levothyroxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2646 51-48-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levothyroxine sodium anhydrous
  • levothyroxine sodium pentahydrate
  • L-Thyroxine
  • thyroxin sodium
  • thyroxine sodium
  • levothyroxine sodium
  • tetraiodothyronine
  • thyroxine
  • levothyroxine
  • levothyroxin natrium
  • T4
  • levothyroxine sodium hydrate
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
  • Molecular weight: 776.87
  • Formula: C15H11I4NO4
  • CLOGP: 3.21
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 3
  • TPSA: 92.78
  • ALOGS: -4.94
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 mg O
0.15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 64 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.204 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 9.290 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 7.586 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.629 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.380 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 0.420 % High 1
herg hERG pIC50 5.102 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.958 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 6.295 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.570 % High 1
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K1,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 74
kinase-selectivity-class ACVR2A,ACVR2B,AURKA,AURKC,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK16,CDK2,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT4,GRK2,GSK3A,GSK3B,JAK2,MAP2K6,MAP3K2,MAP3K21,MAP4K1,MAPK1,MAPK7,PDK1,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK10,STK33,SYK,TEK,TGFBR1,TTK,ULK1 43
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 26.002 High 1
mh-clint Mouse hepatocyte intrinsic clearance 8.872 High 1
mppb Mouse plasma protein binding (% unbound) 0.380 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 8.531 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 0.260 % High 1
rh-clint Rat hepatocyte intrinsic clearance 16.331 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 10.240 % High 1
rppb Rat plasma protein binding (% unbound) 0.300 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 1.585 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 23, 2020 PMDA Aska Pharmaceutical Co., Ltd
Aug. 21, 2000 FDA STEVENS J

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1902.30 9.72 356 835487 326508 89466096
Systemic lupus erythematosus 1660.00 9.72 631 835212 361265 89431339
Glossodynia 1573.75 9.72 504 835339 321275 89471329
Hand deformity 1373.39 9.72 508 835335 295854 89496750
Synovitis 1301.61 9.72 710 835133 329042 89463562
Contraindicated product administered 1194.28 9.72 738 835105 319401 89473203
Anti-cyclic citrullinated peptide antibody positive 1186.80 9.72 353 835490 236080 89556524
Infusion related reaction 1152.59 9.72 1287 834556 415493 89377111
Pericarditis 1134.25 9.72 536 835307 269615 89522989
Wound 1112.79 9.72 711 835132 302269 89490335
Duodenal ulcer perforation 1044.16 9.72 368 835475 220920 89571684
Blood thyroid stimulating hormone increased 1021.16 9.72 772 835071 8383 89784221
Helicobacter infection 977.18 9.72 434 835409 226416 89566188
Arthropathy 970.24 9.72 1170 834673 365072 89427532
Treatment failure 935.13 9.72 855 834988 303073 89489531
Folliculitis 910.45 9.72 372 835471 203981 89588623
Drug intolerance 847.29 9.72 1788 834055 445803 89346801
Hypothyroidism 845.38 9.72 1651 834192 51476 89741128
Hepatic enzyme increased 829.71 9.72 1277 834566 359459 89433145
Drug ineffective 767.71 9.72 8630 827213 1375668 88416936
Swelling 762.44 9.72 1711 834132 417347 89375257
Muscle injury 760.62 9.72 338 835505 176316 89616288
Maternal exposure during pregnancy 759.78 9.72 1348 834495 358715 89433889
Irritable bowel syndrome 673.73 9.72 554 835289 206894 89585710
Rheumatoid factor positive 654.60 9.72 385 835458 171265 89621339
Impaired healing 641.46 9.72 728 835115 233471 89559133
Therapeutic product effect decreased 626.15 9.72 995 834848 276576 89516028
Joint swelling 620.16 9.72 2464 833379 500836 89291768
Discomfort 593.09 9.72 1011 834832 273324 89519280
Abdominal discomfort 574.04 9.72 2359 833484 474969 89317635
Lower respiratory tract infection 570.57 9.72 893 834950 249766 89542838
Fall 566.89 9.72 6862 828981 474948 89317656
Rheumatic fever 555.36 9.72 364 835479 152757 89639847
Hyperthyroidism 525.40 9.72 742 835101 17568 89775036
Hypersensitivity 512.35 9.72 2303 833540 452374 89340230
Blister 489.19 9.72 1010 834833 253988 89538616
Off label use 480.89 9.72 7219 828624 1095033 88697571
Ill-defined disorder 471.95 9.72 607 835236 184284 89608320
Alopecia 467.67 9.72 2666 833177 492405 89300199
Sleep disorder due to general medical condition, insomnia type 461.19 9.72 310 835533 128384 89664220
Psoriatic arthropathy 438.27 9.72 904 834939 227431 89565173
Drug hypersensitivity 431.14 9.72 2509 833334 461100 89331504
Liver injury 427.09 9.72 568 835275 169999 89622605
Type 2 diabetes mellitus 426.41 9.72 763 835080 202481 89590123
Palpitations 410.20 9.72 2406 833437 134322 89658282
Facet joint syndrome 409.82 9.72 197 835646 98192 89694412
Stomatitis 409.24 9.72 1239 834604 273459 89519145
Blood thyroid stimulating hormone abnormal 395.79 9.72 192 835651 832 89791772
Breast cancer stage III 375.46 9.72 154 835689 84293 89708311
Hyponatraemia 357.05 9.72 2281 833562 131257 89661347
Blood thyroid stimulating hormone decreased 356.54 9.72 346 835497 5394 89787210
Exposure during pregnancy 351.01 9.72 1081 834762 237329 89555275
Hypercholesterolaemia 349.59 9.72 252 835591 100640 89691964
Swollen joint count increased 345.02 9.72 310 835533 110896 89681708
Joint range of motion decreased 322.23 9.72 469 835374 135174 89657430
Product use issue 313.69 9.72 1772 834071 328147 89464457
Feeling abnormal 310.76 9.72 2619 833224 164616 89627988
Infection 309.09 9.72 2012 833831 360082 89432522
Myalgia 307.84 9.72 2709 833134 172416 89620188
Injury 303.30 9.72 877 834966 196472 89596132
Wound infection 286.52 9.72 335 835508 106067 89686537
Atrial fibrillation 281.17 9.72 2153 833690 131458 89661146
Lip dry 270.61 9.72 319 835524 100636 89691968
Product substitution issue 260.52 9.72 538 835305 17470 89775134
C-reactive protein abnormal 255.99 9.72 491 835352 126938 89665666
Blepharospasm 253.21 9.72 97 835746 55348 89737256
Asthenia 252.57 9.72 6576 829267 527175 89265429
Musculoskeletal stiffness 249.78 9.72 1654 834189 294878 89497726
Thyroid function test abnormal 248.79 9.72 241 835602 3748 89788856
Constipation 244.46 9.72 3787 832056 276608 89515996
Dislocation of vertebra 244.07 9.72 105 835738 55863 89736741
Balance disorder 243.45 9.72 1632 834211 95448 89697156
Onychomadesis 241.16 9.72 63 835780 45935 89746669
Gastrointestinal disorder 236.73 9.72 1392 834451 255295 89537309
Bursitis 236.12 9.72 541 835302 131113 89661491
Grip strength decreased 232.97 9.72 307 835536 92269 89700335
Fibromyalgia 232.37 9.72 1044 834799 205225 89587379
Peripheral venous disease 229.43 9.72 261 835582 83660 89708944
Blood thyroid stimulating hormone normal 223.83 9.72 71 835772 52 89792552
Myelosuppression 219.06 9.72 110 835733 53481 89739123
Blood pressure increased 218.37 9.72 2779 833064 194438 89598166
Cognitive disorder 216.28 9.72 1234 834609 68173 89724431
Intentional product use issue 211.97 9.72 1154 834689 215738 89576866
Thyroid disorder 211.43 9.72 491 835352 17294 89775310
Inflammation 210.23 9.72 889 834954 177703 89614901
Prescribed overdose 208.70 9.72 362 835481 97263 89695341
Syncope 204.26 9.72 1995 833848 130668 89661936
Dehydration 203.97 9.72 2713 833130 191734 89600870
Orthostatic hypotension 201.12 9.72 842 835001 40985 89751619
Product use in unapproved indication 200.72 9.72 2056 833787 334180 89458424
Vertigo 198.08 9.72 1211 834632 68600 89724004
Product prescribing error 192.18 9.72 664 835179 29481 89763123
Adjustment disorder with depressed mood 191.10 9.72 146 835697 56607 89735997
Tremor 190.70 9.72 2207 833636 150966 89641638
Dizziness 186.49 9.72 6914 828929 582370 89210234
C-reactive protein increased 186.22 9.72 949 834894 180440 89612164
Wheezing 184.20 9.72 1361 834482 236719 89555885
Bone erosion 177.76 9.72 137 835706 52884 89739720
Nausea 175.76 9.72 12182 823661 1098134 88694470
Nail disorder 175.71 9.72 171 835672 58896 89733708
Vision blurred 172.42 9.72 1664 834179 108629 89683975
Dysphagia 171.14 9.72 1685 834158 110593 89682011
Retinitis 169.53 9.72 71 835772 38387 89754217
Diarrhoea 166.52 9.72 10405 825438 928785 88863819
Rash 165.36 9.72 5846 829997 790254 89002350
Blood cholesterol increased 164.80 9.72 1181 834662 206831 89585773
Schizoaffective disorder 163.34 9.72 219 835624 4928 89787676
Rheumatoid arthritis 163.25 9.72 2357 833486 360257 89432347
Onychomycosis 160.00 9.72 72 835771 37304 89755300
Blood glucose increased 159.38 9.72 1458 834385 93788 89698816
Acute kidney injury 158.48 9.72 3972 831871 316415 89476189
Urinary tract infection 155.01 9.72 3802 832041 301830 89490774
Sleep disorder 153.66 9.72 1131 834712 196899 89595705
Blood calcium decreased 150.94 9.72 615 835228 29567 89763037
Disturbance in attention 147.70 9.72 839 835004 46270 89746334
Dysgeusia 146.10 9.72 907 834936 51653 89740951
Live birth 145.96 9.72 320 835523 78787 89713817
Nasopharyngitis 142.43 9.72 2771 833072 404333 89388271
Back injury 142.15 9.72 132 835711 46490 89746114
Transient ischaemic attack 142.04 9.72 779 835064 42397 89750207
Obesity 140.28 9.72 500 835343 105007 89687597
Lupus vulgaris 139.25 9.72 126 835717 44933 89747671
Adrenocortical insufficiency acute 136.29 9.72 143 835700 2458 89790146
Hip arthroplasty 134.33 9.72 316 835527 75892 89716712
Adverse event 134.15 9.72 591 835252 116827 89675777
Gait inability 133.99 9.72 796 835047 145660 89646944
Dry skin 133.84 9.72 1321 834522 86752 89705852
Finger deformity 132.25 9.72 69 835774 32828 89759776
Taste disorder 131.73 9.72 228 835615 61318 89731286
Drug interaction 130.99 9.72 3408 832435 273045 89519559
Product label confusion 130.35 9.72 26 835817 22824 89769780
Creatinine renal clearance decreased 127.25 9.72 424 835419 18475 89774129
Therapeutic product effect incomplete 125.99 9.72 1161 834682 192735 89599869
Therapy non-responder 125.58 9.72 742 835101 135962 89656642
Cerebrovascular accident 125.11 9.72 1713 834130 121820 89670784
Sedation complication 123.90 9.72 391 835452 16553 89776051
Angina pectoris 123.14 9.72 698 835145 38462 89754142
Hypoglycaemia 120.82 9.72 1077 834766 68771 89723833
Hot flush 119.21 9.72 948 834895 58540 89734064
Mobility decreased 119.09 9.72 1612 834231 249122 89543482
Hypotension 116.64 9.72 3874 831969 321523 89471081
Condition aggravated 115.85 9.72 4407 831436 591138 89201466
X-ray abnormal 114.92 9.72 150 835693 45274 89747330
Pulmonary fibrosis 114.56 9.72 555 835288 106948 89685656
Night sweats 113.52 9.72 708 835135 128058 89664546
Pain 111.05 9.72 7805 828038 988536 88804068
Full blood count abnormal 110.94 9.72 646 835197 35951 89756653
Product dose omission issue 107.95 9.72 3486 832357 288201 89504403
Deep vein thrombosis postoperative 107.73 9.72 316 835527 70493 89722111
Anaemia 105.75 9.72 4116 831727 348686 89443918
Epilepsy 105.70 9.72 395 835448 81811 89710793
Anxiety 104.70 9.72 3663 832180 306109 89486495
Breast cancer stage II 104.27 9.72 103 835740 35231 89757373
Pulmonary embolism 103.05 9.72 1738 834105 129082 89663522
Drug tolerance decreased 102.73 9.72 87 835756 32043 89760561
Coeliac disease 102.25 9.72 158 835685 44452 89748152
Lupus-like syndrome 101.78 9.72 184 835659 48662 89743942
Bone pain 101.24 9.72 944 834899 61039 89731565
Product complaint 100.99 9.72 314 835529 13186 89779418
Bradycardia 100.26 9.72 1199 834644 82648 89709956
Chest discomfort 99.95 9.72 1813 834030 136552 89656052
Autoimmune disorder 99.82 9.72 367 835476 76377 89716227
Peripheral swelling 99.69 9.72 2974 832869 410132 89382472
Eye irritation 99.28 9.72 594 835249 33384 89759220
Drug resistance 99.14 9.72 81 835762 30368 89762236
Back pain 98.51 9.72 3715 832128 313460 89479144
Somnolence 97.97 9.72 2574 833269 206510 89586094
Hyperhidrosis 97.05 9.72 1782 834061 134523 89658081
Prescribed underdose 96.76 9.72 360 835483 74659 89717945
Sensitisation 96.60 9.72 153 835690 4022 89788582
Foot deformity 96.08 9.72 259 835584 59392 89733212
Tinnitus 95.94 9.72 704 835139 42398 89750206
Seronegative arthritis 95.53 9.72 25 835818 18209 89774395
Therapeutic response unexpected 94.88 9.72 427 835416 21453 89771151
Fatigue 94.65 9.72 12084 823759 1141939 88650665
Arrhythmia 93.98 9.72 691 835152 41641 89750963
Autoimmune thyroiditis 92.32 9.72 182 835661 5711 89786893
Cough 91.71 9.72 4221 831622 364741 89427863
Influenza like illness 90.87 9.72 1140 834703 79471 89713133
Red blood cell sedimentation rate increased 88.82 9.72 425 835418 82170 89710434
Nervousness 88.04 9.72 577 835266 33479 89759125
Knee arthroplasty 87.72 9.72 431 835412 82751 89709853
Cytomegalovirus infection 87.57 9.72 70 835773 26532 89766072
Thyroid cancer 86.53 9.72 184 835659 6100 89786504
Exostosis 85.35 9.72 231 835612 52903 89739701
Febrile neutropenia 84.50 9.72 993 834850 157356 89635248
Cardiac disorder 83.96 9.72 848 834995 56024 89736580
Red blood cell sedimentation rate abnormal 83.11 9.72 61 835782 24143 89768461
Cataract 81.04 9.72 1019 834824 71073 89721531
Headache 80.59 9.72 9110 826733 853636 88938968
Liver function test increased 79.82 9.72 457 835386 84398 89708206
Thyroidectomy 79.10 9.72 78 835765 1241 89791363
Gastritis 78.58 9.72 656 835187 41097 89751507
Drug ineffective for unapproved indication 78.21 9.72 332 835511 66312 89726292
Subcutaneous drug absorption impaired 78.14 9.72 15 835828 13530 89779074
Thyrotoxic crisis 77.96 9.72 75 835768 1156 89791448
Product formulation issue 77.06 9.72 58 835785 625 89791979
Laryngitis 76.84 9.72 227 835616 50526 89742078
Oedema peripheral 76.51 9.72 3006 832837 254909 89537695
Macular degeneration 76.48 9.72 146 835697 37824 89754780
Diplopia 76.37 9.72 490 835353 28224 89764380
Sedation 76.35 9.72 729 835114 47442 89745162
Gestational diabetes 76.28 9.72 243 835600 10339 89782265
Joint dislocation 76.08 9.72 188 835655 44394 89748210
Granuloma skin 75.71 9.72 6 835837 10674 89781930
Panniculitis 75.41 9.72 20 835823 14438 89778166
Sinusitis 75.21 9.72 2501 833342 340587 89452017
Cardiac failure congestive 74.39 9.72 1302 834541 97392 89695212
Female genital tract fistula 74.04 9.72 36 835807 17832 89774772
Anti-cyclic citrullinated peptide antibody 74.01 9.72 85 835758 27136 89765468
Transplant rejection 73.87 9.72 14 835829 12744 89779860
Pyrexia 73.85 9.72 5171 830672 655314 89137290
Toxicity to various agents 73.73 9.72 2055 833788 285791 89506813
Deep vein thrombosis 73.16 9.72 1220 834623 90400 89702204
Flatulence 72.12 9.72 639 835204 40728 89751876
Renal disorder 71.88 9.72 596 835247 37263 89755341
Respiratory disorder neonatal 71.59 9.72 76 835767 1325 89791279
Lip swelling 71.28 9.72 604 835239 38006 89754598
Adverse reaction 71.24 9.72 102 835741 29610 89762994
Oral pain 71.13 9.72 531 835312 32152 89760452
Disability 70.96 9.72 170 835673 40575 89752029
Proctitis 70.83 9.72 26 835817 15233 89777371
Hypoaesthesia 70.64 9.72 2283 833560 311927 89480677
Urticaria 70.37 9.72 2272 833571 310462 89482142
Rhabdomyolysis 70.34 9.72 753 835090 50503 89742101
Hypoacusis 69.66 9.72 468 835375 27382 89765222
Systemic infection 69.47 9.72 143 835700 4632 89787972
Drug-induced liver injury 69.45 9.72 517 835326 89801 89702803
Liver function test abnormal 69.32 9.72 746 835097 50099 89742505
Product administration error 69.11 9.72 449 835394 25974 89766630
Electrocardiogram QT prolonged 69.01 9.72 994 834849 71462 89721142
Dyspnoea 68.39 9.72 9196 826647 871759 88920845
Hepatic cirrhosis 68.28 9.72 325 835518 62928 89729676
Dyspnoea exertional 68.18 9.72 990 834853 71298 89721306
Disorientation 68.14 9.72 664 835179 43450 89749154
Craniopharyngioma 66.99 9.72 32 835811 133 89792471
Eye pain 66.85 9.72 662 835181 43506 89749098
Thyroid hormones increased 66.34 9.72 50 835793 540 89792064
Weight decreased 66.20 9.72 4205 831638 375705 89416899
Product monitoring error 64.84 9.72 135 835708 4409 89788195
Skin haemorrhage 64.54 9.72 377 835466 21003 89771601
Thrombosis 64.34 9.72 991 834852 72260 89720344
Lung disorder 64.31 9.72 983 834860 148900 89643704
Therapeutic drug monitoring analysis not performed 64.23 9.72 70 835773 1259 89791345
Osteoarthritis 63.64 9.72 1348 834495 194382 89598222
Ischaemic stroke 63.16 9.72 385 835458 21781 89770823
Reversible airways obstruction 62.35 9.72 84 835759 1899 89790705
Carpal tunnel syndrome 62.21 9.72 406 835437 23522 89769082
Foreign body in reproductive tract 62.19 9.72 65 835778 1112 89791492
Malaise 62.07 9.72 6241 829602 579745 89212859
Aphasia 62.07 9.72 636 835207 42176 89750428
Reaction to excipient 61.89 9.72 81 835762 1779 89790825
Infusion site reaction 61.55 9.72 51 835792 18988 89773616
Arterial occlusive disease 60.96 9.72 252 835591 12194 89780410
Immunodeficiency 60.76 9.72 200 835643 43034 89749570
Polycystic ovaries 60.64 9.72 150 835693 5504 89787100
Hyperkalaemia 60.59 9.72 888 834955 64076 89728528
Blindness 60.30 9.72 436 835407 26132 89766472
Thyroxine free increased 60.24 9.72 60 835783 967 89791637
Thyroxine increased 60.17 9.72 54 835789 758 89791846
Porphyria acute 59.54 9.72 47 835796 17928 89774676
Temperature regulation disorder 59.46 9.72 30 835813 14549 89778055
Hyperglycaemia 59.24 9.72 725 835118 50245 89742359
Hepatic function abnormal 59.12 9.72 223 835620 46065 89746539
Haemoglobin decreased 58.92 9.72 1932 833911 160024 89632580
Anosmia 58.54 9.72 212 835631 9636 89782968
International normalised ratio increased 58.49 9.72 681 835162 46635 89745969
Product solubility abnormal 58.41 9.72 58 835785 931 89791673
Head injury 58.15 9.72 489 835354 30699 89761905
Blood parathyroid hormone decreased 58.10 9.72 20 835823 12196 89780408
Myxoedema coma 57.96 9.72 40 835803 372 89792232
Joint destruction 57.81 9.72 25 835818 13262 89779342
Insulin-like growth factor increased 57.31 9.72 57 835786 917 89791687
Ejection fraction 57.18 9.72 101 835742 2910 89789694
Hip fracture 57.18 9.72 510 835333 32567 89760037
Walking aid user 56.55 9.72 155 835688 35351 89757253
Skin exfoliation 56.32 9.72 910 834933 67003 89725601
Cerebral haematoma 56.10 9.72 123 835720 4166 89788438
Maternal exposure timing unspecified 56.10 9.72 75 835768 22408 89770196
Haematoma 56.09 9.72 579 835264 38469 89754135
Atrioventricular block 56.03 9.72 194 835649 8621 89783983
Eating disorder 56.03 9.72 447 835396 27626 89764978
Incorrect route of product administration 54.72 9.72 260 835583 50366 89742238
Foetal exposure during pregnancy 54.68 9.72 622 835221 42353 89750251
Blood glucose decreased 54.63 9.72 387 835456 23042 89769562
Renal failure 54.62 9.72 1589 834254 129418 89663186
Hypertensive crisis 54.60 9.72 315 835528 17469 89775135
Hypersomnia 54.57 9.72 363 835480 21168 89771436
COVID-19 54.13 9.72 1985 833858 166858 89625746
Small for dates baby 53.88 9.72 133 835710 4874 89787730
Dysarthria 53.71 9.72 752 835091 53730 89738874
Speech disorder 53.67 9.72 650 835193 44935 89747669
Injection site reaction 53.63 9.72 566 835277 91514 89701090
Thyroid hormones decreased 53.40 9.72 47 835796 642 89791962
Myocardial infarction 53.24 9.72 1317 834526 104655 89687949
Food allergy 53.06 9.72 96 835747 25382 89767222
Pulmonary malformation 52.84 9.72 37 835806 353 89792251
Completed suicide 52.57 9.72 981 834862 144077 89648527
Disease progression 52.26 9.72 1074 834769 155541 89637063
Malabsorption 52.01 9.72 134 835709 5044 89787560
Cystitis 51.65 9.72 884 834959 65834 89726770
Rheumatoid nodule 51.62 9.72 66 835777 20100 89772504
Sleep apnoea syndrome 51.58 9.72 483 835360 31264 89761340
Tenderness 51.02 9.72 423 835420 26445 89766159
Tri-iodothyronine decreased 50.53 9.72 30 835813 209 89792395
Dementia 50.42 9.72 385 835458 23476 89769128
Hallucination 50.36 9.72 872 834971 65087 89727517
Pregnancy 49.71 9.72 351 835492 61696 89730908
Dysphonia 49.62 9.72 838 835005 62246 89730358
Toxic epidermal necrolysis 49.59 9.72 145 835698 32383 89760221
Joint stiffness 49.49 9.72 470 835373 77572 89715032
Incorrect dose administered 49.40 9.72 1012 834831 77918 89714686
Diabetes mellitus inadequate control 49.17 9.72 318 835525 18366 89774238
Restlessness 49.12 9.72 525 835318 35195 89757409
General symptom 49.03 9.72 38 835805 14630 89777974
Jaw disorder 48.93 9.72 137 835706 5422 89787182
Road traffic accident 48.88 9.72 698 835145 106928 89685676
Burning sensation 48.86 9.72 840 835003 62612 89729992
Foetal death 48.84 9.72 72 835771 20651 89771953
Lower limb fracture 48.53 9.72 525 835318 84488 89708116
Drug abuse 48.44 9.72 505 835338 81842 89710762
Chronic sinusitis 48.40 9.72 91 835752 23711 89768893
Hemiparesis 48.20 9.72 477 835366 31342 89761262
Femur fracture 47.85 9.72 642 835201 45440 89747164
Pollakiuria 47.69 9.72 490 835353 32515 89760089
Pemphigoid 47.60 9.72 187 835656 8839 89783765
Diabetes mellitus 47.15 9.72 851 834992 64024 89728580
Atrial septal defect 47.04 9.72 175 835668 8059 89784545
Gastrointestinal haemorrhage 46.96 9.72 1127 834716 89121 89703483
Ageusia 46.93 9.72 281 835562 15795 89776809
Vital capacity decreased 46.78 9.72 70 835773 1749 89790855
Oedema 46.74 9.72 1448 834395 198847 89593757
Subarachnoid haemorrhage 46.68 9.72 304 835539 17600 89775004
Myxoedema 46.36 9.72 25 835818 141 89792463
Soft tissue disorder 46.21 9.72 114 835729 4176 89788428
Loss of consciousness 45.75 9.72 1652 834191 138586 89654018
Dry eye 45.72 9.72 770 835073 57161 89735443
Spinal stenosis 45.52 9.72 296 835547 17128 89775476
Eye pruritus 45.36 9.72 438 835405 28589 89764015
Blood test abnormal 45.36 9.72 340 835503 20612 89771992
Eye swelling 45.23 9.72 442 835401 28944 89763660
Jaundice 45.21 9.72 479 835364 32038 89760566
Carotid artery occlusion 45.14 9.72 145 835698 6197 89786407
Muscle spasms 45.12 9.72 2795 833048 249088 89543516
Heart rate increased 45.05 9.72 1362 834481 111540 89681064
Coordination abnormal 44.80 9.72 344 835499 21012 89771592
Lethargy 44.41 9.72 824 835019 62315 89730289
Thyroxine abnormal 44.34 9.72 12 835831 0 89792604
Haemorrhoids 44.26 9.72 408 835435 26294 89766310
Gallbladder disorder 43.81 9.72 323 835520 19480 89773124
Dyspepsia 43.73 9.72 1443 834400 196717 89595887
