Stem definition | Drug id | CAS RN |
---|---|---|
2646 | 51-48-9 |
Dose | Unit | Route |
---|---|---|
0.15 | mg | O |
0.15 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.00 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.01 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 21, 2000 | FDA | STEVENS J | |
Jan. 23, 2020 | PMDA | Aska Pharmaceutical Co., Ltd |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 1281.58 | 10.65 | 45 | 624142 | 120121 | 49860816 |
Systemic lupus erythematosus | 967.74 | 10.65 | 268 | 623919 | 140354 | 49840583 |
Drug ineffective | 916.68 | 10.65 | 6145 | 618042 | 813188 | 49167749 |
Contraindicated product administered | 897.19 | 10.65 | 357 | 623830 | 148601 | 49832336 |
Blood thyroid stimulating hormone increased | 886.68 | 10.65 | 677 | 623510 | 5415 | 49975522 |
Glossodynia | 880.49 | 10.65 | 177 | 624010 | 115392 | 49865545 |
Hand deformity | 753.83 | 10.65 | 158 | 624029 | 100041 | 49880896 |
Treatment failure | 735.41 | 10.65 | 390 | 623797 | 137247 | 49843690 |
Anti-cyclic citrullinated peptide antibody positive | 678.33 | 10.65 | 50 | 624137 | 70537 | 49910400 |
Synovitis | 658.73 | 10.65 | 353 | 623834 | 123512 | 49857425 |
Pericarditis | 581.82 | 10.65 | 129 | 624058 | 78560 | 49902377 |
Drug intolerance | 580.49 | 10.65 | 1140 | 623047 | 217964 | 49762973 |
Maternal exposure during pregnancy | 561.11 | 10.65 | 687 | 623500 | 159091 | 49821846 |
Infusion related reaction | 555.42 | 10.65 | 768 | 623419 | 168789 | 49812148 |
Hypothyroidism | 501.86 | 10.65 | 1222 | 622965 | 32903 | 49948034 |
Arthropathy | 500.53 | 10.65 | 732 | 623455 | 157174 | 49823763 |
Wound | 495.06 | 10.65 | 350 | 623837 | 105444 | 49875493 |
Rheumatoid factor positive | 437.26 | 10.65 | 51 | 624136 | 49808 | 49931129 |
Drug hypersensitivity | 425.94 | 10.65 | 1624 | 622563 | 249386 | 49731551 |
Duodenal ulcer perforation | 425.11 | 10.65 | 37 | 624150 | 45574 | 49935363 |
Therapeutic product effect decreased | 411.51 | 10.65 | 651 | 623536 | 135399 | 49845538 |
Abdominal discomfort | 381.84 | 10.65 | 1516 | 622671 | 230125 | 49750812 |
Off label use | 378.94 | 10.65 | 3884 | 620303 | 470542 | 49510395 |
Discomfort | 351.60 | 10.65 | 494 | 623693 | 107886 | 49873051 |
Swelling | 349.47 | 10.65 | 1286 | 622901 | 199586 | 49781351 |
Helicobacter infection | 346.77 | 10.65 | 92 | 624095 | 49610 | 49931327 |
Joint swelling | 341.18 | 10.65 | 1710 | 622477 | 243576 | 49737361 |
Blood thyroid stimulating hormone abnormal | 341.08 | 10.65 | 172 | 624015 | 573 | 49980364 |
Hepatic enzyme increased | 333.10 | 10.65 | 751 | 623436 | 136629 | 49844308 |
Folliculitis | 320.49 | 10.65 | 50 | 624137 | 39175 | 49941762 |
Lower respiratory tract infection | 314.74 | 10.65 | 428 | 623759 | 94773 | 49886164 |
Muscle injury | 313.18 | 10.65 | 43 | 624144 | 37068 | 49943869 |
Hyperthyroidism | 279.88 | 10.65 | 523 | 623664 | 11652 | 49969285 |
Alopecia | 270.91 | 10.65 | 1839 | 622348 | 243208 | 49737729 |
Blood thyroid stimulating hormone decreased | 269.89 | 10.65 | 294 | 623893 | 3878 | 49977059 |
Sleep disorder due to general medical condition, insomnia type | 259.39 | 10.65 | 39 | 624148 | 31408 | 49949529 |
Product use issue | 248.14 | 10.65 | 975 | 623212 | 148500 | 49832437 |
Fall | 246.35 | 10.65 | 5632 | 618555 | 329300 | 49651637 |
Rheumatoid arthritis | 245.85 | 10.65 | 1477 | 622710 | 201073 | 49779864 |
Completed suicide | 242.14 | 10.65 | 825 | 623362 | 131064 | 49849873 |
Toxicity to various agents | 238.67 | 10.65 | 1587 | 622600 | 210912 | 49770025 |
Exposure during pregnancy | 226.92 | 10.65 | 750 | 623437 | 120265 | 49860672 |
Hypersensitivity | 221.02 | 10.65 | 1649 | 622538 | 213512 | 49767425 |
Thyroid function test abnormal | 219.38 | 10.65 | 237 | 623950 | 3095 | 49977842 |
Blood thyroid stimulating hormone normal | 203.58 | 10.65 | 71 | 624116 | 52 | 49980885 |
Asthenia | 180.41 | 10.65 | 5181 | 619006 | 313861 | 49667076 |
Irritable bowel syndrome | 172.25 | 10.65 | 229 | 623958 | 51212 | 49929725 |
Dizziness | 172.08 | 10.65 | 5536 | 618651 | 340833 | 49640104 |
Infection | 168.84 | 10.65 | 1344 | 622843 | 171610 | 49809327 |
Product substitution issue | 159.36 | 10.65 | 457 | 623730 | 13600 | 49967337 |
Palpitations | 157.34 | 10.65 | 1821 | 622366 | 92685 | 49888252 |
Pain | 153.80 | 10.65 | 5718 | 618469 | 573185 | 49407752 |
Myalgia | 153.16 | 10.65 | 2267 | 621920 | 122052 | 49858885 |
Drug abuse | 151.67 | 10.65 | 319 | 623868 | 59527 | 49921410 |
Muscle spasms | 139.91 | 10.65 | 2251 | 621936 | 123302 | 49857635 |
Rash | 139.24 | 10.65 | 4222 | 619965 | 433249 | 49547688 |
Hyponatraemia | 129.51 | 10.65 | 1781 | 622406 | 94358 | 49886579 |
Febrile neutropenia | 129.25 | 10.65 | 692 | 623495 | 96975 | 49883962 |
Gastrointestinal disorder | 125.14 | 10.65 | 669 | 623518 | 93787 | 49887150 |
Impaired healing | 124.31 | 10.65 | 442 | 623745 | 69344 | 49911593 |
Drug resistance | 118.36 | 10.65 | 43 | 624144 | 18946 | 49961991 |
Atrial fibrillation | 117.80 | 10.65 | 1836 | 622351 | 99909 | 49881028 |
Ill-defined disorder | 116.54 | 10.65 | 319 | 623868 | 54335 | 49926602 |
Blister | 115.94 | 10.65 | 600 | 623587 | 84818 | 49896119 |
Feeling abnormal | 112.33 | 10.65 | 2173 | 622014 | 123319 | 49857618 |
Product use in unapproved indication | 111.58 | 10.65 | 903 | 623284 | 114916 | 49866021 |
Balance disorder | 109.46 | 10.65 | 1342 | 622845 | 69248 | 49911689 |
Thyroid disorder | 103.37 | 10.65 | 368 | 623819 | 12309 | 49968628 |
Swollen joint count increased | 100.98 | 10.65 | 29 | 624158 | 14844 | 49966093 |
Stomatitis | 100.92 | 10.65 | 783 | 623404 | 100561 | 49880376 |
Constipation | 99.32 | 10.65 | 2996 | 621191 | 182712 | 49798225 |
Intentional overdose | 99.03 | 10.65 | 415 | 623772 | 62089 | 49918848 |
Rheumatic fever | 98.86 | 10.65 | 42 | 624145 | 16825 | 49964112 |
Musculoskeletal stiffness | 97.08 | 10.65 | 1064 | 623123 | 127417 | 49853520 |
Red blood cell sedimentation rate abnormal | 96.91 | 10.65 | 40 | 624147 | 16303 | 49964634 |
C-reactive protein abnormal | 95.97 | 10.65 | 121 | 624066 | 27688 | 49953249 |
Vertigo | 95.47 | 10.65 | 1019 | 623168 | 50813 | 49930124 |
Product prescribing error | 95.06 | 10.65 | 510 | 623677 | 20451 | 49960486 |
Hip arthroplasty | 86.88 | 10.65 | 151 | 624036 | 30278 | 49950659 |
Hepatic function abnormal | 84.65 | 10.65 | 172 | 624015 | 32509 | 49948428 |
Transplant rejection | 83.81 | 10.65 | 10 | 624177 | 9599 | 49971338 |
Cytomegalovirus infection | 83.19 | 10.65 | 60 | 624127 | 17902 | 49963035 |
Vision blurred | 83.09 | 10.65 | 1398 | 622789 | 77249 | 49903688 |
Orthostatic hypotension | 82.14 | 10.65 | 634 | 623553 | 28847 | 49952090 |
Syncope | 81.05 | 10.65 | 1750 | 622437 | 101252 | 49879685 |
Dysgeusia | 80.72 | 10.65 | 784 | 623403 | 38132 | 49942805 |
Pyrexia | 80.27 | 10.65 | 3852 | 620335 | 376351 | 49604586 |
Death | 80.09 | 10.65 | 3241 | 620946 | 322138 | 49658799 |
Product complaint | 79.50 | 10.65 | 316 | 623871 | 11150 | 49969787 |
Drug tolerance decreased | 74.08 | 10.65 | 12 | 624175 | 9148 | 49971789 |
Nasopharyngitis | 73.28 | 10.65 | 1815 | 622372 | 191112 | 49789825 |
Thyroid cancer | 73.05 | 10.65 | 160 | 624027 | 4009 | 49976928 |
Disturbance in attention | 72.59 | 10.65 | 644 | 623543 | 30542 | 49950395 |
Condition aggravated | 71.99 | 10.65 | 2964 | 621223 | 294094 | 49686843 |
Product quality issue | 71.20 | 10.65 | 636 | 623551 | 30222 | 49950715 |
Myelosuppression | 71.08 | 10.65 | 39 | 624148 | 13478 | 49967459 |
Therapeutic product effect incomplete | 69.85 | 10.65 | 756 | 623431 | 90759 | 49890178 |
Product formulation issue | 69.44 | 10.65 | 56 | 624131 | 489 | 49980448 |
Blood calcium decreased | 67.28 | 10.65 | 462 | 623725 | 20244 | 49960693 |
Intentional product use issue | 66.36 | 10.65 | 617 | 623570 | 76301 | 49904636 |
Adrenocortical insufficiency acute | 65.66 | 10.65 | 85 | 624102 | 1359 | 49979578 |
Psoriasis | 65.54 | 10.65 | 1206 | 622981 | 67794 | 49913143 |
Dysphagia | 64.86 | 10.65 | 1329 | 622858 | 76189 | 49904748 |
Tremor | 64.15 | 10.65 | 1864 | 622323 | 113039 | 49867898 |
Oedema peripheral | 63.35 | 10.65 | 2465 | 621722 | 155496 | 49825441 |
Therapeutic response unexpected | 62.76 | 10.65 | 373 | 623814 | 15542 | 49965395 |
Therapy non-responder | 62.33 | 10.65 | 371 | 623816 | 50651 | 49930286 |
Cognitive disorder | 61.67 | 10.65 | 823 | 623364 | 43300 | 49937637 |
Bone marrow failure | 60.57 | 10.65 | 159 | 624028 | 27465 | 49953472 |
Knee arthroplasty | 60.56 | 10.65 | 232 | 623955 | 35614 | 49945323 |
Sedation complication | 59.51 | 10.65 | 240 | 623947 | 8526 | 49972411 |
Pregnancy | 58.40 | 10.65 | 179 | 624008 | 29398 | 49951539 |
Cardio-respiratory arrest | 57.63 | 10.65 | 408 | 623779 | 53484 | 49927453 |
Autoimmune thyroiditis | 57.47 | 10.65 | 126 | 624061 | 3159 | 49977778 |
Dry mouth | 56.93 | 10.65 | 992 | 623195 | 55186 | 49925751 |
Craniopharyngioma | 56.90 | 10.65 | 31 | 624156 | 126 | 49980811 |
Creatinine renal clearance decreased | 56.56 | 10.65 | 293 | 623894 | 11588 | 49969349 |
Neutropenia | 55.08 | 10.65 | 1396 | 622791 | 146569 | 49834368 |
Dehydration | 54.02 | 10.65 | 2348 | 621839 | 150101 | 49830836 |
Nausea | 53.61 | 10.65 | 9677 | 614510 | 695721 | 49285216 |
Insulin-like growth factor increased | 53.53 | 10.65 | 58 | 624129 | 760 | 49980177 |
Panniculitis | 53.43 | 10.65 | 19 | 624168 | 8484 | 49972453 |
Dry skin | 53.27 | 10.65 | 788 | 623399 | 42403 | 49938534 |
Transient ischaemic attack | 53.26 | 10.65 | 620 | 623567 | 31590 | 49949347 |
Reaction to excipient | 52.21 | 10.65 | 68 | 624119 | 1094 | 49979843 |
Sinusitis | 51.84 | 10.65 | 1655 | 622532 | 168903 | 49812034 |
Hyperhidrosis | 51.37 | 10.65 | 1456 | 622731 | 87970 | 49892967 |
Weight decreased | 50.28 | 10.65 | 3268 | 620919 | 217977 | 49762960 |
Nervousness | 50.15 | 10.65 | 542 | 623645 | 27109 | 49953828 |
Rheumatoid nodule | 49.85 | 10.65 | 50 | 624137 | 12685 | 49968252 |
Haemophagocytic lymphohistiocytosis | 49.80 | 10.65 | 22 | 624165 | 8611 | 49972326 |
Visual impairment | 48.36 | 10.65 | 1143 | 623044 | 67132 | 49913805 |
Malaise | 47.94 | 10.65 | 4782 | 619405 | 330750 | 49650187 |
Therapeutic drug monitoring analysis not performed | 47.92 | 10.65 | 51 | 624136 | 654 | 49980283 |
Hot flush | 47.31 | 10.65 | 787 | 623400 | 43382 | 49937555 |
Insomnia | 46.48 | 10.65 | 2619 | 621568 | 172246 | 49808691 |
Anxiety | 46.04 | 10.65 | 2654 | 621533 | 174952 | 49805985 |
Neurotoxicity | 45.97 | 10.65 | 69 | 624118 | 14671 | 49966266 |
Peripheral swelling | 45.83 | 10.65 | 2074 | 622113 | 203862 | 49777075 |
Muscular weakness | 45.51 | 10.65 | 1513 | 622674 | 93500 | 49887437 |
Enthesopathy | 45.32 | 10.65 | 16 | 624171 | 7177 | 49973760 |
Product monitoring error | 44.98 | 10.65 | 103 | 624084 | 2661 | 49978276 |
Thyroidectomy | 44.86 | 10.65 | 58 | 624129 | 926 | 49980011 |
Myxoedema coma | 44.59 | 10.65 | 38 | 624149 | 361 | 49980576 |
Blood parathyroid hormone decreased | 44.52 | 10.65 | 16 | 624171 | 7098 | 49973839 |
Device difficult to use | 44.52 | 10.65 | 34 | 624153 | 9852 | 49971085 |
Mucosal inflammation | 43.85 | 10.65 | 302 | 623885 | 39840 | 49941097 |
Headache | 43.68 | 10.65 | 6997 | 617190 | 499538 | 49481399 |
Hypoglycaemia | 43.30 | 10.65 | 914 | 623273 | 52667 | 49928270 |
Transplant dysfunction | 43.10 | 10.65 | 4 | 624183 | 4680 | 49976257 |
Infective pulmonary exacerbation of cystic fibrosis | 42.79 | 10.65 | 22 | 624165 | 7887 | 49973050 |
Flatulence | 42.64 | 10.65 | 553 | 623634 | 28905 | 49952032 |
Thyroxine free increased | 42.59 | 10.65 | 51 | 624136 | 750 | 49980187 |
Arrhythmia | 42.24 | 10.65 | 608 | 623579 | 32524 | 49948413 |
Device expulsion | 42.23 | 10.65 | 197 | 623990 | 28625 | 49952312 |
Disease progression | 41.96 | 10.65 | 882 | 623305 | 94984 | 49885953 |
Blood pressure increased | 41.01 | 10.65 | 2022 | 622165 | 131110 | 49849827 |
Multiple organ dysfunction syndrome | 40.77 | 10.65 | 410 | 623777 | 49927 | 49931010 |
Toxic epidermal necrolysis | 40.76 | 10.65 | 128 | 624059 | 20864 | 49960073 |
Pathogen resistance | 40.69 | 10.65 | 10 | 624177 | 5679 | 49975258 |
Tri-iodothyronine decreased | 40.36 | 10.65 | 23 | 624164 | 104 | 49980833 |
Oral pain | 40.13 | 10.65 | 479 | 623708 | 24554 | 49956383 |
Cerebral haematoma | 39.95 | 10.65 | 108 | 624079 | 3103 | 49977834 |
Hepatotoxicity | 39.94 | 10.65 | 186 | 624001 | 27040 | 49953897 |
Haematotoxicity | 39.77 | 10.65 | 24 | 624163 | 7871 | 49973066 |
Amnesia | 39.55 | 10.65 | 737 | 623450 | 41523 | 49939414 |
Therapeutic response decreased | 39.39 | 10.65 | 382 | 623805 | 46849 | 49934088 |
Swollen tongue | 39.17 | 10.65 | 532 | 623655 | 28098 | 49952839 |
Respiratory arrest | 38.91 | 10.65 | 214 | 623973 | 29795 | 49951142 |
Diarrhoea | 38.68 | 10.65 | 8016 | 616171 | 580460 | 49400477 |
Accidental exposure to product | 38.45 | 10.65 | 150 | 624037 | 22907 | 49958030 |
Product solubility abnormal | 38.45 | 10.65 | 47 | 624140 | 707 | 49980230 |
Thyroxine increased | 38.21 | 10.65 | 41 | 624146 | 531 | 49980406 |
Gait disturbance | 37.80 | 10.65 | 2236 | 621951 | 147769 | 49833168 |
Blood glucose increased | 36.81 | 10.65 | 1146 | 623041 | 70178 | 49910759 |
Schizoaffective disorder | 36.78 | 10.65 | 83 | 624104 | 2123 | 49978814 |
Myxoedema | 36.77 | 10.65 | 20 | 624167 | 81 | 49980856 |
Anaphylactic reaction | 36.41 | 10.65 | 459 | 623728 | 53596 | 49927341 |
Cardiac arrest | 35.91 | 10.65 | 772 | 623415 | 82879 | 49898058 |
Venoocclusive liver disease | 35.80 | 10.65 | 5 | 624182 | 4256 | 49976681 |
Sensitisation | 35.17 | 10.65 | 67 | 624120 | 1515 | 49979422 |
Diffuse alopecia | 35.11 | 10.65 | 40 | 624147 | 556 | 49980381 |
Live birth | 34.79 | 10.65 | 96 | 624091 | 16312 | 49964625 |
Dysphonia | 34.59 | 10.65 | 673 | 623514 | 38219 | 49942718 |
Pulmonary malformation | 34.59 | 10.65 | 25 | 624162 | 182 | 49980755 |
C-reactive protein increased | 34.50 | 10.65 | 594 | 623593 | 65880 | 49915057 |
Joint destruction | 34.34 | 10.65 | 4 | 624183 | 3912 | 49977025 |
Exophthalmos | 34.26 | 10.65 | 58 | 624129 | 1192 | 49979745 |
Device adhesion issue | 33.99 | 10.65 | 4 | 624183 | 3881 | 49977056 |
Septic shock | 33.65 | 10.65 | 499 | 623688 | 56676 | 49924261 |
Pituitary tumour recurrent | 33.63 | 10.65 | 17 | 624170 | 57 | 49980880 |
Depression | 33.59 | 10.65 | 2421 | 621766 | 163002 | 49817935 |
Hypersomnia | 33.48 | 10.65 | 312 | 623875 | 15002 | 49965935 |
Red blood cell sedimentation rate | 33.16 | 10.65 | 3 | 624184 | 3583 | 49977354 |
Post transplant lymphoproliferative disorder | 32.92 | 10.65 | 6 | 624181 | 4198 | 49976739 |
Overdose | 32.90 | 10.65 | 957 | 623230 | 98770 | 49882167 |
Blood thyroid stimulating hormone | 32.77 | 10.65 | 11 | 624176 | 6 | 49980931 |
Unintentional medical device removal | 32.72 | 10.65 | 13 | 624174 | 5422 | 49975515 |
Sickle cell anaemia with crisis | 32.47 | 10.65 | 8 | 624179 | 4535 | 49976402 |
Gastrooesophageal reflux disease | 32.11 | 10.65 | 1199 | 622988 | 75229 | 49905708 |
Abortion spontaneous | 31.89 | 10.65 | 345 | 623842 | 41427 | 49939510 |
Thyroid hormones increased | 31.34 | 10.65 | 28 | 624159 | 285 | 49980652 |
Thyroxine abnormal | 30.67 | 10.65 | 9 | 624178 | 0 | 49980937 |
Milk-alkali syndrome | 30.64 | 10.65 | 40 | 624147 | 645 | 49980292 |
Product administration error | 30.29 | 10.65 | 374 | 623813 | 19325 | 49961612 |
Multiple-drug resistance | 30.04 | 10.65 | 3 | 624184 | 3311 | 49977626 |
Bone erosion | 29.85 | 10.65 | 62 | 624125 | 11625 | 49969312 |
Urinary tract infection | 29.83 | 10.65 | 3178 | 621009 | 220842 | 49760095 |
Hypoacusis | 29.63 | 10.65 | 387 | 623800 | 20260 | 49960677 |
Product measured potency issue | 29.59 | 10.65 | 18 | 624169 | 94 | 49980843 |
Memory impairment | 29.59 | 10.65 | 1229 | 622958 | 78131 | 49902806 |
Lactose intolerance | 29.56 | 10.65 | 84 | 624103 | 2486 | 49978451 |
Product taste abnormal | 29.48 | 10.65 | 66 | 624121 | 1679 | 49979258 |
Neutrophil count decreased | 29.46 | 10.65 | 395 | 623792 | 45631 | 49935306 |
Jaw disorder | 29.40 | 10.65 | 130 | 624057 | 4813 | 49976124 |
