temazepam ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 2585 846-50-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • temazepam
  • (RS)-Temazepam
  • levanxene
  • levanxol
A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.
  • Molecular weight: 300.74
  • Formula: C16H13ClN2O2
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 52.90
  • ALOGS: -3.75
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.60 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.83 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 91 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 1981 FDA MALLINCKRODT INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 388.87 10.39 548 47406 131341 50425829
Toxicity to various agents 358.70 10.39 686 47268 211813 50345357
Temperature regulation disorder 235.55 10.39 103 47851 4124 50553046
Coeliac disease 188.74 10.39 112 47842 8573 50548597
Overdose 176.48 10.39 329 47625 99398 50457772
Food allergy 174.39 10.39 104 47850 8033 50549137
Immunodeficiency 124.36 10.39 107 47847 14721 50542449
Bursitis 105.17 10.39 117 47837 22018 50535152
Hyperhidrosis 102.25 10.39 247 47707 89179 50467991
Drug ineffective 99.69 10.39 420 47534 818913 49738257
Maternal exposure during pregnancy 99.64 10.39 16 47938 159762 50397408
Respiratory arrest 99.18 10.39 132 47822 29877 50527293
Synovitis 96.73 10.39 5 47949 123860 50433310
Drug intolerance 86.70 10.39 50 47904 219054 50338116
Hand deformity 81.67 10.39 3 47951 100196 50456974
Myocardial depression 81.30 10.39 26 47928 424 50556746
Rash erythematous 81.26 10.39 130 47824 34722 50522448
Off label use 79.56 10.39 211 47743 474215 50082955
Fluid retention 76.00 10.39 156 47798 50493 50506677
Decorticate posture 69.43 10.39 21 47933 282 50556888
Arthropathy 66.89 10.39 33 47921 157873 50399297
Poisoning 63.03 10.39 68 47886 12361 50544809
Cardiac arrest 62.67 10.39 198 47756 83453 50473717
Glossodynia 60.94 10.39 17 47937 115552 50441618
Constipation 59.52 10.39 339 47615 185369 50371801
Wound 58.77 10.39 14 47940 105780 50451390
Systemic lupus erythematosus 58.63 10.39 30 47924 140592 50416578
Accidental overdose 58.60 10.39 82 47872 19451 50537719
Infusion related reaction 57.28 10.39 46 47908 169511 50387659
Asthma 55.02 10.39 198 47756 89139 50468031
Abdominal discomfort 55.01 10.39 84 47870 231557 50325613
Swelling 53.55 10.39 67 47887 200805 50356365
Drug abuse 52.70 10.39 150 47804 59696 50497474
Libido increased 49.53 10.39 24 47930 1219 50555951
Pericarditis 48.76 10.39 8 47946 78681 50478489
Exposure during pregnancy 47.28 10.39 28 47926 120987 50436183
Hostility 46.78 10.39 26 47928 1756 50555414
Back pain 46.46 10.39 362 47592 219668 50337502
Substance abuse 45.65 10.39 35 47919 4089 50553081
Discomfort 45.35 10.39 23 47931 108357 50448813
Rash 44.81 10.39 238 47716 437233 50119937
Respiratory depression 44.63 10.39 56 47898 11954 50545216
Cardio-respiratory arrest 44.49 10.39 132 47822 53760 50503410
Treatment failure 44.43 10.39 39 47915 137598 50419572
Upper respiratory tract infection 42.23 10.39 148 47806 65750 50491420
Arthralgia 40.43 10.39 247 47707 438455 50118715
Victim of sexual abuse 40.15 10.39 16 47938 505 50556665
Venous pressure jugular increased 39.34 10.39 16 47938 533 50556637
Coma scale abnormal 39.13 10.39 34 47920 4737 50552433
Sternal fracture 38.81 10.39 24 47930 1978 50555192
Post-traumatic neck syndrome 37.29 10.39 23 47931 1887 50555283
Soft tissue injury 37.19 10.39 21 47933 1463 50555707
Anxiety 35.71 10.39 289 47665 177317 50379853
Insomnia 35.41 10.39 285 47669 174580 50382590
Joint swelling 35.26 10.39 117 47837 245169 50312001
Peripheral swelling 34.84 10.39 91 47863 205845 50351325
Impaired reasoning 34.07 10.39 9 47945 71 50557099
Hypothermia 33.91 10.39 49 47905 11967 50545203
Transplant dysfunction 31.77 10.39 30 47924 4654 50552516
Infected dermal cyst 31.74 10.39 13 47941 441 50556729
Amblyopia 31.72 10.39 11 47943 233 50556937
Therapeutic product effect decreased 29.77 10.39 52 47902 135998 50421172
Alopecia 29.30 10.39 126 47828 244921 50312249
Kyphosis 28.80 10.39 21 47933 2274 50554896
Judgement impaired 28.66 10.39 13 47941 568 50556602
Suicidal ideation 28.52 10.39 116 47838 55269 50501901
Therapeutic product effect incomplete 28.25 10.39 27 47927 91488 50465682
Personality disorder 28.01 10.39 27 47927 4297 50552873
Toxicologic test abnormal 27.79 10.39 13 47941 610 50556560
