theophylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 2620 58-55-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aminophyllin
  • aminophylline
  • theophylline
  • 1,3-Dimethylxanthine
  • armophylline
  • cetraphylline
  • chronophyllin
  • duraphyllin
  • elixophyllin
  • elixophylline
  • etheophyl
  • lanophyllin
  • pseudotheophylline
  • theophyllin
  • throphylline
  • xanthium
  • theophylline anhydrous
  • aminophylline dihydrate
  • theophylline sodium glycinate
  • theophylline monohydrate
A plant genus of the family ASTERACEAE. The name "prickly burweed" is sometimes used but causes confusion with AMSINCKIA.
  • Molecular weight: 180.17
  • Formula: C7H8N4O2
  • CLOGP: -0.03
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 69.30
  • ALOGS: -0.80
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P
0.40 g R
0.60 g O
0.60 g P
0.60 g R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 8.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 18 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 48.12 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.51 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.86 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.61 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 7.20 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 1 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
April 19, 1940 FDA GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 662.75 13.78 496 26311 127065 63335150
Wheezing 528.16 13.78 386 26421 95209 63367006
Dyspnoea 231.56 13.78 706 26101 660607 62801608
Productive cough 206.19 13.78 188 26619 63020 63399195
Chronic obstructive pulmonary disease 176.77 13.78 172 26635 62514 63399701
Sputum discoloured 161.14 13.78 95 26712 16252 63445963
Rales 149.87 13.78 83 26724 12614 63449601
Cough 136.77 13.78 348 26459 292395 63169820
Forced expiratory volume decreased 123.55 13.78 54 26753 4914 63457301
Breath sounds abnormal 119.38 13.78 68 26739 10905 63451310
Chest discomfort 117.53 13.78 185 26622 109784 63352431
Sinus tachycardia 115.92 13.78 90 26717 24178 63438037
Bronchial neoplasm 113.98 13.78 29 26778 471 63461744
Nasal oedema 113.63 13.78 37 26770 1485 63460730
Pulmonary pain 110.36 13.78 45 26762 3445 63458770
Bronchial haemorrhage 109.12 13.78 29 26778 563 63461652
Nasal turbinate hypertrophy 106.36 13.78 30 26777 733 63461482
Nasal congestion 103.48 13.78 133 26674 65527 63396688
Endometrial ablation 95.14 13.78 29 26778 935 63461280
Obstructive airways disorder 95.04 13.78 75 26732 20624 63441591
Sleep disorder due to a general medical condition 95.04 13.78 61 26746 12127 63450088
Prolonged expiration 91.48 13.78 29 26778 1067 63461148
Bronchial disorder 90.82 13.78 30 26777 1260 63460955
Heart sounds 89.99 13.78 28 26779 968 63461247
Alopecia 89.67 13.78 17 26790 337519 63124696
Pneumonia 88.44 13.78 404 26403 456363 63005852
Rhonchi 84.15 13.78 34 26773 2542 63459673
Hypercapnia 79.55 13.78 41 26766 5390 63456825
Systemic lupus erythematosus 75.20 13.78 3 26804 208915 63253300
Respiratory tract infection 73.29 13.78 89 26718 41394 63420821
Bronchitis chronic 64.16 13.78 33 26774 4320 63457895
Status asthmaticus 63.55 13.78 21 26786 883 63461332
Lower respiratory tract infection 61.29 13.78 157 26650 132150 63330065
Occupational asthma 60.75 13.78 14 26793 146 63462069
Treatment failure 59.76 13.78 7 26800 199036 63263179
Dyspnoea exertional 59.65 13.78 98 26709 60204 63402011
Rheumatoid arthritis 59.02 13.78 17 26790 253802 63208413
Depressive symptom 57.31 13.78 30 26777 4072 63458143
Respiration abnormal 57.28 13.78 35 26772 6382 63455833
Joint swelling 56.84 13.78 34 26773 327632 63134583
Bronchial obstruction 56.59 13.78 22 26785 1485 63460730
Neurosensory hypoacusis 55.69 13.78 14 26793 216 63461999
Contraindicated product administered 53.59 13.78 13 26794 217635 63244580
Granuloma 52.91 13.78 32 26775 5729 63456486
Toxicity to various agents 52.45 13.78 225 26582 247025 63215190
Middle insomnia 52.08 13.78 43 26764 12600 63449615
Depressed mood 52.01 13.78 74 26733 40117 63422098
Hepatic enzyme increased 51.99 13.78 11 26796 202317 63259898
Rhinitis 51.78 13.78 41 26766 11325 63450890
Amyloid arthropathy 51.12 13.78 16 26791 564 63461651
Eosinophil count increased 51.03 13.78 40 26767 10888 63451327
Fatigue 49.83 13.78 200 26607 887828 62574387
Infusion related reaction 49.26 13.78 21 26786 245500 63216715
Oesophageal dilatation 47.98 13.78 14 26793 387 63461828
Bronchospasm 47.88 13.78 47 26760 17233 63444982
Drug intolerance 46.90 13.78 37 26770 308624 63153591
Rhinorrhoea 46.24 13.78 92 26715 65485 63396730
Chest pain 46.15 13.78 197 26610 215762 63246453
Affective disorder 46.04 13.78 30 26777 6116 63456099
Eosinophilic granulomatosis with polyangiitis 45.49 13.78 21 26786 2171 63460044
Drug interaction 45.15 13.78 204 26603 228927 63233288
Exercise tolerance decreased 44.06 13.78 28 26779 5469 63456746
Multiple drug therapy 43.47 13.78 24 26783 3622 63458593
Respiratory disorder 43.43 13.78 67 26740 39015 63423200
Swelling 43.12 13.78 32 26775 275346 63186869
Airway peak pressure increased 42.94 13.78 12 26795 283 63461932
Synovitis 42.56 13.78 13 26794 186905 63275310
Off label use 41.60 13.78 146 26661 674316 62787899
Respiratory rate increased 41.36 13.78 39 26768 13609 63448606
Appetite disorder 41.28 13.78 30 26777 7291 63454924
Respiratory acidosis 41.28 13.78 29 26778 6686 63455529
