All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

temazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	2585	846-50-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: temazepam (RS)-Temazepam levanxene levanxol	A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. Molecular weight: 300.74 Formula: C16H13ClN2O2 CLOGP: 2.34 LIPINSKI: 0 HAC: 4 HDO: 1 TPSA: 52.90 ALOGS: -3.75 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
20	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.60 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.83 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	91 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Feb. 27, 1981	FDA	MALLINCKRODT INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	451.90	10.06	583	52705	145090	63290644
Toxicity to various agents	399.57	10.06	731	52557	246519	63189215
Temperature regulation disorder	324.47	10.06	139	53149	5993	63429741
Coeliac disease	248.52	10.06	147	53141	12650	63423084
Food allergy	248.05	10.06	141	53147	11260	63424474
Overdose	232.36	10.06	376	52912	114702	63321032
Immunodeficiency	178.69	10.06	143	53145	20111	63415623
Hyperhidrosis	156.47	10.06	305	52983	107531	63328203
Pemphigus	139.60	10.06	3	53285	183723	63252011
Rash erythematous	126.59	10.06	167	53121	42343	63393391
Bursitis	125.25	10.06	155	53133	36886	63398848
Synovitis	122.37	10.06	9	53279	186909	63248825
Fluid retention	116.25	10.06	192	53096	59494	63376240
Hand deformity	109.36	10.06	6	53282	159451	63276283
Respiratory arrest	107.80	10.06	135	53153	32510	63403224
Maternal exposure during pregnancy	106.02	10.06	27	53261	220035	63215699
Drug ineffective	99.08	10.06	497	52791	1044268	62391466
Arthropathy	95.12	10.06	39	53249	234753	63200981
Glossodynia	89.98	10.06	20	53268	178856	63256878
Anti-cyclic citrullinated peptide antibody positive	84.18	10.06	3	53285	116209	63319525
Wound	82.63	10.06	18	53270	163245	63272489
Systemic lupus erythematosus	82.54	10.06	36	53252	208882	63226852
Myocardial depression	81.51	10.06	26	53262	478	63435256
Constipation	79.93	10.06	387	52901	224556	63211178
Swelling	75.40	10.06	72	53216	275306	63160428
Off label use	75.00	10.06	302	52986	674160	62761574
Pericarditis	74.16	10.06	11	53277	131568	63304166
Drug intolerance	72.08	10.06	92	53196	308569	63127165
Decorticate posture	71.67	10.06	21	53267	286	63435448
Back pain	70.42	10.06	420	52868	263725	63172009
Abdominal discomfort	69.53	10.06	101	53187	320784	63114950
Cardiac arrest	67.92	10.06	201	53087	92344	63343390
Discomfort	67.44	10.06	28	53260	167346	63268388
Upper respiratory tract infection	66.81	10.06	185	53103	81862	63353872
Poisoning	64.38	10.06	68	53220	13632	63422102
Asthma	62.59	10.06	242	53046	127319	63308415
Accidental overdose	58.00	10.06	84	53204	23225	63412509
Libido increased	56.69	10.06	26	53262	1319	63434415
Rectal polyp	55.54	10.06	25	53263	1214	63434520
Rheumatoid factor positive	55.39	10.06	4	53284	84402	63351332
Respiratory depression	53.93	10.06	62	53226	13653	63422081
Cardio-respiratory arrest	53.64	10.06	140	53148	59819	63375915
Drug abuse	52.72	10.06	157	53131	72361	63363373
Victim of sexual abuse	51.59	10.06	20	53268	664	63435070
Hostility	51.37	10.06	27	53261	1845	63433889
Substance abuse	49.04	10.06	37	53251	4770	63430964
Alopecia	48.44	10.06	135	53153	337401	63098333
Therapeutic product effect decreased	47.79	10.06	55	53233	193132	63242602
Arthralgia	45.52	10.06	286	53002	569424	62866310
Duodenal ulcer perforation	45.37	10.06	9	53279	87200	63348534
Judgement impaired	44.47	10.06	19	53269	813	63434921
Folliculitis	44.28	10.06	4	53284	70313	63365421
Rash	42.55	10.06	286	53002	560585	62875149
Infusion related reaction	42.48	10.06	89	53199	245432	63190302
Change of bowel habit	42.07	10.06	25	53263	2168	63433566
Sternal fracture	41.43	10.06	25	53263	2229	63433505
Post-traumatic neck syndrome	40.72	10.06	24	53264	2050	63433684
Venous pressure jugular increased	40.45	10.06	16	53272	561	63435173
Coma scale abnormal	40.44	10.06	34	53254	5119	63430615
Soft tissue injury	40.20	10.06	22	53266	1630	63434104
Duodenal ulcer	39.14	10.06	40	53248	7716	63428018
Therapeutic product effect incomplete	37.44	10.06	30	53258	125026	63310708
Anxiety	37.37	10.06	311	52977	217230	63218504
Amblyopia	35.82	10.06	12	53276	259	63435475
Hypothermia	35.34	10.06	50	53238	13531	63422203
Intentional overdose	34.98	10.06	139	53149	74013	63361721
Insomnia	34.48	10.06	303	52985	214949	63220785
Impaired reasoning	34.20	10.06	9	53279	80	63435654
Peripheral swelling	34.09	10.06	112	53176	265830	63169904
Transplant dysfunction	33.88	10.06	30	53258	4842	63430892
Intestinal haemorrhage	33.57	10.06	27	53261	3820	63431914
Drug withdrawal syndrome	33.56	10.06	72	53216	27122	63408612
Intentional product use issue	33.17	10.06	35	53253	127857	63307877
Infected dermal cyst	32.91	10.06	13	53275	454	63435280
Mass	32.73	10.06	49	53239	13951	63421783
Psoriatic arthropathy	32.73	10.06	18	53270	91502	63344232
Sensitisation	32.21	10.06	25	53263	3361	63432373
Nasopharyngitis	31.96	10.06	108	53180	254149	63181585
Suicidal ideation	31.88	10.06	120	53168	62301	63373433
Musculoskeletal stiffness	31.02	10.06	68	53220	184550	63251184
Tremor	30.63	10.06	203	53085	132036	63303698
Toxicologic test abnormal	30.59	10.06	14	53274	707	63435027
Urine odour abnormal	30.53	10.06	32	53256	6357	63429377