Angina pectoris | 28.92 | 10.65 | 469 | 623718 | 25719 | 49955218 |
Tenosynovitis | 28.75 | 10.65 | 54 | 624133 | 10511 | 49970426 |
Haematochezia | 28.64 | 10.65 | 669 | 623518 | 39213 | 49941724 |
Thrombotic microangiopathy | 28.55 | 10.65 | 40 | 624147 | 8751 | 49972186 |
Papillary thyroid cancer | 28.38 | 10.65 | 71 | 624116 | 1944 | 49978993 |
Eye irritation | 28.37 | 10.65 | 330 | 623857 | 16810 | 49964127 |
Product colour issue | 28.26 | 10.65 | 35 | 624152 | 534 | 49980403 |
Suicide attempt | 28.24 | 10.65 | 458 | 623729 | 51274 | 49929663 |
Papillitis | 28.21 | 10.65 | 11 | 624176 | 15 | 49980922 |
Ageusia | 27.89 | 10.65 | 241 | 623946 | 11342 | 49969595 |
Bone pain | 27.67 | 10.65 | 771 | 623416 | 46458 | 49934479 |
Stillbirth | 27.41 | 10.65 | 20 | 624167 | 5932 | 49975005 |
Full blood count abnormal | 27.40 | 10.65 | 423 | 623764 | 22965 | 49957972 |
Coma | 27.38 | 10.65 | 515 | 623672 | 56364 | 49924573 |
Decreased appetite | 27.26 | 10.65 | 2854 | 621333 | 198069 | 49782868 |
Abdominal distension | 27.18 | 10.65 | 1129 | 623058 | 71774 | 49909163 |
Adverse event | 27.14 | 10.65 | 378 | 623809 | 43385 | 49937552 |
Premature baby | 27.06 | 10.65 | 125 | 624062 | 18212 | 49962725 |
Fatigue | 26.90 | 10.65 | 9417 | 614770 | 698184 | 49282753 |
Inner ear disorder | 26.88 | 10.65 | 31 | 624156 | 437 | 49980500 |
Premature labour | 26.75 | 10.65 | 64 | 624123 | 11412 | 49969525 |
Disorientation | 26.65 | 10.65 | 599 | 623588 | 34885 | 49946052 |
Incorrect dose administered | 26.61 | 10.65 | 784 | 623403 | 47630 | 49933307 |
Trichorrhexis | 26.54 | 10.65 | 49 | 624138 | 1081 | 49979856 |
Respiratory disorder | 26.53 | 10.65 | 251 | 623936 | 30936 | 49950001 |
Malabsorption | 26.39 | 10.65 | 103 | 624084 | 3603 | 49977334 |
Deep vein thrombosis | 26.38 | 10.65 | 1131 | 623056 | 72173 | 49908764 |
Gestational diabetes | 26.32 | 10.65 | 170 | 624017 | 7295 | 49973642 |
Atrioventricular block | 26.30 | 10.65 | 153 | 624034 | 6325 | 49974612 |
Bradycardia | 26.17 | 10.65 | 1007 | 623180 | 63419 | 49917518 |
Disability | 26.16 | 10.65 | 76 | 624111 | 12699 | 49968238 |
Cardiac disorder | 26.14 | 10.65 | 705 | 623482 | 42274 | 49938663 |
Pneumocystis jirovecii pneumonia | 26.01 | 10.65 | 93 | 624094 | 14570 | 49966367 |
Adenovirus infection | 25.96 | 10.65 | 4 | 624183 | 3164 | 49977773 |
Eye swelling | 25.81 | 10.65 | 370 | 623817 | 19774 | 49961163 |
Liver function test abnormal | 25.75 | 10.65 | 723 | 623464 | 43616 | 49937321 |
Product odour abnormal | 25.67 | 10.65 | 47 | 624140 | 1030 | 49979907 |
Systemic infection | 25.66 | 10.65 | 74 | 624113 | 2209 | 49978728 |
Autoimmune hepatitis | 25.16 | 10.65 | 169 | 624018 | 7350 | 49973587 |
Body height decreased | 25.05 | 10.65 | 192 | 623995 | 8716 | 49972221 |
Impaired driving ability | 24.96 | 10.65 | 106 | 624081 | 3855 | 49977082 |
Hypertension | 24.95 | 10.65 | 2973 | 621214 | 208230 | 49772707 |
Hyperkalaemia | 24.89 | 10.65 | 773 | 623414 | 47316 | 49933621 |
Pain in extremity | 24.78 | 10.65 | 3781 | 620406 | 269084 | 49711853 |
Congenital absence of vertebra | 24.70 | 10.65 | 12 | 624175 | 36 | 49980901 |
Epstein-Barr virus infection | 24.61 | 10.65 | 30 | 624157 | 6967 | 49973970 |
Thyroid cancer recurrent | 24.46 | 10.65 | 11 | 624176 | 26 | 49980911 |
Soft tissue disorder | 24.44 | 10.65 | 110 | 624077 | 4104 | 49976833 |
Head discomfort | 24.34 | 10.65 | 225 | 623962 | 10794 | 49970143 |
Scleral discolouration | 24.27 | 10.65 | 26 | 624161 | 336 | 49980601 |
Muscle spasticity | 24.27 | 10.65 | 119 | 624068 | 17065 | 49963872 |
Hip fracture | 24.18 | 10.65 | 452 | 623735 | 25479 | 49955458 |
Foreign body in reproductive tract | 24.16 | 10.65 | 30 | 624157 | 459 | 49980478 |
Dyspepsia | 23.98 | 10.65 | 1131 | 623056 | 72966 | 49907971 |
Renal dysplasia | 23.97 | 10.65 | 18 | 624169 | 140 | 49980797 |
Feeling cold | 23.94 | 10.65 | 356 | 623831 | 19175 | 49961762 |
Presbyacusis | 23.94 | 10.65 | 3 | 624184 | 2773 | 49978164 |
Therapeutic product effect increased | 23.79 | 10.65 | 44 | 624143 | 972 | 49979965 |
Thyroid hormones decreased | 23.72 | 10.65 | 22 | 624165 | 236 | 49980701 |
Somatic delusion | 23.70 | 10.65 | 32 | 624155 | 534 | 49980403 |
Endocrine ophthalmopathy | 23.63 | 10.65 | 26 | 624161 | 347 | 49980590 |
Product physical issue | 23.59 | 10.65 | 111 | 624076 | 4221 | 49976716 |
Insulin-like growth factor decreased | 23.57 | 10.65 | 26 | 624161 | 348 | 49980589 |
Pancreatic neuroendocrine tumour | 23.51 | 10.65 | 23 | 624164 | 265 | 49980672 |
Disseminated intravascular coagulation | 23.43 | 10.65 | 120 | 624067 | 17015 | 49963922 |
Paraesthesia | 23.24 | 10.65 | 1753 | 622434 | 118490 | 49862447 |
Chest pain | 23.07 | 10.65 | 2506 | 621681 | 174376 | 49806561 |
Low turnover osteopathy | 22.98 | 10.65 | 104 | 624083 | 3890 | 49977047 |
Pulmonary tuberculosis | 22.95 | 10.65 | 12 | 624175 | 4261 | 49976676 |
Skin haemorrhage | 22.85 | 10.65 | 155 | 624032 | 6763 | 49974174 |
Cytomegalovirus viraemia | 22.78 | 10.65 | 15 | 624172 | 4694 | 49976243 |
Acute kidney injury | 22.71 | 10.65 | 3177 | 621010 | 224881 | 49756056 |
Listless | 22.68 | 10.65 | 73 | 624114 | 2317 | 49978620 |
Thyroxine decreased | 22.62 | 10.65 | 29 | 624158 | 459 | 49980478 |
Dementia | 22.60 | 10.65 | 299 | 623888 | 15698 | 49965239 |
Pneumonia viral | 22.51 | 10.65 | 153 | 624034 | 6681 | 49974256 |
Lung cyst | 22.43 | 10.65 | 18 | 624169 | 156 | 49980781 |
Thyroxine free decreased | 22.34 | 10.65 | 30 | 624157 | 498 | 49980439 |
Intentional self-injury | 22.32 | 10.65 | 180 | 624007 | 22932 | 49958005 |
Swelling face | 22.30 | 10.65 | 826 | 623361 | 51769 | 49929168 |
International normalised ratio increased | 22.16 | 10.65 | 693 | 623494 | 42459 | 49938478 |
Extremity contracture | 21.98 | 10.65 | 48 | 624139 | 1200 | 49979737 |
Cytokine release syndrome | 21.88 | 10.65 | 46 | 624141 | 8588 | 49972349 |
Injection site reaction | 21.68 | 10.65 | 461 | 623726 | 49571 | 49931366 |
Thyrotoxic periodic paralysis | 21.67 | 10.65 | 9 | 624178 | 16 | 49980921 |
Choking | 21.62 | 10.65 | 179 | 624008 | 8319 | 49972618 |
Blood glucose decreased | 21.57 | 10.65 | 330 | 623857 | 17881 | 49963056 |
Sedation | 21.53 | 10.65 | 512 | 623675 | 30098 | 49950839 |
Body temperature increased | 21.52 | 10.65 | 265 | 623922 | 31076 | 49949861 |
Gastritis | 21.49 | 10.65 | 546 | 623641 | 32437 | 49948500 |
Tinnitus | 21.48 | 10.65 | 476 | 623711 | 27656 | 49953281 |
Graft versus host disease in skin | 21.47 | 10.65 | 3 | 624184 | 2553 | 49978384 |
Chest discomfort | 21.45 | 10.65 | 1372 | 622815 | 91350 | 49889587 |
Haemorrhoids | 21.33 | 10.65 | 342 | 623845 | 18711 | 49962226 |
Reversible airways obstruction | 21.21 | 10.65 | 42 | 624145 | 978 | 49979959 |
Abortion induced | 21.08 | 10.65 | 53 | 624134 | 9291 | 49971646 |
Haematoma | 21.06 | 10.65 | 509 | 623678 | 30001 | 49950936 |
Rapid eye movement sleep behaviour disorder | 21.04 | 10.65 | 18 | 624169 | 172 | 49980765 |
Oral discomfort | 21.00 | 10.65 | 170 | 624017 | 7847 | 49973090 |
Recalled product | 20.90 | 10.65 | 49 | 624138 | 1286 | 49979651 |
Pulmonary embolism | 20.89 | 10.65 | 1490 | 622697 | 100214 | 49880723 |
Drug level changed | 20.59 | 10.65 | 17 | 624170 | 154 | 49980783 |
Chronic graft versus host disease | 20.58 | 10.65 | 5 | 624182 | 2862 | 49978075 |
Injection site swelling | 20.49 | 10.65 | 377 | 623810 | 41396 | 49939541 |
Psoriatic arthropathy | 20.49 | 10.65 | 433 | 623754 | 46599 | 49934338 |
Tongue discomfort | 20.47 | 10.65 | 60 | 624127 | 1808 | 49979129 |
Therapeutic product effect variable | 20.44 | 10.65 | 43 | 624144 | 1047 | 49979890 |
Tooth fracture | 20.29 | 10.65 | 195 | 623992 | 9456 | 49971481 |
Pituitary tumour benign | 20.28 | 10.65 | 58 | 624129 | 1723 | 49979214 |
Acute graft versus host disease in skin | 20.28 | 10.65 | 6 | 624181 | 3012 | 49977925 |
Ventricular hypertrophy | 20.23 | 10.65 | 86 | 624101 | 3129 | 49977808 |
Diverticulum | 20.16 | 10.65 | 210 | 623977 | 10404 | 49970533 |
Coronary artery occlusion | 20.15 | 10.65 | 160 | 624027 | 7343 | 49973594 |
Congenital renal cyst | 20.14 | 10.65 | 7 | 624180 | 5 | 49980932 |
Substance abuse | 20.13 | 10.65 | 13 | 624174 | 4111 | 49976826 |
Sepsis | 20.09 | 10.65 | 1390 | 622797 | 131535 | 49849402 |
Pelvic fracture | 20.06 | 10.65 | 224 | 623963 | 11296 | 49969641 |
Exposure to toxic agent | 20.05 | 10.65 | 10 | 624177 | 3648 | 49977289 |
Small for dates baby | 19.96 | 10.65 | 91 | 624096 | 3414 | 49977523 |
Gastrointestinal motility disorder | 19.96 | 10.65 | 109 | 624078 | 4400 | 49976537 |
Blood iron abnormal | 19.95 | 10.65 | 8 | 624179 | 3318 | 49977619 |
Blood loss anaemia | 19.94 | 10.65 | 170 | 624017 | 7969 | 49972968 |
Renal disorder | 19.94 | 10.65 | 462 | 623725 | 27043 | 49953894 |
Gastrointestinal toxicity | 19.92 | 10.65 | 17 | 624170 | 4660 | 49976277 |
Adenomatous polyposis coli | 19.90 | 10.65 | 10 | 624177 | 33 | 49980904 |
Metastatic renal cell carcinoma | 19.82 | 10.65 | 35 | 624152 | 745 | 49980192 |
Blood creatine abnormal | 19.69 | 10.65 | 14 | 624173 | 99 | 49980838 |
Dry eye | 19.67 | 10.65 | 527 | 623660 | 31568 | 49949369 |
Influenza like illness | 19.66 | 10.65 | 882 | 623305 | 56577 | 49924360 |
Hypophysitis | 19.64 | 10.65 | 53 | 624134 | 1521 | 49979416 |
Hyperlipidaemia | 19.60 | 10.65 | 314 | 623873 | 17176 | 49963761 |
Disease recurrence | 19.57 | 10.65 | 156 | 624031 | 19925 | 49961012 |
Foetal death | 19.56 | 10.65 | 45 | 624142 | 8135 | 49972802 |
Vitamin D deficiency | 19.53 | 10.65 | 221 | 623966 | 11181 | 49969756 |
Skin ulcer | 19.50 | 10.65 | 312 | 623875 | 35006 | 49945931 |
Thyrotoxic crisis | 19.44 | 10.65 | 34 | 624153 | 718 | 49980219 |
Metastases to bone | 19.35 | 10.65 | 136 | 624051 | 17859 | 49963078 |
Lip swelling | 19.35 | 10.65 | 420 | 623767 | 24316 | 49956621 |
Neuromyopathy | 19.28 | 10.65 | 29 | 624158 | 537 | 49980400 |
Blood insulin increased | 19.25 | 10.65 | 15 | 624172 | 124 | 49980813 |
Rhinitis allergic | 19.04 | 10.65 | 153 | 624034 | 7047 | 49973890 |
Pollakiuria | 18.98 | 10.65 | 406 | 623781 | 23445 | 49957492 |
Product dispensing error | 18.86 | 10.65 | 180 | 624007 | 8711 | 49972226 |
Eye pain | 18.85 | 10.65 | 472 | 623715 | 27977 | 49952960 |
Subdural hygroma | 18.76 | 10.65 | 19 | 624168 | 229 | 49980708 |
Ejection fraction | 18.74 | 10.65 | 44 | 624143 | 1156 | 49979781 |
Cardiac pacemaker insertion | 18.73 | 10.65 | 92 | 624095 | 3561 | 49977376 |
Cataract | 18.66 | 10.65 | 737 | 623450 | 46563 | 49934374 |
Intervertebral disc protrusion | 18.51 | 10.65 | 354 | 623833 | 20039 | 49960898 |
Paradoxical drug reaction | 18.49 | 10.65 | 11 | 624176 | 3636 | 49977301 |
Pharyngitis | 18.47 | 10.65 | 133 | 624054 | 17370 | 49963567 |
Ecchymosis | 18.29 | 10.65 | 199 | 623988 | 9970 | 49970967 |
Glomerular filtration rate decreased | 18.25 | 10.65 | 222 | 623965 | 11430 | 49969507 |
Cardiotoxicity | 18.18 | 10.65 | 37 | 624150 | 6990 | 49973947 |
Graft versus host disease | 18.15 | 10.65 | 30 | 624157 | 6136 | 49974801 |
Tenderness | 18.15 | 10.65 | 326 | 623861 | 18239 | 49962698 |
Sprue-like enteropathy | 18.11 | 10.65 | 27 | 624160 | 496 | 49980441 |
Liver injury | 18.09 | 10.65 | 207 | 623980 | 24599 | 49956338 |
Exposure via ingestion | 18.07 | 10.65 | 6 | 624181 | 2797 | 49978140 |
Goitre | 18.06 | 10.65 | 120 | 624067 | 5200 | 49975737 |
Genital swelling | 18.04 | 10.65 | 14 | 624173 | 115 | 49980822 |
Drug eruption | 18 | 10.65 | 195 | 623992 | 23411 | 49957526 |
Frontotemporal dementia | 17.95 | 10.65 | 20 | 624167 | 271 | 49980666 |
Rectal haemorrhage | 17.94 | 10.65 | 612 | 623575 | 37946 | 49942991 |
Arteriosclerosis coronary artery | 17.93 | 10.65 | 158 | 624029 | 7478 | 49973459 |
Skin necrosis | 17.93 | 10.65 | 71 | 624116 | 10796 | 49970141 |
Chromaturia | 17.91 | 10.65 | 266 | 623921 | 14324 | 49966613 |
Arthralgia | 17.89 | 10.65 | 4979 | 619208 | 433723 | 49547214 |
Spinal stenosis | 17.81 | 10.65 | 250 | 623937 | 13300 | 49967637 |
No adverse event | 17.76 | 10.65 | 299 | 623888 | 33279 | 49947658 |
Blood calcium increased | 17.75 | 10.65 | 159 | 624028 | 7560 | 49973377 |
Oropharyngeal swelling | 17.75 | 10.65 | 34 | 624153 | 772 | 49980165 |
Carpal tunnel syndrome | 17.72 | 10.65 | 300 | 623887 | 16593 | 49964344 |
Persistent depressive disorder | 17.71 | 10.65 | 36 | 624151 | 855 | 49980082 |
Therapy partial responder | 17.66 | 10.65 | 34 | 624153 | 6557 | 49974380 |
Polycystic ovaries | 17.66 | 10.65 | 69 | 624118 | 2415 | 49978522 |
Cystitis haemorrhagic | 17.63 | 10.65 | 12 | 624175 | 3690 | 49977247 |
Traumatic ulcer | 17.63 | 10.65 | 9 | 624178 | 31 | 49980906 |
Joint laxity | 17.58 | 10.65 | 4 | 624183 | 2394 | 49978543 |
Inflammation | 17.56 | 10.65 | 551 | 623636 | 56361 | 49924576 |
Hypopituitarism | 17.54 | 10.65 | 36 | 624151 | 861 | 49980076 |
Lymphocyte count decreased | 17.48 | 10.65 | 224 | 623963 | 26083 | 49954854 |
Ankylosing spondylitis | 17.48 | 10.65 | 39 | 624148 | 7126 | 49973811 |
Muscle fatigue | 17.41 | 10.65 | 64 | 624123 | 2175 | 49978762 |
Micturition urgency | 17.38 | 10.65 | 167 | 624020 | 8097 | 49972840 |
Bundle branch block left | 17.36 | 10.65 | 134 | 624053 | 6096 | 49974841 |
Injection site pain | 17.27 | 10.65 | 1158 | 623029 | 109866 | 49871071 |
Broncholithiasis | 17.24 | 10.65 | 15 | 624172 | 147 | 49980790 |
Dystonia | 17.18 | 10.65 | 82 | 624105 | 11844 | 49969093 |
Bronchopulmonary aspergillosis | 17.18 | 10.65 | 43 | 624144 | 7549 | 49973388 |
Device use error | 17.06 | 10.65 | 24 | 624163 | 5242 | 49975695 |
Labelled drug-drug interaction medication error | 17.02 | 10.65 | 201 | 623986 | 10276 | 49970661 |
Hypertensive crisis | 17.01 | 10.65 | 242 | 623945 | 12912 | 49968025 |
Nephropathy toxic | 17.01 | 10.65 | 47 | 624140 | 7982 | 49972955 |
Vessel puncture site haemorrhage | 16.82 | 10.65 | 13 | 624174 | 106 | 49980831 |
Spondylolisthesis | 16.80 | 10.65 | 80 | 624107 | 3057 | 49977880 |
Lymphadenectomy | 16.80 | 10.65 | 36 | 624151 | 888 | 49980049 |
Fear of injection | 16.78 | 10.65 | 31 | 624156 | 6072 | 49974865 |
Insulin autoimmune syndrome | 16.76 | 10.65 | 11 | 624176 | 67 | 49980870 |
Dysstasia | 16.75 | 10.65 | 311 | 623876 | 17508 | 49963429 |
Injection site pruritus | 16.75 | 10.65 | 375 | 623812 | 40036 | 49940901 |
Head injury | 16.66 | 10.65 | 401 | 623786 | 23619 | 49957318 |
Nephritic syndrome | 16.66 | 10.65 | 16 | 624171 | 180 | 49980757 |
Arterial occlusive disease | 16.65 | 10.65 | 109 | 624078 | 4699 | 49976238 |
Abnormal dreams | 16.63 | 10.65 | 183 | 624004 | 9194 | 49971743 |
Arrhythmia neonatal | 16.63 | 10.65 | 9 | 624178 | 36 | 49980901 |
Limb deformity | 16.61 | 10.65 | 13 | 624174 | 3721 | 49977216 |
Cerebrovascular accident | 16.60 | 10.65 | 1370 | 622817 | 93310 | 49887627 |
Supraventricular extrasystoles | 16.57 | 10.65 | 94 | 624093 | 3850 | 49977087 |
Withdrawal syndrome | 16.54 | 10.65 | 307 | 623880 | 17283 | 49963654 |
Tooth dislocation | 16.47 | 10.65 | 8 | 624179 | 24 | 49980913 |
Full blood count decreased | 16.40 | 10.65 | 376 | 623811 | 21970 | 49958967 |
Dilatation atrial | 16.36 | 10.65 | 55 | 624132 | 1786 | 49979151 |
Thyroid cancer metastatic | 16.26 | 10.65 | 13 | 624174 | 112 | 49980825 |
Abnormal weight gain | 16.26 | 10.65 | 47 | 624140 | 1405 | 49979532 |
Neutropenic sepsis | 16.17 | 10.65 | 105 | 624082 | 14042 | 49966895 |
Hiatus hernia | 16.16 | 10.65 | 317 | 623870 | 18027 | 49962910 |
Anaemia postoperative | 16.13 | 10.65 | 60 | 624127 | 2051 | 49978886 |
Piloerection | 16.11 | 10.65 | 20 | 624167 | 306 | 49980631 |
Pneumonia aspiration | 16.10 | 10.65 | 277 | 623910 | 30727 | 49950210 |
Pleural fibrosis | 16.07 | 10.65 | 11 | 624176 | 3373 | 49977564 |
Anosmia | 16.06 | 10.65 | 93 | 624094 | 3838 | 49977099 |
Seronegative arthritis | 16.01 | 10.65 | 3 | 624184 | 2058 | 49978879 |
Speech disorder | 15.98 | 10.65 | 562 | 623625 | 34986 | 49945951 |
Tension | 15.95 | 10.65 | 72 | 624115 | 2690 | 49978247 |
Hair texture abnormal | 15.93 | 10.65 | 88 | 624099 | 3568 | 49977369 |
Ischaemic stroke | 15.93 | 10.65 | 281 | 623906 | 15667 | 49965270 |
