Stem definition | Drug id | CAS RN |
---|---|---|
diazepam derivatives | 2585 | 846-50-4 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.60 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.83 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 91 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 27, 1981 | FDA | MALLINCKRODT INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 388.87 | 10.39 | 548 | 47406 | 131341 | 50425829 |
Toxicity to various agents | 358.70 | 10.39 | 686 | 47268 | 211813 | 50345357 |
Temperature regulation disorder | 235.55 | 10.39 | 103 | 47851 | 4124 | 50553046 |
Coeliac disease | 188.74 | 10.39 | 112 | 47842 | 8573 | 50548597 |
Overdose | 176.48 | 10.39 | 329 | 47625 | 99398 | 50457772 |
Food allergy | 174.39 | 10.39 | 104 | 47850 | 8033 | 50549137 |
Immunodeficiency | 124.36 | 10.39 | 107 | 47847 | 14721 | 50542449 |
Bursitis | 105.17 | 10.39 | 117 | 47837 | 22018 | 50535152 |
Hyperhidrosis | 102.25 | 10.39 | 247 | 47707 | 89179 | 50467991 |
Drug ineffective | 99.69 | 10.39 | 420 | 47534 | 818913 | 49738257 |
Maternal exposure during pregnancy | 99.64 | 10.39 | 16 | 47938 | 159762 | 50397408 |
Respiratory arrest | 99.18 | 10.39 | 132 | 47822 | 29877 | 50527293 |
Synovitis | 96.73 | 10.39 | 5 | 47949 | 123860 | 50433310 |
Drug intolerance | 86.70 | 10.39 | 50 | 47904 | 219054 | 50338116 |
Hand deformity | 81.67 | 10.39 | 3 | 47951 | 100196 | 50456974 |
Myocardial depression | 81.30 | 10.39 | 26 | 47928 | 424 | 50556746 |
Rash erythematous | 81.26 | 10.39 | 130 | 47824 | 34722 | 50522448 |
Off label use | 79.56 | 10.39 | 211 | 47743 | 474215 | 50082955 |
Fluid retention | 76.00 | 10.39 | 156 | 47798 | 50493 | 50506677 |
Decorticate posture | 69.43 | 10.39 | 21 | 47933 | 282 | 50556888 |
Arthropathy | 66.89 | 10.39 | 33 | 47921 | 157873 | 50399297 |
Poisoning | 63.03 | 10.39 | 68 | 47886 | 12361 | 50544809 |
Cardiac arrest | 62.67 | 10.39 | 198 | 47756 | 83453 | 50473717 |
Glossodynia | 60.94 | 10.39 | 17 | 47937 | 115552 | 50441618 |
Constipation | 59.52 | 10.39 | 339 | 47615 | 185369 | 50371801 |
Wound | 58.77 | 10.39 | 14 | 47940 | 105780 | 50451390 |
Systemic lupus erythematosus | 58.63 | 10.39 | 30 | 47924 | 140592 | 50416578 |
Accidental overdose | 58.60 | 10.39 | 82 | 47872 | 19451 | 50537719 |
Infusion related reaction | 57.28 | 10.39 | 46 | 47908 | 169511 | 50387659 |
Asthma | 55.02 | 10.39 | 198 | 47756 | 89139 | 50468031 |
Abdominal discomfort | 55.01 | 10.39 | 84 | 47870 | 231557 | 50325613 |
Swelling | 53.55 | 10.39 | 67 | 47887 | 200805 | 50356365 |
Drug abuse | 52.70 | 10.39 | 150 | 47804 | 59696 | 50497474 |
Libido increased | 49.53 | 10.39 | 24 | 47930 | 1219 | 50555951 |
Pericarditis | 48.76 | 10.39 | 8 | 47946 | 78681 | 50478489 |
Exposure during pregnancy | 47.28 | 10.39 | 28 | 47926 | 120987 | 50436183 |
Hostility | 46.78 | 10.39 | 26 | 47928 | 1756 | 50555414 |
Back pain | 46.46 | 10.39 | 362 | 47592 | 219668 | 50337502 |
Substance abuse | 45.65 | 10.39 | 35 | 47919 | 4089 | 50553081 |
Discomfort | 45.35 | 10.39 | 23 | 47931 | 108357 | 50448813 |
Rash | 44.81 | 10.39 | 238 | 47716 | 437233 | 50119937 |
Respiratory depression | 44.63 | 10.39 | 56 | 47898 | 11954 | 50545216 |
Cardio-respiratory arrest | 44.49 | 10.39 | 132 | 47822 | 53760 | 50503410 |
Treatment failure | 44.43 | 10.39 | 39 | 47915 | 137598 | 50419572 |
Upper respiratory tract infection | 42.23 | 10.39 | 148 | 47806 | 65750 | 50491420 |
Arthralgia | 40.43 | 10.39 | 247 | 47707 | 438455 | 50118715 |
Victim of sexual abuse | 40.15 | 10.39 | 16 | 47938 | 505 | 50556665 |
Venous pressure jugular increased | 39.34 | 10.39 | 16 | 47938 | 533 | 50556637 |
Coma scale abnormal | 39.13 | 10.39 | 34 | 47920 | 4737 | 50552433 |
Sternal fracture | 38.81 | 10.39 | 24 | 47930 | 1978 | 50555192 |
Post-traumatic neck syndrome | 37.29 | 10.39 | 23 | 47931 | 1887 | 50555283 |
Soft tissue injury | 37.19 | 10.39 | 21 | 47933 | 1463 | 50555707 |
Anxiety | 35.71 | 10.39 | 289 | 47665 | 177317 | 50379853 |
Insomnia | 35.41 | 10.39 | 285 | 47669 | 174580 | 50382590 |
Joint swelling | 35.26 | 10.39 | 117 | 47837 | 245169 | 50312001 |
Peripheral swelling | 34.84 | 10.39 | 91 | 47863 | 205845 | 50351325 |
Impaired reasoning | 34.07 | 10.39 | 9 | 47945 | 71 | 50557099 |
Hypothermia | 33.91 | 10.39 | 49 | 47905 | 11967 | 50545203 |
Transplant dysfunction | 31.77 | 10.39 | 30 | 47924 | 4654 | 50552516 |
Infected dermal cyst | 31.74 | 10.39 | 13 | 47941 | 441 | 50556729 |
Amblyopia | 31.72 | 10.39 | 11 | 47943 | 233 | 50556937 |
Therapeutic product effect decreased | 29.77 | 10.39 | 52 | 47902 | 135998 | 50421172 |
Alopecia | 29.30 | 10.39 | 126 | 47828 | 244921 | 50312249 |
Kyphosis | 28.80 | 10.39 | 21 | 47933 | 2274 | 50554896 |
