levothyroxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2646 51-48-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levothyroxine sodium anhydrous
  • levothyroxine sodium pentahydrate
  • L-Thyroxine
  • thyroxin sodium
  • thyroxine sodium
  • levothyroxine sodium
  • tetraiodothyronine
  • thyroxine
  • levothyroxine
  • levothyroxin natrium
  • T4
  • levothyroxine sodium hydrate
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
  • Molecular weight: 776.87
  • Formula: C15H11I4NO4
  • CLOGP: 3.21
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 3
  • TPSA: 92.78
  • ALOGS: -4.94
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 mg O
0.15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Aug. 21, 2000 FDA STEVENS J
Jan. 23, 2020 PMDA Aska Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1281.58 10.65 45 624142 120121 49860816
Systemic lupus erythematosus 967.74 10.65 268 623919 140354 49840583
Drug ineffective 916.68 10.65 6145 618042 813188 49167749
Contraindicated product administered 897.19 10.65 357 623830 148601 49832336
Blood thyroid stimulating hormone increased 886.68 10.65 677 623510 5415 49975522
Glossodynia 880.49 10.65 177 624010 115392 49865545
Hand deformity 753.83 10.65 158 624029 100041 49880896
Treatment failure 735.41 10.65 390 623797 137247 49843690
Anti-cyclic citrullinated peptide antibody positive 678.33 10.65 50 624137 70537 49910400
Synovitis 658.73 10.65 353 623834 123512 49857425
Pericarditis 581.82 10.65 129 624058 78560 49902377
Drug intolerance 580.49 10.65 1140 623047 217964 49762973
Maternal exposure during pregnancy 561.11 10.65 687 623500 159091 49821846
Infusion related reaction 555.42 10.65 768 623419 168789 49812148
Hypothyroidism 501.86 10.65 1222 622965 32903 49948034
Arthropathy 500.53 10.65 732 623455 157174 49823763
Wound 495.06 10.65 350 623837 105444 49875493
Rheumatoid factor positive 437.26 10.65 51 624136 49808 49931129
Drug hypersensitivity 425.94 10.65 1624 622563 249386 49731551
Duodenal ulcer perforation 425.11 10.65 37 624150 45574 49935363
Therapeutic product effect decreased 411.51 10.65 651 623536 135399 49845538
Abdominal discomfort 381.84 10.65 1516 622671 230125 49750812
Off label use 378.94 10.65 3884 620303 470542 49510395
Discomfort 351.60 10.65 494 623693 107886 49873051
Swelling 349.47 10.65 1286 622901 199586 49781351
Helicobacter infection 346.77 10.65 92 624095 49610 49931327
Joint swelling 341.18 10.65 1710 622477 243576 49737361
Blood thyroid stimulating hormone abnormal 341.08 10.65 172 624015 573 49980364
Hepatic enzyme increased 333.10 10.65 751 623436 136629 49844308
Folliculitis 320.49 10.65 50 624137 39175 49941762
Lower respiratory tract infection 314.74 10.65 428 623759 94773 49886164
Muscle injury 313.18 10.65 43 624144 37068 49943869
Hyperthyroidism 279.88 10.65 523 623664 11652 49969285
Alopecia 270.91 10.65 1839 622348 243208 49737729
Blood thyroid stimulating hormone decreased 269.89 10.65 294 623893 3878 49977059
Sleep disorder due to general medical condition, insomnia type 259.39 10.65 39 624148 31408 49949529
Product use issue 248.14 10.65 975 623212 148500 49832437
Fall 246.35 10.65 5632 618555 329300 49651637
Rheumatoid arthritis 245.85 10.65 1477 622710 201073 49779864
Completed suicide 242.14 10.65 825 623362 131064 49849873
Toxicity to various agents 238.67 10.65 1587 622600 210912 49770025
Exposure during pregnancy 226.92 10.65 750 623437 120265 49860672
Hypersensitivity 221.02 10.65 1649 622538 213512 49767425
Thyroid function test abnormal 219.38 10.65 237 623950 3095 49977842
Blood thyroid stimulating hormone normal 203.58 10.65 71 624116 52 49980885
Asthenia 180.41 10.65 5181 619006 313861 49667076
Irritable bowel syndrome 172.25 10.65 229 623958 51212 49929725
Dizziness 172.08 10.65 5536 618651 340833 49640104
Infection 168.84 10.65 1344 622843 171610 49809327
Product substitution issue 159.36 10.65 457 623730 13600 49967337
Palpitations 157.34 10.65 1821 622366 92685 49888252
Pain 153.80 10.65 5718 618469 573185 49407752
Myalgia 153.16 10.65 2267 621920 122052 49858885
Drug abuse 151.67 10.65 319 623868 59527 49921410
Muscle spasms 139.91 10.65 2251 621936 123302 49857635
Rash 139.24 10.65 4222 619965 433249 49547688
Hyponatraemia 129.51 10.65 1781 622406 94358 49886579
Febrile neutropenia 129.25 10.65 692 623495 96975 49883962
Gastrointestinal disorder 125.14 10.65 669 623518 93787 49887150
Impaired healing 124.31 10.65 442 623745 69344 49911593
Drug resistance 118.36 10.65 43 624144 18946 49961991
Atrial fibrillation 117.80 10.65 1836 622351 99909 49881028
Ill-defined disorder 116.54 10.65 319 623868 54335 49926602
Blister 115.94 10.65 600 623587 84818 49896119
Feeling abnormal 112.33 10.65 2173 622014 123319 49857618
Product use in unapproved indication 111.58 10.65 903 623284 114916 49866021
Balance disorder 109.46 10.65 1342 622845 69248 49911689
Thyroid disorder 103.37 10.65 368 623819 12309 49968628
Swollen joint count increased 100.98 10.65 29 624158 14844 49966093
Stomatitis 100.92 10.65 783 623404 100561 49880376
Constipation 99.32 10.65 2996 621191 182712 49798225
Intentional overdose 99.03 10.65 415 623772 62089 49918848
Rheumatic fever 98.86 10.65 42 624145 16825 49964112
Musculoskeletal stiffness 97.08 10.65 1064 623123 127417 49853520
Red blood cell sedimentation rate abnormal 96.91 10.65 40 624147 16303 49964634
C-reactive protein abnormal 95.97 10.65 121 624066 27688 49953249
Vertigo 95.47 10.65 1019 623168 50813 49930124
Product prescribing error 95.06 10.65 510 623677 20451 49960486
Hip arthroplasty 86.88 10.65 151 624036 30278 49950659
Hepatic function abnormal 84.65 10.65 172 624015 32509 49948428
Transplant rejection 83.81 10.65 10 624177 9599 49971338
Cytomegalovirus infection 83.19 10.65 60 624127 17902 49963035
Vision blurred 83.09 10.65 1398 622789 77249 49903688
Orthostatic hypotension 82.14 10.65 634 623553 28847 49952090
Syncope 81.05 10.65 1750 622437 101252 49879685
Dysgeusia 80.72 10.65 784 623403 38132 49942805
Pyrexia 80.27 10.65 3852 620335 376351 49604586
Death 80.09 10.65 3241 620946 322138 49658799
Product complaint 79.50 10.65 316 623871 11150 49969787
Drug tolerance decreased 74.08 10.65 12 624175 9148 49971789
Nasopharyngitis 73.28 10.65 1815 622372 191112 49789825
Thyroid cancer 73.05 10.65 160 624027 4009 49976928
Disturbance in attention 72.59 10.65 644 623543 30542 49950395
Condition aggravated 71.99 10.65 2964 621223 294094 49686843
Product quality issue 71.20 10.65 636 623551 30222 49950715
Myelosuppression 71.08 10.65 39 624148 13478 49967459
Therapeutic product effect incomplete 69.85 10.65 756 623431 90759 49890178
Product formulation issue 69.44 10.65 56 624131 489 49980448
Blood calcium decreased 67.28 10.65 462 623725 20244 49960693
Intentional product use issue 66.36 10.65 617 623570 76301 49904636
Adrenocortical insufficiency acute 65.66 10.65 85 624102 1359 49979578
Psoriasis 65.54 10.65 1206 622981 67794 49913143
Dysphagia 64.86 10.65 1329 622858 76189 49904748
Tremor 64.15 10.65 1864 622323 113039 49867898
Oedema peripheral 63.35 10.65 2465 621722 155496 49825441
Therapeutic response unexpected 62.76 10.65 373 623814 15542 49965395
Therapy non-responder 62.33 10.65 371 623816 50651 49930286
Cognitive disorder 61.67 10.65 823 623364 43300 49937637
Bone marrow failure 60.57 10.65 159 624028 27465 49953472
Knee arthroplasty 60.56 10.65 232 623955 35614 49945323
Sedation complication 59.51 10.65 240 623947 8526 49972411
Pregnancy 58.40 10.65 179 624008 29398 49951539
Cardio-respiratory arrest 57.63 10.65 408 623779 53484 49927453
Autoimmune thyroiditis 57.47 10.65 126 624061 3159 49977778
Dry mouth 56.93 10.65 992 623195 55186 49925751
Craniopharyngioma 56.90 10.65 31 624156 126 49980811
Creatinine renal clearance decreased 56.56 10.65 293 623894 11588 49969349
Neutropenia 55.08 10.65 1396 622791 146569 49834368
Dehydration 54.02 10.65 2348 621839 150101 49830836
Nausea 53.61 10.65 9677 614510 695721 49285216
Insulin-like growth factor increased 53.53 10.65 58 624129 760 49980177
Panniculitis 53.43 10.65 19 624168 8484 49972453
Dry skin 53.27 10.65 788 623399 42403 49938534
Transient ischaemic attack 53.26 10.65 620 623567 31590 49949347
Reaction to excipient 52.21 10.65 68 624119 1094 49979843
Sinusitis 51.84 10.65 1655 622532 168903 49812034
Hyperhidrosis 51.37 10.65 1456 622731 87970 49892967
Weight decreased 50.28 10.65 3268 620919 217977 49762960
Nervousness 50.15 10.65 542 623645 27109 49953828
Rheumatoid nodule 49.85 10.65 50 624137 12685 49968252
Haemophagocytic lymphohistiocytosis 49.80 10.65 22 624165 8611 49972326
Visual impairment 48.36 10.65 1143 623044 67132 49913805
Malaise 47.94 10.65 4782 619405 330750 49650187
Therapeutic drug monitoring analysis not performed 47.92 10.65 51 624136 654 49980283
Hot flush 47.31 10.65 787 623400 43382 49937555
Insomnia 46.48 10.65 2619 621568 172246 49808691
Anxiety 46.04 10.65 2654 621533 174952 49805985
Neurotoxicity 45.97 10.65 69 624118 14671 49966266
Peripheral swelling 45.83 10.65 2074 622113 203862 49777075
Muscular weakness 45.51 10.65 1513 622674 93500 49887437
Enthesopathy 45.32 10.65 16 624171 7177 49973760
Product monitoring error 44.98 10.65 103 624084 2661 49978276
Thyroidectomy 44.86 10.65 58 624129 926 49980011
Myxoedema coma 44.59 10.65 38 624149 361 49980576
Blood parathyroid hormone decreased 44.52 10.65 16 624171 7098 49973839
Device difficult to use 44.52 10.65 34 624153 9852 49971085
Mucosal inflammation 43.85 10.65 302 623885 39840 49941097
Headache 43.68 10.65 6997 617190 499538 49481399
Hypoglycaemia 43.30 10.65 914 623273 52667 49928270
Transplant dysfunction 43.10 10.65 4 624183 4680 49976257
Infective pulmonary exacerbation of cystic fibrosis 42.79 10.65 22 624165 7887 49973050
Flatulence 42.64 10.65 553 623634 28905 49952032
Thyroxine free increased 42.59 10.65 51 624136 750 49980187
Arrhythmia 42.24 10.65 608 623579 32524 49948413
Device expulsion 42.23 10.65 197 623990 28625 49952312
Disease progression 41.96 10.65 882 623305 94984 49885953
Blood pressure increased 41.01 10.65 2022 622165 131110 49849827
Multiple organ dysfunction syndrome 40.77 10.65 410 623777 49927 49931010
Toxic epidermal necrolysis 40.76 10.65 128 624059 20864 49960073
Pathogen resistance 40.69 10.65 10 624177 5679 49975258
Tri-iodothyronine decreased 40.36 10.65 23 624164 104 49980833
Oral pain 40.13 10.65 479 623708 24554 49956383
Cerebral haematoma 39.95 10.65 108 624079 3103 49977834
Hepatotoxicity 39.94 10.65 186 624001 27040 49953897
Haematotoxicity 39.77 10.65 24 624163 7871 49973066
Amnesia 39.55 10.65 737 623450 41523 49939414
Therapeutic response decreased 39.39 10.65 382 623805 46849 49934088
Swollen tongue 39.17 10.65 532 623655 28098 49952839
Respiratory arrest 38.91 10.65 214 623973 29795 49951142
Diarrhoea 38.68 10.65 8016 616171 580460 49400477
Accidental exposure to product 38.45 10.65 150 624037 22907 49958030
Product solubility abnormal 38.45 10.65 47 624140 707 49980230
Thyroxine increased 38.21 10.65 41 624146 531 49980406
Gait disturbance 37.80 10.65 2236 621951 147769 49833168
Blood glucose increased 36.81 10.65 1146 623041 70178 49910759
Schizoaffective disorder 36.78 10.65 83 624104 2123 49978814
Myxoedema 36.77 10.65 20 624167 81 49980856
Anaphylactic reaction 36.41 10.65 459 623728 53596 49927341
Cardiac arrest 35.91 10.65 772 623415 82879 49898058
Venoocclusive liver disease 35.80 10.65 5 624182 4256 49976681
Sensitisation 35.17 10.65 67 624120 1515 49979422
Diffuse alopecia 35.11 10.65 40 624147 556 49980381
Live birth 34.79 10.65 96 624091 16312 49964625
Dysphonia 34.59 10.65 673 623514 38219 49942718
Pulmonary malformation 34.59 10.65 25 624162 182 49980755
C-reactive protein increased 34.50 10.65 594 623593 65880 49915057
Joint destruction 34.34 10.65 4 624183 3912 49977025
Exophthalmos 34.26 10.65 58 624129 1192 49979745
Device adhesion issue 33.99 10.65 4 624183 3881 49977056
Septic shock 33.65 10.65 499 623688 56676 49924261
Pituitary tumour recurrent 33.63 10.65 17 624170 57 49980880
Depression 33.59 10.65 2421 621766 163002 49817935
Hypersomnia 33.48 10.65 312 623875 15002 49965935
Red blood cell sedimentation rate 33.16 10.65 3 624184 3583 49977354
Post transplant lymphoproliferative disorder 32.92 10.65 6 624181 4198 49976739
Overdose 32.90 10.65 957 623230 98770 49882167
Blood thyroid stimulating hormone 32.77 10.65 11 624176 6 49980931
Unintentional medical device removal 32.72 10.65 13 624174 5422 49975515
Sickle cell anaemia with crisis 32.47 10.65 8 624179 4535 49976402
Gastrooesophageal reflux disease 32.11 10.65 1199 622988 75229 49905708
Abortion spontaneous 31.89 10.65 345 623842 41427 49939510
Thyroid hormones increased 31.34 10.65 28 624159 285 49980652
Thyroxine abnormal 30.67 10.65 9 624178 0 49980937
Milk-alkali syndrome 30.64 10.65 40 624147 645 49980292
Product administration error 30.29 10.65 374 623813 19325 49961612
Multiple-drug resistance 30.04 10.65 3 624184 3311 49977626
Bone erosion 29.85 10.65 62 624125 11625 49969312
Urinary tract infection 29.83 10.65 3178 621009 220842 49760095
Hypoacusis 29.63 10.65 387 623800 20260 49960677
