thioproperazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2635 316-81-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thioproperazine
  • sulfenazin
  • thioperazine
  • tioproperazin
  • thioproperazine dimesylate
  • thioproperazine mesylate
  • thioproperazine mesyiate
  • thioproperazine mesilate
  • Molecular weight: 446.63
  • Formula: C22H30N4O2S2
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 47.10
  • ALOGS: -3.89
  • ROTB: 5

Drug dosage:

DoseUnitRoute
75 mg O
20 mg P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05AB08 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with piperazine structure
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.74 Basic
pKa2 4.74 Basic
pKa3 3.06 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(3) dopamine receptor GPCR Ki 8.92 PDSP
D(2) dopamine receptor GPCR Ki 9.35 PDSP

External reference:

IDSource
C0039936 UMLSCUI
D01447 KEGG_DRUG
71P630M192 UNII
2347-80-0 SECONDARY_CAS_RN
10498 RXNORM
003494 NDDF
CHEMBL609109 ChEMBL_ID
DB01622 DRUGBANK_ID
CHEBI:59120 CHEBI
911 INN_ID
CHEMBL1406487 ChEMBL_ID
CHEMBL1481539 ChEMBL_ID
9429 PUBCHEM_CID
C084825 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None