Product dispensing error 43.47 9.72 226 835617 12047 89780557
Facial pain 43.46 9.72 238 835605 12944 89779660
Blood sodium decreased 43.32 9.72 417 835426 27196 89765408
Intentional overdose 43.16 9.72 607 835236 93227 89699377
Inappropriate antidiuretic hormone secretion 43.07 9.72 318 835525 19187 89773417
Presyncope 43.05 9.72 466 835377 31339 89761265
Depressed level of consciousness 42.89 9.72 925 834918 71859 89720745
Pituitary tumour recurrent 42.84 9.72 20 835823 78 89792526
Pruritus genital 42.77 9.72 115 835728 4443 89788161
Vaginal discharge 42.66 9.72 71 835772 19393 89773211
Affect lability 42.49 9.72 299 835544 17764 89774840
Neurologic neglect syndrome 42.45 9.72 178 835665 8669 89783935
Faeces discoloured 42.29 9.72 339 835504 20981 89771623
Chromaturia 41.90 9.72 312 835531 18875 89773729
Palmoplantar keratoderma 41.88 9.72 97 835746 3410 89789194
Product physical issue 41.74 9.72 131 835712 5529 89787075
Device adhesion issue 41.73 9.72 6 835837 6685 89785919
Tongue discomfort 41.64 9.72 84 835759 2681 89789923
Arteriosclerosis coronary artery 41.33 9.72 187 835656 9416 89783188
Autoimmune hepatitis 41.19 9.72 197 835646 10154 89782450
Depressed mood 40.91 9.72 671 835172 49551 89743053
Choking 40.85 9.72 219 835624 11814 89780790
Gangrene 40.80 9.72 230 835613 12646 89779958
Drug level increased 40.52 9.72 413 835430 27349 89765255
Acute myocardial infarction 40.42 9.72 496 835347 34394 89758210
Liver disorder 40.33 9.72 832 835011 120437 89672167
Feeling cold 40.28 9.72 409 835434 27056 89765548
Low turnover osteopathy 40.17 9.72 107 835736 4111 89788493
Hepatotoxicity 39.90 9.72 253 835590 45589 89747015
Blood pressure systolic increased 39.85 9.72 758 835085 57587 89735017
Hiatus hernia 39.79 9.72 383 835460 24978 89767626
Cardiospasm 39.72 9.72 94 835749 3352 89789252
Bundle branch block left 39.68 9.72 161 835682 7724 89784880
Rhinorrhoea 39.53 9.72 1081 834762 87235 89705369
Normal newborn 39.48 9.72 99 835744 23263 89769341
Dysuria 39.31 9.72 545 835298 38856 89753748
Hepatitis 39.12 9.72 440 835403 70299 89722305
Atrial tachycardia 39.10 9.72 133 835710 5857 89786747
Overlap syndrome 38.95 9.72 15 835828 8533 89784071
Diffuse alopecia 38.85 9.72 52 835791 1168 89791436
Diverticulum 38.80 9.72 217 835626 11896 89780708
Drug tolerance 38.67 9.72 66 835777 17850 89774754
Product taste abnormal 38.57 9.72 76 835767 2384 89790220
Cardiac failure 38.48 9.72 1301 834542 108195 89684409
Cytomegalovirus infection reactivation 38.45 9.72 12 835831 7788 89784816
Sleep terror 38.30 9.72 109 835734 4355 89788249
Hypocalcaemia 38.28 9.72 576 835267 41792 89750812
Labelled drug-drug interaction medication error 38.26 9.72 248 835595 14334 89778270
Visual impairment 38.11 9.72 1538 834305 130827 89661777
Urinary incontinence 38.04 9.72 521 835322 37045 89755559
Blood thyroid stimulating hormone 38.02 9.72 11 835832 3 89792601
Lung cyst 38.02 9.72 33 835810 442 89792162
Blood calcium increased 37.95 9.72 215 835628 11843 89780761
Hyperlipidaemia 37.91 9.72 350 835493 22566 89770038
Sneezing 37.86 9.72 432 835411 29437 89763167
Post procedural hypothyroidism 37.71 9.72 30 835813 353 89792251
Head discomfort 37.62 9.72 269 835574 16064 89776540
Tension headache 37.54 9.72 153 835690 7356 89785248
Breast cancer stage I 37.49 9.72 21 835822 9603 89783001
Impaired driving ability 37.48 9.72 119 835724 5054 89787550
Drug use disorder 37.42 9.72 15 835828 8328 89784276
Transplant dysfunction 37.35 9.72 3 835840 5279 89787325
Sinus congestion 37.21 9.72 402 835441 27022 89765582
Feeling jittery 37.07 9.72 256 835587 15115 89777489
Peripheral coldness 36.90 9.72 237 835606 13655 89778949
Influenza 36.89 9.72 1604 834239 137660 89654944
Coronary artery disease 36.82 9.72 473 835370 33150 89759454
Multiple drug therapy 36.79 9.72 145 835698 6864 89785740
Rash vesicular 36.62 9.72 70 835773 18127 89774477
Full blood count decreased 36.56 9.72 427 835416 29262 89763342
Heart rate decreased 36.50 9.72 695 835148 52810 89739794
Blood creatinine increased 36.49 9.72 1208 834635 100178 89692426
Device expulsion 36.43 9.72 224 835619 40662 89751942
Carotid artery thrombosis 36.15 9.72 173 835670 8919 89783685
Motor dysfunction 36.11 9.72 302 835541 18928 89773676
Plasma cell myeloma 36.09 9.72 553 835290 40275 89752329
Hemiplegia 35.99 9.72 264 835579 15896 89776708
Pancreatic neuroendocrine tumour 35.86 9.72 36 835807 586 89792018
Sputum culture positive 35.80 9.72 70 835773 2183 89790421
Oesophagitis 35.71 9.72 277 835566 16972 89775632
Irritability 35.46 9.72 493 835350 35169 89757435
Swelling face 35.36 9.72 992 834851 80360 89712244
Withdrawal syndrome 35.26 9.72 340 835503 22184 89770420
Gastrointestinal motility disorder 35.26 9.72 130 835713 5961 89786643
Hepatic enzyme 35.24 9.72 4 835839 5340 89787264
Haemophagocytic lymphohistiocytosis 35.19 9.72 55 835788 15404 89777200
Infective pulmonary exacerbation of cystic fibrosis 35.17 9.72 26 835817 10253 89782351
Coronary artery occlusion 34.91 9.72 164 835679 8390 89784214
Mitral valve incompetence 34.77 9.72 339 835504 22185 89770419
Nightmare 34.53 9.72 329 835514 21396 89771208
Nasal obstruction 34.27 9.72 75 835768 2537 89790067
Musculoskeletal pain 34.11 9.72 1263 834580 169988 89622616
Asthma-chronic obstructive pulmonary disease overlap syndrome 34.05 9.72 3 835840 4896 89787708
Nephritic syndrome 34.05 9.72 29 835814 378 89792226
Chills 34.04 9.72 1516 834327 130465 89662139
Glomerular filtration rate decreased 34.00 9.72 270 835573 16662 89775942
Device difficult to use 33.90 9.72 69 835774 17456 89775148
Eye disorder 33.76 9.72 394 835449 26996 89765608
Extremity contracture 33.60 9.72 50 835793 1243 89791361
Delirium 33.53 9.72 720 835123 103639 89688965
Sinus disorder 33.36 9.72 474 835369 33973 89758631
Rash papular 33.23 9.72 310 835533 20045 89772559
Inner ear disorder 33.20 9.72 37 835806 683 89791921
Epistaxis 33.18 9.72 1024 834819 84101 89708503
Pancreatitis acute 33.17 9.72 447 835396 31668 89760936
Aortic valve incompetence 33.14 9.72 135 835708 6489 89786115
Blood triglycerides increased 33.08 9.72 229 835614 13532 89779072
Pelvic fracture 32.97 9.72 247 835596 14972 89777632
Grip strength 32.90 9.72 21 835822 8944 89783660
Injection site mass 32.90 9.72 330 835513 21760 89770844
Product measured potency issue 32.89 9.72 18 835825 105 89792499
Product odour abnormal 32.86 9.72 55 835788 1516 89791088
Bone marrow failure 32.79 9.72 169 835674 32052 89760552
Ventricular extrasystoles 32.74 9.72 222 835621 13028 89779576
Pathogen resistance 32.65 9.72 17 835826 8098 89784506
Lactose intolerance 32.63 9.72 86 835757 3283 89789321
Body height decreased 32.45 9.72 205 835638 11744 89780860
Exophthalmos 32.37 9.72 59 835784 1743 89790861
Trichorrhexis 32.36 9.72 53 835790 1434 89791170
Ventricular hypertrophy 32.27 9.72 86 835757 3305 89789299
Intervertebral disc protrusion 32.10 9.72 388 835455 26808 89765796
Bundle branch block right 32.08 9.72 117 835726 5336 89787268
Blood pressure inadequately controlled 32.05 9.72 128 835715 6096 89786508
Blood loss anaemia 32.04 9.72 181 835662 9959 89782645
Red blood cell sedimentation rate 31.98 9.72 3 835840 4655 89787949
Product colour issue 31.97 9.72 38 835805 754 89791850
Immunisation 31.87 9.72 66 835777 2147 89790457
Venoocclusive liver disease 31.81 9.72 8 835835 5985 89786619
Scar 31.75 9.72 247 835596 15148 89777456
Papillary thyroid cancer 31.75 9.72 73 835770 2554 89790050
Adjustment disorder 31.73 9.72 174 835669 9468 89783136
Tooth fracture 31.67 9.72 212 835631 12388 89780216
Blood pressure decreased 31.64 9.72 910 834933 73985 89718619
Renal dysplasia 31.39 9.72 27 835816 357 89792247
Thyrotoxic periodic paralysis 31.38 9.72 12 835831 24 89792580
Sickle cell anaemia with crisis 31.32 9.72 14 835829 7283 89785321
Malignant melanoma 31.25 9.72 211 835632 12365 89780239
Blood growth hormone increased 31.15 9.72 31 835812 499 89792105
Alloimmunisation 31.15 9.72 10 835833 8 89792596
Abnormal dreams 31.11 9.72 194 835649 11063 89781541
Oral discomfort 31.09 9.72 184 835659 10299 89782305
Thinking abnormal 31.07 9.72 200 835643 11532 89781072
Cerebral haemorrhage 31.06 9.72 469 835374 34053 89758551
Scleral discolouration 30.93 9.72 29 835814 432 89792172
Blood potassium decreased 30.88 9.72 615 835228 47112 89745492
Transcription medication error 30.85 9.72 23 835820 244 89792360
Diverticulitis 30.84 9.72 587 835256 44600 89748004
Cardiac pacemaker insertion 30.68 9.72 100 835743 4307 89788297
Panic attack 30.62 9.72 375 835468 25990 89766614
Hepatic steatosis 30.61 9.72 495 835348 36450 89756154
Sopor 30.59 9.72 355 835488 24289 89768315
Listless 30.52 9.72 82 835761 3167 89789437
Visual field defect 30.43 9.72 139 835704 7027 89785577
Neurotoxicity 30.38 9.72 99 835744 21368 89771236
Post transplant lymphoproliferative disorder 30.35 9.72 13 835830 6936 89785668
Emotional distress 30.30 9.72 491 835352 36171 89756433
Melaena 30.26 9.72 470 835373 34327 89758277
Rhinitis allergic 30.15 9.72 261 835582 16524 89776080
Multiple allergies 30.13 9.72 241 835602 14905 89777699
Ear infection 30.12 9.72 457 835386 69318 89723286
Haematotoxicity 30.08 9.72 43 835800 12492 89780112
Micturition urgency 30.06 9.72 192 835651 11041 89781563
Diabetic ketoacidosis 30.04 9.72 351 835492 24056 89768548
Cytokine release syndrome 30.03 9.72 144 835699 27829 89764775
Ventricular tachycardia 29.82 9.72 354 835489 24354 89768250
Lacrimation increased 29.76 9.72 381 835462 26681 89765923
Hair texture abnormal 29.66 9.72 103 835740 4584 89788020
Dilatation atrial 29.62 9.72 60 835783 1921 89790683
Thrombotic microangiopathy 29.60 9.72 63 835780 15680 89776924
Ecchymosis 29.58 9.72 205 835638 12118 89780486
Recalled product 29.57 9.72 49 835794 1339 89791265
Hormone level abnormal 29.53 9.72 75 835768 2798 89789806
Polymyalgia rheumatica 29.46 9.72 107 835736 4870 89787734
Radiculopathy 29.31 9.72 81 835762 18424 89774180
Lactic acidosis 29.30 9.72 640 835203 49823 89742781
Oropharyngeal pain 29.25 9.72 1321 834522 113866 89678738
Haematochezia 29.24 9.72 859 834984 70054 89722550
Congenital anomaly 29.15 9.72 11 835832 6336 89786268
Tonsillar disorder 29.13 9.72 45 835798 1157 89791447
Abdominal pain lower 29.13 9.72 415 835428 29762 89762842
Dermatitis atopic 29.09 9.72 338 835505 23134 89769470
Sciatica 29.04 9.72 712 835131 100670 89691934
Mental status changes 29 9.72 576 835267 44103 89748501
Mucosal inflammation 28.96 9.72 366 835477 57259 89735345
Sensation of foreign body 28.93 9.72 126 835717 6240 89786364
Pneumonia viral 28.89 9.72 159 835684 8664 89783940
Tooth abscess 28.85 9.72 254 835589 16159 89776445
Urinary retention 28.81 9.72 499 835344 37245 89755359
Pleural effusion 28.80 9.72 1286 834557 110705 89681899
Ejection fraction abnormal 28.77 9.72 68 835775 2423 89790181
Polyp 28.64 9.72 143 835700 7501 89785103
Product packaging issue 28.56 9.72 53 835790 1588 89791016
Psychomotor skills impaired 28.52 9.72 74 835769 2798 89789806
Muscle twitching 28.44 9.72 345 835498 23857 89768747
Blood alkaline phosphatase increased 28.31 9.72 611 835232 47468 89745136
Enthesopathy 28.23 9.72 27 835816 9377 89783227
Dental caries 28.19 9.72 191 835652 11206 89781398
Respiratory disorder 28.16 9.72 424 835419 64392 89728212
Intervertebral disc degeneration 28.16 9.72 263 835580 17011 89775593
Hypophagia 28.12 9.72 477 835366 35460 89757144
Congenital absence of vertebra 28.04 9.72 12 835831 36 89792568
Sprue-like enteropathy 27.90 9.72 39 835804 914 89791690
Supraventricular extrasystoles 27.79 9.72 109 835734 5148 89787456
Gastric disorder 27.55 9.72 447 835396 32937 89759667
Arteriosclerosis 27.52 9.72 183 835660 10670 89781934
Somatic delusion 27.37 9.72 31 835812 583 89792021
Hypopituitarism 27.29 9.72 54 835789 1699 89790905
Gingival disorder 27.28 9.72 90 835753 3901 89788703
Therapeutic product effect variable 27.16 9.72 50 835793 1489 89791115
Adverse drug reaction 27.13 9.72 844 834999 115857 89676747
Paroxysmal extreme pain disorder 27.12 9.72 16 835827 110 89792494
Spondylolisthesis 27.06 9.72 91 835752 3984 89788620
Angle closure glaucoma 27.04 9.72 71 835772 2704 89789900
Vitamin D deficiency 26.99 9.72 264 835579 17292 89775312
Tension 26.95 9.72 85 835758 3597 89789007
Glycosylated haemoglobin increased 26.92 9.72 240 835603 15322 89777282
Upper limb fracture 26.86 9.72 311 835532 21267 89771337
Mouth injury 26.86 9.72 43 835800 1141 89791463
Thyroxine free decreased 26.78 9.72 36 835807 812 89791792
Urine odour abnormal 26.78 9.72 135 835708 7109 89785495
Migraine 26.71 9.72 1459 834384 188933 89603671
Apathy 26.70 9.72 184 835659 10856 89781748
Nerve compression 26.69 9.72 178 835665 10388 89782216
Spondylitis 26.44 9.72 57 835786 14121 89778483
Sensory loss 26.43 9.72 269 835574 17806 89774798
Therapy partial responder 26.36 9.72 109 835734 21934 89770670
Visual acuity reduced 26.34 9.72 331 835512 23079 89769525
Chronic respiratory disease 26.32 9.72 22 835821 279 89792325
Nasal congestion 26.31 9.72 979 834864 82435 89710169
Respiratory tract malformation 26.29 9.72 18 835825 165 89792439
Ulcer haemorrhage 26.26 9.72 139 835704 26182 89766422
Exposure to toxic agent 26.18 9.72 21 835822 7946 89784658
Multiple-drug resistance 26.18 9.72 20 835823 7756 89784848
Drug withdrawal syndrome 26.15 9.72 391 835452 28332 89764272
Piloerection 26.09 9.72 31 835812 615 89791989
Body temperature decreased 26.06 9.72 335 835508 23481 89769123
Therapeutic response decreased 26.01 9.72 629 835214 89100 89703504
Eyelid oedema 26.01 9.72 189 835654 11345 89781259
Varicose vein 26.00 9.72 135 835708 7192 89785412
Contusion 26.00 9.72 1979 833864 249237 89543367
Anxiety disorder 25.97 9.72 102 835741 4820 89787784
Personality disorder 25.85 9.72 200 835643 12244 89780360
Tooth disorder 25.55 9.72 416 835427 30674 89761930
Pituitary tumour benign 25.49 9.72 59 835784 2073 89790531
Skin necrosis 25.48 9.72 76 835767 16865 89775739
Inappropriate schedule of product administration 25.41 9.72 1656 834187 148277 89644327
Therapeutic product effect increased 25.22 9.72 44 835799 1255 89791349
Needle issue 25.20 9.72 217 835626 13717 89778887
Product residue present 25.19 9.72 92 835751 4199 89788405
Nephrectomy 25.00 9.72 56 835787 1925 89790679
Persistent depressive disorder 24.96 9.72 43 835800 1214 89791390
Tricuspid valve incompetence 24.94 9.72 250 835593 16481 89776123
Hepatitis acute 24.90 9.72 179 835664 10708 89781896
Adenovirus infection 24.86 9.72 6 835837 4616 89787988
Swollen tongue 24.85 9.72 577 835266 45379 89747225
Hypothermia 24.82 9.72 236 835607 15339 89777265
Dysstasia 24.78 9.72 346 835497 24706 89767898
Intramedullary rod insertion 24.77 9.72 59 835784 2113 89790491
Muscle fatigue 24.70 9.72 71 835772 2853 89789751
Cerebral salt-wasting syndrome 24.63 9.72 19 835824 213 89792391
Thyroxine decreased 24.63 9.72 31 835812 654 89791950
Wrist fracture 24.53 9.72 236 835607 15388 89777216
Sinus rhythm 24.42 9.72 45 835798 1341 89791263
Hypokalaemia 24.41 9.72 1460 834383 129656 89662948
Agitation 24.28 9.72 800 835043 66298 89726306
Blood urea increased 24.28 9.72 405 835438 30008 89762596
Pain in extremity 24.27 9.72 4611 831232 445918 89346686
Goitre 24.24 9.72 125 835718 6642 89785962
Breast discomfort 24.23 9.72 30 835813 622 89791982
Increased tendency to bruise 24.10 9.72 190 835653 11700 89780904
Flushing 24.05 9.72 1022 834821 87469 89705135
Anaemia postoperative 24.04 9.72 59 835784 2154 89790450
Insulin-like growth factor decreased 24.04 9.72 24 835819 388 89792216
Gingival pain 24.02 9.72 162 835681 9490 89783114
Acute graft versus host disease in skin 24.02 9.72 7 835836 4749 89787855
Metastatic renal cell carcinoma 24.00 9.72 34 835809 807 89791797
Subdural haematoma 23.99 9.72 247 835596 16398 89776206
Pustular psoriasis 23.95 9.72 89 835754 18467 89774137
Heart rate irregular 23.93 9.72 335 835508 23933 89768671
Change of bowel habit 23.89 9.72 60 835783 2223 89790381
Petechiae 23.85 9.72 236 835607 15505 89777099
Pain of skin 23.83 9.72 240 835603 15842 89776762
Atrioventricular block first degree 23.73 9.72 147 835696 8364 89784240
Cytomegalovirus viraemia 23.69 9.72 21 835822 7565 89785039
Pulmonary arterial hypertension 23.65 9.72 356 835487 25831 89766773
Oral candidiasis 23.57 9.72 211 835632 35244 89757360
Lymphadenectomy 23.56 9.72 41 835802 1167 89791437
Rib deformity 23.52 9.72 20 835823 260 89792344
Bradykinesia 23.35 9.72 124 835719 6664 89785940
Concomitant disease aggravated 23.31 9.72 184 835659 11334 89781270
Magnetic resonance imaging thoracic abnormal 23.22 9.72 9 835834 19 89792585
Rotator cuff repair 23.11 9.72 62 835781 2392 89790212
International normalised ratio abnormal 23.05 9.72 83 835760 3762 89788842
Palmar-plantar erythrodysaesthesia syndrome 23.04 9.72 375 835468 27648 89764956
Large intestine polyp 23.04 9.72 157 835686 9229 89783375
Neovascular age-related macular degeneration 23.04 9.72 24 835819 409 89792195
Degenerative bone disease 23.03 9.72 20 835823 268 89792336
Crying 22.92 9.72 348 835495 25297 89767307
Aphonia 22.89 9.72 193 835650 12126 89780478
Papillitis 22.79 9.72 11 835832 47 89792557
Oropharyngeal swelling 22.57 9.72 35 835808 903 89791701
Limb discomfort 22.51 9.72 484 835359 37576 89755028
Atrial flutter 22.40 9.72 173 835670 10585 89782019
Overdose 22.40 9.72 1207 834636 156502 89636102
Polyuria 22.35 9.72 164 835679 9876 89782728
Anaphylactic reaction 22.34 9.72 625 835218 86899 89705705
Bladder disorder 22.31 9.72 173 835670 10599 89782005
Pre-existing condition improved 22.29 9.72 153 835690 9016 89783588
Therapeutic response changed 22.25 9.72 42 835801 1275 89791329
Gamma-glutamyltransferase increased 22.25 9.72 482 835361 37470 89755134
Blood creatine phosphokinase increased 22.21 9.72 439 835404 33584 89759020
Congenital renal cyst 22.14 9.72 7 835836 5 89792599
Temperature intolerance 22.10 9.72 188 835655 11842 89780762
Onychoclasis 22.03 9.72 130 835713 7269 89785335
Renal function test abnormal 21.83 9.72 127 835716 7064 89785540
Product tampering 21.70 9.72 24 835819 439 89792165
Spondylolysis 21.69 9.72 15 835828 140 89792464
Colitis ulcerative 21.69 9.72 408 835435 59858 89732746
Cholelithiasis 21.64 9.72 636 835207 51870 89740734
Subdural hygroma 21.62 9.72 19 835824 259 89792345
Pulse abnormal 21.55 9.72 70 835773 3009 89789595
Electrolyte imbalance 21.52 9.72 323 835520 23422 89769182
Musculoskeletal chest pain 21.50 9.72 323 835520 23427 89769177
Rib fracture 21.46 9.72 353 835490 26082 89766522
Device material issue 21.40 9.72 23 835820 407 89792197
Application site erythema 21.36 9.72 100 835743 5108 89787496
Ocular hyperaemia 21.36 9.72 434 835409 33364 89759240
Throat clearing 21.35 9.72 81 835762 3766 89788838
Poisoning deliberate 21.33 9.72 79 835764 16407 89776197
Mood altered 21.30 9.72 247 835596 16897 89775707
Lupus nephritis 21.17 9.72 9 835834 4823 89787781
Anal incontinence 21.14 9.72 236 835607 15994 89776610
Electrocardiogram abnormal 21.11 9.72 165 835678 10133 89782471
Hypophysitis 21.10 9.72 61 835782 2459 89790145
Aplastic anaemia 21.07 9.72 58 835785 13211 89779393
Internal haemorrhage 20.98 9.72 113 835730 6107 89786497
Electrocardiogram ST-T segment abnormal 20.92 9.72 23 835820 418 89792186
Chest pain 20.87 9.72 3305 832538 316340 89476264
Skin abrasion 20.86 9.72 176 835667 11059 89781545
Tri-iodothyronine free decreased 20.84 9.72 22 835821 381 89792223
Ingrowing nail 20.81 9.72 66 835777 2801 89789803
Spinal osteoarthritis 20.81 9.72 269 835574 18879 89773725
Microcephaly 20.79 9.72 42 835801 1342 89791262
Maternal exposure during delivery 20.68 9.72 5 835838 3841 89788763
Coombs positive haemolytic anaemia 20.59 9.72 24 835819 466 89792138
Gait disturbance 20.42 9.72 2722 833121 257774 89534830
Multiple organ dysfunction syndrome 20.37 9.72 477 835366 67859 89724745
Endocrine ophthalmopathy 20.36 9.72 36 835807 1038 89791566
Frequent bowel movements 20.32 9.72 386 835457 56549 89736055
Post procedural hypoparathyroidism 20.30 9.72 8 835835 18 89792586
Underdose 20.28 9.72 363 835480 53654 89738950
Lymphoproliferative disorder 20.23 9.72 7 835836 4255 89788349
Exercise tolerance decreased 20.17 9.72 129 835714 7422 89785182
Muscle tightness 20.13 9.72 201 835642 13238 89779366
Stress 20.12 9.72 931 834912 80464 89712140
Cystitis haemorrhagic 20.12 9.72 13 835830 5500 89787104
Product blister packaging issue 20.09 9.72 20 835823 322 89792282
Pituitary tumour 20.07 9.72 33 835810 896 89791708
Broncholithiasis 20.00 9.72 19 835824 288 89792316
Anger 19.97 9.72 204 835639 13516 89779088
Stress fracture 19.94 9.72 142 835701 8469 89784135
Local anaesthetic systemic toxicity 19.93 9.72 4 835839 3496 89789108
Confusional arousal 19.90 9.72 19 835824 290 89792314
Thyroglobulin increased 19.85 9.72 11 835832 66 89792538
Neonatal thyrotoxicosis 19.77 9.72 6 835837 3 89792601
Nocturia 19.76 9.72 162 835681 10093 89782511
Agitation neonatal 19.73 9.72 25 835818 531 89792073
Respiratory tract congestion 19.72 9.72 359 835484 27051 89765553
Sinus bradycardia 19.64 9.72 241 835602 16711 89775893
Labile hypertension 19.63 9.72 24 835819 491 89792113
Claustrophobia 19.61 9.72 40 835803 1287 89791317
Initial insomnia 19.55 9.72 150 835693 9160 89783444
Gingival recession 19.50 9.72 47 835796 1696 89790908
Carotid artery stenosis 19.43 9.72 99 835744 5235 89787369
Melanocytic naevus 19.42 9.72 97 835746 5089 89787515
Angioedema 19.41 9.72 757 835086 64119 89728485
Hallucination, visual 19.36 9.72 310 835533 22782 89769822
Myopathy toxic 19.29 9.72 26 835817 588 89792016
Mean cell haemoglobin concentration increased 19.26 9.72 26 835817 589 89792015
Tetany 19.23 9.72 60 835783 2524 89790080
Hypoglycaemia neonatal 19.23 9.72 36 835807 1086 89791518
Cerebellar haematoma 19.21 9.72 21 835822 379 89792225
Genital swelling 19.13 9.72 14 835829 144 89792460
Cyanosis neonatal 19.12 9.72 22 835821 421 89792183
Abnormal uterine bleeding 19.12 9.72 51 835792 1961 89790643
Unintentional medical device removal 19.06 9.72 22 835821 7008 89785596
Orthostatic intolerance 19.05 9.72 40 835803 1314 89791290
Haemorrhage 19.04 9.72 802 835041 68567 89724037
Dactylitis 19.02 9.72 6 835837 3867 89788737
C-reactive protein 19.00 9.72 191 835652 31176 89761428
Middle insomnia 18.91 9.72 237 835606 16514 89776090
Psychomotor hyperactivity 18.88 9.72 191 835652 12622 89779982
Graft versus host disease in skin 18.86 9.72 6 835837 3847 89788757
Musculoskeletal discomfort 18.82 9.72 285 835558 20706 89771898