Product measured potency issue 29.59 10.65 18 624169 94 49980843
Memory impairment 29.59 10.65 1229 622958 78131 49902806
Lactose intolerance 29.56 10.65 84 624103 2486 49978451
Product taste abnormal 29.48 10.65 66 624121 1679 49979258
Neutrophil count decreased 29.46 10.65 395 623792 45631 49935306
Jaw disorder 29.40 10.65 130 624057 4813 49976124
Angina pectoris 28.92 10.65 469 623718 25719 49955218
Tenosynovitis 28.75 10.65 54 624133 10511 49970426
Haematochezia 28.64 10.65 669 623518 39213 49941724
Thrombotic microangiopathy 28.55 10.65 40 624147 8751 49972186
Papillary thyroid cancer 28.38 10.65 71 624116 1944 49978993
Eye irritation 28.37 10.65 330 623857 16810 49964127
Product colour issue 28.26 10.65 35 624152 534 49980403
Suicide attempt 28.24 10.65 458 623729 51274 49929663
Papillitis 28.21 10.65 11 624176 15 49980922
Ageusia 27.89 10.65 241 623946 11342 49969595
Bone pain 27.67 10.65 771 623416 46458 49934479
Stillbirth 27.41 10.65 20 624167 5932 49975005
Full blood count abnormal 27.40 10.65 423 623764 22965 49957972
Coma 27.38 10.65 515 623672 56364 49924573
Decreased appetite 27.26 10.65 2854 621333 198069 49782868
Abdominal distension 27.18 10.65 1129 623058 71774 49909163
Adverse event 27.14 10.65 378 623809 43385 49937552
Premature baby 27.06 10.65 125 624062 18212 49962725
Fatigue 26.90 10.65 9417 614770 698184 49282753
Inner ear disorder 26.88 10.65 31 624156 437 49980500
Premature labour 26.75 10.65 64 624123 11412 49969525
Disorientation 26.65 10.65 599 623588 34885 49946052
Incorrect dose administered 26.61 10.65 784 623403 47630 49933307
Trichorrhexis 26.54 10.65 49 624138 1081 49979856
Respiratory disorder 26.53 10.65 251 623936 30936 49950001
Malabsorption 26.39 10.65 103 624084 3603 49977334
Deep vein thrombosis 26.38 10.65 1131 623056 72173 49908764
Gestational diabetes 26.32 10.65 170 624017 7295 49973642
Atrioventricular block 26.30 10.65 153 624034 6325 49974612
Bradycardia 26.17 10.65 1007 623180 63419 49917518
Disability 26.16 10.65 76 624111 12699 49968238
Cardiac disorder 26.14 10.65 705 623482 42274 49938663
Pneumocystis jirovecii pneumonia 26.01 10.65 93 624094 14570 49966367
Adenovirus infection 25.96 10.65 4 624183 3164 49977773
Eye swelling 25.81 10.65 370 623817 19774 49961163
Liver function test abnormal 25.75 10.65 723 623464 43616 49937321
Product odour abnormal 25.67 10.65 47 624140 1030 49979907
Systemic infection 25.66 10.65 74 624113 2209 49978728
Autoimmune hepatitis 25.16 10.65 169 624018 7350 49973587
Body height decreased 25.05 10.65 192 623995 8716 49972221
Impaired driving ability 24.96 10.65 106 624081 3855 49977082
Hypertension 24.95 10.65 2973 621214 208230 49772707
Hyperkalaemia 24.89 10.65 773 623414 47316 49933621
Pain in extremity 24.78 10.65 3781 620406 269084 49711853
Congenital absence of vertebra 24.70 10.65 12 624175 36 49980901
Epstein-Barr virus infection 24.61 10.65 30 624157 6967 49973970
Thyroid cancer recurrent 24.46 10.65 11 624176 26 49980911
Soft tissue disorder 24.44 10.65 110 624077 4104 49976833
Head discomfort 24.34 10.65 225 623962 10794 49970143
Scleral discolouration 24.27 10.65 26 624161 336 49980601
Muscle spasticity 24.27 10.65 119 624068 17065 49963872
Hip fracture 24.18 10.65 452 623735 25479 49955458
Foreign body in reproductive tract 24.16 10.65 30 624157 459 49980478
Dyspepsia 23.98 10.65 1131 623056 72966 49907971
Renal dysplasia 23.97 10.65 18 624169 140 49980797
Feeling cold 23.94 10.65 356 623831 19175 49961762
Presbyacusis 23.94 10.65 3 624184 2773 49978164
Therapeutic product effect increased 23.79 10.65 44 624143 972 49979965
Thyroid hormones decreased 23.72 10.65 22 624165 236 49980701
Somatic delusion 23.70 10.65 32 624155 534 49980403
Endocrine ophthalmopathy 23.63 10.65 26 624161 347 49980590
Product physical issue 23.59 10.65 111 624076 4221 49976716
Insulin-like growth factor decreased 23.57 10.65 26 624161 348 49980589
Pancreatic neuroendocrine tumour 23.51 10.65 23 624164 265 49980672
Disseminated intravascular coagulation 23.43 10.65 120 624067 17015 49963922
Paraesthesia 23.24 10.65 1753 622434 118490 49862447
Chest pain 23.07 10.65 2506 621681 174376 49806561
Low turnover osteopathy 22.98 10.65 104 624083 3890 49977047
Pulmonary tuberculosis 22.95 10.65 12 624175 4261 49976676
Skin haemorrhage 22.85 10.65 155 624032 6763 49974174
Cytomegalovirus viraemia 22.78 10.65 15 624172 4694 49976243
Acute kidney injury 22.71 10.65 3177 621010 224881 49756056
Listless 22.68 10.65 73 624114 2317 49978620
Thyroxine decreased 22.62 10.65 29 624158 459 49980478
Dementia 22.60 10.65 299 623888 15698 49965239
Pneumonia viral 22.51 10.65 153 624034 6681 49974256
Lung cyst 22.43 10.65 18 624169 156 49980781
Thyroxine free decreased 22.34 10.65 30 624157 498 49980439
Intentional self-injury 22.32 10.65 180 624007 22932 49958005
Swelling face 22.30 10.65 826 623361 51769 49929168
International normalised ratio increased 22.16 10.65 693 623494 42459 49938478
Extremity contracture 21.98 10.65 48 624139 1200 49979737
Cytokine release syndrome 21.88 10.65 46 624141 8588 49972349
Injection site reaction 21.68 10.65 461 623726 49571 49931366
Thyrotoxic periodic paralysis 21.67 10.65 9 624178 16 49980921
Choking 21.62 10.65 179 624008 8319 49972618
Blood glucose decreased 21.57 10.65 330 623857 17881 49963056
Sedation 21.53 10.65 512 623675 30098 49950839
Body temperature increased 21.52 10.65 265 623922 31076 49949861
Gastritis 21.49 10.65 546 623641 32437 49948500
Tinnitus 21.48 10.65 476 623711 27656 49953281
Graft versus host disease in skin 21.47 10.65 3 624184 2553 49978384
Chest discomfort 21.45 10.65 1372 622815 91350 49889587
Haemorrhoids 21.33 10.65 342 623845 18711 49962226
Reversible airways obstruction 21.21 10.65 42 624145 978 49979959
Abortion induced 21.08 10.65 53 624134 9291 49971646
Haematoma 21.06 10.65 509 623678 30001 49950936
Rapid eye movement sleep behaviour disorder 21.04 10.65 18 624169 172 49980765
Oral discomfort 21.00 10.65 170 624017 7847 49973090
Recalled product 20.90 10.65 49 624138 1286 49979651
Pulmonary embolism 20.89 10.65 1490 622697 100214 49880723
Drug level changed 20.59 10.65 17 624170 154 49980783
Chronic graft versus host disease 20.58 10.65 5 624182 2862 49978075
Injection site swelling 20.49 10.65 377 623810 41396 49939541
Psoriatic arthropathy 20.49 10.65 433 623754 46599 49934338
Tongue discomfort 20.47 10.65 60 624127 1808 49979129
Therapeutic product effect variable 20.44 10.65 43 624144 1047 49979890
Tooth fracture 20.29 10.65 195 623992 9456 49971481
Pituitary tumour benign 20.28 10.65 58 624129 1723 49979214
Acute graft versus host disease in skin 20.28 10.65 6 624181 3012 49977925
Ventricular hypertrophy 20.23 10.65 86 624101 3129 49977808
Diverticulum 20.16 10.65 210 623977 10404 49970533
Coronary artery occlusion 20.15 10.65 160 624027 7343 49973594
Congenital renal cyst 20.14 10.65 7 624180 5 49980932
Substance abuse 20.13 10.65 13 624174 4111 49976826
Sepsis 20.09 10.65 1390 622797 131535 49849402
Pelvic fracture 20.06 10.65 224 623963 11296 49969641
Exposure to toxic agent 20.05 10.65 10 624177 3648 49977289
Small for dates baby 19.96 10.65 91 624096 3414 49977523
Gastrointestinal motility disorder 19.96 10.65 109 624078 4400 49976537
Blood iron abnormal 19.95 10.65 8 624179 3318 49977619
Blood loss anaemia 19.94 10.65 170 624017 7969 49972968
Renal disorder 19.94 10.65 462 623725 27043 49953894
Gastrointestinal toxicity 19.92 10.65 17 624170 4660 49976277
Adenomatous polyposis coli 19.90 10.65 10 624177 33 49980904
Metastatic renal cell carcinoma 19.82 10.65 35 624152 745 49980192
Blood creatine abnormal 19.69 10.65 14 624173 99 49980838
Dry eye 19.67 10.65 527 623660 31568 49949369
Influenza like illness 19.66 10.65 882 623305 56577 49924360
Hypophysitis 19.64 10.65 53 624134 1521 49979416
Hyperlipidaemia 19.60 10.65 314 623873 17176 49963761
Disease recurrence 19.57 10.65 156 624031 19925 49961012
Foetal death 19.56 10.65 45 624142 8135 49972802
Vitamin D deficiency 19.53 10.65 221 623966 11181 49969756
Skin ulcer 19.50 10.65 312 623875 35006 49945931
Thyrotoxic crisis 19.44 10.65 34 624153 718 49980219
Metastases to bone 19.35 10.65 136 624051 17859 49963078
Lip swelling 19.35 10.65 420 623767 24316 49956621
Neuromyopathy 19.28 10.65 29 624158 537 49980400
Blood insulin increased 19.25 10.65 15 624172 124 49980813
Rhinitis allergic 19.04 10.65 153 624034 7047 49973890
Pollakiuria 18.98 10.65 406 623781 23445 49957492
Product dispensing error 18.86 10.65 180 624007 8711 49972226
Eye pain 18.85 10.65 472 623715 27977 49952960
Subdural hygroma 18.76 10.65 19 624168 229 49980708
Ejection fraction 18.74 10.65 44 624143 1156 49979781
Cardiac pacemaker insertion 18.73 10.65 92 624095 3561 49977376
Cataract 18.66 10.65 737 623450 46563 49934374
Intervertebral disc protrusion 18.51 10.65 354 623833 20039 49960898
Paradoxical drug reaction 18.49 10.65 11 624176 3636 49977301
Pharyngitis 18.47 10.65 133 624054 17370 49963567
Ecchymosis 18.29 10.65 199 623988 9970 49970967
Glomerular filtration rate decreased 18.25 10.65 222 623965 11430 49969507
Cardiotoxicity 18.18 10.65 37 624150 6990 49973947
Graft versus host disease 18.15 10.65 30 624157 6136 49974801
Tenderness 18.15 10.65 326 623861 18239 49962698
Sprue-like enteropathy 18.11 10.65 27 624160 496 49980441
Liver injury 18.09 10.65 207 623980 24599 49956338
Exposure via ingestion 18.07 10.65 6 624181 2797 49978140
Goitre 18.06 10.65 120 624067 5200 49975737
Genital swelling 18.04 10.65 14 624173 115 49980822
Drug eruption 18 10.65 195 623992 23411 49957526
Frontotemporal dementia 17.95 10.65 20 624167 271 49980666
Rectal haemorrhage 17.94 10.65 612 623575 37946 49942991
Arteriosclerosis coronary artery 17.93 10.65 158 624029 7478 49973459
Skin necrosis 17.93 10.65 71 624116 10796 49970141
Chromaturia 17.91 10.65 266 623921 14324 49966613
Arthralgia 17.89 10.65 4979 619208 433723 49547214
Spinal stenosis 17.81 10.65 250 623937 13300 49967637
No adverse event 17.76 10.65 299 623888 33279 49947658
Blood calcium increased 17.75 10.65 159 624028 7560 49973377
Oropharyngeal swelling 17.75 10.65 34 624153 772 49980165
Carpal tunnel syndrome 17.72 10.65 300 623887 16593 49964344
Persistent depressive disorder 17.71 10.65 36 624151 855 49980082
Therapy partial responder 17.66 10.65 34 624153 6557 49974380
Polycystic ovaries 17.66 10.65 69 624118 2415 49978522
Cystitis haemorrhagic 17.63 10.65 12 624175 3690 49977247
Traumatic ulcer 17.63 10.65 9 624178 31 49980906
Joint laxity 17.58 10.65 4 624183 2394 49978543
Inflammation 17.56 10.65 551 623636 56361 49924576
Hypopituitarism 17.54 10.65 36 624151 861 49980076
Lymphocyte count decreased 17.48 10.65 224 623963 26083 49954854
Ankylosing spondylitis 17.48 10.65 39 624148 7126 49973811
Muscle fatigue 17.41 10.65 64 624123 2175 49978762
Micturition urgency 17.38 10.65 167 624020 8097 49972840
Bundle branch block left 17.36 10.65 134 624053 6096 49974841
Injection site pain 17.27 10.65 1158 623029 109866 49871071
Broncholithiasis 17.24 10.65 15 624172 147 49980790
Dystonia 17.18 10.65 82 624105 11844 49969093
Bronchopulmonary aspergillosis 17.18 10.65 43 624144 7549 49973388
Device use error 17.06 10.65 24 624163 5242 49975695
Labelled drug-drug interaction medication error 17.02 10.65 201 623986 10276 49970661
Hypertensive crisis 17.01 10.65 242 623945 12912 49968025
Nephropathy toxic 17.01 10.65 47 624140 7982 49972955
Vessel puncture site haemorrhage 16.82 10.65 13 624174 106 49980831
Spondylolisthesis 16.80 10.65 80 624107 3057 49977880
Lymphadenectomy 16.80 10.65 36 624151 888 49980049
Fear of injection 16.78 10.65 31 624156 6072 49974865
Insulin autoimmune syndrome 16.76 10.65 11 624176 67 49980870
Dysstasia 16.75 10.65 311 623876 17508 49963429
Injection site pruritus 16.75 10.65 375 623812 40036 49940901
Head injury 16.66 10.65 401 623786 23619 49957318
Nephritic syndrome 16.66 10.65 16 624171 180 49980757
Arterial occlusive disease 16.65 10.65 109 624078 4699 49976238
Abnormal dreams 16.63 10.65 183 624004 9194 49971743
Arrhythmia neonatal 16.63 10.65 9 624178 36 49980901
Limb deformity 16.61 10.65 13 624174 3721 49977216
Cerebrovascular accident 16.60 10.65 1370 622817 93310 49887627
Supraventricular extrasystoles 16.57 10.65 94 624093 3850 49977087
Withdrawal syndrome 16.54 10.65 307 623880 17283 49963654
Tooth dislocation 16.47 10.65 8 624179 24 49980913
Full blood count decreased 16.40 10.65 376 623811 21970 49958967
Dilatation atrial 16.36 10.65 55 624132 1786 49979151
Thyroid cancer metastatic 16.26 10.65 13 624174 112 49980825
Abnormal weight gain 16.26 10.65 47 624140 1405 49979532
Neutropenic sepsis 16.17 10.65 105 624082 14042 49966895
Hiatus hernia 16.16 10.65 317 623870 18027 49962910
Anaemia postoperative 16.13 10.65 60 624127 2051 49978886
Piloerection 16.11 10.65 20 624167 306 49980631
Pneumonia aspiration 16.10 10.65 277 623910 30727 49950210
Pleural fibrosis 16.07 10.65 11 624176 3373 49977564
Anosmia 16.06 10.65 93 624094 3838 49977099
Seronegative arthritis 16.01 10.65 3 624184 2058 49978879
Speech disorder 15.98 10.65 562 623625 34986 49945951