Judgement impaired | 28.66 | 10.39 | 13 | 47941 | 568 | 50556602 |
Suicidal ideation | 28.52 | 10.39 | 116 | 47838 | 55269 | 50501901 |
Therapeutic product effect incomplete | 28.25 | 10.39 | 27 | 47927 | 91488 | 50465682 |
Personality disorder | 28.01 | 10.39 | 27 | 47927 | 4297 | 50552873 |
Toxicologic test abnormal | 27.79 | 10.39 | 13 | 47941 | 610 | 50556560 |
Intentional overdose | 27.64 | 10.39 | 125 | 47829 | 62379 | 50494791 |
Drug withdrawal syndrome | 27.27 | 10.39 | 68 | 47886 | 25013 | 50532157 |
Apnoea | 26.71 | 10.39 | 33 | 47921 | 6933 | 50550237 |
Folliculitis | 26.63 | 10.39 | 3 | 47951 | 39222 | 50517948 |
Rectal prolapse | 26.59 | 10.39 | 18 | 47936 | 1731 | 50555439 |
Thiopurine methyltransferase decreased | 25.76 | 10.39 | 10 | 47944 | 294 | 50556876 |
Duodenal ulcer perforation | 25.39 | 10.39 | 6 | 47948 | 45605 | 50511565 |
Somnambulism | 25.07 | 10.39 | 27 | 47927 | 4897 | 50552273 |
Band neutrophil percentage increased | 25.06 | 10.39 | 9 | 47945 | 212 | 50556958 |
Miosis | 24.37 | 10.39 | 30 | 47924 | 6280 | 50550890 |
Contraindicated product administered | 24.29 | 10.39 | 67 | 47887 | 148891 | 50408279 |
Tremor | 24.18 | 10.39 | 189 | 47765 | 114714 | 50442456 |
Somnolence | 23.85 | 10.39 | 238 | 47716 | 154747 | 50402423 |
Depression | 23.54 | 10.39 | 250 | 47704 | 165173 | 50391997 |
Ventricular hypokinesia | 22.36 | 10.39 | 23 | 47931 | 3957 | 50553213 |
Nightmare | 22.31 | 10.39 | 48 | 47906 | 16038 | 50541132 |
Panic attack | 21.62 | 10.39 | 53 | 47901 | 19289 | 50537881 |
Myelocyte percentage increased | 21.60 | 10.39 | 8 | 47946 | 206 | 50556964 |
Oesophagitis ulcerative | 21.40 | 10.39 | 10 | 47944 | 468 | 50556702 |
Nasopharyngitis | 21.37 | 10.39 | 102 | 47852 | 192825 | 50364345 |
Infection | 21.23 | 10.39 | 88 | 47866 | 172866 | 50384304 |
Mental disorder | 21.21 | 10.39 | 57 | 47897 | 21934 | 50535236 |
Poor quality sleep | 21.20 | 10.39 | 48 | 47906 | 16598 | 50540572 |
Band neutrophil count increased | 21.02 | 10.39 | 9 | 47945 | 342 | 50556828 |
Neutropenia | 20.95 | 10.39 | 71 | 47883 | 147894 | 50409276 |
Urine oxalate increased | 20.81 | 10.39 | 8 | 47946 | 229 | 50556941 |
Withdrawal syndrome | 20.52 | 10.39 | 49 | 47905 | 17541 | 50539629 |
Homicide | 20.51 | 10.39 | 9 | 47945 | 363 | 50556807 |
Muscle injury | 20.42 | 10.39 | 5 | 47949 | 37106 | 50520064 |
Bundle branch block left | 19.96 | 10.39 | 27 | 47927 | 6203 | 50550967 |
Rectal polyp | 19.85 | 10.39 | 12 | 47942 | 949 | 50556221 |
Gastrointestinal disorder | 19.85 | 10.39 | 37 | 47917 | 94419 | 50462751 |
Accidental death | 19.74 | 10.39 | 15 | 47939 | 1729 | 50555441 |
Retinal depigmentation | 19.46 | 10.39 | 8 | 47946 | 274 | 50556896 |
Blister | 19.27 | 10.39 | 32 | 47922 | 85386 | 50471784 |
Analgesic drug level above therapeutic | 19.21 | 10.39 | 7 | 47947 | 172 | 50556998 |
Poisoning deliberate | 19.10 | 10.39 | 30 | 47924 | 7882 | 50549288 |
Unresponsive to stimuli | 18.96 | 10.39 | 68 | 47886 | 30541 | 50526629 |
Musculoskeletal stiffness | 18.63 | 10.39 | 61 | 47893 | 128420 | 50428750 |
Interstitial lung disease | 18.47 | 10.39 | 14 | 47940 | 53162 | 50504008 |
Suspected product quality issue | 18.29 | 10.39 | 7 | 47947 | 198 | 50556972 |
Duodenal ulcer | 18.21 | 10.39 | 27 | 47927 | 6748 | 50550422 |
Intentional product use issue | 18.12 | 10.39 | 28 | 47926 | 76890 | 50480280 |
Dystrophic calcification | 18.01 | 10.39 | 6 | 47948 | 112 | 50557058 |
Myelocyte count increased | 17.73 | 10.39 | 8 | 47946 | 345 | 50556825 |
Stomatitis | 17.72 | 10.39 | 44 | 47910 | 101300 | 50455870 |
Hypovolaemia | 17.68 | 10.39 | 32 | 47922 | 9433 | 50547737 |
Ovarian cyst | 17.43 | 10.39 | 40 | 47914 | 13956 | 50543214 |
Depressed mood | 17.31 | 10.39 | 71 | 47883 | 33952 | 50523218 |
Pulmonary congestion | 17.27 | 10.39 | 42 | 47912 | 15205 | 50541965 |
Arteriosclerosis coronary artery | 17.13 | 10.39 | 28 | 47926 | 7608 | 50549562 |
Atrioventricular block first degree | 17.08 | 10.39 | 25 | 47929 | 6176 | 50550994 |
Dehydration | 17.06 | 10.39 | 220 | 47734 | 152229 | 50404941 |
Abnormal behaviour | 17.03 | 10.39 | 49 | 47905 | 19609 | 50537561 |
Injection site erythema | 16.97 | 10.39 | 28 | 47926 | 74908 | 50482262 |
Ill-defined disorder | 15.87 | 10.39 | 17 | 47937 | 54637 | 50502533 |
C-reactive protein increased | 15.85 | 10.39 | 24 | 47930 | 66450 | 50490720 |
Urticaria | 15.84 | 10.39 | 66 | 47888 | 129495 | 50427675 |
Irritability | 15.81 | 10.39 | 61 | 47893 | 28365 | 50528805 |
Rib fracture | 15.78 | 10.39 | 47 | 47907 | 19174 | 50537996 |
Homicidal ideation | 15.75 | 10.39 | 13 | 47941 | 1689 | 50555481 |
Psoriatic arthropathy | 15.56 | 10.39 | 13 | 47941 | 47019 | 50510151 |