Frontotemporal dementia 18.74 9.72 21 835822 390 89792214
Fracture nonunion 18.73 9.72 55 835788 2237 89790367
Rectourethral fistula 18.69 9.72 8 835835 24 89792580
Obstructive airways disorder 18.67 9.72 339 835504 25530 89767074
Procedural pain 18.64 9.72 207 835636 33153 89759451
Haemorrhagic stroke 18.61 9.72 113 835730 6383 89786221
Neuromyopathy 18.60 9.72 29 835814 752 89791852
Restless legs syndrome 18.59 9.72 301 835542 22169 89770435
Blood pressure abnormal 18.50 9.72 269 835574 19376 89773228
Thyroid cancer recurrent 18.46 9.72 10 835833 57 89792547
Thyroid dermatopathy 18.46 9.72 8 835835 25 89792579
Groin pain 18.45 9.72 183 835660 12030 89780574
Cholecystitis 18.36 9.72 239 835604 16801 89775803
Open reduction of fracture 18.34 9.72 36 835807 1126 89791478
Cellulitis 18.33 9.72 1024 834819 90313 89702291
Chronic kidney disease 18.30 9.72 599 835244 49592 89743012
Decreased appetite 18.25 9.72 3834 832009 372706 89419898
Retrograde amnesia 18.24 9.72 24 835819 530 89792074
Vertigo positional 18.22 9.72 70 835773 3274 89789330
Aspergillus infection 18.18 9.72 46 835797 10777 89781827
Bone formation increased 18.15 9.72 14 835829 157 89792447
Epstein-Barr virus infection 18.14 9.72 43 835800 10301 89782303
Increased appetite 18.12 9.72 177 835666 11588 89781016
Urine output increased 18.12 9.72 46 835797 1716 89790888
Juvenile idiopathic arthritis 18.09 9.72 7 835836 3970 89788634
Skin laceration 18.04 9.72 339 835504 25696 89766908
Congenital nystagmus 18.03 9.72 9 835834 42 89792562
Hepatitis cholestatic 18.01 9.72 138 835705 8423 89784181
General physical health deterioration 17.94 9.72 2939 832904 352176 89440428
Barrett's oesophagus 17.93 9.72 24 835819 539 89792065
Muscular weakness 17.92 9.72 2173 833670 204493 89588111
Reaction to preservatives 17.92 9.72 16 835827 223 89792381
Lymph node calcification 17.91 9.72 20 835823 370 89792234
Tachycardia 17.90 9.72 1688 834155 155985 89636619
Upper-airway cough syndrome 17.89 9.72 216 835627 14919 89777685
Circulatory collapse 17.85 9.72 326 835517 24578 89768026
Kidney malrotation 17.79 9.72 8 835835 28 89792576
Tooth dislocation 17.79 9.72 8 835835 28 89792576
Adenoid cystic carcinoma 17.79 9.72 8 835835 28 89792576
Skin disorder 17.78 9.72 454 835389 36252 89756352
Insomnia 17.73 9.72 3411 832432 330063 89462541
Hepatocellular carcinoma 17.72 9.72 56 835787 2372 89790232
Gastrointestinal toxicity 17.70 9.72 38 835805 9429 89783175
Thyroxine free abnormal 17.69 9.72 7 835836 16 89792588
Chronic graft versus host disease 17.67 9.72 8 835835 4131 89788473
Suicidal ideation 17.67 9.72 842 835001 73013 89719591
Hair growth abnormal 17.67 9.72 74 835769 3602 89789002
Intervertebral disc disorder 17.61 9.72 98 835745 5362 89787242
Abdominal distension 17.60 9.72 1416 834427 129185 89663419
Blood glucose fluctuation 17.59 9.72 93 835750 4990 89787614
Intentional underdose 17.55 9.72 50 835793 1999 89790605
Osteopenia 17.52 9.72 304 835539 22698 89769906
Retching 17.51 9.72 261 835582 18898 89773706
Diabetic neuropathy 17.44 9.72 86 835757 4488 89788116
Gastrointestinal tract irritation 17.41 9.72 25 835818 601 89792003
Blood cholesterol decreased 17.40 9.72 48 835795 1883 89790721
Low density lipoprotein increased 17.39 9.72 131 835712 7954 89784650
Pigmentation disorder 17.38 9.72 104 835739 5845 89786759
Sinus node dysfunction 17.36 9.72 97 835746 5315 89787289
Large intestine infection 17.35 9.72 59 835784 2598 89790006
Ischaemic hepatitis 17.35 9.72 61 835782 2732 89789872
Bone loss 17.34 9.72 71 835772 3421 89789183
Bruxism 17.33 9.72 83 835760 4280 89788324
Lumbar radiculopathy 17.33 9.72 58 835785 2533 89790071
Basedow's disease 17.31 9.72 17 835826 269 89792335
Emotional disorder 17.28 9.72 213 835630 14784 89777820
Blood glucose abnormal 17.26 9.72 148 835695 9344 89783260
Peripheral vascular disorder 17.26 9.72 110 835733 6321 89786283
BK virus infection 17.26 9.72 10 835833 4488 89788116
Skin discolouration 17.24 9.72 533 835310 43782 89748822
Milk-alkali syndrome 17.21 9.72 37 835806 1236 89791368
Neutrophil count decreased 17.19 9.72 515 835328 71017 89721587
Cardio-respiratory arrest 17.12 9.72 447 835396 62693 89729911
Feeling drunk 17.12 9.72 88 835755 4670 89787934
Vessel puncture site haemorrhage 17.09 9.72 12 835831 115 89792489
Chronic obstructive pulmonary disease 17.09 9.72 839 835004 72990 89719614
Complication of device insertion 17.06 9.72 159 835684 10277 89782327
Migraine with aura 17.03 9.72 67 835776 3169 89789435
Diastolic dysfunction 17.02 9.72 121 835722 7212 89785392
Fear 17.02 9.72 231 835612 16391 89776213
Weight increased 16.99 9.72 3499 832344 414428 89378176
Rectal polyp 16.99 9.72 34 835809 1079 89791525
Psoriasis 16.95 9.72 1583 834260 146171 89646433
Hypomagnesaemia 16.90 9.72 439 835404 35149 89757455
Laryngeal pain 16.76 9.72 83 835760 4339 89788265
Colitis microscopic 16.76 9.72 167 835676 10992 89781612
Electrocardiogram ST segment abnormal 16.65 9.72 35 835808 1151 89791453
Type 1 diabetes mellitus 16.62 9.72 88 835755 4724 89787880
Hyperadrenalism 16.60 9.72 7 835836 20 89792584
Erythema dyschromicum perstans 16.58 9.72 10 835833 72 89792532
Muscle contractions involuntary 16.54 9.72 62 835781 2866 89789738
Graft versus host disease in gastrointestinal tract 16.49 9.72 10 835833 4378 89788226
Oesophageal obstruction 16.48 9.72 26 835817 681 89791923
Hepatitis B reactivation 16.48 9.72 8 835835 3966 89788638
Traumatic ulcer 16.38 9.72 9 835834 53 89792551
Faecal vomiting 16.37 9.72 28 835815 786 89791818
Hypoglycaemic unconsciousness 16.37 9.72 28 835815 786 89791818
Iron deficiency anaemia 16.36 9.72 308 835535 23354 89769250
Blood insulin increased 16.34 9.72 13 835830 153 89792451
Gout 16.33 9.72 232 835611 16627 89775977
Lip blister 16.30 9.72 61 835782 2817 89789787
Presbyacusis 16.26 9.72 4 835839 3038 89789566
Peptic ulcer 16.17 9.72 96 835747 5379 89787225
Mass 16.16 9.72 217 835626 15360 89777244
Pain threshold decreased 16.15 9.72 5 835838 3 89792601
Vocal cord paresis 16.12 9.72 12 835831 127 89792477
Vitello-intestinal duct remnant 16.09 9.72 8 835835 37 89792567
Congenital eye disorder 16.09 9.72 8 835835 37 89792567
Urine sodium decreased 16.07 9.72 13 835830 157 89792447
Mouth breathing 16.07 9.72 13 835830 157 89792447
Paranoia 16.05 9.72 186 835657 12722 89779882
Renal impairment 16.03 9.72 1154 834689 104267 89688337
Retinal artery embolism 16.03 9.72 10 835833 77 89792527
Pneumocystis jirovecii pneumonia 16.01 9.72 125 835718 21491 89771113
Bronchitis 16.01 9.72 1628 834215 151299 89641305
Haematemesis 16.00 9.72 416 835427 33310 89759294
Ocular discomfort 15.90 9.72 107 835736 6263 89786341
Neck injury 15.88 9.72 54 835789 2378 89790226
Sjogren's syndrome 15.85 9.72 32 835811 1022 89791582
Renal cyst 15.83 9.72 186 835657 12764 89779840
Cholecystectomy 15.80 9.72 172 835671 11583 89781021
Congenital acrochordon 15.76 9.72 8 835835 39 89792565
HIV infection 15.75 9.72 21 835822 470 89792134
Poor quality product administered 15.74 9.72 76 835767 3932 89788672
Haematoma muscle 15.70 9.72 45 835798 1805 89790799
Diabetes insipidus 15.70 9.72 65 835778 3147 89789457
Tracheobronchitis bacterial 15.69 9.72 6 835837 12 89792592
Anti-thyroid antibody positive 15.65 9.72 21 835822 473 89792131
Pulmonary hypertension 15.64 9.72 508 835335 42015 89750589
Product coating issue 15.62 9.72 11 835832 106 89792498
Overweight 15.62 9.72 101 835742 5833 89786771
Adenoiditis 15.60 9.72 8 835835 40 89792564
Osteoporosis 15.60 9.72 729 835114 95802 89696802
Skin cancer 15.58 9.72 192 835651 13327 89779277
Ventilation perfusion mismatch 15.54 9.72 23 835820 569 89792035
Antinuclear antibody negative 15.48 9.72 16 835827 270 89792334
Troponin increased 15.47 9.72 189 835654 13092 89779512
Pleuritic pain 15.44 9.72 156 835687 10305 89782299
Rash macular 15.40 9.72 377 835466 29903 89762701
Nasal oedema 15.40 9.72 23 835820 6561 89786043
Chronic lymphocytic leukaemia 15.38 9.72 64 835779 3106 89789498
Pulmonary valve incompetence 15.36 9.72 42 835801 1639 89790965
Pernicious anaemia 15.34 9.72 28 835815 828 89791776
Extrasystoles 15.33 9.72 97 835746 5560 89787044
Lower gastrointestinal haemorrhage 15.31 9.72 137 835706 8755 89783849
Exposure via ingestion 15.29 9.72 3 835840 2664 89789940
Muscle atrophy 15.28 9.72 131 835712 8270 89784334
Inappropriate affect 15.27 9.72 31 835812 994 89791610
Blood creatine phosphokinase decreased 15.25 9.72 25 835818 677 89791927
Thyroid mass 15.25 9.72 93 835750 5262 89787342
Decreased bronchial secretion 15.24 9.72 9 835834 62 89792542
Cardiac fibrillation 15.19 9.72 23 835820 581 89792023
Lumbar spinal stenosis 15.18 9.72 96 835747 5501 89787103
Bronchopulmonary aspergillosis 15.15 9.72 54 835789 11344 89781260
Swollen joint count 15.15 9.72 36 835807 8617 89783987
Vulvovaginal discomfort 15.14 9.72 57 835786 2640 89789964
Intestinal haemorrhage 15.14 9.72 81 835762 4366 89788238
Essential hypertension 15.13 9.72 105 835738 6210 89786394
Hyponatraemic seizure 15.12 9.72 21 835822 489 89792115
Cardiotoxicity 15.11 9.72 54 835789 11335 89781269
Recalled product administered 15.04 9.72 27 835816 788 89791816
Pancreatic enzymes increased 15.02 9.72 28 835815 842 89791762
Hypotensive transfusion reaction 14.99 9.72 8 835835 44 89792560
No adverse event 14.99 9.72 495 835348 67487 89725117
Ear canal erythema 14.99 9.72 8 835835 44 89792560
Eructation 14.99 9.72 160 835683 10722 89781882
Graft versus host disease 14.97 9.72 33 835810 8111 89784493
Cold sweat 14.96 9.72 197 835646 13884 89778720
Oesophageal disorder 14.95 9.72 57 835786 2656 89789948
Polyhydramnios 14.91 9.72 54 835789 2454 89790150
High density lipoprotein decreased 14.86 9.72 56 835787 2595 89790009
Gastric pH increased 14.85 9.72 8 835835 45 89792559
Erysipelas 14.84 9.72 138 835705 8914 89783690
Expired product administered 14.80 9.72 112 835731 6810 89785794
Oesophageal achalasia 14.80 9.72 24 835819 644 89791960
Arrhythmia neonatal 14.78 9.72 9 835834 66 89792538
Craniocerebral injury 14.78 9.72 65 835778 3233 89789371
Skin tightness 14.77 9.72 81 835762 4407 89788197
Parathyroid tumour benign 14.77 9.72 29 835814 907 89791697
Cholestasis 14.77 9.72 439 835404 35860 89756744
Facial paralysis 14.74 9.72 213 835630 15321 89777283
Oedema mouth 14.72 9.72 52 835791 2334 89790270
Tooth resorption 14.71 9.72 8 835835 46 89792558
Upper respiratory tract infection 14.70 9.72 1002 834841 127316 89665288
Pleural neoplasm 14.70 9.72 19 835824 412 89792192
Abnormal weight gain 14.69 9.72 56 835787 2609 89789995
Disease recurrence 14.68 9.72 453 835390 37200 89755404
Product use complaint 14.61 9.72 68 835775 3465 89789139
Ankle arthroplasty 14.61 9.72 4 835839 2827 89789777
Thyrotoxic cardiomyopathy 14.59 9.72 5 835838 6 89792598
Electrocardiogram T wave inversion 14.59 9.72 70 835773 3613 89788991
Eye inflammation 14.58 9.72 123 835720 7728 89784876
Anal prolapse 14.58 9.72 10 835833 92 89792512
Rheumatoid lung 14.53 9.72 10 835833 4093 89788511
Bronchial secretion retention 14.53 9.72 69 835774 3546 89789058
Congenital hydronephrosis 14.53 9.72 19 835824 417 89792187
Autoimmune myocarditis 14.52 9.72 15 835828 253 89792351
Mitral valve stenosis 14.52 9.72 36 835807 1323 89791281
Amniotic fluid volume increased 14.46 9.72 13 835830 183 89792421
Coronavirus test positive 14.46 9.72 28 835815 867 89791737
Extra dose administered 14.45 9.72 138 835705 8980 89783624
Pallor 14.39 9.72 415 835428 33750 89758854
Haemoptysis 14.39 9.72 406 835437 32914 89759690
Product packaging confusion 14.39 9.72 14 835829 219 89792385
Choroidal effusion 14.39 9.72 26 835817 763 89791841
Energy increased 14.26 9.72 62 835781 3068 89789536
Endocrine disorder 14.26 9.72 29 835814 931 89791673
Bronchial obstruction 14.26 9.72 41 835802 1648 89790956
Mitral valve sclerosis 14.24 9.72 12 835831 154 89792450
Polyglandular autoimmune syndrome type II 14.18 9.72 8 835835 50 89792554
Periorbital inflammation 14.17 9.72 13 835830 188 89792416
Thirst 14.13 9.72 220 835623 16075 89776529
Confusional state 14.13 9.72 3250 832593 382955 89409649
Sodium retention 14.11 9.72 12 835831 156 89792448
Weight loss poor 14.11 9.72 37 835806 1408 89791196
Vaginal haemorrhage 14.06 9.72 383 835460 30888 89761716
Cerebral ischaemia 14.04 9.72 114 835729 7082 89785522
Aortic valve sclerosis 13.94 9.72 33 835810 1177 89791427
Product label issue 13.93 9.72 29 835814 947 89791657
Uterine cyst 13.93 9.72 20 835823 481 89792123
Dry mouth 13.92 9.72 1485 834358 182574 89610030
Stress urinary incontinence 13.91 9.72 52 835791 2400 89790204
Bradycardia neonatal 13.91 9.72 31 835812 1062 89791542
Hypernatraemia 13.87 9.72 140 835703 9247 89783357
Premature baby 13.85 9.72 156 835687 24921 89767683
Gastric polyps 13.85 9.72 82 835761 4590 89788014
Hyperlactacidaemia 13.85 9.72 75 835768 4061 89788543
Bezoar 13.85 9.72 4 835839 2730 89789874
Neutropenic sepsis 13.83 9.72 104 835739 18026 89774578
Stillbirth 13.81 9.72 30 835813 7413 89785191
Parkinsonism 13.81 9.72 194 835649 13871 89778733
Injection site discomfort 13.78 9.72 98 835745 5842 89786762
Resorption bone increased 13.78 9.72 33 835810 1186 89791418
Meningioma 13.77 9.72 87 835756 4984 89787620
Selective eating disorder 13.77 9.72 46 835797 2007 89790597
Osteonecrosis 13.74 9.72 328 835515 25913 89766691
Hypocholesterolaemia 13.70 9.72 24 835819 6425 89786179
Hypersensitivity vasculitis 13.65 9.72 75 835768 4084 89788520
Congenital aortic stenosis 13.65 9.72 7 835836 35 89792569
Hypoplastic left heart syndrome 13.64 9.72 13 835830 198 89792406
Eyelid ptosis 13.63 9.72 135 835708 8871 89783733
Familial periodic paralysis 13.57 9.72 12 835831 165 89792439
Akinesia 13.56 9.72 41 835802 1695 89790909
Eczema 13.56 9.72 607 835236 52263 89740341
Body height increased 13.56 9.72 9 835834 78 89792526
Dysaesthesia 13.56 9.72 89 835754 5166 89787438
Herpes zoster 13.54 9.72 1031 834812 93613 89698991
Upper gastrointestinal haemorrhage 13.53 9.72 292 835551 22684 89769920
Thyroid neoplasm 13.53 9.72 73 835770 3948 89788656
Photopsia 13.52 9.72 86 835757 4938 89787666
Occult blood positive 13.51 9.72 73 835770 3950 89788654
Decreased activity 13.49 9.72 125 835718 8067 89784537
Bradyphrenia 13.48 9.72 118 835725 7494 89785110
Drug level changed 13.48 9.72 13 835830 201 89792403
Fracture 13.47 9.72 282 835561 21794 89770810
Amyloid arthropathy 13.43 9.72 40 835803 1640 89790964
Product supply issue 13.43 9.72 59 835784 2933 89789671
Tri-iodothyronine increased 13.37 9.72 14 835829 240 89792364
Spinal fracture 13.35 9.72 281 835562 21735 89770869
Pneumonitis 13.35 9.72 516 835327 43654 89748950
Foetal chromosome abnormality 13.34 9.72 6 835837 21 89792583
Cerumen impaction 13.29 9.72 32 835811 1154 89791450
Anosognosia 13.27 9.72 8 835835 3514 89789090
Cortisol decreased 13.24 9.72 41 835802 1718 89790886
Vaccination site reaction 13.24 9.72 14 835829 243 89792361
Mitral valve disease 13.22 9.72 53 835790 2529 89790075
Product adhesion issue 13.22 9.72 87 835756 5055 89787549
Hyperchromic anaemia 13.19 9.72 9 835834 82 89792522
Rapid eye movement sleep behaviour disorder 13.17 9.72 17 835826 368 89792236
Senile osteoporosis 13.15 9.72 14 835829 245 89792359
Joint laxity 13.03 9.72 4 835839 2624 89789980
Electrocardiogram change 13.02 9.72 25 835818 769 89791835
Infrequent bowel movements 13.02 9.72 37 835806 1477 89791127
Supraventricular tachyarrhythmia 13.01 9.72 9 835834 84 89792520
Surgery 13.01 9.72 522 835321 44365 89748239
Arterial stenosis 12.98 9.72 24 835819 717 89791887
Exostosis of jaw 12.95 9.72 33 835810 1234 89791370
Mitral valve atresia 12.93 9.72 6 835837 23 89792581
Cardiac valve sclerosis 12.93 9.72 6 835837 23 89792581
Postural tremor 12.92 9.72 19 835824 467 89792137
Pancreatic disorder 12.89 9.72 58 835785 2913 89789691
Intestinal ischaemia 12.89 9.72 132 835711 8751 89783853
Calcium deficiency 12.88 9.72 34 835809 1299 89791305
Seasonal allergy 12.87 9.72 290 835553 22693 89769911
Adulterated product 12.86 9.72 17 835826 377 89792227
Parkinson's disease 12.85 9.72 30 835813 1060 89791544
Cholecystitis chronic 12.85 9.72 143 835700 9683 89782921
Total lung capacity decreased 12.84 9.72 69 835774 3726 89788878
Visual acuity reduced transiently 12.83 9.72 13 835830 214 89792390
Lumbosacral radiculopathy 12.83 9.72 21 835822 568 89792036
Adenoma benign 12.82 9.72 28 835815 946 89791658
Abortion spontaneous 12.79 9.72 390 835453 53666 89738938
Mandibular mass 12.79 9.72 12 835831 179 89792425
Hepatitis toxic 12.78 9.72 68 835775 3657 89788947
Tendon rupture 12.78 9.72 136 835707 9107 89783497
Paraesthesia oral 12.77 9.72 210 835633 31449 89761155
Lymph node palpable 12.76 9.72 10 835833 115 89792489
Mental impairment 12.74 9.72 221 835622 16499 89776105
Lipoma 12.74 9.72 58 835785 2928 89789676
Poor sucking reflex 12.72 9.72 18 835825 427 89792177
Retinal vein occlusion 12.71 9.72 52 835791 2504 89790100
Hypertonic bladder 12.69 9.72 76 835767 4272 89788332
Gastritis haemorrhagic 12.67 9.72 41 835802 1759 89790845
Ligament sprain 12.62 9.72 197 835646 14402 89778202
Interstitial lung disease 12.60 9.72 842 835001 75563 89717041
Thrombophlebitis 12.60 9.72 82 835761 4746 89787858
Disturbance in social behaviour 12.60 9.72 12 835831 4176 89788428
Vulvovaginitis 12.60 9.72 17 835826 385 89792219
Abnormal faeces 12.58 9.72 105 835738 6577 89786027
Pituitary cyst 12.57 9.72 4 835839 3 89792601
Nipple swelling 12.57 9.72 4 835839 3 89792601
Liver function test normal 12.57 9.72 4 835839 3 89792601
Rectal obstruction 12.57 9.72 4 835839 3 89792601
Cerebral cyst 12.53 9.72 15 835828 300 89792304
Hypokinesia 12.52 9.72 209 835634 15488 89777116
Sluggishness 12.51 9.72 96 835747 5863 89786741
Aortic intramural haematoma 12.48 9.72 10 835833 119 89792485
Heart valve calcification 12.47 9.72 5 835838 12 89792592
Shock haemorrhagic 12.47 9.72 170 835673 12075 89780529
Subcutaneous haematoma 12.46 9.72 42 835801 1841 89790763
Autoimmune dermatitis 12.45 9.72 11 835832 151 89792453
Lenticular opacities 12.45 9.72 14 835829 261 89792343
Skin fissures 12.43 9.72 265 835578 20544 89772060
Impatience 12.41 9.72 18 835825 437 89792167
Trigger finger 12.41 9.72 86 835757 5084 89787520
Antinuclear antibody increased 12.40 9.72 33 835810 1267 89791337
Throat tightness 12.38 9.72 358 835485 29126 89763478
Septic shock 12.34 9.72 642 835201 83518 89709086
Bifascicular block 12.34 9.72 10 835833 121 89792483
Hyperplastic cholecystopathy 12.34 9.72 11 835832 153 89792451
Transaminases increased 12.33 9.72 439 835404 36753 89755851
Renal cancer metastatic 12.30 9.72 15 835828 306 89792298
Cardiomegaly 12.29 9.72 244 835599 18681 89773923
Hyperventilation 12.28 9.72 105 835738 6623 89785981
Anal haemorrhage 12.28 9.72 51 835792 2473 89790131
Increased upper airway secretion 12.25 9.72 69 835774 3792 89788812
Ear discomfort 12.25 9.72 146 835697 10054 89782550
Skin dystrophy 12.25 9.72 7 835836 45 89792559
Mastication disorder 12.24 9.72 50 835793 2406 89790198
Primary hypothyroidism 12.22 9.72 11 835832 155 89792449
Blindness unilateral 12.22 9.72 117 835726 7619 89784985
Thyroiditis 12.21 9.72 66 835777 3571 89789033
Blood pressure diastolic decreased 12.18 9.72 329 835514 26497 89766107
Wrong product administered 12.14 9.72 116 835727 7549 89785055
Reaction to colouring 12.12 9.72 7 835836 46 89792558
Gastritis erosive 12.11 9.72 105 835738 6650 89785954
Acromegaly 12.11 9.72 9 835834 95 89792509
Product size issue 12.11 9.72 18 835825 447 89792157
Kidney infection 12.10 9.72 319 835524 25597 89767007
Nail toxicity 12.08 9.72 17 835826 401 89792203
Electrocardiogram T wave abnormal 12.06 9.72 53 835790 2635 89789969
Delusion 12.06 9.72 187 835656 13653 89778951
Overgrowth bacterial 12.05 9.72 11 835832 158 89792446
Phlebitis 12.05 9.72 113 835730 7317 89785287
Creatinine renal clearance increased 12.03 9.72 61 835782 3220 89789384
Oesophageal mass 12.00 9.72 7 835836 47 89792557
Narrow anterior chamber angle 12.00 9.72 7 835836 47 89792557
Stool analysis abnormal 12.00 9.72 7 835836 47 89792557
Insulin autoimmune syndrome 12.00 9.72 11 835832 159 89792445
Carcinoid tumour of the stomach 12.00 9.72 11 835832 159 89792445
Gallbladder obstruction 11.99 9.72 8 835835 70 89792534
Posterior reversible encephalopathy syndrome 11.94 9.72 140 835703 22199 89770405
Skin irritation 11.93 9.72 184 835659 13419 89779185
Systemic candida 11.91 9.72 17 835826 4942 89787662
Application site papules 11.90 9.72 8 835835 71 89792533
Carotid artery disease 11.90 9.72 38 835805 1619 89790985
Mixed liver injury 11.90 9.72 115 835728 7508 89785096
Abnormal behaviour 11.89 9.72 283 835560 22345 89770259
Tenosynovitis 11.87 9.72 82 835761 14485 89778119
Hepatojugular reflux 11.86 9.72 6 835837 29 89792575
Parathyroid gland enlargement 11.86 9.72 6 835837 29 89792575
Cervical spinal stenosis 11.86 9.72 52 835791 2583 89790021
Ear pain 11.83 9.72 424 835419 57278 89735326
Paralysis recurrent laryngeal nerve 11.81 9.72 8 835835 72 89792532
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 11.81 9.72 8 835835 72 89792532
Skin burning sensation 11.80 9.72 250 835593 19361 89773243
Neutrophil count 11.77 9.72 17 835826 411 89792193
Paradoxical drug reaction 11.76 9.72 22 835821 5744 89786860
Potentiating drug interaction 11.76 9.72 91 835752 5571 89787033
Polydipsia 11.75 9.72 73 835770 4158 89788446
Cataract operation 11.69 9.72 97 835746 6066 89786538
Type 3 diabetes mellitus 11.68 9.72 5 835838 15 89792589
Aortic valve disease 11.68 9.72 33 835810 1313 89791291
Venous occlusion 11.68 9.72 26 835817 890 89791714
Immune reconstitution inflammatory syndrome 11.66 9.72 30 835813 6989 89785615
Histamine intolerance 11.65 9.72 7 835836 50 89792554
Labyrinthitis 11.64 9.72 53 835790 2676 89789928
Cardiac flutter 11.64 9.72 78 835765 4560 89788044
Astrocytoma 11.63 9.72 8 835835 74 89792530
Application site pruritus 11.62 9.72 73 835770 4174 89788430
Foaming at mouth 11.62 9.72 33 835810 1317 89791287
Substance abuse 11.59 9.72 20 835823 5386 89787218
Intraocular pressure increased 11.56 9.72 108 835735 6985 89785619
Mitral valve prolapse 11.56 9.72 51 835792 2540 89790064
Premature labour 11.55 9.72 74 835769 13302 89779302
Eustachian tube obstruction 11.54 9.72 6 835837 31 89792573
Splenic haemorrhage 11.54 9.72 12 835831 204 89792400
Regurgitation 11.52 9.72 45 835798 2121 89790483
Auditory disorder 11.51 9.72 31 835812 1199 89791405
Acute sinusitis 11.51 9.72 73 835770 4188 89788416
Actinic keratosis 11.49 9.72 59 835784 3129 89789475