Tension 15.95 10.65 72 624115 2690 49978247
Hair texture abnormal 15.93 10.65 88 624099 3568 49977369
Ischaemic stroke 15.93 10.65 281 623906 15667 49965270
Erythema dyschromicum perstans 15.90 10.65 10 624177 56 49980881
Labile hypertension 15.86 10.65 24 624163 447 49980490
Cerebellar haematoma 15.84 10.65 21 624166 344 49980593
Suspected suicide 15.83 10.65 26 624161 5331 49975606
Acute respiratory distress syndrome 15.80 10.65 175 624012 20924 49960013
Thinking abnormal 15.74 10.65 184 624003 9383 49971554
Product residue present 15.74 10.65 88 624099 3584 49977353
Skin toxicity 15.74 10.65 15 624172 3898 49977039
Anxiety disorder 15.73 10.65 88 624099 3585 49977352
Thyroid atrophy 15.72 10.65 7 624180 16 49980921
Product packaging issue 15.70 10.65 36 624151 931 49980006
Temperature intolerance 15.68 10.65 152 624035 7387 49973550
Gallbladder disorder 15.67 10.65 292 623895 16450 49964487
Aortic intramural haematoma 15.62 10.65 10 624177 58 49980879
International normalised ratio abnormal 15.59 10.65 73 624114 2770 49978167
Lymphoproliferative disorder 15.57 10.65 8 624179 2869 49978068
Incorrect route of product administration 15.55 10.65 151 624036 18515 49962422
Eructation 15.52 10.65 145 624042 6976 49973961
Retrograde amnesia 15.36 10.65 22 624165 389 49980548
Thyroglobulin increased 15.25 10.65 9 624178 44 49980893
Gastrointestinal tract irritation 15.17 10.65 23 624164 429 49980508
Feeling jittery 15.11 10.65 207 623980 10953 49969984
Posterior reversible encephalopathy syndrome 15.00 10.65 115 624072 14813 49966124
Neck injury 15 10.65 51 624136 1666 49979271
Temperature regulation disorder 15.00 10.65 18 624169 4209 49976728
Hair growth abnormal 14.97 10.65 67 624120 2494 49978443
Blood sodium decreased 14.96 10.65 354 623833 20793 49960144
Pituitary tumour 14.93 10.65 33 624154 832 49980105
Magnetic resonance imaging thoracic abnormal 14.90 10.65 7 624180 19 49980918
Skin abrasion 14.89 10.65 160 624027 7990 49972947
Poisoning 14.85 10.65 91 624096 12338 49968599
Lethargy 14.84 10.65 749 623438 48683 49932254
Premature delivery 14.81 10.65 204 623983 23459 49957478
Body height below normal 14.80 10.65 3 624184 1946 49978991
Urinary incontinence 14.75 10.65 454 623733 27754 49953183
Diabetes mellitus inadequate control 14.73 10.65 236 623951 12909 49968028
Transcription medication error 14.73 10.65 15 624172 182 49980755
Graft versus host disease in gastrointestinal tract 14.66 10.65 8 624179 2773 49978164
Application site erythema 14.59 10.65 101 624086 4437 49976500
Gingival disorder 14.54 10.65 78 624109 3127 49977810
Neonatal tachypnoea 14.51 10.65 9 624178 49 49980888
Gingival pain 14.48 10.65 125 624062 5881 49975056
Glycosylated haemoglobin increased 14.47 10.65 197 623990 10409 49970528
Poor quality product administered 14.46 10.65 71 624116 2748 49978189
Rectourethral fistula 14.42 10.65 8 624179 34 49980903
General physical health deterioration 14.38 10.65 1986 622201 140448 49840489
Blood growth hormone increased 14.33 10.65 22 624165 415 49980522
Aortic valve incompetence 14.28 10.65 116 624071 5360 49975577
Acute hepatic failure 14.28 10.65 124 624063 15553 49965384
Hyperchromic anaemia 14.24 10.65 8 624179 35 49980902
Poisoning deliberate 14.15 10.65 50 624137 7862 49973075
Diabetic ketoacidosis 14.15 10.65 304 623883 17568 49963369
Retinitis 14.13 10.65 3 624184 1884 49979053
Bundle branch block right 14.13 10.65 102 624085 4543 49976394
Sensation of foreign body 14.10 10.65 90 624097 3846 49977091
Labyrinthitis 14.09 10.65 59 624128 2132 49978805
Body height increased 14.09 10.65 9 624178 52 49980885
Adenoiditis 14.07 10.65 8 624179 36 49980901
Coombs positive haemolytic anaemia 13.94 10.65 19 624168 320 49980617
Scar 13.94 10.65 214 623973 11604 49969333
Hypogammaglobulinaemia 13.92 10.65 31 624156 5668 49975269
Dyspnoea exertional 13.91 10.65 769 623418 50464 49930473
Carotid artery stenosis 13.88 10.65 103 624084 4628 49976309
Oesophageal achalasia 13.84 10.65 21 624166 392 49980545
Mood altered 13.82 10.65 228 623959 12545 49968392
Thirst 13.80 10.65 196 623991 10454 49970483
Blood triglycerides increased 13.79 10.65 206 623981 11106 49969831
Electrocardiogram abnormal 13.76 10.65 149 624038 7456 49973481
Anti-thyroid antibody positive 13.72 10.65 21 624166 395 49980542
Tri-iodothyronine free decreased 13.71 10.65 18 624169 292 49980645
Retinal artery embolism 13.69 10.65 9 624178 55 49980882
Amniotic fluid volume increased 13.69 10.65 13 624174 144 49980793
Aspergillus infection 13.66 10.65 41 624146 6780 49974157
Mydriasis 13.66 10.65 76 624111 10551 49970386
Endocrine disorder 13.65 10.65 25 624162 548 49980389
Optic nerve compression 13.63 10.65 4 624183 0 49980937
Neonatal thyrotoxicosis 13.63 10.65 4 624183 0 49980937
Product dose omission issue 13.61 10.65 2520 621667 181318 49799619
Hypotensive transfusion reaction 13.58 10.65 8 624179 39 49980898
Tuberculosis 13.57 10.65 71 624116 10012 49970925
Malignant neoplasm progression 13.56 10.65 694 623493 67430 49913507
Burning sensation 13.51 10.65 688 623499 44758 49936179
Injection site erythema 13.50 10.65 771 623416 74165 49906772
Drug reaction with eosinophilia and systemic symptoms 13.48 10.65 258 623929 28166 49952771
Nephrectomy 13.46 10.65 31 624156 804 49980133
X-ray abnormal 13.45 10.65 8 624179 2644 49978293
Anaemia folate deficiency 13.43 10.65 14 624173 175 49980762
Vitello-intestinal duct remnant 13.42 10.65 8 624179 40 49980897
Varicose vein 13.41 10.65 95 624092 4205 49976732
Urine sodium decreased 13.41 10.65 13 624174 148 49980789
Hepatojugular reflux 13.40 10.65 6 624181 14 49980923
Atrioventricular block first degree 13.38 10.65 126 624061 6075 49974862
Open reduction of fracture 13.37 10.65 37 624150 1078 49979859
Musculoskeletal disorder 13.35 10.65 143 624044 17206 49963731
Anaemia vitamin B12 deficiency 13.35 10.65 19 624168 334 49980603
Impatience 13.31 10.65 19 624168 335 49980602
Weight loss poor 13.30 10.65 33 624154 899 49980038
Mucormycosis 13.30 10.65 7 624180 2476 49978461
Cushingoid 13.27 10.65 40 624147 6605 49974332
Carcinoid tumour of the stomach 13.21 10.65 13 624174 151 49980786
Mean cell haemoglobin concentration increased 13.21 10.65 22 624165 446 49980491
Pancreatitis acute 13.19 10.65 386 623801 23426 49957511
Anaemia 13.18 10.65 3404 620783 249052 49731885
Deafness transitory 13.16 10.65 3 624184 1793 49979144
Hormone level abnormal 13.15 10.65 57 624130 2092 49978845
Malignant melanoma 13.08 10.65 186 624001 9922 49971015
Hypocalcaemia 13.08 10.65 428 623759 26388 49954549
Inappropriate affect 13.05 10.65 30 624157 777 49980160
Change of bowel habit 13.04 10.65 50 624137 1734 49979203
Idiosyncratic drug reaction 13.01 10.65 28 624159 693 49980244
Hepatocellular carcinoma 12.99 10.65 54 624133 1945 49978992
Hypoglycaemic unconsciousness 12.98 10.65 28 624159 694 49980243
BK virus infection 12.86 10.65 10 624177 2871 49978066
Type 2 diabetes mellitus 12.86 10.65 324 623863 34051 49946886
Decreased bronchial secretion 12.85 10.65 9 624178 62 49980875
Overgrowth bacterial 12.85 10.65 9 624178 62 49980875
Juvenile idiopathic arthritis 12.84 10.65 10 624177 2869 49978068
Product coating issue 12.83 10.65 8 624179 44 49980893
Anal prolapse 12.80 10.65 10 624177 83 49980854
Vital capacity decreased 12.75 10.65 33 624154 923 49980014
Blood pressure orthostatic decreased 12.73 10.65 9 624178 63 49980874
Petechiae 12.69 10.65 221 623966 12291 49968646
Granulocytopenia 12.68 10.65 109 624078 5122 49975815
Immune reconstitution inflammatory syndrome 12.67 10.65 31 624156 5485 49975452
Hepatitis B reactivation 12.55 10.65 5 624182 2082 49978855
Hyperglycaemia 12.49 10.65 559 623628 35846 49945091
Basedow's disease 12.49 10.65 17 624170 286 49980651
Cardiac failure congestive 12.49 10.65 1206 622981 83176 49897761
Expired product administered 12.45 10.65 111 624076 5271 49975666
Bone formation increased 12.44 10.65 13 624174 163 49980774
Alanine aminotransferase abnormal 12.44 10.65 20 624167 4136 49976801
Respiratory tract malformation 12.43 10.65 10 624177 87 49980850
Neovascular age-related macular degeneration 12.42 10.65 12 624175 136 49980801
Tooth discolouration 12.41 10.65 31 624156 848 49980089
Lymph node calcification 12.40 10.65 15 624172 223 49980714
Femur fracture 12.37 10.65 573 623614 36891 49944046
Faeces discoloured 12.36 10.65 273 623914 15851 49965086
Melanoma recurrent 12.34 10.65 10 624177 88 49980849
Ulcer 12.33 10.65 175 624012 20025 49960912
Immunodeficiency 12.33 10.65 120 624067 14708 49966229
Electrocardiogram change 12.32 10.65 25 624162 593 49980344
Atrial septal defect 12.30 10.65 126 624061 6215 49974722
Gastrointestinal stromal tumour 12.28 10.65 32 624155 899 49980038
Parathyroid gland enlargement 12.23 10.65 7 624180 32 49980905
Trance 12.23 10.65 7 624180 32 49980905
Hydrops foetalis 12.22 10.65 18 624169 327 49980610
Intramedullary rod insertion 12.20 10.65 53 624134 1947 49978990
Lung lobectomy 12.16 10.65 10 624177 90 49980847
Pancreatic neoplasm 12.16 10.65 27 624160 683 49980254
Congenital acrochordon 12.16 10.65 8 624179 49 49980888
Drug dependence 12.13 10.65 171 624016 19588 49961349
Thyroxine free abnormal 12.12 10.65 6 624181 19 49980918
Retinal dystrophy 12.12 10.65 6 624181 19 49980918
Kidney transplant rejection 12.11 10.65 19 624168 3968 49976969
Recalled product administered 12.09 10.65 21 624166 441 49980496
Blood pressure inadequately controlled 12.09 10.65 94 624093 4286 49976651
Lupus nephritis 12.09 10.65 7 624180 2348 49978589
Groin pain 12.07 10.65 165 624022 8726 49972211
Somnolence 12.06 10.65 2130 622057 152855 49828082
Lipoma 12.06 10.65 55 624132 2064 49978873
Agitation neonatal 12.05 10.65 22 624165 481 49980456
Myositis 12.02 10.65 150 624037 7770 49973167
Vein discolouration 12.00 10.65 14 624173 200 49980737
Intervertebral disc degeneration 11.99 10.65 233 623954 13228 49967709
Thrombosis 11.98 10.65 821 623366 55012 49925925
Dactylitis 11.97 10.65 4 624183 1857 49979080
Ophthalmic vein thrombosis 11.95 10.65 12 624175 143 49980794
Renal cancer metastatic 11.94 10.65 16 624171 265 49980672
Bladder disorder 11.94 10.65 144 624043 7399 49973538
Febrile bone marrow aplasia 11.89 10.65 39 624148 6272 49974665
Lip blister 11.88 10.65 52 624135 1917 49979020
Abdominal pain upper 11.81 10.65 2184 622003 157125 49823812
Nocturia 11.78 10.65 131 624056 6599 49974338
Hypoglycaemia neonatal 11.76 10.65 31 624156 877 49980060
Disturbance in social behaviour 11.75 10.65 11 624176 2883 49978054
Arteriosclerosis 11.74 10.65 167 624020 8910 49972027
Throat clearing 11.74 10.65 37 624150 1161 49979776
Lymph node palpable 11.74 10.65 10 624177 95 49980842
Cholelithiasis 11.73 10.65 577 623610 37396 49943541
Tri-iodothyronine increased 11.72 10.65 11 624176 120 49980817
Product blister packaging issue 11.70 10.65 12 624175 147 49980790
Thrombocytopenia 11.70 10.65 1387 622800 126286 49854651
Adverse drug reaction 11.68 10.65 559 623628 54663 49926274
Foetal chromosome abnormality 11.68 10.65 6 624181 21 49980916
Lenticular opacities 11.67 10.65 13 624174 176 49980761
Aplastic anaemia 11.67 10.65 52 624135 7651 49973286
Increased tendency to bruise 11.65 10.65 171 624016 9185 49971752
Mitral valve sclerosis 11.64 10.65 11 624176 121 49980816
Blood magnesium increased 11.63 10.65 11 624176 2869 49978068
Retching 11.58 10.65 223 623964 12639 49968298
Visual acuity reduced 11.58 10.65 328 623859 19811 49961126
Follicular thyroid cancer 11.55 10.65 8 624179 54 49980883
Abdominal pain 11.52 10.65 3176 621011 233052 49747885
Cystic fibrosis 11.49 10.65 11 624176 2853 49978084
Acute lymphocytic leukaemia recurrent 11.44 10.65 5 624182 1970 49978967
Fasciotomy 11.43 10.65 4 624183 3 49980934
Gout 11.42 10.65 202 623985 11268 49969669
Barrett's oesophagus 11.42 10.65 24 624163 584 49980353
Sleep apnoea syndrome 11.39 10.65 380 623807 23488 49957449
Viral mutation identified 11.39 10.65 3 624184 1626 49979311
Therapeutic response changed 11.37 10.65 29 624158 804 49980133
Oesophagitis 11.37 10.65 230 623957 13153 49967784
Status epilepticus 11.35 10.65 108 624079 13298 49967639
Low density lipoprotein increased 11.34 10.65 113 624074 5533 49975404
Pulse abnormal 11.34 10.65 49 624138 1796 49979141
Wrist fracture 11.33 10.65 202 623985 11285 49969652
Peripheral coldness 11.29 10.65 184 624003 10099 49970838
Skin exfoliation 11.29 10.65 515 623672 33097 49947840
Visual field defect 11.29 10.65 115 624072 5664 49975273
Increased appetite 11.29 10.65 155 624032 8206 49972731
Orthostatic intolerance 11.28 10.65 32 624155 946 49979991
Localised infection 11.28 10.65 234 623953 25251 49955686
Kidney malrotation 11.28 10.65 6 624181 23 49980914
Spinal osteoarthritis 11.25 10.65 240 623947 13852 49967085
Maternal exposure timing unspecified 11.24 10.65 17 624170 3603 49977334
Eating disorder 11.22 10.65 259 623928 15150 49965787
Device related infection 11.17 10.65 184 624003 20551 49960386
Pulmonary arterial hypertension 11.15 10.65 329 623858 19990 49960947
Breast discomfort 11.11 10.65 19 624168 394 49980543
Congenital hydronephrosis 11.07 10.65 19 624168 395 49980542