Erythema dyschromicum perstans | 15.90 | 10.65 | 10 | 624177 | 56 | 49980881 |
Labile hypertension | 15.86 | 10.65 | 24 | 624163 | 447 | 49980490 |
Cerebellar haematoma | 15.84 | 10.65 | 21 | 624166 | 344 | 49980593 |
Suspected suicide | 15.83 | 10.65 | 26 | 624161 | 5331 | 49975606 |
Acute respiratory distress syndrome | 15.80 | 10.65 | 175 | 624012 | 20924 | 49960013 |
Thinking abnormal | 15.74 | 10.65 | 184 | 624003 | 9383 | 49971554 |
Product residue present | 15.74 | 10.65 | 88 | 624099 | 3584 | 49977353 |
Skin toxicity | 15.74 | 10.65 | 15 | 624172 | 3898 | 49977039 |
Anxiety disorder | 15.73 | 10.65 | 88 | 624099 | 3585 | 49977352 |
Thyroid atrophy | 15.72 | 10.65 | 7 | 624180 | 16 | 49980921 |
Product packaging issue | 15.70 | 10.65 | 36 | 624151 | 931 | 49980006 |
Temperature intolerance | 15.68 | 10.65 | 152 | 624035 | 7387 | 49973550 |
Gallbladder disorder | 15.67 | 10.65 | 292 | 623895 | 16450 | 49964487 |
Aortic intramural haematoma | 15.62 | 10.65 | 10 | 624177 | 58 | 49980879 |
International normalised ratio abnormal | 15.59 | 10.65 | 73 | 624114 | 2770 | 49978167 |
Lymphoproliferative disorder | 15.57 | 10.65 | 8 | 624179 | 2869 | 49978068 |
Incorrect route of product administration | 15.55 | 10.65 | 151 | 624036 | 18515 | 49962422 |
Eructation | 15.52 | 10.65 | 145 | 624042 | 6976 | 49973961 |
Retrograde amnesia | 15.36 | 10.65 | 22 | 624165 | 389 | 49980548 |
Thyroglobulin increased | 15.25 | 10.65 | 9 | 624178 | 44 | 49980893 |
Gastrointestinal tract irritation | 15.17 | 10.65 | 23 | 624164 | 429 | 49980508 |
Feeling jittery | 15.11 | 10.65 | 207 | 623980 | 10953 | 49969984 |
Posterior reversible encephalopathy syndrome | 15.00 | 10.65 | 115 | 624072 | 14813 | 49966124 |
Neck injury | 15 | 10.65 | 51 | 624136 | 1666 | 49979271 |
Temperature regulation disorder | 15.00 | 10.65 | 18 | 624169 | 4209 | 49976728 |
Hair growth abnormal | 14.97 | 10.65 | 67 | 624120 | 2494 | 49978443 |
Blood sodium decreased | 14.96 | 10.65 | 354 | 623833 | 20793 | 49960144 |
Pituitary tumour | 14.93 | 10.65 | 33 | 624154 | 832 | 49980105 |
Magnetic resonance imaging thoracic abnormal | 14.90 | 10.65 | 7 | 624180 | 19 | 49980918 |
Skin abrasion | 14.89 | 10.65 | 160 | 624027 | 7990 | 49972947 |
Poisoning | 14.85 | 10.65 | 91 | 624096 | 12338 | 49968599 |
Lethargy | 14.84 | 10.65 | 749 | 623438 | 48683 | 49932254 |
Premature delivery | 14.81 | 10.65 | 204 | 623983 | 23459 | 49957478 |
Body height below normal | 14.80 | 10.65 | 3 | 624184 | 1946 | 49978991 |
Urinary incontinence | 14.75 | 10.65 | 454 | 623733 | 27754 | 49953183 |
Diabetes mellitus inadequate control | 14.73 | 10.65 | 236 | 623951 | 12909 | 49968028 |
Transcription medication error | 14.73 | 10.65 | 15 | 624172 | 182 | 49980755 |
Graft versus host disease in gastrointestinal tract | 14.66 | 10.65 | 8 | 624179 | 2773 | 49978164 |
Application site erythema | 14.59 | 10.65 | 101 | 624086 | 4437 | 49976500 |
Gingival disorder | 14.54 | 10.65 | 78 | 624109 | 3127 | 49977810 |
Neonatal tachypnoea | 14.51 | 10.65 | 9 | 624178 | 49 | 49980888 |
Gingival pain | 14.48 | 10.65 | 125 | 624062 | 5881 | 49975056 |
Glycosylated haemoglobin increased | 14.47 | 10.65 | 197 | 623990 | 10409 | 49970528 |
Poor quality product administered | 14.46 | 10.65 | 71 | 624116 | 2748 | 49978189 |
Rectourethral fistula | 14.42 | 10.65 | 8 | 624179 | 34 | 49980903 |
General physical health deterioration | 14.38 | 10.65 | 1986 | 622201 | 140448 | 49840489 |
Blood growth hormone increased | 14.33 | 10.65 | 22 | 624165 | 415 | 49980522 |
Aortic valve incompetence | 14.28 | 10.65 | 116 | 624071 | 5360 | 49975577 |
Acute hepatic failure | 14.28 | 10.65 | 124 | 624063 | 15553 | 49965384 |
Hyperchromic anaemia | 14.24 | 10.65 | 8 | 624179 | 35 | 49980902 |
Poisoning deliberate | 14.15 | 10.65 | 50 | 624137 | 7862 | 49973075 |
Diabetic ketoacidosis | 14.15 | 10.65 | 304 | 623883 | 17568 | 49963369 |
Retinitis | 14.13 | 10.65 | 3 | 624184 | 1884 | 49979053 |
Bundle branch block right | 14.13 | 10.65 | 102 | 624085 | 4543 | 49976394 |
Sensation of foreign body | 14.10 | 10.65 | 90 | 624097 | 3846 | 49977091 |
Labyrinthitis | 14.09 | 10.65 | 59 | 624128 | 2132 | 49978805 |
Body height increased | 14.09 | 10.65 | 9 | 624178 | 52 | 49980885 |
Adenoiditis | 14.07 | 10.65 | 8 | 624179 | 36 | 49980901 |
Coombs positive haemolytic anaemia | 13.94 | 10.65 | 19 | 624168 | 320 | 49980617 |
Scar | 13.94 | 10.65 | 214 | 623973 | 11604 | 49969333 |
Hypogammaglobulinaemia | 13.92 | 10.65 | 31 | 624156 | 5668 | 49975269 |
Dyspnoea exertional | 13.91 | 10.65 | 769 | 623418 | 50464 | 49930473 |
Carotid artery stenosis | 13.88 | 10.65 | 103 | 624084 | 4628 | 49976309 |
Oesophageal achalasia | 13.84 | 10.65 | 21 | 624166 | 392 | 49980545 |
Mood altered | 13.82 | 10.65 | 228 | 623959 | 12545 | 49968392 |
Thirst | 13.80 | 10.65 | 196 | 623991 | 10454 | 49970483 |
Blood triglycerides increased | 13.79 | 10.65 | 206 | 623981 | 11106 | 49969831 |
Electrocardiogram abnormal | 13.76 | 10.65 | 149 | 624038 | 7456 | 49973481 |
Anti-thyroid antibody positive | 13.72 | 10.65 | 21 | 624166 | 395 | 49980542 |
Tri-iodothyronine free decreased | 13.71 | 10.65 | 18 | 624169 | 292 | 49980645 |
Retinal artery embolism | 13.69 | 10.65 | 9 | 624178 | 55 | 49980882 |
Amniotic fluid volume increased | 13.69 | 10.65 | 13 | 624174 | 144 | 49980793 |
Aspergillus infection | 13.66 | 10.65 | 41 | 624146 | 6780 | 49974157 |
Mydriasis | 13.66 | 10.65 | 76 | 624111 | 10551 | 49970386 |
Endocrine disorder | 13.65 | 10.65 | 25 | 624162 | 548 | 49980389 |
Optic nerve compression | 13.63 | 10.65 | 4 | 624183 | 0 | 49980937 |
Neonatal thyrotoxicosis | 13.63 | 10.65 | 4 | 624183 | 0 | 49980937 |
Product dose omission issue | 13.61 | 10.65 | 2520 | 621667 | 181318 | 49799619 |
Hypotensive transfusion reaction | 13.58 | 10.65 | 8 | 624179 | 39 | 49980898 |
Tuberculosis | 13.57 | 10.65 | 71 | 624116 | 10012 | 49970925 |
Malignant neoplasm progression | 13.56 | 10.65 | 694 | 623493 | 67430 | 49913507 |
Burning sensation | 13.51 | 10.65 | 688 | 623499 | 44758 | 49936179 |
Injection site erythema | 13.50 | 10.65 | 771 | 623416 | 74165 | 49906772 |
Drug reaction with eosinophilia and systemic symptoms | 13.48 | 10.65 | 258 | 623929 | 28166 | 49952771 |
Nephrectomy | 13.46 | 10.65 | 31 | 624156 | 804 | 49980133 |
X-ray abnormal | 13.45 | 10.65 | 8 | 624179 | 2644 | 49978293 |
Anaemia folate deficiency | 13.43 | 10.65 | 14 | 624173 | 175 | 49980762 |
Vitello-intestinal duct remnant | 13.42 | 10.65 | 8 | 624179 | 40 | 49980897 |
Varicose vein | 13.41 | 10.65 | 95 | 624092 | 4205 | 49976732 |
Urine sodium decreased | 13.41 | 10.65 | 13 | 624174 | 148 | 49980789 |
Hepatojugular reflux | 13.40 | 10.65 | 6 | 624181 | 14 | 49980923 |
Atrioventricular block first degree | 13.38 | 10.65 | 126 | 624061 | 6075 | 49974862 |
Open reduction of fracture | 13.37 | 10.65 | 37 | 624150 | 1078 | 49979859 |
Musculoskeletal disorder | 13.35 | 10.65 | 143 | 624044 | 17206 | 49963731 |
Anaemia vitamin B12 deficiency | 13.35 | 10.65 | 19 | 624168 | 334 | 49980603 |
Impatience | 13.31 | 10.65 | 19 | 624168 | 335 | 49980602 |
Weight loss poor | 13.30 | 10.65 | 33 | 624154 | 899 | 49980038 |
Mucormycosis | 13.30 | 10.65 | 7 | 624180 | 2476 | 49978461 |
Cushingoid | 13.27 | 10.65 | 40 | 624147 | 6605 | 49974332 |
Carcinoid tumour of the stomach | 13.21 | 10.65 | 13 | 624174 | 151 | 49980786 |
Mean cell haemoglobin concentration increased | 13.21 | 10.65 | 22 | 624165 | 446 | 49980491 |
Pancreatitis acute | 13.19 | 10.65 | 386 | 623801 | 23426 | 49957511 |
Anaemia | 13.18 | 10.65 | 3404 | 620783 | 249052 | 49731885 |
Deafness transitory | 13.16 | 10.65 | 3 | 624184 | 1793 | 49979144 |
Hormone level abnormal | 13.15 | 10.65 | 57 | 624130 | 2092 | 49978845 |
Malignant melanoma | 13.08 | 10.65 | 186 | 624001 | 9922 | 49971015 |
Hypocalcaemia | 13.08 | 10.65 | 428 | 623759 | 26388 | 49954549 |
Inappropriate affect | 13.05 | 10.65 | 30 | 624157 | 777 | 49980160 |
Change of bowel habit | 13.04 | 10.65 | 50 | 624137 | 1734 | 49979203 |
Idiosyncratic drug reaction | 13.01 | 10.65 | 28 | 624159 | 693 | 49980244 |
Hepatocellular carcinoma | 12.99 | 10.65 | 54 | 624133 | 1945 | 49978992 |
Hypoglycaemic unconsciousness | 12.98 | 10.65 | 28 | 624159 | 694 | 49980243 |
BK virus infection | 12.86 | 10.65 | 10 | 624177 | 2871 | 49978066 |
Type 2 diabetes mellitus | 12.86 | 10.65 | 324 | 623863 | 34051 | 49946886 |
Decreased bronchial secretion | 12.85 | 10.65 | 9 | 624178 | 62 | 49980875 |
Overgrowth bacterial | 12.85 | 10.65 | 9 | 624178 | 62 | 49980875 |
Juvenile idiopathic arthritis | 12.84 | 10.65 | 10 | 624177 | 2869 | 49978068 |
Product coating issue | 12.83 | 10.65 | 8 | 624179 | 44 | 49980893 |
Anal prolapse | 12.80 | 10.65 | 10 | 624177 | 83 | 49980854 |
Vital capacity decreased | 12.75 | 10.65 | 33 | 624154 | 923 | 49980014 |
Blood pressure orthostatic decreased | 12.73 | 10.65 | 9 | 624178 | 63 | 49980874 |
Petechiae | 12.69 | 10.65 | 221 | 623966 | 12291 | 49968646 |
Granulocytopenia | 12.68 | 10.65 | 109 | 624078 | 5122 | 49975815 |
Immune reconstitution inflammatory syndrome | 12.67 | 10.65 | 31 | 624156 | 5485 | 49975452 |
Hepatitis B reactivation | 12.55 | 10.65 | 5 | 624182 | 2082 | 49978855 |
Hyperglycaemia | 12.49 | 10.65 | 559 | 623628 | 35846 | 49945091 |
Basedow's disease | 12.49 | 10.65 | 17 | 624170 | 286 | 49980651 |
Cardiac failure congestive | 12.49 | 10.65 | 1206 | 622981 | 83176 | 49897761 |
Expired product administered | 12.45 | 10.65 | 111 | 624076 | 5271 | 49975666 |
Bone formation increased | 12.44 | 10.65 | 13 | 624174 | 163 | 49980774 |
Alanine aminotransferase abnormal | 12.44 | 10.65 | 20 | 624167 | 4136 | 49976801 |
Respiratory tract malformation | 12.43 | 10.65 | 10 | 624177 | 87 | 49980850 |
Neovascular age-related macular degeneration | 12.42 | 10.65 | 12 | 624175 | 136 | 49980801 |
Tooth discolouration | 12.41 | 10.65 | 31 | 624156 | 848 | 49980089 |
Lymph node calcification | 12.40 | 10.65 | 15 | 624172 | 223 | 49980714 |
Femur fracture | 12.37 | 10.65 | 573 | 623614 | 36891 | 49944046 |
Faeces discoloured | 12.36 | 10.65 | 273 | 623914 | 15851 | 49965086 |
Melanoma recurrent | 12.34 | 10.65 | 10 | 624177 | 88 | 49980849 |
Ulcer | 12.33 | 10.65 | 175 | 624012 | 20025 | 49960912 |
Immunodeficiency | 12.33 | 10.65 | 120 | 624067 | 14708 | 49966229 |
Electrocardiogram change | 12.32 | 10.65 | 25 | 624162 | 593 | 49980344 |
Atrial septal defect | 12.30 | 10.65 | 126 | 624061 | 6215 | 49974722 |
Gastrointestinal stromal tumour | 12.28 | 10.65 | 32 | 624155 | 899 | 49980038 |
Parathyroid gland enlargement | 12.23 | 10.65 | 7 | 624180 | 32 | 49980905 |
Trance | 12.23 | 10.65 | 7 | 624180 | 32 | 49980905 |
Hydrops foetalis | 12.22 | 10.65 | 18 | 624169 | 327 | 49980610 |
Intramedullary rod insertion | 12.20 | 10.65 | 53 | 624134 | 1947 | 49978990 |
Lung lobectomy | 12.16 | 10.65 | 10 | 624177 | 90 | 49980847 |
Pancreatic neoplasm | 12.16 | 10.65 | 27 | 624160 | 683 | 49980254 |
Congenital acrochordon | 12.16 | 10.65 | 8 | 624179 | 49 | 49980888 |
Drug dependence | 12.13 | 10.65 | 171 | 624016 | 19588 | 49961349 |
Thyroxine free abnormal | 12.12 | 10.65 | 6 | 624181 | 19 | 49980918 |
Retinal dystrophy | 12.12 | 10.65 | 6 | 624181 | 19 | 49980918 |
Kidney transplant rejection | 12.11 | 10.65 | 19 | 624168 | 3968 | 49976969 |
Recalled product administered | 12.09 | 10.65 | 21 | 624166 | 441 | 49980496 |
Blood pressure inadequately controlled | 12.09 | 10.65 | 94 | 624093 | 4286 | 49976651 |
Lupus nephritis | 12.09 | 10.65 | 7 | 624180 | 2348 | 49978589 |
Groin pain | 12.07 | 10.65 | 165 | 624022 | 8726 | 49972211 |
Somnolence | 12.06 | 10.65 | 2130 | 622057 | 152855 | 49828082 |
Lipoma | 12.06 | 10.65 | 55 | 624132 | 2064 | 49978873 |
Agitation neonatal | 12.05 | 10.65 | 22 | 624165 | 481 | 49980456 |
Myositis | 12.02 | 10.65 | 150 | 624037 | 7770 | 49973167 |
Vein discolouration | 12.00 | 10.65 | 14 | 624173 | 200 | 49980737 |
Intervertebral disc degeneration | 11.99 | 10.65 | 233 | 623954 | 13228 | 49967709 |
Thrombosis | 11.98 | 10.65 | 821 | 623366 | 55012 | 49925925 |
Dactylitis | 11.97 | 10.65 | 4 | 624183 | 1857 | 49979080 |
Ophthalmic vein thrombosis | 11.95 | 10.65 | 12 | 624175 | 143 | 49980794 |
Renal cancer metastatic | 11.94 | 10.65 | 16 | 624171 | 265 | 49980672 |
Bladder disorder | 11.94 | 10.65 | 144 | 624043 | 7399 | 49973538 |
Febrile bone marrow aplasia | 11.89 | 10.65 | 39 | 624148 | 6272 | 49974665 |
Lip blister | 11.88 | 10.65 | 52 | 624135 | 1917 | 49979020 |
Abdominal pain upper | 11.81 | 10.65 | 2184 | 622003 | 157125 | 49823812 |
Nocturia | 11.78 | 10.65 | 131 | 624056 | 6599 | 49974338 |
Hypoglycaemia neonatal | 11.76 | 10.65 | 31 | 624156 | 877 | 49980060 |
Disturbance in social behaviour | 11.75 | 10.65 | 11 | 624176 | 2883 | 49978054 |
Arteriosclerosis | 11.74 | 10.65 | 167 | 624020 | 8910 | 49972027 |
Throat clearing | 11.74 | 10.65 | 37 | 624150 | 1161 | 49979776 |
Lymph node palpable | 11.74 | 10.65 | 10 | 624177 | 95 | 49980842 |
Cholelithiasis | 11.73 | 10.65 | 577 | 623610 | 37396 | 49943541 |
Tri-iodothyronine increased | 11.72 | 10.65 | 11 | 624176 | 120 | 49980817 |
Product blister packaging issue | 11.70 | 10.65 | 12 | 624175 | 147 | 49980790 |
Thrombocytopenia | 11.70 | 10.65 | 1387 | 622800 | 126286 | 49854651 |
Adverse drug reaction | 11.68 | 10.65 | 559 | 623628 | 54663 | 49926274 |
Foetal chromosome abnormality | 11.68 | 10.65 | 6 | 624181 | 21 | 49980916 |
Lenticular opacities | 11.67 | 10.65 | 13 | 624174 | 176 | 49980761 |
Aplastic anaemia | 11.67 | 10.65 | 52 | 624135 | 7651 | 49973286 |
Increased tendency to bruise | 11.65 | 10.65 | 171 | 624016 | 9185 | 49971752 |
Mitral valve sclerosis | 11.64 | 10.65 | 11 | 624176 | 121 | 49980816 |
Blood magnesium increased | 11.63 | 10.65 | 11 | 624176 | 2869 | 49978068 |
Retching | 11.58 | 10.65 | 223 | 623964 | 12639 | 49968298 |
Visual acuity reduced | 11.58 | 10.65 | 328 | 623859 | 19811 | 49961126 |
Follicular thyroid cancer | 11.55 | 10.65 | 8 | 624179 | 54 | 49980883 |
Abdominal pain | 11.52 | 10.65 | 3176 | 621011 | 233052 | 49747885 |
Cystic fibrosis | 11.49 | 10.65 | 11 | 624176 | 2853 | 49978084 |
Acute lymphocytic leukaemia recurrent | 11.44 | 10.65 | 5 | 624182 | 1970 | 49978967 |
Fasciotomy | 11.43 | 10.65 | 4 | 624183 | 3 | 49980934 |
Gout | 11.42 | 10.65 | 202 | 623985 | 11268 | 49969669 |
Barrett's oesophagus | 11.42 | 10.65 | 24 | 624163 | 584 | 49980353 |
Sleep apnoea syndrome | 11.39 | 10.65 | 380 | 623807 | 23488 | 49957449 |
Viral mutation identified | 11.39 | 10.65 | 3 | 624184 | 1626 | 49979311 |
Therapeutic response changed | 11.37 | 10.65 | 29 | 624158 | 804 | 49980133 |
Oesophagitis | 11.37 | 10.65 | 230 | 623957 | 13153 | 49967784 |
Status epilepticus | 11.35 | 10.65 | 108 | 624079 | 13298 | 49967639 |
Low density lipoprotein increased | 11.34 | 10.65 | 113 | 624074 | 5533 | 49975404 |
Pulse abnormal | 11.34 | 10.65 | 49 | 624138 | 1796 | 49979141 |
Wrist fracture | 11.33 | 10.65 | 202 | 623985 | 11285 | 49969652 |
Peripheral coldness | 11.29 | 10.65 | 184 | 624003 | 10099 | 49970838 |
Skin exfoliation | 11.29 | 10.65 | 515 | 623672 | 33097 | 49947840 |
Visual field defect | 11.29 | 10.65 | 115 | 624072 | 5664 | 49975273 |
Increased appetite | 11.29 | 10.65 | 155 | 624032 | 8206 | 49972731 |
Orthostatic intolerance | 11.28 | 10.65 | 32 | 624155 | 946 | 49979991 |
Localised infection | 11.28 | 10.65 | 234 | 623953 | 25251 | 49955686 |
Kidney malrotation | 11.28 | 10.65 | 6 | 624181 | 23 | 49980914 |
Spinal osteoarthritis | 11.25 | 10.65 | 240 | 623947 | 13852 | 49967085 |
Maternal exposure timing unspecified | 11.24 | 10.65 | 17 | 624170 | 3603 | 49977334 |
Eating disorder | 11.22 | 10.65 | 259 | 623928 | 15150 | 49965787 |
Device related infection | 11.17 | 10.65 | 184 | 624003 | 20551 | 49960386 |
Pulmonary arterial hypertension | 11.15 | 10.65 | 329 | 623858 | 19990 | 49960947 |
Breast discomfort | 11.11 | 10.65 | 19 | 624168 | 394 | 49980543 |
Congenital hydronephrosis | 11.07 | 10.65 | 19 | 624168 | 395 | 49980542 |
Mucosal haemorrhage | 11.07 | 10.65 | 28 | 624159 | 772 | 49980165 |