Infection	30.42	10.06	95	53193	229078	63206656
Liver injury	29.94	10.06	7	53281	60513	63375221
Blister	29.93	10.06	39	53249	129775	63305959
Proctalgia	29.91	10.06	31	53257	6079	63429655
Frustration tolerance decreased	29.88	10.06	33	53255	6955	63428779
Intentional product misuse	29.38	10.06	115	53173	60802	63374932
Somnolence	29.37	10.06	253	53035	178432	63257302
General physical health deterioration	29.27	10.06	80	53208	201322	63234412
Thiopurine methyltransferase decreased	29.24	10.06	11	53277	336	63435398
Kyphosis	29.17	10.06	21	53267	2519	63433215
Accidental death	28.99	10.06	19	53269	1957	63433777
Injection site discomfort	27.31	10.06	26	53262	4604	63431130
Somnambulism	26.91	10.06	28	53260	5515	63430219
Gastrointestinal disorder	26.75	10.06	43	53245	131196	63304538
Dehydration	26.71	10.06	242	53046	173112	63262622
Rectal prolapse	26.52	10.06	18	53270	1965	63433769
Unresponsive to stimuli	26.28	10.06	75	53213	33741	63401993
Nightmare	26.24	10.06	53	53235	19141	63416593
Apnoea	26.19	10.06	33	53255	7989	63427745
Stomatitis	25.95	10.06	48	53240	138677	63297057
Withdrawal syndrome	25.90	10.06	54	53234	19943	63415791
Personality disorder	25.82	10.06	28	53260	5783	63429951
Mental disorder	25.76	10.06	63	53225	25856	63409878
Rheumatic fever	25.72	10.06	3	53285	43108	63392626
Postmortem blood drug level	25.72	10.06	8	53280	135	63435599
Exposure during pregnancy	25.55	10.06	58	53230	155489	63280245
Treatment failure	25.37	10.06	84	53204	198959	63236775
Ill-defined disorder	25.24	10.06	19	53269	81736	63353998
Miosis	25.21	10.06	31	53257	7322	63428412
Band neutrophil percentage increased	25.11	10.06	9	53279	239	63435495
Poor quality sleep	24.85	10.06	53	53235	19882	63415852
Furuncle	24.67	10.06	29	53259	6537	63429197
Muscle injury	24.63	10.06	12	53276	65333	63370401
Neutropenia	24.33	10.06	71	53217	174934	63260800
Foetal death	23.65	10.06	37	53251	10943	63424791
Arteriosclerosis coronary artery	23.54	10.06	32	53256	8341	63427393
Antidepressant drug level above therapeutic	23.42	10.06	10	53278	427	63435307
Irritable bowel syndrome	23.16	10.06	21	53267	82391	63353343
Myelocyte percentage increased	22.55	10.06	8	53280	206	63435528
Depression	22.46	10.06	258	53030	196234	63239500
Peripheral coldness	22.16	10.06	38	53250	12127	63423607
Knee arthroplasty	21.93	10.06	9	53279	54197	63381537
Joint swelling	21.92	10.06	173	53115	327493	63108241
Panic attack	21.90	10.06	54	53234	22277	63413457
Ventricular hypokinesia	21.73	10.06	23	53265	4621	63431113
Polyp	21.57	10.06	27	53261	6494	63429240
Musculoskeletal discomfort	21.52	10.06	47	53241	17920	63417814
Irritability	21.51	10.06	67	53221	31627	63404107
C-reactive protein increased	21.27	10.06	29	53259	94678	63341056
Homicide	21.27	10.06	9	53279	376	63435358
Band neutrophil count increased	21.04	10.06	9	53279	386	63435348
Condition aggravated	21.02	10.06	226	53062	401991	63033743
Urine oxalate increased	20.97	10.06	8	53280	254	63435480
Hip arthroplasty	20.80	10.06	7	53281	47639	63388095
Oesophagitis ulcerative	20.53	10.06	10	53278	581	63435153
Diabetes mellitus	20.47	10.06	97	53191	55713	63380021
Bladder disorder	20.47	10.06	31	53257	8915	63426819
Helicobacter infection	20.25	10.06	29	53259	92756	63342978
Abnormal behaviour	20.16	10.06	51	53237	21375	63414359
Retinal depigmentation	20.10	10.06	8	53280	285	63435449
Urine abnormality	20.00	10.06	27	53261	6992	63428742
Analgesic drug level above therapeutic	19.89	10.06	7	53281	176	63435558
Bundle branch block left	19.88	10.06	27	53261	7032	63428702
Blood glucose decreased	19.84	10.06	50	53238	20902	63414832
Urticaria	19.76	10.06	72	53216	165730	63270004
Interstitial lung disease	19.61	10.06	14	53274	61894	63373840
Contraindicated product administered	19.59	10.06	105	53183	217543	63218191
Prescribed overdose	19.42	10.06	68	53220	34085	63401649
Stress	19.27	10.06	109	53179	67058	63368676
Death	19.23	10.06	430	52858	373951	63061783
Hypovolaemia	18.99	10.06	33	53255	10640	63425094
Drug dependence	18.73	10.06	54	53234	24429	63411305
Hyperthermia	18.55	10.06	30	53258	9126	63426608
Suspected product quality issue	18.48	10.06	7	53281	218	63435516
Myelocyte count increased	18.30	10.06	8	53280	362	63435372
Loss of consciousness	18.23	10.06	165	53123	117956	63317778
Mental impairment	18.08	10.06	38	53250	14113	63421621
Dystrophic calcification	17.97	10.06	6	53282	128	63435606
Cardiac failure congestive	17.95	10.06	136	53152	92297	63343437
Sinusitis	17.92	10.06	114	53174	226539	63209195
Mobility decreased	17.68	10.06	48	53240	121111	63314623
Potentiating drug interaction	17.65	10.06	20	53268	4336	63431398
Rib fracture	17.44	10.06	50	53238	22547	63413187
Ovarian cyst	17.19	10.06	40	53248	15905	63419829
Erythema	17.14	10.06	224	53064	175527	63260207
Pulmonary congestion	16.95	10.06	42	53246	17376	63418358
Homicidal ideation	16.80	10.06	13	53275	1739	63433995
Upper respiratory tract congestion	16.76	10.06	14	53274	2088	63433646
Mood swings	16.71	10.06	43	53245	18205	63417529
Atrioventricular block first degree	16.35	10.06	25	53263	7248	63428486
Thyroid disorder	16.30	10.06	38	53250	15124	63420610
Injection site erythema	16.25	10.06	28	53260	83146	63352588
Postoperative wound infection	15.94	10.06	31	53257	10894	63424840
Febrile neutropenia	15.77	10.06	49	53239	118400	63317334
Bruxism	15.69	10.06	17	53271	3508	63432226