Mucosal haemorrhage 11.07 10.65 28 624159 772 49980165
Energy increased 11.04 10.65 56 624131 2196 49978741
Eyelid oedema 11.01 10.65 171 624016 9295 49971642
Pancreatic enzymes increased 10.99 10.65 25 624162 643 49980294
Sinus node dysfunction 10.98 10.65 85 624102 3870 49977067
Application site swelling 10.96 10.65 21 624166 477 49980460
Deep brain stimulation 10.90 10.65 6 624181 25 49980912
Shock 10.88 10.65 184 624003 20466 49960471
Rotator cuff repair 10.87 10.65 46 624141 1670 49979267
Rib deformity 10.86 10.65 12 624175 161 49980776
Cold sweat 10.79 10.65 188 623999 10456 49970481
Starvation ketoacidosis 10.78 10.65 8 624179 61 49980876
Bone loss 10.78 10.65 63 624124 2609 49978328
Meniere's disease 10.76 10.65 13 624174 193 49980744
Gastric pH increased 10.75 10.65 7 624180 42 49980895
Histamine intolerance 10.75 10.65 7 624180 42 49980895
Dysuria 10.75 10.65 442 623745 28062 49952875
Radiotherapy 10.73 10.65 16 624171 294 49980643
Virologic failure 10.71 10.65 3 624184 1561 49979376
Product size issue 10.69 10.65 16 624171 295 49980642
Intentional underdose 10.69 10.65 44 624143 1578 49979359
Hospitalisation 10.66 10.65 708 623479 67229 49913708
Sensory level abnormal 10.66 10.65 10 624177 109 49980828

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypothyroidism 324.77 10.19 432 172504 15474 29386117
Blood thyroid stimulating hormone increased 279.07 10.19 192 172744 2913 29398678
Drug abuse 253.55 10.19 76 172860 79807 29321784
Drug ineffective 184.66 10.19 1306 171630 361864 29039727
Toxicity to various agents 178.14 10.19 478 172458 173183 29228408
Foetal exposure during pregnancy 175.52 10.19 515 172421 33352 29368239
Atrial septal defect 161.56 10.19 199 172737 6590 29395001
Off label use 135.03 10.19 1119 171817 299681 29101910
Febrile neutropenia 132.32 10.19 287 172649 111953 29289638
Craniopharyngioma 123.78 10.19 51 172885 242 29401349
Small for dates baby 103.60 10.19 116 172820 3463 29398128
Blood thyroid stimulating hormone decreased 101.09 10.19 84 172852 1714 29399877
Fatigue 98.57 10.19 2485 170451 314336 29087255
Treatment failure 87.22 10.19 54 172882 36885 29364706
Asthenia 79.25 10.19 1729 171207 213521 29188070
Blood thyroid stimulating hormone abnormal 78.66 10.19 36 172900 230 29401361
Thyroid function test abnormal 74.22 10.19 47 172889 615 29400976
Pituitary tumour benign 66.87 10.19 47 172889 739 29400852
Neutropenia 66.83 10.19 473 172463 131238 29270353
Thyroid disorder 65.10 10.19 80 172856 2642 29398949
Drug resistance 62.20 10.19 24 172912 21516 29380075
Drug dependence 57.95 10.19 25 172911 20956 29380635
Respiratory disorder neonatal 57.13 10.19 55 172881 1370 29400221
Insulin-like growth factor decreased 57.09 10.19 29 172907 240 29401351
Large for dates baby 55.27 10.19 44 172892 843 29400748
Thyroid cancer 53.54 10.19 52 172884 1310 29400281
Thyroxine free decreased 52.59 10.19 27 172909 229 29401362
Product use in unapproved indication 51.18 10.19 298 172638 86577 29315014
Patent ductus arteriosus 49.08 10.19 75 172861 3056 29398535
Insulin-like growth factor increased 46.67 10.19 44 172892 1067 29400524
Chronic pigmented purpura 45.48 10.19 19 172917 94 29401497
Infantile apnoea 44.95 10.19 39 172897 846 29400745
Hypopituitarism 44.90 10.19 53 172883 1677 29399914
Hyperthyroidism 44.66 10.19 131 172805 8477 29393114
Thyroxine decreased 44.08 10.19 19 172917 103 29401488
Adrenocortical insufficiency acute 43.83 10.19 46 172890 1274 29400317
Bradycardia neonatal 42.92 10.19 39 172897 901 29400690
Pyloric stenosis 40.02 10.19 34 172902 716 29400875
Cytomegalovirus infection 39.99 10.19 46 172890 23169 29378422
Autoimmune thyroiditis 39.69 10.19 39 172897 997 29400594
Fall 37.99 10.19 1328 171608 175850 29225741
Bone marrow failure 37.69 10.19 64 172872 27385 29374206
Intentional product misuse 37.27 10.19 93 172843 34568 29367023
Decreased appetite 35.93 10.19 1108 171828 144234 29257357
Dizziness 35.42 10.19 1400 171536 188284 29213307
Goitre 34.90 10.19 43 172893 1424 29400167
Neurotoxicity 33.61 10.19 22 172914 14591 29387000
Epiphysiolysis 33.55 10.19 15 172921 90 29401501
Hypophysitis 33.47 10.19 49 172887 1921 29399670
Tropical infectious disease 33.35 10.19 12 172924 36 29401555
Suicide attempt 33.29 10.19 96 172840 34014 29367577
Sepsis 32.82 10.19 612 172324 142070 29259521
Pituitary tumour recurrent 32.73 10.19 13 172923 55 29401536
Thyroid hormones decreased 31.64 10.19 16 172920 131 29401460
Secondary hypogonadism 31.30 10.19 20 172916 266 29401325
Infusion related reaction 31.22 10.19 141 172795 43745 29357846
Blood testosterone decreased 30.96 10.19 70 172866 3860 29397731
Ventricular septal defect 30.22 10.19 65 172871 3464 29398127
Immune reconstitution inflammatory syndrome 29.57 10.19 5 172931 7797 29393794
Graft versus host disease 29.03 10.19 10 172926 9618 29391973
Leukopenia 28.56 10.19 197 172739 55006 29346585
Macrocephaly 28.55 10.19 22 172914 401 29401190
Multiple organ dysfunction syndrome 28.50 10.19 234 172702 62882 29338709
Walking aid user 28.43 10.19 39 172897 1438 29400153
Overdose 28.34 10.19 314 172622 79505 29322086
Pneumocystis jirovecii pneumonia 28.09 10.19 34 172902 16745 29384846
Adrenal insufficiency 27.97 10.19 134 172802 10980 29390611
Pyrexia 27.95 10.19 1386 171550 286236 29115355
Potassium wasting nephropathy 27.30 10.19 13 172923 92 29401499
Diarrhoea 27.10 10.19 2277 170659 330421 29071170
Diabetes insipidus 27.06 10.19 50 172886 2384 29399207
Synovitis 27.00 10.19 15 172921 10875 29390716
Hypospadias 26.52 10.19 56 172880 2946 29398645
Bronchopulmonary aspergillosis 26.52 10.19 20 172916 12324 29389267
Substance abuse 26.51 10.19 4 172932 6783 29394808
Neoplasm recurrence 26.37 10.19 44 172892 1933 29399658
Toxic epidermal necrolysis 26.16 10.19 41 172895 18112 29383479
Haematotoxicity 26.05 10.19 4 172932 6695 29394896
Diabetic foetopathy 25.75 10.19 16 172920 202 29401389
Electrocardiogram QRS complex abnormal 25.24 10.19 18 172918 290 29401301
Pathogen resistance 25.22 10.19 8 172928 8108 29393483
Palmar-plantar erythrodysaesthesia syndrome 25.09 10.19 160 172776 14599 29386992
Myxoedema coma 24.98 10.19 17 172919 253 29401338
Dysphonia 24.96 10.19 195 172741 19001 29382590
Blood thyroid stimulating hormone normal 24.89 10.19 6 172930 0 29401591
Neonatal behavioural syndrome 24.86 10.19 13 172923 115 29401476
Thyroxine free increased 24.65 10.19 16 172920 219 29401372
Poisoning 24.44 10.19 14 172922 9979 29391612
Drug hypersensitivity 24.32 10.19 269 172667 68137 29333454
Therapeutic product effect incomplete 24.11 10.19 133 172803 39172 29362419
Cytomegalovirus viraemia 24.07 10.19 4 172932 6316 29395275
General physical health deterioration 24.04 10.19 779 172157 102078 29299513
Pulmonary valve stenosis congenital 23.85 10.19 13 172923 126 29401465
Tri-iodothyronine decreased 23.66 10.19 9 172927 33 29401558
Flatulence 23.64 10.19 181 172755 17528 29384063
Metastatic renal cell carcinoma 23.62 10.19 41 172895 1861 29399730
Newborn persistent pulmonary hypertension 23.55 10.19 12 172924 100 29401491
Selective eating disorder 23.52 10.19 38 172898 1625 29399966
Congenital mitral valve incompetence 23.06 10.19 12 172924 105 29401486
Septic shock 23.05 10.19 244 172692 62316 29339275
Aspergillus infection 22.92 10.19 17 172919 10564 29391027
Weight decreased 22.83 10.19 1090 171846 149815 29251776
Cerebral atrophy congenital 22.65 10.19 10 172926 58 29401533
Painful respiration 22.60 10.19 31 172905 1143 29400448
Dehydration 22.57 10.19 852 172084 113896 29287695
Papillary thyroid cancer 22.46 10.19 22 172914 560 29401031
Completed suicide 22.34 10.19 382 172554 89864 29311727
Contraindicated product administered 21.24 10.19 47 172889 18219 29383372
Hypoglycaemia neonatal 21.19 10.19 37 172899 1687 29399904
Granulocytopenia 21.08 10.19 80 172856 5914 29395677
Aortic aneurysm 21.04 10.19 82 172854 6138 29395453
Therapy non-responder 20.99 10.19 101 172835 30810 29370781
Pituitary apoplexy 20.89 10.19 8 172928 30 29401561
Sedation 20.89 10.19 44 172892 17361 29384230
Blood thyroid stimulating hormone 20.74 10.19 5 172931 0 29401591
Neutropenic sepsis 20.45 10.19 23 172913 11704 29389887
Coeliac disease 20.44 10.19 21 172915 567 29401024
Intentional self-injury 20.08 10.19 26 172910 12435 29389156
Growth retardation 19.97 10.19 35 172901 1601 29399990
Epstein-Barr virus infection 19.79 10.19 7 172929 6622 29394969
Drug intolerance 19.78 10.19 184 172752 48195 29353396
Tri-iodothyronine increased 19.75 10.19 8 172928 36 29401555
C-reactive protein increased 19.57 10.19 165 172771 44098 29357493
Haemangioma congenital 19.52 10.19 19 172917 480 29401111
Premature baby 19.50 10.19 170 172766 17110 29384481
Glossodynia 19.42 10.19 52 172884 3191 29398400
Hepatic function abnormal 19.38 10.19 142 172794 39117 29362474
Fractured coccyx 19.28 10.19 12 172924 152 29401439
Dermatomyositis 19.17 10.19 27 172909 1021 29400570
Pituitary tumour 19.07 10.19 19 172917 494 29401097
Dry skin 18.86 10.19 214 172722 23093 29378498
Neonatal tachypnoea 18.69 10.19 12 172924 161 29401430
Dependence on oxygen therapy 18.50 10.19 12 172924 164 29401427
Anencephaly 18.47 10.19 11 172925 128 29401463
Transplant rejection 18.45 10.19 16 172920 9196 29392395
Thyroiditis 18.25 10.19 37 172899 1891 29399700
Conduction disorder 18.24 10.19 36 172900 1804 29399787
Hyponatraemia 18.14 10.19 521 172415 67112 29334479
Hyperprolactinaemia 17.93 10.19 29 172907 1241 29400350
Hypoacusis 17.92 10.19 145 172791 14278 29387313
Infective pulmonary exacerbation of cystic fibrosis 17.91 10.19 7 172929 6229 29395362
Neonatal respiratory distress syndrome 17.90 10.19 56 172880 3754 29397837
Growth hormone deficiency 17.84 10.19 13 172923 217 29401374
Intentional overdose 17.77 10.19 142 172794 38386 29363205
Hepatotoxicity 17.64 10.19 50 172886 17817 29383774
Cortisol decreased 17.62 10.19 23 172913 808 29400783
Rhythm idioventricular 17.59 10.19 14 172922 268 29401323
Thyroxine increased 17.24 10.19 8 172928 53 29401538
Thyroid cancer metastatic 17.20 10.19 7 172929 32 29401559
Tachyarrhythmia 17.17 10.19 47 172889 2922 29398669
Cerebrovascular accident 17.06 10.19 579 172357 76332 29325259
Alanine aminotransferase increased 17.00 10.19 302 172634 70642 29330949
Drug ineffective for unapproved indication 17 10.19 36 172900 14178 29387413
Febrile bone marrow aplasia 17.00 10.19 11 172925 7340 29394251
Anti-thyroid antibody positive 16.99 10.19 8 172928 55 29401536
Haemophagocytic lymphohistiocytosis 16.84 10.19 22 172914 10482 29391109
Post procedural hypothyroidism 16.83 10.19 5 172931 6 29401585
Neonatal respiratory acidosis 16.76 10.19 8 172928 57 29401534
Tumour lysis syndrome 16.74 10.19 35 172901 13849 29387742
Anaphylactic shock 16.61 10.19 33 172903 13303 29388288
Thyroid cancer recurrent 16.59 10.19 4 172932 0 29401591
Product use issue 16.47 10.19 207 172729 51237 29350354
Neutrophil count decreased 16.42 10.19 169 172767 43398 29358193
Thyroid hormones increased 16.41 10.19 8 172928 60 29401531
Interstitial lung disease 16.40 10.19 238 172698 57480 29344111
Respiratory depression 16.38 10.19 34 172902 13489 29388102
Exposure via breast milk 16.38 10.19 33 172903 1679 29399912
Atrial fibrillation 16.36 10.19 765 172171 104881 29296710
Constipation 16.28 10.19 820 172116 113340 29288251
Total lung capacity abnormal 16.18 10.19 10 172926 125 29401466
Intercapillary glomerulosclerosis 16.08 10.19 7 172929 39 29401552
Brain natriuretic peptide abnormal 15.97 10.19 14 172922 308 29401283
Drug reaction with eosinophilia and systemic symptoms 15.94 10.19 97 172839 27895 29373696
Alveolitis 15.82 10.19 31 172905 1545 29400046
Diffuse alopecia 15.64 10.19 5 172931 9 29401582
Acute graft versus host disease in skin 15.60 10.19 4 172932 4660 29396931
Pulmonary artery stenosis 15.38 10.19 12 172924 223 29401368
Coagulation disorder neonatal 15.37 10.19 6 172930 24 29401567
Blood growth hormone increased 15.25 10.19 13 172923 275 29401316
Pseudomonas infection 15.17 10.19 25 172911 10827 29390764
Forced vital capacity decreased 15.12 10.19 19 172917 642 29400949
Urine oxalate increased 14.99 10.19 5 172931 11 29401580
Hypersomnia 14.97 10.19 111 172825 10643 29390948
Tongue movement disturbance 14.90 10.19 8 172928 75 29401516
Tracheal fistula 14.90 10.19 8 172928 75 29401516
N-terminal prohormone brain natriuretic peptide abnormal 14.87 10.19 11 172925 188 29401403
Prescribed underdose 14.87 10.19 87 172849 7699 29393892
Hypertension 14.70 10.19 828 172108 115786 29285805
Sopor 14.55 10.19 26 172910 10908 29390683
Pulmonary arterial pressure abnormal 14.53 10.19 11 172925 195 29401396
Thyroidectomy 14.53 10.19 7 172929 51 29401540
Adenovirus infection 14.52 10.19 4 172932 4443 29397148
Mucormycosis 14.47 10.19 6 172930 5152 29396439
Delirium 14.37 10.19 154 172782 39243 29362348
Epispadias 14.35 10.19 10 172926 155 29401436
Chest injury 14.16 10.19 28 172908 1405 29400186
Shoulder dystocia 14.15 10.19 6 172930 31 29401560
Product prescribing error 14.08 10.19 164 172772 17812 29383779
BK virus infection 14.00 10.19 5 172931 4702 29396889
Anaphylactic reaction 13.96 10.19 99 172837 27474 29374117