Eye haemorrhage 11.48 9.72 144 835699 10036 89782568
Arteriovenous malformation 11.48 9.72 36 835807 1519 89791085
Body temperature increased 11.47 9.72 319 835524 44391 89748213
Productive cough 11.45 9.72 842 835001 76221 89716383
Mucormycosis 11.43 9.72 11 835832 3810 89788794
Retroplacental haematoma 11.41 9.72 11 835832 170 89792434
Myocardial ischaemia 11.41 9.72 185 835658 13629 89778975
Vasculitis 11.38 9.72 282 835561 22411 89770193
White blood cell count decreased 11.37 9.72 1732 834111 165377 89627227
Muscle strain 11.34 9.72 138 835705 9549 89783055
Haematocrit decreased 11.33 9.72 483 835360 41349 89751255
Ultrasound abdomen abnormal 11.32 9.72 7 835836 53 89792551
Erythema of eyelid 11.31 9.72 60 835783 3223 89789381
Growth hormone deficiency 11.31 9.72 11 835832 172 89792432
Cerebral microangiopathy 11.28 9.72 14 835829 291 89792313
Drug specific antibody present 11.28 9.72 21 835822 5493 89787111
Adenomatous polyposis coli 11.28 9.72 10 835833 138 89792466
Hypomania 11.27 9.72 43 835800 8854 89783750
Bronchitis bacterial 11.24 9.72 27 835816 972 89791632
Hypoglossal nerve paralysis 11.23 9.72 5 835838 17 89792587
Neutrophil function disorder 11.23 9.72 5 835838 17 89792587
Poor feeding infant 11.22 9.72 19 835824 529 89792075
Instillation site reaction 11.21 9.72 18 835825 479 89792125
Abnormal loss of weight 11.18 9.72 104 835739 6719 89785885
Eye ulcer 11.18 9.72 17 835826 431 89792173
Tumour invasion 11.17 9.72 14 835829 294 89792310
Lacunar infarction 11.15 9.72 61 835782 3316 89789288
Bronchial wall thickening 11.12 9.72 44 835799 2087 89790517
Decerebration 11.11 9.72 7 835836 55 89792549
Foetal non-stress test abnormal 11.10 9.72 6 835837 34 89792570
Circulatory failure neonatal 11.09 9.72 3 835840 0 89792604
Thyroglobulin decreased 11.09 9.72 3 835840 0 89792604
Glaucomatous optic disc atrophy 11.09 9.72 3 835840 0 89792604
Mean platelet volume abnormal 11.09 9.72 3 835840 0 89792604
Benign enlargement of the subarachnoid spaces 11.09 9.72 3 835840 0 89792604
Primary hyperthyroidism 11.09 9.72 3 835840 0 89792604
Synovial cyst removal 11.09 9.72 3 835840 0 89792604
Biopsy colon 11.09 9.72 3 835840 0 89792604
Post stroke seizure 11.09 9.72 3 835840 0 89792604
Chemical burn of gastrointestinal tract 11.09 9.72 3 835840 0 89792604
Neurostimulator removal 11.09 9.72 3 835840 0 89792604
Calcium ionised abnormal 11.09 9.72 3 835840 0 89792604
Salivary gland mucocoele 11.09 9.72 3 835840 0 89792604
Neurologic somatic symptom disorder 11.09 9.72 3 835840 0 89792604
Spousal abuse 11.09 9.72 3 835840 0 89792604
Bronchial injury 11.09 9.72 3 835840 0 89792604
Clear cell sarcoma of soft tissue 11.09 9.72 3 835840 0 89792604
Gastrointestinal stoma necrosis 11.09 9.72 3 835840 0 89792604
Mucosal haemorrhage 11.06 9.72 34 835809 1419 89791185
Hyperkeratosis 11.05 9.72 105 835738 6823 89785781
Nephropathy toxic 11.05 9.72 70 835773 12618 89779986
Sexual dysfunction 11.02 9.72 17 835826 4787 89787817
Toe amputation 11.02 9.72 43 835800 2026 89790578
Neurosis 11.01 9.72 16 835827 389 89792215
Polyarthritis 11.01 9.72 112 835731 18238 89774366
Tooth extraction 10.98 9.72 158 835685 11355 89781249
Immune-mediated hepatitis 10.98 9.72 55 835788 2889 89789715
Slow speech 10.97 9.72 41 835802 1892 89790712
Tongue oedema 10.97 9.72 87 835756 5367 89787237
Blood urea nitrogen/creatinine ratio increased 10.95 9.72 29 835814 1110 89791494
Wrong patient received product 10.94 9.72 62 835781 3415 89789189
Diaphragmatic hernia 10.94 9.72 21 835822 646 89791958
Abdominal pain 10.93 9.72 3935 831908 391786 89400818
Pulmonary mass 10.91 9.72 345 835498 28427 89764177
Device use issue 10.90 9.72 65 835778 3648 89788956
Urine analysis abnormal 10.90 9.72 84 835759 5137 89787467
Seborrhoeic keratosis 10.88 9.72 58 835785 3122 89789482
Hypercapnic coma 10.86 9.72 13 835830 260 89792344
Anaemia vitamin B12 deficiency 10.83 9.72 21 835822 651 89791953
Enamel anomaly 10.81 9.72 5 835838 19 89792585
Periarthritis 10.81 9.72 56 835787 2981 89789623
Onychomalacia 10.80 9.72 4 835839 7 89792597
Respiratory fremitus 10.80 9.72 4 835839 7 89792597
Hair colour changes 10.80 9.72 62 835781 3432 89789172
Vein discolouration 10.78 9.72 14 835829 305 89792299
Neonatal tachypnoea 10.77 9.72 10 835833 147 89792457
Meniere's disease 10.77 9.72 11 835832 183 89792421
Deafness 10.77 9.72 278 835565 22236 89770368
Allergic reaction to excipient 10.77 9.72 23 835820 765 89791839
Atrioventricular block complete 10.73 9.72 138 835705 9673 89782931
Diffuse large B-cell lymphoma recurrent 10.73 9.72 10 835833 3516 89789088
Pancreatitis necrotising 10.73 9.72 47 835796 2334 89790270
Duodenal ulcer 10.72 9.72 135 835708 9417 89783187
Pituitary haemorrhage 10.72 9.72 8 835835 85 89792519
Steatorrhoea 10.72 9.72 19 835824 549 89792055
Lung neoplasm 10.71 9.72 102 835741 6633 89785971
Cheilitis 10.70 9.72 81 835762 4926 89787678
Hilar lymphadenopathy 10.69 9.72 32 835811 1316 89791288
Stasis dermatitis 10.69 9.72 26 835817 944 89791660
Idiosyncratic drug reaction 10.67 9.72 26 835817 945 89791659
Abortion induced 10.66 9.72 65 835778 11823 89780781
Nasal dryness 10.65 9.72 88 835755 5495 89787109
Acute hepatitis B 10.65 9.72 15 835828 354 89792250
Occupational exposure to product 10.64 9.72 5 835838 2526 89790078
Congenital muscle absence 10.61 9.72 5 835838 20 89792584
Degenerative mitral valve disease 10.61 9.72 5 835838 20 89792584
Trance 10.61 9.72 7 835836 60 89792544
Pulpitis dental 10.60 9.72 27 835816 1009 89791595
Urine chloride decreased 10.57 9.72 8 835835 87 89792517
Allergy to chemicals 10.57 9.72 65 835778 3689 89788915
Chromatopsia 10.55 9.72 18 835825 504 89792100
Melanoma recurrent 10.53 9.72 11 835832 188 89792416
Calcinosis 10.51 9.72 51 835792 2644 89789960
Haemorrhagic diathesis 10.50 9.72 87 835756 5437 89787167
Lymphopenia 10.50 9.72 281 835562 22600 89770004
Bronchopulmonary aspergillosis allergic 10.47 9.72 65 835778 3701 89788903
Postoperative thoracic procedure complication 10.46 9.72 4 835839 8 89792596
Oral neoplasm benign 10.46 9.72 4 835839 8 89792596
Solar dermatitis 10.45 9.72 10 835833 153 89792451
Blood iron abnormal 10.45 9.72 13 835830 4007 89788597
Nasal discharge discolouration 10.43 9.72 53 835790 2800 89789804
Acetabulum fracture 10.43 9.72 16 835827 409 89792195
Follicular thyroid cancer 10.42 9.72 7 835836 62 89792542
Delusional perception 10.42 9.72 12 835831 230 89792374
Hospice care 10.41 9.72 136 835707 9568 89783036
Sensory level abnormal 10.40 9.72 10 835833 154 89792450
Embedded device 10.39 9.72 71 835772 4177 89788427
Photosensitivity reaction 10.39 9.72 226 835617 17581 89775023
Frustration tolerance decreased 10.37 9.72 115 835728 7781 89784823
Gastrointestinal hypomotility 10.37 9.72 31 835812 1274 89791330
Drop attacks 10.35 9.72 21 835822 673 89791931
Carcinoembryonic antigen 10.35 9.72 8 835835 90 89792514
Temporomandibular joint syndrome 10.35 9.72 68 835775 3949 89788655
Arthralgia 10.33 9.72 6800 829043 771722 89020882
Deafness transitory 10.33 9.72 3 835840 2040 89790564
Hypogammaglobulinaemia 10.30 9.72 57 835786 10617 89781987
In vitro fertilisation 10.30 9.72 12 835831 233 89792371
Angiotensin converting enzyme increased 10.28 9.72 8 835835 91 89792513
Hypervitaminosis D 10.28 9.72 8 835835 91 89792513
Unintended pregnancy 10.27 9.72 36 835807 7601 89785003
Monocytosis 10.27 9.72 26 835817 968 89791636
Postictal paralysis 10.27 9.72 13 835830 276 89792328
Coating in mouth 10.26 9.72 11 835832 194 89792410
Soft tissue swelling 10.26 9.72 32 835811 1346 89791258
Pulmonary tuberculosis 10.26 9.72 18 835825 4816 89787788
Chronic fatigue syndrome 10.25 9.72 35 835808 1544 89791060
Rotator cuff syndrome 10.25 9.72 205 835638 15714 89776890
Radiation overdose 10.25 9.72 5 835838 22 89792582
Product contamination 10.25 9.72 29 835814 1155 89791449
Pancreatic cyst 10.24 9.72 44 835799 2166 89790438
Rheumatic disorder 10.22 9.72 60 835783 3348 89789256
Oral fungal infection 10.22 9.72 59 835784 3273 89789331
Rash pruritic 10.22 9.72 886 834957 81328 89711276
Bundle branch block 10.16 9.72 25 835818 914 89791690
Pneumatosis intestinalis 10.16 9.72 10 835833 3427 89789177
Application site swelling 10.16 9.72 20 835823 627 89791977
Gallbladder empyema 10.15 9.72 7 835836 65 89792539
Optic nerve compression 10.15 9.72 4 835839 9 89792595
Pulse pressure abnormal 10.15 9.72 4 835839 9 89792595
Complex regional pain syndrome 10.14 9.72 50 835793 2609 89789995
Vasodilatation 10.14 9.72 53 835790 2831 89789773
Sudden death 10.12 9.72 149 835694 10760 89781844
Skin warm 10.11 9.72 112 835731 7575 89785029
Hepatomegaly 10.11 9.72 176 835667 13150 89779454
Venoocclusive disease 10.09 9.72 5 835838 2450 89790154
Distributive shock 10.08 9.72 10 835833 3414 89789190
Phobia 10.08 9.72 15 835828 373 89792231
Corneal dystrophy 10.08 9.72 15 835828 373 89792231
Orbital swelling 10.06 9.72 7 835836 66 89792538
Anorectal malformation 10.06 9.72 12 835831 239 89792365
Acinetobacter infection 10.06 9.72 3 835840 2005 89790599
Scoliosis 10.05 9.72 126 835717 8781 89783823
Retinal vein thrombosis 10.04 9.72 18 835825 525 89792079
Tooth discolouration 10.03 9.72 29 835814 1169 89791435
Nasal polyps 10.01 9.72 59 835784 10821 89781783
Nephrolithiasis 9.98 9.72 551 835292 48534 89744070
Pelvic pain 9.97 9.72 198 835645 15159 89777445
IVth nerve paralysis 9.97 9.72 6 835837 43 89792561
Alanine aminotransferase abnormal 9.96 9.72 22 835821 5404 89787200
Adenoidal disorder 9.95 9.72 10 835833 163 89792441
Necrotising myositis 9.94 9.72 23 835820 808 89791796
Peripheral circulatory failure 9.94 9.72 35 835808 1569 89791035
Seroconversion test positive 9.91 9.72 5 835838 24 89792580
Umbilical hernia 9.91 9.72 63 835780 3617 89788987
SARS-CoV-2 test 9.91 9.72 5 835838 24 89792580
Product physical consistency issue 9.91 9.72 25 835818 929 89791675
Epinephrine increased 9.86 9.72 4 835839 10 89792594
Osteoma 9.86 9.72 6 835837 44 89792560
Strabismus 9.84 9.72 47 835796 2421 89790183
Cytomegalovirus chorioretinitis 9.83 9.72 5 835838 2414 89790190
Patella fracture 9.83 9.72 48 835795 2495 89790109
Upper motor neurone lesion 9.83 9.72 11 835832 204 89792400
Angioplasty 9.82 9.72 33 835810 1444 89791160
Small cell lung cancer 9.79 9.72 38 835805 1786 89790818
Arterial insufficiency 9.79 9.72 11 835832 205 89792399
Throat irritation 9.78 9.72 546 835297 48149 89744455
Parosmia 9.76 9.72 104 835739 6965 89785639
Dyslipidaemia 9.76 9.72 139 835704 9968 89782636
Maximal voluntary ventilation abnormal 9.75 9.72 5 835838 25 89792579
Lymphatic system neoplasm 9.75 9.72 6 835837 45 89792559
Ophthalmic vein thrombosis 9.74 9.72 14 835829 337 89792267

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypothyroidism 420.80 10.33 672 225791 31412 42363460
Drug ineffective 382.86 10.33 1889 224574 628308 41766564
Foetal exposure during pregnancy 317.39 10.33 746 225717 46565 42348307
Blood thyroid stimulating hormone increased 294.28 10.33 236 226227 5056 42389816
Drug abuse 257.62 10.33 117 226346 104654 42290218
Off label use 239.94 10.33 2206 224257 636129 41758743
Toxicity to various agents 218.90 10.33 566 225897 228570 42166302
Atrial septal defect 211.38 10.33 235 226228 7684 42387188
Febrile neutropenia 146.67 10.33 501 225962 185202 42209670
Fatigue 135.59 10.33 3146 223317 432495 41962377
Blood thyroid stimulating hormone decreased 130.02 10.33 104 226359 2219 42392653
Treatment failure 121.32 10.33 93 226370 62531 42332341
Craniopharyngioma 108.70 10.33 44 226419 222 42394650
Small for dates baby 105.53 10.33 135 226328 5128 42389744
Drug resistance 105.44 10.33 26 226437 34222 42360650
Neutropenia 98.35 10.33 638 225825 198793 42196079
Asthenia 87.73 10.33 2030 224433 278763 42116109
Myelosuppression 86.44 10.33 54 226409 40407 42354465
Drug ineffective for unapproved indication 85.09 10.33 72 226391 46091 42348781
Palmoplantar keratoderma 83.91 10.33 80 226383 2174 42392698
Cardiospasm 83.28 10.33 74 226389 1833 42393039
Pituitary tumour benign 81.11 10.33 56 226407 946 42393926
Thyroid disorder 80.27 10.33 102 226361 3848 42391024
Drug dependence 78.78 10.33 28 226435 29066 42365806
Thyroid function test abnormal 76.19 10.33 47 226416 649 42394223
Tension headache 75.53 10.33 92 226371 3322 42391550
Hyperthyroidism 74.12 10.33 205 226258 14136 42380736
Blood thyroid stimulating hormone abnormal 73.17 10.33 38 226425 368 42394504
Insulin-like growth factor increased 70.65 10.33 63 226400 1568 42393304
Bradycardia neonatal 70.48 10.33 58 226405 1290 42393582
Respiratory disorder neonatal 67.86 10.33 67 226396 1903 42392969
Adrenal insufficiency 67.66 10.33 238 226225 18686 42376186
Atrial tachycardia 67.46 10.33 96 226367 4044 42390828
Pruritus genital 66.48 10.33 76 226387 2563 42392309
Hypospadias 66.08 10.33 88 226375 3479 42391393
Anosmia 65.88 10.33 107 226356 5069 42389803
Thyroid cancer 65.84 10.33 63 226400 1720 42393152
Dehydration 64.81 10.33 1086 225377 140681 42254191
Infantile apnoea 63.88 10.33 51 226412 1085 42393787
Adrenocortical insufficiency acute 63.05 10.33 68 226395 2147 42392725
Disease progression 61.76 10.33 478 225985 143178 42251694
Sleep terror 61.75 10.33 77 226386 2849 42392023
Product use in unapproved indication 59.35 10.33 660 225803 183796 42211076
Appendicolith 58.99 10.33 3 226460 13453 42381419
Multiple organ dysfunction syndrome 58.83 10.33 290 226173 96745 42298127
Carotid artery occlusion 57.93 10.33 90 226373 4104 42390768
Large for dates baby 54.98 10.33 43 226420 887 42393985
Foetal megacystis 54.58 10.33 19 226444 57 42394815
Ventricular septal defect 53.38 10.33 89 226374 4310 42390562
Immunisation 53.32 10.33 48 226415 1210 42393662
Thyroxine free decreased 52.98 10.33 28 226435 282 42394590
Patent ductus arteriosus 52.84 10.33 78 226385 3398 42391474
Dizziness 52.73 10.33 1714 224749 247540 42147332
Therapy non-responder 51.43 10.33 131 226332 53228 42341644
Palpitations 51.04 10.33 452 226011 50345 42344527
Facial pain 48.79 10.33 84 226379 4176 42390696
Neurotoxicity 48.56 10.33 33 226430 23618 42371254
Chronic pigmented purpura 48.10 10.33 21 226442 132 42394740
Insulin-like growth factor decreased 47.28 10.33 25 226438 252 42394620
Bronchopulmonary aspergillosis 47.24 10.33 22 226441 19407 42375465
Decreased appetite 46.66 10.33 1350 225113 191787 42203085
Bone marrow failure 46.18 10.33 65 226398 33028 42361844
Thyrotoxic crisis 45.96 10.33 37 226426 797 42394075
Cytomegalovirus infection reactivation 44.61 10.33 4 226459 11174 42383698
Cytomegalovirus infection 44.54 10.33 64 226399 32242 42362630
Sedation 44.40 10.33 58 226405 30417 42364455
Leukopenia 43.24 10.33 227 226236 74519 42320353
Pituitary tumour recurrent 43.12 10.33 17 226446 79 42394793
Venoocclusive liver disease 43.03 10.33 3 226460 10299 42384573
Hypopituitarism 42.97 10.33 63 226400 2728 42392144
Autoimmune thyroiditis 42.31 10.33 47 226416 1535 42393337
Pneumocystis jirovecii pneumonia 42.00 10.33 43 226420 25138 42369734
Vasculitis 41.69 10.33 201 226262 18193 42376679
Cytokine release syndrome 41.62 10.33 111 226352 44416 42350456
Haematotoxicity 41.09 10.33 5 226458 10980 42383892
Urethral atresia 41.01 10.33 13 226450 26 42394846
Diabetes insipidus 40.95 10.33 72 226391 3641 42391231
Pyloric stenosis 40.50 10.33 36 226427 892 42393980
Poisoning 40.05 10.33 14 226449 14685 42380187
Fall 39.56 10.33 1572 224891 232948 42161924
Graft versus host disease 39.42 10.33 10 226453 12915 42381957
Vesicoureteric reflux 38.93 10.33 20 226443 189 42394683
Transient ischaemic attack 38.54 10.33 309 226154 33430 42361442
Migraine 38.43 10.33 249 226214 25165 42369707
Diplopia 37.72 10.33 210 226253 20106 42374766
Tinnitus 37.52 10.33 273 226190 28665 42366207
Sepsis 37.39 10.33 791 225672 198543 42196329
Diarrhoea 37.18 10.33 2885 223578 457964 41936908
Blood glucose increased 37.17 10.33 574 225889 73125 42321747
Pathogen resistance 36.61 10.33 8 226455 11442 42383430
Suicide attempt 36.57 10.33 124 226339 45976 42348896
Pericarditis 36.52 10.33 155 226308 13289 42381583
Cytomegalovirus viraemia 35.83 10.33 6 226457 10371 42384501
Drug reaction with eosinophilia and systemic symptoms 35.58 10.33 110 226353 41965 42352907
Infusion related reaction 35.54 10.33 184 226279 60622 42334250
Haemophagocytic lymphohistiocytosis 35.35 10.33 27 226436 18195 42376677
Neutrophil count decreased 35.34 10.33 195 226268 63220 42331652
Muscle twitching 35.31 10.33 140 226323 11640 42383232
Goitre 35.22 10.33 46 226417 1784 42393088
Palmar-plantar erythrodysaesthesia syndrome 35.10 10.33 208 226255 20374 42374498
Thyroid hormones decreased 34.98 10.33 17 226446 141 42394731
Thyroxine free increased 34.98 10.33 22 226441 315 42394557
Epiphysiolysis 34.62 10.33 16 226447 117 42394755
Myxoedema coma 34.55 10.33 20 226443 244 42394628
Tropical infectious disease 34.23 10.33 12 226451 37 42394835
Agitation neonatal 34.09 10.33 40 226423 1388 42393484
Overdose 34.07 10.33 376 226087 104888 42289984
Therapy partial responder 33.61 10.33 34 226429 19987 42374885
Appendicitis 33.48 10.33 36 226427 20577 42374295
Growth hormone deficiency 33.01 10.33 21 226442 307 42394565
Neonatal tachypnoea 32.94 10.33 22 226441 351 42394521
Pain of skin 32.75 10.33 106 226357 7974 42386898
Thyroxine decreased 32.08 10.33 18 226445 206 42394666
Total lung capacity abnormal 31.90 10.33 72 226391 4371 42390501
Tumour lysis syndrome 31.68 10.33 43 226420 22188 42372684
Dysphonia 31.65 10.33 259 226204 28191 42366681
Aspergillus infection 31.32 10.33 23 226440 15814 42379058
Substance abuse 31.08 10.33 5 226458 8900 42385972
Pulmonary vasculitis 30.83 10.33 88 226375 6178 42388694
Pulmonary artery stenosis 30.72 10.33 20 226443 305 42394567
Septic shock 30.65 10.33 325 226138 91347 42303525
Respiratory depression 30.59 10.33 33 226430 18835 42376037
BK virus infection 30.51 10.33 5 226458 8779 42386093
Hypophysitis 30.16 10.33 56 226407 2955 42391917
Conjunctivitis allergic 30.05 10.33 84 226379 5827 42389045
Potassium wasting nephropathy 29.61 10.33 13 226450 83 42394789
Drug hypersensitivity 29.45 10.33 362 226101 99027 42295845
Respiratory symptom 29.36 10.33 127 226336 10979 42383893
Transplant rejection 29.20 10.33 18 226445 13570 42381302
Pancytopenia 29.09 10.33 445 226018 117298 42277574
Drug intolerance 29.00 10.33 280 226183 80144 42314728
Toxic epidermal necrolysis 28.71 10.33 62 226401 26688 42368184
Disturbance in attention 28.58 10.33 263 226200 29603 42365269
Intercepted product preparation error 28.55 10.33 3 226460 7386 42387486
Weight decreased 28.40 10.33 1364 225099 206584 42188288
Blood testosterone decreased 28.28 10.33 73 226390 4829 42390043
Cerebrovascular accident 28.26 10.33 696 225767 96464 42298408
Blood growth hormone increased 28.14 10.33 25 226438 619 42394253
Macrocephaly 27.68 10.33 22 226441 465 42394407
Premature baby 27.52 10.33 214 226249 22939 42371933
Burns second degree 27.50 10.33 83 226380 6013 42388859
Cardiogenic shock 27.50 10.33 97 226366 35543 42359329
Neuritis 27.41 10.33 84 226379 6136 42388736
Neonatal behavioural syndrome 27.17 10.33 15 226448 166 42394706
Epstein-Barr virus infection 26.92 10.33 9 226454 9709 42385163
Infection 26.86 10.33 426 226037 111642 42283230
Anaphylactic reaction 26.31 10.33 127 226336 42616 42352256
Muscular weakness 26.06 10.33 604 225859 82894 42311978
Neutropenic sepsis 25.73 10.33 28 226435 15918 42378954
Blood thyroid stimulating hormone normal 25.46 10.33 6 226457 0 42394872
Immune reconstitution inflammatory syndrome 25.42 10.33 11 226452 10132 42384740
Mucosal inflammation 25.28 10.33 156 226307 49218 42345654
Post procedural hypothyroidism 24.93 10.33 9 226454 31 42394841
Diabetic foetopathy 24.83 10.33 15 226448 199 42394673
Cardiac septal hypertrophy 24.70 10.33 19 226444 382 42394490
Gingival pain 24.70 10.33 100 226363 8394 42386478
Selective eating disorder 24.57 10.33 38 226425 1726 42393146
Eosinophilic granulomatosis with polyangiitis 24.57 10.33 101 226362 8537 42386335
Papillary thyroid cancer 24.53 10.33 25 226438 738 42394134
Mycotic allergy 24.37 10.33 69 226394 4822 42390050
Parosmia 24.35 10.33 93 226370 7598 42387274
Thyroid cancer metastatic 24.31 10.33 10 226453 53 42394819
Growth hormone-producing pituitary tumour 24.17 10.33 13 226450 136 42394736
Glossodynia 24.13 10.33 62 226401 4090 42390782
Acute graft versus host disease in skin 24.12 10.33 5 226458 7419 42387453
Mite allergy 23.99 10.33 70 226393 4976 42389896
Neonatal asphyxia 23.89 10.33 20 226443 456 42394416
Catarrh 23.78 10.33 78 226385 5908 42388964
Metastatic renal cell carcinoma 23.77 10.33 42 226421 2132 42392740
Cardiac murmur 23.68 10.33 132 226331 12643 42382229
Adenovirus infection 23.37 10.33 4 226459 6805 42388067
Subarachnoid haemorrhage 23.25 10.33 144 226319 14328 42380544
Vertigo 23.24 10.33 282 226181 34065 42360807
General physical health deterioration 23.22 10.33 1004 225459 150242 42244630
Dry skin 23.05 10.33 373 226090 47965 42346907
Cytopenia 22.82 10.33 36 226427 17461 42377411
Mucormycosis 22.82 10.33 5 226458 7138 42387734
Thyroiditis 22.74 10.33 52 226411 3184 42391688
Painful respiration 22.68 10.33 32 226431 1337 42393535
Thrombocytopenia 22.68 10.33 805 225658 189474 42205398
Amnesia 22.63 10.33 241 226222 28196 42366676
Drug interaction 22.56 10.33 1174 225289 265825 42129047
Newborn persistent pulmonary hypertension 22.52 10.33 12 226451 123 42394749
Cerebral atrophy congenital 22.25 10.33 10 226453 68 42394804
Electrocardiogram QRS complex abnormal 22.23 10.33 19 226444 446 42394426
Thyroid hormones increased 21.96 10.33 11 226452 98 42394774
Congenital mitral valve incompetence 21.88 10.33 12 226451 131 42394741
Brain oedema 21.86 10.33 33 226430 16294 42378578
Flatulence 21.84 10.33 217 226246 24935 42369937
Aortic aneurysm 21.73 10.33 90 226373 7633 42387239
Pain in extremity 21.64 10.33 993 225470 149611 42245261
Nephropathy toxic 21.63 10.33 35 226428 16803 42378069
Hypoglycaemia neonatal 21.55 10.33 40 226423 2110 42392762
Dysgeusia 21.54 10.33 277 226186 33912 42360960
Alanine aminotransferase increased 21.53 10.33 335 226128 88071 42306801
Pulmonary valve stenosis congenital 21.49 10.33 12 226451 136 42394736
Spirometry abnormal 21.30 10.33 68 226395 5078 42389794
Systemic lupus erythematosus 21.21 10.33 102 226361 9222 42385650
Extrapyramidal disorder 21.19 10.33 34 226429 16378 42378494
Polycythaemia 20.98 10.33 47 226416 2839 42392033
C-reactive protein increased 20.97 10.33 226 226237 63334 42331538