Rebound psychosis	15.69	10.06	6	53282	192	63435542
Depressed mood	15.58	10.06	71	53217	40120	63395614
Urinary incontinence	15.08	10.06	60	53228	31954	63403780
Transplant rejection	15.01	10.06	30	53258	10750	63424984
COVID-19	14.91	10.06	47	53241	113056	63322678
Pruritus	14.77	10.06	214	53074	361239	63074495
Suspected counterfeit product	14.75	10.06	7	53281	384	63435350
Product use in unapproved indication	14.70	10.06	89	53199	178991	63256743
Calculus urethral	14.65	10.06	3	53285	7	63435727
Postmortem blood drug level increased	14.58	10.06	8	53280	596	63435138
Abortion spontaneous	14.53	10.06	11	53277	47184	63388550
Mania	14.41	10.06	32	53256	12335	63423399
Monocyte percentage increased	14.36	10.06	10	53278	1138	63434596
Limb discomfort	14.25	10.06	56	53232	29660	63406074
Dysgeusia	14.19	10.06	77	53211	46633	63389101
Poisoning deliberate	14.19	10.06	30	53258	11188	63424546
Bacterial test	14.16	10.06	10	53278	1164	63434570
Dysuria	14.14	10.06	61	53227	33677	63402057
Fall	14.13	10.06	430	52858	391904	63043830
Victim of crime	14.12	10.06	5	53283	128	63435606
Lung disorder	14.05	10.06	19	53269	62242	63373492
Premature delivery	14.02	10.06	4	53284	30277	63405457
Arteriosclerosis	14.00	10.06	28	53260	10038	63425696
Middle insomnia	13.94	10.06	32	53256	12611	63423123
Hepatocellular injury	13.88	10.06	3	53285	27378	63408356
Respiratory alkalosis	13.76	10.06	14	53274	2687	63433047
Haemorrhage	13.71	10.06	93	53195	60929	63374805
Cardioactive drug level above therapeutic	13.57	10.06	5	53283	144	63435590
Flight of ideas	13.47	10.06	7	53281	467	63435267
Needle issue	13.41	10.06	28	53260	10348	63425386
Akathisia	13.40	10.06	26	53262	9120	63426614
Dilatation atrial	13.33	10.06	12	53276	1979	63433755
Memory impairment	13.32	10.06	140	53148	104118	63331616
Impaired healing	13.25	10.06	43	53245	102499	63333235
Concussion	13.20	10.06	26	53262	9218	63426516
Chronic obstructive pulmonary disease	13.18	10.06	94	53194	62592	63373142
Gallbladder disorder	12.94	10.06	40	53248	18802	63416932
Specific gravity urine decreased	12.66	10.06	8	53280	774	63434960
Microscopic polyangiitis	12.36	10.06	5	53283	186	63435548
Exostosis	12.34	10.06	38	53250	17824	63417910
Peptic ulcer perforation	12.31	10.06	5	53283	188	63435546
Food interaction	12.16	10.06	8	53280	830	63434904
Blood glucose fluctuation	12.13	10.06	17	53271	4559	63431175
Acquired immunodeficiency syndrome	12.00	10.06	4	53284	85	63435649
Clonus	11.96	10.06	17	53271	4619	63431115
Psychotic disorder	11.96	10.06	48	53240	25664	63410070
Bipolar I disorder	11.84	10.06	11	53277	1888	63433846
Subendocardial ischaemia	11.83	10.06	4	53284	89	63435645
Leukopenia	11.75	10.06	30	53258	77260	63358474
Septic shock	11.63	10.06	24	53264	66605	63369129
Feeling abnormal	11.61	10.06	182	53106	148210	63287524
Drug reaction with eosinophilia and systemic symptoms	11.60	10.06	7	53281	33829	63401905
Post-traumatic pain	11.23	10.06	6	53282	424	63435310
Exposure via ingestion	11.18	10.06	13	53275	2896	63432838
Stoma site discomfort	11.10	10.06	4	53284	108	63435626
Underdose	11.02	10.06	49	53239	27407	63408327
Amnesia	10.91	10.06	82	53206	55503	63380231
Bone disorder	10.89	10.06	41	53247	21285	63414449
Live birth	10.79	10.06	4	53284	25626	63410108
Blood albumin decreased	10.75	10.06	32	53256	14734	63421000
Pressure of speech	10.70	10.06	7	53281	719	63435015
Respiratory rate decreased	10.69	10.06	14	53274	3521	63432213
Posturing	10.36	10.06	6	53282	496	63435238
Urinary tract infection	10.30	10.06	293	52995	264391	63171343
Deafness bilateral	10.27	10.06	9	53279	1433	63434301
Renal infarct	10.24	10.06	9	53279	1438	63434296
Cholestasis	10.22	10.06	6	53282	29428	63406306
Labelled drug-drug interaction issue	10.19	10.06	8	53280	1093	63434641
Monoplegia	10.18	10.06	13	53275	3188	63432546

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	691.98	11.61	862	29814	199500	34726755
Completed suicide	346.18	11.61	428	30248	97740	34828515
Drug abuse	217.11	11.61	344	30332	98752	34827503
Poisoning	116.53	11.61	92	30584	12134	34914121
Overdose	113.24	11.61	248	30428	90811	34835444
Aggression	112.19	11.61	154	30522	38810	34887445
Dysarthria	102.44	11.61	139	30537	34643	34891612
Intrusive thoughts	101.59	11.61	28	30648	287	34925968
Off label use	84.25	11.61	150	30526	419374	34506881
Substance abuse	80.44	11.61	61	30615	7580	34918675
Drug dependence	79.35	11.61	102	30574	24115	34902140
Tachyphrenia	73.25	11.61	31	30645	1238	34925017
Logorrhoea	70.80	11.61	37	30639	2389	34923866
Suicidal ideation	70.67	11.61	127	30549	40261	34885994
Bradyphrenia	65.85	11.61	45	30631	4753	34921502
Homicidal ideation	64.57	11.61	36	30640	2646	34923609
Suicide attempt	62.15	11.61	118	30558	38998	34887257
Psychotic disorder	56.31	11.61	87	30589	24365	34901890
Dystonic tremor	54.95	11.61	16	30660	203	34926052
Depressed level of consciousness	54.67	11.61	118	30558	42723	34883532
Accidental overdose	48.27	11.61	73	30603	20067	34906188
Loss of libido	47.52	11.61	29	30647	2523	34923732
Abnormal behaviour	45.57	11.61	80	30596	24889	34901366
Bradykinesia	45.27	11.61	33	30643	3860	34922395
Insomnia	44.59	11.61	195	30481	103712	34822543
Sedation	44.58	11.61	72	30604	20934	34905321
Pulmonary congestion	43.55	11.61	57	30619	13708	34912547
Respiratory depression	43.43	11.61	62	30614	16183	34910072
Anxiety	42.97	11.61	187	30489	99241	34827014
Anger	40.41	11.61	51	30625	11833	34914422