Mass | 15.42 | 10.39 | 35 | 47919 | 12122 | 50545048 |
Middle insomnia | 15.39 | 10.39 | 31 | 47923 | 9890 | 50547280 |
Suspected counterfeit product | 15.32 | 10.39 | 7 | 47947 | 311 | 50556859 |
Hepatocellular injury | 15.28 | 10.39 | 3 | 47951 | 25944 | 50531226 |
Cardiac failure congestive | 15.18 | 10.39 | 134 | 47820 | 84248 | 50472922 |
Helicobacter infection | 14.95 | 10.39 | 15 | 47939 | 49687 | 50507483 |
Upper respiratory tract congestion | 14.93 | 10.39 | 13 | 47941 | 1816 | 50555354 |
Transplant rejection | 14.88 | 10.39 | 30 | 47924 | 9579 | 50547591 |
General physical health deterioration | 14.79 | 10.39 | 77 | 47877 | 142357 | 50414813 |
Abortion spontaneous | 14.51 | 10.39 | 11 | 47943 | 41761 | 50515409 |
Sensitisation | 14.46 | 10.39 | 12 | 47942 | 1570 | 50555600 |
Bruxism | 14.32 | 10.39 | 16 | 47938 | 3024 | 50554146 |
Calculus urethral | 14.28 | 10.39 | 3 | 47951 | 7 | 50557163 |
Memory impairment | 14.26 | 10.39 | 126 | 47828 | 79234 | 50477936 |
Monocyte percentage increased | 14.15 | 10.39 | 10 | 47944 | 1031 | 50556139 |
Mood swings | 14.04 | 10.39 | 40 | 47914 | 15914 | 50541256 |
Loss of consciousness | 14.04 | 10.39 | 156 | 47798 | 104197 | 50452973 |
Postmortem blood drug level increased | 13.95 | 10.39 | 8 | 47946 | 574 | 50556596 |
Dysgeusia | 13.74 | 10.39 | 73 | 47881 | 38843 | 50518327 |
Febrile neutropenia | 13.73 | 10.39 | 47 | 47907 | 97620 | 50459550 |
Arteriosclerosis | 13.65 | 10.39 | 28 | 47926 | 9049 | 50548121 |
Amnesia | 13.40 | 10.39 | 77 | 47877 | 42183 | 50514987 |
Premature delivery | 13.39 | 10.39 | 3 | 47951 | 23660 | 50533510 |
Stress | 13.31 | 10.39 | 92 | 47862 | 53701 | 50503469 |
Change of bowel habit | 13.21 | 10.39 | 12 | 47942 | 1772 | 50555398 |
Bacterial test | 13.20 | 10.39 | 10 | 47944 | 1147 | 50556023 |
Sinusitis | 13.18 | 10.39 | 101 | 47853 | 170457 | 50386713 |
Respiratory alkalosis | 13.16 | 10.39 | 14 | 47940 | 2505 | 50554665 |
Akathisia | 13.11 | 10.39 | 26 | 47928 | 8203 | 50548967 |
Knee arthroplasty | 13.02 | 10.39 | 9 | 47945 | 35837 | 50521333 |
Cardioactive drug level above therapeutic | 12.98 | 10.39 | 5 | 47949 | 144 | 50557026 |
Specific gravity urine decreased | 12.72 | 10.39 | 8 | 47946 | 679 | 50556491 |
Peptic ulcer perforation | 12.66 | 10.39 | 5 | 47949 | 154 | 50557016 |
Road traffic accident | 12.53 | 10.39 | 51 | 47903 | 24301 | 50532869 |
Liver injury | 12.43 | 10.39 | 4 | 47950 | 24802 | 50532368 |
Chronic obstructive pulmonary disease | 12.42 | 10.39 | 90 | 47864 | 53345 | 50503825 |
Microscopic polyangiitis | 12.37 | 10.39 | 5 | 47949 | 164 | 50557006 |
Leukopenia | 12.05 | 10.39 | 29 | 47925 | 67499 | 50489671 |
Hip arthroplasty | 11.93 | 10.39 | 7 | 47947 | 30422 | 50526748 |
Hyperthermia | 11.88 | 10.39 | 24 | 47930 | 7672 | 50549498 |
Irritable bowel syndrome | 11.85 | 10.39 | 19 | 47935 | 51422 | 50505748 |
Blood glucose fluctuation | 11.83 | 10.39 | 17 | 47937 | 4129 | 50553041 |
Death | 11.76 | 10.39 | 397 | 47557 | 324982 | 50232188 |
Clonus | 11.74 | 10.39 | 17 | 47937 | 4158 | 50553012 |
Acquired immunodeficiency syndrome | 11.66 | 10.39 | 4 | 47950 | 82 | 50557088 |
Diabetes mellitus | 11.63 | 10.39 | 83 | 47871 | 48950 | 50508220 |
Pruritus | 11.57 | 10.39 | 194 | 47760 | 283374 | 50273796 |
Septic shock | 11.48 | 10.39 | 23 | 47931 | 57152 | 50500018 |
Mental impairment | 11.39 | 10.39 | 31 | 47923 | 12013 | 50545157 |
Subendocardial ischaemia | 11.35 | 10.39 | 4 | 47950 | 89 | 50557081 |
Post-traumatic pain | 11.30 | 10.39 | 6 | 47948 | 370 | 50556800 |
Upper-airway cough syndrome | 11.27 | 10.39 | 25 | 47929 | 8525 | 50548645 |
Migraine | 11.27 | 10.39 | 115 | 47839 | 75165 | 50482005 |
Antidepressant drug level above therapeutic | 11.20 | 10.39 | 6 | 47948 | 377 | 50556793 |
Stoma site discomfort | 11.11 | 10.39 | 4 | 47950 | 95 | 50557075 |
Dilatation atrial | 11.00 | 10.39 | 11 | 47943 | 1830 | 50555340 |
Acne | 10.86 | 10.39 | 42 | 47912 | 19553 | 50537617 |
Concussion | 10.85 | 10.39 | 23 | 47931 | 7605 | 50549565 |
Respiratory rate decreased | 10.77 | 10.39 | 14 | 47940 | 3094 | 50554076 |
Herpes zoster | 10.68 | 10.39 | 33 | 47921 | 70753 | 50486417 |
Postmortem blood drug level | 10.52 | 10.39 | 4 | 47950 | 111 | 50557059 |
Klebsiella test positive | 10.52 | 10.39 | 8 | 47946 | 923 | 50556247 |
Intestinal haemorrhage | 10.52 | 10.39 | 14 | 47940 | 3166 | 50554004 |
Blood albumin decreased | 10.52 | 10.39 | 32 | 47922 | 13204 | 50543966 |
Drug reaction with eosinophilia and systemic symptoms | 10.51 | 10.39 | 7 | 47947 | 28417 | 50528753 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 582.22 | 11.13 | 772 | 27725 | 172889 | 29373141 |
Completed suicide | 335.12 | 11.13 | 423 | 28074 | 89823 | 29456207 |