Drug ineffective 41.16 13.78 266 26541 1044499 62417716
Congestive cardiomyopathy 41.06 13.78 28 26779 6154 63456061
Product use issue 40.93 13.78 21 26786 220499 63241716
Therapeutic product effect decreased 39.59 13.78 16 26791 193171 63269044
PCO2 increased 39.26 13.78 16 26791 1223 63460992
Oligoarthritis 39.08 13.78 13 26794 558 63461657
Rash 39.03 13.78 115 26692 560756 62901459
Lung hyperinflation 38.57 13.78 16 26791 1279 63460936
Female sterilisation 38.14 13.78 13 26794 602 63461613
Arteriosclerosis coronary artery 37.70 13.78 30 26777 8343 63453872
Vital capacity decreased 37.26 13.78 17 26790 1711 63460504
Lipohypertrophy 37.14 13.78 13 26794 652 63461563
Increased viscosity of bronchial secretion 36.78 13.78 11 26796 332 63461883
Sinus pain 36.73 13.78 21 26786 3389 63458826
Decreased bronchial secretion 36.73 13.78 8 26799 63 63462152
Discomfort 35.72 13.78 13 26794 167361 63294854
Acute respiratory failure 35.38 13.78 57 26750 34428 63427787
Emphysema 34.58 13.78 32 26775 10906 63451309
Respiratory tract inflammation 34.47 13.78 12 26795 592 63461623
Blood pressure inadequately controlled 34.14 13.78 23 26784 4955 63457260
PO2 decreased 33.05 13.78 15 26792 1491 63460724
Adrenal suppression 32.97 13.78 13 26794 911 63461304
Eosinophilia 32.58 13.78 44 26763 22712 63439503
Painful respiration 32.36 13.78 18 26789 2756 63459459
Abdominal discomfort 31.94 13.78 54 26753 320831 63141384
Respiratory failure 31.80 13.78 105 26702 101753 63360462
Dyspnoea at rest 30.77 13.78 20 26787 4059 63458156
Asthmatic crisis 30.40 13.78 15 26792 1798 63460417
Eye paraesthesia 30.26 13.78 8 26799 152 63462063
Viral infection 30.05 13.78 54 26753 35609 63426606
Diarrhoea 29.68 13.78 179 26628 715187 62747028
Influenza 29.52 13.78 107 26700 108615 63353600
Full blood count abnormal 29.29 13.78 50 26757 31667 63430548
Blood bicarbonate decreased 28.73 13.78 17 26790 2924 63459291
Stress cardiomyopathy 28.63 13.78 27 26780 9423 63452792
Blood pH decreased 28.05 13.78 16 26791 2571 63459644
Psoriatic arthropathy 28.00 13.78 3 26804 91517 63370698
Glossitis 27.99 13.78 17 26790 3065 63459150
Ligament pain 27.78 13.78 8 26799 211 63462004
Arthropathy 27.77 13.78 35 26772 234757 63227458
Tachycardia 27.73 13.78 111 26696 118045 63344170
Impaired healing 27.53 13.78 5 26802 102537 63359678
Heart rate increased 27.52 13.78 95 26712 94143 63368072
Breast neoplasm 27.49 13.78 13 26794 1419 63460796
Febrile neutropenia 27.38 13.78 8 26799 118441 63343774
Intentional product use issue 27.17 13.78 10 26797 127882 63334333
Left ventricular failure 26.95 13.78 21 26786 5666 63456549
Musculoskeletal stiffness 26.93 13.78 23 26784 184595 63277620
Neutropenia 26.53 13.78 21 26786 174984 63287231
Oxygen saturation decreased 26.48 13.78 90 26717 88495 63373720
Pleural rub 26.17 13.78 6 26801 61 63462154
Stomatitis 26.04 13.78 13 26794 138712 63323503
Lung opacity 25.05 13.78 16 26791 3152 63459063
Depressed level of consciousness 25.01 13.78 70 26737 62008 63400207
Myopathy 24.79 13.78 27 26780 11164 63451051
Paranasal sinus hypersecretion 24.76 13.78 17 26790 3778 63458437
Diabetes mellitus 24.55 13.78 65 26742 55745 63406470
Flail chest 24.41 13.78 6 26801 84 63462131
Diabetes mellitus inadequate control 24.37 13.78 31 26776 15095 63447120
Stress urinary incontinence 24.02 13.78 14 26793 2341 63459874
Lung perforation 23.90 13.78 6 26801 92 63462123
Drug level increased 23.90 13.78 38 26769 22698 63439517
Drug level above therapeutic 23.33 13.78 18 26789 4787 63457428
Respiratory tract congestion 23.31 13.78 33 26774 17799 63444416
Ankle fracture 23.27 13.78 33 26774 17822 63444393
Kyphosis 23.04 13.78 14 26793 2526 63459689
Infective exacerbation of chronic obstructive airways disease 22.88 13.78 11 26796 1246 63460969
Completed suicide 22.68 13.78 17 26790 145656 63316559
Crepitations 22.52 13.78 22 26785 8018 63454197
Spleen congestion 22.45 13.78 6 26801 119 63462096
Pertussis 22.16 13.78 9 26798 682 63461533
Increased bronchial secretion 22.09 13.78 12 26795 1754 63460461
Respiratory symptom 21.85 13.78 15 26792 3332 63458883
Urogenital haemorrhage 21.76 13.78 7 26800 270 63461945
Allergic cough 21.63 13.78 9 26798 725 63461490
Breast conserving surgery 21.61 13.78 10 26797 1039 63461176
Sputum abnormal 21.61 13.78 9 26798 727 63461488
Presbyacusis 21.49 13.78 14 26793 2851 63459364
Pain 21.37 13.78 205 26602 740423 62721792
Hypoventilation 21.33 13.78 17 26790 4737 63457478
Obesity 21.07 13.78 42 26765 29910 63432305
Seizure 21.00 13.78 111 26696 132523 63329692
Pulmonary congestion 20.96 13.78 31 26776 17387 63444828
Overdose 20.82 13.78 100 26707 114978 63347237
Macrocytosis 20.77 13.78 13 26794 2472 63459743
Oesophagogastroduodenoscopy 20.59 13.78 6 26801 165 63462050
Thoracic operation 20.56 13.78 6 26801 166 63462049
Tremor 20.48 13.78 110 26697 132129 63330086
Antasthmatic drug level above therapeutic 20.31 13.78 3 26804 0 63462215
Vomiting 20.22 13.78 340 26467 559277 62902938
Malaise 20.21 13.78 266 26541 415688 63046527
Cyanosis 20.18 13.78 30 26777 16905 63445310
Rhabdomyolysis 20.16 13.78 52 26755 43899 63418316
Latent tuberculosis 20.11 13.78 13 26794 2614 63459601
Blood immunoglobulin E increased 19.97 13.78 15 26792 3834 63458381
Haemoptysis 19.88 13.78 40 26767 28686 63433529
Angina pectoris 19.77 13.78 41 26766 30037 63432178
Blood lactic acid increased 19.12 13.78 19 26788 7067 63455148
Glaucoma 19.05 13.78 31 26776 18874 63443341