Nephropathy toxic 13.93 10.19 26 172910 10730 29390861
Tricuspid valve incompetence 13.65 10.19 90 172846 8304 29393287
Pancytopenia 13.62 10.19 376 172560 82792 29318799
Blood glucose increased 13.58 10.19 446 172490 58538 29343053
Foreign body in throat 13.57 10.19 7 172929 60 29401531
Cytopenia 13.52 10.19 23 172913 9836 29391755
Lumbar puncture 13.51 10.19 8 172928 92 29401499
Muscular weakness 13.47 10.19 466 172470 61586 29340005
Aorticopulmonary septal defect 13.43 10.19 5 172931 17 29401574
Hypersensitivity 13.38 10.19 223 172713 52680 29348911
Infection 13.35 10.19 344 172592 76407 29325184
Oxygen saturation increased 13.32 10.19 12 172924 274 29401317
Mineral deficiency 13.29 10.19 6 172930 37 29401554
Medulloblastoma recurrent 13.28 10.19 7 172929 63 29401528
Osteochondroma 13.21 10.19 5 172931 18 29401573
Myelosuppression 12.99 10.19 33 172903 12194 29389397
Mucosal inflammation 12.98 10.19 120 172816 31475 29370116
Enthesopathy 12.93 10.19 3 172933 3740 29397851
Ageusia 12.86 10.19 93 172843 8845 29392746
Urticaria 12.68 10.19 234 172702 54426 29347165
Chest discomfort 12.58 10.19 191 172745 45792 29355799
Cardiotoxicity 12.56 10.19 6 172930 4738 29396853
Lymphocyte count decreased 12.49 10.19 64 172872 19207 29382384
Fluid replacement 12.44 10.19 3 172933 0 29401591
Polyglandular autoimmune syndrome type II 12.44 10.19 3 172933 0 29401591
Tracheal pain 12.42 10.19 6 172930 44 29401547
Empty sella syndrome 12.42 10.19 6 172930 44 29401547
Drug interaction 12.36 10.19 990 171946 196395 29205196
Maternal exposure during breast feeding 12.30 10.19 27 172909 1459 29400132
Gastrooesophageal cancer 12.26 10.19 5 172931 23 29401568
Neonatal pneumothorax 12.24 10.19 4 172932 8 29401583
Brain oedema 12.21 10.19 34 172902 12186 29389405
Seroma 12.15 10.19 16 172920 567 29401024
Neonatal respiratory distress 12.03 10.19 15 172921 503 29401088
Hypotonia neonatal 11.99 10.19 24 172912 1215 29400376
Retrograde amnesia 11.93 10.19 8 172928 116 29401475
Application site erythema 11.91 10.19 33 172903 2066 29399525
Hypernatraemia 11.90 10.19 79 172857 7307 29394284
Cranial sutures widening 11.79 10.19 7 172929 81 29401510
Liposarcoma 11.76 10.19 8 172928 119 29401472
Scapula fracture 11.64 10.19 10 172926 214 29401377
Malignant melanoma stage IV 11.61 10.19 5 172931 27 29401564
Urethral valves 11.49 10.19 11 172925 272 29401319
Ankylosing spondylitis 11.49 10.19 5 172931 4171 29397420
Serotonin syndrome 11.44 10.19 58 172878 17454 29384137
Poisoning deliberate 11.42 10.19 10 172926 5721 29395870
Bronchiectasis 11.39 10.19 13 172923 6572 29395019
Thyroxine abnormal 11.37 10.19 4 172932 11 29401580
Suicidal ideation 11.37 10.19 139 172797 34577 29367014
Neonatal respiratory failure 11.36 10.19 12 172924 335 29401256
Bronchopneumopathy 11.32 10.19 13 172923 399 29401192
Neutrophil count increased 11.32 10.19 46 172890 14696 29386895
Congenital hydronephrosis 11.25 10.19 17 172919 686 29400905
C-reactive protein abnormal 11.20 10.19 13 172923 6523 29395068
Skin indentation 11.12 10.19 4 172932 12 29401579
Oral discomfort 11.08 10.19 35 172901 2358 29399233
Tenosynovitis 11.04 10.19 4 172932 3729 29397862
Toxic neuropathy 11.00 10.19 13 172923 412 29401179
Hyperparathyroidism 10.98 10.19 22 172914 1115 29400476
Agitation neonatal 10.88 10.19 21 172915 1035 29400556
Hair colour changes 10.85 10.19 27 172909 1584 29400007
Artery dissection 10.84 10.19 7 172929 95 29401496
Hypertensive nephropathy 10.82 10.19 13 172923 419 29401172
Altered state of consciousness 10.77 10.19 70 172866 19819 29381772
Condition aggravated 10.71 10.19 724 172212 145571 29256020
Blood prolactin decreased 10.62 10.19 10 172926 242 29401349
Application site inflammation 10.59 10.19 7 172929 99 29401492
Hospice care 10.58 10.19 58 172878 5010 29396581
Maternal exposure during pregnancy 10.58 10.19 50 172886 4073 29397518
Oedema peripheral 10.58 10.19 722 172214 102835 29298756
Hyperbilirubinaemia neonatal 10.56 10.19 17 172919 725 29400866
Primary hypothyroidism 10.55 10.19 5 172931 35 29401556
Subgaleal haematoma 10.55 10.19 5 172931 35 29401556
Brachydactyly 10.50 10.19 9 172927 192 29401399
Gangrene neonatal 10.50 10.19 9 172927 192 29401399
Polycythaemia 10.48 10.19 28 172908 1716 29399875
Therapy partial responder 10.45 10.19 9 172927 5190 29396401
Incarcerated umbilical hernia 10.45 10.19 4 172932 15 29401576
Cervicogenic headache 10.45 10.19 4 172932 15 29401576
Wrong schedule 10.42 10.19 8 172928 145 29401446
Thrombocytopenia 10.42 10.19 664 172272 134159 29267432
Moaning 10.40 10.19 17 172919 734 29400857
Lip blister 10.40 10.19 15 172921 580 29401011
CNS germinoma 10.38 10.19 3 172933 3 29401588
Follicular thyroid cancer 10.38 10.19 3 172933 3 29401588
Gait inability 10.38 10.19 158 172778 18217 29383374
Blood glucose decreased 10.31 10.19 112 172824 11957 29389634
Pseudolymphoma 10.27 10.19 14 172922 513 29401078
Congenital hypothyroidism 10.25 10.19 4 172932 16 29401575
Wrong patient received product 10.23 10.19 33 172903 2249 29399342
Extrapyramidal disorder 10.19 10.19 31 172905 10800 29390791

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood thyroid stimulating hormone increased 750.49 10.44 613 630901 7041 63860177
Hypothyroidism 654.83 10.44 1311 630203 39146 63828072
Drug ineffective 579.20 10.44 5355 626159 834892 63032326
Toxicity to various agents 483.43 10.44 1877 629637 361636 63505582
Drug abuse 455.45 10.44 376 631138 131998 63735220
Pemphigus 418.33 10.44 51 631463 60650 63806568
Off label use 398.23 10.44 4120 627394 628686 63238532
Treatment failure 351.05 10.44 375 631139 116441 63750777
Febrile neutropenia 336.79 10.44 845 630669 186812 63680406
Anti-cyclic citrullinated peptide antibody positive 331.04 10.44 46 631468 49516 63817702
Synovitis 329.15 10.44 291 631223 98799 63768419
Contraindicated product administered 326.41 10.44 344 631170 107485 63759733
Fall 294.63 10.44 5721 625793 411105 63456113
Drug intolerance 281.22 10.44 923 630591 187069 63680149
Infusion related reaction 275.00 10.44 767 630747 163700 63703518
Systemic lupus erythematosus 274.96 10.44 214 631300 77398 63789820
Hand deformity 273.65 10.44 136 631378 62635 63804583
Completed suicide 269.16 10.44 1205 630309 223209 63644009
Blood thyroid stimulating hormone decreased 258.92 10.44 287 631227 4943 63862275
Pericarditis 245.76 10.44 154 631360 62362 63804856
Blood thyroid stimulating hormone normal 226.68 10.44 73 631441 52 63867166
Glossodynia 225.87 10.44 181 631333 64515 63802703
Hyperthyroidism 215.57 10.44 520 630994 17659 63849559
Drug resistance 209.32 10.44 44 631470 35058 63832160
Duodenal ulcer perforation 205.24 10.44 44 631470 34581 63832637
Drug hypersensitivity 199.01 10.44 1436 630078 236379 63630839
Rheumatoid factor positive 194.08 10.44 51 631463 34887 63832331
Asthenia 190.88 10.44 5513 626001 422531 63444687
Product use in unapproved indication 176.02 10.44 1011 630503 175607 63691611
Blood thyroid stimulating hormone abnormal 174.24 10.44 102 631412 644 63866574
Dizziness 174.19 10.44 5475 626039 424688 63442530
Therapeutic product effect decreased 169.89 10.44 570 630944 114781 63752437
Thyroid function test abnormal 169.09 10.44 173 631341 2706 63864512
Palpitations 163.96 10.44 1654 629860 102834 63764384
Arthropathy 163.34 10.44 620 630894 120347 63746871
Folliculitis 152.37 10.44 52 631462 30025 63837193
Helicobacter infection 148.71 10.44 96 631418 38266 63828952
Muscle injury 147.98 10.44 38 631476 26399 63840819
Neutropenia 145.97 10.44 1570 629944 238054 63629164
Cytomegalovirus infection 145.69 10.44 92 631422 37107 63830111
Sleep disorder due to general medical condition, insomnia type 144.68 10.44 39 631475 26231 63840987
Fatigue 142.58 10.44 8814 622700 739916 63127302
Thyroid disorder 133.89 10.44 330 631184 11362 63855856
Pyrexia 133.29 10.44 4312 627202 554332 63312886
Muscle spasms 133.07 10.44 2029 629485 138994 63728224
Lower respiratory tract infection 132.92 10.44 477 631037 94137 63773081
Hyponatraemia 130.02 10.44 2108 629406 146231 63720987
Hepatic enzyme increased 129.33 10.44 744 630770 129199 63738019
Headache 127.26 10.44 6369 625145 523098 63344120
Hepatic function abnormal 123.68 10.44 279 631235 64034 63803184
Craniopharyngioma 120.39 10.44 64 631450 325 63866893
Wound 119.49 10.44 368 631146 76109 63791109
Multiple organ dysfunction syndrome 116.42 10.44 553 630961 100860 63766358
Balance disorder 115.49 10.44 1294 630220 82632 63784586
Maternal exposure during pregnancy 114.72 10.44 515 630999 95369 63771849
Bone marrow failure 114.15 10.44 183 631331 47769 63819449
Transplant rejection 111.94 10.44 18 631496 17383 63849835
Infection 111.86 10.44 1213 630301 183667 63683551
Myalgia 111.60 10.44 2177 629337 156440 63710778
Intentional overdose 108.87 10.44 481 631033 89463 63777755
Joint swelling 107.23 10.44 1474 630040 213908 63653310
Hypersensitivity 101.94 10.44 1333 630181 195119 63672099
Vertigo 100.29 10.44 950 630564 58061 63809157
Death 99.57 10.44 3793 627721 478912 63388306
Nausea 98.18 10.44 8947 622567 776853 63090365
Product substitution issue 96.92 10.44 389 631125 17472 63849746
Feeling abnormal 92.72 10.44 1830 629684 131772 63735446
Discomfort 90.51 10.44 445 631069 80433 63786785
Product prescribing error 90.00 10.44 623 630891 34646 63832572
Constipation 87.11 10.44 2898 628616 226439 63640779
Septic shock 86.95 10.44 639 630875 104798 63762420
Sepsis 86.54 10.44 1661 629853 228680 63638538
Myelosuppression 84.00 10.44 66 631448 23764 63843454
Product quality issue 83.02 10.44 538 630976 29261 63837957
Product use issue 82.19 10.44 1020 630494 150695 63716523
Adrenocortical insufficiency acute 82.07 10.44 113 631401 2452 63864766
Sedation complication 81.61 10.44 255 631259 10099 63857119
Creatinine renal clearance decreased 80.59 10.44 317 631197 14104 63853114
Thyroid cancer 80.31 10.44 142 631372 3849 63863369
Overdose 79.03 10.44 1093 630421 158473 63708745
Cardiac arrest 78.94 10.44 1048 630466 153016 63714202
Neurotoxicity 77.87 10.44 92 631422 27312 63839906
Cardio-respiratory arrest 77.02 10.44 605 630909 97788 63769430
Toxic epidermal necrolysis 75.80 10.44 156 631358 37010 63830208
Acute graft versus host disease 75.78 10.44 3 631511 9081 63858137
Haemophagocytic lymphohistiocytosis 75.46 10.44 39 631475 17570 63849648
Pathogen resistance 74.21 10.44 16 631498 12527 63854691
Vision blurred 73.41 10.44 1268 630246 89048 63778170
Orthostatic hypotension 73.34 10.44 740 630774 45998 63821220
Venoocclusive liver disease 72.59 10.44 7 631507 10008 63857210
Blood calcium decreased 72.20 10.44 463 631051 25091 63842127
Therapy non-responder 70.65 10.44 368 631146 65531 63801687
Product complaint 69.44 10.44 266 631248 11688 63855530
Respiratory arrest 68.65 10.44 276 631238 52709 63814509
Post transplant lymphoproliferative disorder 68.31 10.44 7 631507 9537 63857681
C-reactive protein abnormal 68.05 10.44 112 631402 28935 63838283
Neutrophil count decreased 67.97 10.44 459 631055 76737 63790481
Cognitive disorder 67.19 10.44 830 630684 54257 63812961
Dry mouth 66.80 10.44 894 630620 59524 63807694
Dysgeusia 65.89 10.44 728 630786 46319 63820899
Red blood cell sedimentation rate abnormal 65.70 10.44 39 631475 16267 63850951
Insulin-like growth factor increased 65.67 10.44 81 631433 1571 63865647
Irritable bowel syndrome 65.61 10.44 170 631344 37199 63830019
Haematotoxicity 64.11 10.44 23 631491 12873 63854345
Pneumocystis jirovecii pneumonia 62.49 10.44 109 631405 27525 63839693
Pituitary tumour benign 61.63 10.44 93 631421 2200 63865018
Myxoedema coma 61.08 10.44 52 631462 635 63866583
Autoimmune thyroiditis 60.29 10.44 117 631397 3411 63863807
Bronchopulmonary aspergillosis 59.86 10.44 59 631455 19026 63848192
Cytomegalovirus viraemia 59.77 10.44 16 631498 10812 63856406
Product formulation issue 59.76 10.44 56 631458 782 63866436
Respiratory failure 59.37 10.44 1166 630348 160017 63707201
Syncope 59.05 10.44 1989 629525 155646 63711572
Swelling 58.72 10.44 1160 630354 159058 63708160
Hepatotoxicity 58.44 10.44 198 631316 39764 63827454
Dry skin 58.21 10.44 761 630753 50400 63816818
Urinary tract infection 58.13 10.44 2799 628715 228797 63638421
Thrombocytopenia 57.89 10.44 1708 629806 222093 63645125
Atrial fibrillation 57.46 10.44 2132 629382 168957 63698261
Disturbance in attention 57.26 10.44 635 630879 40439 63826779
Substance abuse 56.74 10.44 11 631503 9281 63857937
Cystitis haemorrhagic 56.52 10.44 6 631508 7950 63859268
Rheumatoid arthritis 56.21 10.44 1203 630311 163091 63704127
Enthesopathy 55.60 10.44 13 631501 9625 63857593
Diarrhoea 55.47 10.44 7975 623539 714729 63152489
Infective pulmonary exacerbation of cystic fibrosis 53.79 10.44 24 631490 11772 63855446
Psoriasis 53.76 10.44 994 630520 70709 63796509
Thyroxine free increased 53.51 10.44 60 631454 1047 63866171
Suicide attempt 52.64 10.44 443 631071 70564 63796654
Pain in extremity 51.88 10.44 3538 627976 299547 63567671
Graft versus host disease 51.60 10.44 36 631478 13777 63853441
Abdominal discomfort 51.60 10.44 1374 630140 180948 63686270
Dehydration 51.53 10.44 2606 628908 214157 63653061