Drug abuse | 150.27 | 11.13 | 273 | 28224 | 79610 | 29466420 |
Aggression | 101.63 | 11.13 | 147 | 28350 | 35394 | 29510636 |
Dysarthria | 97.49 | 11.13 | 134 | 28363 | 30777 | 29515253 |
Overdose | 85.34 | 11.13 | 217 | 28280 | 79602 | 29466428 |
Intrusive thoughts | 81.65 | 11.13 | 23 | 28474 | 232 | 29545798 |
Off label use | 72.87 | 11.13 | 111 | 28386 | 300689 | 29245341 |
Substance abuse | 70.84 | 11.13 | 56 | 28441 | 6731 | 29539299 |
Logorrhoea | 69.58 | 11.13 | 37 | 28460 | 2251 | 29543779 |
Poisoning | 68.81 | 11.13 | 65 | 28432 | 9928 | 29536102 |
Suicidal ideation | 56.90 | 11.13 | 112 | 28385 | 34604 | 29511426 |
Tachyphrenia | 53.63 | 11.13 | 25 | 28472 | 1144 | 29544886 |
Dystonic tremor | 50.74 | 11.13 | 15 | 28482 | 182 | 29545848 |
Homicidal ideation | 50.35 | 11.13 | 31 | 28466 | 2493 | 29543537 |
Drug dependence | 50.32 | 11.13 | 80 | 28417 | 20901 | 29525129 |
Accidental overdose | 49.14 | 11.13 | 72 | 28425 | 17521 | 29528509 |
Bradyphrenia | 48.84 | 11.13 | 37 | 28460 | 4177 | 29541853 |
Psychotic disorder | 47.98 | 11.13 | 77 | 28420 | 20277 | 29525753 |
Suicide attempt | 47.61 | 11.13 | 103 | 28394 | 34007 | 29512023 |
Bradykinesia | 46.11 | 11.13 | 33 | 28464 | 3414 | 29542616 |
Abnormal behaviour | 43.32 | 11.13 | 79 | 28418 | 23048 | 29522982 |
Sedation | 39.87 | 11.13 | 65 | 28432 | 17340 | 29528690 |
Pulmonary congestion | 39.31 | 11.13 | 54 | 28443 | 12382 | 29533648 |
Restlessness | 35.74 | 11.13 | 71 | 28426 | 22074 | 29523956 |
Coordination abnormal | 35.68 | 11.13 | 39 | 28458 | 7075 | 29538955 |
Injury | 35.59 | 11.13 | 65 | 28432 | 18981 | 29527049 |
Anxiety | 32.94 | 11.13 | 166 | 28331 | 85199 | 29460831 |
Insomnia | 31.75 | 11.13 | 169 | 28328 | 88592 | 29457438 |
Anger | 31.03 | 11.13 | 45 | 28452 | 10845 | 29535185 |
Loss of libido | 30.75 | 11.13 | 22 | 28475 | 2274 | 29543756 |
Depressed level of consciousness | 28.21 | 11.13 | 89 | 28408 | 36853 | 29509177 |
Hallucination, auditory | 27.86 | 11.13 | 40 | 28457 | 9553 | 29536477 |
Psychotic behaviour | 27.37 | 11.13 | 13 | 28484 | 621 | 29545409 |
Restless legs syndrome | 26.21 | 11.13 | 33 | 28464 | 6951 | 29539079 |
Drug withdrawal syndrome | 25.88 | 11.13 | 55 | 28442 | 17929 | 29528101 |
Crystalluria | 25.86 | 11.13 | 11 | 28486 | 404 | 29545626 |
Paranoia | 25.54 | 11.13 | 39 | 28458 | 9838 | 29536192 |
Irritability | 25.49 | 11.13 | 62 | 28435 | 22090 | 29523940 |
Drug interaction | 25.32 | 11.13 | 296 | 28201 | 197089 | 29348941 |
Mood swings | 25.23 | 11.13 | 33 | 28464 | 7218 | 29538812 |
Respiratory depression | 25.07 | 11.13 | 46 | 28451 | 13477 | 29532553 |
Febrile neutropenia | 24.65 | 11.13 | 44 | 28453 | 112196 | 29433834 |
Drug ineffective | 24.52 | 11.13 | 228 | 28269 | 362942 | 29183088 |
Emotional distress | 22.96 | 11.13 | 45 | 28452 | 13850 | 29532180 |
Mesothelioma | 22.64 | 11.13 | 10 | 28487 | 403 | 29545627 |
Behaviour disorder | 22.03 | 11.13 | 22 | 28475 | 3594 | 29542436 |
Congestive hepatopathy | 21.99 | 11.13 | 16 | 28481 | 1698 | 29544332 |
Interstitial lung disease | 20.99 | 11.13 | 15 | 28482 | 57703 | 29488327 |
Drug level below therapeutic | 20.70 | 11.13 | 23 | 28474 | 4248 | 29541782 |
Mental disorder | 20.37 | 11.13 | 41 | 28456 | 12864 | 29533166 |
Depression | 20.26 | 11.13 | 146 | 28351 | 85001 | 29461029 |
Homicide | 20.06 | 11.13 | 12 | 28485 | 916 | 29545114 |
Osmolar gap abnormal | 20.03 | 11.13 | 5 | 28492 | 30 | 29546000 |
Agitation | 19.93 | 11.13 | 100 | 28397 | 51204 | 29494826 |
Miosis | 19.83 | 11.13 | 31 | 28466 | 7978 | 29538052 |
Accidental poisoning | 19.77 | 11.13 | 10 | 28487 | 548 | 29545482 |
Emotional disorder | 19.63 | 11.13 | 24 | 28473 | 4907 | 29541123 |
Drug abuser | 19.22 | 11.13 | 21 | 28476 | 3806 | 29542224 |
Needle fatigue | 19.09 | 11.13 | 10 | 28487 | 590 | 29545440 |
Somnambulism | 18.88 | 11.13 | 18 | 28479 | 2780 | 29543250 |
Antasthmatic drug level | 18.78 | 11.13 | 5 | 28492 | 40 | 29545990 |
Analgesic drug level | 18.78 | 11.13 | 5 | 28492 | 40 | 29545990 |
General physical health deterioration | 18.63 | 11.13 | 45 | 28452 | 102812 | 29443218 |
Obsessive-compulsive disorder | 17.78 | 11.13 | 22 | 28475 | 4554 | 29541476 |
Gait spastic | 17.77 | 11.13 | 10 | 28487 | 680 | 29545350 |
Cardiac asthma | 17.63 | 11.13 | 7 | 28490 | 215 | 29545815 |
Drug screen positive | 17.62 | 11.13 | 20 | 28477 | 3781 | 29542249 |
Personality change | 17.54 | 11.13 | 22 | 28475 | 4616 | 29541414 |
Somnolence | 17.36 | 11.13 | 152 | 28345 | 93803 | 29452227 |
Relapsing-remitting multiple sclerosis | 17.22 | 11.13 | 10 | 28487 | 722 | 29545308 |
Treatment failure | 17.22 | 11.13 | 7 | 28490 | 36932 | 29509098 |
Patient uncooperative | 17.12 | 11.13 | 8 | 28489 | 368 | 29545662 |