Dust allergy 20.76 10.33 69 226394 5263 42389609
Hypopnoea 20.74 10.33 90 226373 7792 42387080
Blindness 20.72 10.33 165 226298 17813 42377059
Wrong patient 20.66 10.33 21 226442 618 42394254
Feeling abnormal 20.61 10.33 501 225962 69285 42325587
Full blood count abnormal 20.52 10.33 246 226217 29630 42365242
Walking aid user 20.41 10.33 44 226419 2589 42392283
Infective pulmonary exacerbation of cystic fibrosis 20.37 10.33 8 226455 7810 42387062
Serotonin syndrome 20.17 10.33 70 226393 25775 42369097
Congenital hydronephrosis 20.16 10.33 23 226440 774 42394098
Hypoacusis 20.13 10.33 169 226294 18533 42376339
Abdominal discomfort 20.09 10.33 533 225930 74722 42320150
Forced expiratory volume decreased 19.98 10.33 87 226376 7543 42387329
Normochromic normocytic anaemia 19.97 10.33 98 226365 8933 42385939
Eye pruritus 19.89 10.33 116 226347 11296 42383576
Haemangioma congenital 19.82 10.33 19 226444 520 42394352
Fractured coccyx 19.56 10.33 12 226451 164 42394708
Pituitary apoplexy 19.52 10.33 11 226452 127 42394745
Anencephaly 19.45 10.33 11 226452 128 42394744
Therapeutic product effect incomplete 19.30 10.33 263 226200 70676 42324196
Antineutrophil cytoplasmic antibody positive 19.28 10.33 59 226404 4306 42390566
Blood phosphorus increased 19.12 10.33 23 226440 12502 42382370
Drug level increased 19.10 10.33 73 226390 26127 42368745
Product use issue 18.97 10.33 290 226173 76461 42318411
Acute myeloid leukaemia 18.94 10.33 58 226405 22198 42372674
Hyponatraemia 18.94 10.33 688 225775 100774 42294098
Hepatic function abnormal 18.81 10.33 179 226284 51388 42343484
Neutrophil count increased 18.78 10.33 49 226414 19755 42375117
Exposure via breast milk 18.75 10.33 41 226422 2436 42392436
Secondary hypogonadism 18.73 10.33 22 226441 764 42394108
Thyroxine increased 18.65 10.33 10 226453 104 42394768
Immune-mediated hypothyroidism 18.53 10.33 28 226435 1246 42393626
Lip swelling 18.34 10.33 168 226295 18885 42375987
Capillaritis 18.16 10.33 38 226425 2190 42392682
Radiation inflammation 18.11 10.33 25 226438 1023 42393849
Lymphocyte count decreased 18.08 10.33 81 226382 27728 42367144
Pulmonary pain 17.92 10.33 31 226432 1547 42393325
Anaemia of malignant disease 17.90 10.33 18 226445 523 42394349
C-reactive protein abnormal 17.61 10.33 14 226449 9247 42385625
Aplastic anaemia 17.60 10.33 24 226439 12360 42382512
Anaphylactic shock 17.48 10.33 65 226398 23452 42371420
Epispadias 17.46 10.33 11 226452 158 42394714
Oedema peripheral 17.39 10.33 887 225576 135189 42259683
Gastric hypomotility 17.31 10.33 12 226451 204 42394668
Coagulation disorder neonatal 17.24 10.33 6 226457 18 42394854
Cardiotoxicity 17.24 10.33 9 226454 7436 42387436
Neonatal respiratory distress syndrome 17.21 10.33 58 226405 4455 42390417
Cognitive disorder 17.16 10.33 266 226197 33906 42360966
Syndactyly 17.14 10.33 23 226440 916 42393956
Forced vital capacity decreased 17.12 10.33 23 226440 917 42393955
Steroid dependence 17.11 10.33 76 226387 6646 42388226
Pseudomonas infection 17.01 10.33 37 226426 15886 42378986
Blood thyroid stimulating hormone 16.97 10.33 4 226459 0 42394872
Foetal heart rate deceleration abnormality 16.88 10.33 18 226445 561 42394311
Tri-iodothyronine increased 16.81 10.33 8 226455 63 42394809
Neonatal epileptic seizure 16.81 10.33 8 226455 63 42394809
Condition aggravated 16.80 10.33 1176 225287 259578 42135294
Brain natriuretic peptide abnormal 16.76 10.33 15 226448 375 42394497
Tri-iodothyronine decreased 16.73 10.33 10 226453 130 42394742
Neonatal pneumothorax 16.48 10.33 5 226458 8 42394864
Dependence on oxygen therapy 16.45 10.33 12 226451 222 42394650
Alopecia 16.31 10.33 232 226231 29044 42365828
Febrile bone marrow aplasia 16.29 10.33 18 226445 10163 42384709
Respiratory failure 16.20 10.33 538 225925 127594 42267278
Neonatal respiratory acidosis 16.20 10.33 8 226455 69 42394803
Neoplasm recurrence 16.17 10.33 41 226422 2683 42392189
Cardiac failure 16.09 10.33 708 225755 106148 42288724
Klebsiella infection 16.06 10.33 22 226441 11310 42383562
Rhythm idioventricular 16.02 10.33 14 226449 339 42394533
Pneumonia fungal 15.97 10.33 15 226448 9131 42385741
Hepatotoxicity 15.94 10.33 74 226389 25093 42369779
Urticaria 15.92 10.33 287 226176 73749 42321123
Lumbar puncture 15.89 10.33 9 226454 105 42394767
Chest discomfort 15.85 10.33 240 226223 63376 42331496
No adverse event 15.74 10.33 132 226331 38889 42355983
Incorrect route of product administration 15.68 10.33 71 226392 24234 42370638
Brain neoplasm 15.55 10.33 48 226415 3520 42391352
Swollen tongue 15.55 10.33 177 226286 21054 42373818
Ventricular fibrillation 15.51 10.33 95 226368 30028 42364844
Hypertension 15.48 10.33 1059 225404 166145 42228727
Urine oxalate increased 15.46 10.33 5 226458 11 42394861
Thyroidectomy 15.36 10.33 8 226455 78 42394794
Pyrexia 15.28 10.33 1847 224616 392195 42002677
Therapeutic product effect decreased 15.10 10.33 134 226329 39016 42355856
Memory impairment 14.96 10.33 361 226102 49861 42345011
Teething 14.93 10.33 8 226455 83 42394789
Pituitary tumour 14.92 10.33 17 226446 571 42394301
Atrial fibrillation 14.90 10.33 895 225568 138698 42256174
Shoulder dystocia 14.71 10.33 6 226457 31 42394841
Psychotic disorder 14.58 10.33 93 226370 29115 42365757
Dermatomyositis 14.55 10.33 29 226434 1614 42393258
Lymphopenia 14.51 10.33 62 226401 21501 42373371
Shunt malfunction 14.50 10.33 12 226451 269 42394603
Hypersensitivity 14.49 10.33 284 226179 72086 42322786
Ventricular tachycardia 14.47 10.33 233 226230 29927 42364945
Thrombotic microangiopathy 14.46 10.33 36 226427 14746 42380126
Hypothalamo-pituitary disorder 14.35 10.33 23 226440 1077 42393795
Blood uric acid increased 14.34 10.33 39 226424 15508 42379364
Ageusia 14.20 10.33 108 226355 11497 42383375
Hyponatraemic seizure 14.13 10.33 10 226453 176 42394696
Hyperbilirubinaemia neonatal 14.03 10.33 20 226443 844 42394028
Neurological symptom 13.96 10.33 96 226367 9895 42384977
N-terminal prohormone brain natriuretic peptide abnormal 13.94 10.33 11 226452 230 42394642
Primary hypothyroidism 13.93 10.33 8 226455 96 42394776
Interstitial lung disease 13.92 10.33 314 226149 78148 42316724
Coeliac disease 13.89 10.33 21 226442 935 42393937
Delirium 13.82 10.33 196 226267 52323 42342549
Unmasking of previously unidentified disease 13.77 10.33 24 226439 1205 42393667
Anti-thyroid antibody positive 13.73 10.33 7 226456 65 42394807
Osteochondroma 13.68 10.33 5 226458 18 42394854
Aorticopulmonary septal defect 13.68 10.33 5 226458 18 42394854
Hypersomnia 13.62 10.33 128 226335 14490 42380382
Vitello-intestinal duct remnant 13.61 10.33 9 226454 141 42394731
Oxygen saturation increased 13.61 10.33 12 226451 294 42394578
Liver injury 13.54 10.33 54 226409 19094 42375778
Endocrine ophthalmopathy 13.48 10.33 10 226453 190 42394682
Gastrooesophageal cancer 13.47 10.33 5 226458 19 42394853
Tongue movement disturbance 13.45 10.33 9 226454 144 42394728
Tracheal pain 13.45 10.33 6 226457 40 42394832
Rash papular 13.39 10.33 108 226355 11703 42383169
Intentional self-injury 13.38 10.33 39 226424 15163 42379709
Mineral deficiency 13.33 10.33 6 226457 41 42394831
Bicuspid aortic valve 13.28 10.33 12 226451 304 42394568
Maternal exposure during breast feeding 13.24 10.33 27 226436 1528 42393344
Aorta hypoplasia 13.19 10.33 8 226455 107 42394765
Urethral valves 13.17 10.33 11 226452 250 42394622
Alveolitis 13.14 10.33 30 226433 1835 42393037
Toxic neuropathy 13.11 10.33 16 226447 579 42394293
Blood prolactin decreased 13.09 10.33 11 226452 252 42394620
Sopor 13.04 10.33 32 226431 13170 42381702
Conduction disorder 13.01 10.33 36 226427 2482 42392390
Ankylosing spondylitis 13.00 10.33 11 226452 7045 42387827
Thyroxine abnormal 12.96 10.33 4 226459 7 42394865
Suicidal ideation 12.94 10.33 179 226284 47982 42346890
Lip discolouration 12.92 10.33 10 226453 203 42394669
Cardiac arrest 12.89 10.33 463 226000 108857 42286015
Cardiac hypertrophy 12.87 10.33 23 226440 1178 42393694
Intentional overdose 12.86 10.33 194 226269 51262 42343610
Gangrene neonatal 12.84 10.33 10 226453 205 42394667
Tachyarrhythmia 12.82 10.33 48 226415 3884 42390988
Growth retardation 12.80 10.33 35 226428 2397 42392475
Prescribed underdose 12.75 10.33 96 226367 10186 42384686
Wrong patient received product 12.75 10.33 45 226418 3538 42391334
Polyglandular autoimmune syndrome type II 12.73 10.33 3 226460 0 42394872
Neonatal thyrotoxicosis 12.73 10.33 3 226460 0 42394872
Posterior reversible encephalopathy syndrome 12.72 10.33 31 226432 12790 42382082
Hyperprolactinaemia 12.65 10.33 32 226431 2091 42392781
Hypoglycaemic seizure 12.64 10.33 13 226450 388 42394484
Chest injury 12.50 10.33 29 226434 1793 42393079
Enthesopathy 12.48 10.33 5 226458 4823 42390049
Hypogammaglobulinaemia 12.40 10.33 28 226435 11863 42383009
Lung disorder 12.38 10.33 338 226125 47585 42347287
Bacteraemia 12.36 10.33 80 226383 24960 42369912
Gait inability 12.34 10.33 180 226283 22653 42372219
Chiasma syndrome 12.31 10.33 4 226459 9 42394863
Cytomegalovirus colitis 12.29 10.33 3 226460 3978 42390894
Rhinitis 12.24 10.33 107 226356 11870 42383002
Product administered to patient of inappropriate age 12.19 10.33 5 226458 4756 42390116
Peripheral swelling 12.06 10.33 591 225872 89679 42305193
Optic nerve disorder 12.04 10.33 17 226446 711 42394161
Hospice care 12.02 10.33 82 226381 8431 42386441
Immunosuppressant drug level increased 12.01 10.33 14 226449 7717 42387155
Completed suicide 11.96 10.33 406 226057 96059 42298813
Seroma 11.95 10.33 16 226447 636 42394236
Fungal infection 11.90 10.33 59 226404 19663 42375209
Drug-induced liver injury 11.86 10.33 138 226325 38135 42356737
Chest pain 11.75 10.33 877 225586 138653 42256219
Hypotonia neonatal 11.73 10.33 25 226438 1459 42393413
Body height decreased 11.71 10.33 48 226415 4052 42390820
Bradycardia 11.70 10.33 561 225902 84923 42309949
Retrograde amnesia 11.62 10.33 10 226453 237 42394635
Brain cancer metastatic 11.59 10.33 8 226455 135 42394737
Application site inflammation 11.58 10.33 7 226456 93 42394779
Maternal exposure during pregnancy 11.57 10.33 70 226393 6908 42387964
Feeling jittery 11.56 10.33 51 226412 4447 42390425
Cytomegalovirus chorioretinitis 11.56 10.33 5 226458 4606 42390266
Cryptorchism 11.50 10.33 30 226433 1997 42392875
Empty sella syndrome 11.48 10.33 6 226457 59 42394813
Haemoglobinaemia 11.45 10.33 9 226454 187 42394685
Respiratory tract haemorrhage 11.45 10.33 24 226439 1385 42393487
Neuroleptic malignant syndrome 11.43 10.33 67 226396 21405 42373467
Blood immunoglobulin M abnormal 11.39 10.33 7 226456 96 42394776
Progressive multifocal leukoencephalopathy 11.36 10.33 28 226435 11508 42383364
Contraindicated product administered 11.36 10.33 83 226380 25189 42369683
Liposarcoma 11.30 10.33 8 226455 141 42394731
Oesophageal atresia 11.29 10.33 14 226449 515 42394357
Lymphadenopathy 11.26 10.33 118 226345 33247 42361625
Enterococcal infection 11.26 10.33 30 226433 12009 42382863
COVID-19 pneumonia 11.21 10.33 68 226395 21545 42373327
Neonatal respiratory failure 11.20 10.33 12 226451 376 42394496
Failure to thrive 11.15 10.33 87 226376 9335 42385537
Brachydactyly 11.13 10.33 9 226454 195 42394677
Joint effusion 11.11 10.33 9 226454 5888 42388984
Graft versus host disease in skin 11.07 10.33 7 226456 5205 42389667
Viral diarrhoea 11.07 10.33 11 226452 315 42394557
Type 1 diabetes mellitus 11.05 10.33 58 226405 5429 42389443
Neonatal respiratory distress 11.02 10.33 19 226444 946 42393926
Intercapillary glomerulosclerosis 10.98 10.33 6 226457 65 42394807
Escherichia infection 10.96 10.33 28 226435 11368 42383504
Pulmonary fibrosis 10.95 10.33 201 226262 26480 42368392
Bacterial infection 10.94 10.33 95 226368 27784 42367088
Therapeutic response decreased 10.88 10.33 135 226328 36877 42357995
Disseminated intravascular coagulation 10.87 10.33 82 226381 24712 42370160
Cervicogenic headache 10.82 10.33 4 226459 15 42394857
Protein total abnormal 10.78 10.33 12 226451 393 42394479
Miosis 10.77 10.33 36 226427 13410 42381462
Incision site swelling 10.75 10.33 6 226457 68 42394804
Tracheo-oesophageal fistula 10.74 10.33 14 226449 542 42394330
Behaviour disorder 10.72 10.33 13 226450 7041 42387831
Cholelithiasis 10.70 10.33 179 226284 23167 42371705
Atrioventricular block first degree 10.69 10.33 65 226398 6426 42388446
Bone erosion 10.68 10.33 5 226458 4398 42390474
Pulmonary arterial pressure abnormal 10.68 10.33 11 226452 329 42394543
CNS germinoma 10.67 10.33 3 226460 3 42394869
Pulmonary valve thickening 10.67 10.33 3 226460 3 42394869
Malignant melanoma stage IV 10.66 10.33 5 226458 38 42394834
Weight decrease neonatal 10.65 10.33 11 226452 330 42394542
Cortisol decreased 10.65 10.33 23 226440 1355 42393517
Desmoid tumour 10.63 10.33 7 226456 109 42394763
Thyroid mass 10.58 10.33 17 226446 798 42394074
Tracheal fistula 10.57 10.33 8 226455 157 42394715
Wrong schedule 10.54 10.33 11 226452 334 42394538
Syncope 10.54 10.33 637 225826 98769 42296103
Aggression 10.53 10.33 168 226295 43995 42350877
Altered state of consciousness 10.48 10.33 102 226361 29157 42365715
Product prescribing error 10.47 10.33 196 226267 25916 42368956
Glucose tolerance decreased 10.45 10.33 6 226457 72 42394800
Hypernatraemia 10.45 10.33 90 226373 9942 42384930
Hyperammonaemia 10.43 10.33 16 226447 7850 42387022
Skin indentation 10.43 10.33 4 226459 17 42394855
Congenital hand malformation 10.41 10.33 15 226448 639 42394233
Cranial sutures widening 10.41 10.33 7 226456 113 42394759
Hyperparathyroidism 10.41 10.33 22 226441 1277 42393595
Skin turgor decreased 10.37 10.33 14 226449 561 42394311
Moaning 10.37 10.33 18 226445 901 42393971
Scapula fracture 10.33 10.33 10 226453 277 42394595

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypothyroidism 948.85 10.06 1903 871504 70996 109644896
Blood thyroid stimulating hormone increased 829.56 10.06 725 872682 11576 109704316
Drug ineffective 803.92 10.06 7915 865492 1512625 108203267
Pemphigus 790.46 10.06 352 873055 214218 109501674
Synovitis 712.59 10.06 668 872739 273424 109442468
Systemic lupus erythematosus 642.35 10.06 636 872771 253702 109462190
Off label use 638.31 10.06 8199 865208 1491986 108223906
Hand deformity 634.95 10.06 478 872929 218028 109497864
Glossodynia 621.89 10.06 504 872903 221500 109494392
Anti-cyclic citrullinated peptide antibody positive 604.95 10.06 342 873065 181642 109534250
Infusion related reaction 601.26 10.06 1323 872084 379839 109336053
Treatment failure 572.17 10.06 813 872594 276421 109439471
Duodenal ulcer perforation 540.77 10.06 370 873037 177330 109538562
Drug intolerance 519.68 10.06 1569 871838 404943 109310949
Fall 505.07 10.06 7115 866292 596367 109119525
Contraindicated product administered 502.48 10.06 738 872669 247529 109468363
Helicobacter infection 490.79 10.06 428 872979 181449 109534443
Folliculitis 487.99 10.06 366 873041 167287 109548605
Pericarditis 456.58 10.06 638 872769 218476 109497416
Wound 443.75 10.06 729 872678 233708 109482184
Hyperthyroidism 417.27 10.06 794 872613 28467 109687425
Palpitations 406.31 10.06 2395 871012 156817 109559075
Arthropathy 396.47 10.06 1070 872337 286452 109429440
Muscle injury 386.39 10.06 326 873081 140481 109575411
Hepatic enzyme increased 372.07 10.06 1293 872114 319599 109396293
Blood thyroid stimulating hormone decreased 352.30 10.06 356 873051 6883 109709009
Myelosuppression 351.66 10.06 152 873255 94188 109621704
Therapeutic product effect decreased 335.44 10.06 911 872496 243405 109472487
Febrile neutropenia 326.56 10.06 1339 872068 315428 109400464
Irritable bowel syndrome 320.72 10.06 500 872907 163715 109552177
Facet joint syndrome 304.81 10.06 194 873213 96634 109619258
Impaired healing 304.01 10.06 690 872717 196027 109519865
Product use in unapproved indication 297.26 10.06 2189 871218 445188 109270704
Drug abuse 296.06 10.06 596 872811 176815 109539077
Toxicity to various agents 288.76 10.06 2417 870990 478138 109237754
Rheumatoid factor positive 285.59 10.06 372 873035 131268 109584624
Swelling 271.60 10.06 1641 871766 349400 109366492
Maternal exposure during pregnancy 262.27 10.06 1078 872329 253805 109462087
Hyponatraemia 261.27 10.06 2749 870658 214904 109500988
Rheumatic fever 261.21 10.06 351 873056 122228 109593664
Lower respiratory tract infection 258.47 10.06 1015 872392 242091 109473801
Hypersensitivity 257.32 10.06 2000 871407 401998 109313894
Joint swelling 254.11 10.06 2254 871153 440591 109275301
Breast cancer stage III 252.50 10.06 156 873251 78961 109636931
Drug hypersensitivity 251.95 10.06 2331 871076 451759 109264133
Feeling abnormal 251.13 10.06 2353 871054 178358 109537534
Ill-defined disorder 250.69 10.06 540 872867 156313 109559579
Fatigue 247.34 10.06 11850 861557 1204108 108511784
Blood thyroid stimulating hormone normal 242.13 10.06 73 873334 52 109715840
Thyroid disorder 237.69 10.06 457 872950 16512 109699380
Cognitive disorder 230.67 10.06 1328 872079 86183 109629709
Drug resistance 229.70 10.06 79 873328 56295 109659597
Asthenia 229.02 10.06 7089 866318 681910 109033982
Sleep disorder due to general medical condition, insomnia type 227.65 10.06 300 873107 105343 109610549
Psoriatic arthropathy 226.47 10.06 795 872612 195966 109519926
Onychomadesis 217.92 10.06 47 873360 45616 109670276
Stomatitis 212.27 10.06 1257 872150 268985 109446907
Balance disorder 211.39 10.06 1611 871796 114949 109600943
Blood thyroid stimulating hormone abnormal 208.71 10.06 123 873284 1006 109714886
Thyroid function test abnormal 204.35 10.06 187 873220 3180 109712712
Dizziness 200.99 10.06 7063 866344 691130 109024762
Blister 200.87 10.06 1017 872390 226359 109489533
Lip dry 198.96 10.06 301 873106 99782 109616110
Myalgia 197.66 10.06 2652 870755 219729 109496163
Blepharospasm 192.61 10.06 96 873311 54755 109661137
Liver injury 192.31 10.06 580 872827 149833 109566059
Drug ineffective for unapproved indication 189.66 10.06 325 873082 102513 109613379
C-reactive protein abnormal 186.78 10.06 472 872935 129223 109586669
Dehydration 185.52 10.06 3171 870236 276340 109439552
Infection 184.50 10.06 1898 871509 360302 109355590
Discomfort 183.09 10.06 972 872435 213735 109502157
Headache 180.78 10.06 8608 864799 873769 108842123
Hypercholesterolaemia 178.83 10.06 275 873132 90562 109625330
Nausea 178.41 10.06 11672 861735 1224018 108491874
Vertigo 177.23 10.06 1235 872172 85635 109630257
Bursitis 170.41 10.06 495 872912 129423 109586469
Type 2 diabetes mellitus 163.85 10.06 780 872627 176452 109539440
Joint range of motion decreased 163.61 10.06 459 872948 121373 109594519
C-reactive protein increased 163.07 10.06 1029 872378 216890 109499002
Peripheral venous disease 162.41 10.06 258 873149 83859 109632033
Product substitution issue 161.55 10.06 474 872933 22587 109693305
Adrenocortical insufficiency acute 161.09 10.06 187 873220 4253 109711639
Cytomegalovirus infection 159.46 10.06 118 873289 54326 109661566
Diarrhoea 159.07 10.06 10734 862673 1128771 108587121
Orthostatic hypotension 155.84 10.06 976 872431 65273 109650619
Wound infection 155.03 10.06 331 873076 96134 109619758
Product prescribing error 152.70 10.06 805 872602 50526 109665366
Creatinine renal clearance decreased 151.50 10.06 447 872960 21368 109694524
Blood pressure increased 149.87 10.06 2870 870537 255503 109460389
Blood calcium decreased 148.42 10.06 619 872788 35226 109680666
Inflammation 147.40 10.06 907 872500 192331 109523561
Constipation 147.25 10.06 3784 869623 354002 109361890
Onychomycosis 146.92 10.06 60 873347 38471 109677421
Disturbance in attention 144.37 10.06 911 872496 61084 109654808
Transient ischaemic attack 138.48 10.06 923 872484 63059 109652833
Multiple organ dysfunction syndrome 137.14 10.06 673 872734 151037 109564855
Therapy non-responder 136.97 10.06 707 872700 156600 109559292
Nail disorder 135.91 10.06 154 873253 57781 109658111
Urinary tract infection 134.59 10.06 3452 869955 322830 109393062
Atrial fibrillation 133.90 10.06 2553 870854 227089 109488803
Sedation complication 133.29 10.06 402 873005 19453 109696439
Syncope 129.74 10.06 2285 871122 200251 109515641
Exposure during pregnancy 123.99 10.06 793 872614 166631 109549261
Craniopharyngioma 123.18 10.06 60 873347 317 109715575
Swollen joint count increased 123.15 10.06 301 873106 83360 109632532
Blood glucose increased 123.04 10.06 1593 871814 130903 109584989
Product use issue 121.43 10.06 1731 871676 309964 109405928
Transplant rejection 115.78 10.06 26 873381 24541 109691351
Back injury 115.60 10.06 122 873285 47277 109668615
Thyrotoxic crisis 115.51 10.06 109 873298 1931 109713961
Cerebrovascular accident 114.95 10.06 2042 871365 179242 109536650
Dry skin 114.55 10.06 1328 872079 106325 109609567
Vision blurred 113.89 10.06 1537 871870 127485 109588407
Obesity 113.66 10.06 484 872923 112867 109603025
Neutropenia 112.29 10.06 2183 871224 372437 109343455
Disease progression 112.13 10.06 1309 872098 242725 109473167
Grip strength decreased 109.91 10.06 299 873108 79875 109636017
Dislocation of vertebra 108.36 10.06 111 873296 43610 109672282
Anxiety 107.90 10.06 3526 869881 341552 109374340
Cytokine release syndrome 107.42 10.06 248 873159 70058 109645834
Hot flush 106.73 10.06 889 872518 65147 109650745
Dysgeusia 106.19 10.06 929 872478 69056 109646836
Tremor 106.08 10.06 2213 871194 200019 109515873
Finger deformity 105.93 10.06 65 873342 33027 109682865
Palmoplantar keratoderma 105.29 10.06 168 873239 5219 109710673
Bone erosion 104.76 10.06 127 873280 46244 109669648
Hepatic function abnormal 104.58 10.06 358 873049 88937 109626955
Coeliac disease 104.39 10.06 112 873295 43075 109672817
Cardiospasm 104.16 10.06 160 873247 4807 109711085
Anosmia 103.82 10.06 273 873134 12199 109703693
Abdominal discomfort 102.84 10.06 2347 871060 391511 109324381
Sensitisation 101.89 10.06 144 873263 4007 109711885
Intentional product use issue 101.45 10.06 1363 872044 246543 109469349
Dysphagia 100.17 10.06 1738 871669 151862 109564030
Product label confusion 99.15 10.06 28 873379 22649 109693243
Appendicolith 98.71 10.06 3 873404 14252 109701640
Injury 97.69 10.06 911 872496 176354 109539538
Musculoskeletal stiffness 96.03 10.06 1592 871815 278230 109437662
Bone marrow failure 95.04 10.06 196 873211 57652 109658240
Toxic epidermal necrolysis 94.22 10.06 191 873216 56536 109659356
Gastrointestinal disorder 93.04 10.06 1347 872060 240605 109475287
Full blood count abnormal 92.41 10.06 758 872649 55294 109660598
Cytomegalovirus infection reactivation 91.38 10.06 17 873390 18316 109697576