Peripheral swelling 18.82 13.78 54 26753 265888 63196327
Disease progression 18.26 13.78 15 26792 122743 63339472
Oropharyngeal candidiasis 18.06 13.78 9 26798 1102 63461113
Muscle injury 17.95 13.78 3 26804 65342 63396873
Injection site hypoaesthesia 17.76 13.78 7 26800 490 63461725
Staphylococcus test positive 17.63 13.78 14 26793 3882 63458333
Hyperventilation 17.62 13.78 17 26790 6099 63456116
Stress 17.30 13.78 65 26742 67102 63395113
Gastrointestinal disorder 17.20 13.78 18 26789 131221 63330994
Bronchitis 16.75 13.78 100 26707 124835 63337380
Hypokalaemia 16.51 13.78 87 26720 103717 63358498
Oedema 16.35 13.78 83 26724 97539 63364676
Rib fracture 16.27 13.78 32 26775 22565 63439650
Food allergy 16.25 13.78 22 26785 11379 63450836
White blood cell count decreased 16.16 13.78 21 26786 139083 63323132
Upper respiratory tract infection 16.08 13.78 73 26734 81974 63380241
Blood cholesterol increased 15.93 13.78 10 26797 94022 63368193
Fibromyalgia 15.92 13.78 7 26800 80413 63381802
Arthralgia 15.85 13.78 159 26648 569551 62892664
Obstruction 15.81 13.78 12 26795 3115 63459100
Anaemia 15.77 13.78 67 26740 293363 63168852
Flank pain 15.32 13.78 26 26781 16384 63445831
Ventricular tachycardia 15.25 13.78 29 26778 19950 63442265
Supraventricular tachycardia 15.20 13.78 24 26783 14247 63447968
Generalised tonic-clonic seizure 15.07 13.78 36 26771 28980 63433235
Dysphonia 14.77 13.78 49 26758 47565 63414650
Mental disability 14.71 13.78 4 26803 85 63462130
Blister 14.67 13.78 20 26787 129794 63332421
Cushingoid 14.64 13.78 18 26789 8467 63453748
Anaphylactic reaction 14.63 13.78 61 26746 66039 63396176
Vaccination site haemorrhage 14.48 13.78 3 26804 18 63462197
Loss of personal independence in daily activities 14.43 13.78 80 26727 97210 63365005
Seasonal allergy 14.29 13.78 29 26778 20921 63441294
Status epilepticus 14.04 13.78 24 26783 15209 63447006
Atopy 13.97 13.78 5 26802 268 63461947
Aortic valve calcification 13.86 13.78 6 26801 533 63461682
Medication error 13.80 13.78 51 26756 52233 63409982

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 628.31 13.96 343 17448 42313 34896827
Wheezing 325.34 13.96 223 17568 41179 34897961
Chronic obstructive pulmonary disease 244.58 13.96 201 17590 48717 34890423
Obstructive airways disorder 204.09 13.96 116 17675 15378 34923762
Right atrial hypertrophy 171.63 13.96 46 17745 759 34938381
Forced expiratory volume decreased 154.47 13.96 59 17732 3144 34935996
Full blood count abnormal 152.23 13.96 103 17688 18565 34920575
Bronchial secretion retention 150.48 13.96 48 17743 1488 34937652
Bronchial wall thickening 147.53 13.96 46 17745 1322 34937818
Dyspnoea 146.24 13.96 471 17320 376311 34562829
Right ventricular hypertrophy 142.34 13.96 46 17745 1488 34937652
Productive cough 137.93 13.96 130 17661 37683 34901457
Therapeutic product effect incomplete 130.15 13.96 144 17647 50397 34888743
Pulmonary function test abnormal 125.58 13.96 48 17743 2562 34936578
Aortic valve stenosis 123.95 13.96 48 17743 2655 34936485
Obstruction 123.67 13.96 48 17743 2671 34936469
Chest X-ray abnormal 113.88 13.96 52 17739 4346 34934794
Sleep disorder due to a general medical condition 111.36 13.96 54 17737 5167 34933973
Loss of personal independence in daily activities 105.83 13.96 106 17685 33073 34906067
Diastolic dysfunction 96.72 13.96 52 17739 6175 34932965
Gastrooesophageal reflux disease 92.36 13.96 105 17686 37819 34901321
Intervertebral disc degeneration 89.75 13.96 50 17741 6367 34932773
Rhinitis perennial 80.77 13.96 21 17770 306 34938834
Cough 77.19 13.96 208 17583 149932 34789208
Vital capacity decreased 77.00 13.96 21 17770 371 34938769
Bronchiectasis 74.95 13.96 52 17739 9749 34929391
Osteoporosis 71.57 13.96 56 17735 12612 34926528
Sputum discoloured 63.40 13.96 43 17748 7769 34931371
Benign prostatic hyperplasia 60.93 13.96 54 17737 14441 34924699
Adjustment disorder 57.46 13.96 22 17769 1179 34937961
Radiation inflammation 55.89 13.96 20 17771 885 34938255
Foetal malformation 54.95 13.96 13 17778 125 34939015
Gout 53.23 13.96 57 17734 19196 34919944
Emphysema 51.42 13.96 41 17750 9484 34929656
Sleep apnoea syndrome 50.69 13.96 57 17734 20264 34918876
Respiratory failure 50.37 13.96 145 17646 108427 34830713
Pulmonary pain 50.01 13.96 20 17771 1204 34937936
Lung diffusion disorder 49.01 13.96 12 17779 135 34939005
Eosinophil count increased 48.65 13.96 38 17753 8534 34930606
Forced vital capacity decreased 47.36 13.96 17 17774 759 34938381
Atrial fibrillation 47.01 13.96 153 17638 122240 34816900
Chest discomfort 46.13 13.96 92 17699 54438 34884702
Mental disability 45.86 13.96 10 17781 64 34939076
Ocular discomfort 45.29 13.96 22 17769 2112 34937028
Hypoacusis 44.60 13.96 48 17743 16253 34922887
Pulmonary function test decreased 44.26 13.96 29 17762 4946 34934194
Off label use 41.98 13.96 95 17696 419429 34519711
Hypercapnia 40.80 13.96 26 17765 4229 34934911
Fungal disease carrier 40.65 13.96 12 17779 285 34938855
Inguinal hernia repair 39.80 13.96 12 17779 307 34938833
Anxiety 39.71 13.96 126 17665 99302 34839838
Seasonal allergy 38.77 13.96 30 17761 6645 34932495
Oropharyngeal candidiasis 35.49 13.96 14 17777 813 34938327
Bronchial obstruction 35.32 13.96 17 17774 1599 34937541
Total lung capacity abnormal 33.49 13.96 9 17782 150 34938990
Trisomy 18 32.90 13.96 13 17778 758 34938382
Supraventricular tachycardia 32.65 13.96 34 17757 11083 34928057