Injury	38.68	11.61	67	30609	20620	34905635
Restlessness	36.96	11.61	74	30602	25408	34900847
Coordination abnormal	36.38	11.61	39	30637	7605	34918650
Hallucination, auditory	35.63	11.61	48	30628	11869	34914386
Drug ineffective	35.12	11.61	246	30430	456505	34469750
Behaviour disorder	34.49	11.61	31	30645	4879	34921376
Mood swings	33.60	11.61	38	30638	7863	34918392
Drug level below therapeutic	32.81	11.61	32	30644	5583	34920672
Irritability	32.63	11.61	69	30607	24621	34901634
Mental disorder	32.09	11.61	52	30624	15157	34911098
Accidental poisoning	31.81	11.61	15	30661	775	34925480
Paranoia	30.71	11.61	45	30631	12023	34914232
Needle fatigue	30.26	11.61	15	30661	866	34925389
Restless legs syndrome	30.24	11.61	37	30639	8317	34917938
Emotional distress	29.85	11.61	50	30626	14976	34911279
Feelings of worthlessness	29.66	11.61	11	30665	308	34925947
Drug interaction	29.32	11.61	315	30361	225631	34700624
Miosis	27.89	11.61	38	30638	9497	34916758
Relapsing-remitting multiple sclerosis	27.77	11.61	15	30661	1035	34925220
Gait spastic	27.17	11.61	15	30661	1081	34925174
Psychotic behaviour	27.14	11.61	13	30663	696	34925559
Fear	26.57	11.61	39	30637	10437	34915818
Drug withdrawal syndrome	25.71	11.61	55	30621	19779	34906476
Withdrawal syndrome	25.49	11.61	42	30634	12413	34913842
Crystalluria	25.29	11.61	11	30665	470	34925785
Thinking abnormal	25.22	11.61	29	30647	6108	34920147
Depression	24.86	11.61	158	30518	96940	34829315
Hypertonic bladder	24.44	11.61	17	30659	1847	34924408
Obsessive-compulsive disorder	24.07	11.61	27	30649	5537	34920718
Agitation	24.04	11.61	107	30569	57292	34868963
Dissociation	23.82	11.61	16	30660	1642	34924613
COVID-19	23.60	11.61	20	30656	77530	34848725
Depressed mood	23.26	11.61	52	30624	19265	34906990
Cardio-respiratory arrest	23.12	11.61	103	30573	55170	34871085
General physical health deterioration	22.88	11.61	49	30627	128220	34798035
Mesothelioma	22.82	11.61	10	30666	435	34925820
Congestive hepatopathy	22.00	11.61	16	30660	1865	34924390
Arteriosclerosis coronary artery	21.49	11.61	39	30637	12446	34913809
Homicide	20.85	11.61	12	30664	937	34925318
Febrile neutropenia	20.68	11.61	57	30619	136792	34789463
Drug abuser	20.28	11.61	21	30655	3933	34922322
Osmolar gap abnormal	20.22	11.61	5	30671	32	34926223
Emotional disorder	20.18	11.61	25	30651	5691	34920564
Abulia	19.97	11.61	10	30666	590	34925665
Memory impairment	19.86	11.61	83	30593	43235	34883020
Interstitial lung disease	19.66	11.61	17	30659	65265	34860990
Panic attack	19.56	11.61	32	30644	9400	34916855
Antasthmatic drug level	19.25	11.61	5	30671	40	34926215
Analgesic drug level	18.93	11.61	5	30671	43	34926212
Somnambulism	18.88	11.61	18	30658	3054	34923201
Monoparesis	18.87	11.61	16	30660	2330	34923925
Drug screen positive	18.55	11.61	20	30656	3923	34922332
Cardiac asthma	18.03	11.61	7	30669	223	34926032
Somnolence	17.82	11.61	162	30514	110954	34815301
Personality change	17.38	11.61	22	30654	5117	34921138
Amnesia	17.30	11.61	57	30619	26506	34899749
Pulmonary oedema	17.26	11.61	85	30591	47444	34878811
Depersonalisation/derealisation disorder	17.16	11.61	9	30667	585	34925670
Decreased interest	16.77	11.61	15	30661	2345	34923910
Confusional state	16.40	11.61	196	30480	143964	34782291
Joint swelling	16.39	11.61	17	30659	59873	34866382
Intentional product use issue	16.35	11.61	17	30659	59799	34866456
Conduction disorder	16.18	11.61	14	30662	2096	34924159
Dissociative disorder	16.15	11.61	8	30668	461	34925794
Sexually transmitted disease	16.12	11.61	4	30672	26	34926229
Patient uncooperative	16.05	11.61	8	30668	467	34925788
Blood disorder	15.76	11.61	17	30659	3337	34922918
Thalassaemia	15.51	11.61	4	30672	31	34926224
Hepatic function abnormal	15.35	11.61	10	30666	44353	34881902
Renal impairment	15.31	11.61	38	30638	94475	34831780
Lethargy	15.25	11.61	74	30602	41048	34885207
Diarrhoea	15.15	11.61	246	30430	389666	34536589
Muscle spasticity	15.04	11.61	22	30654	5866	34920389
Pyrexia	14.68	11.61	205	30471	332808	34593447
Victim of crime	14.59	11.61	7	30669	376	34925879
Reduced facial expression	14.42	11.61	10	30666	1081	34925174
Unresponsive to stimuli	14.38	11.61	55	30621	27514	34898741
Accidental death	14.35	11.61	14	30662	2442	34923813
Physical disability	14.35	11.61	11	30665	1388	34924867
Vestibular disorder	14.29	11.61	10	30666	1097	34925158
Nervousness	14.14	11.61	33	30643	12573	34913682
Tangentiality	14.13	11.61	5	30671	122	34926133
Gun shot wound	14.12	11.61	10	30666	1118	34925137
Nocturia	14.03	11.61	29	30647	10181	34916074
Foetal exposure during pregnancy	14.00	11.61	8	30668	38093	34888162
Exposure via ingestion	13.82	11.61	13	30663	2168	34924087
Gait disturbance	13.57	11.61	124	30552	85016	34841239
Adjustment disorder	13.56	11.61	10	30666	1191	34925064
Cerebral arteriovenous malformation haemorrhagic	13.51	11.61	4	30672	54	34926201
Condition aggravated	13.49	11.61	106	30570	192090	34734165
Hallucination, visual	13.26	11.61	40	30636	17751	34908504
Iron metabolism disorder	13.18	11.61	4	30672	59	34926196
Treatment failure	13.07	11.61	13	30663	46684	34879571
Contraindication to medical treatment	13.02	11.61	8	30668	704	34925551
Acute kidney injury	12.99	11.61	189	30487	304799	34621456
Dysprosody	12.76	11.61	3	30673	15	34926240
Cardiomegaly	12.74	11.61	36	30640	15402	34910853
Sexually inappropriate behaviour	12.67	11.61	7	30669	505	34925750
