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thiabendazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anthelminthics, tiabendazole derivatives	2621	148-79-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: thiabendazole thiabendazol thiabendole thiabenzole thibendole thibenzol thibenzole tiabendazol tiabendazole bovizole equizole mintesol mintezol minzolum omnizole	2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919) Molecular weight: 201.25 Formula: C10H7N3S CLOGP: 2.36 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 41.57 ALOGS: -3.16 ROTB: 1 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

thiabendazole
thiabendazol
thiabendole
thiabenzole
thibendole
thibenzol
thibenzole
tiabendazol
tiabendazole
bovizole
equizole
mintesol
mintezol
minzolum
omnizole

2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Molecular weight: 201.25
Formula: C10H7N3S
CLOGP: 2.36
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 41.57
ALOGS: -3.16
ROTB: 1

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
3	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.05 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	212.95 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
April 7, 1967	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D01AC06	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives
ATC	P02CA02	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTHELMINTICS ANTINEMATODAL AGENTS Benzimidazole derivatives
FDA EPC	N0000175481	Anthelmintic
MeSH PA	D000871	Anthelmintics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000977	Antiparasitic Agents
CHEBI has role	CHEBI:35444	antinematodal drugs
CHEBI has role	CHEBI:86328	anti-fungal agrichemical

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Infection by Strongyloides	indication	1214006	DOID:10955
Ascariasis	indication	2435008	DOID:456
Trichuriasis	indication	3752003
Cutaneous larva migrans	indication	19362000
Infection by larvae of Trichinella spiralis	indication	88264003
Enterobiasis	indication	266162007
Infection due to Toxocara	indication	406619001
Infection by Uncinaria	indication	414490001
Ancylostoma Duodenale Infection	indication
Necator Americanus Infection	indication
Trichostrongyliasis	off-label use	33710003	DOID:1254
Capillaria infection	off-label use	52979002	DOID:12474
Infection by Baylisascaris	off-label use	91156005
Infection by Dracunculus medinensis	off-label use	396334002	DOID:14418
Hepatic failure	contraindication	59927004
Kidney disease	contraindication	90708001	DOID:557
Liver function tests abnormal	contraindication	166603001