Diarrhoea 32.30 13.96 97 17694 389815 34549325
Eosinophilic granulomatosis with polyangiitis 31.99 13.96 17 17774 1970 34937170
Dyspnoea exertional 31.88 13.96 69 17722 43210 34895930
Neutropenia 30.86 13.96 21 17770 156757 34782383
Eosinophilic bronchitis 30.44 13.96 9 17782 215 34938925
Dermatitis allergic 29.81 13.96 26 17765 6804 34932336
Febrile neutropenia 28.75 13.96 17 17774 136832 34802308
Hypercholesterolaemia 27.92 13.96 28 17763 8734 34930406
Obesity 26.92 13.96 33 17758 12845 34926295
Tachycardia foetal 26.66 13.96 9 17782 334 34938806
Wolff-Parkinson-White syndrome 26.05 13.96 8 17783 218 34938922
Blood immunoglobulin E increased 25.52 13.96 16 17775 2530 34936610
Foetal distress syndrome 25.34 13.96 12 17779 1088 34938052
Pain 25.05 13.96 41 17750 204634 34734506
Lung hyperinflation 24.43 13.96 11 17780 889 34938251
Pancytopenia 24.33 13.96 9 17782 95148 34843992
Sputum increased 24.02 13.96 15 17776 2355 34936785
Lower respiratory tract infection 23.94 13.96 51 17740 31586 34907554
Glaucoma 23.72 13.96 23 17768 6889 34932251
Tachycardia 23.21 13.96 95 17696 84677 34854463
Pneumonia 22.38 13.96 282 17509 362345 34576795
Eye pruritus 22.16 13.96 23 17768 7466 34931674
Lung neoplasm malignant 21.98 13.96 35 17756 17360 34921780
Pulmonary artery dilatation 21.61 13.96 7 17784 228 34938912
Hypoxia 21.22 13.96 69 17722 55026 34884114
Supraventricular extrasystoles 20.88 13.96 16 17775 3492 34935648
Conduction disorder 20.50 13.96 13 17778 2097 34937043
Product use in unapproved indication 20.24 13.96 18 17773 117481 34821659
Reversible airways obstruction 20.01 13.96 8 17783 481 34938659
Neuropathy peripheral 19.46 13.96 9 17782 83254 34855886
Schizophrenia 19.41 13.96 23 17768 8643 34930497
Status asthmaticus 19.18 13.96 7 17784 328 34938812
Arthralgia 19.04 13.96 36 17755 170005 34769135
Arrhythmia 18.72 13.96 50 17741 35758 34903382
Tachyarrhythmia 18.35 13.96 15 17776 3593 34935547
Drug level increased 18.33 13.96 37 17754 22059 34917081
Stenotrophomonas infection 18.04 13.96 12 17779 2098 34937042
Acute kidney injury 17.99 13.96 87 17704 304901 34634239
Dizziness exertional 17.92 13.96 6 17785 217 34938923
Ventricular extrasystoles 17.77 13.96 26 17765 11982 34927158
Thrombocytopenia 17.56 13.96 33 17758 156214 34782926
Perfume sensitivity 17.34 13.96 5 17786 109 34939031
Sudden infant death syndrome 17.30 13.96 6 17785 242 34938898
Cardiac failure congestive 17.29 13.96 86 17705 83184 34855956
Lung neoplasm 16.95 13.96 16 17775 4635 34934505
Respiratory disorder 16.87 13.96 33 17758 19231 34919909
Lung opacity 16.83 13.96 12 17779 2347 34936793
Post streptococcal glomerulonephritis 16.81 13.96 5 17786 122 34939018
Carbon dioxide increased 16.71 13.96 9 17782 1072 34938068
Breath sounds abnormal 16.64 13.96 19 17772 6862 34932278
Eosinophilic pneumonia chronic 16.28 13.96 6 17785 289 34938851
Somnambulism 16.10 13.96 13 17778 3059 34936081
Tonic convulsion 15.82 13.96 9 17782 1192 34937948
Haemophilus infection 15.68 13.96 9 17782 1212 34937928
Death 15.51 13.96 129 17662 397920 34541220
Knee arthroplasty 15.43 13.96 19 17772 7425 34931715
Cushingoid 15.33 13.96 12 17779 2702 34936438
Back pain 15.25 13.96 24 17767 121765 34817375
Axial spondyloarthritis 15.25 13.96 6 17785 346 34938794
Unmasking of previously unidentified disease 15.23 13.96 8 17783 906 34938234
Lipid metabolism disorder 15.18 13.96 6 17785 350 34938790
Discomfort 14.87 13.96 31 17760 18907 34920233
Gastrointestinal necrosis 14.85 13.96 13 17778 3416 34935724
Nikolsky's sign 14.55 13.96 5 17786 196 34938944
Loss of proprioception 14.51 13.96 6 17785 394 34938746
Vitamin D increased 14.49 13.96 4 17787 74 34939066
Depressed mood 14.45 13.96 31 17760 19286 34919854
Epidural lipomatosis 14.16 13.96 8 17783 1046 34938094

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 1002.69 12.47 697 39152 134398 79570141
Wheezing 716.56 12.47 537 39312 116127 79588412
Chronic obstructive pulmonary disease 356.22 12.47 314 39535 85105 79619434
Productive cough 285.83 12.47 282 39567 88049 79616490
Dyspnoea 283.91 12.47 1004 38845 856021 78848518
Forced expiratory volume decreased 241.38 12.47 104 39745 7710 79696829
Obstructive airways disorder 236.56 12.47 164 39685 31295 79673244
Sleep disorder due to a general medical condition 181.92 12.47 104 39745 14173 79690366
Cough 169.43 12.47 483 39366 366306 79338233
Sputum discoloured 164.97 12.47 114 39735 21629 79682910
Right atrial hypertrophy 164.88 12.47 44 39805 727 79703812
Pulmonary pain 152.97 12.47 64 39785 4409 79700130
Right ventricular hypertrophy 132.18 12.47 44 39805 1593 79702946
Obstruction 128.23 12.47 57 39792 4553 79699986
Bronchial wall thickening 125.85 12.47 48 39801 2593 79701946
Full blood count abnormal 124.86 12.47 126 39723 40348 79664191
Rales 120.08 12.47 91 39758 19910 79684629
Chest discomfort 113.88 12.47 228 39621 137816 79566723
Breath sounds abnormal 112.39 12.47 80 39769 15904 79688635
Bronchial neoplasm 108.68 12.47 29 39820 479 79704060
Sinus tachycardia 106.78 12.47 111 39738 36797 79667742
Pulmonary function test abnormal 104.97 12.47 48 39801 4096 79700443
Hypercapnia 103.00 12.47 61 39788 8874 79695665
Aortic valve stenosis 102.58 12.47 51 39798 5243 79699296
Bronchial secretion retention 102.28 12.47 47 39802 4057 79700482
Nasal congestion 100.30 12.47 155 39694 76397 79628142
Nasal turbinate hypertrophy 98.87 12.47 29 39820 686 79703853
Nasal oedema 95.53 12.47 35 39814 1689 79702850