Memory impairment | 17.03 | 11.13 | 75 | 28422 | 36395 | 29509635 |
Conduction disorder | 16.71 | 11.13 | 14 | 28483 | 1826 | 29544204 |
Depersonalisation/derealisation disorder | 16.56 | 11.13 | 9 | 28488 | 572 | 29545458 |
Blood disorder | 16.41 | 11.13 | 17 | 28480 | 2900 | 29543130 |
Feelings of worthlessness | 16.38 | 11.13 | 7 | 28490 | 260 | 29545770 |
Contraindication to medical treatment | 15.76 | 11.13 | 8 | 28489 | 442 | 29545588 |
Sexually transmitted disease | 15.75 | 11.13 | 4 | 28493 | 26 | 29546004 |
Hypertonic bladder | 15.16 | 11.13 | 12 | 28485 | 1444 | 29544586 |
Lethargy | 15.12 | 11.13 | 74 | 28423 | 37506 | 29508524 |
Accidental death | 15.00 | 11.13 | 14 | 28483 | 2104 | 29543926 |
Confusional state | 14.72 | 11.13 | 188 | 28309 | 127689 | 29418341 |
Hepatic function abnormal | 14.54 | 11.13 | 10 | 28487 | 39249 | 29506781 |
Nervousness | 14.48 | 11.13 | 33 | 28464 | 11273 | 29534757 |
Pulmonary oedema | 14.33 | 11.13 | 80 | 28417 | 42655 | 29503375 |
Joint swelling | 14.32 | 11.13 | 16 | 28481 | 49614 | 29496416 |
Gait disturbance | 14.25 | 11.13 | 120 | 28377 | 73229 | 29472801 |
Victim of crime | 14.15 | 11.13 | 7 | 28490 | 366 | 29545664 |
Thinking abnormal | 14.00 | 11.13 | 21 | 28476 | 5215 | 29540815 |
Tangentiality | 13.91 | 11.13 | 5 | 28492 | 116 | 29545914 |
Vestibular disorder | 13.89 | 11.13 | 10 | 28487 | 1044 | 29544986 |
Sexually inappropriate behaviour | 13.65 | 11.13 | 7 | 28490 | 395 | 29545635 |
Exposure via ingestion | 13.65 | 11.13 | 13 | 28484 | 2005 | 29544025 |
Renal impairment | 13.63 | 11.13 | 37 | 28460 | 81296 | 29464734 |
Fear | 13.59 | 11.13 | 29 | 28468 | 9475 | 29536555 |
Unresponsive to stimuli | 13.55 | 11.13 | 54 | 28443 | 25072 | 29520958 |
Product use in unapproved indication | 13.48 | 11.13 | 41 | 28456 | 86834 | 29459196 |
Foetal exposure during pregnancy | 13.40 | 11.13 | 8 | 28489 | 33859 | 29512171 |
Amnesia | 13.30 | 11.13 | 50 | 28447 | 22593 | 29523437 |
Cerebral arteriovenous malformation haemorrhagic | 13.14 | 11.13 | 4 | 28493 | 54 | 29545976 |
Withdrawal syndrome | 12.89 | 11.13 | 31 | 28466 | 10961 | 29535069 |
Pyrexia | 12.67 | 11.13 | 198 | 28299 | 287424 | 29258606 |
Acute kidney injury | 12.58 | 11.13 | 180 | 28317 | 265087 | 29280943 |
Breast cancer male | 12.54 | 11.13 | 6 | 28491 | 291 | 29545739 |
Dysprosody | 12.48 | 11.13 | 3 | 28494 | 15 | 29546015 |
Physical disability | 12.34 | 11.13 | 10 | 28487 | 1244 | 29544786 |
Alcohol poisoning | 12.24 | 11.13 | 15 | 28482 | 3074 | 29542956 |
Cardiomegaly | 12.22 | 11.13 | 35 | 28462 | 13741 | 29532289 |
Borderline personality disorder | 11.77 | 11.13 | 6 | 28491 | 334 | 29545696 |
Cytomegalovirus infection | 11.49 | 11.13 | 4 | 28493 | 23211 | 29522819 |
Gun shot wound | 11.42 | 11.13 | 9 | 28488 | 1076 | 29544954 |
Ventricular hypertrophy | 11.25 | 11.13 | 17 | 28480 | 4247 | 29541783 |
Neck injury | 11.19 | 11.13 | 9 | 28488 | 1108 | 29544922 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 850.16 | 10.17 | 1364 | 60712 | 362149 | 64074507 |
Completed suicide | 742.73 | 10.17 | 993 | 61083 | 223421 | 64213235 |
Temperature regulation disorder | 240.86 | 10.17 | 105 | 61971 | 4106 | 64432550 |
Overdose | 227.20 | 10.17 | 485 | 61591 | 159081 | 64277575 |
Drug abuse | 204.34 | 10.17 | 416 | 61660 | 131958 | 64304698 |
Coeliac disease | 203.64 | 10.17 | 112 | 61964 | 7300 | 64429356 |
Food allergy | 171.10 | 10.17 | 102 | 61974 | 7749 | 64428907 |
Poisoning | 140.73 | 10.17 | 137 | 61939 | 21742 | 64414914 |
Off label use | 122.81 | 10.17 | 267 | 61809 | 632539 | 63804117 |
Immunodeficiency | 115.18 | 10.17 | 107 | 61969 | 16017 | 64420639 |
Substance abuse | 113.14 | 10.17 | 84 | 61992 | 9208 | 64427448 |
Bursitis | 108.27 | 10.17 | 118 | 61958 | 21367 | 64415289 |
Accidental overdose | 108.18 | 10.17 | 147 | 61929 | 33410 | 64403246 |
Respiratory arrest | 95.64 | 10.17 | 178 | 61898 | 52807 | 64383849 |
Aggression | 86.82 | 10.17 | 158 | 61918 | 46074 | 64390582 |
Drug ineffective | 86.22 | 10.17 | 467 | 61609 | 839780 | 63596876 |
Myocardial depression | 82.07 | 10.17 | 27 | 62049 | 476 | 64436180 |
Synovitis | 75.69 | 10.17 | 5 | 62071 | 99085 | 64337571 |
Dysarthria | 73.62 | 10.17 | 171 | 61905 | 59235 | 64377421 |
Death | 73.49 | 10.17 | 748 | 61328 | 481957 | 63954699 |
Respiratory depression | 72.99 | 10.17 | 101 | 61975 | 23342 | 64413314 |
Decorticate posture | 68.17 | 10.17 | 21 | 62055 | 296 | 64436360 |
Fluid retention | 67.84 | 10.17 | 166 | 61910 | 59440 | 64377216 |
Intrusive thoughts | 65.15 | 10.17 | 21 | 62055 | 346 | 64436310 |
Maternal exposure during pregnancy | 64.78 | 10.17 | 8 | 62068 | 95876 | 64340780 |
Drug intolerance | 62.99 | 10.17 | 53 | 62023 | 187939 | 64248717 |