Intentional overdose 27.64 10.39 125 47829 62379 50494791
Drug withdrawal syndrome 27.27 10.39 68 47886 25013 50532157
Apnoea 26.71 10.39 33 47921 6933 50550237
Folliculitis 26.63 10.39 3 47951 39222 50517948
Rectal prolapse 26.59 10.39 18 47936 1731 50555439
Thiopurine methyltransferase decreased 25.76 10.39 10 47944 294 50556876
Duodenal ulcer perforation 25.39 10.39 6 47948 45605 50511565
Somnambulism 25.07 10.39 27 47927 4897 50552273
Band neutrophil percentage increased 25.06 10.39 9 47945 212 50556958
Miosis 24.37 10.39 30 47924 6280 50550890
Contraindicated product administered 24.29 10.39 67 47887 148891 50408279
Tremor 24.18 10.39 189 47765 114714 50442456
Somnolence 23.85 10.39 238 47716 154747 50402423
Depression 23.54 10.39 250 47704 165173 50391997
Ventricular hypokinesia 22.36 10.39 23 47931 3957 50553213
Nightmare 22.31 10.39 48 47906 16038 50541132
Panic attack 21.62 10.39 53 47901 19289 50537881
Myelocyte percentage increased 21.60 10.39 8 47946 206 50556964
Oesophagitis ulcerative 21.40 10.39 10 47944 468 50556702
Nasopharyngitis 21.37 10.39 102 47852 192825 50364345
Infection 21.23 10.39 88 47866 172866 50384304
Mental disorder 21.21 10.39 57 47897 21934 50535236
Poor quality sleep 21.20 10.39 48 47906 16598 50540572
Band neutrophil count increased 21.02 10.39 9 47945 342 50556828
Neutropenia 20.95 10.39 71 47883 147894 50409276
Urine oxalate increased 20.81 10.39 8 47946 229 50556941
Withdrawal syndrome 20.52 10.39 49 47905 17541 50539629
Homicide 20.51 10.39 9 47945 363 50556807
Muscle injury 20.42 10.39 5 47949 37106 50520064
Bundle branch block left 19.96 10.39 27 47927 6203 50550967
Rectal polyp 19.85 10.39 12 47942 949 50556221
Gastrointestinal disorder 19.85 10.39 37 47917 94419 50462751
Accidental death 19.74 10.39 15 47939 1729 50555441
Retinal depigmentation 19.46 10.39 8 47946 274 50556896
Blister 19.27 10.39 32 47922 85386 50471784
Analgesic drug level above therapeutic 19.21 10.39 7 47947 172 50556998
Poisoning deliberate 19.10 10.39 30 47924 7882 50549288
Unresponsive to stimuli 18.96 10.39 68 47886 30541 50526629
Musculoskeletal stiffness 18.63 10.39 61 47893 128420 50428750
Interstitial lung disease 18.47 10.39 14 47940 53162 50504008
Suspected product quality issue 18.29 10.39 7 47947 198 50556972
Duodenal ulcer 18.21 10.39 27 47927 6748 50550422
Intentional product use issue 18.12 10.39 28 47926 76890 50480280
Dystrophic calcification 18.01 10.39 6 47948 112 50557058
Myelocyte count increased 17.73 10.39 8 47946 345 50556825
Stomatitis 17.72 10.39 44 47910 101300 50455870
Hypovolaemia 17.68 10.39 32 47922 9433 50547737
Ovarian cyst 17.43 10.39 40 47914 13956 50543214
Depressed mood 17.31 10.39 71 47883 33952 50523218
Pulmonary congestion 17.27 10.39 42 47912 15205 50541965
Arteriosclerosis coronary artery 17.13 10.39 28 47926 7608 50549562
Atrioventricular block first degree 17.08 10.39 25 47929 6176 50550994
Dehydration 17.06 10.39 220 47734 152229 50404941
Abnormal behaviour 17.03 10.39 49 47905 19609 50537561
Injection site erythema 16.97 10.39 28 47926 74908 50482262
Ill-defined disorder 15.87 10.39 17 47937 54637 50502533
C-reactive protein increased 15.85 10.39 24 47930 66450 50490720
Urticaria 15.84 10.39 66 47888 129495 50427675
Irritability 15.81 10.39 61 47893 28365 50528805
Rib fracture 15.78 10.39 47 47907 19174 50537996
Homicidal ideation 15.75 10.39 13 47941 1689 50555481
Psoriatic arthropathy 15.56 10.39 13 47941 47019 50510151
Mass 15.42 10.39 35 47919 12122 50545048
Middle insomnia 15.39 10.39 31 47923 9890 50547280
Suspected counterfeit product 15.32 10.39 7 47947 311 50556859
Hepatocellular injury 15.28 10.39 3 47951 25944 50531226
Cardiac failure congestive 15.18 10.39 134 47820 84248 50472922
Helicobacter infection 14.95 10.39 15 47939 49687 50507483
Upper respiratory tract congestion 14.93 10.39 13 47941 1816 50555354
Transplant rejection 14.88 10.39 30 47924 9579 50547591
General physical health deterioration 14.79 10.39 77 47877 142357 50414813
Abortion spontaneous 14.51 10.39 11 47943 41761 50515409
Sensitisation 14.46 10.39 12 47942 1570 50555600
Bruxism 14.32 10.39 16 47938 3024 50554146
Calculus urethral 14.28 10.39 3 47951 7 50557163
Memory impairment 14.26 10.39 126 47828 79234 50477936
Monocyte percentage increased 14.15 10.39 10 47944 1031 50556139
Mood swings 14.04 10.39 40 47914 15914 50541256