Endometrial ablation 92.51 12.47 29 39820 864 79703675
Pneumonia 91.51 12.47 603 39246 659643 79044896
Eosinophil count increased 85.80 12.47 70 39779 17035 79687504
Loss of personal independence in daily activities 85.25 12.47 170 39679 102410 79602129
Bronchial obstruction 82.73 12.47 36 39813 2732 79701807
Heart sounds 82.14 12.47 27 39822 939 79703600
Rhonchi 81.53 12.47 40 39809 3996 79700543
Bronchial haemorrhage 81.39 12.47 29 39820 1291 79703248
Chest X-ray abnormal 81.02 12.47 50 39799 7833 79696706
Emphysema 76.12 12.47 64 39785 16236 79688303
Therapeutic product effect incomplete 75.63 12.47 197 39652 141448 79563091
Prolonged expiration 74.89 12.47 27 39822 1244 79703295
Rhinitis perennial 74.74 12.47 20 39829 334 79704205
Lower respiratory tract infection 74.48 12.47 185 39664 129035 79575504
Alopecia 74.33 12.47 13 39836 231342 79473197
Bronchial disorder 69.95 12.47 31 39818 2458 79702081
Mental disability 69.93 12.47 14 39835 56 79704483
Status asthmaticus 68.64 12.47 24 39825 1010 79703529
Diastolic dysfunction 66.69 12.47 50 39799 10761 79693778
Off label use 66.54 12.47 232 39617 906983 78797556
Benign prostatic hyperplasia 65.68 12.47 51 39798 11561 79692978
Rhinitis 62.76 12.47 55 39794 14752 79689787
Dyspnoea exertional 62.61 12.47 136 39713 86937 79617602
Neutropenia 60.90 12.47 34 39815 287676 79416863
Depressed mood 60.48 12.47 96 39753 48384 79656155
Sleep apnoea syndrome 59.59 12.47 82 39767 36396 79668143
Respiratory failure 59.28 12.47 212 39637 180699 79523840
Respiratory tract infection 58.80 12.47 95 39754 48594 79655945
Lung hyperinflation 58.25 12.47 25 39824 1834 79702705
Febrile neutropenia 57.07 12.47 22 39827 230977 79473562
Atrial fibrillation 56.61 12.47 222 39627 197664 79506875
Radiation inflammation 56.24 12.47 20 39829 885 79703654
Diarrhoea 55.03 12.47 240 39609 880249 78824290
Respiratory disorder 54.82 12.47 88 39761 44768 79659771
Respiration abnormal 54.79 12.47 39 39810 7749 79696790
Rheumatoid arthritis 54.67 12.47 18 39831 208452 79496087
Infusion related reaction 53.54 12.47 24 39825 230213 79474326
Eosinophilic granulomatosis with polyangiitis 52.98 12.47 29 39820 3631 79700908
Hepatic enzyme increased 51.08 12.47 14 39835 182596 79521943
Gout 50.35 12.47 62 39787 24687 79679852
Bronchiectasis 50.32 12.47 59 39790 22327 79682212
Intervertebral disc degeneration 50.25 12.47 50 39799 15735 79688804
Osteoporosis 50.22 12.47 94 39755 54018 79650521
Oropharyngeal candidiasis 49.75 12.47 22 39827 1735 79702804
Joint swelling 49.33 12.47 43 39806 288603 79415936
Seasonal allergy 48.63 12.47 50 39799 16356 79688183
Neurosensory hypoacusis 48.59 12.47 13 39836 217 79704322
Systemic lupus erythematosus 48.57 12.47 3 39846 121146 79583393
Bronchospasm 48.53 12.47 61 39788 24798 79679741
Amyloid arthropathy 48.47 12.47 16 39833 564 79703975
Lung diffusion disorder 45.80 12.47 12 39837 184 79704355
Fatigue 44.79 12.47 277 39572 929450 78775089
Middle insomnia 44.10 12.47 47 39802 16022 79688517
Airway peak pressure increased 43.34 12.47 13 39836 333 79704206
Obesity 43.04 12.47 69 39780 35056 79669483
Rhinorrhoea 42.85 12.47 108 39741 75966 79628573
Tachycardia 41.90 12.47 188 39661 177580 79526959
Supraventricular tachycardia 41.21 12.47 52 39797 21218 79683321
Gastrooesophageal reflux disease 41.06 12.47 130 39719 104116 79600423
Treatment failure 40.85 12.47 17 39832 170469 79534070
Respiratory rate increased 40.57 12.47 52 39797 21548 79682991
Forced vital capacity decreased 40.44 12.47 19 39830 1724 79702815
Depressive symptom 40.27 12.47 30 39819 6393 79698146
Toxicity to various agents 40.15 12.47 353 39496 421187 79283352
Intentional product use issue 40.10 12.47 13 39836 152099 79552440
Product use issue 39.96 12.47 28 39821 209794 79494745
Pulmonary function test decreased 39.87 12.47 32 39817 7605 79696934
Inguinal hernia repair 39.61 12.47 12 39837 318 79704221
Synovitis 39.53 12.47 13 39836 150721 79553818
Hypoacusis 39.40 12.47 61 39788 30089 79674450
Fungal disease carrier 38.72 12.47 12 39837 344 79704195
Pericarditis 37.85 12.47 4 39845 104232 79600307
Granuloma 37.55 12.47 32 39817 8265 79696274
Affective disorder 37.48 12.47 32 39817 8287 79696252
Glossodynia 37.44 12.47 4 39845 103333 79601206
Vital capacity decreased 36.69 12.47 18 39831 1798 79702741
Therapeutic product effect decreased 36.67 12.47 18 39831 163845 79540694
Respiratory acidosis 36.62 12.47 36 39813 11164 79693375
PCO2 increased 36.46 12.47 18 39831 1822 79702717
Drug level increased 35.70 12.47 68 39781 39583 79664956
Decreased bronchial secretion 35.16 12.47 8 39841 65 79704474
Congestive cardiomyopathy 35.09 12.47 36 39813 11744 79692795
Multiple drug therapy 34.79 12.47 23 39826 4055 79700484
Oligoarthritis 33.93 12.47 13 39836 711 79703828
Hypercholesterolaemia 33.41 12.47 49 39800 23046 79681493
Appetite disorder 33.30 12.47 29 39820 7710 79696829
Exercise tolerance decreased 33.14 12.47 31 39818 9040 79695499
Increased viscosity of bronchial secretion 33.09 12.47 12 39837 562 79703977
Stomatitis 33.02 12.47 16 39833 146741 79557798
Adjustment disorder 32.77 12.47 22 39827 3978 79700561
Sinus pain 31.67 12.47 21 39828 3721 79700818
Blood immunoglobulin E increased 31.46 12.47 25 39824 5857 79698682
PO2 decreased 30.97 12.47 19 39830 2944 79701595
Hypoventilation 30.95 12.47 27 39822 7197 79697342
Blood pressure inadequately controlled 30.39 12.47 25 39824 6152 79698387