Energy increased | 11.04 | 10.65 | 56 | 624131 | 2196 | 49978741 |
Eyelid oedema | 11.01 | 10.65 | 171 | 624016 | 9295 | 49971642 |
Pancreatic enzymes increased | 10.99 | 10.65 | 25 | 624162 | 643 | 49980294 |
Sinus node dysfunction | 10.98 | 10.65 | 85 | 624102 | 3870 | 49977067 |
Application site swelling | 10.96 | 10.65 | 21 | 624166 | 477 | 49980460 |
Deep brain stimulation | 10.90 | 10.65 | 6 | 624181 | 25 | 49980912 |
Shock | 10.88 | 10.65 | 184 | 624003 | 20466 | 49960471 |
Rotator cuff repair | 10.87 | 10.65 | 46 | 624141 | 1670 | 49979267 |
Rib deformity | 10.86 | 10.65 | 12 | 624175 | 161 | 49980776 |
Cold sweat | 10.79 | 10.65 | 188 | 623999 | 10456 | 49970481 |
Starvation ketoacidosis | 10.78 | 10.65 | 8 | 624179 | 61 | 49980876 |
Bone loss | 10.78 | 10.65 | 63 | 624124 | 2609 | 49978328 |
Meniere's disease | 10.76 | 10.65 | 13 | 624174 | 193 | 49980744 |
Gastric pH increased | 10.75 | 10.65 | 7 | 624180 | 42 | 49980895 |
Histamine intolerance | 10.75 | 10.65 | 7 | 624180 | 42 | 49980895 |
Dysuria | 10.75 | 10.65 | 442 | 623745 | 28062 | 49952875 |
Radiotherapy | 10.73 | 10.65 | 16 | 624171 | 294 | 49980643 |
Virologic failure | 10.71 | 10.65 | 3 | 624184 | 1561 | 49979376 |
Product size issue | 10.69 | 10.65 | 16 | 624171 | 295 | 49980642 |
Intentional underdose | 10.69 | 10.65 | 44 | 624143 | 1578 | 49979359 |
Hospitalisation | 10.66 | 10.65 | 708 | 623479 | 67229 | 49913708 |
Sensory level abnormal | 10.66 | 10.65 | 10 | 624177 | 109 | 49980828 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hypothyroidism | 324.77 | 10.19 | 432 | 172504 | 15474 | 29386117 |
Blood thyroid stimulating hormone increased | 279.07 | 10.19 | 192 | 172744 | 2913 | 29398678 |
Drug abuse | 253.55 | 10.19 | 76 | 172860 | 79807 | 29321784 |
Drug ineffective | 184.66 | 10.19 | 1306 | 171630 | 361864 | 29039727 |
Toxicity to various agents | 178.14 | 10.19 | 478 | 172458 | 173183 | 29228408 |
Foetal exposure during pregnancy | 175.52 | 10.19 | 515 | 172421 | 33352 | 29368239 |
Atrial septal defect | 161.56 | 10.19 | 199 | 172737 | 6590 | 29395001 |
Off label use | 135.03 | 10.19 | 1119 | 171817 | 299681 | 29101910 |
Febrile neutropenia | 132.32 | 10.19 | 287 | 172649 | 111953 | 29289638 |
Craniopharyngioma | 123.78 | 10.19 | 51 | 172885 | 242 | 29401349 |
Small for dates baby | 103.60 | 10.19 | 116 | 172820 | 3463 | 29398128 |
Blood thyroid stimulating hormone decreased | 101.09 | 10.19 | 84 | 172852 | 1714 | 29399877 |
Fatigue | 98.57 | 10.19 | 2485 | 170451 | 314336 | 29087255 |
Treatment failure | 87.22 | 10.19 | 54 | 172882 | 36885 | 29364706 |
Asthenia | 79.25 | 10.19 | 1729 | 171207 | 213521 | 29188070 |
Blood thyroid stimulating hormone abnormal | 78.66 | 10.19 | 36 | 172900 | 230 | 29401361 |
Thyroid function test abnormal | 74.22 | 10.19 | 47 | 172889 | 615 | 29400976 |
Pituitary tumour benign | 66.87 | 10.19 | 47 | 172889 | 739 | 29400852 |
Neutropenia | 66.83 | 10.19 | 473 | 172463 | 131238 | 29270353 |
Thyroid disorder | 65.10 | 10.19 | 80 | 172856 | 2642 | 29398949 |
Drug resistance | 62.20 | 10.19 | 24 | 172912 | 21516 | 29380075 |
Drug dependence | 57.95 | 10.19 | 25 | 172911 | 20956 | 29380635 |
Respiratory disorder neonatal | 57.13 | 10.19 | 55 | 172881 | 1370 | 29400221 |
Insulin-like growth factor decreased | 57.09 | 10.19 | 29 | 172907 | 240 | 29401351 |
Large for dates baby | 55.27 | 10.19 | 44 | 172892 | 843 | 29400748 |
Thyroid cancer | 53.54 | 10.19 | 52 | 172884 | 1310 | 29400281 |
Thyroxine free decreased | 52.59 | 10.19 | 27 | 172909 | 229 | 29401362 |
Product use in unapproved indication | 51.18 | 10.19 | 298 | 172638 | 86577 | 29315014 |
Patent ductus arteriosus | 49.08 | 10.19 | 75 | 172861 | 3056 | 29398535 |
Insulin-like growth factor increased | 46.67 | 10.19 | 44 | 172892 | 1067 | 29400524 |
Chronic pigmented purpura | 45.48 | 10.19 | 19 | 172917 | 94 | 29401497 |
Infantile apnoea | 44.95 | 10.19 | 39 | 172897 | 846 | 29400745 |
Hypopituitarism | 44.90 | 10.19 | 53 | 172883 | 1677 | 29399914 |
Hyperthyroidism | 44.66 | 10.19 | 131 | 172805 | 8477 | 29393114 |
Thyroxine decreased | 44.08 | 10.19 | 19 | 172917 | 103 | 29401488 |
Adrenocortical insufficiency acute | 43.83 | 10.19 | 46 | 172890 | 1274 | 29400317 |
Bradycardia neonatal | 42.92 | 10.19 | 39 | 172897 | 901 | 29400690 |
Pyloric stenosis | 40.02 | 10.19 | 34 | 172902 | 716 | 29400875 |
Cytomegalovirus infection | 39.99 | 10.19 | 46 | 172890 | 23169 | 29378422 |
Autoimmune thyroiditis | 39.69 | 10.19 | 39 | 172897 | 997 | 29400594 |
Fall | 37.99 | 10.19 | 1328 | 171608 | 175850 | 29225741 |
Bone marrow failure | 37.69 | 10.19 | 64 | 172872 | 27385 | 29374206 |
Intentional product misuse | 37.27 | 10.19 | 93 | 172843 | 34568 | 29367023 |
Decreased appetite | 35.93 | 10.19 | 1108 | 171828 | 144234 | 29257357 |
Dizziness | 35.42 | 10.19 | 1400 | 171536 | 188284 | 29213307 |
Goitre | 34.90 | 10.19 | 43 | 172893 | 1424 | 29400167 |
Neurotoxicity | 33.61 | 10.19 | 22 | 172914 | 14591 | 29387000 |
Epiphysiolysis | 33.55 | 10.19 | 15 | 172921 | 90 | 29401501 |
Hypophysitis | 33.47 | 10.19 | 49 | 172887 | 1921 | 29399670 |
Tropical infectious disease | 33.35 | 10.19 | 12 | 172924 | 36 | 29401555 |
Suicide attempt | 33.29 | 10.19 | 96 | 172840 | 34014 | 29367577 |
Sepsis | 32.82 | 10.19 | 612 | 172324 | 142070 | 29259521 |
Pituitary tumour recurrent | 32.73 | 10.19 | 13 | 172923 | 55 | 29401536 |
Thyroid hormones decreased | 31.64 | 10.19 | 16 | 172920 | 131 | 29401460 |
Secondary hypogonadism | 31.30 | 10.19 | 20 | 172916 | 266 | 29401325 |
Infusion related reaction | 31.22 | 10.19 | 141 | 172795 | 43745 | 29357846 |
Blood testosterone decreased | 30.96 | 10.19 | 70 | 172866 | 3860 | 29397731 |
Ventricular septal defect | 30.22 | 10.19 | 65 | 172871 | 3464 | 29398127 |
Immune reconstitution inflammatory syndrome | 29.57 | 10.19 | 5 | 172931 | 7797 | 29393794 |
Graft versus host disease | 29.03 | 10.19 | 10 | 172926 | 9618 | 29391973 |
Leukopenia | 28.56 | 10.19 | 197 | 172739 | 55006 | 29346585 |
Macrocephaly | 28.55 | 10.19 | 22 | 172914 | 401 | 29401190 |
Multiple organ dysfunction syndrome | 28.50 | 10.19 | 234 | 172702 | 62882 | 29338709 |
Walking aid user | 28.43 | 10.19 | 39 | 172897 | 1438 | 29400153 |
Overdose | 28.34 | 10.19 | 314 | 172622 | 79505 | 29322086 |
Pneumocystis jirovecii pneumonia | 28.09 | 10.19 | 34 | 172902 | 16745 | 29384846 |
Adrenal insufficiency | 27.97 | 10.19 | 134 | 172802 | 10980 | 29390611 |
Pyrexia | 27.95 | 10.19 | 1386 | 171550 | 286236 | 29115355 |
Potassium wasting nephropathy | 27.30 | 10.19 | 13 | 172923 | 92 | 29401499 |
Diarrhoea | 27.10 | 10.19 | 2277 | 170659 | 330421 | 29071170 |
Diabetes insipidus | 27.06 | 10.19 | 50 | 172886 | 2384 | 29399207 |
Synovitis | 27.00 | 10.19 | 15 | 172921 | 10875 | 29390716 |
Hypospadias | 26.52 | 10.19 | 56 | 172880 | 2946 | 29398645 |
Bronchopulmonary aspergillosis | 26.52 | 10.19 | 20 | 172916 | 12324 | 29389267 |
Substance abuse | 26.51 | 10.19 | 4 | 172932 | 6783 | 29394808 |
Neoplasm recurrence | 26.37 | 10.19 | 44 | 172892 | 1933 | 29399658 |
Toxic epidermal necrolysis | 26.16 | 10.19 | 41 | 172895 | 18112 | 29383479 |
Haematotoxicity | 26.05 | 10.19 | 4 | 172932 | 6695 | 29394896 |
Diabetic foetopathy | 25.75 | 10.19 | 16 | 172920 | 202 | 29401389 |
Electrocardiogram QRS complex abnormal | 25.24 | 10.19 | 18 | 172918 | 290 | 29401301 |
Pathogen resistance | 25.22 | 10.19 | 8 | 172928 | 8108 | 29393483 |
Palmar-plantar erythrodysaesthesia syndrome | 25.09 | 10.19 | 160 | 172776 | 14599 | 29386992 |
Myxoedema coma | 24.98 | 10.19 | 17 | 172919 | 253 | 29401338 |
Dysphonia | 24.96 | 10.19 | 195 | 172741 | 19001 | 29382590 |
Blood thyroid stimulating hormone normal | 24.89 | 10.19 | 6 | 172930 | 0 | 29401591 |
Neonatal behavioural syndrome | 24.86 | 10.19 | 13 | 172923 | 115 | 29401476 |
Thyroxine free increased | 24.65 | 10.19 | 16 | 172920 | 219 | 29401372 |
Poisoning | 24.44 | 10.19 | 14 | 172922 | 9979 | 29391612 |
Drug hypersensitivity | 24.32 | 10.19 | 269 | 172667 | 68137 | 29333454 |
Therapeutic product effect incomplete | 24.11 | 10.19 | 133 | 172803 | 39172 | 29362419 |
Cytomegalovirus viraemia | 24.07 | 10.19 | 4 | 172932 | 6316 | 29395275 |
General physical health deterioration | 24.04 | 10.19 | 779 | 172157 | 102078 | 29299513 |
Pulmonary valve stenosis congenital | 23.85 | 10.19 | 13 | 172923 | 126 | 29401465 |
Tri-iodothyronine decreased | 23.66 | 10.19 | 9 | 172927 | 33 | 29401558 |
Flatulence | 23.64 | 10.19 | 181 | 172755 | 17528 | 29384063 |
Metastatic renal cell carcinoma | 23.62 | 10.19 | 41 | 172895 | 1861 | 29399730 |
Newborn persistent pulmonary hypertension | 23.55 | 10.19 | 12 | 172924 | 100 | 29401491 |
Selective eating disorder | 23.52 | 10.19 | 38 | 172898 | 1625 | 29399966 |
Congenital mitral valve incompetence | 23.06 | 10.19 | 12 | 172924 | 105 | 29401486 |
Septic shock | 23.05 | 10.19 | 244 | 172692 | 62316 | 29339275 |
Aspergillus infection | 22.92 | 10.19 | 17 | 172919 | 10564 | 29391027 |
Weight decreased | 22.83 | 10.19 | 1090 | 171846 | 149815 | 29251776 |
Cerebral atrophy congenital | 22.65 | 10.19 | 10 | 172926 | 58 | 29401533 |
Painful respiration | 22.60 | 10.19 | 31 | 172905 | 1143 | 29400448 |
Dehydration | 22.57 | 10.19 | 852 | 172084 | 113896 | 29287695 |
Papillary thyroid cancer | 22.46 | 10.19 | 22 | 172914 | 560 | 29401031 |
Completed suicide | 22.34 | 10.19 | 382 | 172554 | 89864 | 29311727 |
Contraindicated product administered | 21.24 | 10.19 | 47 | 172889 | 18219 | 29383372 |
Hypoglycaemia neonatal | 21.19 | 10.19 | 37 | 172899 | 1687 | 29399904 |
Granulocytopenia | 21.08 | 10.19 | 80 | 172856 | 5914 | 29395677 |
Aortic aneurysm | 21.04 | 10.19 | 82 | 172854 | 6138 | 29395453 |
Therapy non-responder | 20.99 | 10.19 | 101 | 172835 | 30810 | 29370781 |
Pituitary apoplexy | 20.89 | 10.19 | 8 | 172928 | 30 | 29401561 |
Sedation | 20.89 | 10.19 | 44 | 172892 | 17361 | 29384230 |
Blood thyroid stimulating hormone | 20.74 | 10.19 | 5 | 172931 | 0 | 29401591 |
Neutropenic sepsis | 20.45 | 10.19 | 23 | 172913 | 11704 | 29389887 |
Coeliac disease | 20.44 | 10.19 | 21 | 172915 | 567 | 29401024 |
Intentional self-injury | 20.08 | 10.19 | 26 | 172910 | 12435 | 29389156 |
Growth retardation | 19.97 | 10.19 | 35 | 172901 | 1601 | 29399990 |
Epstein-Barr virus infection | 19.79 | 10.19 | 7 | 172929 | 6622 | 29394969 |
Drug intolerance | 19.78 | 10.19 | 184 | 172752 | 48195 | 29353396 |
Tri-iodothyronine increased | 19.75 | 10.19 | 8 | 172928 | 36 | 29401555 |
C-reactive protein increased | 19.57 | 10.19 | 165 | 172771 | 44098 | 29357493 |
Haemangioma congenital | 19.52 | 10.19 | 19 | 172917 | 480 | 29401111 |
Premature baby | 19.50 | 10.19 | 170 | 172766 | 17110 | 29384481 |
Glossodynia | 19.42 | 10.19 | 52 | 172884 | 3191 | 29398400 |
Hepatic function abnormal | 19.38 | 10.19 | 142 | 172794 | 39117 | 29362474 |
Fractured coccyx | 19.28 | 10.19 | 12 | 172924 | 152 | 29401439 |
Dermatomyositis | 19.17 | 10.19 | 27 | 172909 | 1021 | 29400570 |
Pituitary tumour | 19.07 | 10.19 | 19 | 172917 | 494 | 29401097 |
Dry skin | 18.86 | 10.19 | 214 | 172722 | 23093 | 29378498 |
Neonatal tachypnoea | 18.69 | 10.19 | 12 | 172924 | 161 | 29401430 |
Dependence on oxygen therapy | 18.50 | 10.19 | 12 | 172924 | 164 | 29401427 |
Anencephaly | 18.47 | 10.19 | 11 | 172925 | 128 | 29401463 |
Transplant rejection | 18.45 | 10.19 | 16 | 172920 | 9196 | 29392395 |
Thyroiditis | 18.25 | 10.19 | 37 | 172899 | 1891 | 29399700 |
Conduction disorder | 18.24 | 10.19 | 36 | 172900 | 1804 | 29399787 |
Hyponatraemia | 18.14 | 10.19 | 521 | 172415 | 67112 | 29334479 |
Hyperprolactinaemia | 17.93 | 10.19 | 29 | 172907 | 1241 | 29400350 |
Hypoacusis | 17.92 | 10.19 | 145 | 172791 | 14278 | 29387313 |
Infective pulmonary exacerbation of cystic fibrosis | 17.91 | 10.19 | 7 | 172929 | 6229 | 29395362 |
Neonatal respiratory distress syndrome | 17.90 | 10.19 | 56 | 172880 | 3754 | 29397837 |
Growth hormone deficiency | 17.84 | 10.19 | 13 | 172923 | 217 | 29401374 |
Intentional overdose | 17.77 | 10.19 | 142 | 172794 | 38386 | 29363205 |
Hepatotoxicity | 17.64 | 10.19 | 50 | 172886 | 17817 | 29383774 |
Cortisol decreased | 17.62 | 10.19 | 23 | 172913 | 808 | 29400783 |
Rhythm idioventricular | 17.59 | 10.19 | 14 | 172922 | 268 | 29401323 |
Thyroxine increased | 17.24 | 10.19 | 8 | 172928 | 53 | 29401538 |
Thyroid cancer metastatic | 17.20 | 10.19 | 7 | 172929 | 32 | 29401559 |
Tachyarrhythmia | 17.17 | 10.19 | 47 | 172889 | 2922 | 29398669 |
Cerebrovascular accident | 17.06 | 10.19 | 579 | 172357 | 76332 | 29325259 |
Alanine aminotransferase increased | 17.00 | 10.19 | 302 | 172634 | 70642 | 29330949 |
Drug ineffective for unapproved indication | 17 | 10.19 | 36 | 172900 | 14178 | 29387413 |
Febrile bone marrow aplasia | 17.00 | 10.19 | 11 | 172925 | 7340 | 29394251 |
Anti-thyroid antibody positive | 16.99 | 10.19 | 8 | 172928 | 55 | 29401536 |
Haemophagocytic lymphohistiocytosis | 16.84 | 10.19 | 22 | 172914 | 10482 | 29391109 |
Post procedural hypothyroidism | 16.83 | 10.19 | 5 | 172931 | 6 | 29401585 |
Neonatal respiratory acidosis | 16.76 | 10.19 | 8 | 172928 | 57 | 29401534 |
Tumour lysis syndrome | 16.74 | 10.19 | 35 | 172901 | 13849 | 29387742 |
Anaphylactic shock | 16.61 | 10.19 | 33 | 172903 | 13303 | 29388288 |
Thyroid cancer recurrent | 16.59 | 10.19 | 4 | 172932 | 0 | 29401591 |
Product use issue | 16.47 | 10.19 | 207 | 172729 | 51237 | 29350354 |
Neutrophil count decreased | 16.42 | 10.19 | 169 | 172767 | 43398 | 29358193 |
Thyroid hormones increased | 16.41 | 10.19 | 8 | 172928 | 60 | 29401531 |
Interstitial lung disease | 16.40 | 10.19 | 238 | 172698 | 57480 | 29344111 |
Respiratory depression | 16.38 | 10.19 | 34 | 172902 | 13489 | 29388102 |
Exposure via breast milk | 16.38 | 10.19 | 33 | 172903 | 1679 | 29399912 |
Atrial fibrillation | 16.36 | 10.19 | 765 | 172171 | 104881 | 29296710 |
Constipation | 16.28 | 10.19 | 820 | 172116 | 113340 | 29288251 |
Total lung capacity abnormal | 16.18 | 10.19 | 10 | 172926 | 125 | 29401466 |
Intercapillary glomerulosclerosis | 16.08 | 10.19 | 7 | 172929 | 39 | 29401552 |
Brain natriuretic peptide abnormal | 15.97 | 10.19 | 14 | 172922 | 308 | 29401283 |
Drug reaction with eosinophilia and systemic symptoms | 15.94 | 10.19 | 97 | 172839 | 27895 | 29373696 |
Alveolitis | 15.82 | 10.19 | 31 | 172905 | 1545 | 29400046 |
Diffuse alopecia | 15.64 | 10.19 | 5 | 172931 | 9 | 29401582 |
Acute graft versus host disease in skin | 15.60 | 10.19 | 4 | 172932 | 4660 | 29396931 |
Pulmonary artery stenosis | 15.38 | 10.19 | 12 | 172924 | 223 | 29401368 |
Coagulation disorder neonatal | 15.37 | 10.19 | 6 | 172930 | 24 | 29401567 |
Blood growth hormone increased | 15.25 | 10.19 | 13 | 172923 | 275 | 29401316 |
Pseudomonas infection | 15.17 | 10.19 | 25 | 172911 | 10827 | 29390764 |
Forced vital capacity decreased | 15.12 | 10.19 | 19 | 172917 | 642 | 29400949 |
Urine oxalate increased | 14.99 | 10.19 | 5 | 172931 | 11 | 29401580 |
Hypersomnia | 14.97 | 10.19 | 111 | 172825 | 10643 | 29390948 |
Tongue movement disturbance | 14.90 | 10.19 | 8 | 172928 | 75 | 29401516 |
Tracheal fistula | 14.90 | 10.19 | 8 | 172928 | 75 | 29401516 |
N-terminal prohormone brain natriuretic peptide abnormal | 14.87 | 10.19 | 11 | 172925 | 188 | 29401403 |
Prescribed underdose | 14.87 | 10.19 | 87 | 172849 | 7699 | 29393892 |
Hypertension | 14.70 | 10.19 | 828 | 172108 | 115786 | 29285805 |
Sopor | 14.55 | 10.19 | 26 | 172910 | 10908 | 29390683 |
Pulmonary arterial pressure abnormal | 14.53 | 10.19 | 11 | 172925 | 195 | 29401396 |
Thyroidectomy | 14.53 | 10.19 | 7 | 172929 | 51 | 29401540 |
Adenovirus infection | 14.52 | 10.19 | 4 | 172932 | 4443 | 29397148 |
Mucormycosis | 14.47 | 10.19 | 6 | 172930 | 5152 | 29396439 |
Delirium | 14.37 | 10.19 | 154 | 172782 | 39243 | 29362348 |
Epispadias | 14.35 | 10.19 | 10 | 172926 | 155 | 29401436 |
Chest injury | 14.16 | 10.19 | 28 | 172908 | 1405 | 29400186 |
Shoulder dystocia | 14.15 | 10.19 | 6 | 172930 | 31 | 29401560 |
Product prescribing error | 14.08 | 10.19 | 164 | 172772 | 17812 | 29383779 |