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Infections of Cooperia species	Indication
Cattle	Control of infections of gastrointestinal roundworms, Trichostrongylus species	Indication
Cattle	Control of infections of gastrointestinal roundworms, Haemonchus species	Indication
Cattle	Control of infections of gastrointestinal roundworms, Nematodirus species	Indication
Cattle	Control of infections of gastrointestinal roundworms, Ostertagia species	Indication
Cattle	Control of infections of gastrointestinal roundworms, Oesophagostomum radiatum	Indication
Horses	Control of large and small strongyles	Indication
Horses	Control of strongyloides	Indication
Horses	Control of pinworms of the genera Strongylus	Indication
Horses	Control of pinworms of the genera Cyathostomum Strongylus	Indication
Horses		Indication
Horses	Control of pinworms of the genera Cylicobrachytus	Indication
Horses	Control of pinworms of the genera Craterostomum	Indication
Horses	Control of pinworms of the genera Oesophagodontus	Indication
Horses	Control of pinworms of the genera Poteriostomum	Indication
Horses	Control of pinworms of the genera Oxyuris	Indication
Horses	Control of pinworms of the genera Strongyloides	Indication
Horses	Control of ascarids of the genus Parascaris	Indication
Goats	Infections of gastrointestinal roundworms, Trichostrongylus species	Indication
Goats	Infections of gastrointestinal roundworms, Haemonchus species	Indication
Goats	Infections of gastrointestinal roundworms, Ostertagia species	Indication
Goats	Infections of gastrointestinal roundworms, Cooperia species	Indication
Goats	Infections of gastrointestinal roundworms, Nematodirus species	Indication
Goats	Infections of gastrointestinal roundworms, Bunostomom species	Indication
Goats	Infections of gastrointestinal roundworms, Strongyloides species	Indication
Goats	Infections of gastrointestinal roundworms, Chabertia species	Indication
Goats	Infections of gastrointestinal roundworms, Oesophagostomum species	Indication
Pheasants	Treatment of gapeworms, Syngamus trachea	Indication
Sheep	Infections of gastrointestinal roundworms, Trichostrongylus species	Indication
Sheep	Infections of gastrointestinal roundworms, Haemonchus species	Indication
Sheep	Infections of gastrointestinal roundworms, Ostertagia species	Indication
Sheep	Infections of gastrointestinal roundworms, Cooperia species	Indication
Sheep	Infections of gastrointestinal roundworms, Nematodirus species	Indication
Sheep	Infections of gastrointestinal roundworms, Bunostomom species	Indication
Sheep	Infections of gastrointestinal roundworms, Strongyloides species	Indication
Sheep	Infections of gastrointestinal roundworms, Chabertia species	Indication
Sheep	Infections of gastrointestinal roundworms, Oesophagostomum species	Indication
Swine	Prevention of infections of large roundworms, (genus Ascaris)	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Thibenzole Sheep & Goat Wormer	Boehringer lngelheim Animal Health USA Inc.	1
Equizole Horse Wormer	Boehringer lngelheim Animal Health USA Inc.	1
Thibenzole 20% Swine Premix	Boehringer lngelheim Animal Health USA Inc.	1
Omnizole	Boehringer lngelheim Animal Health USA Inc.	1
TBZ Cattle Wormer (Drench)	Boehringer lngelheim Animal Health USA Inc.	1
TBZ 200 Medicated Feed Premix	Boehringer lngelheim Animal Health USA Inc.	1
Thibenzole (18 mg)	Boehringer lngelheim Animal Health USA Inc.	1
E-Z-EX Wormer Pellets	ADM Animal Nutrition	1
Equizole	Boehringer lngelheim Animal Health USA Inc.	1
Thibenzole Pig Wormer	Boehringer lngelheim Animal Health USA Inc.	1
Equizole A	Boehringer lngelheim Animal Health USA Inc.	2
Tresaderm Dermatologic Solution	Boehringer lngelheim Animal Health USA Inc.	3
E-Z-EX Wormer Mintrate Block	ADM Animal Nutrition	1
Thibenzole 300 Medicated	Boehringer lngelheim Animal Health USA Inc.	1
Equizole Horse Wormer Pellets	Boehringer lngelheim Animal Health USA Inc.	1
Equizole A Liquid	Boehringer lngelheim Animal Health USA Inc.	2
TBZ Wormer Paste 50%	Boehringer lngelheim Animal Health USA Inc.	1
TBZ Wormer Paste 43%	Boehringer lngelheim Animal Health USA Inc.	1
Equivet-14, Equizole-B	Farnam Companies Inc.	2
Equizole 50% Wormer Paste, Equizole 50% Wormer Paste For Horses	Boehringer lngelheim Animal Health USA Inc.	1
Thiabendazole, Dexamethasone, Neomycin Sulfate Solution	Dechra Veterinary Products LLC	3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.12	acidic
pKa2	4.62	Basic
pKa3	1.83	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Methionine aminopeptidase 2	Enzyme	P50579	MAP2_HUMAN		IC50	4.35	CHEMBL
Peptidyl-prolyl cis-trans isomerase FKBP1A	Enzyme	P62942	FKB1A_HUMAN		Kd	4.22	CHEMBL
Methionine aminopeptidase 1	Enzyme	P53582	MAP11_HUMAN		EC50	5.47	CHEMBL
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	6.10	DRUG MATRIX
Tubulin	Structural		C4PKY4_ECHGR C4PKZ2_ECHGR C4PKZ6_ECHGR	INHIBITOR			CHEMBL	CHEMBL
Tubulin	Structural		F1L005_ASCSU F1L4P8_ASCSU F1L5G6_ASCSU F1L7U3_ASCSU F1L7Y0_ASCSU F1L8A5_ASCSU F1LCS0_ASCSU	INHIBITOR			CHEMBL	CHEMBL
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Enzyme		SDHA_CAEEL				WOMBAT-PK
Methionine aminopeptidase	Enzyme		MAP1_ECOLI		IC50	6.33	CHEMBL
Reverse transcriptase/RNaseH	Enzyme		Q72547_9HIV1		IC50	4.84	CHEMBL

External reference:

ID	Source
4017955	VUID
N0000146305	NUI
D00372	KEGG_DRUG
4017955	VANDF
C0039832	UMLSCUI
CHEBI:45979	CHEBI
CHEMBL625	ChEMBL_ID
DB00730	DRUGBANK_ID
D013827	MESH_DESCRIPTOR_UI
5430	PUBCHEM_CID
1436	INN_ID
7304	IUPHAR_LIGAND_ID
N1Q45E87DT	UNII
10450	RXNORM
1245	MMSL
5565	MMSL
80871	MMSL
d00160	MMSL
002985	NDDF
36594001	SNOMEDCT_US
416624006	SNOMEDCT_US
TMG	PDB_CHEM_ID

Pharmaceutical products:

None