Tension headache 90.99 10.06 221 873186 9397 109706495
Pruritus genital 90.55 10.06 175 873232 6347 109709545
Fibromyalgia 90.50 10.06 887 872520 170022 109545870
Drug use disorder 89.58 10.06 17 873390 18057 109697835
Atrial tachycardia 89.09 10.06 213 873194 8965 109706927
Carotid artery occlusion 88.59 10.06 218 873189 9347 109706545
Autoimmune thyroiditis 88.55 10.06 172 873235 6262 109709630
Retinitis 88.46 10.06 75 873332 32252 109683640
Taste disorder 88.03 10.06 246 873161 65141 109650751
Sleep terror 87.69 10.06 174 873233 6436 109709456
Pyrexia 85.63 10.06 6025 867382 892240 108823652
Therapeutic product effect incomplete 84.30 10.06 1251 872156 222554 109493338
Insulin-like growth factor increased 83.80 10.06 97 873310 2199 109713693
Completed suicide 83.15 10.06 1379 872028 241002 109474890
Wheezing 83.07 10.06 1466 871941 253764 109462128
Haemophagocytic lymphohistiocytosis 83.00 10.06 76 873331 31483 109684409
Back pain 82.95 10.06 3653 869754 367343 109348549
Venoocclusive liver disease 82.81 10.06 11 873396 15196 109700696
Lip swelling 82.36 10.06 683 872724 49984 109665908
Dyspnoea 81.92 10.06 9959 863448 1096913 108618979
Thyroid cancer 81.74 10.06 163 873244 6051 109709841
Myxoedema coma 81.37 10.06 57 873350 645 109715247
Night sweats 81.14 10.06 672 872735 133311 109582581
Tinnitus 80.91 10.06 782 872625 59758 109656134
Hypoglycaemia 80.90 10.06 1328 872079 114776 109601116
Influenza like illness 80.40 10.06 1059 872348 87353 109628539
Neurotoxicity 80.01 10.06 131 873276 42076 109673816
Product complaint 79.29 10.06 267 873140 13705 109702187
Facial pain 79.13 10.06 284 873123 15055 109700837
Thyroxine free increased 78.98 10.06 76 873331 1381 109714511
Post transplant lymphoproliferative disorder 78.86 10.06 14 873393 15599 109700293
Pathogen resistance 78.80 10.06 21 873386 17651 109698241
Diplopia 78.72 10.06 584 872823 41310 109674582
Bronchopulmonary aspergillosis 78.44 10.06 72 873335 29791 109686101
Bone pain 78.23 10.06 823 872584 64310 109651582
Epilepsy 77.09 10.06 469 872938 99740 109616152
Neutrophil count decreased 76.73 10.06 599 872808 120342 109595550
Carpal tunnel syndrome 75.97 10.06 367 873040 22243 109693649
Cytomegalovirus viraemia 75.71 10.06 23 873384 17741 109698151
Thyroidectomy 75.39 10.06 66 873341 1056 109714836
Live birth 75.13 10.06 288 873119 69196 109646696
Pituitary tumour benign 74.73 10.06 102 873305 2745 109713147
Immunisation 73.12 10.06 107 873300 3076 109712816
Septic shock 73.10 10.06 843 872564 156685 109559207
Condition aggravated 72.91 10.06 4911 868496 729925 108985967
Cystitis haemorrhagic 71.07 10.06 7 873400 12202 109703690
Eating disorder 70.94 10.06 452 872955 30406 109685486
Product dose omission issue 70.94 10.06 3164 870243 318618 109397274
Adjustment disorder with depressed mood 70.14 10.06 151 873256 43732 109672160
Polycystic ovaries 69.43 10.06 131 873276 4665 109711227
Oedema peripheral 68.20 10.06 3212 870195 325448 109390444
Sleep disorder 68.18 10.06 1130 872277 197514 109518378
Thyroid hormones decreased 68.17 10.06 51 873356 644 109715248
Haematotoxicity 68.05 10.06 41 873366 21041 109694851
Eye irritation 67.28 10.06 474 872933 32978 109682914
Adverse event 67.13 10.06 543 872864 108266 109607626
Angina pectoris 66.94 10.06 770 872637 61525 109654367
Granuloma skin 66.93 10.06 6 873401 11277 109704615
Therapeutic drug monitoring analysis not performed 66.20 10.06 79 873328 1852 109714040
Alopecia 66.09 10.06 2287 871120 362466 109353426
Ejection fraction 65.96 10.06 98 873309 2857 109713035
Aspergillus infection 65.82 10.06 63 873344 25553 109690339
Thyroid hormones increased 65.58 10.06 47 873360 553 109715339
Cystitis 65.14 10.06 803 872604 65233 109650659
Panniculitis 64.94 10.06 21 873386 15561 109700331
Pituitary tumour recurrent 64.69 10.06 31 873376 157 109715735
Red blood cell sedimentation rate abnormal 64.48 10.06 59 873348 24450 109691442
Pneumocystis jirovecii pneumonia 64.28 10.06 152 873255 42583 109673309
Gestational diabetes 63.82 10.06 164 873243 7225 109708667
Skin haemorrhage 63.61 10.06 374 873033 24453 109691439
Arterial occlusive disease 63.09 10.06 264 873143 15044 109700848
Sepsis 62.93 10.06 2037 871370 325309 109390583
Flatulence 62.65 10.06 659 872748 51490 109664402
Drug-induced liver injury 61.94 10.06 627 872780 119440 109596452
Adverse reaction 61.76 10.06 86 873321 29508 109686384
Therapeutic response unexpected 61.62 10.06 360 873047 23483 109692409
Pain in extremity 61.58 10.06 4554 868853 482564 109233328
BK virus infection 61.50 10.06 14 873393 13092 109702800
Mucosal inflammation 61.06 10.06 476 872931 95665 109620227
Incorrect route of product administration 60.91 10.06 279 873128 63782 109652110
Foreign body in reproductive tract 60.88 10.06 55 873352 919 109714973
Eye pruritus 60.52 10.06 455 872952 32320 109683572
Oral pain 59.92 10.06 503 872904 36941 109678951
Hip fracture 59.92 10.06 479 872928 34672 109681220
Adenovirus infection 59.76 10.06 8 873399 10986 109704906
Cataract 59.45 10.06 920 872487 78565 109637327
Overdose 59.33 10.06 1399 872008 232395 109483497
Product monitoring error 59.22 10.06 180 873227 8747 109707145
Cough 59.05 10.06 4320 869087 457321 109258571
Therapy partial responder 58.84 10.06 128 873279 36933 109678959
Chronic sinusitis 58.48 10.06 67 873340 25017 109690875
Neurologic neglect syndrome 58.46 10.06 184 873223 9114 109706778
Female genital tract fistula 57.86 10.06 29 873378 16490 109699402
Systemic infection 57.82 10.06 190 873217 9629 109706263
Product formulation issue 56.66 10.06 61 873346 1273 109714619
Weight decreased 56.51 10.06 4360 869047 463697 109252195
Intentional overdose 56.18 10.06 723 872684 131778 109584114
Prescribed overdose 55.91 10.06 433 872974 87148 109628744
Malaise 55.78 10.06 6091 867316 665728 109050164
Temperature regulation disorder 55.77 10.06 16 873391 12810 109703082
Bradycardia 55.71 10.06 1616 871791 153901 109561991
Muscle twitching 54.95 10.06 415 872992 29520 109686372
Multiple-drug resistance 54.87 10.06 18 873389 13217 109702675
Graft versus host disease 54.76 10.06 41 873366 18765 109697127
Hepatotoxicity 54.57 10.06 286 873121 63114 109652778
Aplastic anaemia 54.46 10.06 67 873340 24241 109691651
Reaction to excipient 54.39 10.06 74 873333 1985 109713907
Blood cholesterol increased 54.33 10.06 1080 872327 183705 109532187
Dysphonia 54.20 10.06 872 872535 75057 109640835
Thrombotic microangiopathy 53.84 10.06 92 873315 29057 109686835
Burning sensation 53.27 10.06 805 872602 68407 109647485
Reversible airways obstruction 53.11 10.06 81 873326 2418 109713474
Thyroxine increased 52.72 10.06 51 873356 933 109714959
Polyomavirus-associated nephropathy 52.56 10.06 3 873404 8198 109707694
Device adhesion issue 52.50 10.06 6 873401 9304 109706588
Head injury 52.34 10.06 545 872862 42472 109673420
Papillary thyroid cancer 52.15 10.06 87 873320 2807 109713085
Pancytopenia 51.34 10.06 1261 872146 208352 109507540
Chronic graft versus host disease 51.12 10.06 7 873400 9450 109706442
Carotid artery thrombosis 51.04 10.06 180 873227 9458 109706434
Tumour lysis syndrome 50.90 10.06 104 873303 30697 109685195
Drug tolerance decreased 50.80 10.06 87 873320 27453 109688439
Subarachnoid haemorrhage 50.76 10.06 405 873002 29297 109686595
Tenderness 50.65 10.06 402 873005 29035 109686857
Affect lability 50.52 10.06 285 873122 18352 109697540
Thyroxine free decreased 50.44 10.06 55 873352 1165 109714727
Infective pulmonary exacerbation of cystic fibrosis 50.15 10.06 27 873380 14744 109701148
Visual impairment 50.13 10.06 1404 872003 133024 109582868
Substance abuse 49.85 10.06 18 873389 12445 109703447
Nervousness 49.72 10.06 477 872930 36374 109679518
Acute graft versus host disease in skin 49.36 10.06 12 873395 10728 109705164
Hypoacusis 49.22 10.06 459 872948 34732 109681160
Blood parathyroid hormone decreased 48.91 10.06 21 873386 13068 109702824
Liver function test increased 48.79 10.06 455 872952 88093 109627799
Rheumatoid nodule 48.64 10.06 53 873354 20243 109695649
Poisoning 48.33 10.06 98 873309 29007 109686885
Epstein-Barr virus infection 48.24 10.06 46 873361 18692 109697200
Blindness 47.77 10.06 468 872939 35891 109680001
Diffuse alopecia 47.55 10.06 56 873351 1294 109714598
Blood thyroid stimulating hormone 47.36 10.06 13 873394 3 109715889
Hypotension 46.90 10.06 4774 868633 519075 109196817
Red blood cell sedimentation rate increased 46.82 10.06 394 873013 77908 109637984
Aphasia 45.71 10.06 687 872720 58310 109657582
Tri-iodothyronine decreased 45.69 10.06 32 873375 362 109715530
Coordination abnormal 45.33 10.06 348 873059 24880 109691012
Sickle cell anaemia with crisis 45.19 10.06 10 873397 9535 109706357
Insulin-like growth factor decreased 45.14 10.06 38 873369 575 109715317
Porphyria acute 45.06 10.06 49 873358 18731 109697161
Lupus vulgaris 44.48 10.06 129 873278 33754 109682138
Multiple drug therapy 44.47 10.06 152 873255 7862 109708030
Disorientation 44.39 10.06 795 872612 69876 109646016
Haematoma 44.18 10.06 678 872729 57798 109658094
Sneezing 44.15 10.06 416 872991 31568 109684324
Chest pain 44.09 10.06 3498 869909 372877 109343015
Gait disturbance 43.86 10.06 2650 870757 275558 109440334
X-ray abnormal 43.83 10.06 154 873253 37963 109677929
Arrhythmia 43.82 10.06 783 872624 68792 109647100
Injection site reaction 43.55 10.06 471 872936 88599 109627293
Pulmonary malformation 43.48 10.06 26 873381 219 109715673
Anaphylactic reaction 43.33 10.06 638 872769 113662 109602230
Graft versus host disease in gastrointestinal tract 43.26 10.06 9 873398 8959 109706933
Mucormycosis 43.11 10.06 15 873392 10613 109705279
Gangrene 43.05 10.06 248 873159 16093 109699799
Thrombocytopenia 42.78 10.06 2285 871122 346600 109369292
Hypopituitarism 42.74 10.06 102 873305 4288 109711604
Sinus congestion 42.46 10.06 397 873010 30062 109685830
Vital capacity decreased 42.38 10.06 66 873341 2007 109713885
Ageusia 42.26 10.06 283 873124 19362 109696530
Urticaria 42.22 10.06 2072 871335 316785 109399107
Blood growth hormone increased 42.17 10.06 47 873360 1021 109714871
Seronegative arthritis 42.01 10.06 26 873381 13151 109702741
Proctitis 41.92 10.06 43 873364 16884 109699008
Nephropathy toxic 41.91 10.06 97 873310 27381 109688511
Nocardiosis 41.77 10.06 5 873402 7481 109708411
Immune reconstitution inflammatory syndrome 41.58 10.06 40 873367 16186 109699706
Pain of skin 41.57 10.06 286 873121 19743 109696149
Decreased appetite 41.51 10.06 4329 869078 471517 109244375
Drug dependence 41.19 10.06 229 873178 49791 109666101
Rash papular 40.94 10.06 365 873042 27274 109688618
Sinus disorder 40.93 10.06 417 872990 32311 109683581
Cardio-respiratory arrest 40.70 10.06 656 872751 115180 109600712
Prostate cancer 40.70 10.06 156 873251 37485 109678407
Atrioventricular block 40.53 10.06 250 873157 16627 109699265
Jaw disorder 40.28 10.06 111 873296 5101 109710791
Complication of device insertion 40.07 10.06 157 873250 8681 109707211
Chest discomfort 39.95 10.06 1717 871690 172131 109543761
Lupus-like syndrome 39.77 10.06 176 873231 40616 109675276
Myxoedema 39.63 10.06 25 873382 234 109715658
Intercepted product preparation error 39.46 10.06 4 873403 6816 109709076
Transplant dysfunction 38.87 10.06 9 873398 8319 109707573
Eye pain 38.67 10.06 583 872824 49516 109666376
Diabetes insipidus 38.57 10.06 127 873280 6443 109709449
Dyspnoea exertional 38.56 10.06 1086 872321 102974 109612918
Muscle spasms 38.47 10.06 2620 870787 275537 109440355
Spinal stenosis 38.31 10.06 270 873137 18786 109697106
Infusion site reaction 38.30 10.06 50 873357 17632 109698260
Gallbladder disorder 38.30 10.06 291 873116 20738 109695154
Maternal exposure timing unspecified 38.19 10.06 67 873340 20946 109694946
Hyperhidrosis 38.08 10.06 1827 871580 185471 109530421
Exostosis 38.06 10.06 210 873197 45746 109670146
Skin exfoliation 38.05 10.06 934 872473 86717 109629175
Enthesopathy 37.91 10.06 26 873381 12452 109703440
Respiratory failure 37.62 10.06 1356 872051 213976 109501916
Adjustment disorder 37.56 10.06 177 873230 10618 109705274
Neutropenic sepsis 37.55 10.06 121 873286 30625 109685267
Palmar-plantar erythrodysaesthesia syndrome 37.54 10.06 492 872915 40533 109675359
Gastritis 37.32 10.06 614 872793 53085 109662807
Personality disorder 37.27 10.06 200 873207 12637 109703255
Haemorrhoids 37.02 10.06 438 872969 35234 109680658
Blood glucose decreased 37.02 10.06 376 873031 29112 109686780
Multiple allergies 36.93 10.06 193 873214 12070 109703822
Hypophysitis 36.69 10.06 110 873297 5305 109710587
Drug reaction with eosinophilia and systemic symptoms 36.66 10.06 443 872964 81652 109634240
Malabsorption 36.65 10.06 123 873284 6302 109709590
Liver function test abnormal 36.61 10.06 756 872651 68194 109647698
Vasculitis 36.58 10.06 439 872968 35434 109680458
Gait inability 36.57 10.06 809 872598 135567 109580325
Ischaemic stroke 36.57 10.06 492 872915 40771 109675121
Graft versus host disease in skin 36.44 10.06 10 873397 8244 109707648
Foetal death 36.18 10.06 44 873363 16001 109699891
Pemphigoid 36.05 10.06 273 873134 19434 109696458
Rash 36.00 10.06 5815 867592 815149 108900743
Pseudomonas infection 35.87 10.06 107 873300 27746 109688146
Eye swelling 35.73 10.06 409 872998 32639 109683253
Disseminated intravascular coagulation 35.67 10.06 186 873221 41100 109674792
Goitre 35.60 10.06 119 873288 6085 109709807
Feeling cold 35.58 10.06 418 872989 33569 109682323
Nasopharyngitis 35.51 10.06 2657 870750 391704 109324188
Breast cancer stage II 35.37 10.06 105 873302 27270 109688622
Muscular weakness 35.36 10.06 2346 871061 246122 109469770
Abdominal pain lower 35.33 10.06 450 872957 36833 109679059
Cardiac arrest 35.05 10.06 1236 872171 195517 109520375
Metastatic renal cell carcinoma 34.99 10.06 67 873340 2413 109713479
Heart rate increased 34.96 10.06 1429 871978 142405 109573487
Foot deformity 34.67 10.06 232 873175 48248 109667644
Trichorrhexis 34.62 10.06 40 873367 905 109714987
Cardiogenic shock 34.51 10.06 288 873119 57050 109658842
Chronic pigmented purpura 34.38 10.06 24 873383 270 109715622
Joint destruction 34.33 10.06 22 873385 10921 109704971
Hemiparesis 34.31 10.06 512 872895 43391 109672501
Suicide attempt 34.21 10.06 592 872815 102802 109613090
Diverticulum 34.20 10.06 225 873182 15301 109700591
Autoimmune hepatitis 34.12 10.06 217 873190 14587 109701305
Pulmonary embolism 33.81 10.06 2043 871364 212431 109503461
Exposure to toxic agent 33.77 10.06 31 873376 12827 109703065
Dry eye 33.76 10.06 624 872783 55169 109660723
Hip arthroplasty 33.75 10.06 280 873127 55533 109660359
Bacteraemia 33.33 10.06 197 873210 42193 109673699
Food allergy 33.26 10.06 67 873340 19881 109696011
Diffuse large B-cell lymphoma recurrent 33.26 10.06 5 873402 6294 109709598
Motor dysfunction 32.97 10.06 316 873091 24090 109691802
Hypersomnia 32.95 10.06 353 873054 27708 109688184
Dementia 32.91 10.06 389 873018 31284 109684608
Cardiac disorder 32.86 10.06 812 872595 75468 109640424
Normal newborn 32.83 10.06 78 873329 21818 109694074
Epiphysiolysis 32.69 10.06 19 873388 151 109715741
Cytomegalovirus chorioretinitis 32.69 10.06 8 873399 7120 109708772
Deep vein thrombosis postoperative 32.52 10.06 305 873102 58986 109656906
Product taste abnormal 32.45 10.06 66 873341 2486 109713406
Adrenal insufficiency 32.21 10.06 492 872915 41898 109673994
Hepatitis 31.97 10.06 509 872898 89545 109626347
Skin necrosis 31.97 10.06 77 873330 21435 109694457
Growth hormone deficiency 31.93 10.06 28 873379 449 109715443
Substance use disorder 31.87 10.06 9 873398 7281 109708611
Pneumonia fungal 31.67 10.06 42 873365 14712 109701180
Gingival pain 31.66 10.06 223 873184 15513 109700379
Acute myeloid leukaemia 31.64 10.06 174 873233 37936 109677956
Choking 31.50 10.06 216 873191 14894 109700998
Hiatus hernia 31.37 10.06 345 873062 27261 109688631
Pollakiuria 31.33 10.06 507 872900 43688 109672204
Juvenile idiopathic arthritis 31.19 10.06 5 873402 6002 109709890
Pneumonia 31.17 10.06 6280 867127 870434 108845458
Rhinorrhoea 30.99 10.06 1045 872362 101621 109614271
Body height decreased 30.96 10.06 165 873242 10398 109705494
Urine odour abnormal 30.65 10.06 128 873279 7287 109708605
Death 30.52 10.06 4951 868456 693918 109021974
Hypogammaglobulinaemia 30.52 10.06 71 873336 20005 109695887
Injection site mass 30.49 10.06 313 873094 24300 109691592
Pre-existing condition improved 30.46 10.06 117 873290 6409 109709483
Depressed mood 30.42 10.06 661 872746 60148 109655744
Nephritic syndrome 30.41 10.06 28 873379 480 109715412
Sedation 30.38 10.06 743 872664 68940 109646952
Lung cyst 30.27 10.06 28 873379 483 109715409
Alloimmunisation 30.26 10.06 10 873397 13 109715879
Blood test abnormal 30.25 10.06 352 873055 28202 109687690
Respiratory arrest 30.24 10.06 304 873103 57995 109657897
Hypertensive crisis 30.23 10.06 310 873097 24062 109691830
Local anaesthetic systemic toxicity 30.16 10.06 4 873403 5533 109710359
Thyroxine abnormal 30.09 10.06 9 873398 6 109715886
Inner ear disorder 30.03 10.06 34 873373 752 109715140
Vaginal discharge 29.99 10.06 60 873347 17848 109698044
Immunosuppressant drug level increased 29.93 10.06 29 873378 11695 109704197
Blood phosphorus increased 29.79 10.06 52 873355 16288 109699604
Vaginal haemorrhage 29.71 10.06 316 873091 24758 109691134
Delirium 29.69 10.06 825 872582 134200 109581692
Blood sodium decreased 29.60 10.06 446 872961 37873 109678019
Tropical infectious disease 29.60 10.06 12 873395 37 109715855
Appendicitis 29.48 10.06 120 873287 28344 109687548
Venoocclusive disease 29.37 10.06 7 873400 6343 109709549
Blood pressure systolic increased 29.33 10.06 861 872546 82130 109633762
Nerve compression 29.33 10.06 169 873238 10968 109704924
Oropharyngeal pain 29.08 10.06 1327 872080 133949 109581943
Femur fracture 28.91 10.06 503 872904 43966 109671926
Amnesia 28.86 10.06 1061 872346 104347 109611545
Gastrointestinal motility disorder 28.84 10.06 124 873283 7152 109708740
Speech disorder 28.83 10.06 663 872744 60906 109654986
Eye disorder 28.72 10.06 352 873055 28554 109687338
Autoimmune disorder 28.62 10.06 355 873052 65128 109650764
Poisoning deliberate 28.55 10.06 109 873298 26222 109689670
Product physical issue 28.37 10.06 96 873311 4940 109710952
Hepatic cirrhosis 28.29 10.06 370 873037 67256 109648636
Sleep apnoea syndrome 27.93 10.06 462 872945 39985 109675907
Deep vein thrombosis 27.89 10.06 1362 872045 138525 109577367
Red blood cell sedimentation rate 27.85 10.06 4 873403 5210 109710682
Product odour abnormal 27.74 10.06 47 873360 1536 109714356
Swelling face 27.69 10.06 939 872468 91382 109624510
Polyglandular autoimmune syndrome type II 27.60 10.06 11 873396 32 109715860
Hepatic enzyme 27.49 10.06 4 873403 5159 109710733
Ventricular fibrillation 27.43 10.06 202 873205 41111 109674781
Cardiac failure congestive 27.40 10.06 1457 871950 149543 109566349
Device difficult to use 27.40 10.06 68 873339 18737 109697155
Faeces discoloured 27.35 10.06 398 873009 33550 109682342
Swollen tongue 27.34 10.06 647 872760 59715 109656177
Influenza 27.25 10.06 1614 871793 167487 109548405
Somatic delusion 27.23 10.06 31 873376 690 109715202
Soft tissue disorder 27.18 10.06 75 873332 3449 109712443
Liver disorder 27.10 10.06 886 872521 141357 109574535
Breast discomfort 27.09 10.06 27 873380 513 109715379
Pelvic fracture 26.98 10.06 198 873209 13956 109701936
Therapeutic response decreased 26.87 10.06 569 872838 95930 109619962
Oral discomfort 26.82 10.06 167 873240 11144 109704748
Osteoarthritis 26.71 10.06 1174 872233 181449 109534443
Bronchitis 26.68 10.06 1506 871901 155526 109560366
Respiratory depression 26.63 10.06 146 873261 31855 109684037
Hyponatraemic seizure 26.60 10.06 31 873376 708 109715184
Nasal congestion 26.60 10.06 988 872419 97294 109618598
Acute graft versus host disease in intestine 26.51 10.06 6 873401 5633 109710259
Abdominal pain upper 26.43 10.06 3147 870260 345964 109369928
Cytopenia 26.40 10.06 135 873272 29981 109685911
Pulmonary pain 26.30 10.06 109 873298 6184 109709708
Hallucination 26.10 10.06 1014 872393 100418 109615474
Scar 26.08 10.06 225 873182 16656 109699236
Overlap syndrome 26.06 10.06 20 873387 9039 109706853
Upper limb fracture 26.05 10.06 266 873141 20622 109695270
Product administration error 26.03 10.06 426 872981 36791 109679101
Tongue discomfort 25.88 10.06 65 873342 2823 109713069
Immunodeficiency 25.74 10.06 190 873217 38648 109677244
Thyroxine decreased 25.73 10.06 34 873373 886 109715006
Enterococcal infection 25.68 10.06 79 873328 20287 109695605
Pancreatic neuroendocrine tumour 25.65 10.06 34 873373 889 109715003
Emotional distress 25.56 10.06 497 872910 44350 109671542
COVID-19 25.56 10.06 2258 871149 242802 109473090
Hemiplegia 25.56 10.06 284 873123 22498 109693394
Labyrinthitis 25.46 10.06 67 873340 2995 109712897
Sputum culture positive 25.41 10.06 78 873329 3811 109712081
Scleral discolouration 25.28 10.06 29 873378 651 109715241
Intervertebral disc protrusion 25.27 10.06 332 873075 27366 109688526
Pulmonary tuberculosis 25.25 10.06 21 873386 9118 109706774
Change of bowel habit 25.11 10.06 64 873343 2805 109713087
Systemic candida 25.08 10.06 25 873382 9949 109705943
Hormone level abnormal 25.03 10.06 57 873350 2323 109713569
Hypocalcaemia 25.01 10.06 685 872722 64681 109651211
Blood pressure inadequately controlled 25 10.06 123 873284 7510 109708382
Lung disorder 25.00 10.06 1164 872243 178883 109537009
International normalised ratio increased 24.88 10.06 878 872529 85894 109629998
Blood potassium decreased 24.81 10.06 581 872826 53533 109662359
Product dispensing error 24.80 10.06 217 873190 16128 109699764
Persistent depressive disorder 24.76 10.06 43 873364 1434 109714458
No adverse event 24.68 10.06 422 872985 73417 109642475
Pneumonia cytomegaloviral 24.67 10.06 12 873395 6942 109708950
Kounis syndrome 24.67 10.06 8 873399 5917 109709975
Cardiotoxicity 24.63 10.06 61 873346 16820 109699072
Gingival recession 24.62 10.06 44 873363 1502 109714390
Nasal obstruction 24.57 10.06 70 873337 3280 109712612
Oesophageal carcinoma 24.54 10.06 33 873374 11491 109704401
Tonsillar disorder 24.51 10.06 43 873364 1446 109714446
Tooth fracture 24.42 10.06 183 873224 12984 109702908
Panic attack 24.40 10.06 342 873065 28598 109687294
Posterior reversible encephalopathy syndrome 24.23 10.06 162 873245 33699 109682193
Renal disorder 24.17 10.06 536 872871 48943 109666949
Extremity contracture 24.14 10.06 47 873360 1714 109714178
Gingival disorder 24.13 10.06 80 873327 4073 109711819
Abnormal uterine bleeding 24.10 10.06 42 873365 1405 109714487