BK virus infection | 14.00 | 10.19 | 5 | 172931 | 4702 | 29396889 |
Anaphylactic reaction | 13.96 | 10.19 | 99 | 172837 | 27474 | 29374117 |
Nephropathy toxic | 13.93 | 10.19 | 26 | 172910 | 10730 | 29390861 |
Tricuspid valve incompetence | 13.65 | 10.19 | 90 | 172846 | 8304 | 29393287 |
Pancytopenia | 13.62 | 10.19 | 376 | 172560 | 82792 | 29318799 |
Blood glucose increased | 13.58 | 10.19 | 446 | 172490 | 58538 | 29343053 |
Foreign body in throat | 13.57 | 10.19 | 7 | 172929 | 60 | 29401531 |
Cytopenia | 13.52 | 10.19 | 23 | 172913 | 9836 | 29391755 |
Lumbar puncture | 13.51 | 10.19 | 8 | 172928 | 92 | 29401499 |
Muscular weakness | 13.47 | 10.19 | 466 | 172470 | 61586 | 29340005 |
Aorticopulmonary septal defect | 13.43 | 10.19 | 5 | 172931 | 17 | 29401574 |
Hypersensitivity | 13.38 | 10.19 | 223 | 172713 | 52680 | 29348911 |
Infection | 13.35 | 10.19 | 344 | 172592 | 76407 | 29325184 |
Oxygen saturation increased | 13.32 | 10.19 | 12 | 172924 | 274 | 29401317 |
Mineral deficiency | 13.29 | 10.19 | 6 | 172930 | 37 | 29401554 |
Medulloblastoma recurrent | 13.28 | 10.19 | 7 | 172929 | 63 | 29401528 |
Osteochondroma | 13.21 | 10.19 | 5 | 172931 | 18 | 29401573 |
Myelosuppression | 12.99 | 10.19 | 33 | 172903 | 12194 | 29389397 |
Mucosal inflammation | 12.98 | 10.19 | 120 | 172816 | 31475 | 29370116 |
Enthesopathy | 12.93 | 10.19 | 3 | 172933 | 3740 | 29397851 |
Ageusia | 12.86 | 10.19 | 93 | 172843 | 8845 | 29392746 |
Urticaria | 12.68 | 10.19 | 234 | 172702 | 54426 | 29347165 |
Chest discomfort | 12.58 | 10.19 | 191 | 172745 | 45792 | 29355799 |
Cardiotoxicity | 12.56 | 10.19 | 6 | 172930 | 4738 | 29396853 |
Lymphocyte count decreased | 12.49 | 10.19 | 64 | 172872 | 19207 | 29382384 |
Fluid replacement | 12.44 | 10.19 | 3 | 172933 | 0 | 29401591 |
Polyglandular autoimmune syndrome type II | 12.44 | 10.19 | 3 | 172933 | 0 | 29401591 |
Tracheal pain | 12.42 | 10.19 | 6 | 172930 | 44 | 29401547 |
Empty sella syndrome | 12.42 | 10.19 | 6 | 172930 | 44 | 29401547 |
Drug interaction | 12.36 | 10.19 | 990 | 171946 | 196395 | 29205196 |
Maternal exposure during breast feeding | 12.30 | 10.19 | 27 | 172909 | 1459 | 29400132 |
Gastrooesophageal cancer | 12.26 | 10.19 | 5 | 172931 | 23 | 29401568 |
Neonatal pneumothorax | 12.24 | 10.19 | 4 | 172932 | 8 | 29401583 |
Brain oedema | 12.21 | 10.19 | 34 | 172902 | 12186 | 29389405 |
Seroma | 12.15 | 10.19 | 16 | 172920 | 567 | 29401024 |
Neonatal respiratory distress | 12.03 | 10.19 | 15 | 172921 | 503 | 29401088 |
Hypotonia neonatal | 11.99 | 10.19 | 24 | 172912 | 1215 | 29400376 |
Retrograde amnesia | 11.93 | 10.19 | 8 | 172928 | 116 | 29401475 |
Application site erythema | 11.91 | 10.19 | 33 | 172903 | 2066 | 29399525 |
Hypernatraemia | 11.90 | 10.19 | 79 | 172857 | 7307 | 29394284 |
Cranial sutures widening | 11.79 | 10.19 | 7 | 172929 | 81 | 29401510 |
Liposarcoma | 11.76 | 10.19 | 8 | 172928 | 119 | 29401472 |
Scapula fracture | 11.64 | 10.19 | 10 | 172926 | 214 | 29401377 |
Malignant melanoma stage IV | 11.61 | 10.19 | 5 | 172931 | 27 | 29401564 |
Urethral valves | 11.49 | 10.19 | 11 | 172925 | 272 | 29401319 |
Ankylosing spondylitis | 11.49 | 10.19 | 5 | 172931 | 4171 | 29397420 |
Serotonin syndrome | 11.44 | 10.19 | 58 | 172878 | 17454 | 29384137 |
Poisoning deliberate | 11.42 | 10.19 | 10 | 172926 | 5721 | 29395870 |
Bronchiectasis | 11.39 | 10.19 | 13 | 172923 | 6572 | 29395019 |
Thyroxine abnormal | 11.37 | 10.19 | 4 | 172932 | 11 | 29401580 |
Suicidal ideation | 11.37 | 10.19 | 139 | 172797 | 34577 | 29367014 |
Neonatal respiratory failure | 11.36 | 10.19 | 12 | 172924 | 335 | 29401256 |
Bronchopneumopathy | 11.32 | 10.19 | 13 | 172923 | 399 | 29401192 |
Neutrophil count increased | 11.32 | 10.19 | 46 | 172890 | 14696 | 29386895 |
Congenital hydronephrosis | 11.25 | 10.19 | 17 | 172919 | 686 | 29400905 |
C-reactive protein abnormal | 11.20 | 10.19 | 13 | 172923 | 6523 | 29395068 |
Skin indentation | 11.12 | 10.19 | 4 | 172932 | 12 | 29401579 |
Oral discomfort | 11.08 | 10.19 | 35 | 172901 | 2358 | 29399233 |
Tenosynovitis | 11.04 | 10.19 | 4 | 172932 | 3729 | 29397862 |
Toxic neuropathy | 11.00 | 10.19 | 13 | 172923 | 412 | 29401179 |
Hyperparathyroidism | 10.98 | 10.19 | 22 | 172914 | 1115 | 29400476 |
Agitation neonatal | 10.88 | 10.19 | 21 | 172915 | 1035 | 29400556 |
Hair colour changes | 10.85 | 10.19 | 27 | 172909 | 1584 | 29400007 |
Artery dissection | 10.84 | 10.19 | 7 | 172929 | 95 | 29401496 |
Hypertensive nephropathy | 10.82 | 10.19 | 13 | 172923 | 419 | 29401172 |
Altered state of consciousness | 10.77 | 10.19 | 70 | 172866 | 19819 | 29381772 |
Condition aggravated | 10.71 | 10.19 | 724 | 172212 | 145571 | 29256020 |
Blood prolactin decreased | 10.62 | 10.19 | 10 | 172926 | 242 | 29401349 |
Application site inflammation | 10.59 | 10.19 | 7 | 172929 | 99 | 29401492 |
Hospice care | 10.58 | 10.19 | 58 | 172878 | 5010 | 29396581 |
Maternal exposure during pregnancy | 10.58 | 10.19 | 50 | 172886 | 4073 | 29397518 |
Oedema peripheral | 10.58 | 10.19 | 722 | 172214 | 102835 | 29298756 |
Hyperbilirubinaemia neonatal | 10.56 | 10.19 | 17 | 172919 | 725 | 29400866 |
Primary hypothyroidism | 10.55 | 10.19 | 5 | 172931 | 35 | 29401556 |
Subgaleal haematoma | 10.55 | 10.19 | 5 | 172931 | 35 | 29401556 |
Brachydactyly | 10.50 | 10.19 | 9 | 172927 | 192 | 29401399 |
Gangrene neonatal | 10.50 | 10.19 | 9 | 172927 | 192 | 29401399 |
Polycythaemia | 10.48 | 10.19 | 28 | 172908 | 1716 | 29399875 |
Therapy partial responder | 10.45 | 10.19 | 9 | 172927 | 5190 | 29396401 |
Incarcerated umbilical hernia | 10.45 | 10.19 | 4 | 172932 | 15 | 29401576 |
Cervicogenic headache | 10.45 | 10.19 | 4 | 172932 | 15 | 29401576 |
Wrong schedule | 10.42 | 10.19 | 8 | 172928 | 145 | 29401446 |
Thrombocytopenia | 10.42 | 10.19 | 664 | 172272 | 134159 | 29267432 |
Moaning | 10.40 | 10.19 | 17 | 172919 | 734 | 29400857 |
Lip blister | 10.40 | 10.19 | 15 | 172921 | 580 | 29401011 |
CNS germinoma | 10.38 | 10.19 | 3 | 172933 | 3 | 29401588 |
Follicular thyroid cancer | 10.38 | 10.19 | 3 | 172933 | 3 | 29401588 |
Gait inability | 10.38 | 10.19 | 158 | 172778 | 18217 | 29383374 |
Blood glucose decreased | 10.31 | 10.19 | 112 | 172824 | 11957 | 29389634 |
Pseudolymphoma | 10.27 | 10.19 | 14 | 172922 | 513 | 29401078 |
Congenital hypothyroidism | 10.25 | 10.19 | 4 | 172932 | 16 | 29401575 |
Wrong patient received product | 10.23 | 10.19 | 33 | 172903 | 2249 | 29399342 |
Extrapyramidal disorder | 10.19 | 10.19 | 31 | 172905 | 10800 | 29390791 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood thyroid stimulating hormone increased | 750.49 | 10.44 | 613 | 630901 | 7041 | 63860177 |
Hypothyroidism | 654.83 | 10.44 | 1311 | 630203 | 39146 | 63828072 |
Drug ineffective | 579.20 | 10.44 | 5355 | 626159 | 834892 | 63032326 |
Toxicity to various agents | 483.43 | 10.44 | 1877 | 629637 | 361636 | 63505582 |
Drug abuse | 455.45 | 10.44 | 376 | 631138 | 131998 | 63735220 |
Pemphigus | 418.33 | 10.44 | 51 | 631463 | 60650 | 63806568 |
Off label use | 398.23 | 10.44 | 4120 | 627394 | 628686 | 63238532 |
Treatment failure | 351.05 | 10.44 | 375 | 631139 | 116441 | 63750777 |
Febrile neutropenia | 336.79 | 10.44 | 845 | 630669 | 186812 | 63680406 |
Anti-cyclic citrullinated peptide antibody positive | 331.04 | 10.44 | 46 | 631468 | 49516 | 63817702 |
Synovitis | 329.15 | 10.44 | 291 | 631223 | 98799 | 63768419 |
Contraindicated product administered | 326.41 | 10.44 | 344 | 631170 | 107485 | 63759733 |
Fall | 294.63 | 10.44 | 5721 | 625793 | 411105 | 63456113 |
Drug intolerance | 281.22 | 10.44 | 923 | 630591 | 187069 | 63680149 |
Infusion related reaction | 275.00 | 10.44 | 767 | 630747 | 163700 | 63703518 |
Systemic lupus erythematosus | 274.96 | 10.44 | 214 | 631300 | 77398 | 63789820 |
Hand deformity | 273.65 | 10.44 | 136 | 631378 | 62635 | 63804583 |
Completed suicide | 269.16 | 10.44 | 1205 | 630309 | 223209 | 63644009 |
Blood thyroid stimulating hormone decreased | 258.92 | 10.44 | 287 | 631227 | 4943 | 63862275 |
Pericarditis | 245.76 | 10.44 | 154 | 631360 | 62362 | 63804856 |
Blood thyroid stimulating hormone normal | 226.68 | 10.44 | 73 | 631441 | 52 | 63867166 |
Glossodynia | 225.87 | 10.44 | 181 | 631333 | 64515 | 63802703 |
Hyperthyroidism | 215.57 | 10.44 | 520 | 630994 | 17659 | 63849559 |
Drug resistance | 209.32 | 10.44 | 44 | 631470 | 35058 | 63832160 |
Duodenal ulcer perforation | 205.24 | 10.44 | 44 | 631470 | 34581 | 63832637 |
Drug hypersensitivity | 199.01 | 10.44 | 1436 | 630078 | 236379 | 63630839 |
Rheumatoid factor positive | 194.08 | 10.44 | 51 | 631463 | 34887 | 63832331 |
Asthenia | 190.88 | 10.44 | 5513 | 626001 | 422531 | 63444687 |
Product use in unapproved indication | 176.02 | 10.44 | 1011 | 630503 | 175607 | 63691611 |
Blood thyroid stimulating hormone abnormal | 174.24 | 10.44 | 102 | 631412 | 644 | 63866574 |
Dizziness | 174.19 | 10.44 | 5475 | 626039 | 424688 | 63442530 |
Therapeutic product effect decreased | 169.89 | 10.44 | 570 | 630944 | 114781 | 63752437 |
Thyroid function test abnormal | 169.09 | 10.44 | 173 | 631341 | 2706 | 63864512 |
Palpitations | 163.96 | 10.44 | 1654 | 629860 | 102834 | 63764384 |
Arthropathy | 163.34 | 10.44 | 620 | 630894 | 120347 | 63746871 |
Folliculitis | 152.37 | 10.44 | 52 | 631462 | 30025 | 63837193 |
Helicobacter infection | 148.71 | 10.44 | 96 | 631418 | 38266 | 63828952 |
Muscle injury | 147.98 | 10.44 | 38 | 631476 | 26399 | 63840819 |
Neutropenia | 145.97 | 10.44 | 1570 | 629944 | 238054 | 63629164 |
Cytomegalovirus infection | 145.69 | 10.44 | 92 | 631422 | 37107 | 63830111 |
Sleep disorder due to general medical condition, insomnia type | 144.68 | 10.44 | 39 | 631475 | 26231 | 63840987 |
Fatigue | 142.58 | 10.44 | 8814 | 622700 | 739916 | 63127302 |
Thyroid disorder | 133.89 | 10.44 | 330 | 631184 | 11362 | 63855856 |
Pyrexia | 133.29 | 10.44 | 4312 | 627202 | 554332 | 63312886 |
Muscle spasms | 133.07 | 10.44 | 2029 | 629485 | 138994 | 63728224 |
Lower respiratory tract infection | 132.92 | 10.44 | 477 | 631037 | 94137 | 63773081 |
Hyponatraemia | 130.02 | 10.44 | 2108 | 629406 | 146231 | 63720987 |
Hepatic enzyme increased | 129.33 | 10.44 | 744 | 630770 | 129199 | 63738019 |
Headache | 127.26 | 10.44 | 6369 | 625145 | 523098 | 63344120 |
Hepatic function abnormal | 123.68 | 10.44 | 279 | 631235 | 64034 | 63803184 |
Craniopharyngioma | 120.39 | 10.44 | 64 | 631450 | 325 | 63866893 |
Wound | 119.49 | 10.44 | 368 | 631146 | 76109 | 63791109 |
Multiple organ dysfunction syndrome | 116.42 | 10.44 | 553 | 630961 | 100860 | 63766358 |
Balance disorder | 115.49 | 10.44 | 1294 | 630220 | 82632 | 63784586 |
Maternal exposure during pregnancy | 114.72 | 10.44 | 515 | 630999 | 95369 | 63771849 |
Bone marrow failure | 114.15 | 10.44 | 183 | 631331 | 47769 | 63819449 |
Transplant rejection | 111.94 | 10.44 | 18 | 631496 | 17383 | 63849835 |
Infection | 111.86 | 10.44 | 1213 | 630301 | 183667 | 63683551 |
Myalgia | 111.60 | 10.44 | 2177 | 629337 | 156440 | 63710778 |
Intentional overdose | 108.87 | 10.44 | 481 | 631033 | 89463 | 63777755 |
Joint swelling | 107.23 | 10.44 | 1474 | 630040 | 213908 | 63653310 |
Hypersensitivity | 101.94 | 10.44 | 1333 | 630181 | 195119 | 63672099 |
Vertigo | 100.29 | 10.44 | 950 | 630564 | 58061 | 63809157 |
Death | 99.57 | 10.44 | 3793 | 627721 | 478912 | 63388306 |
Nausea | 98.18 | 10.44 | 8947 | 622567 | 776853 | 63090365 |
Product substitution issue | 96.92 | 10.44 | 389 | 631125 | 17472 | 63849746 |
Feeling abnormal | 92.72 | 10.44 | 1830 | 629684 | 131772 | 63735446 |
Discomfort | 90.51 | 10.44 | 445 | 631069 | 80433 | 63786785 |
Product prescribing error | 90.00 | 10.44 | 623 | 630891 | 34646 | 63832572 |
Constipation | 87.11 | 10.44 | 2898 | 628616 | 226439 | 63640779 |
Septic shock | 86.95 | 10.44 | 639 | 630875 | 104798 | 63762420 |
Sepsis | 86.54 | 10.44 | 1661 | 629853 | 228680 | 63638538 |
Myelosuppression | 84.00 | 10.44 | 66 | 631448 | 23764 | 63843454 |
Product quality issue | 83.02 | 10.44 | 538 | 630976 | 29261 | 63837957 |
Product use issue | 82.19 | 10.44 | 1020 | 630494 | 150695 | 63716523 |
Adrenocortical insufficiency acute | 82.07 | 10.44 | 113 | 631401 | 2452 | 63864766 |
Sedation complication | 81.61 | 10.44 | 255 | 631259 | 10099 | 63857119 |
Creatinine renal clearance decreased | 80.59 | 10.44 | 317 | 631197 | 14104 | 63853114 |
Thyroid cancer | 80.31 | 10.44 | 142 | 631372 | 3849 | 63863369 |
Overdose | 79.03 | 10.44 | 1093 | 630421 | 158473 | 63708745 |
Cardiac arrest | 78.94 | 10.44 | 1048 | 630466 | 153016 | 63714202 |
Neurotoxicity | 77.87 | 10.44 | 92 | 631422 | 27312 | 63839906 |
Cardio-respiratory arrest | 77.02 | 10.44 | 605 | 630909 | 97788 | 63769430 |
Toxic epidermal necrolysis | 75.80 | 10.44 | 156 | 631358 | 37010 | 63830208 |
Acute graft versus host disease | 75.78 | 10.44 | 3 | 631511 | 9081 | 63858137 |
Haemophagocytic lymphohistiocytosis | 75.46 | 10.44 | 39 | 631475 | 17570 | 63849648 |
Pathogen resistance | 74.21 | 10.44 | 16 | 631498 | 12527 | 63854691 |
Vision blurred | 73.41 | 10.44 | 1268 | 630246 | 89048 | 63778170 |
Orthostatic hypotension | 73.34 | 10.44 | 740 | 630774 | 45998 | 63821220 |
Venoocclusive liver disease | 72.59 | 10.44 | 7 | 631507 | 10008 | 63857210 |
Blood calcium decreased | 72.20 | 10.44 | 463 | 631051 | 25091 | 63842127 |
Therapy non-responder | 70.65 | 10.44 | 368 | 631146 | 65531 | 63801687 |
Product complaint | 69.44 | 10.44 | 266 | 631248 | 11688 | 63855530 |
Respiratory arrest | 68.65 | 10.44 | 276 | 631238 | 52709 | 63814509 |
Post transplant lymphoproliferative disorder | 68.31 | 10.44 | 7 | 631507 | 9537 | 63857681 |
C-reactive protein abnormal | 68.05 | 10.44 | 112 | 631402 | 28935 | 63838283 |
Neutrophil count decreased | 67.97 | 10.44 | 459 | 631055 | 76737 | 63790481 |
Cognitive disorder | 67.19 | 10.44 | 830 | 630684 | 54257 | 63812961 |
Dry mouth | 66.80 | 10.44 | 894 | 630620 | 59524 | 63807694 |
Dysgeusia | 65.89 | 10.44 | 728 | 630786 | 46319 | 63820899 |
Red blood cell sedimentation rate abnormal | 65.70 | 10.44 | 39 | 631475 | 16267 | 63850951 |
Insulin-like growth factor increased | 65.67 | 10.44 | 81 | 631433 | 1571 | 63865647 |
Irritable bowel syndrome | 65.61 | 10.44 | 170 | 631344 | 37199 | 63830019 |
Haematotoxicity | 64.11 | 10.44 | 23 | 631491 | 12873 | 63854345 |
Pneumocystis jirovecii pneumonia | 62.49 | 10.44 | 109 | 631405 | 27525 | 63839693 |
Pituitary tumour benign | 61.63 | 10.44 | 93 | 631421 | 2200 | 63865018 |
Myxoedema coma | 61.08 | 10.44 | 52 | 631462 | 635 | 63866583 |
Autoimmune thyroiditis | 60.29 | 10.44 | 117 | 631397 | 3411 | 63863807 |
Bronchopulmonary aspergillosis | 59.86 | 10.44 | 59 | 631455 | 19026 | 63848192 |
Cytomegalovirus viraemia | 59.77 | 10.44 | 16 | 631498 | 10812 | 63856406 |
Product formulation issue | 59.76 | 10.44 | 56 | 631458 | 782 | 63866436 |
Respiratory failure | 59.37 | 10.44 | 1166 | 630348 | 160017 | 63707201 |
Syncope | 59.05 | 10.44 | 1989 | 629525 | 155646 | 63711572 |
Swelling | 58.72 | 10.44 | 1160 | 630354 | 159058 | 63708160 |
Hepatotoxicity | 58.44 | 10.44 | 198 | 631316 | 39764 | 63827454 |
Dry skin | 58.21 | 10.44 | 761 | 630753 | 50400 | 63816818 |
Urinary tract infection | 58.13 | 10.44 | 2799 | 628715 | 228797 | 63638421 |
Thrombocytopenia | 57.89 | 10.44 | 1708 | 629806 | 222093 | 63645125 |
Atrial fibrillation | 57.46 | 10.44 | 2132 | 629382 | 168957 | 63698261 |
Disturbance in attention | 57.26 | 10.44 | 635 | 630879 | 40439 | 63826779 |
Substance abuse | 56.74 | 10.44 | 11 | 631503 | 9281 | 63857937 |
Cystitis haemorrhagic | 56.52 | 10.44 | 6 | 631508 | 7950 | 63859268 |
Rheumatoid arthritis | 56.21 | 10.44 | 1203 | 630311 | 163091 | 63704127 |
Enthesopathy | 55.60 | 10.44 | 13 | 631501 | 9625 | 63857593 |
Diarrhoea | 55.47 | 10.44 | 7975 | 623539 | 714729 | 63152489 |
Infective pulmonary exacerbation of cystic fibrosis | 53.79 | 10.44 | 24 | 631490 | 11772 | 63855446 |
Psoriasis | 53.76 | 10.44 | 994 | 630520 | 70709 | 63796509 |
Thyroxine free increased | 53.51 | 10.44 | 60 | 631454 | 1047 | 63866171 |
Suicide attempt | 52.64 | 10.44 | 443 | 631071 | 70564 | 63796654 |
