levothyroxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2646 51-48-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levothyroxine sodium anhydrous
  • levothyroxine sodium pentahydrate
  • L-Thyroxine
  • thyroxin sodium
  • thyroxine sodium
  • levothyroxine sodium
  • tetraiodothyronine
  • thyroxine
  • levothyroxine
  • levothyroxin natrium
  • T4
  • levothyroxine sodium hydrate
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
  • Molecular weight: 776.87
  • Formula: C15H11I4NO4
  • CLOGP: 3.21
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 3
  • TPSA: 92.78
  • ALOGS: -4.94
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 mg O
0.15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Aug. 21, 2000 FDA STEVENS J
Jan. 23, 2020 PMDA Aska Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1551.56 10.38 71 662961 157141 55471894
Systemic lupus erythematosus 1236.78 10.38 300 662732 179778 55449257
Rheumatoid arthritis 1188.77 10.38 1666 661366 380938 55248097
Glossodynia 1143.41 10.38 207 662825 152251 55476784
Hypothyroidism 1097.41 10.38 1764 661268 36432 55592603
Contraindicated product administered 1060.82 10.38 433 662599 185853 55443182
Drug ineffective 985.83 10.38 6574 656458 912415 54716620
Hand deformity 961.36 10.38 205 662827 134287 55494748
Blood thyroid stimulating hormone increased 930.99 10.38 705 662327 5858 55623177
Anti-cyclic citrullinated peptide antibody positive 876.30 10.38 77 662955 98523 55530512
Synovitis 861.36 10.38 411 662621 160894 55468141
Treatment failure 856.47 10.38 470 662562 169922 55459113
Pericarditis 790.82 10.38 160 662872 108763 55520272
Drug intolerance 716.00 10.38 1264 661768 263554 55365481
Infusion related reaction 711.39 10.38 848 662184 208083 55420952
Arthropathy 707.68 10.38 789 662243 199486 55429549
Wound 681.40 10.38 394 662638 138410 55490625
Maternal exposure during pregnancy 626.60 10.38 787 662245 188766 55440269
Duodenal ulcer perforation 581.87 10.38 63 662969 68279 55560756
Rheumatoid factor positive 555.31 10.38 77 662955 68983 55560052
Therapeutic product effect decreased 537.92 10.38 725 662307 168727 55460308
Discomfort 511.01 10.38 549 662483 141212 55487823
Abdominal discomfort 500.95 10.38 1636 661396 275638 55353397
Helicobacter infection 489.21 10.38 129 662903 73139 55555896
Swelling 469.78 10.38 1363 661669 238408 55390627
Hepatic enzyme increased 449.37 10.38 833 662199 170551 55458484
Folliculitis 440.37 10.38 62 662970 54917 55574118
Joint swelling 430.85 10.38 1852 661180 287948 55341087
Muscle injury 428.11 10.38 56 662976 52444 55576591
Drug hypersensitivity 420.03 10.38 1741 661291 273464 55355571
Off label use 411.31 10.38 4380 658652 551800 55077235
Lower respiratory tract infection 395.65 10.38 461 662571 114333 55514702
Alopecia 382.85 10.38 1966 661066 291492 55337543
Blood thyroid stimulating hormone abnormal 352.46 10.38 179 662853 645 55628390
Sleep disorder due to general medical condition, insomnia type 328.65 10.38 57 662975 43281 55585754
Hypersensitivity 321.89 10.38 1740 661292 254668 55374367
Fall 317.07 10.38 5941 657091 351569 55277466
Product use issue 315.76 10.38 1127 661905 184914 55444121
Hyperthyroidism 314.96 10.38 565 662467 12787 55616248
Blood thyroid stimulating hormone decreased 293.15 10.38 306 662726 4027 55625008
Irritable bowel syndrome 264.98 10.38 249 662783 68209 55560826
Exposure during pregnancy 244.76 10.38 806 662226 135536 55493499
Thyroid function test abnormal 235.05 10.38 244 662788 3189 55625846
Asthenia 213.05 10.38 5416 657616 337557 55291478
Completed suicide 209.90 10.38 837 662195 132996 55496039
Infection 207.53 10.38 1442 661590 198764 55430271
Blood thyroid stimulating hormone normal 206.78 10.38 71 662961 52 55628983
Impaired healing 199.52 10.38 455 662577 86386 55542649
Pain 197.68 10.38 6130 656902 657054 54971981
Blister 196.57 10.38 642 662390 108245 55520790
Palpitations 189.63 10.38 1901 661131 97771 55531264
Product substitution issue 187.87 10.38 483 662549 14116 55614919
Dizziness 186.65 10.38 5772 657260 370368 55258667
Thyroid disorder 185.46 10.38 467 662565 13471 55615564
Toxicity to various agents 183.73 10.38 1724 661308 222840 55406195
Myalgia 180.44 10.38 2361 660671 129664 55499371
Gastrointestinal disorder 165.43 10.38 723 662309 111979 55517056
Ill-defined disorder 164.12 10.38 351 662681 68192 55560843
Hyponatraemia 163.55 10.38 1882 661150 100257 55528778
Rash 162.48 10.38 4494 658538 488553 55140482
Stomatitis 146.88 10.38 828 662204 119982 55509053
Rheumatic fever 146.86 10.38 78 662954 28749 55600286
Musculoskeletal stiffness 145.66 10.38 1157 661875 154850 55474185
Muscle spasms 143.98 10.38 2346 660686 135025 55494010
Swollen joint count increased 141.09 10.38 54 662978 24130 55604905
Drug abuse 139.82 10.38 374 662658 67236 55561799
Balance disorder 138.14 10.38 1444 661588 75076 55553959
Constipation 136.52 10.38 3227 659805 198716 55430319
Feeling abnormal 135.35 10.38 2269 660763 131333 55497702
Atrial fibrillation 130.29 10.38 1902 661130 106995 55522040
Febrile neutropenia 122.61 10.38 734 662298 104811 55524224
C-reactive protein abnormal 122.30 10.38 152 662880 36657 55592378
Product use in unapproved indication 120.33 10.38 1069 661963 139753 55489282
Drug resistance 114.73 10.38 49 662983 20493 55608542
Orthostatic hypotension 111.26 10.38 721 662311 32478 55596557
Vertigo 110.66 10.38 1055 661977 53517 55575518
Hip arthroplasty 107.16 10.38 181 662851 38442 55590593
Product prescribing error 105.42 10.38 546 662486 22640 55606395
Intentional product use issue 103.88 10.38 717 662315 99016 55530019
Drug tolerance decreased 103.08 10.38 17 663015 13394 55615641
Syncope 101.77 10.38 1816 661216 106383 55522652
Intentional overdose 101.74 10.38 434 662598 67683 55561352
Dysgeusia 101.08 10.38 826 662206 40089 55588946
Vision blurred 96.95 10.38 1443 661589 81500 55547535
Psoriatic arthropathy 93.33 10.38 501 662531 73507 55555528
Red blood cell sedimentation rate abnormal 91.54 10.38 53 662979 18620 55610415
Autoimmune thyroiditis 90.32 10.38 156 662876 3422 55625613
Therapy non-responder 88.54 10.38 396 662636 60959 55568076
Blood calcium decreased 88.27 10.38 530 662502 23239 55605796
Nasopharyngitis 87.97 10.38 1957 661075 219002 55410033
Cognitive disorder 85.75 10.38 921 662111 48212 55580823
Condition aggravated 85.53 10.38 3260 659772 341638 55287397
Product complaint 84.82 10.38 318 662714 11442 55617593
Cytomegalovirus infection 84.76 10.38 62 662970 19234 55609801
Tremor 84.20 10.38 1943 661089 119146 55509889
Disturbance in attention 83.13 10.38 662 662370 31878 55597157
Transplant rejection 82.42 10.38 10 663022 9924 55619111
Product quality issue 82.37 10.38 648 662384 31088 55597947
Dysphagia 81.93 10.38 1389 661643 80558 55548477
Liver injury 80.23 10.38 240 662792 41608 55587427
Myelosuppression 76.78 10.38 56 662976 17399 55611636
Sedation complication 76.34 10.38 306 662726 11366 55617669
Dehydration 76.05 10.38 2428 660604 156397 55472638
Pyrexia 75.85 10.38 4096 658936 414677 55214358
Therapeutic product effect incomplete 75.47 10.38 841 662191 105190 55523845
Knee arthroplasty 75.04 10.38 268 662764 43991 55585044
Creatinine renal clearance decreased 74.82 10.38 355 662677 14204 55614831
Nausea 73.52 10.38 10167 652865 754011 54875024
Therapeutic response unexpected 72.45 10.38 394 662638 16650 55612385
Hepatic function abnormal 71.56 10.38 191 662841 34367 55594668
Product formulation issue 71.00 10.38 56 662976 497 55628538
Hyperhidrosis 70.84 10.38 1527 661505 92561 55536474
Thyroid cancer 68.67 10.38 172 662860 4944 55624091
Oedema peripheral 68.21 10.38 2563 660469 168691 55460344
Weight decreased 67.60 10.38 3475 659557 237239 55391796
Adrenocortical insufficiency acute 67.05 10.38 86 662946 1430 55627605
Transient ischaemic attack 66.03 10.38 645 662387 32932 55596103
Dry skin 62.84 10.38 839 662193 46270 55582765
Sensitisation 62.09 10.38 105 662927 2263 55626772
Diarrhoea 62.03 10.38 8501 654531 630006 54999029
Panniculitis 60.79 10.38 20 663012 9822 55619213
Hot flush 60.61 10.38 828 662204 45898 55583137
Peripheral swelling 60.25 10.38 2209 660823 232517 55396518
Malaise 58.43 10.38 5061 657971 362799 55266236
Muscular weakness 58.42 10.38 1628 661404 102824 55526211
Craniopharyngioma 58.06 10.38 31 663001 127 55628908
Blood pressure increased 56.43 10.38 2167 660865 143009 55486026
Pregnancy 56.01 10.38 200 662832 32833 55596202
Bone marrow failure 55.83 10.38 160 662872 28126 55600909
Anxiety 55.09 10.38 2793 660239 190379 55438656
Nervousness 54.93 10.38 553 662479 28462 55600573
Death 54.78 10.38 3378 659654 338048 55290987
Insulin-like growth factor increased 54.47 10.38 59 662973 812 55628223
Sinusitis 54.22 10.38 1844 661188 195737 55433298
Dry mouth 53.90 10.38 1059 661973 63146 55565889
Schizoaffective disorder 53.87 10.38 112 662920 2837 55626198
Rheumatoid nodule 52.95 10.38 58 662974 14799 55614236
Hypoglycaemia 52.87 10.38 938 662094 54877 55574158
Headache 52.62 10.38 7430 655602 551614 55077421
Thyroidectomy 51.99 10.38 63 662969 986 55628049
Cardio-respiratory arrest 51.70 10.38 410 662622 54911 55574124
Visual impairment 51.66 10.38 1191 661841 73011 55556024
Blood parathyroid hormone decreased 51.65 10.38 17 663015 8347 55620688
Adverse event 51.02 10.38 412 662620 54964 55574071
Reaction to excipient 50.86 10.38 69 662963 1215 55627820
Blood glucose increased 50.71 10.38 1201 661831 73950 55555085
Insomnia 49.87 10.38 2750 660282 189110 55439925
Hepatotoxicity 48.68 10.38 195 662837 30958 55598077
Arrhythmia 47.69 10.38 627 662405 34456 55594579
Myxoedema coma 47.63 10.38 39 662993 367 55628668
Product monitoring error 47.17 10.38 117 662915 3342 55625693
Flatulence 47.15 10.38 570 662462 30718 55598317
Enthesopathy 47.04 10.38 18 663014 8045 55620990
Gastrooesophageal reflux disease 46.08 10.38 1296 661736 81961 55547074
Bone erosion 45.51 10.38 66 662966 14908 55614127
Urinary tract infection 45.11 10.38 3352 659680 237161 55391874
Thyroxine increased 44.93 10.38 45 662987 562 55628473
Dysphonia 44.87 10.38 719 662313 41228 55587807
Joint destruction 44.74 10.38 4 663028 5051 55623984
Bone pain 43.56 10.38 832 662200 49353 55579682
Thyroxine free increased 43.44 10.38 52 662980 803 55628232
Oral pain 43.18 10.38 487 662545 25806 55603229
Haemophagocytic lymphohistiocytosis 43.03 10.38 30 663002 9542 55619493
Neurotoxicity 42.91 10.38 75 662957 15720 55613315
Therapeutic drug monitoring analysis not performed 42.87 10.38 56 662976 949 55628086
Cerebral haematoma 42.81 10.38 110 662922 3213 55625822
Myxoedema 42.57 10.38 22 663010 83 55628952
Disease progression 41.94 10.38 931 662101 104242 55524793
Gait disturbance 41.85 10.38 2338 660694 160983 55468052
Thyroid hormones increased 41.54 10.38 35 662997 344 55628691
Transplant dysfunction 41.35 10.38 4 663028 4742 55624293
Swollen tongue 41.24 10.38 542 662490 29782 55599253
Neutropenia 41.11 10.38 1486 661546 156681 55472354
Full blood count abnormal 40.71 10.38 484 662548 25978 55603057
Device expulsion 40.70 10.38 202 662830 30247 55598788
Amnesia 40.56 10.38 769 662263 45553 55583482
Infective pulmonary exacerbation of cystic fibrosis 40.20 10.38 23 663009 8134 55620901
Device difficult to use 39.48 10.38 41 662991 10720 55618315
Red blood cell sedimentation rate 39.26 10.38 3 663029 4305 55624730
Tri-iodothyronine decreased 39.11 10.38 23 663009 118 55628917
Sedation 39.01 10.38 602 662430 34252 55594783
Multiple organ dysfunction syndrome 38.95 10.38 415 662617 52355 55576680
Therapeutic response decreased 38.90 10.38 415 662617 52343 55576692
Acute kidney injury 38.87 10.38 3317 659715 237446 55391589
Product solubility abnormal 38.81 10.38 47 662985 735 55628300
C-reactive protein increased 38.81 10.38 672 662360 78012 55551023
Retinitis 38.33 10.38 3 663029 4221 55624814
Pulmonary malformation 38.11 10.38 28 663004 221 55628814
Haematotoxicity 38.05 10.38 26 663006 8357 55620678
Abdominal distension 37.72 10.38 1189 661843 76437 55552598
Toxic epidermal necrolysis 37.67 10.38 133 662899 21909 55607126
Diffuse alopecia 37.63 10.38 42 662990 599 55628436
Angina pectoris 37.62 10.38 499 662533 27477 55601558
Pathogen resistance 37.40 10.38 12 663020 5988 55623047
Cardiac disorder 37.22 10.38 753 662279 45134 55583901
Accidental exposure to product 36.81 10.38 157 662875 24490 55604545
Decreased appetite 36.75 10.38 3029 660003 216202 55412833
Hypersomnia 36.70 10.38 323 662709 16018 55613017
Live birth 36.46 10.38 114 662918 19491 55609544
Pituitary tumour recurrent 36.31 10.38 19 663013 74 55628961
Anaphylactic reaction 36.23 10.38 483 662549 58512 55570523
Breast cancer stage I 36.19 10.38 14 663018 6216 55622819
Mucosal inflammation 36.08 10.38 326 662706 42484 55586551
Device adhesion issue 35.92 10.38 5 663027 4469 55624566
Product administration error 35.90 10.38 391 662641 20538 55608497
Post transplant lymphoproliferative disorder 35.73 10.38 6 663026 4666 55624369
Type 2 diabetes mellitus 35.62 10.38 366 662666 46496 55582539
Ageusia 35.54 10.38 260 662772 12191 55616844
Venoocclusive liver disease 35.36 10.38 5 663027 4416 55624619
Bradycardia 35.21 10.38 1043 661989 66461 55562574
Exophthalmos 34.82 10.38 58 662974 1234 55627801
Memory impairment 34.08 10.38 1294 661738 85263 55543772
Hypoacusis 33.87 10.38 399 662633 21369 55607666
Disability 33.59 10.38 86 662946 15694 55613341
Ejection fraction 33.54 10.38 67 662965 1648 55627387
Haematochezia 33.36 10.38 711 662321 43007 55586028
Blood thyroid stimulating hormone 33.27 10.38 11 663021 6 55629029
Reversible airways obstruction 33.19 10.38 59 662973 1325 55627710
Jaw disorder 33.03 10.38 133 662899 4950 55624085
Eye irritation 32.87 10.38 356 662676 18672 55610363
Suicide attempt 32.85 10.38 481 662551 57355 55571680
Anti-cyclic citrullinated peptide antibody 32.81 10.38 3 663029 3720 55625315
Breast cancer stage III 32.80 10.38 22 663010 7141 55621894
Hip fracture 32.57 10.38 472 662560 26501 55602534
Pain in extremity 32.40 10.38 3989 659043 293442 55335593
Papillary thyroid cancer 32.36 10.38 75 662957 2049 55626986
Polycystic ovaries 32.18 10.38 99 662933 3215 55625820
Disorientation 32.12 10.38 608 662424 36005 55593030
Liver function test abnormal 32.07 10.38 734 662298 44937 55584098
Systemic infection 32.06 10.38 98 662934 3171 55625864
Lactose intolerance 31.93 10.38 86 662946 2586 55626449
Breast cancer stage II 31.73 10.38 14 663018 5744 55623291
Pulmonary embolism 31.56 10.38 1554 661478 105570 55523465
Deep vein thrombosis 31.56 10.38 1156 661876 75821 55553214
Thyroid hormones decreased 31.55 10.38 28 663004 297 55628738