Anaemia 30.38 12.47 117 39732 444898 79259641
Impaired healing 30.25 12.47 4 39845 87651 79616888
Blood pH decreased 29.53 12.47 22 39827 4689 79699850
Asthmatic crisis 29.33 12.47 16 39833 1990 79702549
Wound 28.79 12.47 11 39838 116168 79588371
Drug interaction 28.52 12.47 325 39524 414858 79289681
Respiratory tract inflammation 28.28 12.47 12 39837 856 79703683
Lipohypertrophy 28.07 12.47 12 39837 872 79703667
Influenza 27.53 12.47 133 39716 129473 79575066
Thrombocytopenia 27.52 12.47 57 39792 265202 79439337
Arrhythmia 27.48 12.47 80 39769 61192 79643347
Breast neoplasm 27.46 12.47 12 39837 920 79703619
Rash 27.40 12.47 173 39676 578185 79126354
Eosinophilic bronchitis 27.30 12.47 10 39839 482 79704057
Medication error 26.47 12.47 85 39764 68557 79635982
Pain 26.40 12.47 225 39624 703577 79000962
Pulmonary congestion 26.30 12.47 48 39801 27052 79677487
Cyanosis 26.23 12.47 46 39803 25136 79679403
Acute respiratory failure 26.00 12.47 77 39772 59464 79645075
Supraventricular extrasystoles 25.76 12.47 24 39825 6963 79697576
Drug ineffective 25.44 12.47 384 39465 1080529 78624010
Neuropathy peripheral 25.41 12.47 20 39829 141285 79563254
Acute kidney injury 25.30 12.47 154 39695 519250 79185289
Ligament pain 25.15 12.47 8 39841 250 79704289
Kyphosis 24.97 12.47 16 39833 2675 79701864
Pleural rub 24.90 12.47 6 39843 64 79704475
Arteriosclerosis coronary artery 24.62 12.47 37 39812 17779 79686760
Pancytopenia 24.50 12.47 28 39821 165717 79538822
Heart rate increased 24.29 12.47 122 39727 120602 79583937
Respiratory tract congestion 24.17 12.47 39 39810 19915 79684624
Wolff-Parkinson-White syndrome 23.89 12.47 8 39841 295 79704244
Swelling 23.83 12.47 45 39804 216666 79487873
Eosinophilic pneumonia chronic 23.20 12.47 9 39840 509 79704030
Arthralgia 23.16 12.47 179 39670 571624 79132915
Dyspnoea at rest 23.00 12.47 23 39826 7279 79697260
Cushingoid 22.85 12.47 26 39823 9526 79695013
Overdose 22.83 12.47 164 39685 184042 79520497
Adrenal suppression 22.82 12.47 12 39837 1387 79703152
Flail chest 22.49 12.47 6 39843 99 79704440
Gastrointestinal disorder 22.35 12.47 17 39832 122188 79582351
Seizure 22.19 12.47 166 39683 188668 79515871
Helicobacter infection 22.19 12.47 4 39845 69700 79634839
Lung perforation 22.05 12.47 6 39843 107 79704432
Paranasal sinus hypersecretion 21.98 12.47 17 39832 3829 79700710
Total lung capacity abnormal 21.70 12.47 7 39842 229 79704310
Blood bicarbonate decreased 21.43 12.47 19 39830 5172 79699367
Drug level above therapeutic 21.30 12.47 24 39825 8699 79695840
Stress cardiomyopathy 21.16 12.47 27 39822 11139 79693400
Viral infection 21.08 12.47 58 39791 42958 79661581
Clonic convulsion 21.08 12.47 11 39838 1251 79703288
Allergic cough 20.54 12.47 9 39840 694 79703845
Product use in unapproved indication 20.34 12.47 61 39788 250298 79454241
Generalised tonic-clonic seizure 20.34 12.47 58 39791 43852 79660687
Ankle fracture 20.33 12.47 33 39816 16936 79687603
Tachyarrhythmia 20.24 12.47 21 39828 6941 79697598
Tonic convulsion 20.11 12.47 13 39836 2207 79702332
Eye paraesthesia 19.84 12.47 6 39843 158 79704381
Gastric atony 19.81 12.47 3 39846 0 79704539
Antasthmatic drug level above therapeutic 19.81 12.47 3 39846 0 79704539
Breast conserving surgery 19.54 12.47 9 39840 781 79703758
Death 19.51 12.47 185 39664 566329 79138210
Sputum increased 19.28 12.47 17 39832 4596 79699943
Eosinophilic pneumonia 19.12 12.47 18 39831 5292 79699247
Pertussis 18.66 12.47 9 39840 866 79703673
Perfume sensitivity 18.62 12.47 9 39840 870 79703669
Electrocardiogram ST segment depression 18.46 12.47 17 39832 4861 79699678
Eosinophilia 18.26 12.47 57 39792 45288 79659251
Ocular discomfort 18.15 12.47 17 39832 4966 79699573
Ventricular extrasystoles 17.99 12.47 34 39815 19670 79684869
Presbyacusis 17.98 12.47 13 39836 2647 79701892
Thoracic operation 17.92 12.47 6 39843 221 79704318
Left ventricular failure 17.89 12.47 23 39826 9558 79694981
Status epilepticus 17.86 12.47 39 39810 25002 79679537
Bronchitis chronic 17.70 12.47 16 39833 4466 79700073
Increased bronchial secretion 17.49 12.47 14 39835 3313 79701226
White blood cell count decreased 17.45 12.47 43 39806 188245 79516294
Stevens-Johnson syndrome 17.43 12.47 51 39798 39115 79665424
Oesophagogastroduodenoscopy 17.43 12.47 6 39843 241 79704298
Chest pain 17.16 12.47 216 39633 282088 79422451
Completed suicide 17.14 12.47 64 39785 245703 79458836
Crepitations 17.08 12.47 23 39826 9994 79694545
Nasal septum deviation 17.04 12.47 11 39838 1862 79702677
Pulmonary artery dilatation 17.01 12.47 7 39842 462 79704077
Toxic epidermal necrolysis 17.00 12.47 55 39794 44526 79660013
Musculoskeletal stiffness 16.99 12.47 39 39810 174969 79529570
Septic shock 16.82 12.47 22 39827 122779 79581760
Post streptococcal glomerulonephritis 16.74 12.47 5 39844 126 79704413
Glaucoma 16.70 12.47 33 39816 19728 79684811
Sudden infant death syndrome 16.59 12.47 6 39843 279 79704260
Bronchitis 16.58 12.47 117 39732 130527 79574012
Hypokalaemia 16.57 12.47 126 39723 143914 79560625
Drug intolerance 16.40 12.47 72 39777 264047 79440492
Lung neoplasm malignant 16.21 12.47 40 39809 27752 79676787
Fibromyalgia 16.09 12.47 6 39843 64334 79640205
Oxygen saturation decreased 16.04 12.47 115 39734 128932 79575607
Injection site hypoaesthesia 16.01 12.47 7 39842 537 79704002
Enterobacter pneumonia 15.98 12.47 5 39844 148 79704391
Nasal polyps 15.95 12.47 19 39830 7308 79697231
Paraesthesia 15.77 12.47 41 39808 176282 79528257