Pain in extremity | 51.88 | 10.44 | 3538 | 627976 | 299547 | 63567671 |
Graft versus host disease | 51.60 | 10.44 | 36 | 631478 | 13777 | 63853441 |
Abdominal discomfort | 51.60 | 10.44 | 1374 | 630140 | 180948 | 63686270 |
Dehydration | 51.53 | 10.44 | 2606 | 628908 | 214157 | 63653061 |
Drug dependence | 51.52 | 10.44 | 161 | 631353 | 33151 | 63834067 |
Multiple-drug resistance | 51.50 | 10.44 | 3 | 631511 | 6499 | 63860719 |
Hot flush | 51.05 | 10.44 | 684 | 630830 | 45551 | 63821667 |
Mucosal inflammation | 50.76 | 10.44 | 381 | 631133 | 62203 | 63805015 |
C-reactive protein increased | 50.66 | 10.44 | 640 | 630874 | 94269 | 63772949 |
Aspergillus infection | 49.81 | 10.44 | 52 | 631462 | 16327 | 63850891 |
Flatulence | 49.08 | 10.44 | 550 | 630964 | 35116 | 63832102 |
Pancytopenia | 48.82 | 10.44 | 1050 | 630464 | 142259 | 63724959 |
Epstein-Barr virus infection | 48.74 | 10.44 | 31 | 631483 | 12457 | 63854761 |
Diffuse alopecia | 48.53 | 10.44 | 43 | 631471 | 556 | 63866662 |
Thyroxine free decreased | 48.32 | 10.44 | 50 | 631464 | 793 | 63866425 |
Papillary thyroid cancer | 47.85 | 10.44 | 83 | 631431 | 2215 | 63865003 |
Adenovirus infection | 47.82 | 10.44 | 7 | 631507 | 7248 | 63859970 |
Intentional product use issue | 47.63 | 10.44 | 652 | 630862 | 94712 | 63772506 |
Disseminated intravascular coagulation | 47.49 | 10.44 | 160 | 631354 | 32188 | 63835030 |
Transient ischaemic attack | 47.30 | 10.44 | 650 | 630864 | 43532 | 63823686 |
Gastrointestinal disorder | 47.11 | 10.44 | 607 | 630907 | 89102 | 63778116 |
Insulin-like growth factor decreased | 47.10 | 10.44 | 41 | 631473 | 517 | 63866701 |
Oedema peripheral | 47.04 | 10.44 | 2514 | 629000 | 207803 | 63659415 |
Pituitary tumour recurrent | 46.90 | 10.44 | 24 | 631490 | 111 | 63867107 |
Reaction to excipient | 46.69 | 10.44 | 63 | 631451 | 1340 | 63865878 |
Chronic graft versus host disease | 46.52 | 10.44 | 4 | 631510 | 6272 | 63860946 |
Thyroidectomy | 46.21 | 10.44 | 48 | 631466 | 765 | 63866453 |
Blood thyroid stimulating hormone | 45.97 | 10.44 | 14 | 631500 | 6 | 63867212 |
Immune reconstitution inflammatory syndrome | 45.93 | 10.44 | 33 | 631481 | 12437 | 63854781 |
Hypertension | 45.87 | 10.44 | 3035 | 628479 | 256226 | 63610992 |
Gait disturbance | 45.82 | 10.44 | 2093 | 629421 | 170062 | 63697156 |
Therapeutic response unexpected | 44.97 | 10.44 | 303 | 631211 | 16698 | 63850520 |
Oral pain | 44.92 | 10.44 | 439 | 631075 | 27054 | 63840164 |
Dysphonia | 44.73 | 10.44 | 670 | 630844 | 45712 | 63821506 |
Cytokine release syndrome | 44.56 | 10.44 | 85 | 631429 | 20744 | 63846474 |
Thrombotic microangiopathy | 44.10 | 10.44 | 59 | 631455 | 16596 | 63850622 |
Tri-iodothyronine decreased | 43.81 | 10.44 | 26 | 631488 | 169 | 63867049 |
Sensitisation | 43.43 | 10.44 | 68 | 631446 | 1663 | 63865555 |
Rheumatoid nodule | 43.39 | 10.44 | 36 | 631478 | 12615 | 63854603 |
Product monitoring error | 42.69 | 10.44 | 134 | 631380 | 5320 | 63861898 |
Malaise | 42.50 | 10.44 | 4466 | 627048 | 391781 | 63475437 |
Muscular weakness | 41.82 | 10.44 | 1583 | 629931 | 125755 | 63741463 |
Ill-defined disorder | 41.80 | 10.44 | 256 | 631258 | 43796 | 63823422 |
Therapeutic response decreased | 41.72 | 10.44 | 319 | 631195 | 51869 | 63815349 |
General physical health deterioration | 41.69 | 10.44 | 2423 | 629091 | 202002 | 63665216 |
Nephropathy toxic | 41.53 | 10.44 | 67 | 631447 | 17447 | 63849771 |
Therapeutic drug monitoring analysis not performed | 41.22 | 10.44 | 55 | 631459 | 1157 | 63866061 |
Graft versus host disease in skin | 40.78 | 10.44 | 3 | 631511 | 5344 | 63861874 |
Gestational diabetes | 40.72 | 10.44 | 134 | 631380 | 5456 | 63861762 |
Panniculitis | 40.59 | 10.44 | 18 | 631496 | 8861 | 63858357 |
Anaphylactic reaction | 40.49 | 10.44 | 453 | 631061 | 68211 | 63799007 |
Poisoning | 40.38 | 10.44 | 97 | 631417 | 21782 | 63845436 |
Drug reaction with eosinophilia and systemic symptoms | 40.29 | 10.44 | 338 | 631176 | 53879 | 63813339 |
Insomnia | 39.98 | 10.44 | 2343 | 629171 | 195493 | 63671725 |
Stomatitis | 39.11 | 10.44 | 797 | 630717 | 108808 | 63758410 |
Thyroid hormones decreased | 39.07 | 10.44 | 29 | 631485 | 286 | 63866932 |
Swollen tongue | 38.96 | 10.44 | 518 | 630996 | 34436 | 63832782 |
Thyroid cancer recurrent | 38.89 | 10.44 | 13 | 631501 | 12 | 63867206 |
Tremor | 38.12 | 10.44 | 1796 | 629718 | 146434 | 63720784 |
Abdominal pain upper | 38.09 | 10.44 | 2087 | 629427 | 172943 | 63694275 |
Acute graft versus host disease in skin | 38.08 | 10.44 | 10 | 631504 | 6845 | 63860373 |
Pneumonia | 37.75 | 10.44 | 4851 | 626663 | 554725 | 63312493 |
Dystonia | 36.95 | 10.44 | 81 | 631433 | 18784 | 63848434 |
Cytomegalovirus infection reactivation | 36.92 | 10.44 | 6 | 631508 | 5750 | 63861468 |
Transplant dysfunction | 36.86 | 10.44 | 10 | 631504 | 6698 | 63860520 |
Tumour lysis syndrome | 36.83 | 10.44 | 85 | 631429 | 19355 | 63847863 |
Weight decreased | 36.73 | 10.44 | 3262 | 628252 | 282477 | 63584741 |
Condition aggravated | 36.68 | 10.44 | 3143 | 628371 | 369283 | 63497935 |
Mucormycosis | 36.65 | 10.44 | 13 | 631501 | 7328 | 63859890 |
Polyomavirus-associated nephropathy | 36.55 | 10.44 | 3 | 631511 | 4885 | 63862333 |
Neutropenic sepsis | 36.32 | 10.44 | 112 | 631402 | 23160 | 63844058 |
Interstitial lung disease | 35.96 | 10.44 | 707 | 630807 | 97025 | 63770193 |
Dysphagia | 35.83 | 10.44 | 1331 | 630183 | 105481 | 63761737 |
Graft versus host disease in gastrointestinal tract | 35.66 | 10.44 | 6 | 631508 | 5606 | 63861612 |
Acute myeloid leukaemia | 35.61 | 10.44 | 143 | 631371 | 27320 | 63839898 |
BK virus infection | 35.54 | 10.44 | 14 | 631500 | 7398 | 63859820 |
Sickle cell anaemia with crisis | 35.48 | 10.44 | 5 | 631509 | 5327 | 63861891 |
Hypophysitis | 35.13 | 10.44 | 95 | 631419 | 3464 | 63863754 |
Therapeutic product effect incomplete | 35.00 | 10.44 | 759 | 630755 | 102723 | 63764495 |
Gastrooesophageal reflux disease | 35.00 | 10.44 | 1064 | 630450 | 82079 | 63785139 |
Dyspepsia | 34.68 | 10.44 | 1031 | 630483 | 79281 | 63787937 |
Thyroid hormones increased | 34.53 | 10.44 | 28 | 631486 | 318 | 63866900 |
Exposure during pregnancy | 34.29 | 10.44 | 544 | 630970 | 77131 | 63790087 |
Hip fracture | 34.21 | 10.44 | 411 | 631103 | 26688 | 63840530 |
Device adhesion issue | 34.19 | 10.44 | 5 | 631509 | 5181 | 63862037 |
Cytomegalovirus chorioretinitis | 34.15 | 10.44 | 4 | 631510 | 4908 | 63862310 |
Impaired healing | 33.69 | 10.44 | 404 | 631110 | 60069 | 63807149 |
Anxiety | 33.48 | 10.44 | 2359 | 629155 | 200290 | 63666928 |
Amnesia | 33.39 | 10.44 | 661 | 630853 | 47608 | 63819610 |
Hypopituitarism | 33.35 | 10.44 | 78 | 631436 | 2595 | 63864623 |
Nervousness | 33.35 | 10.44 | 439 | 631075 | 29117 | 63838101 |
Tenosynovitis | 33.32 | 10.44 | 40 | 631474 | 11793 | 63855425 |
Coma | 32.79 | 10.44 | 632 | 630882 | 86983 | 63780235 |
Decreased appetite | 32.37 | 10.44 | 3186 | 628328 | 278103 | 63589115 |
Bone pain | 32.09 | 10.44 | 649 | 630865 | 46923 | 63820295 |
Blood parathyroid hormone decreased | 32.03 | 10.44 | 16 | 631498 | 7350 | 63859868 |
Thyroxine increased | 31.94 | 10.44 | 36 | 631478 | 632 | 63866586 |
Carpal tunnel syndrome | 31.61 | 10.44 | 264 | 631250 | 15564 | 63851654 |
Trichorrhexis | 31.39 | 10.44 | 37 | 631477 | 683 | 63866535 |
Ageusia | 31.20 | 10.44 | 237 | 631277 | 13576 | 63853642 |
Pulmonary tuberculosis | 31.10 | 10.44 | 16 | 631498 | 7228 | 63859990 |
Lymphocyte count decreased | 31.03 | 10.44 | 252 | 631262 | 40447 | 63826771 |
Myxoedema | 30.96 | 10.44 | 18 | 631496 | 112 | 63867106 |
Pseudomonas infection | 30.90 | 10.44 | 82 | 631432 | 17801 | 63849417 |
Disease progression | 30.71 | 10.44 | 1106 | 630408 | 140574 | 63726644 |
Metastatic renal cell carcinoma | 30.65 | 10.44 | 67 | 631447 | 2129 | 63865089 |
Musculoskeletal stiffness | 30.41 | 10.44 | 946 | 630568 | 122260 | 63744958 |
Unintentional medical device removal | 30.24 | 10.44 | 14 | 631500 | 6720 | 63860498 |
Blood pressure increased | 29.96 | 10.44 | 2017 | 629497 | 170535 | 63696683 |
Chronic pigmented purpura | 29.85 | 10.44 | 20 | 631494 | 165 | 63867053 |
Respiratory depression | 29.81 | 10.44 | 123 | 631391 | 23320 | 63843898 |
Aplastic anaemia | 29.61 | 10.44 | 57 | 631457 | 13863 | 63853355 |
Epiphysiolysis | 29.53 | 10.44 | 16 | 631498 | 85 | 63867133 |
Acute respiratory distress syndrome | 29.26 | 10.44 | 242 | 631272 | 38693 | 63828525 |
Drug tolerance decreased | 29.25 | 10.44 | 16 | 631498 | 6982 | 63860236 |
Full blood count abnormal | 29.14 | 10.44 | 431 | 631083 | 29326 | 63837892 |
Accidental exposure to product | 28.94 | 10.44 | 146 | 631368 | 26218 | 63841000 |
Body height decreased | 28.63 | 10.44 | 148 | 631366 | 7406 | 63859812 |
Nocardiosis | 28.37 | 10.44 | 6 | 631508 | 4761 | 63862457 |
Thyroxine decreased | 28.26 | 10.44 | 33 | 631481 | 603 | 63866615 |
Feeling cold | 28.11 | 10.44 | 355 | 631159 | 23323 | 63843895 |
Influenza like illness | 27.98 | 10.44 | 797 | 630717 | 60905 | 63806313 |
Drug ineffective for unapproved indication | 27.95 | 10.44 | 184 | 631330 | 30949 | 63836269 |
Myelodysplastic syndrome | 27.90 | 10.44 | 157 | 631357 | 27422 | 63839796 |
Drug eruption | 27.89 | 10.44 | 223 | 631291 | 35913 | 63831305 |
Foreign body in reproductive tract | 27.62 | 10.44 | 28 | 631486 | 433 | 63866785 |
Tropical infectious disease | 27.35 | 10.44 | 12 | 631502 | 36 | 63867182 |
Papillitis | 27.05 | 10.44 | 13 | 631501 | 51 | 63867167 |
Polycystic ovaries | 27.02 | 10.44 | 63 | 631451 | 2092 | 63865126 |
Burning sensation | 27.00 | 10.44 | 657 | 630857 | 49007 | 63818211 |
Status epilepticus | 26.72 | 10.44 | 115 | 631399 | 21548 | 63845670 |
Product taste abnormal | 26.71 | 10.44 | 60 | 631454 | 1943 | 63865275 |
Oral discomfort | 26.70 | 10.44 | 157 | 631357 | 8249 | 63858969 |
Memory impairment | 26.44 | 10.44 | 1058 | 630456 | 84624 | 63782594 |
Pulmonary malformation | 26.31 | 10.44 | 17 | 631497 | 131 | 63867087 |
Hypersomnia | 26.20 | 10.44 | 302 | 631212 | 19415 | 63847803 |
Bone erosion | 25.98 | 10.44 | 46 | 631468 | 11549 | 63855669 |
Swelling face | 25.94 | 10.44 | 761 | 630753 | 58405 | 63808813 |
Tenderness | 25.94 | 10.44 | 300 | 631214 | 19302 | 63847916 |
Hip arthroplasty | 25.93 | 10.44 | 114 | 631400 | 21237 | 63845981 |
Bacteraemia | 25.73 | 10.44 | 156 | 631358 | 26755 | 63840463 |
Rash | 25.65 | 10.44 | 4020 | 627494 | 454529 | 63412689 |
Device difficult to use | 25.65 | 10.44 | 35 | 631479 | 9763 | 63857455 |
Dry eye | 25.61 | 10.44 | 413 | 631101 | 28606 | 63838612 |
Alanine aminotransferase increased | 25.43 | 10.44 | 1107 | 630407 | 137924 | 63729294 |
Product physical issue | 25.41 | 10.44 | 83 | 631431 | 3366 | 63863852 |
Granulocytopenia | 25.22 | 10.44 | 182 | 631332 | 10258 | 63856960 |
Goitre | 25.16 | 10.44 | 106 | 631408 | 4867 | 63862351 |
Visual impairment | 25.06 | 10.44 | 924 | 630590 | 73153 | 63794065 |
Product dose omission issue | 24.96 | 10.44 | 2223 | 629291 | 192524 | 63674694 |
Ejection fraction | 24.91 | 10.44 | 45 | 631469 | 1241 | 63865977 |
Paraesthesia | 24.88 | 10.44 | 1581 | 629933 | 132941 | 63734277 |
Blister | 24.81 | 10.44 | 603 | 630911 | 80364 | 63786854 |
Altered state of consciousness | 24.80 | 10.44 | 244 | 631270 | 37658 | 63829560 |
Tri-iodothyronine increased | 24.80 | 10.44 | 18 | 631496 | 171 | 63867047 |
Weight increased | 24.75 | 10.44 | 2418 | 629096 | 210930 | 63656288 |
Cardiotoxicity | 24.64 | 10.44 | 39 | 631475 | 10235 | 63856983 |
Jaw disorder | 24.60 | 10.44 | 100 | 631414 | 4517 | 63862701 |
Poisoning deliberate | 24.57 | 10.44 | 60 | 631454 | 13398 | 63853820 |
Somatic delusion | 24.53 | 10.44 | 32 | 631482 | 658 | 63866560 |
Head discomfort | 24.50 | 10.44 | 199 | 631315 | 11635 | 63855583 |
Hypoglycaemia | 24.36 | 10.44 | 1095 | 630419 | 88797 | 63778421 |
Eye swelling | 24.34 | 10.44 | 329 | 631185 | 21952 | 63845266 |
Platelet count decreased | 24.14 | 10.44 | 1369 | 630145 | 166342 | 63700876 |
Lipodystrophy acquired | 24.10 | 10.44 | 5 | 631509 | 4022 | 63863196 |
Autoimmune hepatitis | 23.90 | 10.44 | 175 | 631339 | 9909 | 63857309 |
Secondary hypogonadism | 23.77 | 10.44 | 23 | 631491 | 335 | 63866883 |
Diverticulum | 23.69 | 10.44 | 215 | 631299 | 12983 | 63854235 |
Virologic failure | 23.66 | 10.44 | 3 | 631511 | 3463 | 63863755 |
Haemorrhoids | 23.64 | 10.44 | 348 | 631166 | 23653 | 63843565 |
Myocardial infarction | 23.61 | 10.44 | 1355 | 630159 | 164466 | 63702752 |
Red blood cell sedimentation rate | 23.54 | 10.44 | 4 | 631510 | 3710 | 63863508 |
Product colour issue | 23.51 | 10.44 | 30 | 631484 | 603 | 63866615 |
Febrile bone marrow aplasia | 23.15 | 10.44 | 47 | 631467 | 11208 | 63856010 |
Enterococcal infection | 22.89 | 10.44 | 65 | 631449 | 13801 | 63853417 |
Cardiogenic shock | 22.83 | 10.44 | 205 | 631309 | 32222 | 63834996 |
Gallbladder disorder | 22.70 | 10.44 | 261 | 631253 | 16769 | 63850449 |
Arrhythmia | 22.67 | 10.44 | 679 | 630835 | 52265 | 63814953 |
Therapy partial responder | 22.65 | 10.44 | 41 | 631473 | 10207 | 63857011 |
Intentional self-injury | 22.52 | 10.44 | 179 | 631335 | 28865 | 63838353 |
Endocrine ophthalmopathy | 22.50 | 10.44 | 24 | 631490 | 395 | 63866823 |
Leukopenia | 22.47 | 10.44 | 788 | 630726 | 100454 | 63766764 |
Sciatica | 22.45 | 10.44 | 300 | 631214 | 19964 | 63847254 |
Blood glucose increased | 22.44 | 10.44 | 1175 | 630339 | 96898 | 63770320 |
Hypoacusis | 22.40 | 10.44 | 367 | 631147 | 25500 | 63841718 |
Inner ear disorder | 22.35 | 10.44 | 27 | 631487 | 512 | 63866706 |
Retrograde amnesia | 22.35 | 10.44 | 26 | 631488 | 473 | 63866745 |
Exposure via ingestion | 22.31 | 10.44 | 10 | 631504 | 4892 | 63862326 |
Acute lymphocytic leukaemia recurrent | 22.13 | 10.44 | 6 | 631508 | 4020 | 63863198 |
Labyrinthitis | 21.98 | 10.44 | 66 | 631448 | 2557 | 63864661 |
Ankylosing spondylitis | 21.97 | 10.44 | 29 | 631485 | 8205 | 63859013 |
Pneumonia fungal | 21.96 | 10.44 | 33 | 631481 | 8844 | 63858374 |
Hypoxia | 21.95 | 10.44 | 676 | 630838 | 87473 | 63779745 |
Posterior reversible encephalopathy syndrome | 21.95 | 10.44 | 133 | 631381 | 22813 | 63844405 |
Product odour abnormal | 21.89 | 10.44 | 40 | 631474 | 1113 | 63866105 |
Head injury | 21.80 | 10.44 | 447 | 631067 | 32395 | 63834823 |
Exposure to toxic agent | 21.78 | 10.44 | 17 | 631497 | 6142 | 63861076 |
Tongue discomfort | 21.70 | 10.44 | 57 | 631457 | 2042 | 63865176 |
Haematoma | 21.69 | 10.44 | 600 | 630914 | 45650 | 63821568 |
Metabolic acidosis | 21.59 | 10.44 | 529 | 630985 | 70429 | 63796789 |
Paradoxical drug reaction | 21.51 | 10.44 | 17 | 631497 | 6103 | 63861115 |
Cerebral infarction | 21.44 | 10.44 | 278 | 631236 | 40766 | 63826452 |
Cerebrovascular accident | 21.24 | 10.44 | 1593 | 629921 | 135990 | 63731228 |
Pneumonia cytomegaloviral | 21.13 | 10.44 | 8 | 631506 | 4331 | 63862887 |
Spinal stenosis | 21.10 | 10.44 | 219 | 631295 | 13712 | 63853506 |
Drug use disorder | 21.04 | 10.44 | 17 | 631497 | 6037 | 63861181 |
Scleral discolouration | 21.01 | 10.44 | 26 | 631488 | 506 | 63866712 |
Lip blister | 21.01 | 10.44 | 59 | 631455 | 2200 | 63865018 |
Pelvic fracture | 21.00 | 10.44 | 176 | 631338 | 10387 | 63856831 |
Skin necrosis | 20.94 | 10.44 | 71 | 631443 | 14258 | 63852960 |
Skin haemorrhage | 20.93 | 10.44 | 150 | 631364 | 8435 | 63858783 |
Malabsorption | 20.85 | 10.44 | 92 | 631422 | 4311 | 63862907 |
Lymphoproliferative disorder | 20.85 | 10.44 | 12 | 631502 | 5091 | 63862127 |
Diffuse large B-cell lymphoma recurrent | 20.82 | 10.44 | 3 | 631511 | 3143 | 63864075 |
Blood growth hormone increased | 20.81 | 10.44 | 28 | 631486 | 594 | 63866624 |
Staphylococcal infection | 20.70 | 10.44 | 360 | 631154 | 50318 | 63816900 |
Respiratory disorder | 20.59 | 10.44 | 240 | 631274 | 35871 | 63831347 |
Adrenal insufficiency | 20.59 | 10.44 | 322 | 631192 | 22165 | 63845053 |
Nasopharyngitis | 20.58 | 10.44 | 1646 | 629868 | 194427 | 63672791 |
Drug abuser | 20.58 | 10.44 | 16 | 631498 | 5792 | 63861426 |
Disorientation | 20.52 | 10.44 | 703 | 630811 | 55125 | 63812093 |