Milk-alkali syndrome 31.51 10.38 40 662992 658 55628377
Sickle cell anaemia with crisis 31.44 10.38 10 663022 5018 55624017
Depression 31.37 10.38 2496 660536 177621 55451414
Chest discomfort 31.23 10.38 1444 661588 97413 55531622
Unintentional medical device removal 31.14 10.38 14 663018 5680 55623355
Thyroxine abnormal 31.08 10.38 9 663023 0 55629035
Hyperkalaemia 31.06 10.38 802 662230 50063 55578972
Respiratory arrest 30.97 10.38 222 662810 30403 55598632
Influenza like illness 30.91 10.38 939 662093 60049 55568986
Renal disorder 30.74 10.38 505 662527 29100 55599935
Malabsorption 30.68 10.38 107 662925 3714 55625321
Multiple-drug resistance 30.63 10.38 5 663027 3969 55625066
Septic shock 30.50 10.38 518 662514 60317 55568718
Incorrect dose administered 30.49 10.38 823 662209 51724 55577311
Product measured potency issue 30.36 10.38 18 663014 94 55628941
Product taste abnormal 30.24 10.38 68 662964 1820 55627215
Arthralgia 30.00 10.38 5326 657706 496343 55132692
Ankylosing spondylitis 29.95 10.38 44 662988 9886 55619149
Chest pain 29.86 10.38 2610 660422 187187 55441848
Product odour abnormal 29.78 10.38 50 662982 1071 55627964
International normalised ratio increased 29.75 10.38 704 662328 43337 55585698
Eye swelling 29.46 10.38 383 662649 20993 55608042
Carpal tunnel syndrome 29.31 10.38 335 662697 17809 55611226
Juvenile idiopathic arthritis 28.95 10.38 10 663022 4763 55624272
Gestational diabetes 28.79 10.38 178 662854 7886 55621149
Papillitis 28.70 10.38 11 663021 15 55629020
Soft tissue disorder 28.60 10.38 113 662919 4169 55624866
Overdose 28.47 10.38 990 662042 104840 55524195
Rhinitis allergic 28.36 10.38 184 662848 8290 55620745
Product colour issue 28.16 10.38 35 662997 563 55628472
Body height decreased 28.08 10.38 195 662837 8990 55620045
Pancreatic neuroendocrine tumour 28.03 10.38 30 663002 407 55628628
Blood glucose decreased 28.01 10.38 346 662686 18741 55610294
Paraesthesia 27.92 10.38 1839 661193 128675 55500360
Atrioventricular block 27.80 10.38 157 662875 6730 55622305
Cerebrovascular accident 27.58 10.38 1432 661600 97838 55531197
Inner ear disorder 27.57 10.38 31 663001 446 55628589
Thyrotoxic crisis 27.52 10.38 41 662991 790 55628245
Product physical issue 27.50 10.38 117 662915 4465 55624570
Inflammation 27.36 10.38 612 662420 68459 55560576
Impaired driving ability 27.28 10.38 108 662924 3988 55625047
Stillbirth 27.25 10.38 20 663012 6194 55622841
Lip swelling 27.23 10.38 448 662584 25824 55603211
Autoimmune hepatitis 27.13 10.38 173 662859 7748 55621287
Neutrophil count decreased 27.04 10.38 418 662614 49404 55579631
Trichorrhexis 27.03 10.38 49 662983 1118 55627917
Pollakiuria 26.95 10.38 432 662600 24770 55604265
Adenovirus infection 26.92 10.38 4 663028 3404 55625631
Choking 26.91 10.38 190 662842 8807 55620228
Gastrointestinal toxicity 26.75 10.38 20 663012 6136 55622899
Skin haemorrhage 26.54 10.38 180 662852 8233 55620802
Feeling cold 26.48 10.38 373 662659 20814 55608221
Anaemia 26.48 10.38 3567 659465 263944 55365091
Foreign body in reproductive tract 26.28 10.38 31 663001 471 55628564
Swelling face 26.24 10.38 855 662177 55214 55573821
Low turnover osteopathy 26.15 10.38 105 662927 3903 55625132
Pneumocystis jirovecii pneumonia 26.00 10.38 96 662936 15605 55613430
Nephritic syndrome 25.91 10.38 23 663009 244 55628791
Therapeutic product effect increased 25.52 10.38 45 662987 1004 55628031
Hypertensive crisis 25.37 10.38 265 662767 13771 55615264
Congenital absence of vertebra 25.23 10.38 12 663020 36 55628999
Dementia 25.16 10.38 311 662721 16847 55612188
Haematoma 25.16 10.38 523 662509 31496 55597539
Tinnitus 25.03 10.38 495 662537 29547 55599488
Tenosynovitis 24.95 10.38 70 662962 12391 55616644
Gastritis 24.77 10.38 559 662473 34143 55594892
Renal dysplasia 24.71 10.38 18 663014 140 55628895
Somatic delusion 24.60 10.38 32 663000 540 55628495
Cytomegalovirus infection reactivation 24.47 10.38 4 663028 3172 55625863
Abortion spontaneous 24.46 10.38 365 662667 43388 55585647
Macular degeneration 24.38 10.38 127 662905 18781 55610254
Premature labour 24.35 10.38 66 662966 11816 55617219
Head discomfort 24.21 10.38 232 662800 11782 55617253
Premature baby 24.20 10.38 130 662902 19075 55609960
Cataract 24.12 10.38 782 662250 50465 55578570
Cardiac arrest 24.01 10.38 804 662228 85510 55543525
Lung cyst 23.88 10.38 23 663009 273 55628762
Thyroid cancer recurrent 23.87 10.38 11 663021 30 55629005
Dyspnoea exertional 23.82 10.38 827 662205 53862 55575173
Goitre 23.80 10.38 129 662903 5444 55623591
Spinal stenosis 23.66 10.38 261 662771 13753 55615282
Hypopituitarism 23.60 10.38 43 662989 985 55628050
Insulin-like growth factor decreased 23.55 10.38 26 663006 366 55628669
Blood loss anaemia 23.54 10.38 173 662859 8124 55620911
Thrombotic microangiopathy 23.52 10.38 47 662985 9364 55619671
Respiratory disorder 23.49 10.38 271 662761 33686 55595349
Withdrawal syndrome 23.46 10.38 326 662706 18136 55610899
Haemorrhoids 23.38 10.38 351 662681 19855 55609180
Ischaemic stroke 23.31 10.38 302 662730 16540 55612495
Presbyacusis 23.20 10.38 3 663029 2835 55626200
Fatigue 23.18 10.38 9947 653085 778605 54850430
Scleral discolouration 23.18 10.38 26 663006 373 55628662
Pneumonia viral 23.09 10.38 154 662878 7004 55622031
Oral discomfort 23.01 10.38 173 662859 8182 55620853
Cardiac pacemaker insertion 22.92 10.38 97 662935 3693 55625342
Product dispensing error 22.86 10.38 187 662845 9077 55619958
Extremity contracture 22.69 10.38 48 662984 1231 55627804
Tenderness 22.51 10.38 348 662684 19807 55609228
Eye pain 22.36 10.38 498 662534 30349 55598686
Hyperlipidaemia 22.30 10.38 318 662714 17791 55611244
Arteriosclerosis coronary artery 22.29 10.38 163 662869 7642 55621393
Listless 22.26 10.38 75 662957 2557 55626478
Speech disorder 22.26 10.38 589 662443 36904 55592131
Recalled product 22.24 10.38 50 662982 1338 55627697
Gastrointestinal motility disorder 22.21 10.38 112 662920 4594 55624441
Skin necrosis 22.20 10.38 73 662959 12288 55616747
Thyrotoxic periodic paralysis 22.07 10.38 9 663023 16 55629019
Ventricular hypertrophy 22.07 10.38 86 662946 3152 55625883
Gallbladder disorder 22.00 10.38 306 662726 17028 55612007
Product dose omission issue 22.00 10.38 2744 660288 202009 55427026
Tooth fracture 21.99 10.38 201 662831 10075 55618960
Small for dates baby 21.86 10.38 91 662941 3439 55625596
Maternal exposure timing unspecified 21.84 10.38 19 663013 5404 55623631
Coronary artery occlusion 21.83 10.38 161 662871 7568 55621467
Coma 21.83 10.38 535 662497 59120 55569915
Pelvic fracture 21.80 10.38 230 662802 11983 55617052
Graft versus host disease in skin 21.79 10.38 3 663029 2704 55626331
Hypophysitis 21.78 10.38 55 662977 1589 55627446
Sprue-like enteropathy 21.63 10.38 30 663002 540 55628495
Somnolence 21.49 10.38 2219 660813 161194 55467841
Disseminated intravascular coagulation 21.48 10.38 123 662909 17762 55611273
Diverticulum 21.47 10.38 212 662820 10854 55618181
Dry eye 21.47 10.38 562 662470 35154 55593881
Broncholithiasis 21.22 10.38 19 663013 204 55628831
Vitamin D deficiency 21.16 10.38 228 662804 11942 55617093
Micturition urgency 21.00 10.38 176 662856 8605 55620430
Glomerular filtration rate decreased 20.99 10.38 230 662802 12099 55616936
Thrombosis 20.96 10.38 878 662154 58549 55570486
Lethargy 20.96 10.38 772 662260 50669 55578366
Hyperglycaemia 20.92 10.38 595 662437 37686 55591349
Ecchymosis 20.88 10.38 200 662832 10156 55618879
Rapid eye movement sleep behaviour disorder 20.80 10.38 18 663014 184 55628851
Acute graft versus host disease in skin 20.69 10.38 6 663026 3196 55625839
Dyspnoea 20.62 10.38 7520 655512 585057 55043978
Bundle branch block left 20.60 10.38 137 662895 6225 55622810
Dislocation of vertebra 20.59 10.38 20 663012 5395 55623640
Labelled drug-drug interaction medication error 20.59 10.38 218 662814 11368 55617667
Substance abuse 20.58 10.38 14 663018 4511 55624524
Head injury 20.54 10.38 412 662620 24654 55604381
Cytomegalovirus viraemia 20.54 10.38 18 663014 5102 55623933
Muscle spasticity 20.52 10.38 144 662888 19816 55609219
Drug use disorder 20.51 10.38 15 663017 4654 55624381
Drug interaction 20.50 10.38 2795 660237 206960 55422075
Graft versus host disease 20.50 10.38 30 663002 6751 55622284
Congenital renal cyst 20.46 10.38 7 663025 5 55629030
Therapeutic product effect variable 20.37 10.38 43 662989 1101 55627934
Burning sensation 20.37 10.38 733 662299 47963 55581072
Hypotension 20.35 10.38 3303 659729 247205 55381830
X-ray abnormal 20.33 10.38 13 663019 4328 55624707
Arterial occlusive disease 20.32 10.38 121 662911 5289 55623746
Urinary incontinence 20.31 10.38 474 662558 29111 55599924
Full blood count decreased 20.22 10.38 387 662645 22962 55606073
Vital capacity decreased 20.20 10.38 46 662986 1242 55627793
Cardiotoxicity 20.18 10.38 37 662995 7613 55621422
Blood creatine abnormal 20.16 10.38 14 663018 100 55628935
Body temperature increased 20.07 10.38 283 662749 33959 55595076
Pituitary tumour benign 20.04 10.38 59 662973 1869 55627166
Intervertebral disc protrusion 19.98 10.38 363 662669 21331 55607704
Electrocardiogram ST-T segment abnormal 19.96 10.38 21 663011 279 55628756
Intentional self-injury 19.90 10.38 193 662839 24799 55604236
Thyroxine free decreased 19.87 10.38 31 663001 623 55628412
Blood insulin increased 19.67 10.38 15 663017 126 55628909
Chromaturia 19.64 10.38 271 662761 15054 55613981
Hiatus hernia 19.59 10.38 333 662699 19319 55609716
Thinking abnormal 19.56 10.38 191 662841 9750 55619285
Incorrect route of product administration 19.50 10.38 159 662873 21170 55607865
Adenomatous polyposis coli 19.49 10.38 10 663022 37 55628998
Chronic graft versus host disease 19.45 10.38 7 663025 3249 55625786
Respiratory tract malformation 19.42 10.38 16 663016 152 55628883
Tongue discomfort 19.36 10.38 60 662972 1956 55627079
Subdural hygroma 19.31 10.38 19 663013 232 55628803
Blood sodium decreased 19.28 10.38 370 662662 21964 55607071
Dyspepsia 19.28 10.38 1184 661848 82287 55546748
Change of bowel habit 18.99 10.38 61 662971 2028 55627007
Neuromyopathy 18.90 10.38 29 663003 574 55628461
Foetal death 18.90 10.38 46 662986 8541 55620494
Pulmonary tuberculosis 18.87 10.38 15 663017 4461 55624574
Feeling jittery 18.83 10.38 221 662811 11825 55617210
Blood calcium increased 18.74 10.38 162 662870 7992 55621043
Lymphadenectomy 18.74 10.38 37 662995 902 55628133
Hypertension 18.74 10.38 3211 659821 241067 55387968
Persistent depressive disorder 18.73 10.38 36 662996 860 55628175
Abortion induced 18.71 10.38 55 662977 9590 55619445
Anosmia 18.68 10.38 102 662930 4317 55624718
Nephrectomy 18.67 10.38 43 662989 1170 55627865
Exposure to toxic agent 18.66 10.38 10 663022 3668 55625367
Red blood cell sedimentation rate increased 18.63 10.38 311 662721 36312 55592723
Therapy partial responder 18.51 10.38 40 662992 7745 55621290
Paradoxical drug reaction 18.50 10.38 11 663021 3809 55625226
Poisoning deliberate 18.42 10.38 58 662974 9895 55619140
Glycosylated haemoglobin increased 18.42 10.38 207 662825 10958 55618077
Bronchopulmonary aspergillosis 18.40 10.38 44 662988 8220 55620815
Cytokine release syndrome 18.33 10.38 66 662966 10809 55618226
Genital swelling 18.32 10.38 14 663018 118 55628917
Prescribed overdose 18.26 10.38 171 662861 22125 55606910
Back pain 18.24 10.38 3118 659914 234052 55394983
Dysstasia 18.23 10.38 325 662707 19029 55610006
Cardiac failure congestive 18.21 10.38 1233 661799 86487 55542548
Muscle fatigue 18.19 10.38 65 662967 2284 55626751
Endocrine ophthalmopathy 18.18 10.38 26 663006 482 55628553
Cystitis haemorrhagic 18.15 10.38 12 663020 3925 55625110
Thyroxine decreased 18.05 10.38 29 663003 598 55628437
Dilatation atrial 18.05 10.38 56 662976 1827 55627208
Rectal haemorrhage 18.04 10.38 627 662405 40840 55588195
Epstein-Barr virus infection 18.04 10.38 38 662994 7425 55621610
Neutropenic sepsis 17.94 10.38 105 662927 15080 55613955
Eating disorder 17.84 10.38 292 662740 16813 55612222
Abnormal dreams 17.83 10.38 183 662849 9466 55619569
Foot deformity 17.73 10.38 187 662845 23638 55605397
Aortic valve incompetence 17.66 10.38 120 662912 5492 55623543
Diabetes mellitus inadequate control 17.42 10.38 246 662786 13734 55615301
Pancreatitis acute 17.39 10.38 403 662629 24721 55604314
Blood growth hormone increased 17.38 10.38 24 663008 430 55628605
Drug level changed 17.38 10.38 17 663015 206 55628829
Vessel puncture site haemorrhage 17.36 10.38 13 663019 106 55628929
Application site erythema 17.35 10.38 103 662929 4497 55624538
Supraventricular extrasystoles 17.35 10.38 95 662937 4025 55625010
Neonatal thyrotoxicosis 17.27 10.38 5 663027 0 55629035
Hair texture abnormal 17.24 10.38 91 662941 3801 55625234
Adverse drug reaction 17.11 10.38 611 662421 64521 55564514
Bundle branch block right 17.08 10.38 105 662927 4642 55624393
Temperature intolerance 17.07 10.38 157 662875 7883 55621152
Femur fracture 17.06 10.38 594 662438 38701 55590334
Arrhythmia neonatal 17.02 10.38 9 663023 36 55628999
Diabetes mellitus 17.01 10.38 772 662260 51963 55577072
Oropharyngeal swelling 17.00 10.38 34 662998 837 55628198
Product residue present 16.99 10.38 89 662943 3706 55625329
International normalised ratio abnormal 16.94 10.38 75 662957 2913 55626122
Anaemia postoperative 16.90 10.38 60 662972 2101 55626934
Joint laxity 16.84 10.38 4 663028 2435 55626600
Exposure via ingestion 16.83 10.38 6 663026 2802 55626233
Tooth dislocation 16.82 10.38 8 663024 24 55629011
Sleep apnoea syndrome 16.82 10.38 414 662618 25647 55603388
Scar 16.81 10.38 222 662810 12211 55616824
Product packaging issue 16.81 10.38 37 662995 976 55628059
Skin ulcer 16.77 10.38 337 662695 38271 55590764
Skin abrasion 16.75 10.38 164 662868 8377 55620658
Fear of injection 16.75 10.38 32 663000 6483 55622552
Starvation ketoacidosis 16.73 10.38 11 663021 71 55628964
Depressed level of consciousness 16.69 10.38 819 662213 55614 55573421
Hyperchromic anaemia 16.65 10.38 9 663023 38 55628997
Dysuria 16.62 10.38 477 662555 30252 55598783
Abdominal pain 16.59 10.38 3371 659661 255434 55373601
No adverse event 16.56 10.38 315 662717 36059 55592976
Lymph node calcification 16.55 10.38 19 663013 280 55628755
Eyelid oedema 16.53 10.38 182 662850 9586 55619449
Injection site reaction 16.49 10.38 489 662543 52758 55576277
Mitral valve incompetence 16.45 10.38 303 662729 17850 55611185
Abnormal weight gain 16.36 10.38 47 662985 1468 55627567
Blood test abnormal 16.35 10.38 226 662806 12558 55616477
Peripheral coldness 16.33 10.38 200 662832 10811 55618224
Erythema dyschromicum perstans 16.32 10.38 10 663022 56 55628979