Drug dependence 51.52 10.44 161 631353 33151 63834067
Multiple-drug resistance 51.50 10.44 3 631511 6499 63860719
Hot flush 51.05 10.44 684 630830 45551 63821667
Mucosal inflammation 50.76 10.44 381 631133 62203 63805015
C-reactive protein increased 50.66 10.44 640 630874 94269 63772949
Aspergillus infection 49.81 10.44 52 631462 16327 63850891
Flatulence 49.08 10.44 550 630964 35116 63832102
Pancytopenia 48.82 10.44 1050 630464 142259 63724959
Epstein-Barr virus infection 48.74 10.44 31 631483 12457 63854761
Diffuse alopecia 48.53 10.44 43 631471 556 63866662
Thyroxine free decreased 48.32 10.44 50 631464 793 63866425
Papillary thyroid cancer 47.85 10.44 83 631431 2215 63865003
Adenovirus infection 47.82 10.44 7 631507 7248 63859970
Intentional product use issue 47.63 10.44 652 630862 94712 63772506
Disseminated intravascular coagulation 47.49 10.44 160 631354 32188 63835030
Transient ischaemic attack 47.30 10.44 650 630864 43532 63823686
Gastrointestinal disorder 47.11 10.44 607 630907 89102 63778116
Insulin-like growth factor decreased 47.10 10.44 41 631473 517 63866701
Oedema peripheral 47.04 10.44 2514 629000 207803 63659415
Pituitary tumour recurrent 46.90 10.44 24 631490 111 63867107
Reaction to excipient 46.69 10.44 63 631451 1340 63865878
Chronic graft versus host disease 46.52 10.44 4 631510 6272 63860946
Thyroidectomy 46.21 10.44 48 631466 765 63866453
Blood thyroid stimulating hormone 45.97 10.44 14 631500 6 63867212
Immune reconstitution inflammatory syndrome 45.93 10.44 33 631481 12437 63854781
Hypertension 45.87 10.44 3035 628479 256226 63610992
Gait disturbance 45.82 10.44 2093 629421 170062 63697156
Therapeutic response unexpected 44.97 10.44 303 631211 16698 63850520
Oral pain 44.92 10.44 439 631075 27054 63840164
Dysphonia 44.73 10.44 670 630844 45712 63821506
Cytokine release syndrome 44.56 10.44 85 631429 20744 63846474
Thrombotic microangiopathy 44.10 10.44 59 631455 16596 63850622
Tri-iodothyronine decreased 43.81 10.44 26 631488 169 63867049
Sensitisation 43.43 10.44 68 631446 1663 63865555
Rheumatoid nodule 43.39 10.44 36 631478 12615 63854603
Product monitoring error 42.69 10.44 134 631380 5320 63861898
Malaise 42.50 10.44 4466 627048 391781 63475437
Muscular weakness 41.82 10.44 1583 629931 125755 63741463
Ill-defined disorder 41.80 10.44 256 631258 43796 63823422
Therapeutic response decreased 41.72 10.44 319 631195 51869 63815349
General physical health deterioration 41.69 10.44 2423 629091 202002 63665216
Nephropathy toxic 41.53 10.44 67 631447 17447 63849771
Therapeutic drug monitoring analysis not performed 41.22 10.44 55 631459 1157 63866061
Graft versus host disease in skin 40.78 10.44 3 631511 5344 63861874
Gestational diabetes 40.72 10.44 134 631380 5456 63861762
Panniculitis 40.59 10.44 18 631496 8861 63858357
Anaphylactic reaction 40.49 10.44 453 631061 68211 63799007
Poisoning 40.38 10.44 97 631417 21782 63845436
Drug reaction with eosinophilia and systemic symptoms 40.29 10.44 338 631176 53879 63813339
Insomnia 39.98 10.44 2343 629171 195493 63671725
Stomatitis 39.11 10.44 797 630717 108808 63758410
Thyroid hormones decreased 39.07 10.44 29 631485 286 63866932
Swollen tongue 38.96 10.44 518 630996 34436 63832782
Thyroid cancer recurrent 38.89 10.44 13 631501 12 63867206
Tremor 38.12 10.44 1796 629718 146434 63720784
Abdominal pain upper 38.09 10.44 2087 629427 172943 63694275
Acute graft versus host disease in skin 38.08 10.44 10 631504 6845 63860373
Pneumonia 37.75 10.44 4851 626663 554725 63312493
Dystonia 36.95 10.44 81 631433 18784 63848434
Cytomegalovirus infection reactivation 36.92 10.44 6 631508 5750 63861468
Transplant dysfunction 36.86 10.44 10 631504 6698 63860520
Tumour lysis syndrome 36.83 10.44 85 631429 19355 63847863
Weight decreased 36.73 10.44 3262 628252 282477 63584741
Condition aggravated 36.68 10.44 3143 628371 369283 63497935
Mucormycosis 36.65 10.44 13 631501 7328 63859890
Polyomavirus-associated nephropathy 36.55 10.44 3 631511 4885 63862333
Neutropenic sepsis 36.32 10.44 112 631402 23160 63844058
Interstitial lung disease 35.96 10.44 707 630807 97025 63770193
Dysphagia 35.83 10.44 1331 630183 105481 63761737
Graft versus host disease in gastrointestinal tract 35.66 10.44 6 631508 5606 63861612
Acute myeloid leukaemia 35.61 10.44 143 631371 27320 63839898
BK virus infection 35.54 10.44 14 631500 7398 63859820
Sickle cell anaemia with crisis 35.48 10.44 5 631509 5327 63861891
Hypophysitis 35.13 10.44 95 631419 3464 63863754
Therapeutic product effect incomplete 35.00 10.44 759 630755 102723 63764495
Gastrooesophageal reflux disease 35.00 10.44 1064 630450 82079 63785139
Dyspepsia 34.68 10.44 1031 630483 79281 63787937
Thyroid hormones increased 34.53 10.44 28 631486 318 63866900
Exposure during pregnancy 34.29 10.44 544 630970 77131 63790087
Hip fracture 34.21 10.44 411 631103 26688 63840530
Device adhesion issue 34.19 10.44 5 631509 5181 63862037
Cytomegalovirus chorioretinitis 34.15 10.44 4 631510 4908 63862310
Impaired healing 33.69 10.44 404 631110 60069 63807149
Anxiety 33.48 10.44 2359 629155 200290 63666928
Amnesia 33.39 10.44 661 630853 47608 63819610
Hypopituitarism 33.35 10.44 78 631436 2595 63864623
Nervousness 33.35 10.44 439 631075 29117 63838101
Tenosynovitis 33.32 10.44 40 631474 11793 63855425
Coma 32.79 10.44 632 630882 86983 63780235
Decreased appetite 32.37 10.44 3186 628328 278103 63589115
Bone pain 32.09 10.44 649 630865 46923 63820295
Blood parathyroid hormone decreased 32.03 10.44 16 631498 7350 63859868
Thyroxine increased 31.94 10.44 36 631478 632 63866586
Carpal tunnel syndrome 31.61 10.44 264 631250 15564 63851654
Trichorrhexis 31.39 10.44 37 631477 683 63866535
Ageusia 31.20 10.44 237 631277 13576 63853642
Pulmonary tuberculosis 31.10 10.44 16 631498 7228 63859990
Lymphocyte count decreased 31.03 10.44 252 631262 40447 63826771
Myxoedema 30.96 10.44 18 631496 112 63867106
Pseudomonas infection 30.90 10.44 82 631432 17801 63849417
Disease progression 30.71 10.44 1106 630408 140574 63726644
Metastatic renal cell carcinoma 30.65 10.44 67 631447 2129 63865089
Musculoskeletal stiffness 30.41 10.44 946 630568 122260 63744958
Unintentional medical device removal 30.24 10.44 14 631500 6720 63860498
Blood pressure increased 29.96 10.44 2017 629497 170535 63696683
Chronic pigmented purpura 29.85 10.44 20 631494 165 63867053
Respiratory depression 29.81 10.44 123 631391 23320 63843898
Aplastic anaemia 29.61 10.44 57 631457 13863 63853355
Epiphysiolysis 29.53 10.44 16 631498 85 63867133
Acute respiratory distress syndrome 29.26 10.44 242 631272 38693 63828525
Drug tolerance decreased 29.25 10.44 16 631498 6982 63860236
Full blood count abnormal 29.14 10.44 431 631083 29326 63837892
Accidental exposure to product 28.94 10.44 146 631368 26218 63841000
Body height decreased 28.63 10.44 148 631366 7406 63859812
Nocardiosis 28.37 10.44 6 631508 4761 63862457
Thyroxine decreased 28.26 10.44 33 631481 603 63866615
Feeling cold 28.11 10.44 355 631159 23323 63843895
Influenza like illness 27.98 10.44 797 630717 60905 63806313
Drug ineffective for unapproved indication 27.95 10.44 184 631330 30949 63836269
Myelodysplastic syndrome 27.90 10.44 157 631357 27422 63839796
Drug eruption 27.89 10.44 223 631291 35913 63831305
Foreign body in reproductive tract 27.62 10.44 28 631486 433 63866785
Tropical infectious disease 27.35 10.44 12 631502 36 63867182
Papillitis 27.05 10.44 13 631501 51 63867167
Polycystic ovaries 27.02 10.44 63 631451 2092 63865126
Burning sensation 27.00 10.44 657 630857 49007 63818211
Status epilepticus 26.72 10.44 115 631399 21548 63845670
Product taste abnormal 26.71 10.44 60 631454 1943 63865275
Oral discomfort 26.70 10.44 157 631357 8249 63858969
Memory impairment 26.44 10.44 1058 630456 84624 63782594
Pulmonary malformation 26.31 10.44 17 631497 131 63867087
Hypersomnia 26.20 10.44 302 631212 19415 63847803
Bone erosion 25.98 10.44 46 631468 11549 63855669
Swelling face 25.94 10.44 761 630753 58405 63808813
Tenderness 25.94 10.44 300 631214 19302 63847916
Hip arthroplasty 25.93 10.44 114 631400 21237 63845981
Bacteraemia 25.73 10.44 156 631358 26755 63840463
Rash 25.65 10.44 4020 627494 454529 63412689
Device difficult to use 25.65 10.44 35 631479 9763 63857455
Dry eye 25.61 10.44 413 631101 28606 63838612
Alanine aminotransferase increased 25.43 10.44 1107 630407 137924 63729294
Product physical issue 25.41 10.44 83 631431 3366 63863852
Granulocytopenia 25.22 10.44 182 631332 10258 63856960
Goitre 25.16 10.44 106 631408 4867 63862351
Visual impairment 25.06 10.44 924 630590 73153 63794065
Product dose omission issue 24.96 10.44 2223 629291 192524 63674694
Ejection fraction 24.91 10.44 45 631469 1241 63865977
Paraesthesia 24.88 10.44 1581 629933 132941 63734277
Blister 24.81 10.44 603 630911 80364 63786854
Altered state of consciousness 24.80 10.44 244 631270 37658 63829560
Tri-iodothyronine increased 24.80 10.44 18 631496 171 63867047
Weight increased 24.75 10.44 2418 629096 210930 63656288
Cardiotoxicity 24.64 10.44 39 631475 10235 63856983
Jaw disorder 24.60 10.44 100 631414 4517 63862701
Poisoning deliberate 24.57 10.44 60 631454 13398 63853820
Somatic delusion 24.53 10.44 32 631482 658 63866560
Head discomfort 24.50 10.44 199 631315 11635 63855583
Hypoglycaemia 24.36 10.44 1095 630419 88797 63778421
Eye swelling 24.34 10.44 329 631185 21952 63845266
Platelet count decreased 24.14 10.44 1369 630145 166342 63700876
Lipodystrophy acquired 24.10 10.44 5 631509 4022 63863196
Autoimmune hepatitis 23.90 10.44 175 631339 9909 63857309
Secondary hypogonadism 23.77 10.44 23 631491 335 63866883
Diverticulum 23.69 10.44 215 631299 12983 63854235
Virologic failure 23.66 10.44 3 631511 3463 63863755
Haemorrhoids 23.64 10.44 348 631166 23653 63843565
Myocardial infarction 23.61 10.44 1355 630159 164466 63702752
Red blood cell sedimentation rate 23.54 10.44 4 631510 3710 63863508
Product colour issue 23.51 10.44 30 631484 603 63866615
Febrile bone marrow aplasia 23.15 10.44 47 631467 11208 63856010
Enterococcal infection 22.89 10.44 65 631449 13801 63853417
Cardiogenic shock 22.83 10.44 205 631309 32222 63834996
Gallbladder disorder 22.70 10.44 261 631253 16769 63850449
Arrhythmia 22.67 10.44 679 630835 52265 63814953
Therapy partial responder 22.65 10.44 41 631473 10207 63857011
Intentional self-injury 22.52 10.44 179 631335 28865 63838353
Endocrine ophthalmopathy 22.50 10.44 24 631490 395 63866823
Leukopenia 22.47 10.44 788 630726 100454 63766764
Sciatica 22.45 10.44 300 631214 19964 63847254
Blood glucose increased 22.44 10.44 1175 630339 96898 63770320
Hypoacusis 22.40 10.44 367 631147 25500 63841718
Inner ear disorder 22.35 10.44 27 631487 512 63866706
Retrograde amnesia 22.35 10.44 26 631488 473 63866745
Exposure via ingestion 22.31 10.44 10 631504 4892 63862326
Acute lymphocytic leukaemia recurrent 22.13 10.44 6 631508 4020 63863198
Labyrinthitis 21.98 10.44 66 631448 2557 63864661
Ankylosing spondylitis 21.97 10.44 29 631485 8205 63859013
Pneumonia fungal 21.96 10.44 33 631481 8844 63858374
Hypoxia 21.95 10.44 676 630838 87473 63779745
Posterior reversible encephalopathy syndrome 21.95 10.44 133 631381 22813 63844405
Product odour abnormal 21.89 10.44 40 631474 1113 63866105
Head injury 21.80 10.44 447 631067 32395 63834823
Exposure to toxic agent 21.78 10.44 17 631497 6142 63861076
Tongue discomfort 21.70 10.44 57 631457 2042 63865176
Haematoma 21.69 10.44 600 630914 45650 63821568
Metabolic acidosis 21.59 10.44 529 630985 70429 63796789
Paradoxical drug reaction 21.51 10.44 17 631497 6103 63861115
Cerebral infarction 21.44 10.44 278 631236 40766 63826452
Cerebrovascular accident 21.24 10.44 1593 629921 135990 63731228
Pneumonia cytomegaloviral 21.13 10.44 8 631506 4331 63862887
Spinal stenosis 21.10 10.44 219 631295 13712 63853506
Drug use disorder 21.04 10.44 17 631497 6037 63861181
Scleral discolouration 21.01 10.44 26 631488 506 63866712
Lip blister 21.01 10.44 59 631455 2200 63865018
Pelvic fracture 21.00 10.44 176 631338 10387 63856831
Skin necrosis 20.94 10.44 71 631443 14258 63852960
Skin haemorrhage 20.93 10.44 150 631364 8435 63858783
Malabsorption 20.85 10.44 92 631422 4311 63862907
Lymphoproliferative disorder 20.85 10.44 12 631502 5091 63862127
Diffuse large B-cell lymphoma recurrent 20.82 10.44 3 631511 3143 63864075
Blood growth hormone increased 20.81 10.44 28 631486 594 63866624
Staphylococcal infection 20.70 10.44 360 631154 50318 63816900
Respiratory disorder 20.59 10.44 240 631274 35871 63831347
Adrenal insufficiency 20.59 10.44 322 631192 22165 63845053
Nasopharyngitis 20.58 10.44 1646 629868 194427 63672791
Drug abuser 20.58 10.44 16 631498 5792 63861426
Disorientation 20.52 10.44 703 630811 55125 63812093
Lip swelling 20.44 10.44 432 631082 31475 63835743
Viral mutation identified 20.35 10.44 4 631510 3342 63863876
Atrioventricular block 20.19 10.44 193 631321 11822 63855396
Kidney transplant rejection 20.18 10.44 39 631475 9472 63857746
Serotonin syndrome 20.17 10.44 267 631247 39015 63828203
Lymphadenectomy 20.15 10.44 36 631478 984 63866234
Disease recurrence 20.14 10.44 204 631310 31306 63835912