Hyperhidrosis | 62.48 | 10.17 | 262 | 61814 | 124658 | 64311998 |
Logorrhoea | 61.67 | 10.17 | 42 | 62034 | 4017 | 64432639 |
Abnormal behaviour | 58.23 | 10.17 | 111 | 61965 | 33511 | 64403145 |
Suicidal ideation | 58.15 | 10.17 | 168 | 61908 | 66374 | 64370282 |
Rash erythematous | 58.08 | 10.17 | 138 | 61938 | 48495 | 64388161 |
Homicidal ideation | 57.48 | 10.17 | 37 | 62039 | 3220 | 64433436 |
Pulmonary congestion | 57.25 | 10.17 | 91 | 61985 | 23789 | 64412867 |
Cardiac arrest | 53.65 | 10.17 | 291 | 61785 | 153773 | 64282883 |
Cardio-respiratory arrest | 52.85 | 10.17 | 211 | 61865 | 98182 | 64338474 |
Dystonic tremor | 50.76 | 10.17 | 15 | 62061 | 182 | 64436474 |
Hand deformity | 48.43 | 10.17 | 3 | 62073 | 62768 | 64373888 |
Drug dependence | 48.15 | 10.17 | 102 | 61974 | 33210 | 64403446 |
Tachyphrenia | 47.85 | 10.17 | 27 | 62049 | 1849 | 64434807 |
Asthma | 45.49 | 10.17 | 197 | 61879 | 95028 | 64341628 |
Insomnia | 45.41 | 10.17 | 336 | 61740 | 197500 | 64239156 |
Arthropathy | 44.46 | 10.17 | 31 | 62045 | 120936 | 64315720 |
Infusion related reaction | 44.19 | 10.17 | 56 | 62020 | 164411 | 64272245 |
Miosis | 44.09 | 10.17 | 59 | 62017 | 13207 | 64423449 |
Suicide attempt | 43.67 | 10.17 | 159 | 61917 | 70848 | 64365808 |
Libido increased | 43.60 | 10.17 | 25 | 62051 | 1765 | 64434891 |
Irritability | 43.58 | 10.17 | 104 | 61972 | 36642 | 64400014 |
Coma scale abnormal | 43.23 | 10.17 | 45 | 62031 | 7729 | 64428927 |
Arthralgia | 42.33 | 10.17 | 251 | 61825 | 442009 | 63994647 |
Homicide | 41.90 | 10.17 | 21 | 62055 | 1130 | 64435526 |
Interstitial lung disease | 40.14 | 10.17 | 22 | 62054 | 97710 | 64338946 |
Victim of sexual abuse | 40.07 | 10.17 | 15 | 62061 | 392 | 64436264 |
Discomfort | 39.86 | 10.17 | 14 | 62062 | 80864 | 64355792 |
Hostility | 38.77 | 10.17 | 25 | 62051 | 2182 | 64434474 |
Sternal fracture | 38.36 | 10.17 | 25 | 62051 | 2222 | 64434434 |
Soft tissue injury | 38.32 | 10.17 | 22 | 62054 | 1557 | 64435099 |
Mental disorder | 38.25 | 10.17 | 81 | 61995 | 26364 | 64410292 |
Peripheral swelling | 38.15 | 10.17 | 91 | 61985 | 209062 | 64227594 |
Psychotic disorder | 37.96 | 10.17 | 95 | 61981 | 34483 | 64402173 |
Anxiety | 37.68 | 10.17 | 328 | 61748 | 202321 | 64234335 |
Mood swings | 37.06 | 10.17 | 63 | 62013 | 17405 | 64419251 |
Post-traumatic neck syndrome | 37.04 | 10.17 | 23 | 62053 | 1879 | 64434777 |
Bradykinesia | 36.53 | 10.17 | 38 | 62038 | 6522 | 64430134 |
Intentional overdose | 36.23 | 10.17 | 177 | 61899 | 89767 | 64346889 |
General physical health deterioration | 34.90 | 10.17 | 92 | 61984 | 204333 | 64232323 |
Depression | 34.77 | 10.17 | 298 | 61778 | 182993 | 64253663 |
Back pain | 33.87 | 10.17 | 379 | 61697 | 249792 | 64186864 |
Rash | 33.68 | 10.17 | 281 | 61795 | 458268 | 63978388 |
Restlessness | 33.36 | 10.17 | 99 | 61977 | 39686 | 64396970 |
Bradyphrenia | 33.06 | 10.17 | 43 | 62033 | 9363 | 64427293 |
Somnolence | 32.99 | 10.17 | 320 | 61756 | 203325 | 64233331 |
Memory impairment | 32.66 | 10.17 | 166 | 61910 | 85516 | 64351140 |
Drug withdrawal syndrome | 32.30 | 10.17 | 84 | 61992 | 31207 | 64405449 |
Swelling | 32.26 | 10.17 | 66 | 62010 | 160152 | 64276504 |
Kyphosis | 32.24 | 10.17 | 23 | 62053 | 2370 | 64434286 |
Sedation | 31.80 | 10.17 | 100 | 61976 | 41362 | 64395294 |
Impaired reasoning | 31.68 | 10.17 | 9 | 62067 | 94 | 64436562 |
Febrile neutropenia | 31.62 | 10.17 | 85 | 61991 | 187572 | 64249084 |
Drug abuser | 31.19 | 10.17 | 33 | 62043 | 5775 | 64430881 |
Depressed level of consciousness | 30.50 | 10.17 | 157 | 61919 | 81279 | 64355377 |
Coordination abnormal | 30.47 | 10.17 | 53 | 62023 | 14911 | 64421745 |
Treatment failure | 30.11 | 10.17 | 41 | 62035 | 116775 | 64319881 |
Loss of libido | 29.87 | 10.17 | 22 | 62054 | 2382 | 64434274 |
Upper respiratory tract infection | 29.86 | 10.17 | 144 | 61932 | 72641 | 64364015 |
Exposure during pregnancy | 29.76 | 10.17 | 19 | 62057 | 77656 | 64359000 |
Accidental death | 29.10 | 10.17 | 26 | 62050 | 3699 | 64432957 |
Constipation | 29.05 | 10.17 | 343 | 61733 | 228994 | 64207662 |
Judgement impaired | 28.88 | 10.17 | 16 | 62060 | 1057 | 64435599 |
Amblyopia | 28.59 | 10.17 | 10 | 62066 | 214 | 64436442 |
Acute kidney injury | 27.93 | 10.17 | 287 | 61789 | 448953 | 63987703 |
Poisoning deliberate | 27.84 | 10.17 | 48 | 62028 | 13410 | 64423246 |
Unresponsive to stimuli | 27.80 | 10.17 | 109 | 61967 | 50284 | 64386372 |
Hepatocellular injury | 27.73 | 10.17 | 5 | 62071 | 45230 | 64391426 |
Joint swelling | 27.67 | 10.17 | 110 | 61966 | 215272 | 64221384 |
Personality disorder | 27.52 | 10.17 | 28 | 62048 | 4683 | 64431973 |
Pericarditis | 27.27 | 10.17 | 13 | 62063 | 62503 | 64374153 |