Labile hypertension 16.31 10.38 24 663008 457 55628578
Drug dependence 16.30 10.38 178 662854 22355 55606680
Tension 16.28 10.38 73 662959 2851 55626184
Hypocalcaemia 16.27 10.38 449 662583 28311 55600724
Bladder disorder 16.19 10.38 155 662877 7869 55621166
Visual field defect 16.17 10.38 125 662907 5964 55623071
Cerebellar haematoma 16.16 10.38 21 663011 354 55628681
Seronegative arthritis 16.14 10.38 6 663026 2730 55626305
Spondylolisthesis 16.14 10.38 80 662952 3259 55625776
Pharyngitis 16.13 10.38 140 662892 18398 55610637
Premature delivery 16.09 10.38 223 662809 26837 55602198
Diabetic ketoacidosis 16.08 10.38 312 662720 18559 55610476
Throat clearing 16.08 10.38 47 662985 1483 55627552
Skin exfoliation 16.07 10.38 558 662474 36342 55592693
Aortic intramural haematoma 16.05 10.38 10 663022 58 55628977
Thyroid atrophy 16.03 10.38 7 663025 16 55629019
Anxiety disorder 16.03 10.38 88 662944 3732 55625303
Eructation 16.03 10.38 148 662884 7440 55621595
Retrograde amnesia 16.02 10.38 23 663009 428 55628607
Blood iron abnormal 15.97 10.38 10 663022 3367 55625668
Traumatic ulcer 15.96 10.38 9 663023 42 55628993
Thyroid cancer metastatic 15.91 10.38 13 663019 122 55628913
Faeces discoloured 15.87 10.38 285 662747 16711 55612324
Poor quality product administered 15.86 10.38 72 662960 2827 55626208
Atrioventricular block first degree 15.86 10.38 135 662897 6630 55622405
Aplastic anaemia 15.85 10.38 53 662979 8875 55620160
Mood altered 15.85 10.38 233 662799 13122 55615913
Breast cancer female 15.84 10.38 83 662949 12255 55616780
Thirst 15.83 10.38 200 662832 10890 55618145
Lymphoproliferative disorder 15.71 10.38 8 663024 3020 55626015
Insulin autoimmune syndrome 15.69 10.38 11 663021 80 55628955
Hormone level abnormal 15.68 10.38 61 662971 2234 55626801
Device use error 15.66 10.38 25 663007 5431 55623604
Rib deformity 15.66 10.38 16 663016 205 55628830
Thyroglobulin increased 15.64 10.38 9 663023 44 55628991
Musculoskeletal disorder 15.61 10.38 147 662885 19000 55610035
Pituitary tumour 15.61 10.38 33 662999 846 55628189
Blood triglycerides increased 15.58 10.38 208 662824 11469 55617566
Wrist fracture 15.55 10.38 213 662819 11813 55617222
Cholelithiasis 15.53 10.38 590 662442 38874 55590161
Gingival disorder 15.50 10.38 79 662953 3254 55625781
Visual acuity reduced 15.46 10.38 336 662696 20390 55608645
Drug eruption 15.43 10.38 212 662820 25551 55603484
Psoriasis 15.39 10.38 1280 661752 91412 55537623
Gastrointestinal tract irritation 15.37 10.38 23 663009 445 55628590
Sensation of foreign body 15.36 10.38 92 662940 4030 55625005
Pleural fibrosis 15.34 10.38 11 663021 3448 55625587
Labyrinthitis 15.34 10.38 60 662972 2203 55626832
Frontotemporal dementia 15.26 10.38 20 663012 340 55628695
Limb deformity 15.26 10.38 14 663018 3881 55625154
Piloerection 15.22 10.38 20 663012 341 55628694
Magnetic resonance imaging thoracic abnormal 15.21 10.38 7 663025 19 55629016
Hair growth abnormal 15.19 10.38 68 662964 2654 55626381
Endocrine disorder 15.17 10.38 27 663005 607 55628428
Dystonia 15.15 10.38 85 662947 12336 55616699
Haemoglobin decreased 15.09 10.38 1803 661229 132334 55496701
Skin toxicity 15.04 10.38 16 663016 4137 55624898
Orthostatic intolerance 15.03 10.38 37 662995 1052 55627983
Multiple drug therapy 15.02 10.38 69 662963 2723 55626312
Loss of consciousness 14.96 10.38 1489 661543 107860 55521175
Graft versus host disease in gastrointestinal tract 14.90 10.38 8 663024 2931 55626104
Aspergillus infection 14.90 10.38 42 662990 7423 55621612
Transcription medication error 14.87 10.38 15 663017 189 55628846
Rhabdomyolysis 14.86 10.38 603 662429 40055 55588980
Hepatitis B reactivation 14.84 10.38 5 663027 2419 55626616
Rectourethral fistula 14.76 10.38 8 663024 34 55629001
Bone formation increased 14.75 10.38 14 663018 163 55628872
Gingival pain 14.73 10.38 127 662905 6261 55622774
Urine odour abnormal 14.72 10.38 119 662913 5755 55623280
Nocturia 14.71 10.38 138 662894 6968 55622067
Nasal obstruction 14.68 10.38 40 662992 1211 55627824
Oesophagitis 14.67 10.38 240 662792 13817 55615218
Increased tendency to bruise 14.67 10.38 178 662854 9600 55619435
Metastatic renal cell carcinoma 14.64 10.38 35 662997 976 55628059
Lupus nephritis 14.64 10.38 7 663025 2740 55626295
Body height below normal 14.61 10.38 3 663029 2020 55627015
Neonatal tachypnoea 14.61 10.38 9 663023 51 55628984
Neck injury 14.59 10.38 51 662981 1772 55627263
Arteriosclerosis 14.58 10.38 173 662859 9280 55619755
Posterior reversible encephalopathy syndrome 14.58 10.38 119 662913 15841 55613194
Body height increased 14.47 10.38 9 663023 52 55628983
Increased appetite 14.43 10.38 162 662870 8573 55620462
Mean cell haemoglobin concentration increased 14.43 10.38 23 663009 471 55628564
Gout 14.42 10.38 213 662819 12008 55617027
Adenoiditis 14.41 10.38 8 663024 36 55628999
Coombs positive haemolytic anaemia 14.41 10.38 19 663013 325 55628710
Basedow's disease 14.37 10.38 18 663014 292 55628743
Therapeutic response changed 14.37 10.38 32 663000 851 55628184
Diffuse large B-cell lymphoma 14.35 10.38 39 662993 6977 55622058
Anti-thyroid antibody positive 14.35 10.38 21 663011 398 55628637
Carotid artery stenosis 14.28 10.38 103 662929 4807 55624228
Temperature regulation disorder 14.27 10.38 19 663013 4449 55624586
Tuberculosis 14.26 10.38 74 662958 10955 55618080
Status epilepticus 14.24 10.38 112 662920 15029 55614006
Sputum culture positive 14.22 10.38 49 662983 1690 55627345
Nephropathy toxic 14.21 10.38 52 662980 8475 55620560
Amniotic fluid volume increased 14.20 10.38 13 663019 144 55628891
Petechiae 14.13 10.38 224 662808 12815 55616220
Open reduction of fracture 14.12 10.38 37 662995 1094 55627941
Dysarthria 14.10 10.38 585 662447 38965 55590070
Acute myocardial infarction 14.10 10.38 463 662569 29930 55599105
Injection site mass 14.09 10.38 277 662755 16516 55612519
Rectal polyp 14.08 10.38 37 662995 1096 55627939
Adjustment disorder with depressed mood 14.07 10.38 24 663008 5079 55623956
Upper limb fracture 14.07 10.38 282 662750 16873 55612162
Lipoma 14.06 10.38 58 662974 2183 55626852
Injection site swelling 14.05 10.38 398 662634 43180 55585855
Groin pain 14.00 10.38 170 662862 9170 55619865
Facet joint syndrome 14.00 10.38 37 662995 6680 55622355
Myositis 13.97 10.38 157 662875 8311 55620724
Tri-iodothyronine free decreased 13.96 10.38 18 663014 301 55628734
Cystic fibrosis 13.95 10.38 12 663020 3432 55625603
Retinal artery embolism 13.95 10.38 9 663023 56 55628979
Cerebral haemorrhage 13.84 10.38 438 662594 28168 55600867
Optic nerve compression 13.81 10.38 4 663028 0 55629035
Blood pressure inadequately controlled 13.80 10.38 96 662936 4428 55624607
Granulocytopenia 13.80 10.38 109 662923 5235 55623800
Atrial septal defect 13.79 10.38 127 662905 6379 55622656
Deafness transitory 13.78 10.38 3 663029 1939 55627096
Anaemia vitamin B12 deficiency 13.78 10.38 19 663013 340 55628695
Expired product administered 13.78 10.38 113 662919 5489 55623546
Idiosyncratic drug reaction 13.76 10.38 28 663004 698 55628337
Vitello-intestinal duct remnant 13.76 10.38 8 663024 40 55628995
Hypotensive transfusion reaction 13.76 10.38 8 663024 40 55628995
Aphasia 13.76 10.38 462 662570 29953 55599082
Ejection fraction abnormal 13.75 10.38 36 662996 1064 55627971
Carcinoid tumour of the stomach 13.72 10.38 13 663019 151 55628884
Hypogammaglobulinaemia 13.70 10.38 35 662997 6391 55622644
Hyperadrenalism 13.66 10.38 6 663026 14 55629021
Intervertebral disc degeneration 13.65 10.38 240 662792 14014 55615021
Lupus vulgaris 13.65 10.38 3 663029 1926 55627109
Restlessness 13.64 10.38 410 662622 26176 55602859
Lymphocyte count decreased 13.64 10.38 239 662793 27700 55601335
Acute hepatic failure 13.64 10.38 127 662905 16451 55612584
Hypoglycaemic unconsciousness 13.60 10.38 28 663004 704 55628331
Anaemia folate deficiency 13.60 10.38 14 663018 181 55628854
Ophthalmic vein thrombosis 13.60 10.38 15 663017 211 55628824
Intramedullary rod insertion 13.60 10.38 54 662978 1997 55627038
Breast discomfort 13.57 10.38 21 663011 419 55628616
Oesophageal achalasia 13.57 10.38 21 663011 419 55628616
Abdominal pain upper 13.56 10.38 2343 660689 175970 55453065
Malignant melanoma 13.51 10.38 189 662843 10530 55618505
Sepsis 13.50 10.38 1441 661591 138399 55490636
Jaundice 13.50 10.38 419 662613 26875 55602160
Pneumonia aspiration 13.46 10.38 285 662747 32126 55596909
Electrocardiogram abnormal 13.44 10.38 151 662881 7993 55621042
Sleep disorder due to a general medical condition 13.43 10.38 165 662867 8925 55620110
Injury 13.42 10.38 572 662460 59279 55569756
Mucormycosis 13.42 10.38 8 663024 2766 55626269
Cold sweat 13.41 10.38 192 662840 10751 55618284
Recalled product administered 13.41 10.38 22 663010 462 55628573
Retching 13.39 10.38 229 662803 13301 55615734
Urine sodium decreased 13.39 10.38 13 663019 156 55628879
Poisoning 13.39 10.38 92 662940 12721 55616314
Coordination abnormal 13.37 10.38 216 662816 12405 55616630
Oesophageal disorder 13.34 10.38 56 662976 2124 55626911
BK virus infection 13.26 10.38 10 663022 3054 55625981
Impatience 13.26 10.38 19 663013 353 55628682
Spinal osteoarthritis 13.23 10.38 247 662785 14589 55614446
Decreased bronchial secretion 13.22 10.38 9 663023 62 55628973
Anal prolapse 13.21 10.38 10 663022 83 55628952
Oesophageal obstruction 13.18 10.38 22 663010 469 55628566
Product coating issue 13.17 10.38 8 663024 44 55628991
Tooth discolouration 13.12 10.38 31 663001 858 55628177
Blood pressure orthostatic decreased 13.11 10.38 9 663023 63 55628972
Lactic acidosis 13.10 10.38 525 662507 34821 55594214
Suspected suicide 13.07 10.38 28 663004 5438 55623597
Lumbar radiculopathy 13.00 10.38 50 662982 1821 55627214
Limb discomfort 12.98 10.38 408 662624 26214 55602821
Inappropriate affect 12.96 10.38 30 663002 819 55628216
Product blister packaging issue 12.94 10.38 13 663019 163 55628872
Hemiparesis 12.87 10.38 338 662694 21152 55607883
Hepatojugular reflux 12.86 10.38 6 663026 17 55629018
Primary hypothyroidism 12.84 10.38 10 663022 87 55628948
Tooth disorder 12.83 10.38 393 662639 25160 55603875
Multiple allergies 12.80 10.38 184 662848 10312 55618723
Agitation neonatal 12.79 10.38 22 663010 481 55628554
Sciatica 12.78 10.38 399 662633 25611 55603424
Irritability 12.78 10.38 447 662585 29141 55599894
Electrocardiogram change 12.73 10.38 25 663007 607 55628428
Wrong patient received product 12.70 10.38 55 662977 2116 55626919
Overgrowth bacterial 12.66 10.38 10 663022 89 55628946
Rheumatoid lung 12.65 10.38 11 663021 3129 55625906
Gastrointestinal haemorrhage 12.64 10.38 1049 661983 74902 55554133
Eye disorder 12.63 10.38 323 662709 20129 55608906
Energy increased 12.59 10.38 58 662974 2292 55626743
Arteriovenous malformation 12.56 10.38 39 662993 1273 55627762
Parathyroid gland enlargement 12.53 10.38 7 663025 32 55629003
Congenital acrochordon 12.49 10.38 8 663024 49 55628986
Melanoma recurrent 12.48 10.38 10 663022 91 55628944
Lip blister 12.44 10.38 54 662978 2079 55626956
Hypoglycaemia neonatal 12.40 10.38 31 663001 890 55628145
Thyroxine free abnormal 12.38 10.38 6 663026 19 55629016
Retinal dystrophy 12.38 10.38 6 663026 19 55629016
Oedema mouth 12.36 10.38 57 662975 2253 55626782
Hyponatraemic seizure 12.36 10.38 20 663012 415 55628620
Dental caries 12.30 10.38 178 662854 9990 55619045
Vaccination site reaction 12.30 10.38 11 663021 118 55628917
Pancreatic neoplasm 12.29 10.38 27 663005 711 55628324
Tricuspid valve incompetence 12.29 10.38 222 662810 13031 55616004
Drug withdrawal syndrome 12.28 10.38 395 662637 25462 55603573
Varicose vein 12.27 10.38 95 662937 4534 55624501
Metastases to bone 12.24 10.38 159 662873 19349 55609686
Sodium retention 12.22 10.38 11 663021 119 55628916
Lung lobectomy 12.22 10.38 10 663022 94 55628941
Acute respiratory distress syndrome 12.22 10.38 183 662849 21743 55607292
Alanine aminotransferase abnormal 12.17 10.38 20 663012 4295 55624740
Lymph node palpable 12.14 10.38 10 663022 95 55628940
Low density lipoprotein increased 12.12 10.38 114 662918 5760 55623275
Vocal cord paresis 12.08 10.38 11 663021 121 55628914
Mitral valve sclerosis 12.08 10.38 11 663021 121 55628914
Intervertebral disc disorder 12.06 10.38 93 662939 4433 55624602
Trance 12.04 10.38 7 663025 35 55629000
Acetabulum fracture 12.04 10.38 16 663016 276 55628759
Acute lymphocytic leukaemia recurrent 12.02 10.38 6 663026 2291 55626744
Immune reconstitution inflammatory syndrome 12.02 10.38 31 663001 5643 55623392
Bruxism 12.01 10.38 71 662961 3095 55625940
Vein discolouration 12.00 10.38 14 663018 210 55628825
Blindness 12.00 10.38 293 662739 18128 55610907
Barrett's oesophagus 11.99 10.38 24 663008 591 55628444
Bradykinesia 11.99 10.38 98 662934 4756 55624279
Tonsillar disorder 11.95 10.38 34 662998 1056 55627979
Large intestine polyp 11.95 10.38 140 662892 7487 55621548
Immunodeficiency 11.94 10.38 127 662905 16030 55613005
Foetal chromosome abnormality 11.94 10.38 6 663026 21 55629014
Pancreatic disorder 11.88 10.38 56 662976 2234 55626801
Drug reaction with eosinophilia and systemic symptoms 11.86 10.38 269 662763 30035 55599000
Cough 11.80 10.38 3334 659698 256627 55372408
Pulse abnormal 11.78 10.38 50 662982 1906 55627129
Emotional disorder 11.77 10.38 207 662825 12088 55616947
Electrocardiogram ST segment abnormal 11.76 10.38 31 663001 920 55628115
Peripheral vascular disorder 11.76 10.38 111 662921 5614 55623421
Haemorrhagic stroke 11.72 10.38 106 662926 5297 55623738
Congenital hydronephrosis 11.72 10.38 19 663013 395 55628640
Diabetic neuropathy 11.71 10.38 80 662952 3668 55625367
Dactylitis 11.67 10.38 5 663027 2087 55626948
Polymyalgia rheumatica 11.62 10.38 69 662963 3013 55626022
Physical abuse 11.61 10.38 4 663028 3 55629032
Neurologic neglect syndrome 11.59 10.38 54 662978 2144 55626891
Acute hepatitis B 11.58 10.38 17 663015 323 55628712
Immune-mediated hepatitis 11.54 10.38 33 662999 1028 55628007
Cardiac valve sclerosis 11.54 10.38 6 663026 23 55629012
Kidney malrotation 11.54 10.38 6 663026 23 55629012
Neck pain 11.53 10.38 858 662174 60697 55568338
Diplopia 11.52 10.38 318 662714 20051 55608984
Intentional underdose 11.49 10.38 45 662987 1653 55627382
Wheelchair user 11.47 10.38 30 663002 5436 55623599
Viral mutation identified 11.47 10.38 3 663029 1711 55627324
Mental status changes 11.45 10.38 546 662486 36955 55592080
Follicular thyroid cancer 11.43 10.38 8 663024 58 55628977
Presyncope 11.43 10.38 388 662644 25194 55603841
Ulcer 11.42 10.38 191 662841 22294 55606741
Vulvovaginal discomfort 11.40 10.38 53 662979 2102 55626933
Mastication disorder 11.38 10.38 49 662983 1880 55627155