Loss of consciousness 14.04 10.39 156 47798 104197 50452973
Postmortem blood drug level increased 13.95 10.39 8 47946 574 50556596
Dysgeusia 13.74 10.39 73 47881 38843 50518327
Febrile neutropenia 13.73 10.39 47 47907 97620 50459550
Arteriosclerosis 13.65 10.39 28 47926 9049 50548121
Amnesia 13.40 10.39 77 47877 42183 50514987
Premature delivery 13.39 10.39 3 47951 23660 50533510
Stress 13.31 10.39 92 47862 53701 50503469
Change of bowel habit 13.21 10.39 12 47942 1772 50555398
Bacterial test 13.20 10.39 10 47944 1147 50556023
Sinusitis 13.18 10.39 101 47853 170457 50386713
Respiratory alkalosis 13.16 10.39 14 47940 2505 50554665
Akathisia 13.11 10.39 26 47928 8203 50548967
Knee arthroplasty 13.02 10.39 9 47945 35837 50521333
Cardioactive drug level above therapeutic 12.98 10.39 5 47949 144 50557026
Specific gravity urine decreased 12.72 10.39 8 47946 679 50556491
Peptic ulcer perforation 12.66 10.39 5 47949 154 50557016
Road traffic accident 12.53 10.39 51 47903 24301 50532869
Liver injury 12.43 10.39 4 47950 24802 50532368
Chronic obstructive pulmonary disease 12.42 10.39 90 47864 53345 50503825
Microscopic polyangiitis 12.37 10.39 5 47949 164 50557006
Leukopenia 12.05 10.39 29 47925 67499 50489671
Hip arthroplasty 11.93 10.39 7 47947 30422 50526748
Hyperthermia 11.88 10.39 24 47930 7672 50549498
Irritable bowel syndrome 11.85 10.39 19 47935 51422 50505748
Blood glucose fluctuation 11.83 10.39 17 47937 4129 50553041
Death 11.76 10.39 397 47557 324982 50232188
Clonus 11.74 10.39 17 47937 4158 50553012
Acquired immunodeficiency syndrome 11.66 10.39 4 47950 82 50557088
Diabetes mellitus 11.63 10.39 83 47871 48950 50508220
Pruritus 11.57 10.39 194 47760 283374 50273796
Septic shock 11.48 10.39 23 47931 57152 50500018
Mental impairment 11.39 10.39 31 47923 12013 50545157
Subendocardial ischaemia 11.35 10.39 4 47950 89 50557081
Post-traumatic pain 11.30 10.39 6 47948 370 50556800
Upper-airway cough syndrome 11.27 10.39 25 47929 8525 50548645
Migraine 11.27 10.39 115 47839 75165 50482005
Antidepressant drug level above therapeutic 11.20 10.39 6 47948 377 50556793
Stoma site discomfort 11.11 10.39 4 47950 95 50557075
Dilatation atrial 11.00 10.39 11 47943 1830 50555340
Acne 10.86 10.39 42 47912 19553 50537617
Concussion 10.85 10.39 23 47931 7605 50549565
Respiratory rate decreased 10.77 10.39 14 47940 3094 50554076
Herpes zoster 10.68 10.39 33 47921 70753 50486417
Postmortem blood drug level 10.52 10.39 4 47950 111 50557059
Klebsiella test positive 10.52 10.39 8 47946 923 50556247
Blood albumin decreased 10.52 10.39 32 47922 13204 50543966
Intestinal haemorrhage 10.52 10.39 14 47940 3166 50554004
Drug reaction with eosinophilia and systemic symptoms 10.51 10.39 7 47947 28417 50528753

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 582.22 11.13 772 27725 172889 29373141
Completed suicide 335.12 11.13 423 28074 89823 29456207
Drug abuse 150.27 11.13 273 28224 79610 29466420
Aggression 101.63 11.13 147 28350 35394 29510636
Dysarthria 97.49 11.13 134 28363 30777 29515253
Overdose 85.34 11.13 217 28280 79602 29466428
Intrusive thoughts 81.65 11.13 23 28474 232 29545798
Off label use 72.87 11.13 111 28386 300689 29245341
Substance abuse 70.84 11.13 56 28441 6731 29539299
Logorrhoea 69.58 11.13 37 28460 2251 29543779
Poisoning 68.81 11.13 65 28432 9928 29536102
Suicidal ideation 56.90 11.13 112 28385 34604 29511426
Tachyphrenia 53.63 11.13 25 28472 1144 29544886
Dystonic tremor 50.74 11.13 15 28482 182 29545848
Homicidal ideation 50.35 11.13 31 28466 2493 29543537
Drug dependence 50.32 11.13 80 28417 20901 29525129
Accidental overdose 49.14 11.13 72 28425 17521 29528509
Bradyphrenia 48.84 11.13 37 28460 4177 29541853
Psychotic disorder 47.98 11.13 77 28420 20277 29525753
Suicide attempt 47.61 11.13 103 28394 34007 29512023
Bradykinesia 46.11 11.13 33 28464 3414 29542616
Abnormal behaviour 43.32 11.13 79 28418 23048 29522982
Sedation 39.87 11.13 65 28432 17340 29528690
Pulmonary congestion 39.31 11.13 54 28443 12382 29533648
Restlessness 35.74 11.13 71 28426 22074 29523956
Coordination abnormal 35.68 11.13 39 28458 7075 29538955
Injury 35.59 11.13 65 28432 18981 29527049
Anxiety 32.94 11.13 166 28331 85199 29460831
Insomnia 31.75 11.13 169 28328 88592 29457438
Anger 31.03 11.13 45 28452 10845 29535185
Loss of libido 30.75 11.13 22 28475 2274 29543756
Depressed level of consciousness 28.21 11.13 89 28408 36853 29509177