Inappropriate schedule of product administration	12.66	11.61	22	30654	62274	34863981
Cognitive disorder	12.39	11.61	54	30622	28639	34897616
Multiple organ dysfunction syndrome	12.23	11.61	31	30645	76535	34849720
Micturition urgency	12.02	11.61	21	30655	6504	34919751
Cytomegalovirus infection	11.96	11.61	4	30672	26131	34900124
Hospitalisation	11.65	11.61	20	30656	56882	34869373

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	991.48	10.19	1494	67216	420046	79255632
Completed suicide	822.37	10.19	1034	67676	244733	79430945
Temperature regulation disorder	317.24	10.19	136	68574	5717	79669961
Overdose	305.95	10.19	560	68150	183646	79492032
Drug abuse	264.30	10.19	490	68220	162201	79513477
Coeliac disease	250.50	10.19	143	68567	11208	79664470
Food allergy	232.55	10.19	134	68576	10690	79664988
Poisoning	179.03	10.19	159	68551	25113	79650565
Immunodeficiency	156.27	10.19	138	68572	21630	79654048
Substance abuse	130.27	10.19	92	68618	10434	79665244
Off label use	126.61	10.19	383	68327	906832	78768846
Bursitis	121.22	10.19	152	68558	35692	79639986
Accidental overdose	103.43	10.19	148	68562	39433	79636245
Respiratory arrest	103.07	10.19	181	68529	57369	79618309
Respiratory depression	101.23	10.19	122	68588	27508	79648170
Synovitis	99.69	10.19	8	68702	150726	79524952
Aggression	97.45	10.19	165	68545	50793	79624885
Fluid retention	97.00	10.19	197	68513	69612	79606066
Drug ineffective	95.95	10.19	544	68166	1080369	78595309
Hyperhidrosis	95.06	10.19	317	68393	151175	79524503
Rash erythematous	87.46	10.19	169	68541	57600	79618078
Myocardial depression	83.66	10.19	27	68683	502	79675176
Drug dependence	81.95	10.19	135	68575	40634	79635044
Death	81.10	10.19	794	67916	565720	79109958
Cardio-respiratory arrest	79.91	10.19	240	68470	108270	79567408
Intrusive thoughts	79.84	10.19	26	68684	498	79675180
Dysarthria	79.16	10.19	178	68532	67444	79608234
Pemphigus	72.79	10.19	3	68707	99579	79576099
Homicidal ideation	72.13	10.19	42	68668	3415	79672263
Suicidal ideation	70.13	10.19	183	68527	76157	79599521
Decorticate posture	68.89	10.19	21	68689	321	79675357
Maternal exposure during pregnancy	67.83	10.19	17	68693	136521	79539157
Hand deformity	67.37	10.19	6	68704	103913	79571765
Arthropathy	66.17	10.19	35	68675	177076	79498602
Tachyphrenia	64.93	10.19	33	68677	2047	79673631
Logorrhoea	63.12	10.19	42	68668	4323	79671355
Abnormal behaviour	61.93	10.19	112	68598	36309	79639369
Pulmonary congestion	60.30	10.19	94	68616	27006	79648672
Anti-cyclic citrullinated peptide antibody positive	59.15	10.19	3	68707	83140	79592538
Irritability	57.01	10.19	116	68594	41028	79634650
Discomfort	56.24	10.19	19	68691	125598	79550080
Cardiac arrest	55.67	10.19	294	68416	171802	79503876
Dystonic tremor	55.23	10.19	16	68694	203	79675475
Miosis	53.44	10.19	67	68643	15722	79659956
Mental disorder	52.89	10.19	96	68614	31206	79644472
Victim of sexual abuse	52.23	10.19	19	68691	513	79675165
General physical health deterioration	51.81	10.19	99	68611	275139	79400539
Insomnia	49.94	10.19	372	68338	244798	79430880
Back pain	49.24	10.19	438	68272	303742	79371936
Intentional overdose	49.01	10.19	201	68509	105759	79569919
Drug intolerance	48.84	10.19	96	68614	264023	79411655
Arthralgia	48.23	10.19	292	68418	571511	79104167
Swelling	48.14	10.19	70	68640	216641	79459037
Suicide attempt	48.00	10.19	169	68541	82763	79592915
Rectal polyp	47.72	10.19	25	68685	1652	79674026
Judgement impaired	47.63	10.19	23	68687	1277	79674401
Mood swings	47.11	10.19	71	68639	19809	79655869
Loss of libido	46.65	10.19	29	68681	2656	79673022
Libido increased	46.28	10.19	26	68684	1975	79673703
Pericarditis	46.25	10.19	16	68694	104220	79571458
Asthma	45.90	10.19	234	68476	134861	79540817
Psychotic disorder	45.15	10.19	106	68604	41296	79634382
Upper respiratory tract infection	44.60	10.19	176	68534	90992	79584686
Depressed level of consciousness	44.43	10.19	183	68527	96469	79579209
Arteriosclerosis coronary artery	44.18	10.19	65	68645	17751	79657927
Homicide	43.51	10.19	21	68689	1165	79674513
Behaviour disorder	43.27	10.19	39	68671	6274	79669404
Coma scale abnormal	43.25	10.19	45	68665	8633	79667045
Hostility	42.81	10.19	26	68684	2284	79673394
Intentional product use issue	42.48	10.19	41	68669	152071	79523607
Bradyphrenia	42.31	10.19	49	68661	10591	79665087
Anxiety	41.84	10.19	361	68349	248151	79427527
Soft tissue injury	40.81	10.19	23	68687	1758	79673920
Sternal fracture	40.63	10.19	26	68684	2504	79673174
Withdrawal syndrome	39.95	10.19	78	68632	26776	79648902
Post-traumatic neck syndrome	39.92	10.19	24	68686	2070	79673608
Interstitial lung disease	39.53	10.19	24	68686	112576	79563102
Peripheral swelling	39.44	10.19	111	68599	269506	79406172
Glossodynia	39.21	10.19	20	68690	103317	79572361
Change of bowel habit	38.60	10.19	26	68684	2731	79672947
Somnolence	38.08	10.19	343	68367	238638	79437040
Restlessness	37.24	10.19	106	68604	46386	79629292
Constipation	37.13	10.19	390	68320	282660	79393018
Depression	36.52	10.19	315	68395	216475	79459203
Accidental death	36.51	10.19	30	68680	4261	79671417
Drug withdrawal syndrome	35.82	10.19	87	68623	34631	79641047
Unresponsive to stimuli	35.18	10.19	117	68593	55671	79620007
Rheumatoid factor positive	34.91	10.19	5	68705	59834	79615844
Rash	34.63	10.19	325	68385	578033	79097645
Gait spastic	34.50	10.19	18	68692	1179	79674499