Renal impairment 20.00 10.44 1099 630415 133918 63733300
Intentional product misuse 19.86 10.44 547 630967 71748 63795470
Medulloblastoma recurrent 19.83 10.44 13 631501 103 63867115
Reversible airways obstruction 19.76 10.44 38 631476 1100 63866118
Anti-thyroid antibody positive 19.75 10.44 24 631490 458 63866760
Alanine aminotransferase abnormal 19.70 10.44 23 631491 6865 63860353
Milk-alkali syndrome 19.70 10.44 39 631475 1154 63866064
Haematochezia 19.65 10.44 816 630698 65557 63801661
Choking 19.59 10.44 173 631341 10365 63856853
Diabetes insipidus 19.57 10.44 92 631422 4429 63862789
Hypogammaglobulinaemia 19.53 10.44 45 631469 10254 63856964
Cardiac disorder 19.31 10.44 698 630816 55118 63812100
Pre-existing condition improved 19.24 10.44 95 631419 4667 63862551
Intervertebral disc protrusion 19.20 10.44 291 631223 19900 63847318
Cytopenia 19.16 10.44 82 631432 15389 63851829
Juvenile idiopathic arthritis 19.14 10.44 7 631507 3872 63863346
Medullary thyroid cancer 19.12 10.44 14 631500 135 63867083
Thyrotoxic crisis 19.06 10.44 37 631477 1079 63866139
Poor quality product administered 19.05 10.44 72 631442 3143 63864075
Blood cholesterol increased 19.05 10.44 633 630881 49433 63817785
Skin toxicity 18.93 10.44 22 631492 6580 63860638
Broncholithiasis 18.79 10.44 14 631500 139 63867079
Extremity contracture 18.75 10.44 46 631468 1579 63865639
Persistent depressive disorder 18.73 10.44 35 631479 991 63866227
Abdominal distension 18.63 10.44 1133 630381 94861 63772357
Swollen joint count increased 18.62 10.44 29 631485 7660 63859558
Gastrointestinal motility disorder 18.62 10.44 100 631414 5079 63862139
Cholelithiasis 18.52 10.44 580 630934 44926 63822292
Low turnover osteopathy 18.49 10.44 50 631464 1823 63865395
Device related infection 18.47 10.44 201 631313 30425 63836793
Cerebral haematoma 18.37 10.44 127 631387 7058 63860160
Dyspnoea 18.36 10.44 7548 623966 711126 63156092
Hiatus hernia 18.36 10.44 286 631228 19671 63847547
Incorrect route of product administration 18.34 10.44 143 631371 23155 63844063
Eating disorder 18.29 10.44 248 631266 16557 63850661
Prostate cancer 18.28 10.44 116 631398 19679 63847539
Staphylococcal sepsis 18.12 10.44 65 631449 12834 63854384
Eye irritation 18.09 10.44 236 631278 15620 63851598
Pituitary tumour 18.08 10.44 36 631478 1070 63866148
Aggression 18.06 10.44 331 631183 45901 63821317
Systemic infection 18.03 10.44 87 631427 4234 63862984
Tooth fracture 17.96 10.44 162 631352 9765 63857453
Electrocardiogram ST segment elevation 17.94 10.44 27 631487 7232 63859986
Immunosuppressant drug level increased 17.94 10.44 27 631487 7232 63859986
Spinal osteoarthritis 17.88 10.44 217 631297 14124 63853094
Exophthalmos 17.83 10.44 44 631470 1516 63865702
Labile hypertension 17.80 10.44 24 631490 510 63866708
Pneumatosis intestinalis 17.78 10.44 15 631499 5214 63862004
Anosmia 17.76 10.44 88 631426 4329 63862889
Liver function test abnormal 17.75 10.44 731 630783 58670 63808548
Vaginal haemorrhage 17.71 10.44 277 631237 19067 63848151
Traumatic ulcer 17.69 10.44 9 631505 41 63867177
Depression 17.69 10.44 2052 629462 181239 63685979
Erythema dyschromicum perstans 17.62 10.44 10 631504 59 63867159
Thyroid cancer metastatic 17.62 10.44 13 631501 127 63867091
Breast cancer 17.51 10.44 391 631123 28757 63838461
Soft tissue disorder 17.49 10.44 71 631443 3205 63864013
Chest pain 17.49 10.44 2600 628914 233380 63633838
Hyperchromic anaemia 17.33 10.44 14 631500 158 63867060
Rheumatic fever 17.31 10.44 41 631473 9253 63857965
Product measured potency issue 17.31 10.44 15 631499 188 63867030
Thyroxine abnormal 17.25 10.44 6 631508 7 63867211
Application site erythema 17.17 10.44 91 631423 4598 63862620
Product solubility abnormal 17.07 10.44 30 631484 809 63866409
Acute graft versus host disease in intestine 17.00 10.44 7 631507 3602 63863616
Drug level increased 16.99 10.44 234 631280 33962 63833256
Growth hormone deficiency 16.93 10.44 19 631495 332 63866886
Transcription medication error 16.93 10.44 19 631495 332 63866886
Fungaemia 16.80 10.44 8 631506 3777 63863441
Hyperbilirubinaemia 16.76 10.44 130 631384 21075 63846143
Brain oedema 16.68 10.44 137 631377 21938 63845280
Amniotic fluid volume increased 16.66 10.44 13 631501 139 63867079
Bradycardia 16.63 10.44 1359 630155 116860 63750358
Ascites 16.55 10.44 471 631043 61530 63805688
Adenoiditis 16.53 10.44 8 631506 32 63867186
Thyrotoxic periodic paralysis 16.49 10.44 11 631503 90 63867128
Anaemia folate deficiency 16.49 10.44 16 631498 234 63866984
Blood glucose decreased 16.11 10.44 317 631197 22806 63844412
Device use error 16.06 10.44 24 631490 6447 63860771
Anaemia vitamin B12 deficiency 16.05 10.44 24 631490 563 63866655
Thyroglobulin decreased 15.86 10.44 5 631509 3 63867215
Presbyacusis 15.83 10.44 3 631511 2572 63864646
Follicular thyroid cancer 15.80 10.44 10 631504 74 63867144
Potassium wasting nephropathy 15.79 10.44 13 631501 151 63867067
Increased tendency to bruise 15.72 10.44 149 631365 9106 63858112
Rapid eye movement sleep behaviour disorder 15.67 10.44 18 631496 323 63866895
Liver disorder 15.62 10.44 400 631114 52951 63814267
Lung cyst 15.59 10.44 13 631501 154 63867064
Endocrine disorder 15.58 10.44 26 631488 672 63866546
Oculogyric crisis 15.51 10.44 3 631511 2535 63864683
Venoocclusive disease 15.40 10.44 10 631504 3975 63863243
Gingival pain 15.38 10.44 111 631403 6256 63860962
Hepatitis B 15.38 10.44 33 631481 7712 63859506
Diffuse large B-cell lymphoma 15.38 10.44 51 631463 10310 63856908
Meniere's disease 15.32 10.44 13 631501 158 63867060
Lactose intolerance 15.29 10.44 49 631465 1967 63865251
Tooth dislocation 15.27 10.44 7 631507 24 63867194
Seronegative arthritis 15.24 10.44 4 631510 2739 63864479
Rhinitis allergic 15.22 10.44 133 631381 7945 63859273
Frontotemporal dementia 15.16 10.44 22 631492 502 63866716
Cerebral microangiopathy 15.16 10.44 15 631499 225 63866993
Bone loss 15.11 10.44 51 631463 2104 63865114
Intercapillary glomerulosclerosis 15.10 10.44 9 631505 59 63867159
Vascular stent thrombosis 15.10 10.44 7 631507 3357 63863861
Dysstasia 15.09 10.44 315 631199 22900 63844318
Wrist fracture 15.04 10.44 157 631357 9844 63857374
Systemic candida 15.02 10.44 18 631496 5311 63861907
Listless 15.02 10.44 68 631446 3222 63863996
Neuromyopathy 15.02 10.44 38 631476 1330 63865888
Varicose vein 15.01 10.44 74 631440 3633 63863585
Ileus paralytic 14.99 10.44 38 631476 8377 63858841
Anaphylactic shock 14.90 10.44 208 631306 30120 63837098
Cortisol decreased 14.82 10.44 43 631471 1634 63865584
Change of bowel habit 14.78 10.44 55 631459 2383 63864835
Disability 14.78 10.44 65 631449 12107 63855111
Blood calcium increased 14.75 10.44 138 631376 8404 63858814
Neuroleptic malignant syndrome 14.69 10.44 165 631349 24831 63842387
Product administered to patient of inappropriate age 14.69 10.44 14 631500 4587 63862631
Bacterial sepsis 14.62 10.44 32 631482 7425 63859793
Pleural fibrosis 14.55 10.44 11 631503 4039 63863179
Full blood count decreased 14.55 10.44 306 631208 22276 63844942
Tonsillar cyst 14.54 10.44 4 631510 0 63867218
Mydriasis 14.51 10.44 89 631425 15223 63851995
Decreased bronchial secretion 14.51 10.44 9 631505 64 63867154
Parainfluenzae virus infection 14.49 10.44 15 631499 4728 63862490
Urine odour abnormal 14.47 10.44 93 631421 5043 63862175
Stenotrophomonas infection 14.47 10.44 6 631508 3074 63864144
Polyglandular autoimmune syndrome type II 14.46 10.44 7 631507 28 63867190
Pneumonia bacterial 14.46 10.44 87 631427 14948 63852270
Magnetic resonance imaging thoracic abnormal 14.45 10.44 6 631508 15 63867203
N-terminal prohormone brain natriuretic peptide abnormal 14.44 10.44 15 631499 239 63866979
Thyroiditis 14.43 10.44 72 631442 3552 63863666
Temperature regulation disorder 14.42 10.44 12 631502 4199 63863019
Oropharyngeal pain 14.40 10.44 1033 630481 87834 63779384
Back pain 14.37 10.44 2719 628795 247452 63619766
Breast discomfort 14.33 10.44 17 631497 316 63866902
Pneumonia viral 14.33 10.44 128 631386 7694 63859524
Abnormal weight gain 14.33 10.44 51 631463 2162 63865056
Vessel puncture site haemorrhage 14.31 10.44 13 631501 174 63867044
Metastases to pituitary gland 14.30 10.44 5 631509 6 63867212
Abdominal pain 14.28 10.44 3358 628156 309017 63558201
Product blister packaging issue 14.26 10.44 12 631502 144 63867074
Agranulocytosis 14.22 10.44 276 631238 37953 63829265
Pollakiuria 14.22 10.44 407 631107 31123 63836095
Pregnancy 14.21 10.44 133 631381 20732 63846486
Impaired driving ability 14.19 10.44 86 631428 4568 63862650
Contusion 14.15 10.44 1298 630216 112667 63754551
Delayed graft function 14.13 10.44 6 631508 3030 63864188
Palmar-plantar erythrodysaesthesia syndrome 14.12 10.44 376 631138 28443 63838775
Diffuse alveolar damage 14.11 10.44 7 631507 3228 63863990
COVID-19 pneumonia 14.09 10.44 99 631415 16405 63850813
Kounis syndrome 14.04 10.44 6 631508 3019 63864199
Intervertebral disc degeneration 14.03 10.44 193 631321 12927 63854291
Piloerection 13.98 10.44 19 631495 407 63866811
Sedation 13.98 10.44 517 630997 40945 63826273
Empty sella syndrome 13.97 10.44 9 631505 69 63867149
Pneumonia aspiration 13.92 10.44 458 631056 58813 63808405
Fibromyalgia 13.91 10.44 453 631061 35278 63831940
Viraemia 13.89 10.44 3 631511 2346 63864872
Scar 13.89 10.44 196 631318 13202 63854016
Anal prolapse 13.86 10.44 9 631505 70 63867148
Ventricular fibrillation 13.83 10.44 158 631356 23702 63843516
Intentional underdose 13.81 10.44 48 631466 2010 63865208
Total lung capacity abnormal 13.81 10.44 12 631502 151 63867067
Body height increased 13.78 10.44 10 631504 95 63867123
Pulmonary alveolar haemorrhage 13.73 10.44 49 631465 9689 63857529
Pulmonary valve incompetence 13.71 10.44 41 631473 1585 63865633
Cytomegalovirus colitis 13.69 10.44 11 631503 3917 63863301
Diabetic ketoacidosis 13.66 10.44 386 631128 29459 63837759
Upper limb fracture 13.66 10.44 213 631301 14653 63852565
Complications of transplanted kidney 13.64 10.44 20 631494 5415 63861803
Atrioventricular block first degree 13.63 10.44 163 631351 10571 63856647
Gastritis 13.55 10.44 528 630986 42090 63825128
Cryptococcosis 13.55 10.44 5 631509 2750 63864468
Drug interaction 13.51 10.44 3241 628273 358842 63508376
Abdominal pain lower 13.45 10.44 347 631167 26122 63841096
Paronychia 13.45 10.44 27 631487 6465 63860753
Pancreatic neuroendocrine tumour 13.41 10.44 20 631494 468 63866750
Blood calcitonin increased 13.41 10.44 7 631507 34 63867184
Disturbance in social behaviour 13.41 10.44 11 631503 3876 63863342
Acute lung injury 13.36 10.44 5 631509 2726 63864492
Panic disorder 13.36 10.44 58 631456 2699 63864519
Sexual dysfunction 13.33 10.44 27 631487 6444 63860774
Knee arthroplasty 13.33 10.44 185 631329 26814 63840404
Pulmonary arterial hypertension 13.31 10.44 334 631180 25033 63842185
Hormone level abnormal 13.27 10.44 42 631472 1675 63865543
Suspected suicide 13.26 10.44 42 631472 8612 63858606
Deep brain stimulation 13.24 10.44 8 631506 54 63867164
Acute hepatic failure 13.22 10.44 178 631336 25934 63841284
Hyperhidrosis 13.21 10.44 1407 630107 123513 63743705
Skin irritation 13.21 10.44 143 631371 9051 63858167
Blood loss anaemia 13.13 10.44 200 631314 13692 63853526
Pituitary cyst 13.12 10.44 5 631509 9 63867209
Sinus bradycardia 13.10 10.44 305 631209 22588 63844630
Supraventricular extrasystoles 13.09 10.44 101 631413 5814 63861404
Shock 13.06 10.44 280 631234 37960 63829258
Skin ulcer 13.06 10.44 329 631185 43645 63823573
Alcohol abuse 13.04 10.44 17 631497 4835 63862383
Pseudomonal sepsis 13.02 10.44 19 631495 5153 63862065
Gingival disorder 13.01 10.44 66 631448 3278 63863940
Metastases to neck 13.00 10.44 6 631508 21 63867197
Stress fracture 12.99 10.44 97 631417 5527 63861691
Spondylolisthesis 12.94 10.44 58 631456 2736 63864482
Dementia 12.93 10.44 280 631234 20486 63846732
Hyperthermia malignant 12.90 10.44 4 631510 2455 63864763
Feeling jittery 12.86 10.44 160 631354 10475 63856743
Madarosis 12.84 10.44 51 631463 2279 63864939
Immediate post-injection reaction 12.83 10.44 16 631498 314 63866904
Mineral deficiency 12.80 10.44 7 631507 38 63867180
Metastases to bone 12.77 10.44 133 631381 20302 63846916
Intermenstrual bleeding 12.76 10.44 90 631424 5035 63862183
Erectile dysfunction 12.71 10.44 72 631442 12555 63854663
Nasal congestion 12.70 10.44 710 630804 58948 63808270
Retching 12.68 10.44 215 631299 15041 63852177
Pulmonary oedema 12.66 10.44 635 630879 78039 63789179
Bacterial infection 12.66 10.44 170 631344 24780 63842438
Hypertensive crisis 12.66 10.44 250 631264 17998 63849220
Tracheal fistula 12.59 10.44 10 631504 110 63867108
Cervicogenic headache 12.59 10.44 6 631508 23 63867195
Fanconi syndrome acquired 12.59 10.44 4 631510 2417 63864801
Device use issue 12.52 10.44 43 631471 1790 63865428
Therapeutic product effect variable 12.51 10.44 40 631474 1604 63865614
Cataract 12.51 10.44 618 630896 50644 63816574
Tongue haematoma 12.47 10.44 13 631501 208 63867010
Therapeutic product effect increased 12.46 10.44 35 631479 1305 63865913
Meningitis cryptococcal 12.40 10.44 7 631507 3002 63864216