Hallucination, auditory 27.86 11.13 40 28457 9553 29536477
Psychotic behaviour 27.37 11.13 13 28484 621 29545409
Restless legs syndrome 26.21 11.13 33 28464 6951 29539079
Drug withdrawal syndrome 25.88 11.13 55 28442 17929 29528101
Crystalluria 25.86 11.13 11 28486 404 29545626
Paranoia 25.54 11.13 39 28458 9838 29536192
Irritability 25.49 11.13 62 28435 22090 29523940
Drug interaction 25.32 11.13 296 28201 197089 29348941
Mood swings 25.23 11.13 33 28464 7218 29538812
Respiratory depression 25.07 11.13 46 28451 13477 29532553
Febrile neutropenia 24.65 11.13 44 28453 112196 29433834
Drug ineffective 24.52 11.13 228 28269 362942 29183088
Emotional distress 22.96 11.13 45 28452 13850 29532180
Mesothelioma 22.64 11.13 10 28487 403 29545627
Behaviour disorder 22.03 11.13 22 28475 3594 29542436
Congestive hepatopathy 21.99 11.13 16 28481 1698 29544332
Interstitial lung disease 20.99 11.13 15 28482 57703 29488327
Drug level below therapeutic 20.70 11.13 23 28474 4248 29541782
Mental disorder 20.37 11.13 41 28456 12864 29533166
Depression 20.26 11.13 146 28351 85001 29461029
Homicide 20.06 11.13 12 28485 916 29545114
Osmolar gap abnormal 20.03 11.13 5 28492 30 29546000
Agitation 19.93 11.13 100 28397 51204 29494826
Miosis 19.83 11.13 31 28466 7978 29538052
Accidental poisoning 19.77 11.13 10 28487 548 29545482
Emotional disorder 19.63 11.13 24 28473 4907 29541123
Drug abuser 19.22 11.13 21 28476 3806 29542224
Needle fatigue 19.09 11.13 10 28487 590 29545440
Somnambulism 18.88 11.13 18 28479 2780 29543250
Antasthmatic drug level 18.78 11.13 5 28492 40 29545990
Analgesic drug level 18.78 11.13 5 28492 40 29545990
General physical health deterioration 18.63 11.13 45 28452 102812 29443218
Obsessive-compulsive disorder 17.78 11.13 22 28475 4554 29541476
Gait spastic 17.77 11.13 10 28487 680 29545350
Cardiac asthma 17.63 11.13 7 28490 215 29545815
Drug screen positive 17.62 11.13 20 28477 3781 29542249
Personality change 17.54 11.13 22 28475 4616 29541414
Somnolence 17.36 11.13 152 28345 93803 29452227
Relapsing-remitting multiple sclerosis 17.22 11.13 10 28487 722 29545308
Treatment failure 17.22 11.13 7 28490 36932 29509098
Patient uncooperative 17.12 11.13 8 28489 368 29545662
Memory impairment 17.03 11.13 75 28422 36395 29509635
Conduction disorder 16.71 11.13 14 28483 1826 29544204
Depersonalisation/derealisation disorder 16.56 11.13 9 28488 572 29545458
Blood disorder 16.41 11.13 17 28480 2900 29543130
Feelings of worthlessness 16.38 11.13 7 28490 260 29545770
Contraindication to medical treatment 15.76 11.13 8 28489 442 29545588
Sexually transmitted disease 15.75 11.13 4 28493 26 29546004
Hypertonic bladder 15.16 11.13 12 28485 1444 29544586
Lethargy 15.12 11.13 74 28423 37506 29508524
Accidental death 15.00 11.13 14 28483 2104 29543926
Confusional state 14.72 11.13 188 28309 127689 29418341
Hepatic function abnormal 14.54 11.13 10 28487 39249 29506781
Nervousness 14.48 11.13 33 28464 11273 29534757
Pulmonary oedema 14.33 11.13 80 28417 42655 29503375
Joint swelling 14.32 11.13 16 28481 49614 29496416
Gait disturbance 14.25 11.13 120 28377 73229 29472801
Victim of crime 14.15 11.13 7 28490 366 29545664
Thinking abnormal 14.00 11.13 21 28476 5215 29540815
Tangentiality 13.91 11.13 5 28492 116 29545914
Vestibular disorder 13.89 11.13 10 28487 1044 29544986
Sexually inappropriate behaviour 13.65 11.13 7 28490 395 29545635
Exposure via ingestion 13.65 11.13 13 28484 2005 29544025
Renal impairment 13.63 11.13 37 28460 81296 29464734
Fear 13.59 11.13 29 28468 9475 29536555
Unresponsive to stimuli 13.55 11.13 54 28443 25072 29520958
Product use in unapproved indication 13.48 11.13 41 28456 86834 29459196
Foetal exposure during pregnancy 13.40 11.13 8 28489 33859 29512171
Amnesia 13.30 11.13 50 28447 22593 29523437
Cerebral arteriovenous malformation haemorrhagic 13.14 11.13 4 28493 54 29545976
Withdrawal syndrome 12.89 11.13 31 28466 10961 29535069
Pyrexia 12.67 11.13 198 28299 287424 29258606
Acute kidney injury 12.58 11.13 180 28317 265087 29280943
Breast cancer male 12.54 11.13 6 28491 291 29545739
Dysprosody 12.48 11.13 3 28494 15 29546015
Physical disability 12.34 11.13 10 28487 1244 29544786
Alcohol poisoning 12.24 11.13 15 28482 3074 29542956
Cardiomegaly 12.22 11.13 35 28462 13741 29532289
Borderline personality disorder 11.77 11.13 6 28491 334 29545696