Toxicologic test abnormal | 26.91 | 10.17 | 16 | 62060 | 1209 | 64435447 |
Rectal prolapse | 26.56 | 10.17 | 18 | 62058 | 1708 | 64434948 |
Venous pressure jugular increased | 26.46 | 10.17 | 16 | 62060 | 1247 | 64435409 |
Drug screen positive | 26.34 | 10.17 | 30 | 62046 | 5699 | 64430957 |
Transplant dysfunction | 25.68 | 10.17 | 32 | 62044 | 6676 | 64429980 |
Abdominal discomfort | 25.44 | 10.17 | 90 | 61986 | 182232 | 64254424 |
Cytomegalovirus infection | 25.37 | 10.17 | 3 | 62073 | 37196 | 64399460 |
Poor quality sleep | 25.07 | 10.17 | 56 | 62020 | 18895 | 64417761 |
Thiopurine methyltransferase decreased | 25.02 | 10.17 | 10 | 62066 | 313 | 64436343 |
Thrombocytopenia | 24.11 | 10.17 | 122 | 61954 | 223679 | 64212977 |
Intentional product use issue | 24.05 | 10.17 | 34 | 62042 | 95330 | 64341326 |
Paranoia | 23.55 | 10.17 | 50 | 62026 | 16302 | 64420354 |
Rib fracture | 23.26 | 10.17 | 63 | 62013 | 23975 | 64412681 |
Glossodynia | 23.21 | 10.17 | 17 | 62059 | 64679 | 64371977 |
Gait spastic | 23.19 | 10.17 | 13 | 62063 | 879 | 64435777 |
Withdrawal syndrome | 23.17 | 10.17 | 62 | 62014 | 23430 | 64413226 |
Exposure via ingestion | 23.10 | 10.17 | 26 | 62050 | 4876 | 64431780 |
Apnoea | 22.65 | 10.17 | 38 | 62038 | 10384 | 64426272 |
Neutropenia | 22.34 | 10.17 | 137 | 61939 | 239487 | 64197169 |
Pyrexia | 22.29 | 10.17 | 391 | 61685 | 558253 | 63878403 |
Nasopharyngitis | 22.21 | 10.17 | 105 | 61971 | 195968 | 64240688 |
Somnambulism | 22.09 | 10.17 | 26 | 62050 | 5115 | 64431541 |
Infected dermal cyst | 21.84 | 10.17 | 12 | 62064 | 780 | 64435876 |
Psychotic behaviour | 21.46 | 10.17 | 13 | 62063 | 1016 | 64435640 |
Hypothermia | 21.21 | 10.17 | 54 | 62022 | 19802 | 64416854 |
Ovarian cyst | 21.11 | 10.17 | 38 | 62038 | 10980 | 64425676 |
Urticaria | 21.03 | 10.17 | 72 | 62004 | 147245 | 64289411 |
Urine oxalate increased | 20.92 | 10.17 | 8 | 62068 | 222 | 64436434 |
Restless legs syndrome | 20.90 | 10.17 | 49 | 62027 | 17067 | 64419589 |
Arteriosclerosis coronary artery | 20.67 | 10.17 | 46 | 62030 | 15483 | 64421173 |
Wound | 20.57 | 10.17 | 26 | 62050 | 76451 | 64360205 |
Myelocyte percentage increased | 20.24 | 10.17 | 8 | 62068 | 243 | 64436413 |
Bruxism | 20.19 | 10.17 | 21 | 62055 | 3603 | 64433053 |
Band neutrophil percentage increased | 19.71 | 10.17 | 9 | 62067 | 393 | 64436263 |
Depressed mood | 19.69 | 10.17 | 85 | 61991 | 40927 | 64395729 |
Pulmonary oedema | 19.39 | 10.17 | 136 | 61940 | 78538 | 64358118 |
Needle fatigue | 19.29 | 10.17 | 10 | 62066 | 578 | 64436078 |
Systemic lupus erythematosus | 19.24 | 10.17 | 28 | 62048 | 77584 | 64359072 |
Victim of crime | 19.19 | 10.17 | 9 | 62067 | 418 | 64436238 |
Antasthmatic drug level | 18.79 | 10.17 | 5 | 62071 | 40 | 64436616 |
Crystalluria | 18.55 | 10.17 | 11 | 62065 | 827 | 64435829 |
Analgesic drug level | 18.37 | 10.17 | 5 | 62071 | 44 | 64436612 |
C-reactive protein increased | 18.34 | 10.17 | 40 | 62036 | 94869 | 64341787 |
Retinal depigmentation | 18.32 | 10.17 | 8 | 62068 | 314 | 64436342 |
Behaviour disorder | 18.24 | 10.17 | 22 | 62054 | 4440 | 64432216 |
COVID-19 | 17.67 | 10.17 | 22 | 62054 | 65118 | 64371538 |
Septic shock | 17.57 | 10.17 | 48 | 62028 | 105389 | 64331267 |
Blister | 17.46 | 10.17 | 32 | 62044 | 80935 | 64355721 |
Dystrophic calcification | 17.44 | 10.17 | 6 | 62070 | 122 | 64436534 |
Alcohol poisoning | 17.43 | 10.17 | 21 | 62055 | 4234 | 64432422 |
Drug resistance | 17.42 | 10.17 | 6 | 62070 | 35096 | 64401560 |
Amnesia | 17.34 | 10.17 | 92 | 61984 | 48177 | 64388479 |
Pruritus | 17.23 | 10.17 | 205 | 61871 | 312195 | 64124461 |
Hepatic function abnormal | 17.15 | 10.17 | 22 | 62054 | 64291 | 64372365 |
Cardiomegaly | 17.14 | 10.17 | 56 | 62020 | 23628 | 64413028 |
Folliculitis | 17.04 | 10.17 | 4 | 62072 | 30073 | 64406583 |
Congestive hepatopathy | 16.92 | 10.17 | 20 | 62056 | 3953 | 64432703 |
Rectal polyp | 16.52 | 10.17 | 12 | 62064 | 1272 | 64435384 |
Lethargy | 16.46 | 10.17 | 123 | 61953 | 72471 | 64364185 |
Tremor | 16.30 | 10.17 | 216 | 61860 | 148014 | 64288642 |
Thinking abnormal | 16.25 | 10.17 | 35 | 62041 | 11521 | 64425135 |
Loss of consciousness | 16.24 | 10.17 | 216 | 61860 | 148149 | 64288507 |
Therapeutic product effect decreased | 16.04 | 10.17 | 57 | 62019 | 115294 | 64321362 |
Product use in unapproved indication | 15.93 | 10.17 | 102 | 61974 | 176516 | 64260140 |
Cholestasis | 15.83 | 10.17 | 12 | 62064 | 44860 | 64391796 |
Dilatation atrial | 15.75 | 10.17 | 18 | 62058 | 3432 | 64433224 |
Relapsing-remitting multiple sclerosis | 15.74 | 10.17 | 11 | 62065 | 1097 | 64435559 |
Osmolar gap abnormal | 15.59 | 10.17 | 5 | 62071 | 81 | 64436575 |