Lip swelling | 20.44 | 10.44 | 432 | 631082 | 31475 | 63835743 |
Viral mutation identified | 20.35 | 10.44 | 4 | 631510 | 3342 | 63863876 |
Atrioventricular block | 20.19 | 10.44 | 193 | 631321 | 11822 | 63855396 |
Kidney transplant rejection | 20.18 | 10.44 | 39 | 631475 | 9472 | 63857746 |
Serotonin syndrome | 20.17 | 10.44 | 267 | 631247 | 39015 | 63828203 |
Lymphadenectomy | 20.15 | 10.44 | 36 | 631478 | 984 | 63866234 |
Disease recurrence | 20.14 | 10.44 | 204 | 631310 | 31306 | 63835912 |
Renal impairment | 20.00 | 10.44 | 1099 | 630415 | 133918 | 63733300 |
Intentional product misuse | 19.86 | 10.44 | 547 | 630967 | 71748 | 63795470 |
Medulloblastoma recurrent | 19.83 | 10.44 | 13 | 631501 | 103 | 63867115 |
Reversible airways obstruction | 19.76 | 10.44 | 38 | 631476 | 1100 | 63866118 |
Anti-thyroid antibody positive | 19.75 | 10.44 | 24 | 631490 | 458 | 63866760 |
Alanine aminotransferase abnormal | 19.70 | 10.44 | 23 | 631491 | 6865 | 63860353 |
Milk-alkali syndrome | 19.70 | 10.44 | 39 | 631475 | 1154 | 63866064 |
Haematochezia | 19.65 | 10.44 | 816 | 630698 | 65557 | 63801661 |
Choking | 19.59 | 10.44 | 173 | 631341 | 10365 | 63856853 |
Diabetes insipidus | 19.57 | 10.44 | 92 | 631422 | 4429 | 63862789 |
Hypogammaglobulinaemia | 19.53 | 10.44 | 45 | 631469 | 10254 | 63856964 |
Cardiac disorder | 19.31 | 10.44 | 698 | 630816 | 55118 | 63812100 |
Pre-existing condition improved | 19.24 | 10.44 | 95 | 631419 | 4667 | 63862551 |
Intervertebral disc protrusion | 19.20 | 10.44 | 291 | 631223 | 19900 | 63847318 |
Cytopenia | 19.16 | 10.44 | 82 | 631432 | 15389 | 63851829 |
Juvenile idiopathic arthritis | 19.14 | 10.44 | 7 | 631507 | 3872 | 63863346 |
Medullary thyroid cancer | 19.12 | 10.44 | 14 | 631500 | 135 | 63867083 |
Thyrotoxic crisis | 19.06 | 10.44 | 37 | 631477 | 1079 | 63866139 |
Poor quality product administered | 19.05 | 10.44 | 72 | 631442 | 3143 | 63864075 |
Blood cholesterol increased | 19.05 | 10.44 | 633 | 630881 | 49433 | 63817785 |
Skin toxicity | 18.93 | 10.44 | 22 | 631492 | 6580 | 63860638 |
Broncholithiasis | 18.79 | 10.44 | 14 | 631500 | 139 | 63867079 |
Extremity contracture | 18.75 | 10.44 | 46 | 631468 | 1579 | 63865639 |
Persistent depressive disorder | 18.73 | 10.44 | 35 | 631479 | 991 | 63866227 |
Abdominal distension | 18.63 | 10.44 | 1133 | 630381 | 94861 | 63772357 |
Swollen joint count increased | 18.62 | 10.44 | 29 | 631485 | 7660 | 63859558 |
Gastrointestinal motility disorder | 18.62 | 10.44 | 100 | 631414 | 5079 | 63862139 |
Cholelithiasis | 18.52 | 10.44 | 580 | 630934 | 44926 | 63822292 |
Low turnover osteopathy | 18.49 | 10.44 | 50 | 631464 | 1823 | 63865395 |
Device related infection | 18.47 | 10.44 | 201 | 631313 | 30425 | 63836793 |
Cerebral haematoma | 18.37 | 10.44 | 127 | 631387 | 7058 | 63860160 |
Dyspnoea | 18.36 | 10.44 | 7548 | 623966 | 711126 | 63156092 |
Hiatus hernia | 18.36 | 10.44 | 286 | 631228 | 19671 | 63847547 |
Incorrect route of product administration | 18.34 | 10.44 | 143 | 631371 | 23155 | 63844063 |
Eating disorder | 18.29 | 10.44 | 248 | 631266 | 16557 | 63850661 |
Prostate cancer | 18.28 | 10.44 | 116 | 631398 | 19679 | 63847539 |
Staphylococcal sepsis | 18.12 | 10.44 | 65 | 631449 | 12834 | 63854384 |
Eye irritation | 18.09 | 10.44 | 236 | 631278 | 15620 | 63851598 |
Pituitary tumour | 18.08 | 10.44 | 36 | 631478 | 1070 | 63866148 |
Aggression | 18.06 | 10.44 | 331 | 631183 | 45901 | 63821317 |
Systemic infection | 18.03 | 10.44 | 87 | 631427 | 4234 | 63862984 |
Tooth fracture | 17.96 | 10.44 | 162 | 631352 | 9765 | 63857453 |
Electrocardiogram ST segment elevation | 17.94 | 10.44 | 27 | 631487 | 7232 | 63859986 |
Immunosuppressant drug level increased | 17.94 | 10.44 | 27 | 631487 | 7232 | 63859986 |
Spinal osteoarthritis | 17.88 | 10.44 | 217 | 631297 | 14124 | 63853094 |
Exophthalmos | 17.83 | 10.44 | 44 | 631470 | 1516 | 63865702 |
Labile hypertension | 17.80 | 10.44 | 24 | 631490 | 510 | 63866708 |
Pneumatosis intestinalis | 17.78 | 10.44 | 15 | 631499 | 5214 | 63862004 |
Anosmia | 17.76 | 10.44 | 88 | 631426 | 4329 | 63862889 |
Liver function test abnormal | 17.75 | 10.44 | 731 | 630783 | 58670 | 63808548 |
Vaginal haemorrhage | 17.71 | 10.44 | 277 | 631237 | 19067 | 63848151 |
Traumatic ulcer | 17.69 | 10.44 | 9 | 631505 | 41 | 63867177 |
Depression | 17.69 | 10.44 | 2052 | 629462 | 181239 | 63685979 |
Erythema dyschromicum perstans | 17.62 | 10.44 | 10 | 631504 | 59 | 63867159 |
Thyroid cancer metastatic | 17.62 | 10.44 | 13 | 631501 | 127 | 63867091 |
Breast cancer | 17.51 | 10.44 | 391 | 631123 | 28757 | 63838461 |
Soft tissue disorder | 17.49 | 10.44 | 71 | 631443 | 3205 | 63864013 |
Chest pain | 17.49 | 10.44 | 2600 | 628914 | 233380 | 63633838 |
Hyperchromic anaemia | 17.33 | 10.44 | 14 | 631500 | 158 | 63867060 |
Rheumatic fever | 17.31 | 10.44 | 41 | 631473 | 9253 | 63857965 |
Product measured potency issue | 17.31 | 10.44 | 15 | 631499 | 188 | 63867030 |
Thyroxine abnormal | 17.25 | 10.44 | 6 | 631508 | 7 | 63867211 |
Application site erythema | 17.17 | 10.44 | 91 | 631423 | 4598 | 63862620 |
Product solubility abnormal | 17.07 | 10.44 | 30 | 631484 | 809 | 63866409 |
Acute graft versus host disease in intestine | 17.00 | 10.44 | 7 | 631507 | 3602 | 63863616 |
Drug level increased | 16.99 | 10.44 | 234 | 631280 | 33962 | 63833256 |
Growth hormone deficiency | 16.93 | 10.44 | 19 | 631495 | 332 | 63866886 |
Transcription medication error | 16.93 | 10.44 | 19 | 631495 | 332 | 63866886 |
Fungaemia | 16.80 | 10.44 | 8 | 631506 | 3777 | 63863441 |
Hyperbilirubinaemia | 16.76 | 10.44 | 130 | 631384 | 21075 | 63846143 |
Brain oedema | 16.68 | 10.44 | 137 | 631377 | 21938 | 63845280 |
Amniotic fluid volume increased | 16.66 | 10.44 | 13 | 631501 | 139 | 63867079 |
Bradycardia | 16.63 | 10.44 | 1359 | 630155 | 116860 | 63750358 |
Ascites | 16.55 | 10.44 | 471 | 631043 | 61530 | 63805688 |
Adenoiditis | 16.53 | 10.44 | 8 | 631506 | 32 | 63867186 |
Thyrotoxic periodic paralysis | 16.49 | 10.44 | 11 | 631503 | 90 | 63867128 |
Anaemia folate deficiency | 16.49 | 10.44 | 16 | 631498 | 234 | 63866984 |
Blood glucose decreased | 16.11 | 10.44 | 317 | 631197 | 22806 | 63844412 |
Device use error | 16.06 | 10.44 | 24 | 631490 | 6447 | 63860771 |
Anaemia vitamin B12 deficiency | 16.05 | 10.44 | 24 | 631490 | 563 | 63866655 |
Thyroglobulin decreased | 15.86 | 10.44 | 5 | 631509 | 3 | 63867215 |
Presbyacusis | 15.83 | 10.44 | 3 | 631511 | 2572 | 63864646 |
Follicular thyroid cancer | 15.80 | 10.44 | 10 | 631504 | 74 | 63867144 |
Potassium wasting nephropathy | 15.79 | 10.44 | 13 | 631501 | 151 | 63867067 |
Increased tendency to bruise | 15.72 | 10.44 | 149 | 631365 | 9106 | 63858112 |
Rapid eye movement sleep behaviour disorder | 15.67 | 10.44 | 18 | 631496 | 323 | 63866895 |
Liver disorder | 15.62 | 10.44 | 400 | 631114 | 52951 | 63814267 |
Lung cyst | 15.59 | 10.44 | 13 | 631501 | 154 | 63867064 |
Endocrine disorder | 15.58 | 10.44 | 26 | 631488 | 672 | 63866546 |
Oculogyric crisis | 15.51 | 10.44 | 3 | 631511 | 2535 | 63864683 |
Venoocclusive disease | 15.40 | 10.44 | 10 | 631504 | 3975 | 63863243 |
Gingival pain | 15.38 | 10.44 | 111 | 631403 | 6256 | 63860962 |
Hepatitis B | 15.38 | 10.44 | 33 | 631481 | 7712 | 63859506 |
Diffuse large B-cell lymphoma | 15.38 | 10.44 | 51 | 631463 | 10310 | 63856908 |
Meniere's disease | 15.32 | 10.44 | 13 | 631501 | 158 | 63867060 |
Lactose intolerance | 15.29 | 10.44 | 49 | 631465 | 1967 | 63865251 |
Tooth dislocation | 15.27 | 10.44 | 7 | 631507 | 24 | 63867194 |
Seronegative arthritis | 15.24 | 10.44 | 4 | 631510 | 2739 | 63864479 |
Rhinitis allergic | 15.22 | 10.44 | 133 | 631381 | 7945 | 63859273 |
Frontotemporal dementia | 15.16 | 10.44 | 22 | 631492 | 502 | 63866716 |
Cerebral microangiopathy | 15.16 | 10.44 | 15 | 631499 | 225 | 63866993 |
Bone loss | 15.11 | 10.44 | 51 | 631463 | 2104 | 63865114 |
Intercapillary glomerulosclerosis | 15.10 | 10.44 | 9 | 631505 | 59 | 63867159 |
Vascular stent thrombosis | 15.10 | 10.44 | 7 | 631507 | 3357 | 63863861 |
Dysstasia | 15.09 | 10.44 | 315 | 631199 | 22900 | 63844318 |
Wrist fracture | 15.04 | 10.44 | 157 | 631357 | 9844 | 63857374 |
Systemic candida | 15.02 | 10.44 | 18 | 631496 | 5311 | 63861907 |
Listless | 15.02 | 10.44 | 68 | 631446 | 3222 | 63863996 |
Neuromyopathy | 15.02 | 10.44 | 38 | 631476 | 1330 | 63865888 |
Varicose vein | 15.01 | 10.44 | 74 | 631440 | 3633 | 63863585 |
Ileus paralytic | 14.99 | 10.44 | 38 | 631476 | 8377 | 63858841 |
Anaphylactic shock | 14.90 | 10.44 | 208 | 631306 | 30120 | 63837098 |
Cortisol decreased | 14.82 | 10.44 | 43 | 631471 | 1634 | 63865584 |
Change of bowel habit | 14.78 | 10.44 | 55 | 631459 | 2383 | 63864835 |
Disability | 14.78 | 10.44 | 65 | 631449 | 12107 | 63855111 |
Blood calcium increased | 14.75 | 10.44 | 138 | 631376 | 8404 | 63858814 |
Neuroleptic malignant syndrome | 14.69 | 10.44 | 165 | 631349 | 24831 | 63842387 |
Product administered to patient of inappropriate age | 14.69 | 10.44 | 14 | 631500 | 4587 | 63862631 |
Bacterial sepsis | 14.62 | 10.44 | 32 | 631482 | 7425 | 63859793 |
Pleural fibrosis | 14.55 | 10.44 | 11 | 631503 | 4039 | 63863179 |
Full blood count decreased | 14.55 | 10.44 | 306 | 631208 | 22276 | 63844942 |
Tonsillar cyst | 14.54 | 10.44 | 4 | 631510 | 0 | 63867218 |
Mydriasis | 14.51 | 10.44 | 89 | 631425 | 15223 | 63851995 |
Decreased bronchial secretion | 14.51 | 10.44 | 9 | 631505 | 64 | 63867154 |
Parainfluenzae virus infection | 14.49 | 10.44 | 15 | 631499 | 4728 | 63862490 |
Urine odour abnormal | 14.47 | 10.44 | 93 | 631421 | 5043 | 63862175 |
Stenotrophomonas infection | 14.47 | 10.44 | 6 | 631508 | 3074 | 63864144 |
Polyglandular autoimmune syndrome type II | 14.46 | 10.44 | 7 | 631507 | 28 | 63867190 |
Pneumonia bacterial | 14.46 | 10.44 | 87 | 631427 | 14948 | 63852270 |
Magnetic resonance imaging thoracic abnormal | 14.45 | 10.44 | 6 | 631508 | 15 | 63867203 |
N-terminal prohormone brain natriuretic peptide abnormal | 14.44 | 10.44 | 15 | 631499 | 239 | 63866979 |
Thyroiditis | 14.43 | 10.44 | 72 | 631442 | 3552 | 63863666 |
Temperature regulation disorder | 14.42 | 10.44 | 12 | 631502 | 4199 | 63863019 |
Oropharyngeal pain | 14.40 | 10.44 | 1033 | 630481 | 87834 | 63779384 |
Back pain | 14.37 | 10.44 | 2719 | 628795 | 247452 | 63619766 |
Breast discomfort | 14.33 | 10.44 | 17 | 631497 | 316 | 63866902 |
Pneumonia viral | 14.33 | 10.44 | 128 | 631386 | 7694 | 63859524 |
Abnormal weight gain | 14.33 | 10.44 | 51 | 631463 | 2162 | 63865056 |
Vessel puncture site haemorrhage | 14.31 | 10.44 | 13 | 631501 | 174 | 63867044 |
Metastases to pituitary gland | 14.30 | 10.44 | 5 | 631509 | 6 | 63867212 |
Abdominal pain | 14.28 | 10.44 | 3358 | 628156 | 309017 | 63558201 |
Product blister packaging issue | 14.26 | 10.44 | 12 | 631502 | 144 | 63867074 |
Agranulocytosis | 14.22 | 10.44 | 276 | 631238 | 37953 | 63829265 |
Pollakiuria | 14.22 | 10.44 | 407 | 631107 | 31123 | 63836095 |
Pregnancy | 14.21 | 10.44 | 133 | 631381 | 20732 | 63846486 |
Impaired driving ability | 14.19 | 10.44 | 86 | 631428 | 4568 | 63862650 |
Contusion | 14.15 | 10.44 | 1298 | 630216 | 112667 | 63754551 |
Delayed graft function | 14.13 | 10.44 | 6 | 631508 | 3030 | 63864188 |
Palmar-plantar erythrodysaesthesia syndrome | 14.12 | 10.44 | 376 | 631138 | 28443 | 63838775 |
Diffuse alveolar damage | 14.11 | 10.44 | 7 | 631507 | 3228 | 63863990 |
COVID-19 pneumonia | 14.09 | 10.44 | 99 | 631415 | 16405 | 63850813 |
Kounis syndrome | 14.04 | 10.44 | 6 | 631508 | 3019 | 63864199 |
Intervertebral disc degeneration | 14.03 | 10.44 | 193 | 631321 | 12927 | 63854291 |
Piloerection | 13.98 | 10.44 | 19 | 631495 | 407 | 63866811 |
Sedation | 13.98 | 10.44 | 517 | 630997 | 40945 | 63826273 |
Empty sella syndrome | 13.97 | 10.44 | 9 | 631505 | 69 | 63867149 |
Pneumonia aspiration | 13.92 | 10.44 | 458 | 631056 | 58813 | 63808405 |
Fibromyalgia | 13.91 | 10.44 | 453 | 631061 | 35278 | 63831940 |
Viraemia | 13.89 | 10.44 | 3 | 631511 | 2346 | 63864872 |
Scar | 13.89 | 10.44 | 196 | 631318 | 13202 | 63854016 |
Anal prolapse | 13.86 | 10.44 | 9 | 631505 | 70 | 63867148 |
Ventricular fibrillation | 13.83 | 10.44 | 158 | 631356 | 23702 | 63843516 |
Intentional underdose | 13.81 | 10.44 | 48 | 631466 | 2010 | 63865208 |
Total lung capacity abnormal | 13.81 | 10.44 | 12 | 631502 | 151 | 63867067 |
Body height increased | 13.78 | 10.44 | 10 | 631504 | 95 | 63867123 |
Pulmonary alveolar haemorrhage | 13.73 | 10.44 | 49 | 631465 | 9689 | 63857529 |
Pulmonary valve incompetence | 13.71 | 10.44 | 41 | 631473 | 1585 | 63865633 |
Cytomegalovirus colitis | 13.69 | 10.44 | 11 | 631503 | 3917 | 63863301 |
Diabetic ketoacidosis | 13.66 | 10.44 | 386 | 631128 | 29459 | 63837759 |
Upper limb fracture | 13.66 | 10.44 | 213 | 631301 | 14653 | 63852565 |
Complications of transplanted kidney | 13.64 | 10.44 | 20 | 631494 | 5415 | 63861803 |
Atrioventricular block first degree | 13.63 | 10.44 | 163 | 631351 | 10571 | 63856647 |
Gastritis | 13.55 | 10.44 | 528 | 630986 | 42090 | 63825128 |
Cryptococcosis | 13.55 | 10.44 | 5 | 631509 | 2750 | 63864468 |
Drug interaction | 13.51 | 10.44 | 3241 | 628273 | 358842 | 63508376 |
Abdominal pain lower | 13.45 | 10.44 | 347 | 631167 | 26122 | 63841096 |
Paronychia | 13.45 | 10.44 | 27 | 631487 | 6465 | 63860753 |
Pancreatic neuroendocrine tumour | 13.41 | 10.44 | 20 | 631494 | 468 | 63866750 |
Blood calcitonin increased | 13.41 | 10.44 | 7 | 631507 | 34 | 63867184 |
Disturbance in social behaviour | 13.41 | 10.44 | 11 | 631503 | 3876 | 63863342 |
Acute lung injury | 13.36 | 10.44 | 5 | 631509 | 2726 | 63864492 |
Panic disorder | 13.36 | 10.44 | 58 | 631456 | 2699 | 63864519 |
Sexual dysfunction | 13.33 | 10.44 | 27 | 631487 | 6444 | 63860774 |
Knee arthroplasty | 13.33 | 10.44 | 185 | 631329 | 26814 | 63840404 |
Pulmonary arterial hypertension | 13.31 | 10.44 | 334 | 631180 | 25033 | 63842185 |
Hormone level abnormal | 13.27 | 10.44 | 42 | 631472 | 1675 | 63865543 |
Suspected suicide | 13.26 | 10.44 | 42 | 631472 | 8612 | 63858606 |
Deep brain stimulation | 13.24 | 10.44 | 8 | 631506 | 54 | 63867164 |
Acute hepatic failure | 13.22 | 10.44 | 178 | 631336 | 25934 | 63841284 |
Hyperhidrosis | 13.21 | 10.44 | 1407 | 630107 | 123513 | 63743705 |
Skin irritation | 13.21 | 10.44 | 143 | 631371 | 9051 | 63858167 |
Blood loss anaemia | 13.13 | 10.44 | 200 | 631314 | 13692 | 63853526 |
Pituitary cyst | 13.12 | 10.44 | 5 | 631509 | 9 | 63867209 |
Sinus bradycardia | 13.10 | 10.44 | 305 | 631209 | 22588 | 63844630 |
Supraventricular extrasystoles | 13.09 | 10.44 | 101 | 631413 | 5814 | 63861404 |
Shock | 13.06 | 10.44 | 280 | 631234 | 37960 | 63829258 |
Skin ulcer | 13.06 | 10.44 | 329 | 631185 | 43645 | 63823573 |
Alcohol abuse | 13.04 | 10.44 | 17 | 631497 | 4835 | 63862383 |
Pseudomonal sepsis | 13.02 | 10.44 | 19 | 631495 | 5153 | 63862065 |
Gingival disorder | 13.01 | 10.44 | 66 | 631448 | 3278 | 63863940 |
Metastases to neck | 13.00 | 10.44 | 6 | 631508 | 21 | 63867197 |
Stress fracture | 12.99 | 10.44 | 97 | 631417 | 5527 | 63861691 |
Spondylolisthesis | 12.94 | 10.44 | 58 | 631456 | 2736 | 63864482 |
Dementia | 12.93 | 10.44 | 280 | 631234 | 20486 | 63846732 |
Hyperthermia malignant | 12.90 | 10.44 | 4 | 631510 | 2455 | 63864763 |
Feeling jittery | 12.86 | 10.44 | 160 | 631354 | 10475 | 63856743 |
Madarosis | 12.84 | 10.44 | 51 | 631463 | 2279 | 63864939 |
Immediate post-injection reaction | 12.83 | 10.44 | 16 | 631498 | 314 | 63866904 |
Mineral deficiency | 12.80 | 10.44 | 7 | 631507 | 38 | 63867180 |
Metastases to bone | 12.77 | 10.44 | 133 | 631381 | 20302 | 63846916 |
Intermenstrual bleeding | 12.76 | 10.44 | 90 | 631424 | 5035 | 63862183 |
Erectile dysfunction | 12.71 | 10.44 | 72 | 631442 | 12555 | 63854663 |
Nasal congestion | 12.70 | 10.44 | 710 | 630804 | 58948 | 63808270 |
Retching | 12.68 | 10.44 | 215 | 631299 | 15041 | 63852177 |
Pulmonary oedema | 12.66 | 10.44 | 635 | 630879 | 78039 | 63789179 |
Bacterial infection | 12.66 | 10.44 | 170 | 631344 | 24780 | 63842438 |
Hypertensive crisis | 12.66 | 10.44 | 250 | 631264 | 17998 | 63849220 |