Extrasystoles 11.37 10.38 96 662936 4703 55624332
Urinary retention 11.35 10.38 421 662611 27653 55601382
Tri-iodothyronine increased 11.33 10.38 11 663021 132 55628903
Pure white cell aplasia 11.31 10.38 7 663025 40 55628995
Pancreatic enzymes increased 11.29 10.38 25 663007 662 55628373
Atrial flutter 11.29 10.38 161 662871 9008 55620027
Weight loss poor 11.27 10.38 33 662999 1042 55627993
Application site swelling 11.26 10.38 22 663010 532 55628503
Pre-existing condition improved 11.24 10.38 135 662897 7263 55621772
Drug ineffective for unapproved indication 11.24 10.38 224 662808 25469 55603566
Pulmonary valve incompetence 11.23 10.38 37 662995 1247 55627788
Supraventricular tachyarrhythmia 11.22 10.38 9 663023 82 55628953
Blood potassium decreased 11.17 10.38 560 662472 38112 55590923
Rotator cuff repair 11.14 10.38 48 662984 1842 55627193
Euglycaemic diabetic ketoacidosis 11.14 10.38 70 662962 3119 55625916
Psychomotor hyperactivity 11.14 10.38 170 662862 9650 55619385
Microcephaly 11.13 10.38 28 663004 807 55628228
Lacrimation increased 11.11 10.38 289 662743 18059 55610976
Blood magnesium increased 11.10 10.38 11 663021 2940 55626095
Injection site pruritus 11.09 10.38 393 662639 41538 55587497
Metastases to liver 11.08 10.38 183 662849 21403 55607632
Gastric pH increased 11.05 10.38 7 663025 42 55628993
Histamine intolerance 11.05 10.38 7 663025 42 55628993
Hypernatraemia 11.04 10.38 123 662909 6497 55622538
Febrile bone marrow aplasia 11.00 10.38 40 662992 6532 55622503
Meniere's disease 11.00 10.38 13 663019 198 55628837
Deep brain stimulation 10.98 10.38 6 663026 26 55629009
Panic attack 10.95 10.38 317 662715 20130 55608905
Muscle tightness 10.94 10.38 184 662848 10652 55618383
Stress fracture 10.92 10.38 131 662901 7046 55621989
Rib fracture 10.91 10.38 315 662717 19994 55609041
Respiratory disorder neonatal 10.90 10.38 30 663002 914 55628121
Shock 10.89 10.38 185 662847 21543 55607492
Complications of transplanted kidney 10.87 10.38 7 663025 2322 55626713
Onychoclasis 10.84 10.38 107 662925 5478 55623557
Growth hormone deficiency 10.82 10.38 11 663021 140 55628895
Narrow anterior chamber angle 10.79 10.38 7 663025 44 55628991
Radiotherapy 10.79 10.38 16 663016 307 55628728
Tetany 10.78 10.38 44 662988 1648 55627387
Ventricular extrasystoles 10.76 10.38 184 662848 10686 55618349
Enamel anomaly 10.76 10.38 5 663027 14 55629021
Polydipsia 10.68 10.38 70 662962 3165 55625870
Vertigo positional 10.65 10.38 60 662972 2569 55626466
Polyp 10.65 10.38 112 662920 5830 55623205
Lumbosacral radiculopathy 10.64 10.38 17 663015 349 55628686
Stasis dermatitis 10.59 10.38 24 663008 646 55628389
Retroplacental haematoma 10.58 10.38 11 663021 144 55628891
Kidney transplant rejection 10.57 10.38 21 663011 4192 55624843
Product size issue 10.56 10.38 16 663016 313 55628722
Joint stiffness 10.56 10.38 327 662705 35098 55593937
Upper-airway cough syndrome 10.55 10.38 163 662869 9275 55619760
Deformity 10.53 10.38 74 662958 10181 55618854
Colorectal cancer 10.53 10.38 15 663017 3414 55625621
Muscle contractions involuntary 10.53 10.38 50 662982 2001 55627034
Chronic fatigue syndrome 10.51 10.38 32 663000 1033 55628002
Oral neoplasm 10.51 10.38 8 663024 67 55628968
Fracture nonunion 10.51 10.38 53 662979 2174 55626861
Renal cyst 10.50 10.38 161 662871 9148 55619887
Renal failure 10.48 10.38 1470 661562 109030 55520005
Ocular discomfort 10.48 10.38 78 662954 3677 55625358
IVth nerve paralysis 10.48 10.38 6 663026 29 55629006
Senile osteoporosis 10.46 10.38 13 663019 209 55628826
Phobia 10.45 10.38 16 663016 316 55628719
Pleural neoplasm 10.43 10.38 17 663015 355 55628680
Malignant neoplasm progression 10.41 10.38 736 662296 72851 55556184
Throat lesion 10.41 10.38 11 663021 147 55628888
Hallucination 10.40 10.38 692 662340 48457 55580578
Acute myeloid leukaemia 10.40 10.38 139 662893 16833 55612202
Mental impairment 10.39 10.38 209 662823 12513 55616522

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypothyroidism 652.93 10.54 649 180110 17298 31499287
Blood thyroid stimulating hormone increased 302.28 10.54 210 180549 3327 31513258
Drug abuse 265.24 10.54 85 180674 87673 31428912
Foetal exposure during pregnancy 208.38 10.54 608 180151 40268 31476317
Drug ineffective 198.30 10.54 1383 179376 394190 31122395
Toxicity to various agents 180.91 10.54 488 180271 180999 31335586
Atrial septal defect 172.14 10.54 205 180554 6722 31509863
Off label use 159.02 10.54 1245 179514 346029 31170556
Febrile neutropenia 126.35 10.54 321 180438 121528 31395057
Craniopharyngioma 124.35 10.54 51 180708 246 31516339
Fatigue 108.00 10.54 2585 178174 332621 31183964
Small for dates baby 105.71 10.54 117 180642 3538 31513047
Blood thyroid stimulating hormone decreased 101.61 10.54 85 180674 1798 31514787
Thyroid disorder 99.52 10.54 103 180656 2880 31513705
Asthenia 88.32 10.54 1784 178975 222971 31293614
Treatment failure 83.56 10.54 66 180693 40726 31475859
Thyroid function test abnormal 82.79 10.54 51 180708 651 31515934
Blood thyroid stimulating hormone abnormal 72.93 10.54 37 180722 314 31516271
Pituitary tumour benign 72.56 10.54 50 180709 781 31515804
Neutropenia 67.32 10.54 496 180263 139868 31376717
Drug resistance 66.85 10.54 25 180734 23428 31493157
Drug dependence 62.81 10.54 25 180734 22554 31494031
Insulin-like growth factor decreased 57.58 10.54 29 180730 242 31516343
Thyroxine free decreased 56.29 10.54 29 180730 255 31516330
Large for dates baby 56.11 10.54 44 180715 846 31515739
Respiratory disorder neonatal 56.07 10.54 55 180704 1440 31515145
Product use in unapproved indication 52.68 10.54 340 180419 98831 31417754
Hypopituitarism 52.67 10.54 61 180698 1940 31514645
Insulin-like growth factor increased 50.92 10.54 47 180712 1138 31515447
Thyroid cancer 50.42 10.54 54 180705 1572 31515013
Patent ductus arteriosus 49.39 10.54 75 180684 3118 31513467
Autoimmune thyroiditis 47.82 10.54 44 180715 1061 31515524
Hyperthyroidism 46.88 10.54 141 180618 9490 31507095
Chronic pigmented purpura 45.46 10.54 19 180740 97 31516488
Infantile apnoea 43.98 10.54 39 180720 895 31515690
Decreased appetite 43.85 10.54 1164 179595 152053 31364532
Adrenocortical insufficiency acute 43.76 10.54 46 180713 1310 31515275
Bradycardia neonatal 43.40 10.54 39 180720 911 31515674
Dizziness 42.23 10.54 1458 179301 197689 31318896
Thyroxine decreased 42.02 10.54 19 180740 121 31516464
Fall 41.38 10.54 1370 179389 184719 31331866
Cytomegalovirus infection 40.17 10.54 49 180710 24658 31491927
Pyloric stenosis 40.06 10.54 34 180725 734 31515851
Neurotoxicity 38.94 10.54 22 180737 16204 31500381
Ventricular septal defect 36.57 10.54 71 180688 3606 31512979
Bone marrow failure 36.31 10.54 65 180694 27943 31488642
Rheumatoid arthritis 36.13 10.54 145 180614 47664 31468921
Intentional product misuse 35.51 10.54 105 180654 37846 31478739
Goitre 35.26 10.54 44 180715 1515 31515070
Suicide attempt 34.89 10.54 103 180656 37145 31479440
Thyroid hormones decreased 34.25 10.54 17 180742 137 31516448
Epiphysiolysis 33.91 10.54 15 180744 90 31516495
Tropical infectious disease 33.64 10.54 12 180747 36 31516549
Pituitary tumour recurrent 33.05 10.54 13 180746 55 31516530
Sepsis 32.40 10.54 641 180118 151288 31365297
Multiple organ dysfunction syndrome 32.17 10.54 242 180517 67961 31448624
Hypophysitis 31.98 10.54 49 180710 2053 31514532
Graft versus host disease 31.74 10.54 10 180749 10437 31506148
Secondary hypogonadism 31.32 10.54 20 180739 273 31516312
Immune reconstitution inflammatory syndrome 30.48 10.54 5 180754 8173 31508412
Synovitis 30.43 10.54 16 180743 12267 31504318
Diarrhoea 29.90 10.54 2364 178395 350045 31166540
Pneumocystis jirovecii pneumonia 29.87 10.54 36 180723 18215 31498370
Adrenal insufficiency 29.74 10.54 147 180612 12512 31504073
Dysphonia 29.53 10.54 210 180549 20381 31496204
Toxic epidermal necrolysis 29.39 10.54 41 180718 19483 31497102
Overdose 29.25 10.54 325 180434 84339 31432246
Infusion related reaction 28.52 10.54 159 180600 47896 31468689
Blood testosterone decreased 28.24 10.54 70 180689 4203 31512382
Drug hypersensitivity 28.22 10.54 271 180488 72328 31444257
Bronchopulmonary aspergillosis 27.99 10.54 22 180737 13612 31502973
Therapeutic product effect incomplete 27.93 10.54 141 180618 43555 31473030
Dehydration 27.75 10.54 882 179877 118229 31398356
Potassium wasting nephropathy 27.61 10.54 13 180746 92 31516493
Substance abuse 27.53 10.54 4 180755 7154 31509431
Pyrexia 27.43 10.54 1435 179324 302405 31214180
Haematotoxicity 27.42 10.54 4 180755 7133 31509452
Leukopenia 27.36 10.54 205 180554 57623 31458962
Neonatal behavioural syndrome 27.28 10.54 14 180745 122 31516463
Pathogen resistance 27.02 10.54 8 180751 8693 31507892
Macrocephaly 26.59 10.54 22 180737 458 31516127
Palmar-plantar erythrodysaesthesia syndrome 26.48 10.54 165 180594 15318 31501267
Diabetes insipidus 26.44 10.54 50 180709 2490 31514095
Drug ineffective for unapproved indication 26.15 10.54 38 180721 17752 31498833
Thyroxine free increased 26.13 10.54 17 180742 240 31516345
Walking aid user 26.12 10.54 39 180720 1597 31514988
Diabetic foetopathy 26.06 10.54 16 180743 203 31516382
Hypospadias 26.05 10.54 56 180703 3060 31513525
Aspergillus infection 25.75 10.54 17 180742 11511 31505074
Cytomegalovirus viraemia 25.31 10.54 4 180755 6721 31509864
Flatulence 25.31 10.54 190 180569 18758 31497827
Poisoning 25.06 10.54 14 180745 10377 31506208
Blood thyroid stimulating hormone normal 25.04 10.54 6 180753 0 31516585
Neoplasm recurrence 25.02 10.54 44 180715 2070 31514515
Papillary thyroid cancer 24.98 10.54 24 180735 612 31515973
Electrocardiogram QRS complex abnormal 24.73 10.54 18 180741 308 31516277
Myxoedema coma 24.70 10.54 17 180742 265 31516320
Premature baby 24.61 10.54 182 180577 17884 31498701
General physical health deterioration 24.37 10.54 832 179927 112603 31403982
Pulmonary valve stenosis congenital 24.16 10.54 13 180746 126 31516459
Weight decreased 24.08 10.54 1129 179630 158823 31357762
Newborn persistent pulmonary hypertension 23.64 10.54 12 180747 102 31516483
Septic shock 23.63 10.54 252 180507 65906 31450679
Congenital mitral valve incompetence 23.34 10.54 12 180747 105 31516480
Anti-thyroid antibody positive 23.32 10.54 10 180749 55 31516530
Thyroiditis 23.32 10.54 43 180716 2100 31514485
Selective eating disorder 23.28 10.54 38 180721 1682 31514903
Cerebral atrophy congenital 22.89 10.54 10 180749 58 31516527
Painful respiration 22.84 10.54 31 180728 1161 31515424
C-reactive protein increased 22.76 10.54 173 180586 48477 31468108
Glossodynia 22.52 10.54 56 180703 3369 31513216
Growth hormone deficiency 22.42 10.54 16 180743 265 31516320
Tri-iodothyronine decreased 22.35 10.54 9 180750 41 31516544
Contraindicated product administered 22.11 10.54 50 180709 19722 31496863
Neutropenic sepsis 21.81 10.54 23 180736 12356 31504229
Thyroid hormones increased 21.57 10.54 10 180749 68 31516517
Granulocytopenia 21.42 10.54 80 180679 6019 31510566
Sedation 21.17 10.54 48 180711 18917 31497668
Intentional self-injury 21.02 10.54 27 180732 13288 31503297
Hypoglycaemia neonatal 20.98 10.54 37 180722 1745 31514840
Post procedural hypothyroidism 20.91 10.54 6 180753 6 31516579
Blood thyroid stimulating hormone 20.86 10.54 5 180754 0 31516585
Epstein-Barr virus infection 20.51 10.54 7 180752 6946 31509639
Aortic aneurysm 20.42 10.54 82 180677 6383 31510202
Coeliac disease 20.41 10.54 21 180738 583 31516002
Hypoacusis 20.37 10.54 151 180608 14848 31501737
Pituitary apoplexy 20.31 10.54 8 180751 34 31516551
Cerebrovascular accident 20.21 10.54 595 180164 78889 31437696
Therapy non-responder 19.99 10.54 112 180647 33699 31482886
Neonatal respiratory distress syndrome 19.98 10.54 58 180701 3827 31512758
Product use issue 19.94 10.54 217 180542 56542 31460043
Haemangioma congenital 19.92 10.54 19 180740 480 31516105
Growth retardation 19.90 10.54 35 180724 1647 31514938
Tumour lysis syndrome 19.67 10.54 36 180723 15349 31501236
Fractured coccyx 19.56 10.54 12 180747 152 31516433
Hepatic function abnormal 19.56 10.54 146 180613 41076 31475509
Transplant rejection 19.51 10.54 16 180743 9692 31506893
Drug intolerance 19.47 10.54 196 180563 51837 31464748
Dermatomyositis 19.45 10.54 29 180730 1186 31515399
Completed suicide 19.21 10.54 387 180372 91127 31425458
Dry skin 19.15 10.54 226 180533 25255 31491330
Thyroid cancer metastatic 19.12 10.54 8 180751 41 31516544
Ankylosing spondylitis 19.02 10.54 5 180754 5876 31510709
Neonatal tachypnoea 18.97 10.54 12 180747 161 31516424
Anencephaly 18.73 10.54 11 180748 128 31516457
Respiratory depression 18.51 10.54 34 180725 14476 31502109
Wrong schedule 18.47 10.54 12 180747 169 31516416
Hyponatraemia 18.37 10.54 551 180208 73248 31443337
Infective pulmonary exacerbation of cystic fibrosis 18.33 10.54 7 180752 6477 31510108
Febrile bone marrow aplasia 18.31 10.54 11 180748 7835 31508750
Pituitary tumour 18.22 10.54 19 180740 536 31516049
Myelosuppression 18.13 10.54 36 180723 14884 31501701
Haemophagocytic lymphohistiocytosis 18.11 10.54 24 180735 11654 31504931
Intentional overdose 18.05 10.54 150 180609 41239 31475346
Drug reaction with eosinophilia and systemic symptoms 17.98 10.54 99 180660 29919 31486666
Cortisol decreased 17.95 10.54 25 180734 960 31515625
Conduction disorder 17.88 10.54 36 180723 1878 31514707
Rhythm idioventricular 17.73 10.54 14 180745 272 31516313
Blood growth hormone increased 17.71 10.54 15 180744 323 31516262
Neutrophil count decreased 17.68 10.54 174 180585 46220 31470365
Alanine aminotransferase increased 17.11 10.54 311 180448 74345 31442240
Neonatal respiratory acidosis 16.95 10.54 8 180751 57 31516528
Dependence on oxygen therapy 16.75 10.54 12 180747 200 31516385
Thyroid cancer recurrent 16.69 10.54 4 180755 0 31516585
Interstitial lung disease 16.64 10.54 248 180511 61155 31455430
Metastatic renal cell carcinoma 16.49 10.54 41 180718 2466 31514119
Tri-iodothyronine increased 16.38 10.54 8 180751 62 31516523
Anaphylactic reaction 16.35 10.54 100 180659 29453 31487132
Tachyarrhythmia 16.31 10.54 48 180711 3191 31513394
Intercapillary glomerulosclerosis 16.25 10.54 7 180752 39 31516546
Brain natriuretic peptide abnormal 16.24 10.54 14 180745 309 31516276
Pseudomonas infection 16.13 10.54 25 180734 11376 31505209
Alveolitis 16.11 10.54 31 180728 1564 31515021
Total lung capacity abnormal 16.08 10.54 10 180749 130 31516455
Acute graft versus host disease in skin 15.84 10.54 4 180755 4828 31511757
Colorectal cancer 15.82 10.54 4 180755 4825 31511760
Mucormycosis 15.77 10.54 6 180753 5564 31511021
Cytopenia 15.71 10.54 24 180735 10986 31505599
Anaphylactic shock 15.63 10.54 36 180723 14109 31502476