Cytomegalovirus infection 11.49 11.13 4 28493 23211 29522819
Gun shot wound 11.42 11.13 9 28488 1076 29544954
Ventricular hypertrophy 11.25 11.13 17 28480 4247 29541783
Neck injury 11.19 11.13 9 28488 1108 29544922

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 850.16 10.17 1364 60712 362149 64074507
Completed suicide 742.73 10.17 993 61083 223421 64213235
Temperature regulation disorder 240.86 10.17 105 61971 4106 64432550
Overdose 227.20 10.17 485 61591 159081 64277575
Drug abuse 204.34 10.17 416 61660 131958 64304698
Coeliac disease 203.64 10.17 112 61964 7300 64429356
Food allergy 171.10 10.17 102 61974 7749 64428907
Poisoning 140.73 10.17 137 61939 21742 64414914
Off label use 122.81 10.17 267 61809 632539 63804117
Immunodeficiency 115.18 10.17 107 61969 16017 64420639
Substance abuse 113.14 10.17 84 61992 9208 64427448
Bursitis 108.27 10.17 118 61958 21367 64415289
Accidental overdose 108.18 10.17 147 61929 33410 64403246
Respiratory arrest 95.64 10.17 178 61898 52807 64383849
Aggression 86.82 10.17 158 61918 46074 64390582
Drug ineffective 86.22 10.17 467 61609 839780 63596876
Myocardial depression 82.07 10.17 27 62049 476 64436180
Synovitis 75.69 10.17 5 62071 99085 64337571
Dysarthria 73.62 10.17 171 61905 59235 64377421
Death 73.49 10.17 748 61328 481957 63954699
Respiratory depression 72.99 10.17 101 61975 23342 64413314
Decorticate posture 68.17 10.17 21 62055 296 64436360
Fluid retention 67.84 10.17 166 61910 59440 64377216
Intrusive thoughts 65.15 10.17 21 62055 346 64436310
Maternal exposure during pregnancy 64.78 10.17 8 62068 95876 64340780
Drug intolerance 62.99 10.17 53 62023 187939 64248717
Hyperhidrosis 62.48 10.17 262 61814 124658 64311998
Logorrhoea 61.67 10.17 42 62034 4017 64432639
Abnormal behaviour 58.23 10.17 111 61965 33511 64403145
Suicidal ideation 58.15 10.17 168 61908 66374 64370282
Rash erythematous 58.08 10.17 138 61938 48495 64388161
Homicidal ideation 57.48 10.17 37 62039 3220 64433436
Pulmonary congestion 57.25 10.17 91 61985 23789 64412867
Cardiac arrest 53.65 10.17 291 61785 153773 64282883
Cardio-respiratory arrest 52.85 10.17 211 61865 98182 64338474
Dystonic tremor 50.76 10.17 15 62061 182 64436474
Hand deformity 48.43 10.17 3 62073 62768 64373888
Drug dependence 48.15 10.17 102 61974 33210 64403446
Tachyphrenia 47.85 10.17 27 62049 1849 64434807
Asthma 45.49 10.17 197 61879 95028 64341628
Insomnia 45.41 10.17 336 61740 197500 64239156
Arthropathy 44.46 10.17 31 62045 120936 64315720
Infusion related reaction 44.19 10.17 56 62020 164411 64272245
Miosis 44.09 10.17 59 62017 13207 64423449
Suicide attempt 43.67 10.17 159 61917 70848 64365808
Libido increased 43.60 10.17 25 62051 1765 64434891
Irritability 43.58 10.17 104 61972 36642 64400014
Coma scale abnormal 43.23 10.17 45 62031 7729 64428927
Arthralgia 42.33 10.17 251 61825 442009 63994647
Homicide 41.90 10.17 21 62055 1130 64435526
Interstitial lung disease 40.14 10.17 22 62054 97710 64338946
Victim of sexual abuse 40.07 10.17 15 62061 392 64436264
Discomfort 39.86 10.17 14 62062 80864 64355792
Hostility 38.77 10.17 25 62051 2182 64434474
Sternal fracture 38.36 10.17 25 62051 2222 64434434
Soft tissue injury 38.32 10.17 22 62054 1557 64435099
Mental disorder 38.25 10.17 81 61995 26364 64410292
Peripheral swelling 38.15 10.17 91 61985 209062 64227594
Psychotic disorder 37.96 10.17 95 61981 34483 64402173
Anxiety 37.68 10.17 328 61748 202321 64234335
Mood swings 37.06 10.17 63 62013 17405 64419251
Post-traumatic neck syndrome 37.04 10.17 23 62053 1879 64434777
Bradykinesia 36.53 10.17 38 62038 6522 64430134
Intentional overdose 36.23 10.17 177 61899 89767 64346889
General physical health deterioration 34.90 10.17 92 61984 204333 64232323
Depression 34.77 10.17 298 61778 182993 64253663
Back pain 33.87 10.17 379 61697 249792 64186864
Rash 33.68 10.17 281 61795 458268 63978388
Restlessness 33.36 10.17 99 61977 39686 64396970
Bradyphrenia 33.06 10.17 43 62033 9363 64427293
Somnolence 32.99 10.17 320 61756 203325 64233331
Memory impairment 32.66 10.17 166 61910 85516 64351140
Drug withdrawal syndrome 32.30 10.17 84 61992 31207 64405449
Swelling 32.26 10.17 66 62010 160152 64276504
Kyphosis 32.24 10.17 23 62053 2370 64434286
Sedation 31.80 10.17 100 61976 41362 64395294
Impaired reasoning 31.68 10.17 9 62067 94 64436562
Febrile neutropenia 31.62 10.17 85 61991 187572 64249084
Drug abuser 31.19 10.17 33 62043 5775 64430881