Migraine 12.39 10.44 741 630773 61936 63805282
Coronary arterial stent insertion 12.38 10.44 23 631491 5669 63861549
Osteoarthritis 12.37 10.44 748 630766 62588 63804630
Laryngeal injury 12.34 10.44 4 631510 3 63867215
Arterial occlusive disease 12.33 10.44 114 631400 6919 63860299
Immune effector cell-associated neurotoxicity syndrome 12.28 10.44 5 631509 2590 63864628
Abnormal uterine bleeding 12.26 10.44 26 631488 809 63866409
Renal tubular necrosis 12.20 10.44 148 631366 21962 63845256
Bladder disorder 12.19 10.44 123 631391 7644 63859574
Germ cell cancer 12.19 10.44 11 631503 146 63867072
Hypoglycaemic unconsciousness 12.16 10.44 31 631483 1090 63866128
Nephritic syndrome 12.15 10.44 14 631500 252 63866966
Bundle branch block left 12.15 10.44 151 631363 9883 63857335
Miosis 12.11 10.44 78 631436 13188 63854030
Pneumocystis jirovecii infection 12.10 10.44 4 631510 2357 63864861
Hair colour changes 12.09 10.44 70 631444 3657 63863561
Femur fracture 12.08 10.44 428 631086 33707 63833511
Drug specific antibody present 11.95 10.44 20 631494 5134 63862084
Brain natriuretic peptide abnormal 11.93 10.44 23 631491 667 63866551
Oesophageal achalasia 11.93 10.44 23 631491 667 63866551
Drug level decreased 11.90 10.44 65 631449 11438 63855780
Cytomegalovirus test positive 11.90 10.44 20 631494 5124 63862094
Hypoalbuminaemia 11.89 10.44 113 631401 17561 63849657
Faeces discoloured 11.84 10.44 333 631181 25396 63841822
Granuloma 11.82 10.44 30 631484 6611 63860607
Eye pain 11.81 10.44 399 631115 31226 63835992
Bronchitis 11.80 10.44 1227 630287 107516 63759702
International normalised ratio increased 11.77 10.44 914 630600 78253 63788965
Gastrointestinal tract irritation 11.73 10.44 20 631494 526 63866692
Urine sodium decreased 11.73 10.44 14 631500 262 63866956
Secondary immunodeficiency 11.72 10.44 6 631508 2718 63864500
Joint laxity 11.72 10.44 4 631510 2310 63864908
Oedema 11.70 10.44 1049 630465 90886 63776332
Lymph node calcification 11.66 10.44 15 631499 304 63866914
Gene mutation 11.64 10.44 3 631511 2079 63865139
Ocular discomfort 11.63 10.44 73 631441 3926 63863292
Senile osteoporosis 11.63 10.44 9 631505 95 63867123
Generalised tonic-clonic seizure 11.62 10.44 299 631215 39558 63827660
Hypotensive transfusion reaction 11.56 10.44 8 631506 70 63867148
Neutrophil count increased 11.55 10.44 175 631339 24999 63842219
Gastrointestinal tract mucosal pigmentation 11.51 10.44 27 631487 900 63866318
Upper respiratory tract inflammation 11.51 10.44 12 631502 3770 63863448
Pulmonary haemorrhage 11.51 10.44 78 631436 13031 63854187
Expired product administered 11.50 10.44 99 631415 5888 63861330
Cystic fibrosis 11.50 10.44 10 631504 3424 63863794
Pseudomembranous colitis 11.47 10.44 19 631495 4897 63862321
Superficial vein prominence 11.46 10.44 8 631506 71 63867147
Thyroid neoplasm 11.45 10.44 54 631460 2603 63864615
Ecchymosis 11.43 10.44 197 631317 13825 63853393
Metastases to lung 11.41 10.44 95 631419 15169 63852049
Congenital central nervous system anomaly 11.40 10.44 5 631509 15 63867203
Cystitis 11.37 10.44 519 630995 42156 63825062
Neoplasm recurrence 11.34 10.44 69 631445 3670 63863548
Dilatation atrial 11.33 10.44 65 631449 3385 63863833
Sensory level abnormal 11.31 10.44 10 631504 129 63867089
Astrocytoma 11.27 10.44 12 631502 197 63867021
Gastric pH increased 11.26 10.44 7 631507 50 63867168
Colorectal cancer 11.25 10.44 9 631505 3212 63864006
Rectocele 11.21 10.44 20 631494 546 63866672
Infection reactivation 11.20 10.44 3 631511 2027 63865191
Vaccination site pain 11.20 10.44 8 631506 74 63867144
Nerve compression 11.16 10.44 117 631397 7344 63859874
Polyhydramnios 11.15 10.44 36 631478 1451 63865767
Lichen nitidus 11.11 10.44 8 631506 75 63867143
Multiple allergies 11.10 10.44 96 631418 5718 63861500
Vulvovaginal discomfort 11.08 10.44 37 631477 1518 63865700
Chromaturia 11.08 10.44 295 631219 22316 63844902
Pharyngitis 11.06 10.44 126 631388 18913 63848305
Vulvovaginal mycotic infection 11.04 10.44 67 631447 3561 63863657
Eructation 10.99 10.44 138 631376 9053 63858165
Basedow's disease 10.99 10.44 13 631501 241 63866977
Rotator cuff repair 10.98 10.44 36 631478 1463 63865755
Blood test abnormal 10.97 10.44 183 631331 12760 63854458
Mean cell haemoglobin concentration increased 10.97 10.44 24 631490 763 63866455
Oropharyngeal swelling 10.97 10.44 31 631483 1160 63866058
Musculoskeletal discomfort 10.96 10.44 222 631292 16055 63851163
Anaemia postoperative 10.94 10.44 40 631474 1718 63865500
Cholecystitis chronic 10.92 10.44 139 631375 9148 63858070
Blood potassium decreased 10.91 10.44 492 631022 39907 63827311
Clear cell endometrial carcinoma 10.91 10.44 3 631511 0 63867218
Invasive papillary breast carcinoma 10.91 10.44 3 631511 0 63867218
Gallbladder mucocoele 10.91 10.44 3 631511 0 63867218
Blood proinsulin increased 10.91 10.44 3 631511 0 63867218
Primary hyperthyroidism 10.91 10.44 3 631511 0 63867218
Synovial cyst removal 10.91 10.44 3 631511 0 63867218
Hair growth rate abnormal 10.91 10.44 3 631511 0 63867218
Hypothyroidic goitre 10.91 10.44 3 631511 0 63867218
Tri-iodothyronine free 10.91 10.44 3 631511 0 63867218
Chronic fatigue syndrome 10.91 10.44 31 631483 1164 63866054
Product dispensing error 10.88 10.44 165 631349 11285 63855933
Tinnitus 10.88 10.44 423 631091 33710 63833508
Application site vesicles 10.83 10.44 33 631481 1289 63865929
Injection site hypertrophy 10.83 10.44 7 631507 54 63867164
Pituitary haemorrhage 10.80 10.44 14 631500 286 63866932
Blood sodium decreased 10.77 10.44 371 631143 29111 63838107
Renal cancer metastatic 10.75 10.44 22 631492 667 63866551
Painful respiration 10.75 10.44 59 631455 3022 63864196
Angle closure glaucoma 10.73 10.44 53 631461 2604 63864614
Parenteral nutrition 10.73 10.44 5 631509 18 63867200
Thyroglobulin increased 10.72 10.44 7 631507 55 63867163
Lens disorder 10.71 10.44 10 631504 139 63867079
Incorrect dose administered 10.66 10.44 711 630803 60054 63807164
Delirium 10.65 10.44 561 630953 68633 63798585
Neck injury 10.65 10.44 48 631466 2270 63864948
Application site swelling 10.62 10.44 21 631493 621 63866597
Multiple drug therapy 10.60 10.44 47 631467 2207 63865011
Emotional disorder 10.60 10.44 178 631336 12429 63854789
Recalled product 10.59 10.44 26 631488 893 63866325
Liver injury 10.56 10.44 218 631296 29714 63837504
Hepatic failure 10.55 10.44 439 631075 54955 63812263
Sinus disorder 10.53 10.44 228 631286 16680 63850538
Paternal exposure during pregnancy 10.52 10.44 5 631509 19 63867199
Transplant failure 10.50 10.44 13 631501 3781 63863437
Onychoclasis 10.49 10.44 79 631435 4513 63862705
Progressive multifocal leukoencephalopathy 10.46 10.44 121 631393 18111 63849107
Blood urea nitrogen/creatinine ratio increased 10.45 10.44 24 631490 789 63866429

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 30.05 18.73 36 2237 3794 78611
Small for dates baby 28.75 18.73 146 2127 2598 79807

Pharmacologic Action:

SourceCodeDescription
ATC H03AA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
THYROID PREPARATIONS
Thyroid hormones
FDA CS M0021504 Thyroxine
FDA EPC N0000175945 l-Thyroxine
CHEBI has role CHEBI:50671 antithyroid drugs
CHEBI has role CHEBI:60311 thyroid hormones
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:52290 mitogens
CHEBI has role CHEBI:53000 epitope role

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Goiter indication 3716002 DOID:12176
Hashimoto thyroiditis indication 21983002
Hypothyroidism indication 40930008 DOID:1459
Myxedema indication 43153006 DOID:11634
Hyperlipidemia indication 55822004 DOID:1168
Congenital hypothyroidism indication 190268003 DOID:0050328
Malignant tumor of thyroid gland indication 363478007 DOID:1781
Diagnostic Test for Thyroid Dysfunction indication
Myxedema coma off-label use 21263006
Myocardial infarction contraindication 22298006 DOID:5844
Thyrotoxic crisis contraindication 29028009 DOID:12837
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Osteoporosis contraindication 64859006 DOID:11476
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Angina pectoris contraindication 194828000
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000
Disorder of coronary artery contraindication 414024009




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Replacement therapy for diminished thyroid function Indication

🐶 Veterinary products

ProductApplicantIngredients
Thyro-Tabs Canine Lloyd Inc. 1
ThyroKare Neogen Corp. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.08 acidic
pKa2 6.63 acidic
pKa3 8.6 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.025MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.05MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.075MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.088MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.112MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.125MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.137MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.15MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.175MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.1MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.2MG **See current Annual Edition, 1.8 Description of Special Situations, Levothyroxine Sodium LEVOXYL KING PHARMS N021301 May 25, 2001 RX TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE
0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** LEVOXYL KING PHARMS N021301 May 25, 2001 DISCN TABLET ORAL 7101569 Oct. 2, 2023 METHOD OF USE OF ADMINISTERING LEVOTHYROXINE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thyroid hormone receptor alpha Nuclear hormone receptor AGONIST EC50 7.72 CHEMBL IUPHAR
Thyroid hormone receptor beta Nuclear hormone receptor AGONIST IC50 8.52 IUPHAR CHEMBL
Transthyretin Secreted IC50 4.98 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor Kd 6.40 CHEMBL
Retinoic acid receptor RXR-alpha Nuclear hormone receptor Kd 6.03 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 5.10 CHEMBL
THAP domain-containing protein 1 Unclassified WOMBAT-PK
Macrophage migration inhibitory factor Unclassified IC50 4.80 CHEMBL
Malate dehydrogenase, mitochondrial Enzyme IC50 4.36 CHEMBL
Thyroid hormone receptor beta Transcription factor IC50 7.46 CHEMBL

External reference:

IDSource
4017826 VUID
N0000179290 NUI
D01010 KEGG_DRUG
6106-07-6 SECONDARY_CAS_RN
4017826 VANDF
4022126 VANDF
CHEBI:18332 CHEBI
CHEMBL1624 ChEMBL_ID
CHEMBL2103741 ChEMBL_ID
CHEMBL559 ChEMBL_ID
CHEMBL42115 ChEMBL_ID
DB00451 DRUGBANK_ID
Q51BO43MG4 UNII
5819 PUBCHEM_CID
10582 RXNORM
1842 MMSL
4976 MMSL
d00278 MMSL
002132 NDDF
004881 NDDF
005896 NDDF
126202002 SNOMEDCT_US
38076006 SNOMEDCT_US
710809001 SNOMEDCT_US
73187006 SNOMEDCT_US
768532006 SNOMEDCT_US
783637002 SNOMEDCT_US
D013974 MESH_DESCRIPTOR_UI
C0040165 UMLSCUI
T44 PDB_CHEM_ID
453 INN_ID
55-03-8 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-3727 TABLET 137 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4341 TABLET 25 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-4552 TABLET 50 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-5182 TABLET 75 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6594 TABLET 88 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-6624 TABLET 100 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7068 TABLET 125 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7069 TABLET 150 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7070 TABLET 175 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7148 TABLET 200 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-7149 TABLET 300 ug ORAL NDA 25 sections
Synthroid HUMAN PRESCRIPTION DRUG LABEL 1 0074-9296 TABLET 112 ug ORAL NDA 25 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1800 TABLET 25 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1803 TABLET 50 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1805 TABLET 75 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1807 TABLET 88 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1809 TABLET 100 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1811 TABLET 112 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1813 TABLET 125 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1815 TABLET 150 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1817 TABLET 175 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1819 TABLET 200 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1821 TABLET 300 ug ORAL ANDA 26 sections
Levothyroxine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-1823 TABLET 137 ug ORAL ANDA 26 sections
UNITHROID HUMAN PRESCRIPTION DRUG LABEL 1 0527-1370 TABLET 0.03 mg ORAL NDA 24 sections
UNITHROID HUMAN PRESCRIPTION DRUG LABEL 1 0527-1371 TABLET 0.05 mg ORAL NDA 24 sections
UNITHROID HUMAN PRESCRIPTION DRUG LABEL 1 0527-1372 TABLET 0.08 mg ORAL NDA 24 sections
UNITHROID HUMAN PRESCRIPTION DRUG LABEL 1 0527-1373 TABLET 0.09 mg ORAL NDA 24 sections
UNITHROID HUMAN PRESCRIPTION DRUG LABEL 1 0527-1374 TABLET 0.10 mg ORAL NDA 24 sections
UNITHROID HUMAN PRESCRIPTION DRUG LABEL 1 0527-1375 TABLET 0.11 mg ORAL NDA 24 sections