Constipation 15.52 10.54 860 179899 123131 31393454
Coagulation disorder neonatal 15.52 10.54 6 180753 24 31516561
Adenovirus infection 15.46 10.54 4 180755 4750 31511835
C-reactive protein abnormal 15.37 10.54 13 180746 7756 31508829
Mucosal inflammation 15.36 10.54 124 180635 34303 31482282
Pulmonary artery stenosis 15.25 10.54 12 180747 232 31516353
Enthesopathy 15.16 10.54 3 180756 4284 31512301
Neonatal respiratory distress 15.15 10.54 17 180742 522 31516063
Urine oxalate increased 15.11 10.54 5 180754 11 31516574
Delirium 15.10 10.54 157 180602 41264 31475321
Hyperprolactinaemia 15.08 10.54 29 180730 1462 31515123
Exposure via breast milk 15.06 10.54 33 180726 1827 31514758
Nephropathy toxic 15.03 10.54 26 180733 11327 31505258
Tongue movement disturbance 15.00 10.54 8 180751 76 31516509
Foreign body in throat 15.00 10.54 8 180751 76 31516509
N-terminal prohormone brain natriuretic peptide abnormal 14.88 10.54 11 180748 193 31516392
Diffuse alopecia 14.81 10.54 5 180754 12 31516573
Sopor 14.80 10.54 27 180732 11525 31505060
Pulmonary arterial pressure abnormal 14.78 10.54 11 180748 195 31516390
Colitis ulcerative 14.76 10.54 55 180704 18474 31498111
Thyroidectomy 14.70 10.54 7 180752 51 31516534
Product prescribing error 14.66 10.54 174 180585 19468 31497117
Blood glucose increased 14.65 10.54 454 180305 60629 31455956
Bronchiectasis 14.61 10.54 13 180746 7567 31509018
Atrial fibrillation 14.60 10.54 791 179968 112992 31403593
Epispadias 14.58 10.54 10 180749 155 31516430
Hypersomnia 14.57 10.54 111 180648 11008 31505577
Thyroxine increased 14.49 10.54 8 180751 82 31516503
Hepatotoxicity 14.45 10.54 58 180701 19068 31497517
Forced vital capacity decreased 14.34 10.54 19 180740 695 31515890
Shoulder dystocia 14.30 10.54 6 180753 31 31516554
Therapy partial responder 14.23 10.54 10 180749 6552 31510033
Anaemia of malignant disease 14.02 10.54 15 180744 436 31516149
Prescribed underdose 14.02 10.54 88 180671 8190 31508395
Chest injury 13.99 10.54 28 180731 1454 31515131
Tracheal fistula 13.93 10.54 8 180751 89 31516496
Muscular weakness 13.78 10.54 479 180280 64969 31451616
BK virus infection 13.59 10.54 6 180753 5089 31511496
Condition aggravated 13.56 10.54 781 179978 163228 31353357
Aorticopulmonary septal defect 13.55 10.54 5 180754 17 31516568
Lymphocyte count decreased 13.55 10.54 66 180693 20583 31496002
Serotonin syndrome 13.51 10.54 58 180701 18715 31497870
Lumbar puncture 13.48 10.54 8 180751 95 31516490
Mineral deficiency 13.43 10.54 6 180753 37 31516548
Urticaria 13.37 10.54 239 180520 57278 31459307
Osteochondroma 13.34 10.54 5 180754 18 31516567
Oxygen saturation increased 13.30 10.54 12 180747 282 31516303
Ageusia 13.28 10.54 95 180664 9236 31507349
Drug interaction 13.21 10.54 1017 179742 207526 31309059
Aplastic anaemia 13.19 10.54 20 180739 9183 31507402
Maternal exposure during breast feeding 13.14 10.54 28 180731 1521 31515064
Brain oedema 13.12 10.54 34 180725 12798 31503787
Medulloblastoma recurrent 13.08 10.54 7 180752 67 31516518
Appendicitis 12.81 10.54 29 180730 11436 31505149
Follicular thyroid cancer 12.68 10.54 4 180755 7 31516578
Hypotonia neonatal 12.68 10.54 25 180734 1284 31515301
Acute myeloid leukaemia 12.65 10.54 59 180700 18613 31497972
Tricuspid valve incompetence 12.63 10.54 90 180669 8739 31507846
Tracheal pain 12.57 10.54 6 180753 44 31516541
Empty sella syndrome 12.57 10.54 6 180753 44 31516541
Polyglandular autoimmune syndrome type II 12.52 10.54 3 180756 0 31516585
Primary hypothyroidism 12.45 10.54 6 180753 45 31516540
Blood glucose decreased 12.37 10.54 117 180642 12354 31504231
Thyroid operation 12.34 10.54 4 180755 8 31516577
Neonatal pneumothorax 12.34 10.54 4 180755 8 31516577
Neutrophil count increased 12.33 10.54 47 180712 15684 31500901
Cardiogenic shock 12.30 10.54 76 180683 22332 31494253
Product substitution issue 12.27 10.54 94 180665 9338 31507247
Oedema peripheral 12.25 10.54 754 180005 109085 31407500
Cytokine release syndrome 12.24 10.54 51 180708 16591 31499994
Chest discomfort 12.16 10.54 203 180556 49166 31467419
Application site erythema 12.14 10.54 33 180726 2096 31514489
Hypernatraemia 12.08 10.54 80 180679 7583 31509002
Retrograde amnesia 12.06 10.54 8 180751 117 31516468
Seroma 12.00 10.54 16 180743 589 31515996
Disorientation 11.99 10.54 244 180515 30500 31486085
Cranial sutures widening 11.95 10.54 7 180752 81 31516504
Hypertension 11.90 10.54 866 179893 127234 31389351
Intentional product use issue 11.80 10.54 204 180555 49143 31467442
Cardiotoxicity 11.80 10.54 7 180752 5020 31511565
Tri-iodothyronine free increased 11.74 10.54 4 180755 10 31516575
Urethral valves 11.73 10.54 11 180748 272 31516313
Pancytopenia 11.72 10.54 394 180365 86922 31429663
Hypersensitivity 11.61 10.54 236 180523 55507 31461078
Neonatal asphyxia 11.58 10.54 12 180747 336 31516249
Cytomegalovirus infection reactivation 11.52 10.54 4 180755 3925 31512660
Myoclonic dystonia 11.47 10.54 4 180755 11 31516574
Thyroxine abnormal 11.47 10.54 4 180755 11 31516574
Therapeutic product effect decreased 11.46 10.54 120 180639 31502 31485083
Liposarcoma 11.45 10.54 8 180751 128 31516457
Extrapyramidal disorder 11.44 10.54 32 180727 11746 31504839
Bradycardia 11.42 10.54 494 180265 68833 31447752
Infection 11.40 10.54 368 180391 81563 31435022
Neonatal respiratory failure 11.35 10.54 12 180747 344 31516241
Syncope 11.28 10.54 594 180165 84588 31431997
Congenital hydronephrosis 11.28 10.54 17 180742 702 31515883
Skin indentation 11.21 10.54 4 180755 12 31516573
Thrombocytopenia 11.21 10.54 683 180076 142064 31374521
Gastrooesophageal cancer 11.17 10.54 5 180754 31 31516554
Growth hormone-producing pituitary tumour 10.91 10.54 6 180753 61 31516524
Toxic neuropathy 10.89 10.54 14 180745 497 31516088
Agitation neonatal 10.88 10.54 21 180738 1062 31515523
Hyperbilirubinaemia neonatal 10.87 10.54 17 180742 725 31515860
Thyroid mass 10.82 10.54 13 180746 430 31516155
Artery dissection 10.81 10.54 7 180752 98 31516487
Blood prolactin decreased 10.80 10.54 10 180749 243 31516342
Hyperparathyroidism 10.79 10.54 22 180737 1158 31515427
Scapula fracture 10.77 10.54 10 180749 244 31516341
Performance enhancing product use 10.75 10.54 7 180752 99 31516486
Haemorrhoids 10.75 10.54 113 180646 12269 31504316
Gait inability 10.73 10.54 161 180598 18983 31497602
Gangrene neonatal 10.69 10.54 9 180750 192 31516393
Brachydactyly 10.69 10.54 9 180750 192 31516393
Oral discomfort 10.69 10.54 35 180724 2465 31514120
Application site inflammation 10.69 10.54 7 180752 100 31516485
Bronchopneumopathy 10.66 10.54 13 180746 437 31516148
Moaning 10.62 10.54 17 180742 740 31515845
Cholelithiasis 10.60 10.54 163 180596 19316 31497269
Cervicogenic headache 10.54 10.54 4 180755 15 31516570
Incarcerated umbilical hernia 10.54 10.54 4 180755 15 31516570
Hospice care 10.54 10.54 61 180698 5515 31511070

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypothyroidism 1339.60 10.29 1898 670200 43857 70212489
Blood thyroid stimulating hormone increased 787.42 10.29 649 671449 7830 70248516
Drug ineffective 628.02 10.29 5794 666304 933958 69322388
Pemphigus 531.24 10.29 77 672021 82959 70173387
Off label use 455.29 10.29 4676 667422 738384 69517962
Drug abuse 448.22 10.29 440 671658 146816 70109530
Synovitis 438.02 10.29 349 671749 128879 70127467
Rheumatoid arthritis 437.96 10.29 1365 670733 290440 69965906
Anti-cyclic citrullinated peptide antibody positive 431.03 10.29 73 672025 70112 70186234
Toxicity to various agents 429.98 10.29 2010 670088 380162 69876184
Treatment failure 399.34 10.29 466 671632 143676 70112670
Contraindicated product administered 387.30 10.29 422 671676 134190 70122156
Systemic lupus erythematosus 384.97 10.29 245 671853 101657 70154689
Hand deformity 362.43 10.29 183 671915 86299 70170047
Drug intolerance 351.88 10.29 1037 671061 224650 70031696
Fall 350.14 10.29 6031 666067 438065 69818281
Infusion related reaction 344.49 10.29 859 671239 196675 70059671
Pericarditis 342.05 10.29 188 671910 84517 70171829
Febrile neutropenia 333.81 10.29 918 671180 203400 70052946
Glossodynia 322.50 10.29 211 671887 86276 70170070
Duodenal ulcer perforation 279.05 10.29 70 672028 51042 70205304
Blood thyroid stimulating hormone decreased 277.58 10.29 299 671799 5155 70251191
Rheumatoid factor positive 246.12 10.29 76 672022 48324 70208022
Hyperthyroidism 241.19 10.29 566 671532 19525 70236821
Completed suicide 239.79 10.29 1221 670877 225914 70030432
Arthropathy 238.49 10.29 683 671415 149374 70106972
Therapeutic product effect decreased 232.44 10.29 644 671454 142374 70113972
Blood thyroid stimulating hormone normal 229.03 10.29 73 672025 52 70256294
Folliculitis 223.49 10.29 63 672035 42507 70213839
Thyroid disorder 217.34 10.29 416 671682 12416 70243930
Asthenia 216.19 10.29 5771 666327 451895 69804451
Muscle injury 213.49 10.29 51 672047 38443 70217903
Drug resistance 212.99 10.29 50 672048 38140 70218206
Helicobacter infection 209.91 10.29 134 671964 55522 70200824
Drug hypersensitivity 209.55 10.29 1540 670558 260919 69995427
Palpitations 189.07 10.29 1739 670359 109014 70147332
Wound 186.69 10.29 411 671687 98321 70158025
Dizziness 185.00 10.29 5729 666369 458412 69797934
Sleep disorder due to general medical condition, insomnia type 181.88 10.29 56 672042 35676 70220670
Product use in unapproved indication 181.03 10.29 1186 670912 206292 70050054
Blood thyroid stimulating hormone abnormal 181.02 10.29 109 671989 758 70255588
Thyroid function test abnormal 180.81 10.29 180 671918 2817 70253529
Hepatic enzyme increased 174.79 10.29 828 671270 156162 70100184
Lower respiratory tract infection 173.70 10.29 515 671583 111398 70144948
Discomfort 155.94 10.29 496 671602 104940 70151406
Hypersensitivity 149.61 10.29 1423 670675 228389 70027957
Hyponatraemia 148.88 10.29 2236 669862 157851 70098495
Cytomegalovirus infection 148.18 10.29 97 672001 39661 70216685
Fatigue 146.88 10.29 9364 662734 814955 69441391
Joint swelling 143.52 10.29 1620 670478 251591 70004755
Balance disorder 140.82 10.29 1389 670709 88739 70167607
Headache 139.86 10.29 6780 665318 573625 69682721
Muscle spasms 136.08 10.29 2133 669965 151913 70104433
Neutropenia 135.06 10.29 1673 670425 255483 70000863
Infection 134.30 10.29 1312 670786 209473 70046873
Maternal exposure during pregnancy 133.32 10.29 600 671498 114745 70141601
Myalgia 128.90 10.29 2272 669826 165620 70090726
Pyrexia 128.20 10.29 4585 667513 602367 69653979
Multiple organ dysfunction syndrome 124.50 10.29 566 671532 107949 70148397
Craniopharyngioma 122.21 10.29 64 672034 326 70256020
Product substitution issue 118.68 10.29 416 671682 18097 70238249
Hepatic function abnormal 117.39 10.29 297 671801 67699 70188647
Intentional overdose 116.80 10.29 507 671591 97928 70158418
Irritable bowel syndrome 116.03 10.29 189 671909 50661 70205685
Transplant rejection 113.55 10.29 18 672080 18153 70238193
Nausea 111.55 10.29 9444 662654 842644 69413702
Bone marrow failure 109.19 10.29 185 671913 48825 70207521
Vertigo 108.58 10.29 987 671111 61656 70194690
Constipation 107.88 10.29 3144 668954 249294 70007052
Feeling abnormal 107.46 10.29 1921 670177 140398 70115948
Sedation complication 105.43 10.29 323 671775 13087 70243259
Creatinine renal clearance decreased 104.70 10.29 380 671718 16820 70239526
Product use issue 103.55 10.29 1147 670951 178790 70077556
Orthostatic hypotension 101.02 10.29 837 671261 50906 70205440
Myelosuppression 98.87 10.29 84 672014 30061 70226285
Product prescribing error 97.44 10.29 668 671430 38284 70218062
Blood calcium decreased 97.00 10.29 534 671564 28312 70228034
Product quality issue 92.44 10.29 550 671548 30011 70226335
Swelling 91.05 10.29 1248 670850 187291 70069055
C-reactive protein abnormal 89.32 10.29 142 671956 38437 70217909
Cognitive disorder 88.75 10.29 926 671172 60030 70196316
Therapy non-responder 87.72 10.29 402 671696 76513 70179833
Septic shock 87.41 10.29 663 671435 111595 70144751
Autoimmune thyroiditis 86.33 10.29 141 671957 3701 70252645
Death 83.68 10.29 3965 668133 506096 69750250
Adrenocortical insufficiency acute 83.05 10.29 114 671984 2552 70253794
Neurotoxicity 81.92 10.29 97 672001 29729 70226617
Sepsis 81.60 10.29 1731 670367 242814 70013532
Vision blurred 81.49 10.29 1309 670789 93675 70162671
Abdominal discomfort 78.64 10.29 1496 670602 213162 70043184
Dysgeusia 78.32 10.29 765 671333 48737 70207609
Overdose 77.91 10.29 1135 670963 168610 70087736
Toxic epidermal necrolysis 77.81 10.29 161 671937 39396 70216950
Acute graft versus host disease 77.39 10.29 3 672095 9559 70246787
Venoocclusive liver disease 75.49 10.29 7 672091 10671 70245675
Sensitisation 74.42 10.29 104 671994 2369 70253977
Post transplant lymphoproliferative disorder 74.32 10.29 7 672091 10538 70245808
Diarrhoea 72.93 10.29 8481 663617 774860 69481486
Pathogen resistance 72.84 10.29 18 672080 13261 70243085
Syncope 72.70 10.29 2071 670027 163638 70092708
Product complaint 72.57 10.29 268 671830 11963 70244383
Haemophagocytic lymphohistiocytosis 71.53 10.29 49 672049 19563 70236783
Urinary tract infection 71.26 10.29 2959 669139 245810 70010536
Thyroid cancer 70.74 10.29 153 671945 4992 70251354
Cardio-respiratory arrest 70.40 10.29 612 671486 100065 70156281
Intentional product use issue 70.22 10.29 763 671335 119379 70136967
Insulin-like growth factor increased 69.69 10.29 85 672013 1686 70254660
Cardiac arrest 68.80 10.29 1082 671016 158752 70097594
Neutrophil count decreased 68.15 10.29 487 671611 83069 70173277
Gastrointestinal disorder 68.02 10.29 654 671444 104773 70151573
Impaired healing 67.94 10.29 419 671679 73955 70182391
Dehydration 67.56 10.29 2702 669396 223440 70032906
Pneumocystis jirovecii pneumonia 66.59 10.29 114 671984 29968 70226378
Dry skin 66.20 10.29 816 671282 55115 70201231
Red blood cell sedimentation rate abnormal 65.52 10.29 52 672046 19251 70237095
Hot flush 65.14 10.29 738 671360 48846 70207500
Bronchopulmonary aspergillosis 64.72 10.29 62 672036 20940 70235406
Disturbance in attention 64.52 10.29 656 671442 42238 70214108
Stomatitis 64.43 10.29 844 671254 127667 70128679
Pituitary tumour benign 64.05 10.29 97 672001 2382 70253964
Haematotoxicity 63.45 10.29 25 672073 13649 70242697
Myxoedema coma 63.26 10.29 53 672045 655 70255691
Product formulation issue 62.60 10.29 57 672041 793 70255553
Ill-defined disorder 62.48 10.29 286 671812 54455 70201891
Pain in extremity 62.30 10.29 3750 668348 324332 69932014
Drug dependence 61.37 10.29 167 671931 37154 70219192
Suicide attempt 61.22 10.29 471 671627 79039 70177307
Respiratory arrest 60.83 10.29 283 671815 53650 70202696