Bradykinesia	33.60	10.19	38	68672	8005	79667673
Systemic lupus erythematosus	33.42	10.19	33	68677	121116	79554562
Paranoia	33.34	10.19	60	68650	19372	79656306
Drug abuser	33.29	10.19	33	68677	5980	79669698
Sedation	32.87	10.19	109	68601	51786	79623892
Memory impairment	32.82	10.19	186	68524	111548	79564130
Amblyopia	32.57	10.19	11	68699	237	79675441
Abdominal discomfort	32.55	10.19	109	68601	250618	79425060
Nasopharyngitis	32.53	10.19	111	68599	253770	79421908
Sensitisation	32.12	10.19	25	68685	3286	79672392
Kyphosis	32.10	10.19	23	68687	2668	79673010
Impaired reasoning	32.08	10.19	9	68701	101	79675577
Folliculitis	31.45	10.19	5	68705	55375	79620303
Infusion related reaction	31.34	10.19	98	68612	230139	79445539
COVID-19	31.17	10.19	55	68655	157619	79518059
Urine odour abnormal	30.32	10.19	32	68678	6241	79669437
Febrile neutropenia	30.28	10.19	100	68610	230899	79444779
Needle fatigue	30.18	10.19	15	68695	887	79674791
Therapeutic product effect decreased	29.89	10.19	60	68650	163803	79511875
Toxicologic test abnormal	29.64	10.19	17	68693	1343	79674335
Coordination abnormal	29.12	10.19	53	68657	17259	79658419
Duodenal ulcer	28.67	10.19	51	68659	16318	79659360
Victim of crime	28.64	10.19	12	68698	476	79675202
Neutropenia	28.57	10.19	139	68571	287571	79388107
Thiopurine methyltransferase decreased	28.39	10.19	11	68699	355	79675323
Wound	28.35	10.19	35	68675	116144	79559534
Condition aggravated	28.13	10.19	286	68424	500838	79174840
Duodenal ulcer perforation	27.96	10.19	11	68699	66200	79609478
Drug screen positive	27.67	10.19	30	68680	6033	79669645
Frustration tolerance decreased	27.27	10.19	33	68677	7469	79668209
Venous pressure jugular increased	27.22	10.19	16	68694	1324	79674354
Intentional product misuse	27.02	10.19	157	68553	95008	79580670
Poor quality sleep	26.79	10.19	60	68650	22662	79653016
Mental impairment	26.76	10.19	54	68656	18982	79656696
Rib fracture	26.69	10.19	68	68642	27879	79647799
Transplant dysfunction	26.63	10.19	32	68678	7189	79668489
Depressed mood	26.52	10.19	97	68613	48383	79627295
Urticaria	26.51	10.19	77	68633	185124	79490554
Mass	26.29	10.19	51	68659	17421	79658257
Cytomegalovirus infection	26.24	10.19	3	68707	42641	79633037
Blister	26.12	10.19	39	68671	119437	79556241
Personality disorder	25.61	10.19	29	68681	6117	79669561
Hepatocellular injury	25.50	10.19	5	68705	47588	79628090
Relapsing-remitting multiple sclerosis	25.37	10.19	16	68694	1503	79674175
Obsessive-compulsive disorder	24.76	10.19	28	68682	5899	79669779
Rectal prolapse	24.58	10.19	18	68692	2160	79673518
Anger	24.50	10.19	49	68661	17113	79658565
Myelosuppression	24.38	10.19	3	68707	40293	79635385
Injection site discomfort	24.34	10.19	26	68684	5140	79670538
Exposure via ingestion	24.31	10.19	26	68684	5148	79670530
Psoriatic arthropathy	24.22	10.19	19	68691	77980	79597698
Proctalgia	24.09	10.19	36	68674	9965	79665713
Foetal death	23.89	10.19	32	68678	8012	79667666
Restless legs syndrome	23.62	10.19	53	68657	20039	79655639
Acute kidney injury	23.48	10.19	311	68399	519093	79156585
Pruritus	23.06	10.19	223	68487	394425	79281253
Thinking abnormal	23.04	10.19	41	68669	13120	79662558
Liver injury	22.94	10.19	10	68700	56604	79619074
Pulmonary oedema	22.76	10.19	142	68568	88112	79587566
Infection	22.72	10.19	119	68591	241593	79434085
Stomatitis	22.51	10.19	59	68651	146698	79528980
Apnoea	22.50	10.19	38	68672	11666	79664012
Blood glucose decreased	22.17	10.19	61	68649	26173	79649505
Somnambulism	22.17	10.19	26	68684	5695	79669983
Bruxism	22.11	10.19	22	68688	4004	79671674
Musculoskeletal stiffness	22.08	10.19	77	68633	174931	79500747
C-reactive protein increased	22.06	10.19	49	68661	128978	79546700
Accidental poisoning	21.71	10.19	15	68695	1642	79674036
Alopecia	21.69	10.19	114	68596	231241	79444437
Psychotic behaviour	21.68	10.19	13	68697	1116	79674562
Intestinal haemorrhage	21.32	10.19	27	68683	6399	79669279
Urine oxalate increased	21.16	10.19	8	68702	241	79675437
Emotional distress	21.05	10.19	79	68631	39890	79635788
Myelocyte percentage increased	21.01	10.19	8	68702	246	79675432
Feelings of worthlessness	20.93	10.19	10	68700	542	79675136
Therapeutic product effect incomplete	20.93	10.19	58	68652	141587	79534091
Delusion	20.87	10.19	51	68659	20372	79655306
Furuncle	20.84	10.19	29	68681	7525	79668153
Polyp	20.71	10.19	30	68680	8077	79667601
Diarrhoea	20.52	10.19	590	68120	879899	78795779
Mobility decreased	20.40	10.19	47	68663	122128	79553550
Ovarian cyst	20.35	10.19	38	68672	12617	79663061
Hypothermia	20.34	10.19	54	68656	22692	79652986
Poisoning deliberate	20.30	10.19	48	68662	18780	79656898
Panic attack	20.16	10.19	56	68654	24160	79651518
Band neutrophil percentage increased	20.10	10.19	9	68701	420	79675258
Cardiomegaly	20.06	10.19	59	68651	26293	79649385
Tremor	19.82	10.19	229	68481	169854	79505824
Loss of consciousness	19.51	10.19	226	68484	167717	79507961
Antasthmatic drug level	19.34	10.19	5	68705	40	79675638
Septic shock	19.11	10.19	49	68661	122752	79552926
Retinal depigmentation	19.10	10.19	8	68702	317	79675361
Antidepressant drug level above therapeutic	19.01	10.19	10	68700	666	79675012
Urine abnormality	18.97	10.19	29	68681	8190	79667488
Analgesic drug level	18.81	10.19	5	68705	45	79675633
Postmortem blood drug level	18.57	10.19	8	68702	340	79675338
Knee arthroplasty	18.57	10.19	7	68703	43241	79632437
Sinusitis	18.51	10.19	96	68614	195405	79480273
