5819 | PUBCHEM_CID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-3727 | TABLET | 137 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-3727 | TABLET | 137 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-4341 | TABLET | 25 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-4341 | TABLET | 25 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-4552 | TABLET | 50 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-4552 | TABLET | 50 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-5182 | TABLET | 75 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-5182 | TABLET | 75 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-6594 | TABLET | 88 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-6594 | TABLET | 88 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-6624 | TABLET | 100 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-6624 | TABLET | 100 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7068 | TABLET | 125 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7068 | TABLET | 125 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7069 | TABLET | 150 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7069 | TABLET | 150 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7070 | TABLET | 175 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7070 | TABLET | 175 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7148 | TABLET | 200 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7148 | TABLET | 200 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7149 | TABLET | 300 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7149 | TABLET | 300 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-9296 | TABLET | 112 ug | ORAL | NDA | 26 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-9296 | TABLET | 112 ug | ORAL | NDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1800 | TABLET | 25 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1803 | TABLET | 50 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1805 | TABLET | 75 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1807 | TABLET | 88 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1809 | TABLET | 100 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1811 | TABLET | 112 ug | ORAL | ANDA | 26 sections |