Cystitis haemorrhagic 59.78 10.29 6 672092 8587 70247759
Hepatotoxicity 59.51 10.29 215 671883 43771 70212575
Enthesopathy 59.10 10.29 15 672083 10854 70245492
Cytomegalovirus viraemia 58.24 10.29 19 672079 11666 70244680
Prostate cancer 57.84 10.29 131 671967 31032 70225314
Atrial fibrillation 57.71 10.29 2214 669884 182134 70074212
C-reactive protein increased 57.19 10.29 721 671377 109796 70146550
Dry mouth 57.09 10.29 962 671136 69495 70186851
Substance abuse 56.62 10.29 12 672086 9825 70246521
Aspergillus infection 55.94 10.29 52 672046 17816 70238530
Dysphonia 55.91 10.29 723 671375 49377 70206969
Transient ischaemic attack 55.55 10.29 673 671425 45271 70211075
Thyroxine free increased 54.83 10.29 62 672036 1131 70255215
Multiple-drug resistance 54.27 10.29 4 672094 7351 70248995
Blister 54.21 10.29 650 671448 99876 70156470
Graft versus host disease 54.17 10.29 38 672060 14985 70241361
Papillary thyroid cancer 54.09 10.29 89 672009 2351 70253995
Infective pulmonary exacerbation of cystic fibrosis 53.56 10.29 24 672074 12134 70244212
Respiratory failure 53.19 10.29 1205 670893 167530 70088816
Thyroid hormones decreased 52.45 10.29 37 672061 347 70255999
Thrombocytopenia 52.39 10.29 1797 670301 237313 70019033
Panniculitis 52.09 10.29 18 672080 10658 70245688
Muscular weakness 51.85 10.29 1696 670402 136640 70119706
Therapeutic response unexpected 51.28 10.29 322 671776 17909 70238437
Flatulence 50.93 10.29 570 671528 37611 70218735
Tremor 50.85 10.29 1878 670220 153746 70102600
Diffuse alopecia 50.71 10.29 45 672053 604 70255742
Musculoskeletal stiffness 50.69 10.29 1041 671057 146719 70109627
Gait disturbance 50.55 10.29 2191 669907 182915 70073431
Mucosal inflammation 50.34 10.29 406 671692 67444 70188902
Thyroidectomy 50.24 10.29 51 672047 818 70255528
Adenovirus infection 50.14 10.29 7 672091 7761 70248585
Pituitary tumour recurrent 50.03 10.29 26 672072 130 70256216
Cytokine release syndrome 49.33 10.29 111 671987 26356 70229990
Oedema peripheral 48.85 10.29 2636 669462 225455 70030891
Thyroid hormones increased 47.96 10.29 36 672062 375 70255971
Malaise 47.77 10.29 4742 667356 428190 69828156
Thyroxine free decreased 47.63 10.29 53 672045 949 70255397
Bone pain 47.24 10.29 710 671388 50112 70206234
Rheumatoid nodule 46.99 10.29 44 672054 15023 70241323
Insulin-like growth factor decreased 46.95 10.29 41 672057 538 70255808
Immune reconstitution inflammatory syndrome 46.65 10.29 33 672065 12957 70243389
Blood thyroid stimulating hormone 46.42 10.29 14 672084 6 70256340
Reaction to excipient 46.41 10.29 63 672035 1395 70254951
Oral pain 46.37 10.29 450 671648 28616 70227730
Disseminated intravascular coagulation 46.26 10.29 163 671935 33435 70222911
Polycystic ovaries 46.07 10.29 91 672007 2781 70253565
Weight decreased 45.97 10.29 3476 668622 307012 69949334
Gastrooesophageal reflux disease 45.73 10.29 1156 670942 89683 70166663
Product monitoring error 44.94 10.29 154 671944 6622 70249724
Carpal tunnel syndrome 44.74 10.29 296 671802 16761 70239585
Condition aggravated 44.70 10.29 3467 668631 424168 69832178
Dysphagia 44.01 10.29 1390 670708 111444 70144902
Chronic graft versus host disease 43.94 10.29 6 672092 6764 70249582
Anaphylactic reaction 43.46 10.29 477 671621 74497 70181849
Abdominal pain upper 43.37 10.29 2247 669851 191355 70064991
Psoriatic arthropathy 42.97 10.29 399 671699 64372 70191974
Decreased appetite 42.95 10.29 3399 668699 301381 69954965
Acute myeloid leukaemia 42.67 10.29 150 671948 30790 70225556
Pancytopenia 42.44 10.29 1098 671000 150009 70106337
Drug tolerance decreased 42.40 10.29 20 672078 9813 70246533
Hypopituitarism 42.28 10.29 91 672007 2959 70253387
Bone erosion 42.04 10.29 49 672049 15124 70241222
Tumour lysis syndrome 41.95 10.29 87 672011 21273 70235073
Colorectal cancer 41.82 10.29 14 672084 8456 70247890
Graft versus host disease in skin 41.72 10.29 3 672095 5627 70250719
Hip fracture 41.44 10.29 430 671668 27833 70228513
Ejection fraction 41.41 10.29 66 672032 1696 70254650
Drug reaction with eosinophilia and systemic symptoms 41.28 10.29 351 671747 57662 70198684
Tri-iodothyronine decreased 41.05 10.29 26 672072 200 70256146
Therapeutic product effect incomplete 40.70 10.29 846 671252 119036 70137310
Drug ineffective for unapproved indication 40.69 10.29 207 671891 38331 70218015
Epstein-Barr virus infection 40.62 10.29 39 672059 13159 70243187
Therapeutic response decreased 40.55 10.29 356 671742 58097 70198249
Blood pressure increased 40.42 10.29 2179 669919 186338 70070008
Exposure during pregnancy 40.40 10.29 586 671512 87131 70169215
Aplastic anaemia 40.16 10.29 60 672038 16656 70239690
Neutropenic sepsis 40.16 10.29 112 671986 24718 70231628
Mucormycosis 40.00 10.29 13 672085 8001 70248345
Poisoning 39.67 10.29 98 672000 22524 70233822
Cytomegalovirus infection reactivation 39.59 10.29 8 672090 6773 70249573
Blood parathyroid hormone decreased 39.46 10.29 18 672080 9006 70247340
Nephropathy toxic 39.32 10.29 72 672026 18442 70237904
Therapeutic drug monitoring analysis not performed 39.31 10.29 60 672038 1484 70254862
Hip arthroplasty 39.31 10.29 135 671963 27905 70228441
Thrombotic microangiopathy 39.17 10.29 68 672030 17780 70238566
Full blood count abnormal 38.69 10.29 491 671607 33387 70222959
Myxoedema 38.61 10.29 21 672077 117 70256229
Swollen tongue 38.59 10.29 528 671570 36518 70219828
Gestational diabetes 38.59 10.29 135 671963 5866 70250480
Acute graft versus host disease in skin 38.52 10.29 10 672088 7127 70249219
Influenza like illness 37.95 10.29 848 671250 64483 70191863
Device adhesion issue 37.90 10.29 6 672092 6057 70250289
Hypertension 37.80 10.29 3277 668821 292756 69963590
Polyomavirus-associated nephropathy 37.73 10.29 3 672095 5180 70251166
Insomnia 37.69 10.29 2470 669628 215336 70041010
Ankylosing spondylitis 37.52 10.29 33 672065 11613 70244733
Thyroid cancer recurrent 37.41 10.29 13 672085 16 70256330
Anxiety 37.30 10.29 2494 669604 217836 70038510
Disease progression 37.25 10.29 1165 670933 155507 70100839
Sickle cell anaemia with crisis 37.18 10.29 6 672092 5972 70250374
Thyroxine increased 36.98 10.29 40 672058 693 70255653
Graft versus host disease in gastrointestinal tract 36.89 10.29 6 672092 5938 70250408
Transplant dysfunction 36.68 10.29 10 672088 6899 70249447
BK virus infection 36.42 10.29 15 672083 7974 70248372
Cytomegalovirus chorioretinitis 36.09 10.29 4 672094 5294 70251052
Hypophysitis 35.82 10.29 97 672001 3661 70252685
General physical health deterioration 35.50 10.29 2646 669452 233385 70022961
Nervousness 35.10 10.29 450 671648 30670 70225676
Ageusia 34.89 10.29 251 671847 14611 70241735
Amnesia 34.85 10.29 691 671407 51464 70204882
Drug use disorder 34.51 10.29 17 672081 8134 70248212
Status epilepticus 34.43 10.29 118 671980 24408 70231938
Burning sensation 34.17 10.29 697 671401 52173 70204173
Juvenile idiopathic arthritis 33.54 10.29 7 672091 5793 70250553
Pseudomonas infection 33.53 10.29 82 672016 18912 70237434
Dystonia 33.29 10.29 87 672011 19619 70236727
Red blood cell sedimentation rate 32.71 10.29 4 672094 4906 70251440
Plasma cell myeloma 32.68 10.29 492 671606 72709 70183637
Chronic pigmented purpura 32.09 10.29 21 672077 172 70256174
Dyspnoea 31.83 10.29 7985 664113 762075 69494271
Rheumatic fever 31.36 10.29 76 672022 17584 70238762
Trichorrhexis 31.27 10.29 37 672061 710 70255636
Tenderness 31.24 10.29 323 671775 20887 70235459
Body height decreased 30.96 10.29 151 671947 7632 70248714
Reversible airways obstruction 30.86 10.29 55 672043 1552 70254794
Memory impairment 30.49 10.29 1119 670979 91522 70164824
Goitre 30.49 10.29 113 671985 5053 70251293
Cerebrovascular accident 30.48 10.29 1657 670441 141813 70114533
Interstitial lung disease 30.37 10.29 757 671341 103928 70152418
Pulmonary malformation 30.15 10.29 20 672078 168 70256178
Nocardiosis 30.05 10.29 6 672092 5123 70251223
Unintentional medical device removal 29.95 10.29 15 672083 7109 70249237
Feeling cold 29.80 10.29 372 671726 25198 70231148
Foreign body in reproductive tract 29.74 10.29 29 672069 442 70255904
Blood glucose increased 29.68 10.29 1226 670872 101756 70154590
Dyspepsia 29.58 10.29 1077 671021 88000 70168346
Pulmonary tuberculosis 29.42 10.29 19 672079 7826 70248520
Swollen joint count increased 29.34 10.29 53 672045 13647 70242699
Myelodysplastic syndrome 29.21 10.29 164 671934 29621 70226725
Paraesthesia 29.18 10.29 1672 670426 143865 70112481
Coma 29.18 10.29 655 671443 91189 70165157
Acute respiratory distress syndrome 29.17 10.29 250 671848 41004 70215342
Epiphysiolysis 29.16 10.29 16 672082 91 70256255
Swelling face 28.95 10.29 794 671304 62370 70193976
Cardiogenic shock 28.93 10.29 213 671885 36094 70220252
Rash 28.74 10.29 4322 667776 506240 69750106
Hypoglycaemia 28.72 10.29 1130 670968 93234 70163112
Gallbladder disorder 28.64 10.29 275 671823 17437 70238909
Lymphocyte count decreased 28.53 10.29 269 671829 43270 70213076
Oesophageal carcinoma 28.45 10.29 28 672070 9338 70247008
Liver injury 28.43 10.29 250 671848 40785 70215561
Alopecia 28.40 10.29 1564 670534 196926 70059420
Accidental exposure to product 28.31 10.29 153 671945 27898 70228448
Tenosynovitis 28.24 10.29 56 672042 13920 70242426
Drug eruption 28.08 10.29 239 671859 39257 70217089
Diffuse large B-cell lymphoma 28.01 10.29 52 672046 13250 70243096
Product dose omission issue 28 10.29 2409 669689 215059 70041287
Product physical issue 27.85 10.29 88 672010 3626 70252720
Tropical infectious disease 27.73 10.29 12 672086 36 70256310
Respiratory depression 27.58 10.29 131 671967 24700 70231646
Visual impairment 27.56 10.29 974 671124 79276 70177070
Dry eye 27.34 10.29 444 671654 31838 70224508
Jaw disorder 27.33 10.29 103 671995 4643 70251703
Eye swelling 27.29 10.29 343 671755 23271 70233075
Hypersomnia 27.24 10.29 309 671789 20455 70235891
Autoimmune hepatitis 26.98 10.29 185 671913 10601 70245745
Therapy partial responder 26.95 10.29 48 672050 12426 70243920
Pneumonia 26.86 10.29 5110 666988 591122 69665224
Skin necrosis 26.71 10.29 73 672025 16218 70240128
Sedation 26.64 10.29 605 671493 46126 70210220
Product taste abnormal 26.54 10.29 61 672037 2075 70254271
Thyrotoxic crisis 26.37 10.29 44 672054 1176 70255170
Cardiotoxicity 26.34 10.29 40 672058 11030 70245316
Bacteraemia 26.30 10.29 166 671932 29143 70227203
Granulocytopenia 26.27 10.29 182 671916 10465 70245881
Acute lymphocytic leukaemia recurrent 26.22 10.29 7 672091 4897 70251449
Cardiac disorder 26.15 10.29 743 671355 58672 70197674
Oral discomfort 26.11 10.29 158 671940 8673 70247673
Sciatica 26.06 10.29 352 671746 24275 70232071
Haemorrhoids 25.96 10.29 363 671735 25225 70231121
Skin haemorrhage 25.70 10.29 175 671923 10005 70246341
Eating disorder 25.60 10.29 279 671819 18286 70238060
Nasopharyngitis 25.49 10.29 1787 670311 220419 70035927
Spinal stenosis 25.44 10.29 231 671867 14422 70241924
Lip swelling 25.44 10.29 459 671639 33595 70222751
Breast cancer stage I 25.42 10.29 13 672085 6089 70250257
Haematoma 25.21 10.29 619 671479 47799 70208547
Disorientation 25.12 10.29 723 671375 57200 70199146
Device difficult to use 25.05 10.29 40 672058 10809 70245537
Somatic delusion 24.99 10.29 32 672066 668 70255678
Hypoacusis 24.97 10.29 380 671718 26889 70229457
Alanine aminotransferase increased 24.77 10.29 1143 670955 146337 70110009
Product odour abnormal 24.77 10.29 43 672055 1188 70255158
Poisoning deliberate 24.69 10.29 81 672017 16979 70239367
Pneumonia fungal 24.62 10.29 35 672063 9918 70246428
Alanine aminotransferase abnormal 24.59 10.29 24 672074 8035 70248311
Lipodystrophy acquired 24.56 10.29 5 672093 4211 70252135
Arrhythmia 24.40 10.29 701 671397 55442 70200904
Head injury 24.40 10.29 457 671641 33684 70222662
Serotonin syndrome 24.38 10.29 268 671830 41846 70214500
Secondary hypogonadism 24.31 10.29 23 672075 337 70256009
Febrile bone marrow aplasia 24.27 10.29 48 672050 11943 70244403
Systemic infection 24.26 10.29 126 671972 6531 70249815
Blood growth hormone increased 24.22 10.29 31 672067 647 70255699
Rhinitis allergic 24.20 10.29 161 671937 9134 70247212
Enterococcal infection 24.16 10.29 65 672033 14517 70241829
Retinitis 24.10 10.29 5 672093 4155 70252191
Labyrinthitis 24.03 10.29 69 672029 2695 70253651
Diverticulum 23.84 10.29 216 671882 13477 70242869
Incorrect route of product administration 23.80 10.29 150 671948 26342 70230004
Product colour issue 23.76 10.29 32 672066 703 70255643
Paradoxical drug reaction 23.65 10.29 17 672081 6619 70249727
Thyroxine decreased 23.51 10.29 33 672065 755 70255591
Broncholithiasis 23.33 10.29 18 672080 196 70256150
Choking 23.26 10.29 182 671916 10878 70245468
Urine odour abnormal 22.82 10.29 110 671988 5533 70250813
Diffuse large B-cell lymphoma recurrent 22.75 10.29 3 672095 3473 70252873
Retrograde amnesia 22.71 10.29 27 672071 521 70255825
Malabsorption 22.60 10.29 96 672002 4574 70251772
Inner ear disorder 22.59 10.29 27 672071 524 70255822
Haematochezia 22.44 10.29 876 671222 72205 70184141
Change of bowel habit 22.10 10.29 65 672033 2574 70253772
Tri-iodothyronine increased 22.05 10.29 18 672080 214 70256132
Papillitis 21.99 10.29 13 672085 87 70256259
Chest pain 21.98 10.29 2711 669387 248549 70007797
Head discomfort 21.95 10.29 204 671894 12819 70243527
Hiatus hernia 21.92 10.29 301 671797 20833 70235513
Anti-thyroid antibody positive 21.90 10.29 25 672073 461 70255885
Pelvic fracture 21.89 10.29 182 671916 11079 70245267
Blood glucose decreased 21.86 10.29 336 671762 23823 70232523
Intentional self-injury 21.84 10.29 193 671905 31457 70224889
Hypogammaglobulinaemia 21.82 10.29 48 672050 11490 70244856
Nephritic syndrome 21.80 10.29 21 672077 315 70256031
Pneumonia cytomegaloviral 21.73 10.29 8 672090 4553 70251793
Viral mutation identified 21.72 10.29 4 672094 3618 70252728
Cholelithiasis 21.67 10.29 595 671503 46745 70209601
Vaginal haemorrhage 21.58 10.29 291 671807 20061 70236285
Atrioventricular block 21.51 10.29 199 671899 12489 70243857
Posterior reversible encephalopathy syndrome 21.49 10.29 139 671959 24263 70232083
Liver function test abnormal 21.46 10.29 744 671354 60402 70195944
Breast cancer stage III 21.44 10.29 19 672079 6662 70249684
Back pain 21.36 10.29 2907 669191 268245 69988101
Lymphoproliferative disorder 21.25 10.29 12 672086 5317 70251029
Eye irritation 21.25 10.29 260 671838 17528 70238818
Exposure via ingestion 21.19 10.29 10 672088 4905 70251441
Pneumatosis intestinalis 21.08 10.29 15 672083 5872 70250474
Primary hypothyroidism 21.06 10.29 15 672083 143 70256203
Cerebral infarction 20.98 10.29 284 671814 42725 70213621
Bradycardia 20.97 10.29 1410 670688 123205 70133141