Disease progression 15.64 12.47 44 39805 184318 79520221
Diabetes mellitus 15.61 12.47 79 39770 78311 79626228
Sputum abnormal 15.54 12.47 9 39840 1256 79703283
Lipid metabolism disorder 15.40 12.47 6 39843 343 79704196
Ventricular tachycardia 15.33 12.47 51 39798 41884 79662655
Latent tuberculosis 15.31 12.47 13 39836 3340 79701199
Irritable bowel syndrome 15.24 12.47 6 39843 62235 79642304
Haematochezia 15.02 12.47 13 39836 87632 79616907
Macrocytosis 14.93 12.47 12 39837 2858 79701681
Respiratory symptom 14.92 12.47 15 39834 4776 79699763
Leukopenia 14.83 12.47 22 39827 116491 79588048
Peripheral swelling 14.69 12.47 77 39772 269540 79434999
Ventricular arrhythmia 14.62 12.47 20 39829 8820 79695719
Hypoxia 14.62 12.47 95 39754 103148 79601391
Night sweats 14.55 12.47 4 39845 52091 79652448
Neoplasm progression 14.37 12.47 4 39845 51678 79652861
Deep vein thrombosis 14.28 12.47 24 39825 120895 79583644
Upper respiratory tract infection 14.22 12.47 86 39763 91082 79613457
Multiple sclerosis relapse 14.12 12.47 3 39846 46530 79658009
Bronchitis bacterial 14.11 12.47 9 39840 1493 79703046
Malaise 14.06 12.47 332 39517 489537 79215002
Stenotrophomonas infection 13.99 12.47 13 39836 3760 79700779
Vaccination site haemorrhage 13.98 12.47 3 39846 18 79704521
Dermatitis allergic 13.81 12.47 29 39820 18101 79686438
Burns third degree 13.79 12.47 6 39843 455 79704084
Duodenal ulcer perforation 13.74 12.47 8 39841 66203 79638336
Stress 13.65 12.47 77 39772 79535 79625004
Ill-defined disorder 13.61 12.47 8 39841 65867 79638672
Urinary tract infection 13.54 12.47 81 39768 274431 79430108
Psoriasis 13.38 12.47 15 39834 89572 79614967
Hyperventilation 13.26 12.47 18 39831 7881 79696658
Lung neoplasm 13.25 12.47 17 39832 7052 79697487
Hyperkalaemia 13.24 12.47 23 39826 114375 79590164
Diabetes mellitus inadequate control 13.19 12.47 34 39815 24230 79680309
Pulmonary mass 13.10 12.47 38 39811 28996 79675543
Dry skin 13.03 12.47 9 39840 67986 79636553
Contraindicated product prescribed 12.99 12.47 9 39840 1712 79702827
Alanine aminotransferase increased 12.92 12.47 40 39809 162530 79542009
Food allergy 12.90 12.47 21 39828 10803 79693736
Haemophilus infection 12.88 12.47 10 39839 2266 79702273
Platelet count decreased 12.73 12.47 52 39797 194612 79509927
Transaminases increased 12.65 12.47 5 39844 51738 79652801
Dizziness exertional 12.53 12.47 6 39843 568 79703971
Respiratory alkalosis 12.52 12.47 13 39836 4298 79700241

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DA04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC R03DA05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC R03DA54 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC R03DA55 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC R03DA74 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines
ATC R03DB04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines and adrenergics
ATC R03DB05 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Xanthines and adrenergics
FDA CS M0023046 Xanthines
CHEBI has role CHEBI:35523 bronchodilator
CHEBI has role CHEBI:38147 cardiotonic drugs
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D020011 Protective Agents
MeSH PA D058914 Purinergic Antagonists
MeSH PA D058915 Purinergic P1 Receptor Antagonists
MeSH PA D019141 Respiratory System Agents
MeSH PA D014665 Vasodilator Agents
FDA EPC N0000175790 Methylxanthine
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50218 phosphodiesterase inhibitors
CHEBI has role CHEBI:50846 Immunologic factor
CHEBI has role CHEBI:51371 muscle relaxants
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:71232 adenosine receptor antagonists
CHEBI has role CHEBI:76946 fungal metabolites
CHEBI has role CHEBI:85234 human blood serum metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchospasm indication 4386001
Disorder of lung indication 19829001 DOID:850
Bronchitis indication 32398004 DOID:6132
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841
Asthma night-time symptoms indication 395022009
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Asthma-chronic obstructive pulmonary disease overlap syndrome indication 10692761000119107
COPD Associated with Chronic Bronchitis indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Apnea in the newborn off-label use 13094009
Neonatal Mixed Apnea off-label use
Goiter contraindication 3716002 DOID:12176
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Pulmonary edema contraindication 19242006 DOID:11396
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Third trimester pregnancy contraindication 41587001
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Multiple organ failure contraindication 57653000
Hepatic failure contraindication 59927004
Poisoning by phenobarbital contraindication 64921004
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Seizure disorder contraindication 128613002
Cystic fibrosis contraindication 190905008 DOID:1485
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Sepsis syndrome contraindication 238150007
Hypocomplementemic urticarial vasculitis contraindication 239945009
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Smoking cessation assistance contraindication 384742004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Porphyria contraindication 418470004
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.46 acidic