Depressed level of consciousness 30.50 10.17 157 61919 81279 64355377
Coordination abnormal 30.47 10.17 53 62023 14911 64421745
Treatment failure 30.11 10.17 41 62035 116775 64319881
Loss of libido 29.87 10.17 22 62054 2382 64434274
Upper respiratory tract infection 29.86 10.17 144 61932 72641 64364015
Exposure during pregnancy 29.76 10.17 19 62057 77656 64359000
Accidental death 29.10 10.17 26 62050 3699 64432957
Constipation 29.05 10.17 343 61733 228994 64207662
Judgement impaired 28.88 10.17 16 62060 1057 64435599
Amblyopia 28.59 10.17 10 62066 214 64436442
Acute kidney injury 27.93 10.17 287 61789 448953 63987703
Poisoning deliberate 27.84 10.17 48 62028 13410 64423246
Unresponsive to stimuli 27.80 10.17 109 61967 50284 64386372
Hepatocellular injury 27.73 10.17 5 62071 45230 64391426
Joint swelling 27.67 10.17 110 61966 215272 64221384
Personality disorder 27.52 10.17 28 62048 4683 64431973
Pericarditis 27.27 10.17 13 62063 62503 64374153
Toxicologic test abnormal 26.91 10.17 16 62060 1209 64435447
Rectal prolapse 26.56 10.17 18 62058 1708 64434948
Venous pressure jugular increased 26.46 10.17 16 62060 1247 64435409
Drug screen positive 26.34 10.17 30 62046 5699 64430957
Transplant dysfunction 25.68 10.17 32 62044 6676 64429980
Abdominal discomfort 25.44 10.17 90 61986 182232 64254424
Cytomegalovirus infection 25.37 10.17 3 62073 37196 64399460
Poor quality sleep 25.07 10.17 56 62020 18895 64417761
Thiopurine methyltransferase decreased 25.02 10.17 10 62066 313 64436343
Thrombocytopenia 24.11 10.17 122 61954 223679 64212977
Intentional product use issue 24.05 10.17 34 62042 95330 64341326
Paranoia 23.55 10.17 50 62026 16302 64420354
Rib fracture 23.26 10.17 63 62013 23975 64412681
Glossodynia 23.21 10.17 17 62059 64679 64371977
Gait spastic 23.19 10.17 13 62063 879 64435777
Withdrawal syndrome 23.17 10.17 62 62014 23430 64413226
Exposure via ingestion 23.10 10.17 26 62050 4876 64431780
Apnoea 22.65 10.17 38 62038 10384 64426272
Neutropenia 22.34 10.17 137 61939 239487 64197169
Pyrexia 22.29 10.17 391 61685 558253 63878403
Nasopharyngitis 22.21 10.17 105 61971 195968 64240688
Somnambulism 22.09 10.17 26 62050 5115 64431541
Infected dermal cyst 21.84 10.17 12 62064 780 64435876
Psychotic behaviour 21.46 10.17 13 62063 1016 64435640
Hypothermia 21.21 10.17 54 62022 19802 64416854
Ovarian cyst 21.11 10.17 38 62038 10980 64425676
Urticaria 21.03 10.17 72 62004 147245 64289411
Urine oxalate increased 20.92 10.17 8 62068 222 64436434
Restless legs syndrome 20.90 10.17 49 62027 17067 64419589
Arteriosclerosis coronary artery 20.67 10.17 46 62030 15483 64421173
Wound 20.57 10.17 26 62050 76451 64360205
Myelocyte percentage increased 20.24 10.17 8 62068 243 64436413
Bruxism 20.19 10.17 21 62055 3603 64433053
Band neutrophil percentage increased 19.71 10.17 9 62067 393 64436263
Depressed mood 19.69 10.17 85 61991 40927 64395729
Pulmonary oedema 19.39 10.17 136 61940 78538 64358118
Needle fatigue 19.29 10.17 10 62066 578 64436078
Systemic lupus erythematosus 19.24 10.17 28 62048 77584 64359072
Victim of crime 19.19 10.17 9 62067 418 64436238
Antasthmatic drug level 18.79 10.17 5 62071 40 64436616
Crystalluria 18.55 10.17 11 62065 827 64435829
Analgesic drug level 18.37 10.17 5 62071 44 64436612
C-reactive protein increased 18.34 10.17 40 62036 94869 64341787
Retinal depigmentation 18.32 10.17 8 62068 314 64436342
Behaviour disorder 18.24 10.17 22 62054 4440 64432216
COVID-19 17.67 10.17 22 62054 65118 64371538
Septic shock 17.57 10.17 48 62028 105389 64331267
Blister 17.46 10.17 32 62044 80935 64355721
Dystrophic calcification 17.44 10.17 6 62070 122 64436534
Alcohol poisoning 17.43 10.17 21 62055 4234 64432422
Drug resistance 17.42 10.17 6 62070 35096 64401560
Amnesia 17.34 10.17 92 61984 48177 64388479
Pruritus 17.23 10.17 205 61871 312195 64124461
Hepatic function abnormal 17.15 10.17 22 62054 64291 64372365
Cardiomegaly 17.14 10.17 56 62020 23628 64413028
Folliculitis 17.04 10.17 4 62072 30073 64406583
Congestive hepatopathy 16.92 10.17 20 62056 3953 64432703
Rectal polyp 16.52 10.17 12 62064 1272 64435384
Lethargy 16.46 10.17 123 61953 72471 64364185
Tremor 16.30 10.17 216 61860 148014 64288642
Thinking abnormal 16.25 10.17 35 62041 11521 64425135
Loss of consciousness 16.24 10.17 216 61860 148149 64288507
Therapeutic product effect decreased 16.04 10.17 57 62019 115294 64321362