Gastric cancer 20.69 10.29 33 672065 8922 70247424
Poor quality product administered 20.62 10.29 74 672024 3257 70253089
Tongue discomfort 20.61 10.29 57 672041 2178 70254168
Hyperhidrosis 20.59 10.29 1480 670618 130106 70126240
Leukopenia 20.58 10.29 813 671285 105747 70150599
Multiple allergies 20.56 10.29 135 671963 7625 70248721
Staphylococcal infection 20.52 10.29 369 671729 53035 70203311
Abdominal distension 20.50 10.29 1200 670898 103469 70152877
Persistent depressive disorder 20.47 10.29 36 672062 1005 70255341
Scleral discolouration 20.41 10.29 26 672072 540 70255806
Immunosuppressant drug level increased 20.37 10.29 27 672071 7880 70248466
Diabetes insipidus 20.32 10.29 93 672005 4578 70251768
Lip blister 20.31 10.29 60 672038 2382 70253964
Intervertebral disc protrusion 20.21 10.29 301 671797 21202 70235144
Skin toxicity 20.21 10.29 23 672075 7175 70249171
Metastatic renal cell carcinoma 20.19 10.29 67 672031 2833 70253513
Sleep disorder due to a general medical condition 20.19 10.29 169 671929 10307 70246039
Medullary thyroid cancer 20.16 10.29 15 672083 154 70256192
Milk-alkali syndrome 20.14 10.29 39 672059 1174 70255172
Metabolic acidosis 20.13 10.29 543 671555 73803 70182543
Soft tissue disorder 20.08 10.29 74 672024 3300 70253046
Kidney transplant rejection 20.05 10.29 40 672058 9921 70246425
Breast cancer stage II 19.98 10.29 13 672085 5333 70251013
Cerebral haematoma 19.94 10.29 129 671969 7249 70249097
Medulloblastoma recurrent 19.87 10.29 14 672084 131 70256215
Pre-existing condition improved 19.87 10.29 97 672001 4905 70251441
Ventricular fibrillation 19.75 10.29 163 671935 26948 70229398
Growth hormone deficiency 19.73 10.29 22 672076 395 70255951
Bladder cancer 19.72 10.29 90 672008 17152 70239194
Platelet count decreased 19.66 10.29 1438 670660 176784 70079562
Virologic failure 19.65 10.29 6 672092 3844 70252502
Drug abuser 19.65 10.29 16 672082 5848 70250498
Pollakiuria 19.64 10.29 435 671663 33026 70223320
Thyroiditis 19.56 10.29 83 672015 3953 70252393
Exposure to toxic agent 19.42 10.29 18 672080 6176 70250170
Low turnover osteopathy 19.38 10.29 50 672048 1832 70254514
Intentional product misuse 19.36 10.29 590 671508 79005 70177341
Adrenal insufficiency 19.32 10.29 341 671757 24854 70231492
Altered state of consciousness 19.26 10.29 265 671833 39757 70216589
Tooth fracture 19.21 10.29 169 671929 10458 70245888
Disability 19.12 10.29 75 672023 14908 70241438
Extremity contracture 19.09 10.29 46 672052 1614 70254732
Blood test abnormal 19.09 10.29 217 671881 14373 70241973
Upper limb fracture 19.00 10.29 235 671863 15884 70240462
Lung cyst 18.90 10.29 18 672080 266 70256080
Brain oedema 18.84 10.29 137 671961 23281 70233065
Lymphadenectomy 18.81 10.29 37 672061 1127 70255219
Thyroid cancer metastatic 18.72 10.29 14 672084 145 70256201
Application site erythema 18.68 10.29 92 672006 4669 70251677
Thyrotoxic periodic paralysis 18.57 10.29 12 672086 96 70256250
Electrocardiogram ST segment elevation 18.55 10.29 27 672071 7577 70248769
Vital capacity decreased 18.35 10.29 41 672057 1368 70254978
Pancreatic neuroendocrine tumour 18.34 10.29 27 672071 646 70255700
Labile hypertension 18.28 10.29 24 672074 514 70255832
Anosmia 18.20 10.29 93 672005 4790 70251556
Exophthalmos 18.15 10.29 44 672054 1550 70254796
Respiratory disorder 18.14 10.29 261 671837 38862 70217484
Gastrointestinal motility disorder 18.02 10.29 102 671996 5464 70250882
Erythema dyschromicum perstans 17.93 10.29 10 672088 59 70256287
Pituitary tumour 17.90 10.29 36 672062 1115 70255231
Wrist fracture 17.86 10.29 165 671933 10351 70245995
Myocardial infarction 17.82 10.29 1392 670706 170253 70086093
Spinal osteoarthritis 17.76 10.29 223 671875 15125 70241221
Cytopenia 17.75 10.29 94 672004 17229 70239117
Product measured potency issue 17.73 10.29 15 672083 188 70256158
Systemic candida 17.73 10.29 18 672080 5916 70250430
Cystitis 17.70 10.29 576 671522 46365 70209981
Hyperchromic anaemia 17.67 10.29 14 672084 159 70256187
Acute graft versus host disease in intestine 17.67 10.29 7 672091 3809 70252537
Endocrine ophthalmopathy 17.56 10.29 24 672074 535 70255811
Increased tendency to bruise 17.56 10.29 154 671944 9521 70246825
Oropharyngeal pain 17.51 10.29 1097 671001 95213 70161133
Thyroxine abnormal 17.44 10.29 6 672092 7 70256339
Drug level increased 17.36 10.29 242 671856 36227 70220119
Multiple drug therapy 17.34 10.29 68 672030 3124 70253222
Follicular thyroid cancer 17.33 10.29 11 672087 85 70256261
Staphylococcal sepsis 17.27 10.29 67 672031 13360 70242986
Hyperbilirubinaemia 17.22 10.29 134 671964 22434 70233912
Bladder disorder 17.21 10.29 136 671962 8153 70248193
Cryptococcosis 17.18 10.29 5 672093 3305 70253041
Endocrine disorder 17.17 10.29 28 672070 734 70255612
Weight increased 17.15 10.29 2582 669516 239749 70016597
Adverse event 17.09 10.29 348 671750 49113 70207233
Amniotic fluid volume increased 17.04 10.29 13 672085 139 70256207
Breast discomfort 16.91 10.29 19 672079 344 70256002
Knee arthroplasty 16.91 10.29 226 671872 34075 70222271
Rapid eye movement sleep behaviour disorder 16.83 10.29 19 672079 346 70256000
Adenoiditis 16.78 10.29 8 672090 32 70256314
Product solubility abnormal 16.77 10.29 30 672068 849 70255497
Palmar-plantar erythrodysaesthesia syndrome 16.75 10.29 390 671708 29857 70226489
Transcription medication error 16.74 10.29 19 672079 348 70255998
Hypertensive crisis 16.71 10.29 266 671832 18996 70237350
Full blood count decreased 16.69 10.29 319 671779 23599 70232747
Pneumonia bacterial 16.66 10.29 91 672007 16550 70239796
Ascites 16.60 10.29 500 671598 67047 70189299
Hypoxia 16.57 10.29 719 671379 92625 70163721
Neurologic neglect syndrome 16.57 10.29 55 672043 2326 70254020
Fungaemia 16.56 10.29 9 672089 4073 70252273
Total lung capacity abnormal 16.45 10.29 14 672084 177 70256169
Traumatic ulcer 16.43 10.29 9 672089 51 70256295
Anaphylactic shock 16.41 10.29 213 671885 32277 70224069
Cataract 16.38 10.29 664 671434 54981 70201365
Nasal congestion 16.30 10.29 770 671328 64902 70191444
Granuloma 16.27 10.29 30 672068 7665 70248681
Renal impairment 16.26 10.29 1159 670939 142778 70113568
Kounis syndrome 16.22 10.29 6 672092 3405 70252941
Upper-airway cough syndrome 16.19 10.29 152 671946 9579 70246767
Oculogyric crisis 16.14 10.29 3 672095 2695 70253651
Lymph node calcification 16.12 10.29 19 672079 363 70255983
Aggression 16.10 10.29 343 671755 48103 70208243
Arterial occlusive disease 16.06 10.29 127 671971 7615 70248731
Lactose intolerance 16.06 10.29 51 672047 2107 70254239
Thyroglobulin decreased 16.02 10.29 5 672093 3 70256343
Venoocclusive disease 15.99 10.29 10 672088 4190 70252156
Potassium wasting nephropathy 15.76 10.29 13 672085 157 70256189
Stenotrophomonas infection 15.74 10.29 6 672092 3343 70253003
Cervicogenic headache 15.71 10.29 7 672091 23 70256323
Intercepted product preparation error 15.67 10.29 3 672095 2639 70253707
Presbyacusis 15.63 10.29 3 672095 2634 70253712
Pregnancy 15.55 10.29 147 671951 23634 70232712
Blood loss anaemia 15.52 10.29 207 671891 14234 70242112
International normalised ratio increased 15.52 10.29 924 671174 79802 70176544
Gastritis 15.50 10.29 542 671556 44049 70212297
Tooth dislocation 15.49 10.29 7 672091 24 70256322
Delayed graft function 15.47 10.29 6 672092 3307 70253039
Vascular stent thrombosis 15.45 10.29 7 672091 3516 70252830
Meniere's disease 15.43 10.29 13 672085 162 70256184
Intercapillary glomerulosclerosis 15.38 10.29 9 672089 59 70256287
Abdominal pain lower 15.37 10.29 363 671735 27853 70228493
Rib deformity 15.36 10.29 13 672085 163 70256183
Dysstasia 15.31 10.29 329 671769 24850 70231496
Scar 15.28 10.29 201 671897 13780 70242566
Product administered to patient of inappropriate age 15.27 10.29 14 672084 4829 70251517
Diabetic ketoacidosis 15.26 10.29 399 671699 31113 70225233
Intervertebral disc degeneration 15.26 10.29 200 671898 13700 70242646
Faeces discoloured 15.25 10.29 347 671751 26462 70229884
Blood calcium increased 15.22 10.29 141 671957 8852 70247494
Gingival pain 15.22 10.29 113 671985 6644 70249702
Cystic fibrosis 15.21 10.29 11 672087 4270 70252076
Abdominal pain 15.20 10.29 3560 668538 338567 69917779
Device related infection 15.17 10.29 214 671884 31971 70224375
Device use error 15.17 10.29 25 672073 6671 70249675
Eye pain 15.15 10.29 427 671671 33675 70222671
Hepatitis B 15.15 10.29 34 672064 8080 70248266
Sinus bradycardia 15.12 10.29 311 671787 23312 70233034
Femur fracture 15.11 10.29 449 671649 35683 70220663
Injection site mass 15.05 10.29 251 671847 18092 70238254
Temperature regulation disorder 15.05 10.29 12 672086 4432 70251914
Pleural neoplasm 14.99 10.29 18 672080 351 70255995
Rheumatoid lung 14.97 10.29 7 672091 3452 70252894
Product blister packaging issue 14.92 10.29 13 672085 170 70256176
Cytomegalovirus colitis 14.83 10.29 11 672087 4215 70252131
Listless 14.80 10.29 70 672028 3493 70252853
Decreased bronchial secretion 14.78 10.29 9 672089 64 70256282
Shock 14.69 10.29 282 671816 40143 70216203
Vessel puncture site haemorrhage 14.68 10.29 13 672085 174 70256172
Polyglandular autoimmune syndrome type II 14.68 10.29 7 672091 28 70256318
Tonsillar cyst 14.67 10.29 4 672094 0 70256346
Magnetic resonance imaging thoracic abnormal 14.64 10.29 6 672092 15 70256331
N-terminal prohormone brain natriuretic peptide abnormal 14.56 10.29 15 672083 245 70256101
Ileus paralytic 14.55 10.29 39 672059 8722 70247624
Atrioventricular block first degree 14.55 10.29 172 671926 11501 70244845
Parainfluenzae virus infection 14.51 10.29 16 672082 5064 70251282
Drug specific antibody present 14.49 10.29 20 672078 5738 70250608
Skin exfoliation 14.49 10.29 581 671517 48045 70208301
Neuroleptic malignant syndrome 14.46 10.29 167 671931 25840 70230506
Viraemia 14.42 10.29 3 672095 2489 70253857
Impaired driving ability 14.42 10.29 87 672011 4770 70251576
Depression 14.42 10.29 2123 669975 196851 70059495
Vaccination site reaction 14.39 10.29 11 672087 118 70256228
Intentional underdose 14.39 10.29 49 672049 2100 70254246
Seronegative arthritis 14.38 10.29 7 672091 3372 70252974
Anaemia vitamin B12 deficiency 14.37 10.29 24 672074 642 70255704
Feeling jittery 14.35 10.29 170 671928 11373 70244973
Respiratory tract malformation 14.33 10.29 10 672088 92 70256254
Anaemia folate deficiency 14.31 10.29 16 672082 288 70256058
Bacterial sepsis 14.31 10.29 32 672066 7615 70248731
Speech disorder 14.30 10.29 601 671497 49979 70206367
Pleural fibrosis 14.24 10.29 11 672087 4128 70252218
Erectile dysfunction 14.23 10.29 73 672025 13489 70242857
Autoimmune hypothyroidism 14.22 10.29 14 672084 216 70256130
Throat clearing 14.19 10.29 42 672056 1669 70254677
Pseudomonal sepsis 14.17 10.29 19 672079 5518 70250828
Supraventricular extrasystoles 14.16 10.29 104 671994 6094 70250252
Neuromyopathy 14.15 10.29 38 672060 1427 70254919
Empty sella syndrome 14.13 10.29 9 672089 70 70256276
Anal prolapse 14.13 10.29 9 672089 70 70256276
Cortisol decreased 14.13 10.29 45 672053 1862 70254484
Acute hepatic failure 14.13 10.29 181 671917 27491 70228855
Hair colour changes 14.12 10.29 74 672024 3849 70252497
Abnormal weight gain 14.08 10.29 51 672047 2255 70254091
Blood sodium decreased 14.02 10.29 389 671709 30609 70225737
Meningitis cryptococcal 14.00 10.29 7 672091 3321 70253025
Hormone level abnormal 13.96 10.29 43 672055 1747 70254599
Panic disorder 13.96 10.29 59 672039 2805 70253541
Urinary incontinence 13.92 10.29 463 671635 37379 70218967
Tuberculosis 13.89 10.29 83 672015 14765 70241581
Hyperthermia malignant 13.85 10.29 4 672094 2657 70253689
Cerebral microangiopathy 13.82 10.29 15 672083 261 70256085
Varicose vein 13.79 10.29 75 672023 3957 70252389
Drug level decreased 13.79 10.29 67 672031 12557 70243789
Wrong patient received product 13.79 10.29 81 672017 4399 70251947
Paronychia 13.73 10.29 29 672069 7045 70249301
Intermenstrual bleeding 13.70 10.29 91 672007 5159 70251187
Needle issue 13.68 10.29 161 671937 10754 70245592
Blood calcitonin increased 13.63 10.29 7 672091 34 70256312
Abnormal uterine bleeding 13.62 10.29 28 672070 881 70255465
Retching 13.61 10.29 220 671878 15759 70240587
Alcohol abuse 13.61 10.29 17 672081 5090 70251256
Complications of transplanted kidney 13.59 10.29 22 672076 5912 70250434
Musculoskeletal discomfort 13.55 10.29 241 671857 17591 70238755
Pneumonia viral 13.53 10.29 129 671969 8163 70248183
Dementia 13.52 10.29 292 671806 22073 70234273
Maternal exposure timing unspecified 13.49 10.29 13 672085 4378 70251968
Deep brain stimulation 13.48 10.29 8 672090 54 70256292
Pulmonary valve incompetence 13.47 10.29 42 672056 1718 70254628
Dyspnoea exertional 13.47 10.29 889 671209 77541 70178805
Infection reactivation 13.44 10.29 3 672095 2370 70253976
COVID-19 pneumonia 13.44 10.29 138 671960 21831 70234515
Frontotemporal dementia 13.40 10.29 22 672076 580 70255766
Blood potassium decreased 13.38 10.29 510 671588 41911 70214435
Bundle branch block left 13.30 10.29 154 671944 10245 70246101
Bronchitis 13.29 10.29 1287 670811 115956 70140390
Pituitary cyst 13.28 10.29 5 672093 9 70256337
Cough 13.28 10.29 3373 668725 322004 69934342
Stress fracture 13.27 10.29 98 672000 5752 70250594
Acute lung injury 13.26 10.29 5 672093 2804 70253542
Skin irritation 13.24 10.29 148 671950 9761 70246585
Pulmonary alveolar haemorrhage 13.17 10.29 52 672046 10317 70246029
Immune effector cell-associated neurotoxicity syndrome 13.15 10.29 11 672087 3967 70252379
Gingival disorder 13.14 10.29 66 672032 3376 70252970
Immediate post-injection reaction 13.09 10.29 16 672082 318 70256028
Mineral deficiency 13.01 10.29 7 672091 38 70256308
Red blood cell sedimentation rate increased 13.01 10.29 273 671825 38369 70217977
Cytomegalovirus test positive 13.01 10.29 20 672078 5488 70250858
Appendicitis 12.93 10.29 99 671999 16634 70239712
Piloerection 12.93 10.29 19 672079 454 70255892
Hyponatraemic seizure 12.89 10.29 20 672078 502 70255844
Basedow's disease 12.88 10.29 14 672084 244 70256102
Forced vital capacity decreased 12.88 10.29 39 672059 1570 70254776
Inflammation 12.74 10.29 612 671486 78053 70178293
Pneumonia aspiration 12.73 10.29 472 671626 61817 70194529
Body height increased 12.66 10.29 10 672088 113 70256233
Tinnitus 12.65 10.29 440 671658 35736 70220610
Bone loss 12.62 10.29 51 672047 2376 70253970
Chromaturia 12.61 10.29 302 671796 23226 70233120
Tongue haematoma 12.59 10.29 13 672085 213 70256133
Miosis 12.58 10.29 80 672018 14021 70242325
Spondylolisthesis 12.54 10.29 58 672040 2868 70253478
Polyhydramnios 12.52 10.29 37 672061 1469 70254877
Cholecystitis chronic 12.51 10.29 140 671958 9236 70247110