pKa2 3.01 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Enzyme INHIBITOR Ki 3.85 WOMBAT-PK CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme INHIBITOR Ki 4.11 WOMBAT-PK CHEMBL
Adenosine receptor A1 GPCR ANTAGONIST Ki 9.22 CHEMBL CHEMBL
Adenosine receptor A2b GPCR ANTAGONIST Ki 5.57 CHEMBL CHEMBL
Adenosine receptor A2a GPCR ANTAGONIST Ki 9.22 CHEMBL CHEMBL
Transmembrane domain-containing protein TMIGD3 Unclassified Ki 4.06 CHEMBL
Adenosine receptor A3 GPCR ANTAGONIST Ki 7.85 CHEMBL
Alkaline phosphatase, tissue-nonspecific isozyme Enzyme Ki 4.09 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Kinase IC50 4.12 CHEMBL
Adenosine receptor A2a GPCR Ki 5.17 CHEMBL
Uncharacterized protein Enzyme Ki 4.11 CHEMBL
Adenosine receptor A3 GPCR Ki 4.07 CHEMBL
Adenosine receptor A1 GPCR Ki 5.42 CHEMBL
Adenosine receptor A1 GPCR Ki 5.01 CHEMBL
Adenosine A2 receptor GPCR Ki 5.88 CHEMBL
Adenosine A2b receptor GPCR Ki 4.82 CHEMBL
Adenosine receptor GPCR Ki 4.70 CHEMBL
Heart phosphodiesterase Enzyme IC50 4.04 CHEMBL
Adenosine A2a receptor GPCR Ki 4.89 CHEMBL
Adenosine receptor A2b GPCR ANTAGONIST Ki 5.25 IUPHAR
Adenosine receptor A1 GPCR Ki 6.15 CHEMBL

External reference:

IDSource
4018056 VUID
N0000146397 NUI
D00227 KEGG_DRUG
317-34-0 SECONDARY_CAS_RN
5897-66-5 SECONDARY_CAS_RN
4018055 VANDF
4018056 VANDF
4018129 VANDF
4018130 VANDF
4018132 VANDF
C0039771 UMLSCUI
CHEBI:28177 CHEBI
TEP PDB_CHEM_ID
CHEMBL190 ChEMBL_ID
DB00277 DRUGBANK_ID
CHEMBL1370561 ChEMBL_ID
D013806 MESH_DESCRIPTOR_UI
2153 PUBCHEM_CID
413 IUPHAR_LIGAND_ID
8000-10-0 SECONDARY_CAS_RN
C137DTR5RG UNII
DB01223 DRUGBANK_ID
10438 RXNORM
2086 MMSL
3058 MMSL
4172 MMSL
4173 MMSL
4175 MMSL
5563 MMSL
5564 MMSL
674 MMSL
72114 MMSL
72147 MMSL
d00142 MMSL
d00758 MMSL
000602 NDDF
000603 NDDF
000607 NDDF
000608 NDDF
111131008 SNOMEDCT_US
372810006 SNOMEDCT_US
373508009 SNOMEDCT_US
387431001 SNOMEDCT_US
45940009 SNOMEDCT_US
55867006 SNOMEDCT_US
66493003 SNOMEDCT_US
D000628 MESH_DESCRIPTOR_UI
D031210 MESH_DESCRIPTOR_UI
CHEMBL1200578 ChEMBL_ID
376 INN_ID
5967-84-0 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
THEOPHYLLINE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0820 SOLUTION 80 mg ORAL ANDA 25 sections
THEOPHYLLINE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0820 SOLUTION 80 mg ORAL ANDA 25 sections
THEOPHYLLINE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0820 SOLUTION 80 mg ORAL ANDA 25 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 0121-4794 SOLUTION 80 mg ORAL ANDA 25 sections
THEOPHYLLINE HUMAN PRESCRIPTION DRUG LABEL 1 0121-4820 SOLUTION 80 mg ORAL ANDA 25 sections
THEOPHYLLINE HUMAN PRESCRIPTION DRUG LABEL 1 0121-4820 SOLUTION 80 mg ORAL ANDA 25 sections
THEOPHYLLINE HUMAN PRESCRIPTION DRUG LABEL 1 0121-4820 SOLUTION 80 mg ORAL ANDA 25 sections
Theophylline in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9554 INJECTION, SOLUTION 80 mg INTRAVENOUS NDA 27 sections
Theophylline(Anhydrous) HUMAN PRESCRIPTION DRUG LABEL 1 0378-0486 TABLET, EXTENDED RELEASE 400 mg ORAL ANDA 22 sections
Theophylline(Anhydrous) HUMAN PRESCRIPTION DRUG LABEL 1 0378-0487 TABLET, EXTENDED RELEASE 600 mg ORAL ANDA 22 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0404-9813 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 12 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0404-9813 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 12 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0404-9814 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 12 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0404-9814 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 12 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0404-9814 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 12 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0409-5921 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 22 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0409-5921 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 22 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0409-5922 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 22 sections
Aminophylline HUMAN PRESCRIPTION DRUG LABEL 1 0409-5922 INJECTION, SOLUTION 25 mg INTRAVENOUS ANDA 22 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 0480-3309 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 22 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 0480-3309 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 22 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 0480-3310 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 22 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 0480-3310 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 22 sections
Theophylline Extended Release HUMAN PRESCRIPTION DRUG LABEL 1 0615-1590 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 23 sections
Theophylline Extended Release HUMAN PRESCRIPTION DRUG LABEL 1 0615-2503 TABLET, EXTENDED RELEASE 200 mg ORAL ANDA 23 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 10135-604 SOLUTION 80 mg ORAL ANDA 22 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 17856-0038 SOLUTION 80 mg ORAL ANDA 13 sections
ELIXOPHYLLIN Human Prescription Drug Label 1 17856-0644 LIQUID 80 mg ORAL ANDA 21 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 23155-741 TABLET, EXTENDED RELEASE 300 mg ORAL ANDA 12 sections
Theophylline HUMAN PRESCRIPTION DRUG LABEL 1 23155-742 TABLET, EXTENDED RELEASE 450 mg ORAL ANDA 12 sections