Agitation	18.43	10.19	148	68562	99567	79576111
Prescribed overdose	18.41	10.19	73	68637	37810	79637868
Crystalluria	18.39	10.19	11	68699	940	79674738
Dilatation atrial	18.09	10.19	19	68691	3685	79671993
Infected dermal cyst	17.94	10.19	12	68698	1246	79674432
Amnesia	17.88	10.19	104	68606	62953	79612725
Hepatic function abnormal	17.86	10.19	22	68688	73085	79602593
Drug resistance	17.84	10.19	7	68703	42206	79633472
Hypertonic bladder	17.81	10.19	20	68690	4181	79671497
Iron metabolism disorder	17.67	10.19	5	68705	58	79675620
Dystrophic calcification	17.60	10.19	6	68704	133	79675545
Feeling abnormal	17.51	10.19	212	68498	158987	79516691
Lethargy	17.47	10.19	125	68585	81167	79594511
Joint swelling	17.32	10.19	162	68548	288484	79387194
Alcohol poisoning	17.19	10.19	21	68689	4800	79670878
Cholestasis	17.07	10.19	12	68698	52097	79623581
Pyrexia	17.02	10.19	450	68260	678259	78997419
Mania	16.99	10.19	44	68666	18216	79657462
Nightmare	16.98	10.19	55	68655	25806	79649872
Ill-defined disorder	16.98	10.19	19	68691	65856	79609822
Congestive hepatopathy	16.52	10.19	20	68690	4527	79671151
Decreased interest	16.36	10.19	18	68692	3679	79671999
Pneumocystis jirovecii pneumonia	16.23	10.19	4	68706	32504	79643174
Movement disorder	16.15	10.19	56	68654	27203	79648475
Band neutrophil count increased	16.05	10.19	9	68701	681	79674997
Irritable bowel syndrome	15.99	10.19	18	68692	62223	79613455
Gastrointestinal disorder	15.93	10.19	53	68657	122152	79553526
Fibrinolysis	15.70	10.19	5	68705	89	79675589
Akathisia	15.61	10.19	35	68675	13224	79662454
Fear	15.58	10.19	48	68662	21938	79653740
Treatment failure	15.42	10.19	85	68625	170401	79505277
Monoparesis	15.37	10.19	17	68693	3494	79672184
Bladder disorder	15.34	10.19	28	68682	9137	79666541
Rheumatic fever	15.27	10.19	3	68707	28522	79647156
Osmolar gap abnormal	15.25	10.19	5	68705	98	79675580
Abulia	15.20	10.19	10	68700	1010	79674668
Anaemia	15.17	10.19	281	68429	444734	79230944
Drug interaction	15.03	10.19	466	68244	414717	79260961
Rebound psychosis	14.87	10.19	7	68703	367	79675311
Product use in unapproved indication	14.80	10.19	141	68569	250218	79425460
Postmortem blood drug level increased	14.72	10.19	9	68701	800	79674878
Herpes zoster	14.59	10.19	37	68673	93046	79582632
Hallucination, auditory	14.50	10.19	45	68665	20648	79655030
Mucosal inflammation	14.36	10.19	27	68683	75553	79600125
Hospitalisation	14.36	10.19	38	68672	94198	79581480
Bundle branch block left	14.25	10.19	31	68679	11482	79664196
Flight of ideas	14.20	10.19	9	68701	853	79674825
Upper respiratory tract congestion	13.88	10.19	14	68696	2589	79673089
Ventricular hypokinesia	13.86	10.19	27	68683	9252	79666426
Pancytopenia	13.73	10.19	85	68625	165660	79510018
Emotional disorder	13.73	10.19	35	68675	14352	79661326
Oesophagitis ulcerative	13.70	10.19	10	68700	1193	79674485
Blood pressure fluctuation	13.65	10.19	23	68687	67122	79608556
Bacterial test	13.56	10.19	10	68700	1213	79674465
Pressure of speech	13.52	10.19	10	68700	1218	79674460
Concussion	13.41	10.19	27	68683	9476	79666202
Micturition urgency	13.38	10.19	32	68678	12609	79663069
Drug eruption	13.27	10.19	11	68699	43924	79631754
Thalassaemia	13.25	10.19	4	68706	59	79675619
Cardiac asthma	13.18	10.19	6	68704	291	79675387
Thyroid disorder	13.18	10.19	34	68676	14045	79661633
Patient uncooperative	13.14	10.19	8	68702	706	79674972
Arteriosclerosis	13.11	10.19	40	68670	18187	79657491
Analgesic drug level above therapeutic	13.09	10.19	7	68703	482	79675196
Opiates positive	12.95	10.19	9	68701	995	79674683
Seasonal affective disorder	12.92	10.19	6	68704	305	79675373
Cardiomyopathy	12.84	10.19	54	68656	28720	79646958
Dysprosody	12.81	10.19	3	68707	15	79675663
Neurotoxicity	12.78	10.19	6	68704	32512	79643166
Nocturia	12.76	10.19	33	68677	13648	79662030
Lip swelling	12.66	10.19	10	68700	40901	79634777
Thrombocytopenia	12.63	10.19	157	68553	265102	79410576
Myelocyte count increased	12.59	10.19	8	68702	761	79674917
Coronary artery disease	12.55	10.19	98	68612	65376	79610302
Breast cancer male	12.53	10.19	6	68704	327	79675351
Muscle injury	12.52	10.19	14	68696	48547	79627131
Sexually inappropriate behaviour	12.38	10.19	7	68703	538	79675140
Chronic obstructive pulmonary disease	12.28	10.19	120	68590	85299	79590379
Tangentiality	12.26	10.19	5	68705	185	79675493
Transaminases increased	12.19	10.19	16	68694	51727	79623951
Impaired healing	12.14	10.19	37	68673	87618	79588060
Dissociative disorder	12.11	10.19	8	68702	813	79674865
Multiple sclerosis relapse	12.07	10.19	75	68635	46458	79629220
Mesothelioma	12.02	10.19	6	68704	358	79675320
Musculoskeletal discomfort	11.97	10.19	41	68669	19794	79655884
Hypovolaemia	11.96	10.19	38	68672	17653	79658025
Suspected counterfeit product	11.91	10.19	7	68703	579	79675099
Lung disorder	11.88	10.19	33	68677	80524	79595154
Gun shot wound	11.71	10.19	9	68701	1161	79674517
Asphyxia	11.69	10.19	29	68681	11691	79663987
Gallbladder disorder	11.69	10.19	40	68670	19300	79656378
Hyperlipidaemia	11.66	10.19	49	68661	26044	79649634
Dehydration	11.63	10.19	288	68422	247899	79427779
Specific gravity urine decreased	11.63	10.19	8	68702	870	79674808
Cyclothymic disorder	11.60	10.19	5	68705	213	79675465
Intentional product misuse to child	11.56	10.19	4	68706	93	79675585
Peripheral coldness	11.44	10.19	35	68675	15935	79659743