Psoriasis 24.06 10.06 1344 872063 138649 109577243
Grip strength 24.05 10.06 22 873385 9119 109706773
Aphonia 24.01 10.06 179 873228 12681 109703211
Sinus bradycardia 23.89 10.06 346 873061 29137 109686755
Increased tendency to bruise 23.87 10.06 167 873240 11591 109704301
Thyroiditis 23.77 10.06 109 873298 6464 109709428
Head discomfort 23.72 10.06 242 873165 18758 109697134
Loss of consciousness 23.70 10.06 1829 871578 194477 109521415
Diabetic ketoacidosis 23.60 10.06 465 872942 41593 109674299
Dystonia 23.58 10.06 114 873293 25691 109690201
Varicose vein 23.57 10.06 113 873294 6827 109709065
Immune effector cell-associated neurotoxicity syndrome 23.51 10.06 51 873356 14731 109701161
Exposure via ingestion 23.47 10.06 5 873402 4895 109710997
Retrograde amnesia 23.44 10.06 30 873377 757 109715135
Respiratory tract congestion 23.39 10.06 358 873049 30499 109685393
Presyncope 23.38 10.06 528 872879 48359 109667533
Drug tolerance 23.37 10.06 61 873346 16524 109699368
Lymphoproliferative disorder 23.35 10.06 14 873393 7204 109708688
Spinal osteoarthritis 23.28 10.06 253 873154 19930 109695962
Subcutaneous drug absorption impaired 23.21 10.06 16 873391 7643 109708249
Tri-iodothyronine increased 23.19 10.06 21 873386 352 109715540
Feeling jittery 23.15 10.06 197 873210 14525 109701367
Needle issue 23.13 10.06 229 873178 17611 109698281
Endocrine ophthalmopathy 23.06 10.06 40 873367 1333 109714559
Low turnover osteopathy 23.04 10.06 50 873357 1972 109713920
Cerebral salt-wasting syndrome 22.98 10.06 19 873388 280 109715612
Ear discomfort 22.98 10.06 160 873247 11089 109704803
Dysstasia 22.86 10.06 377 873030 32609 109683283
Colorectal cancer 22.74 10.06 23 873384 9091 109706801
Transcription medication error 22.72 10.06 27 873380 630 109715262
Atrioventricular block first degree 22.71 10.06 191 873216 14034 109701858
Rib deformity 22.70 10.06 17 873390 215 109715677
Somnolence 22.47 10.06 2681 870726 294768 109421124
Rotator cuff repair 22.44 10.06 53 873354 2213 109713679
Full blood count decreased 22.29 10.06 367 873040 31732 109684160
Hypothermia 22.24 10.06 311 873096 25991 109689901
Haematochezia 22.24 10.06 1121 872286 114403 109601489
Thyrotoxic periodic paralysis 22.20 10.06 16 873391 190 109715702
Infection reactivation 22.11 10.06 3 873404 4078 109711814
Acute kidney injury 22.07 10.06 5495 867912 629935 109085957
Sensory loss 22.06 10.06 263 873144 21194 109694698
Product blister packaging issue 21.96 10.06 20 873387 338 109715554
Respiratory disorder 21.94 10.06 414 872993 70968 109644924
Intervertebral disc degeneration 21.94 10.06 229 873178 17856 109698036
Primary hypothyroidism 21.79 10.06 18 873389 265 109715627
Unintentional medical device removal 21.72 10.06 23 873384 8900 109706992
Complication of device removal 21.70 10.06 83 873324 4537 109711355
Wrist fracture 21.67 10.06 191 873216 14226 109701666
Polyp 21.60 10.06 144 873263 9836 109706056
Product administered to patient of inappropriate age 21.55 10.06 19 873388 8017 109707875
Hyperglycaemia 21.51 10.06 849 872558 84241 109631651
Bacterial infection 21.48 10.06 246 873161 45790 109670102
Cerebral haematoma 21.47 10.06 140 873267 9492 109706400
Tooth abscess 21.43 10.06 235 873172 18554 109697338
Pulmonary arterial hypertension 21.39 10.06 369 873038 32199 109683693
Broncholithiasis 21.29 10.06 18 873389 274 109715618
Diabetes mellitus inadequate control 21.26 10.06 342 873065 29433 109686459
Breast cancer 21.25 10.06 425 872982 38117 109677775
Ascites 21.19 10.06 564 872843 92244 109623648
Urinary incontinence 21.16 10.06 518 872889 48069 109667823
Renal function test abnormal 21.16 10.06 132 873275 8814 109707078
Product colour issue 21.16 10.06 33 873374 1005 109714887
Thyroid cancer recurrent 21.13 10.06 10 873397 49 109715843
Polyhydramnios 21.12 10.06 47 873360 1886 109714006
Lip blister 21.09 10.06 66 873341 3259 109712633
Kidney transplant rejection 21.09 10.06 39 873368 11948 109703944
Cytomegalovirus colitis 21.07 10.06 15 873392 7046 109708846
Product solubility abnormal 21.03 10.06 35 873372 1127 109714765
Paradoxical drug reaction 21.02 10.06 28 873379 9789 109706103
Stenotrophomonas infection 20.95 10.06 10 873397 5848 109710044
Ingrowing nail 20.92 10.06 65 873342 3197 109712695
Lipodystrophy acquired 20.90 10.06 5 873402 4519 109711373
Cholelithiasis 20.81 10.06 652 872755 62770 109653122
Bladder disorder 20.78 10.06 155 873252 10982 109704910
Dysarthria 20.72 10.06 837 872570 83284 109632608
Status epilepticus 20.66 10.06 155 873252 31416 109684476
Stress fracture 20.62 10.06 112 873295 7109 109708783
Alanine aminotransferase abnormal 20.62 10.06 26 873381 9308 109706584
Nasal polyps 20.62 10.06 46 873361 13154 109702738
Meningitis cryptococcal 20.60 10.06 6 873401 4756 109711136
Reaction to preservatives 20.54 10.06 17 873390 251 109715641
Product tampering 20.52 10.06 22 873385 457 109715435
Acute lymphocytic leukaemia recurrent 20.51 10.06 10 873397 5777 109710115
Hypokalaemia 20.42 10.06 1690 871717 180758 109535134
Pituitary tumour 20.39 10.06 36 873371 1217 109714675
Radiculopathy 20.35 10.06 81 873326 19255 109696637
Oculogyric crisis 20.33 10.06 3 873404 3829 109712063
Anti-thyroid antibody positive 20.30 10.06 24 873383 557 109715335
Upper-airway cough syndrome 20.29 10.06 203 873204 15654 109700238
Blood calcium increased 20.29 10.06 225 873182 17815 109698077
Exophthalmos 20.20 10.06 51 873356 2222 109713670
Anti-cyclic citrullinated peptide antibody 20.16 10.06 85 873322 19879 109696013
Acute respiratory distress syndrome 20.13 10.06 297 873110 52901 109662991
Myelodysplastic syndrome 20.05 10.06 194 873213 37290 109678602
Laryngitis 20.04 10.06 226 873181 42185 109673707
Viraemia 20.03 10.06 4 873403 4098 109711794
Epstein-Barr virus infection reactivation 19.91 10.06 4 873403 4080 109711812
Pain threshold decreased 19.89 10.06 8 873399 24 109715868
Respiratory tract malformation 19.88 10.06 12 873395 103 109715789
Type 1 diabetes mellitus 19.86 10.06 131 873276 8916 109706976
Lymphadenectomy 19.86 10.06 40 873367 1496 109714396
Pregnancy 19.71 10.06 284 873123 50783 109665109
Labile hypertension 19.71 10.06 24 873383 575 109715317
Piloerection 19.66 10.06 29 873378 840 109715052
Dilatation atrial 19.60 10.06 71 873336 3781 109712111
Cardiac failure 19.59 10.06 1729 871678 185897 109529995
Application site erythema 19.53 10.06 92 873315 5518 109710374
Pleural neoplasm 19.49 10.06 20 873387 394 109715498
Post procedural hypothyroidism 19.47 10.06 17 873390 271 109715621
Restlessness 19.43 10.06 582 872825 55677 109660215
Forced vital capacity decreased 19.42 10.06 46 873361 1924 109713968
Peripheral coldness 19.40 10.06 228 873179 18312 109697580
Intentional underdose 19.37 10.06 54 873353 2498 109713394
Spondylolisthesis 19.32 10.06 70 873337 3728 109712164
Cross sensitivity reaction 19.16 10.06 10 873397 5557 109710335
Drug specific antibody present 19.15 10.06 23 873384 8411 109707481
Gastric disorder 19.13 10.06 370 873037 32987 109682905
Ventricular tachycardia 19.11 10.06 524 872883 49485 109666407
Chromaturia 19.05 10.06 332 873075 29028 109686864
Altered state of consciousness 19.04 10.06 330 873077 57296 109658596
Thrombosis 19.02 10.06 1045 872362 107617 109608275
Product measured potency issue 19.01 10.06 15 873392 206 109715686
Growth hormone-producing pituitary tumour 18.94 10.06 13 873394 142 109715750
Bladder cancer 18.92 10.06 89 873318 20203 109695689
Tooth disorder 18.90 10.06 333 873074 29176 109686716
Throat clearing 18.86 10.06 76 873331 4257 109711635
Coma 18.86 10.06 750 872657 117119 109598773
Hepatitis acute 18.85 10.06 229 873178 18537 109697355
Listless 18.71 10.06 78 873329 4437 109711455
Hyperthermia malignant 18.64 10.06 4 873403 3896 109711996
Road traffic accident 18.59 10.06 677 872730 106721 109609171
Blood loss anaemia 18.56 10.06 221 873186 17804 109698088
Rheumatoid arthritis 18.50 10.06 2077 871330 297536 109418356
Papillitis 18.42 10.06 13 873394 149 109715743
Viral mutation identified 18.34 10.06 6 873401 4413 109711479
Lacrimation increased 18.33 10.06 345 873062 30605 109685287
Poor quality product administered 18.32 10.06 79 873328 4562 109711330
Medullary thyroid cancer 18.23 10.06 18 873389 338 109715554
Amniotic fluid volume increased 18.21 10.06 13 873394 152 109715740
Incorrect dose administered 18.20 10.06 997 872410 102644 109613248
Musculoskeletal discomfort 18.20 10.06 274 873133 23264 109692628
Labelled drug-drug interaction medication error 18.18 10.06 329 873078 28973 109686919
Total lung capacity abnormal 18.08 10.06 78 873329 4505 109711387
Dental caries 18.06 10.06 167 873240 12606 109703286
Hypoaesthesia 18.03 10.06 2189 871218 312034 109403858
Orthostatic intolerance 17.96 10.06 47 873360 2094 109713798
Poor sucking reflex 17.96 10.06 12 873395 125 109715767
Dysuria 17.90 10.06 612 872795 59619 109656273
Serotonin syndrome 17.90 10.06 344 873063 58809 109657083
Bone loss 17.89 10.06 59 873348 2996 109712896
Ejection fraction abnormal 17.79 10.06 64 873343 3396 109712496
Supraventricular extrasystoles 17.79 10.06 117 873290 7956 109707936
Musculoskeletal pain 17.77 10.06 1225 872182 181798 109534094
Electrocardiogram ST segment elevation 17.77 10.06 28 873379 9132 109706760
Fractured coccyx 17.77 10.06 34 873373 1224 109714668
Device material issue 17.71 10.06 21 873386 489 109715403
Shunt malfunction 17.65 10.06 18 873389 352 109715540
Cholecystitis chronic 17.60 10.06 132 873275 9368 109706524
Rheumatoid lung 17.59 10.06 6 873401 4298 109711594
Hyperchromic anaemia 17.58 10.06 14 873393 195 109715697
Parosmia 17.48 10.06 170 873237 13010 109702882
Chest injury 17.48 10.06 63 873344 3346 109712546
Anaemia 17.47 10.06 4714 868693 542372 109173520
Adenoiditis 17.44 10.06 8 873399 36 109715856
Lymph node calcification 17.43 10.06 20 873387 449 109715443
Amyloid arthropathy 17.41 10.06 40 873367 1640 109714252
Lethargy 17.39 10.06 905 872502 92671 109623221
Body temperature decreased 17.37 10.06 398 873009 36537 109679355
Lymphocyte count decreased 17.29 10.06 333 873074 56910 109658982
Rhinitis allergic 17.27 10.06 217 873190 17705 109698187
Hypophagia 17.26 10.06 541 872866 52085 109663807
Immune-mediated hypothyroidism 17.26 10.06 56 873351 2819 109713073
Sprue-like enteropathy 17.16 10.06 40 873367 1656 109714236
Staphylococcal infection 17.05 10.06 421 872986 69523 109646369
Joint dislocation 17.03 10.06 180 873227 34010 109681882
Visual field defect 17.03 10.06 137 873270 9935 109705957
Depressed level of consciousness 17.03 10.06 1066 872341 111212 109604680
Hyperphosphataemia 17.00 10.06 69 873338 16312 109699580
Insomnia 16.99 10.06 3164 870243 357426 109358466
Embedded device 16.97 10.06 70 873337 3963 109711929
Panic disorder 16.94 10.06 63 873344 3398 109712494
Breast cancer stage I 16.93 10.06 20 873387 7367 109708525
Thyroglobulin decreased 16.92 10.06 5 873402 3 109715889
Neovascular age-related macular degeneration 16.89 10.06 22 873385 565 109715327
Potassium wasting nephropathy 16.88 10.06 13 873394 172 109715720
Transplant failure 16.78 10.06 12 873395 5623 109710269
Underdose 16.75 10.06 378 873029 63176 109652716
Erythema dyschromicum perstans 16.75 10.06 10 873397 84 109715808
Fracture 16.70 10.06 282 873125 24506 109691386
Pulse abnormal 16.67 10.06 71 873336 4078 109711814
Lactose intolerance 16.60 10.06 54 873353 2722 109713170
Restless legs syndrome 16.53 10.06 280 873127 24346 109691546
Bundle branch block left 16.50 10.06 165 873242 12723 109703169
Meniere's disease 16.48 10.06 12 873395 145 109715747
Acinetobacter infection 16.40 10.06 4 873403 3569 109712323
Hepatitis B reactivation 16.38 10.06 21 873386 7463 109708429
Nephrectomy 16.37 10.06 52 873355 2588 109713304
COVID-19 pneumonia 16.36 10.06 201 873206 36942 109678950
Decreased bronchial secretion 16.31 10.06 9 873398 64 109715828
Spondylolysis 16.25 10.06 14 873393 219 109715673
Nasal oedema 16.23 10.06 18 873389 6821 109709071
Procedural pain 16.23 10.06 191 873216 35374 109680518
Limb discomfort 16.16 10.06 430 872977 40424 109675468
Illness 16.16 10.06 799 872608 81372 109634520
Hair texture abnormal 16.15 10.06 68 873339 3886 109712006
Hypoglycaemic unconsciousness 16.05 10.06 32 873375 1188 109714704
Haemoglobinaemia 16.01 10.06 17 873390 349 109715543
Blood alkaline phosphatase increased 15.93 10.06 699 872708 70236 109645656
Arteriosclerosis coronary artery 15.93 10.06 283 873124 24835 109691057
Neuroleptic malignant syndrome 15.89 10.06 182 873225 33877 109682015
Medulloblastoma recurrent 15.87 10.06 13 873394 189 109715703
Pulmonary valve incompetence 15.84 10.06 52 873355 2634 109713258
Miosis 15.82 10.06 105 873302 21878 109694014
Initial insomnia 15.80 10.06 138 873269 10251 109705641
Distributive shock 15.79 10.06 14 873393 5890 109710002
Injection site discomfort 15.77 10.06 101 873306 6806 109709086
Painful respiration 15.74 10.06 65 873342 3682 109712210
Peripheral swelling 15.73 10.06 2880 870527 401154 109314738
Heart rate decreased 15.72 10.06 802 872605 81954 109633938
Claustrophobia 15.71 10.06 37 873370 1542 109714350
Diverticulitis 15.70 10.06 543 872864 52979 109662913
Pituitary cyst 15.70 10.06 6 873401 15 109715877
Delayed graft function 15.64 10.06 7 873400 4250 109711642
Crying 15.63 10.06 287 873120 25341 109690551
Secondary hypogonadism 15.63 10.06 26 873381 837 109715055
Barrett's oesophagus 15.62 10.06 23 873384 665 109715227
Meningioma 15.60 10.06 87 873320 5578 109710314
Vaccination site reaction 15.54 10.06 14 873393 233 109715659
Anal prolapse 15.54 10.06 9 873398 71 109715821
Hypoalbuminaemia 15.48 10.06 150 873257 28824 109687068
Ecchymosis 15.48 10.06 207 873200 17131 109698761
Virologic failure 15.47 10.06 10 873397 4942 109710950
Internal haemorrhage 15.44 10.06 134 873273 9937 109705955
Tenosynovitis 15.43 10.06 71 873336 16212 109699680
Drug eruption 15.35 10.06 315 873092 53344 109662548
Tracheal pain 15.34 10.06 8 873399 50 109715842
Pneumonia bacterial 15.31 10.06 133 873274 26128 109689764
Gastrointestinal pain 15.26 10.06 152 873255 11708 109704184
Joint stiffness 15.26 10.06 409 872998 66834 109649058
Thyroid dermatopathy 15.17 10.06 7 873400 32 109715860
Basedow's disease 15.16 10.06 13 873394 202 109715690
Methaemoglobinaemia 15.11 10.06 31 873376 9137 109706755
Essential hypertension 15.09 10.06 110 873297 7737 109708155
Impaired driving ability 15.07 10.06 94 873313 6276 109709616
Electrocardiogram QT prolonged 14.99 10.06 1026 872381 107934 109607958
Cardiac pacemaker insertion 14.92 10.06 93 873314 6208 109709684
Muscle fatigue 14.90 10.06 67 873340 3940 109711952
Mobility decreased 14.90 10.06 1644 871763 235778 109480114
Staphylococcal sepsis 14.87 10.06 79 873328 17375 109698517
Neuromyopathy 14.87 10.06 39 873368 1740 109714152
Hair colour changes 14.86 10.06 75 873332 4626 109711266
Thyroid cancer metastatic 14.85 10.06 12 873395 171 109715721
Menopause 14.84 10.06 49 873358 2489 109713403
Nocturia 14.82 10.06 202 873205 16788 109699104
Catarrh 14.79 10.06 104 873303 7231 109708661
Pneumatosis intestinalis 14.78 10.06 28 873379 8501 109707391
Wrong patient 14.78 10.06 35 873372 1464 109714428
Inappropriate antidiuretic hormone secretion 14.77 10.06 361 873046 33490 109682402
Rib fracture 14.70 10.06 360 873047 33410 109682482
Hospice care 14.69 10.06 157 873250 12316 109703576
Rhinovirus infection 14.67 10.06 46 873361 11743 109704149
Vertigo positional 14.67 10.06 66 873341 3882 109712010
Gastric polyps 14.67 10.06 84 873323 5439 109710453
Mean cell haemoglobin concentration increased 14.66 10.06 29 873378 1070 109714822
Device use issue 14.62 10.06 64 873343 3720 109712172
Blood cholesterol decreased 14.62 10.06 51 873356 2665 109713227
Colitis microscopic 14.59 10.06 166 873241 13228 109702664
Rhabdomyolysis 14.56 10.06 1122 872285 119279 109596613
Creatinine renal clearance increased 14.54 10.06 62 873345 3563 109712329
Thyrotoxic cardiomyopathy 14.53 10.06 5 873402 8 109715884
Groin pain 14.52 10.06 186 873221 15242 109700650
Maternal exposure during delivery 14.51 10.06 5 873402 3560 109712332
Empty sella syndrome 14.44 10.06 11 873396 143 109715749
Pituitary apoplexy 14.44 10.06 15 873392 300 109715592
Lower limb fracture 14.42 10.06 469 872938 74879 109641013
Thyroid mass 14.40 10.06 79 873328 5034 109710858
Ear canal erythema 14.37 10.06 8 873399 58 109715834
Recalled product 14.36 10.06 28 873379 1022 109714870
Product packaging issue 14.34 10.06 37 873370 1634 109714258
Sleep disorder therapy 14.34 10.06 23 873384 7448 109708444
Frontotemporal dementia 14.32 10.06 22 873385 661 109715231
Ventricular hypertrophy 14.27 10.06 100 873307 6945 109708947
Device breakage 14.26 10.06 169 873238 13600 109702292
Aortic valve incompetence 14.26 10.06 141 873266 10840 109705052
Onychoclasis 14.23 10.06 102 873305 7135 109708757
Allergy to chemicals 14.22 10.06 58 873349 3267 109712625
Cortisol decreased 14.20 10.06 52 873355 2784 109713108
Post procedural hypoparathyroidism 14.17 10.06 5 873402 9 109715883
Electrocardiogram abnormal 14.16 10.06 217 873190 18492 109697400
N-terminal prohormone brain natriuretic peptide abnormal 14.13 10.06 15 873392 308 109715584
Urine sodium decreased 14.09 10.06 14 873393 265 109715627
Abnormal weight gain 14.08 10.06 61 873346 3530 109712362
Vulvovaginitis 14.02 10.06 16 873391 357 109715535
Eczema 14.02 10.06 702 872705 71591 109644301
Sjogren's syndrome 14.01 10.06 23 873384 732 109715160
Pituitary haemorrhage 14.01 10.06 15 873392 311 109715581
Blood pressure abnormal 13.99 10.06 252 873155 22172 109693720
Polymyalgia rheumatica 13.97 10.06 93 873314 6349 109709543
Acute myeloid leukaemia recurrent 13.97 10.06 12 873395 5127 109710765
Poor quality device used 13.92 10.06 52 873355 2811 109713081
Muscle tightness 13.91 10.06 178 873229 14584 109701308
Skin laceration 13.85 10.06 357 873050 33396 109682496
Magnetic resonance imaging thoracic abnormal 13.83 10.06 5 873402 10 109715882
Gastric pH increased 13.82 10.06 8 873399 63 109715829
Brain oedema 13.81 10.06 168 873239 30930 109684962
Intermenstrual bleeding 13.80 10.06 98 873309 6836 109709056
Mandibular mass 13.79 10.06 13 873394 230 109715662
Follicular thyroid cancer 13.77 10.06 9 873398 90 109715802
Sensation of foreign body 13.77 10.06 109 873298 7866 109708026
Hepatic steatosis 13.73 10.06 493 872914 48338 109667554
Blood glucose fluctuation 13.72 10.06 106 873301 7592 109708300
Chronic fatigue syndrome 13.69 10.06 33 873374 1396 109714496
Lupus nephritis 13.69 10.06 10 873397 4635 109711257
Wrong patient received product 13.67 10.06 95 873312 6579 109709313
Ankylosing spondylitis 13.67 10.06 70 873337 15542 109700350
Gene mutation 13.64 10.06 5 873402 3424 109712468
Oral candidiasis 13.63 10.06 260 873147 44500 109671392
Musculoskeletal chest pain 13.62 10.06 311 873096 28536 109687356
JC virus infection 13.60 10.06 13 873394 5277 109710615
Application site pruritus 13.60 10.06 67 873340 4093 109711799
Mitral valve incompetence 13.53 10.06 352 873055 32977 109682915
Disability 13.52 10.06 163 873244 30060 109685832
Disturbance in social behaviour 13.52 10.06 12 873395 5046 109710846
Cerebral toxoplasmosis 13.51 10.06 4 873403 3138 109712754
Blood uric acid increased 13.48 10.06 107 873300 21422 109694470
Pulmonary mass 13.46 10.06 388 873019 36913 109678979
Vessel puncture site haemorrhage 13.46 10.06 12 873395 197 109715695
Senile osteoporosis 13.45 10.06 10 873397 125 109715767
Muscle contractions involuntary 13.42 10.06 70 873337 4374 109711518
Lactation disorder 13.40 10.06 14 873393 282 109715610
Uterine cyst 13.35 10.06 15 873392 329 109715563
Neck injury 13.34 10.06 55 873352 3113 109712779
Antinuclear antibody increased 13.31 10.06 29 873378 1147 109714745
Priapism 13.29 10.06 16 873391 5845 109710047
Complications of transplanted kidney 13.28 10.06 24 873383 7418 109708474
Bradykinesia 13.27 10.06 137 873270 10651 109705241
Product residue present 13.26 10.06 64 873343 3877 109712015
Germ cell cancer 13.26 10.06 12 873395 201 109715691
Skin discolouration 13.26 10.06 493 872914 48553 109667339
Neuritis 13.26 10.06 102 873305 7297 109708595
Cerebral haemorrhage 13.25 10.06 634 872773 64334 109651558
Obstructive airways disorder 13.24 10.06 467 872940 45682 109670210
Conjunctivitis allergic 13.24 10.06 97 873310 6834 109709058
Ischaemic hepatitis 13.21 10.06 72 873335 4576 109711316
Liver function test normal 13.18 10.06 4 873403 3 109715889
Extrapyramidal disorder 13.18 10.06 155 873252 28712 109687180
Impaired work ability 13.16 10.06 287 873120 26132 109689760
Uterine leiomyoma 13.13 10.06 106 873301 7694 109708198
Rectal polyp 13.12 10.06 34 873373 1506 109714386
Ventilation perfusion mismatch 13.10 10.06 23 873384 774 109715118
Paraesthesia oral 13.09 10.06 187 873220 33484 109682408
Lymphatic system neoplasm 13.03 10.06 8 873399 71 109715821
Dry mouth 13.01 10.06 1381 872026 198567 109517325
Neuroglycopenia 13.01 10.06 28 873379 1098 109714794
Glomerular filtration rate decreased 13.00 10.06 310 873097 28646 109687246
Progressive multifocal leukoencephalopathy 13.00 10.06 130 873277 24826 109691066
Anaemia postoperative 12.99 10.06 39 873368 1882 109714010
Knee arthroplasty 12.98 10.06 402 873005 64546 109651346
Arthritis 12.98 10.06 1513 871894 166073 109549819
Mouth breathing 12.97 10.06 14 873393 293 109715599
Laryngeal injury 12.94 10.06 5 873402 13 109715879
Macular degeneration 12.94 10.06 109 873298 21550 109694342
Hyperammonaemia 12.94 10.06 60 873347 13672 109702220
Ventricular extrasystoles 12.93 10.06 251 873156 22390 109693502
Cerebral microangiopathy 12.93 10.06 16 873391 390 109715502
Bezoar 12.92 10.06 8 873399 4046 109711846
Tongue haematoma 12.92 10.06 13 873394 250 109715642
Rhinitis 12.90 10.06 250 873157 22295 109693597
Tri-iodothyronine free decreased 12.90 10.06 17 873390 442 109715450
Thyroid neoplasm 12.89 10.06 56 873351 3245 109712647
General symptom 12.88 10.06 32 873375 8814 109707078
Sopor 12.87 10.06 379 873028 36167 109679725
Stress urinary incontinence 12.85 10.06 39 873368 1894 109713998
Intervertebral disc disorder 12.83 10.06 81 873326 5431 109710461
Familial periodic paralysis 12.82 10.06 15 873392 344 109715548
Acquired gene mutation 12.81 10.06 3 873404 2751 109713141
Radius fracture 12.78 10.06 64 873343 3936 109711956
Tooth dislocation 12.77 10.06 7 873400 49 109715843
Blood calcitonin increased 12.77 10.06 7 873400 49 109715843
Bacterial sepsis 12.75 10.06 41 873366 10385 109705507
Migraine with aura 12.70 10.06 58 873349 3434 109712458
