thiamylal Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2626 77-27-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamylal sodium
  • thiamylal
  • thioseconal
  • thioquinalbarbitone
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
  • Molecular weight: 254.35
  • Formula: C12H18N2O2S
  • CLOGP: 3.03
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.20
  • ALOGS: -3.70
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA PARKEDALE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atrioventricular block complete 20.93 0 3 11 1411 2356660

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000777 Anesthetics
CHEBI has role CHEBI:35717 sedative
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.32 acidic
pKa2 11.33 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018651 VUID
N0000179646 NUI
C0700559 UMLSCUI
D00713 KEGG_DRUG
01T23W89FR UNII
764664004 SNOMEDCT_US
764663005 SNOMEDCT_US
4019942 VANDF
10464 RXNORM
004579 NDDF
CHEBI:9536 CHEBI
CHEMBL440 ChEMBL_ID
337-47-3 SECONDARY_CAS_RN
DB01154 DRUGBANK_ID
3032285 PUBCHEM_CID
CHEMBL1201065 ChEMBL_ID
D013840 MESH_DESCRIPTOR_UI
7305 IUPHAR_LIGAND_ID

Pharmaceutical products:

None