Ventricular hypertrophy	11.37	10.19	21	68689	6917	79668761
Hypokalaemia	11.35	10.19	75	68635	143965	79531713
Schizophrenia	11.21	10.19	34	68676	15406	79660272
Exostosis	11.20	10.19	36	68674	16822	79658856
Accident	11.18	10.19	24	68686	8807	79666871
Exposure during pregnancy	11.14	10.19	47	68663	101085	79574593
Bone disorder	11.10	10.19	39	68671	19074	79656604
Conduction disorder	10.90	10.19	14	68696	3365	79672313
Gamma-glutamyltransferase increased	10.87	10.19	19	68691	54661	79621017
Injection site erythema	10.83	10.19	33	68677	78164	79597514
Cardioactive drug level above therapeutic	10.83	10.19	5	68705	251	79675427
Inappropriate schedule of product administration	10.82	10.19	69	68641	133559	79542119
Postoperative wound infection	10.82	10.19	30	68680	12931	79662747
Abortion spontaneous	10.76	10.19	6	68704	29501	79646177
Therapy non-responder	10.73	10.19	42	68668	92263	79583415
Inflammation	10.68	10.19	43	68667	93710	79581968
Fall	10.67	10.19	518	68192	487111	79188567
Subendocardial ischaemia	10.66	10.19	4	68706	118	79675560
Mental status changes	10.59	10.19	96	68614	66863	79608815
Bipolar I disorder	10.54	10.19	11	68699	2118	79673560
Hepatic steatosis	10.54	10.19	62	68648	37676	79638002
Middle insomnia	10.39	10.19	34	68676	16035	79659643
Erectile dysfunction	10.37	10.19	32	68678	14632	79661046
Grip strength decreased	10.33	10.19	3	68707	21866	79653812
Arrhythmia	10.28	10.19	89	68621	61183	79614495

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05CD07	NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
FDA EPC	N0000175694	Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Insomnia	indication	193462001
Suicidal thoughts	contraindication	6471006
Alcohol intoxication	contraindication	25702006
Depressive disorder	contraindication	35489007
Substance abuse	contraindication	66214007
Sleep apnea	contraindication	73430006	DOID:0050847
Kidney disease	contraindication	90708001	DOID:557
Hypoalbuminemia	contraindication	119247004
Disease of liver	contraindication	235856003	DOID:409
Sleep automatism	contraindication	247962006
Pregnancy, function	contraindication	289908002
Severe chronic obstructive pulmonary disease	contraindication	313299006
Memory impairment	contraindication	386807006
Chronic lung disease	contraindication	413839001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.07	acidic
pKa2	1.46	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR				WOMBAT-PK	CHEMBL
Nuclear receptor subfamily 1 group I member 3	Nuclear hormone receptor	Q14994	NR1I3_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017894	VUID
N0000146246	NUI
D00370	KEGG_DRUG
4017894	VANDF
C0039468	UMLSCUI
CHEBI:9435	CHEBI
CHEMBL967	ChEMBL_ID
DB00231	DRUGBANK_ID
D013693	MESH_DESCRIPTOR_UI
5391	PUBCHEM_CID
7300	IUPHAR_LIGAND_ID
2753	INN_ID
CHB1QD2QSS	UNII
10355	RXNORM
2322	MMSL
5544	MMSL
d00384	MMSL
001450	NDDF
387300007	SNOMEDCT_US
54705000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2076	CAPSULE	15 mg	ORAL	ANDA	19 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2076	CAPSULE	15 mg	ORAL	ANDA	19 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2077	CAPSULE	30 mg	ORAL	ANDA	19 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2077	CAPSULE	30 mg	ORAL	ANDA	19 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9914	CAPSULE	22.50 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9914	CAPSULE	22.50 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9915	CAPSULE	7.50 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9915	CAPSULE	7.50 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9916	CAPSULE	15 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9916	CAPSULE	15 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9917	CAPSULE	30 mg	ORAL	NDA	26 sections
RESTORIL	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9917	CAPSULE	30 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9959	CAPSULE	22.50 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9959	CAPSULE	22.50 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9960	CAPSULE	7.50 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9960	CAPSULE	7.50 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9961	CAPSULE	15 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9961	CAPSULE	15 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9962	CAPSULE	30 mg	ORAL	NDA	26 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9962	CAPSULE	30 mg	ORAL	NDA	26 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7808	CAPSULE	15 mg	ORAL	ANDA	27 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7809	CAPSULE	30 mg	ORAL	ANDA	27 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6436	CAPSULE	7.50 mg	ORAL	ANDA	24 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6436	CAPSULE	7.50 mg	ORAL	ANDA	24 sections
TEMAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-214	CAPSULE	15 mg	ORAL	ANDA	14 sections
temazepam	Human Prescription Drug Label	1	17856-0148	CAPSULE	15 mg	ORAL	ANDA	23 sections
temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	21695-282	CAPSULE	15 mg	ORAL	ANDA	24 sections
temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	21695-283	CAPSULE	30 mg	ORAL	ANDA	24 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	33261-101	CAPSULE	15 mg	ORAL	ANDA	23 sections
Temazepam	HUMAN PRESCRIPTION DRUG LABEL	1	33261-102	CAPSULE	30 mg	ORAL	ANDA	23 sections