Tracheal fistula | 12.59 | 10.44 | 10 | 631504 | 110 | 63867108 |
Cervicogenic headache | 12.59 | 10.44 | 6 | 631508 | 23 | 63867195 |
Fanconi syndrome acquired | 12.59 | 10.44 | 4 | 631510 | 2417 | 63864801 |
Device use issue | 12.52 | 10.44 | 43 | 631471 | 1790 | 63865428 |
Therapeutic product effect variable | 12.51 | 10.44 | 40 | 631474 | 1604 | 63865614 |
Cataract | 12.51 | 10.44 | 618 | 630896 | 50644 | 63816574 |
Tongue haematoma | 12.47 | 10.44 | 13 | 631501 | 208 | 63867010 |
Therapeutic product effect increased | 12.46 | 10.44 | 35 | 631479 | 1305 | 63865913 |
Meningitis cryptococcal | 12.40 | 10.44 | 7 | 631507 | 3002 | 63864216 |
Migraine | 12.39 | 10.44 | 741 | 630773 | 61936 | 63805282 |
Coronary arterial stent insertion | 12.38 | 10.44 | 23 | 631491 | 5669 | 63861549 |
Osteoarthritis | 12.37 | 10.44 | 748 | 630766 | 62588 | 63804630 |
Laryngeal injury | 12.34 | 10.44 | 4 | 631510 | 3 | 63867215 |
Arterial occlusive disease | 12.33 | 10.44 | 114 | 631400 | 6919 | 63860299 |
Immune effector cell-associated neurotoxicity syndrome | 12.28 | 10.44 | 5 | 631509 | 2590 | 63864628 |
Abnormal uterine bleeding | 12.26 | 10.44 | 26 | 631488 | 809 | 63866409 |
Renal tubular necrosis | 12.20 | 10.44 | 148 | 631366 | 21962 | 63845256 |
Bladder disorder | 12.19 | 10.44 | 123 | 631391 | 7644 | 63859574 |
Germ cell cancer | 12.19 | 10.44 | 11 | 631503 | 146 | 63867072 |
Hypoglycaemic unconsciousness | 12.16 | 10.44 | 31 | 631483 | 1090 | 63866128 |
Nephritic syndrome | 12.15 | 10.44 | 14 | 631500 | 252 | 63866966 |
Bundle branch block left | 12.15 | 10.44 | 151 | 631363 | 9883 | 63857335 |
Miosis | 12.11 | 10.44 | 78 | 631436 | 13188 | 63854030 |
Pneumocystis jirovecii infection | 12.10 | 10.44 | 4 | 631510 | 2357 | 63864861 |
Hair colour changes | 12.09 | 10.44 | 70 | 631444 | 3657 | 63863561 |
Femur fracture | 12.08 | 10.44 | 428 | 631086 | 33707 | 63833511 |
Drug specific antibody present | 11.95 | 10.44 | 20 | 631494 | 5134 | 63862084 |
Brain natriuretic peptide abnormal | 11.93 | 10.44 | 23 | 631491 | 667 | 63866551 |
Oesophageal achalasia | 11.93 | 10.44 | 23 | 631491 | 667 | 63866551 |
Drug level decreased | 11.90 | 10.44 | 65 | 631449 | 11438 | 63855780 |
Cytomegalovirus test positive | 11.90 | 10.44 | 20 | 631494 | 5124 | 63862094 |
Hypoalbuminaemia | 11.89 | 10.44 | 113 | 631401 | 17561 | 63849657 |
Faeces discoloured | 11.84 | 10.44 | 333 | 631181 | 25396 | 63841822 |
Granuloma | 11.82 | 10.44 | 30 | 631484 | 6611 | 63860607 |
Eye pain | 11.81 | 10.44 | 399 | 631115 | 31226 | 63835992 |
Bronchitis | 11.80 | 10.44 | 1227 | 630287 | 107516 | 63759702 |
International normalised ratio increased | 11.77 | 10.44 | 914 | 630600 | 78253 | 63788965 |
Gastrointestinal tract irritation | 11.73 | 10.44 | 20 | 631494 | 526 | 63866692 |
Urine sodium decreased | 11.73 | 10.44 | 14 | 631500 | 262 | 63866956 |
Secondary immunodeficiency | 11.72 | 10.44 | 6 | 631508 | 2718 | 63864500 |
Joint laxity | 11.72 | 10.44 | 4 | 631510 | 2310 | 63864908 |
Oedema | 11.70 | 10.44 | 1049 | 630465 | 90886 | 63776332 |
Lymph node calcification | 11.66 | 10.44 | 15 | 631499 | 304 | 63866914 |
Gene mutation | 11.64 | 10.44 | 3 | 631511 | 2079 | 63865139 |
Ocular discomfort | 11.63 | 10.44 | 73 | 631441 | 3926 | 63863292 |
Senile osteoporosis | 11.63 | 10.44 | 9 | 631505 | 95 | 63867123 |
Generalised tonic-clonic seizure | 11.62 | 10.44 | 299 | 631215 | 39558 | 63827660 |
Hypotensive transfusion reaction | 11.56 | 10.44 | 8 | 631506 | 70 | 63867148 |
Neutrophil count increased | 11.55 | 10.44 | 175 | 631339 | 24999 | 63842219 |
Gastrointestinal tract mucosal pigmentation | 11.51 | 10.44 | 27 | 631487 | 900 | 63866318 |
Upper respiratory tract inflammation | 11.51 | 10.44 | 12 | 631502 | 3770 | 63863448 |
Pulmonary haemorrhage | 11.51 | 10.44 | 78 | 631436 | 13031 | 63854187 |
Expired product administered | 11.50 | 10.44 | 99 | 631415 | 5888 | 63861330 |
Cystic fibrosis | 11.50 | 10.44 | 10 | 631504 | 3424 | 63863794 |
Pseudomembranous colitis | 11.47 | 10.44 | 19 | 631495 | 4897 | 63862321 |
Superficial vein prominence | 11.46 | 10.44 | 8 | 631506 | 71 | 63867147 |
Thyroid neoplasm | 11.45 | 10.44 | 54 | 631460 | 2603 | 63864615 |
Ecchymosis | 11.43 | 10.44 | 197 | 631317 | 13825 | 63853393 |
Metastases to lung | 11.41 | 10.44 | 95 | 631419 | 15169 | 63852049 |
Congenital central nervous system anomaly | 11.40 | 10.44 | 5 | 631509 | 15 | 63867203 |
Cystitis | 11.37 | 10.44 | 519 | 630995 | 42156 | 63825062 |
Neoplasm recurrence | 11.34 | 10.44 | 69 | 631445 | 3670 | 63863548 |
Dilatation atrial | 11.33 | 10.44 | 65 | 631449 | 3385 | 63863833 |
Sensory level abnormal | 11.31 | 10.44 | 10 | 631504 | 129 | 63867089 |
Astrocytoma | 11.27 | 10.44 | 12 | 631502 | 197 | 63867021 |
Gastric pH increased | 11.26 | 10.44 | 7 | 631507 | 50 | 63867168 |
Colorectal cancer | 11.25 | 10.44 | 9 | 631505 | 3212 | 63864006 |
Rectocele | 11.21 | 10.44 | 20 | 631494 | 546 | 63866672 |
Infection reactivation | 11.20 | 10.44 | 3 | 631511 | 2027 | 63865191 |
Vaccination site pain | 11.20 | 10.44 | 8 | 631506 | 74 | 63867144 |
Nerve compression | 11.16 | 10.44 | 117 | 631397 | 7344 | 63859874 |
Polyhydramnios | 11.15 | 10.44 | 36 | 631478 | 1451 | 63865767 |
Lichen nitidus | 11.11 | 10.44 | 8 | 631506 | 75 | 63867143 |
Multiple allergies | 11.10 | 10.44 | 96 | 631418 | 5718 | 63861500 |
Vulvovaginal discomfort | 11.08 | 10.44 | 37 | 631477 | 1518 | 63865700 |
Chromaturia | 11.08 | 10.44 | 295 | 631219 | 22316 | 63844902 |
Pharyngitis | 11.06 | 10.44 | 126 | 631388 | 18913 | 63848305 |
Vulvovaginal mycotic infection | 11.04 | 10.44 | 67 | 631447 | 3561 | 63863657 |
Eructation | 10.99 | 10.44 | 138 | 631376 | 9053 | 63858165 |
Basedow's disease | 10.99 | 10.44 | 13 | 631501 | 241 | 63866977 |
Rotator cuff repair | 10.98 | 10.44 | 36 | 631478 | 1463 | 63865755 |
Blood test abnormal | 10.97 | 10.44 | 183 | 631331 | 12760 | 63854458 |
Mean cell haemoglobin concentration increased | 10.97 | 10.44 | 24 | 631490 | 763 | 63866455 |
Oropharyngeal swelling | 10.97 | 10.44 | 31 | 631483 | 1160 | 63866058 |
Musculoskeletal discomfort | 10.96 | 10.44 | 222 | 631292 | 16055 | 63851163 |
Anaemia postoperative | 10.94 | 10.44 | 40 | 631474 | 1718 | 63865500 |
Cholecystitis chronic | 10.92 | 10.44 | 139 | 631375 | 9148 | 63858070 |
Blood potassium decreased | 10.91 | 10.44 | 492 | 631022 | 39907 | 63827311 |
Clear cell endometrial carcinoma | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Invasive papillary breast carcinoma | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Gallbladder mucocoele | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Blood proinsulin increased | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Primary hyperthyroidism | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Synovial cyst removal | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Hair growth rate abnormal | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Hypothyroidic goitre | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Tri-iodothyronine free | 10.91 | 10.44 | 3 | 631511 | 0 | 63867218 |
Chronic fatigue syndrome | 10.91 | 10.44 | 31 | 631483 | 1164 | 63866054 |
Product dispensing error | 10.88 | 10.44 | 165 | 631349 | 11285 | 63855933 |
Tinnitus | 10.88 | 10.44 | 423 | 631091 | 33710 | 63833508 |
Application site vesicles | 10.83 | 10.44 | 33 | 631481 | 1289 | 63865929 |
Injection site hypertrophy | 10.83 | 10.44 | 7 | 631507 | 54 | 63867164 |
Pituitary haemorrhage | 10.80 | 10.44 | 14 | 631500 | 286 | 63866932 |
Blood sodium decreased | 10.77 | 10.44 | 371 | 631143 | 29111 | 63838107 |
Renal cancer metastatic | 10.75 | 10.44 | 22 | 631492 | 667 | 63866551 |
Painful respiration | 10.75 | 10.44 | 59 | 631455 | 3022 | 63864196 |
Angle closure glaucoma | 10.73 | 10.44 | 53 | 631461 | 2604 | 63864614 |
Parenteral nutrition | 10.73 | 10.44 | 5 | 631509 | 18 | 63867200 |
Thyroglobulin increased | 10.72 | 10.44 | 7 | 631507 | 55 | 63867163 |
Lens disorder | 10.71 | 10.44 | 10 | 631504 | 139 | 63867079 |
Incorrect dose administered | 10.66 | 10.44 | 711 | 630803 | 60054 | 63807164 |
Delirium | 10.65 | 10.44 | 561 | 630953 | 68633 | 63798585 |
Neck injury | 10.65 | 10.44 | 48 | 631466 | 2270 | 63864948 |
Application site swelling | 10.62 | 10.44 | 21 | 631493 | 621 | 63866597 |
Multiple drug therapy | 10.60 | 10.44 | 47 | 631467 | 2207 | 63865011 |
Emotional disorder | 10.60 | 10.44 | 178 | 631336 | 12429 | 63854789 |
Recalled product | 10.59 | 10.44 | 26 | 631488 | 893 | 63866325 |
Liver injury | 10.56 | 10.44 | 218 | 631296 | 29714 | 63837504 |
Hepatic failure | 10.55 | 10.44 | 439 | 631075 | 54955 | 63812263 |
Sinus disorder | 10.53 | 10.44 | 228 | 631286 | 16680 | 63850538 |
Paternal exposure during pregnancy | 10.52 | 10.44 | 5 | 631509 | 19 | 63867199 |
Transplant failure | 10.50 | 10.44 | 13 | 631501 | 3781 | 63863437 |
Onychoclasis | 10.49 | 10.44 | 79 | 631435 | 4513 | 63862705 |
Progressive multifocal leukoencephalopathy | 10.46 | 10.44 | 121 | 631393 | 18111 | 63849107 |
Blood urea nitrogen/creatinine ratio increased | 10.45 | 10.44 | 24 | 631490 | 789 | 63866429 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Premature baby | 30.05 | 18.73 | 36 | 2237 | 3794 | 78611 |
Small for dates baby | 28.75 | 18.73 | 146 | 2127 | 2598 | 79807 |
Source | Code | Description |
---|---|---|
ATC | H03AA01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS THYROID THERAPY THYROID PREPARATIONS Thyroid hormones |
FDA CS | M0021504 | Thyroxine |
FDA EPC | N0000175945 | l-Thyroxine |
CHEBI has role | CHEBI:50671 | antithyroid drugs |
CHEBI has role | CHEBI:60311 | thyroid hormones |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:52290 | mitogens |
CHEBI has role | CHEBI:53000 | epitope role |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Goiter | indication | 3716002 | DOID:12176 |
Hashimoto thyroiditis | indication | 21983002 | |
Hypothyroidism | indication | 40930008 | DOID:1459 |
Myxedema | indication | 43153006 | DOID:11634 |
Hyperlipidemia | indication | 55822004 | DOID:1168 |
Congenital hypothyroidism | indication | 190268003 | DOID:0050328 |
Malignant tumor of thyroid gland | indication | 363478007 | DOID:1781 |
Diagnostic Test for Thyroid Dysfunction | indication | ||
Myxedema coma | off-label use | 21263006 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Thyrotoxic crisis | contraindication | 29028009 | DOID:12837 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Angina pectoris | contraindication | 194828000 | |
Osteopenia | contraindication | 312894000 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Disorder of coronary artery | contraindication | 414024009 |
Species | Use | Relation |
---|---|---|
Dogs | Replacement therapy for diminished thyroid function | Indication |
Product | Applicant | Ingredients |
---|---|---|
Thyro-Tabs Canine | Lloyd Inc. | 1 |
ThyroKare | Neogen Corp. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.08 | acidic |
pKa2 | 6.63 | acidic |
pKa3 | 8.6 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.025MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.05MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.075MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.088MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.112MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.125MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.137MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.15MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.175MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.1MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.2MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | RX | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | LEVOXYL | KING PHARMS | N021301 | May 25, 2001 | DISCN | TABLET | ORAL | 7101569 | Oct. 2, 2023 | METHOD OF USE OF ADMINISTERING LEVOTHYROXINE |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thyroid hormone receptor alpha | Nuclear hormone receptor | AGONIST | EC50 | 7.72 | CHEMBL | IUPHAR | |||
Thyroid hormone receptor beta | Nuclear hormone receptor | AGONIST | IC50 | 8.52 | IUPHAR | CHEMBL | |||
Transthyretin | Secreted | IC50 | 4.98 | CHEMBL | |||||
Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | Kd | 6.40 | CHEMBL | |||||
Retinoic acid receptor RXR-alpha | Nuclear hormone receptor | Kd | 6.03 | CHEMBL | |||||
Bile acid receptor | Nuclear hormone receptor | IC50 | 5.10 | CHEMBL | |||||
THAP domain-containing protein 1 | Unclassified | WOMBAT-PK | |||||||
Macrophage migration inhibitory factor | Unclassified | IC50 | 4.80 | CHEMBL | |||||
Malate dehydrogenase, mitochondrial | Enzyme | IC50 | 4.36 | CHEMBL | |||||
Thyroid hormone receptor beta | Transcription factor | IC50 | 7.46 | CHEMBL |
ID | Source |
---|---|
4017826 | VUID |
N0000179290 | NUI |
D01010 | KEGG_DRUG |
6106-07-6 | SECONDARY_CAS_RN |
4017826 | VANDF |
4022126 | VANDF |
CHEBI:18332 | CHEBI |
CHEMBL1624 | ChEMBL_ID |
CHEMBL2103741 | ChEMBL_ID |
CHEMBL559 | ChEMBL_ID |
CHEMBL42115 | ChEMBL_ID |
DB00451 | DRUGBANK_ID |
Q51BO43MG4 | UNII |
5819 | PUBCHEM_CID |
10582 | RXNORM |
1842 | MMSL |
4976 | MMSL |
d00278 | MMSL |
002132 | NDDF |
004881 | NDDF |
005896 | NDDF |
126202002 | SNOMEDCT_US |
38076006 | SNOMEDCT_US |
710809001 | SNOMEDCT_US |
73187006 | SNOMEDCT_US |
768532006 | SNOMEDCT_US |
783637002 | SNOMEDCT_US |
D013974 | MESH_DESCRIPTOR_UI |
C0040165 | UMLSCUI |
T44 | PDB_CHEM_ID |
453 | INN_ID |
55-03-8 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-3727 | TABLET | 137 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-4341 | TABLET | 25 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-4552 | TABLET | 50 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-5182 | TABLET | 75 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-6594 | TABLET | 88 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-6624 | TABLET | 100 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7068 | TABLET | 125 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7069 | TABLET | 150 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7070 | TABLET | 175 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7148 | TABLET | 200 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-7149 | TABLET | 300 ug | ORAL | NDA | 25 sections |
Synthroid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0074-9296 | TABLET | 112 ug | ORAL | NDA | 25 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1800 | TABLET | 25 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1803 | TABLET | 50 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1805 | TABLET | 75 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1807 | TABLET | 88 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1809 | TABLET | 100 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1811 | TABLET | 112 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1813 | TABLET | 125 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1815 | TABLET | 150 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1817 | TABLET | 175 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1819 | TABLET | 200 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1821 | TABLET | 300 ug | ORAL | ANDA | 26 sections |
Levothyroxine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1823 | TABLET | 137 ug | ORAL | ANDA | 26 sections |
UNITHROID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1370 | TABLET | 0.03 mg | ORAL | NDA | 24 sections |
UNITHROID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1371 | TABLET | 0.05 mg | ORAL | NDA | 24 sections |
UNITHROID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1372 | TABLET | 0.08 mg | ORAL | NDA | 24 sections |
UNITHROID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1373 | TABLET | 0.09 mg | ORAL | NDA | 24 sections |
UNITHROID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1374 | TABLET | 0.10 mg | ORAL | NDA | 24 sections |
UNITHROID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1375 | TABLET | 0.11 mg | ORAL | NDA | 24 sections |