Product use in unapproved indication 15.93 10.17 102 61974 176516 64260140
Cholestasis 15.83 10.17 12 62064 44860 64391796
Dilatation atrial 15.75 10.17 18 62058 3432 64433224
Relapsing-remitting multiple sclerosis 15.74 10.17 11 62065 1097 64435559
Osmolar gap abnormal 15.59 10.17 5 62071 81 64436575
Band neutrophil count increased 15.56 10.17 9 62067 646 64436010
Infection 15.56 10.17 109 61967 184771 64251885
Nightmare 15.52 10.17 50 62026 20943 64415713
Delusion 15.26 10.17 45 62031 17969 64418687
Oesophagitis ulcerative 15.21 10.17 10 62066 902 64435754
Accidental poisoning 15.19 10.17 12 62064 1441 64435215
Therapeutic product effect incomplete 15.16 10.17 50 62026 103432 64333224
Ventricular hypokinesia 15.15 10.17 27 62049 7742 64428914
Pneumocystis jirovecii pneumonia 15.02 10.17 4 62072 27630 64409026
Bundle branch block left 14.82 10.17 31 62045 10003 64426653
Stomatitis 14.69 10.17 55 62021 109550 64327106
Panic attack 14.68 10.17 49 62027 20904 64415752
Postmortem blood drug level increased 14.31 10.17 9 62067 752 64435904
Breast cancer male 14.25 10.17 6 62070 215 64436441
Duodenal ulcer 14.13 10.17 38 62038 14397 64422259
Patient uncooperative 14.03 10.17 8 62068 559 64436097
Mental impairment 14.02 10.17 41 62035 16302 64420354
Herpes zoster 13.99 10.17 35 62041 79152 64357504
Duodenal ulcer perforation 13.92 10.17 8 62068 34617 64402039
Myelosuppression 13.84 10.17 3 62073 23827 64412829
Arteriosclerosis 13.78 10.17 40 62036 15837 64420819
Diarrhoea 13.66 10.17 563 61513 722141 63714515
Mobility decreased 13.62 10.17 40 62036 85800 64350856
Accident 13.62 10.17 24 62052 6822 64429834
Agitation 13.39 10.17 137 61939 88230 64348426
Sensitisation 13.36 10.17 12 62064 1719 64434937
Sinusitis 13.30 10.17 84 61992 145844 64290812
Emotional disorder 13.17 10.17 34 62042 12573 64424083
Emotional distress 13.15 10.17 69 62007 35969 64400687
Analgesic drug level above therapeutic 13.15 10.17 7 62069 427 64436229
Cardiac asthma 13.14 10.17 6 62070 262 64436394
Anger 13.03 10.17 39 62037 15702 64420954
Opiates positive 12.95 10.17 9 62067 889 64435767
Anaemia 12.94 10.17 272 61804 378408 64058248
Fibrinolysis 12.88 10.17 4 62072 58 64436598
Condition aggravated 12.87 10.17 267 61809 372159 64064497
Tangentiality 12.77 10.17 5 62071 148 64436508
Gastrointestinal disorder 12.69 10.17 44 62032 89665 64346991
Bacterial test 12.69 10.17 10 62066 1197 64435459
Chronic obstructive pulmonary disease 12.67 10.17 114 61962 70934 64365722
Sexually inappropriate behaviour 12.66 10.17 7 62069 461 64436195
Dysprosody 12.48 10.17 3 62073 15 64436641
Upper respiratory tract congestion 12.43 10.17 13 62063 2245 64434411
Pancytopenia 12.29 10.17 84 61992 143225 64293431
Injury 12.20 10.17 94 61982 55898 64380758
Cardiac failure 12.16 10.17 76 62000 132297 64304359
Suspected counterfeit product 12.04 10.17 7 62069 507 64436149
Myelocyte count increased 11.95 10.17 8 62068 744 64435912
Liver injury 11.91 10.17 7 62069 29925 64406731
Mass 11.85 10.17 37 62039 15239 64421417
Mesothelioma 11.75 10.17 6 62070 336 64436320
Specific gravity urine decreased 11.65 10.17 8 62068 775 64435881
Blood pressure fluctuation 11.64 10.17 20 62056 51851 64384805
Change of bowel habit 11.60 10.17 13 62063 2425 64434231
Mucosal inflammation 11.58 10.17 27 62049 62557 64374099
Hypovolaemia 11.55 10.17 37 62039 15449 64421207
Neurotoxicity 11.49 10.17 6 62070 27398 64409258
Psoriatic arthropathy 11.34 10.17 15 62061 43266 64393390
Hyperlipidaemia 11.32 10.17 48 62028 22928 64413728
Hospitalisation 11.25 10.17 36 62040 75171 64361485
Confusional state 11.25 10.17 330 61746 260814 64175842
Injection site erythema 11.22 10.17 33 62043 70767 64365889
Cyclothymic disorder 11.18 10.17 5 62071 208 64436448
Transaminases increased 11.14 10.17 16 62060 44578 64392078
Drug eruption 11.12 10.17 11 62065 36125 64400531
Concussion 11.11 10.17 24 62052 7914 64428742
Conduction disorder 11.11 10.17 14 62062 2954 64433702
Hepatic steatosis 11.06 10.17 59 62017 30948 64405708
Hypertonic bladder 11.05 10.17 15 62061 3403 64433253
Akathisia 10.97 10.17 30 62046 11480 64425176
Intentional product misuse 10.91 10.17 112 61964 72183 64364473
Ill-defined disorder 10.81 10.17 16 62060 44036 64392620
Coronary artery disease 10.79 10.17 97 61979 60336 64376320
Muscle injury 10.78 10.17 6 62070 26431 64410225
Injection site pain 10.74 10.17 63 62013 111345 64325311