Sneezing 12.49 10.29 228 671870 16723 70239623
Dilatation atrial 12.47 10.29 66 672032 3446 70252900
Sexual dysfunction 12.47 10.29 28 672070 6653 70249693
Laryngeal injury 12.46 10.29 4 672094 3 70256343
Ecchymosis 12.46 10.29 198 671900 14134 70242212
Orthostatic intolerance 12.46 10.29 41 672057 1726 70254620
Eye disorder 12.45 10.29 271 671827 20514 70235832
Product dispensing error 12.45 10.29 171 671927 11837 70244509
Coronary arterial stent insertion 12.41 10.29 23 672075 5864 70250482
Gastrointestinal tract mucosal pigmentation 12.40 10.29 28 672070 941 70255405
Brain natriuretic peptide abnormal 12.40 10.29 23 672075 670 70255676
Therapeutic product effect variable 12.35 10.29 40 672058 1670 70254676
Therapeutic product effect increased 12.35 10.29 35 672063 1357 70254989
Adverse drug reaction 12.34 10.29 398 671700 52946 70203400
Lipoma excision 12.34 10.29 5 672093 12 70256334
Madarosis 12.32 10.29 52 672046 2471 70253875
Rotator cuff repair 12.27 10.29 39 672059 1612 70254734
Secondary immunodeficiency 12.27 10.29 6 672092 2883 70253463
Sinus disorder 12.27 10.29 250 671848 18709 70237637
Nerve compression 12.26 10.29 125 671973 8053 70248293
Vulvovaginal discomfort 12.21 10.29 39 672059 1616 70254730
Bacterial infection 12.19 10.29 177 671921 26315 70230031
Angina pectoris 12.16 10.29 568 671530 47815 70208531
Hypoglycaemic unconsciousness 12.13 10.29 31 672067 1129 70255217
Schizophrenia 12.13 10.29 101 671997 16667 70239679
Germ cell cancer 12.08 10.29 11 672087 153 70256193
Mean cell haemoglobin concentration increased 12.03 10.29 25 672073 793 70255553
Nephrectomy 11.98 10.29 41 672057 1762 70254584
Basal cell carcinoma 11.97 10.29 236 671862 33462 70222884
Rectal polyp 11.96 10.29 36 672062 1444 70254902
Sprue-like enteropathy 11.96 10.29 30 672068 1080 70255266
Polyp 11.93 10.29 112 671986 7058 70249288
Groin pain 11.88 10.29 170 671928 11872 70244474
Gastrointestinal tract irritation 11.84 10.29 20 672078 540 70255806
Thyroid mass 11.83 10.29 65 672033 3443 70252903
Tracheal fistula 11.78 10.29 10 672088 126 70256220
Oesophageal achalasia 11.75 10.29 23 672075 698 70255648
Upper respiratory tract inflammation 11.73 10.29 12 672086 3930 70252416
Starvation ketoacidosis 11.71 10.29 10 672088 127 70256219
Emotional distress 11.70 10.29 447 671651 36741 70219605
Urine sodium decreased 11.70 10.29 14 672084 272 70256074
Recalled product 11.70 10.29 27 672071 921 70255425
Vomiting 11.69 10.29 5985 666113 587126 69669220
Senile osteoporosis 11.67 10.29 9 672089 98 70256248
Transplant failure 11.66 10.29 13 672085 4094 70252252
Neutrophil count increased 11.65 10.29 181 671917 26614 70229732
Fear of injection 11.62 10.29 29 672069 6643 70249703
Superficial vein prominence 11.61 10.29 8 672090 72 70256274
Emotional disorder 11.61 10.29 183 671915 13043 70243303
Expired product administered 11.60 10.29 102 671996 6311 70250035
Affect lability 11.56 10.29 147 671951 9999 70246347
Congenital central nervous system anomaly 11.55 10.29 5 672093 15 70256331
Metastases to neck 11.55 10.29 6 672092 30 70256316
Ocular discomfort 11.51 10.29 76 672022 4301 70252045
Diffuse alveolar damage 11.49 10.29 9 672089 3354 70252992
Candida infection 11.48 10.29 244 671854 34229 70222117
Gastric pH increased 11.47 10.29 7 672091 50 70256296
Oesophageal disorder 11.47 10.29 51 672047 2479 70253867
Supraventricular tachyarrhythmia 11.44 10.29 9 672089 101 70256245
Hypotensive transfusion reaction 11.43 10.29 8 672090 74 70256272
Suspected suicide 11.41 10.29 44 672054 8790 70247556
Disturbance in social behaviour 11.41 10.29 13 672085 4054 70252292
Incorrect dose administered 11.41 10.29 756 671342 65963 70190383
Blood urea nitrogen/creatinine ratio increased 11.39 10.29 25 672073 824 70255522
Mydriasis 11.37 10.29 98 672000 16055 70240291
Lichen nitidus 11.34 10.29 8 672090 75 70256271
Anaemia postoperative 11.34 10.29 40 672058 1745 70254601
Application site vesicles 11.32 10.29 33 672065 1300 70255046
Joint laxity 11.32 10.29 4 672094 2335 70254011
Delirium 11.21 10.29 585 671513 74029 70182317
Tonsillar disorder 11.20 10.29 29 672069 1065 70255281
Rectocele 11.18 10.29 20 672078 566 70255780
Lactation disorder 11.18 10.29 12 672086 206 70256140
Angle closure glaucoma 11.11 10.29 54 672044 2725 70253621
Fanconi syndrome acquired 11.11 10.29 5 672093 2522 70253824
Chondromalacia 11.11 10.29 11 672087 171 70256175
Chronic fatigue syndrome 11.11 10.29 31 672067 1191 70255155
Mycobacterial infection 11.10 10.29 10 672088 3478 70252868
Intervertebral disc disorder 11.09 10.29 78 672020 4507 70251839
Generalised tonic-clonic seizure 11.09 10.29 305 671793 41356 70214990
Temperature intolerance 11.08 10.29 129 671969 8594 70247752
Cardiac pacemaker insertion 11.08 10.29 88 672010 5284 70251062
Fractured coccyx 11.03 10.29 27 672071 957 70255389
Application site pruritus 11.01 10.29 65 672033 3536 70252810
Hypothyroidic goitre 11.01 10.29 3 672095 0 70256346
Invasive papillary breast carcinoma 11.01 10.29 3 672095 0 70256346
Body height abnormal 11.01 10.29 3 672095 0 70256346
Thyroid pain 11.01 10.29 3 672095 0 70256346
Tri-iodothyronine free 11.01 10.29 3 672095 0 70256346
Clear cell endometrial carcinoma 11.01 10.29 3 672095 0 70256346
Synovial cyst removal 11.01 10.29 3 672095 0 70256346
Primary hyperthyroidism 11.01 10.29 3 672095 0 70256346
Blood proinsulin increased 11.01 10.29 3 672095 0 70256346
Antinuclear antibody positive 11.00 10.29 106 671992 6727 70249619
Pituitary haemorrhage 10.98 10.29 14 672084 291 70256055
Skin ulcer 10.95 10.29 360 671738 47785 70208561
Eructation 10.95 10.29 141 671957 9619 70246727
Gene mutation 10.94 10.29 4 672094 2287 70254059
Thyroglobulin increased 10.93 10.29 7 672091 55 70256291
Thyroid neoplasm 10.93 10.29 56 672042 2887 70253459
Immunisation reaction 10.91 10.29 12 672086 212 70256134
Vulvovaginal mycotic infection 10.89 10.29 70 672028 3925 70252421
Pain threshold decreased 10.88 10.29 5 672093 18 70256328
Lethargy 10.86 10.29 841 671257 74409 70181937
Lens disorder 10.82 10.29 10 672088 142 70256204
Sensory level abnormal 10.82 10.29 10 672088 142 70256204
Neck pain 10.82 10.29 752 671346 65905 70190441
Muscle fatigue 10.81 10.29 60 672038 3191 70253155
Prostate cancer metastatic 10.80 10.29 13 672085 3956 70252390
Hair texture abnormal 10.78 10.29 59 672039 3121 70253225
Coordination abnormal 10.78 10.29 213 671885 15853 70240493
Vertigo positional 10.77 10.29 57 672041 2976 70253370
Hair disorder 10.77 10.29 27 672071 972 70255374
Embedded device 10.75 10.29 55 672043 2834 70253512
Pseudomembranous colitis 10.74 10.29 20 672078 5091 70251255
Acetabulum fracture 10.71 10.29 19 672079 534 70255812
Neoplasm recurrence 10.71 10.29 69 672029 3872 70252474
Metastases to pituitary gland 10.68 10.29 5 672093 19 70256327
Vitamin D deficiency 10.67 10.29 172 671926 12315 70244031
Oropharyngeal swelling 10.64 10.29 31 672067 1221 70255125
Retroplacental haematoma 10.63 10.29 9 672089 113 70256233
Pneumonia pseudomonal 10.62 10.29 21 672077 5225 70251121
Product packaging confusion 10.61 10.29 12 672086 219 70256127
Endometrial thickening 10.58 10.29 13 672085 260 70256086
Disseminated tuberculosis 10.56 10.29 14 672084 4086 70252260
Ear discomfort 10.54 10.29 115 671983 7539 70248807
Distributive shock 10.53 10.29 4 672094 2233 70254113
Painful respiration 10.53 10.29 59 672039 3149 70253197
Carcinoid tumour of the stomach 10.52 10.29 11 672087 183 70256163
Pulmonary haemorrhage 10.52 10.29 81 672017 13592 70242754
Post procedural hypothyroidism 10.50 10.29 9 672089 115 70256231
Superficial injury of eye 10.49 10.29 10 672088 148 70256198
Onychoclasis 10.47 10.29 82 672016 4902 70251444
Chest discomfort 10.47 10.29 1339 670759 123042 70133304
Colitis ulcerative 10.47 10.29 243 671855 33680 70222666
Myelopathy 10.46 10.29 15 672083 4236 70252110
Dislocation of vertebra 10.46 10.29 19 672079 4881 70251465
Progressive multifocal leukoencephalopathy 10.44 10.29 124 671974 19090 70237256
Aortic intramural haematoma 10.44 10.29 9 672089 116 70256230
Thirst 10.43 10.29 196 671902 14453 70241893
Pharyngitis 10.43 10.29 133 671965 20218 70236128
Tooth disorder 10.43 10.29 299 671799 23639 70232707
Barrett's oesophagus 10.40 10.29 23 672075 762 70255584
Sputum increased 10.39 10.29 14 672084 4058 70252288
Toxic anterior segment syndrome 10.38 10.29 6 672092 2624 70253722
Seizure 10.37 10.29 1503 670595 176459 70079887
Nasal obstruction 10.33 10.29 36 672062 1561 70254785
Sinusitis 10.32 10.29 1425 670673 167770 70088576
Bronchiectasis 10.31 10.29 100 671998 15997 70240349
Limb discomfort 10.31 10.29 361 671737 29344 70227002

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Small for dates baby 30.84 17.65 147 2165 2662 84818
Premature baby 28.90 17.65 36 2276 3892 83588
Atrial septal defect 19.51 17.65 141 2171 2978 84502

Pharmacologic Action:

SourceCodeDescription
ATC H03AA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
THYROID PREPARATIONS
Thyroid hormones
FDA CS M0021504 Thyroxine
FDA EPC N0000175945 l-Thyroxine
CHEBI has role CHEBI:50671 antithyroid drugs
CHEBI has role CHEBI:60311 thyroid hormones
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:52290 mitogens
CHEBI has role CHEBI:53000 epitope role

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Goiter indication 3716002 DOID:12176
Hashimoto thyroiditis indication 21983002
Hypothyroidism indication 40930008 DOID:1459
Myxedema indication 43153006 DOID:11634
Hyperlipidemia indication 55822004 DOID:1168
Congenital hypothyroidism indication 190268003 DOID:0050328
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Diagnostic Test for Thyroid Dysfunction indication
Myxedema coma off-label use 21263006
Myocardial infarction contraindication 22298006 DOID:5844
Thyrotoxic crisis contraindication 29028009 DOID:12837
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Osteoporosis contraindication 64859006 DOID:11476
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Angina pectoris contraindication 194828000
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000
Disorder of coronary artery contraindication 414024009




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Replacement therapy for diminished thyroid function Indication

🐶 Veterinary products

ProductApplicantIngredients
Thyro-Tabs Canine Lloyd Inc. 1
ThyroKare Neogen Corp. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 6.63 acidic
pKa3 8.6 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.025MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.05MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.075MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.088MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.112MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.125MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.137MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.15MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.175MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.1MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.2MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** LEVOXYL KING PHARMS N021301 May 25, 2001 DISCN TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thyroid hormone receptor alpha Nuclear hormone receptor AGONIST EC50 7.72 CHEMBL IUPHAR
Thyroid hormone receptor beta Nuclear hormone receptor AGONIST IC50 8.52 IUPHAR CHEMBL
Transthyretin Secreted IC50 4.98 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor Kd 6.40 CHEMBL
Retinoic acid receptor RXR-alpha Nuclear hormone receptor Kd 6.03 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.10 CHEMBL
THAP domain-containing protein 1 Unclassified WOMBAT-PK
Macrophage migration inhibitory factor Unclassified IC50 4.80 CHEMBL
Malate dehydrogenase, mitochondrial Enzyme IC50 4.36 CHEMBL
Thyroid hormone receptor beta Transcription factor IC50 7.46 CHEMBL

External reference:

IDSource
4017826 VUID
N0000179290 NUI
D01010 KEGG_DRUG
55-03-8 SECONDARY_CAS_RN
6106-07-6 SECONDARY_CAS_RN
4017826 VANDF
4022126 VANDF
CHEBI:18332 CHEBI
CHEMBL1624 ChEMBL_ID
CHEMBL2103741 ChEMBL_ID
CHEMBL559 ChEMBL_ID
CHEMBL42115 ChEMBL_ID
DB00451 DRUGBANK_ID
Q51BO43MG4 UNII
10582 RXNORM
1842 MMSL
4976 MMSL
d00278 MMSL
002132 NDDF
004881 NDDF
005896 NDDF
126202002 SNOMEDCT_US
38076006 SNOMEDCT_US
710809001 SNOMEDCT_US
73187006 SNOMEDCT_US
768532006 SNOMEDCT_US
783637002 SNOMEDCT_US
C0040165 UMLSCUI
D013974 MESH_DESCRIPTOR_UI
T44 PDB_CHEM_ID
453 INN_ID
5819 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-3727 TABLET 137 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-3727 TABLET 137 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4341 TABLET 25 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4341 TABLET 25 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4552 TABLET 50 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4552 TABLET 50 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-5182 TABLET 75 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-5182 TABLET 75 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6594 TABLET 88 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6594 TABLET 88 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6624 TABLET 100 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6624 TABLET 100 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7068 TABLET 125 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7068 TABLET 125 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7069 TABLET 150 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7069 TABLET 150 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7070 TABLET 175 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7070 TABLET 175 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7148 TABLET 200 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7148 TABLET 200 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7149 TABLET 300 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7149 TABLET 300 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-9296 TABLET 112 ug ORAL NDA 26 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-9296 TABLET 112 ug ORAL NDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1800 TABLET 25 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1803 TABLET 50 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1805 TABLET 75 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1807 TABLET 88 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1809 TABLET 100 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1811 TABLET 112 ug ORAL ANDA 26 sections