Oesophageal disorder 12.69 10.06 53 873354 3017 109712875
Colitis ulcerative 12.65 10.06 491 872916 76872 109639020
Hypophosphataemia 12.64 10.06 185 873222 32997 109682895
Anaphylactic shock 12.63 10.06 310 873097 51236 109664656
Haemangioma of liver 12.62 10.06 32 873375 1398 109714494
Circulating anticoagulant positive 12.58 10.06 6 873401 30 109715862
Throat tightness 12.54 10.06 350 873057 33139 109682753
Apathy 12.54 10.06 189 873218 16050 109699842
Antinuclear antibody positive 12.53 10.06 119 873288 9049 109706843
Sensory level abnormal 12.51 10.06 11 873396 177 109715715
Oesophageal achalasia 12.50 10.06 26 873381 995 109714897
Capillaritis 12.45 10.06 45 873362 2394 109713498
Burns second degree 12.44 10.06 104 873303 7629 109708263
Neutrophil function disorder 12.42 10.06 6 873401 31 109715861
Vulvovaginal discomfort 12.42 10.06 41 873366 2083 109713809
Traumatic ulcer 12.41 10.06 9 873398 108 109715784
Expired product administered 12.39 10.06 110 873297 8210 109707682
Peripheral circulatory failure 12.37 10.06 37 873370 1782 109714110
Exostosis of jaw 12.35 10.06 29 873378 1206 109714686
Coronary artery occlusion 12.35 10.06 184 873223 15588 109700304
Epistaxis 12.34 10.06 1193 872214 129179 109586713
Deep brain stimulation 12.33 10.06 8 873399 79 109715813
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 12.33 10.06 8 873399 79 109715813
Hypotensive transfusion reaction 12.33 10.06 8 873399 79 109715813
Breast mass 12.31 10.06 108 873299 8033 109707859
Gastric cancer 12.31 10.06 45 873362 10963 109704929
Feeling drunk 12.29 10.06 80 873327 5420 109710472
Pernicious anaemia 12.29 10.06 22 873385 752 109715140
Brain neoplasm 12.28 10.06 89 873318 6248 109709644
Nasal discharge discolouration 12.26 10.06 54 873353 3147 109712745
Product use complaint 12.26 10.06 61 873346 3742 109712150
Autoimmune dermatitis 12.25 10.06 12 873395 223 109715669
Unmasking of previously unidentified disease 12.24 10.06 50 873357 2818 109713074
Skin irritation 12.24 10.06 189 873218 16130 109699762
Subcutaneous haematoma 12.23 10.06 52 873355 2984 109712908
Cataract operation 12.21 10.06 84 873323 5799 109710093
Hypoglycaemic seizure 12.19 10.06 25 873382 947 109714945
Toxic anterior segment syndrome 12.19 10.06 6 873401 3448 109712444
Immediate post-injection reaction 12.17 10.06 16 873391 415 109715477
Brain natriuretic peptide abnormal 12.16 10.06 24 873383 884 109715008
Gallbladder neoplasm 12.16 10.06 8 873399 81 109715811
Periorbital inflammation 12.12 10.06 13 873394 270 109715622
Parkinson's disease 12.12 10.06 33 873374 1506 109714386
Superficial vein prominence 12.08 10.06 8 873399 82 109715810
Rhythm idioventricular 12.06 10.06 22 873385 763 109715129
Vomiting 12.06 10.06 7611 865796 903064 108812828
Dactylitis 12.05 10.06 9 873398 4124 109711768
Pneumonia viral 12.03 10.06 138 873269 11019 109704873
Histoplasmosis disseminated 12.01 10.06 8 873399 3891 109712001
Bruxism 12.01 10.06 74 873333 4920 109710972
Herpes simplex 12.00 10.06 74 873333 15690 109700202
Oropharyngeal swelling 12.00 10.06 32 873375 1442 109714450
Drug level increased 11.97 10.06 286 873121 47433 109668459
Spinal fracture 11.96 10.06 248 873159 22385 109693507
Bundle branch block right 11.92 10.06 149 873258 12142 109703750
Skin dystrophy 11.90 10.06 7 873400 57 109715835
Strabismus 11.90 10.06 57 873350 3442 109712450
Angle closure glaucoma 11.90 10.06 57 873350 3442 109712450
Acute lung injury 11.86 10.06 5 873402 3146 109712746
Product packaging confusion 11.86 10.06 15 873392 374 109715518
Rheumatic disorder 11.86 10.06 58 873349 3533 109712359
Nightmare 11.83 10.06 396 873011 38467 109677425
Blood urea nitrogen/creatinine ratio increased 11.83 10.06 31 873376 1382 109714510
Retching 11.81 10.06 248 873159 22434 109693458
Tonsillar cyst 11.78 10.06 4 873403 6 109715886
Loss of employment 11.76 10.06 55 873352 3289 109712603
Disinhibition 11.76 10.06 5 873402 3129 109712763
Vitamin D deficiency 11.75 10.06 209 873198 18343 109697549
Body height increased 11.73 10.06 10 873397 154 109715738
Mydriasis 11.72 10.06 115 873292 22042 109693850
Prescribed underdose 11.70 10.06 409 872998 64765 109651127
Analgesic therapy 11.69 10.06 25 873382 7259 109708633
Dermatomyositis 11.69 10.06 67 873340 4339 109711553
Propofol infusion syndrome 11.69 10.06 3 873404 2586 109713306
Product coating issue 11.69 10.06 9 873398 119 109715773
Malignant melanoma 11.68 10.06 193 873214 16698 109699194
Emotional disorder 11.68 10.06 186 873221 15974 109699918
Retinal artery embolism 11.63 10.06 10 873397 156 109715736
Pigmentation disorder 11.58 10.06 98 873309 7213 109708679
Glycosylated haemoglobin increased 11.58 10.06 256 873151 23363 109692529
Nasal dryness 11.56 10.06 81 873326 5625 109710267
Clear cell endometrial carcinoma 11.55 10.06 3 873404 0 109715892
Stasis syndrome 11.55 10.06 3 873404 0 109715892
Hydrocele operation 11.55 10.06 3 873404 0 109715892
Gallbladder mucocoele 11.55 10.06 3 873404 0 109715892
Cronkhite-Canada syndrome 11.55 10.06 3 873404 0 109715892
Synovial cyst removal 11.55 10.06 3 873404 0 109715892
Acrophobia 11.55 10.06 3 873404 0 109715892
Primary hyperthyroidism 11.55 10.06 3 873404 0 109715892
Blood proinsulin increased 11.55 10.06 3 873404 0 109715892
Thyroid pain 11.55 10.06 3 873404 0 109715892
Mite allergy 11.54 10.06 82 873325 5721 109710171
Pulmonary vasculitis 11.51 10.06 90 873317 6470 109709422
Bacteriuria 11.49 10.06 31 873376 1407 109714485
Madarosis 11.48 10.06 56 873351 3407 109712485
Kidney infection 11.47 10.06 274 873133 25325 109690567
Carcinoembryonic antigen 11.46 10.06 8 873399 90 109715802
Leukopenia 11.46 10.06 1015 872392 147776 109568116
Electrolyte imbalance 11.45 10.06 378 873029 36650 109679242
Urine output increased 11.44 10.06 48 873359 2738 109713154
Secondary immunodeficiency 11.44 10.06 12 873395 4664 109711228
Adenoid cystic carcinoma 11.44 10.06 6 873401 38 109715854
Ankle arthroplasty 11.43 10.06 3 873404 2548 109713344
Cytomegalovirus test positive 11.42 10.06 24 873383 7012 109708880
Temperature intolerance 11.42 10.06 164 873243 13786 109702106
Expired device used 11.41 10.06 20 873387 672 109715220
Presbyacusis 11.40 10.06 4 873403 2815 109713077
Sleep disorder due to a general medical condition 11.37 10.06 512 872895 51600 109664292
Cerebellar haematoma 11.35 10.06 19 873388 615 109715277
Hyperbilirubinaemia 11.34 10.06 172 873235 30499 109685393
Cholecystectomy 11.34 10.06 133 873274 10676 109705216
Stress 11.33 10.06 973 872434 104375 109611517
Dermatitis atopic 11.33 10.06 273 873134 25268 109690624
Gastric hypomotility 11.32 10.06 13 873394 292 109715600
Therapeutic product effect variable 11.30 10.06 47 873360 2671 109713221
Tuberculosis 11.28 10.06 88 873319 17686 109698206
Coronavirus test positive 11.28 10.06 29 873378 1278 109714614
Pancreatolithiasis 11.26 10.06 14 873393 343 109715549
Metastases to lung 11.25 10.06 122 873285 22941 109692951
Breath odour 11.24 10.06 38 873369 1954 109713938
Haemoglobin decreased 11.24 10.06 2178 871229 246549 109469343
Astrocytoma 11.24 10.06 12 873395 248 109715644
Metastases to bone 11.24 10.06 177 873230 31195 109684697
Thinking abnormal 11.23 10.06 175 873232 14965 109700927
Breast disorder 11.22 10.06 42 873365 2272 109713620
Blood prolactin decreased 11.22 10.06 13 873394 295 109715597
Chondromalacia 11.22 10.06 10 873397 164 109715728
Pneumonia pseudomonal 11.22 10.06 27 873380 7519 109708373
Congenital central nervous system anomaly 11.21 10.06 9 873398 127 109715765
Ophthalmic vein thrombosis 11.20 10.06 12 873395 249 109715643
Hyperkalaemia 11.19 10.06 1231 872176 134565 109581327
Bronchial secretion retention 11.18 10.06 73 873334 4951 109710941
Orbital swelling 11.17 10.06 8 873399 94 109715798
Parainfluenzae virus infection 11.14 10.06 24 873383 6950 109708942
Fanconi syndrome acquired 11.13 10.06 5 873402 3029 109712863
Postmenopausal haemorrhage 11.12 10.06 36 873371 1810 109714082
Dyspepsia 11.11 10.06 1329 872078 189636 109526256
Milk-alkali syndrome 11.10 10.06 38 873369 1967 109713925
Pneumocystis jirovecii infection 11.10 10.06 11 873396 4389 109711503
Ovarian cyst 11.10 10.06 163 873244 13767 109702125
Therapeutic response changed 11.09 10.06 33 873374 1585 109714307
Prophylaxis 11.07 10.06 4 873403 8 109715884
Pseudomembranous colitis 11.06 10.06 21 873386 6370 109709522
Bedridden 11.06 10.06 158 873249 13267 109702625
Generalised tonic-clonic seizure 11.03 10.06 338 873069 54342 109661550
Mineral deficiency 11.03 10.06 8 873399 96 109715796
Thyroglobulin increased 11.03 10.06 8 873399 96 109715796
Myopathy toxic 11.03 10.06 29 873378 1296 109714596
Invasive ductal breast carcinoma 11.02 10.06 90 873317 6556 109709336
Drug abuser 11.01 10.06 16 873391 5393 109710499
Spondylitis 11.00 10.06 49 873358 11289 109704603
Breath sounds abnormal 10.99 10.06 138 873269 25266 109690626
Aggression 10.99 10.06 370 873037 58840 109657052
Skin tightness 10.98 10.06 79 873328 5534 109710358
Metastases to liver 10.95 10.06 205 873202 35181 109680711
Lens disorder 10.93 10.06 10 873397 170 109715722
Retroplacental haematoma 10.92 10.06 9 873398 132 109715760
Radiation inflammation 10.91 10.06 25 873382 1023 109714869
Electrocardiogram QRS complex abnormal 10.88 10.06 21 873386 761 109715131
Calcinosis 10.84 10.06 48 873359 2804 109713088
Febrile bone marrow aplasia 10.84 10.06 87 873320 17378 109698514
Tension 10.83 10.06 73 873334 5005 109710887
Endocrine disorder 10.82 10.06 26 873381 1098 109714794
Application site vesicles 10.81 10.06 32 873375 1532 109714360
Congenital muscle absence 10.81 10.06 5 873402 23 109715869
Sinusitis 10.81 10.06 2122 871285 294566 109421326
Bone formation increased 10.80 10.06 7 873400 69 109715823
Drug level decreased 10.79 10.06 94 873313 18454 109697438
Toothache 10.77 10.06 253 873154 23322 109692570
Iron deficiency anaemia 10.77 10.06 326 873081 31233 109684659
Osteitis deformans 10.75 10.06 11 873396 216 109715676
Decreased interest 10.73 10.06 71 873336 4837 109711055
Therapeutic product effect increased 10.72 10.06 34 873373 1691 109714201
Sinus node dysfunction 10.71 10.06 114 873293 8933 109706959
Eye ulcer 10.71 10.06 14 873393 361 109715531
Vulvovaginal mycotic infection 10.70 10.06 76 873331 5301 109710591
Blood immunoglobulin G abnormal 10.70 10.06 9 873398 136 109715756
Urine chloride decreased 10.70 10.06 8 873399 101 109715791
Disseminated tuberculosis 10.69 10.06 15 873392 5131 109710761
Nail toxicity 10.68 10.06 15 873392 415 109715477
Gastrointestinal tract mucosal pigmentation 10.68 10.06 28 873379 1249 109714643
Renal cancer metastatic 10.65 10.06 21 873386 773 109715119
Parathyroid tumour benign 10.64 10.06 25 873382 1040 109714852
Hypertension 10.63 10.06 4324 869083 505760 109210132
Hypopnoea 10.63 10.06 137 873270 11243 109704649
Concomitant disease aggravated 10.60 10.06 185 873222 16179 109699713
Polyuria 10.60 10.06 198 873209 17540 109698352
Hypervitaminosis D 10.59 10.06 9 873398 138 109715754
Mitral valve prolapse 10.58 10.06 42 873365 2336 109713556
Petechiae 10.58 10.06 250 873157 23067 109692825
Injection site scar 10.58 10.06 26 873381 1114 109714778
Lipoma excision 10.54 10.06 9 873398 139 109715753
Haemorrhagic diathesis 10.53 10.06 98 873309 7410 109708482
Respiratory tract infection bacterial 10.53 10.06 3 873404 2413 109713479
Hyperplastic cholecystopathy 10.51 10.06 11 873396 222 109715670
Helplessness 10.50 10.06 14 873393 368 109715524
Energy increased 10.50 10.06 57 873350 3617 109712275
Anosognosia 10.49 10.06 10 873397 4064 109711828
Dental restoration failure 10.47 10.06 26 873381 1121 109714771
Arteriosclerosis 10.47 10.06 263 873144 24504 109691388
Patellofemoral pain syndrome 10.47 10.06 17 873390 536 109715356
Foetal exposure timing unspecified 10.47 10.06 7 873400 73 109715819
Electrocardiogram T wave abnormal 10.46 10.06 63 873344 4154 109711738
Clear cell sarcoma of soft tissue 10.46 10.06 4 873403 10 109715882
Haemorrhagic stroke 10.46 10.06 160 873247 13629 109702263
Autoimmune colitis 10.45 10.06 37 873370 1948 109713944
Large intestine infection 10.45 10.06 66 873341 4426 109711466
Overweight 10.43 10.06 87 873320 6377 109709515
Foreign body sensation in eyes 10.41 10.06 53 873354 3281 109712611
Platelet aggregation decreased 10.39 10.06 6 873401 47 109715845
Fracture blisters 10.39 10.06 7 873400 74 109715818
Tetany 10.36 10.06 56 873351 3548 109712344
Hypocholesterolaemia 10.34 10.06 22 873385 6399 109709493
Acromegaly 10.33 10.06 9 873398 143 109715749
Product supply issue 10.33 10.06 58 873349 3728 109712164
Hypoglossal nerve paralysis 10.33 10.06 5 873402 26 109715866
Product label issue 10.29 10.06 24 873383 994 109714898
Hepatitis B 10.29 10.06 40 873367 9572 109706320
Cerumen impaction 10.27 10.06 30 873377 1426 109714466
Lumbar radiculopathy 10.27 10.06 44 873363 2534 109713358
Mood altered 10.26 10.06 231 873176 21144 109694748
Blood pressure diastolic decreased 10.26 10.06 363 873044 35522 109680370
Food craving 10.26 10.06 37 873370 1966 109713926
Starvation ketoacidosis 10.25 10.06 13 873394 325 109715567
Blood glucose abnormal 10.24 10.06 151 873256 12765 109703127
Blood immunoglobulin M abnormal 10.23 10.06 9 873398 145 109715747
Skin toxicity 10.22 10.06 53 873354 11730 109704162
Chiasma syndrome 10.20 10.06 4 873403 11 109715881
Axillary pain 10.19 10.06 44 873363 2542 109713350
Osteocalcin decreased 10.19 10.06 6 873401 49 109715843
Metastases to neck 10.19 10.06 6 873401 49 109715843
Calcification metastatic 10.18 10.06 9 873398 146 109715746
Carotid artery stenosis 10.18 10.06 115 873292 9148 109706744
Tachycardia 10.18 10.06 1984 871423 224661 109491231
Calcification of muscle 10.16 10.06 10 873397 187 109715705
Melanocytic naevus 10.16 10.06 78 873329 5576 109710316
Infrequent bowel movements 10.16 10.06 39 873368 2136 109713756
Shock 10.15 10.06 334 873073 53254 109662638
Trigger finger 10.15 10.06 72 873335 5020 109710872
Neurodermatitis 10.15 10.06 48 873359 2884 109713008
Drug therapy 10.13 10.06 27 873380 7264 109708628
Peripheral vascular disorder 10.12 10.06 108 873299 8468 109707424
Chronic graft versus host disease in skin 10.11 10.06 4 873403 2615 109713277
Cardiac valve thickening 10.09 10.06 6 873401 50 109715842
Mycobacterial infection 10.08 10.06 12 873395 4405 109711487
Intercapillary glomerulosclerosis 10.07 10.06 8 873399 111 109715781

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 44.60 24.20 39 2911 4935 106068
Small for dates baby 32.98 24.20 185 2765 3555 107448
Atrial septal defect 26.45 24.20 174 2776 3539 107464
Oesophageal atresia 25.42 24.20 21 2929 80 110923

Pharmacologic Action:

SourceCodeDescription
ATC H03AA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
THYROID PREPARATIONS
Thyroid hormones
ATC H03AA51 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
THYROID PREPARATIONS
Thyroid hormones
FDA CS M0021504 Thyroxine
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35610 antineoplastic agent
FDA EPC N0000175945 l-Thyroxine
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:50671 antithyroid drug
CHEBI has role CHEBI:60311 thyroid hormone
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:52290 mitogen

Related Drugs by ATC class:

H03AA Thyroid hormones 2 drugs
liothyroninetiratricol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Goiter indication 3716002 DOID:12176
Hashimoto thyroiditis indication 21983002
Hypothyroidism indication 40930008 DOID:1459
Myxedema indication 43153006 DOID:11634
Hyperlipidemia indication 55822004 DOID:1168
Congenital hypothyroidism indication 190268003 DOID:0050328
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Diagnostic Test for Thyroid Dysfunction indication
Myxedema coma off-label use 21263006
Myocardial infarction contraindication 22298006 DOID:5844
Thyrotoxic crisis contraindication 29028009 DOID:12837
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Osteoporosis contraindication 64859006 DOID:11476
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Angina pectoris contraindication 194828000
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000
Disorder of coronary artery contraindication 414024009




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Replacement therapy for diminished thyroid function Indication

🐶 Veterinary products

ProductApplicantIngredients
Thyro-Tabs Canine Lloyd Inc. 1
ThyroKare Neogen Corp. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 6.63 acidic
pKa3 8.6 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
100MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
100MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
112MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
112MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
125MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
125MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
137MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
137MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
13MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
13MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
150MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
150MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
175MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
175MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
200MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
200MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
25MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
25MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
37.5MCG/ML TIROSINT-SOL IBSA N206977 Jan. 13, 2021 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
37.5MCG/ML TIROSINT-SOL IBSA N206977 Jan. 13, 2021 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
44MCG/ML TIROSINT-SOL IBSA N206977 Jan. 13, 2021 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
44MCG/ML TIROSINT-SOL IBSA N206977 Jan. 13, 2021 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
50MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
50MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
62.5MCG/ML TIROSINT-SOL IBSA N206977 Jan. 13, 2021 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
62.5MCG/ML TIROSINT-SOL IBSA N206977 Jan. 13, 2021 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
75MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
75MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
88MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF HYPOTHYROIDISM BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST
88MCG/ML TIROSINT-SOL IBSA N206977 Dec. 15, 2016 RX SOLUTION ORAL 11241382 Sept. 17, 2039 TREATMENT OF PITUITARY THYROTROPIN SUPPRESSION BY ORAL ADMINISTRATION OF L-THYROXINE TO A PATIENT ON AN EMPTY STOMACH 15 MINUTES BEFORE BREAKFAST

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thyroid hormone receptor alpha Nuclear hormone receptor AGONIST EC50 7.72 CHEMBL IUPHAR
Thyroid hormone receptor beta Nuclear hormone receptor AGONIST IC50 8.52 IUPHAR CHEMBL
Transthyretin Secreted IC50 4.98 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor Kd 6.40 CHEMBL
Retinoic acid receptor RXR-alpha Nuclear hormone receptor Kd 6.03 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.10 CHEMBL
THAP domain-containing protein 1 Transcription factor WOMBAT-PK
Macrophage migration inhibitory factor Cytokine IC50 4.80 CHEMBL
Malate dehydrogenase, mitochondrial Enzyme IC50 4.36 CHEMBL
Thyroid hormone receptor beta Transcription factor IC50 7.46 CHEMBL

External reference:

IDSource
4017826 VUID
N0000179290 NUI
D01010 KEGG_DRUG
55-03-8 SECONDARY_CAS_RN
6106-07-6 SECONDARY_CAS_RN
4017826 VANDF
4022126 VANDF
CHEBI:18332 CHEBI
CHEMBL1624 ChEMBL_ID
CHEMBL2103741 ChEMBL_ID
CHEMBL42115 ChEMBL_ID
DB00451 DRUGBANK_ID
10582 RXNORM
1842 MMSL
4976 MMSL
d00278 MMSL
002132 NDDF
004881 NDDF
005896 NDDF
126202002 SNOMEDCT_US
38076006 SNOMEDCT_US
710809001 SNOMEDCT_US
73187006 SNOMEDCT_US
768532006 SNOMEDCT_US
783637002 SNOMEDCT_US
C0040165 UMLSCUI
D013974 MESH_DESCRIPTOR_UI
T44 PDB_CHEM_ID
453 INN_ID
5819 PUBCHEM_CID
Q51BO43MG4 UNII
Q51BO43MG4 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-3727 TABLET 137 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4341 TABLET 25 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4552 TABLET 50 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-5182 TABLET 75 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6594 TABLET 88 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6624 TABLET 100 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7068 TABLET 125 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7069 TABLET 150 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7070 TABLET 175 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7148 TABLET 200 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7149 TABLET 300 ug ORAL NDA 27 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-9296 TABLET 112 ug ORAL NDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1800 TABLET 25 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1803 TABLET 50 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1805 TABLET 75 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1807 TABLET 88 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1809 TABLET 100 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1811 TABLET 112 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1813 TABLET 125 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1815 TABLET 150 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1817 TABLET 175 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1819 TABLET 200 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1821 TABLET 300 ug ORAL ANDA 27 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1823 TABLET 137 ug ORAL ANDA 27 sections
Levothyroxine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-8682 TABLET 25 ug ORAL ANDA 26 sections
Levothyroxine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-8682 TABLET 25 ug ORAL ANDA 26 sections
Levothyroxine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-8687 TABLET 50 ug ORAL ANDA 26 sections
Levothyroxine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-8687 TABLET 50 ug ORAL ANDA 26 sections
Levothyroxine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-8690 TABLET 75 ug ORAL ANDA 26 sections
Levothyroxine sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-8690 TABLET 75 ug ORAL ANDA 26 sections