Musculoskeletal stiffness 10.67 10.17 72 62004 123134 64313522
Lip swelling 10.67 10.17 9 62067 31898 64404758
Ventricular hypertrophy 10.65 10.17 21 62055 6495 64430161
Gamma-glutamyltransferase increased 10.61 10.17 19 62057 48491 64388165
Respiratory rate decreased 10.60 10.17 17 62059 4474 64432182
Wrong technique in product usage process 10.51 10.17 30 62046 64944 64371712
Mania 10.46 10.17 37 62039 16249 64420407
Cardioactive drug level above therapeutic 10.41 10.17 5 62071 245 64436411
Shock 10.28 10.17 13 62063 38227 64398429
Subendocardial ischaemia 10.26 10.17 4 62072 117 64436539
Urine odour abnormal 10.21 10.17 18 62058 5118 64431538
Alopecia 10.20 10.17 106 61970 165584 64271072
Feeling abnormal 10.19 10.17 183 61893 133419 64303237

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CD07 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Sleep automatism contraindication 247962006
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Memory impairment contraindication 386807006
Chronic lung disease contraindication 413839001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.07 acidic
pKa2 1.46 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK

External reference:

IDSource
4017894 VUID
N0000146246 NUI
D00370 KEGG_DRUG
4017894 VANDF
C0039468 UMLSCUI
CHEBI:9435 CHEBI
CHEMBL967 ChEMBL_ID
DB00231 DRUGBANK_ID
D013693 MESH_DESCRIPTOR_UI
5391 PUBCHEM_CID
7300 IUPHAR_LIGAND_ID
2753 INN_ID
CHB1QD2QSS UNII
10355 RXNORM
2322 MMSL
5544 MMSL
d00384 MMSL
001450 NDDF
387300007 SNOMEDCT_US
54705000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2076 CAPSULE 15 mg ORAL ANDA 19 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2077 CAPSULE 30 mg ORAL ANDA 19 sections
RESTORIL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9914 CAPSULE 22.50 mg ORAL NDA 26 sections
RESTORIL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9915 CAPSULE 7.50 mg ORAL NDA 26 sections
RESTORIL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9916 CAPSULE 15 mg ORAL NDA 26 sections
RESTORIL HUMAN PRESCRIPTION DRUG LABEL 1 0406-9917 CAPSULE 30 mg ORAL NDA 26 sections
TEMAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 0406-9959 CAPSULE 22.50 mg ORAL NDA 26 sections
TEMAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 0406-9960 CAPSULE 7.50 mg ORAL NDA 26 sections
TEMAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 0406-9961 CAPSULE 15 mg ORAL NDA 26 sections
TEMAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 0406-9962 CAPSULE 30 mg ORAL NDA 26 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7808 CAPSULE 15 mg ORAL ANDA 27 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7809 CAPSULE 30 mg ORAL ANDA 27 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 0904-6436 CAPSULE 7.50 mg ORAL ANDA 24 sections
TEMAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-214 CAPSULE 15 mg ORAL ANDA 14 sections
temazepam Human Prescription Drug Label 1 17856-0148 CAPSULE 15 mg ORAL ANDA 23 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 21695-282 CAPSULE 15 mg ORAL ANDA 24 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 21695-283 CAPSULE 30 mg ORAL ANDA 24 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 33261-101 CAPSULE 15 mg ORAL ANDA 23 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 33261-102 CAPSULE 30 mg ORAL ANDA 23 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 33358-332 CAPSULE 15 mg ORAL ANDA 18 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 35356-663 CAPSULE 30 mg ORAL ANDA 23 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 35356-663 CAPSULE 30 mg ORAL ANDA 23 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 35356-664 CAPSULE 15 mg ORAL ANDA 23 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 35356-664 CAPSULE 15 mg ORAL ANDA 23 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 35356-821 CAPSULE 22.50 mg ORAL ANDA 23 sections
temazepam HUMAN PRESCRIPTION DRUG LABEL 1 35356-821 CAPSULE 22.50 mg ORAL ANDA 23 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 40032-120 CAPSULE 7.50 mg ORAL ANDA 17 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 40032-121 CAPSULE 15 mg ORAL ANDA 17 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 40032-122 CAPSULE 22.50 mg ORAL ANDA 17 sections
Temazepam HUMAN PRESCRIPTION DRUG LABEL 1 40032-123 CAPSULE 30 mg ORAL ANDA 17 sections