Band neutrophil count increased | 15.56 | 10.17 | 9 | 62067 | 646 | 64436010 |
Infection | 15.56 | 10.17 | 109 | 61967 | 184771 | 64251885 |
Nightmare | 15.52 | 10.17 | 50 | 62026 | 20943 | 64415713 |
Delusion | 15.26 | 10.17 | 45 | 62031 | 17969 | 64418687 |
Oesophagitis ulcerative | 15.21 | 10.17 | 10 | 62066 | 902 | 64435754 |
Accidental poisoning | 15.19 | 10.17 | 12 | 62064 | 1441 | 64435215 |
Therapeutic product effect incomplete | 15.16 | 10.17 | 50 | 62026 | 103432 | 64333224 |
Ventricular hypokinesia | 15.15 | 10.17 | 27 | 62049 | 7742 | 64428914 |
Pneumocystis jirovecii pneumonia | 15.02 | 10.17 | 4 | 62072 | 27630 | 64409026 |
Bundle branch block left | 14.82 | 10.17 | 31 | 62045 | 10003 | 64426653 |
Stomatitis | 14.69 | 10.17 | 55 | 62021 | 109550 | 64327106 |
Panic attack | 14.68 | 10.17 | 49 | 62027 | 20904 | 64415752 |
Postmortem blood drug level increased | 14.31 | 10.17 | 9 | 62067 | 752 | 64435904 |
Breast cancer male | 14.25 | 10.17 | 6 | 62070 | 215 | 64436441 |
Duodenal ulcer | 14.13 | 10.17 | 38 | 62038 | 14397 | 64422259 |
Patient uncooperative | 14.03 | 10.17 | 8 | 62068 | 559 | 64436097 |
Mental impairment | 14.02 | 10.17 | 41 | 62035 | 16302 | 64420354 |
Herpes zoster | 13.99 | 10.17 | 35 | 62041 | 79152 | 64357504 |
Duodenal ulcer perforation | 13.92 | 10.17 | 8 | 62068 | 34617 | 64402039 |
Myelosuppression | 13.84 | 10.17 | 3 | 62073 | 23827 | 64412829 |
Arteriosclerosis | 13.78 | 10.17 | 40 | 62036 | 15837 | 64420819 |
Diarrhoea | 13.66 | 10.17 | 563 | 61513 | 722141 | 63714515 |
Mobility decreased | 13.62 | 10.17 | 40 | 62036 | 85800 | 64350856 |
Accident | 13.62 | 10.17 | 24 | 62052 | 6822 | 64429834 |
Agitation | 13.39 | 10.17 | 137 | 61939 | 88230 | 64348426 |
Sensitisation | 13.36 | 10.17 | 12 | 62064 | 1719 | 64434937 |
Sinusitis | 13.30 | 10.17 | 84 | 61992 | 145844 | 64290812 |
Emotional disorder | 13.17 | 10.17 | 34 | 62042 | 12573 | 64424083 |
Emotional distress | 13.15 | 10.17 | 69 | 62007 | 35969 | 64400687 |
Analgesic drug level above therapeutic | 13.15 | 10.17 | 7 | 62069 | 427 | 64436229 |
Cardiac asthma | 13.14 | 10.17 | 6 | 62070 | 262 | 64436394 |
Anger | 13.03 | 10.17 | 39 | 62037 | 15702 | 64420954 |
Opiates positive | 12.95 | 10.17 | 9 | 62067 | 889 | 64435767 |
Anaemia | 12.94 | 10.17 | 272 | 61804 | 378408 | 64058248 |
Fibrinolysis | 12.88 | 10.17 | 4 | 62072 | 58 | 64436598 |
Condition aggravated | 12.87 | 10.17 | 267 | 61809 | 372159 | 64064497 |
Tangentiality | 12.77 | 10.17 | 5 | 62071 | 148 | 64436508 |
Gastrointestinal disorder | 12.69 | 10.17 | 44 | 62032 | 89665 | 64346991 |
Bacterial test | 12.69 | 10.17 | 10 | 62066 | 1197 | 64435459 |
Chronic obstructive pulmonary disease | 12.67 | 10.17 | 114 | 61962 | 70934 | 64365722 |
Sexually inappropriate behaviour | 12.66 | 10.17 | 7 | 62069 | 461 | 64436195 |
Dysprosody | 12.48 | 10.17 | 3 | 62073 | 15 | 64436641 |
Upper respiratory tract congestion | 12.43 | 10.17 | 13 | 62063 | 2245 | 64434411 |
Pancytopenia | 12.29 | 10.17 | 84 | 61992 | 143225 | 64293431 |
Injury | 12.20 | 10.17 | 94 | 61982 | 55898 | 64380758 |
Cardiac failure | 12.16 | 10.17 | 76 | 62000 | 132297 | 64304359 |
Suspected counterfeit product | 12.04 | 10.17 | 7 | 62069 | 507 | 64436149 |
Myelocyte count increased | 11.95 | 10.17 | 8 | 62068 | 744 | 64435912 |
Liver injury | 11.91 | 10.17 | 7 | 62069 | 29925 | 64406731 |
Mass | 11.85 | 10.17 | 37 | 62039 | 15239 | 64421417 |
Mesothelioma | 11.75 | 10.17 | 6 | 62070 | 336 | 64436320 |
Specific gravity urine decreased | 11.65 | 10.17 | 8 | 62068 | 775 | 64435881 |
Blood pressure fluctuation | 11.64 | 10.17 | 20 | 62056 | 51851 | 64384805 |
Change of bowel habit | 11.60 | 10.17 | 13 | 62063 | 2425 | 64434231 |
Mucosal inflammation | 11.58 | 10.17 | 27 | 62049 | 62557 | 64374099 |
Hypovolaemia | 11.55 | 10.17 | 37 | 62039 | 15449 | 64421207 |
Neurotoxicity | 11.49 | 10.17 | 6 | 62070 | 27398 | 64409258 |
Psoriatic arthropathy | 11.34 | 10.17 | 15 | 62061 | 43266 | 64393390 |
Hyperlipidaemia | 11.32 | 10.17 | 48 | 62028 | 22928 | 64413728 |
Hospitalisation | 11.25 | 10.17 | 36 | 62040 | 75171 | 64361485 |
Confusional state | 11.25 | 10.17 | 330 | 61746 | 260814 | 64175842 |
Injection site erythema | 11.22 | 10.17 | 33 | 62043 | 70767 | 64365889 |
Cyclothymic disorder | 11.18 | 10.17 | 5 | 62071 | 208 | 64436448 |
Transaminases increased | 11.14 | 10.17 | 16 | 62060 | 44578 | 64392078 |
Drug eruption | 11.12 | 10.17 | 11 | 62065 | 36125 | 64400531 |
Concussion | 11.11 | 10.17 | 24 | 62052 | 7914 | 64428742 |
Conduction disorder | 11.11 | 10.17 | 14 | 62062 | 2954 | 64433702 |
Hepatic steatosis | 11.06 | 10.17 | 59 | 62017 | 30948 | 64405708 |
Hypertonic bladder | 11.05 | 10.17 | 15 | 62061 | 3403 | 64433253 |
Akathisia | 10.97 | 10.17 | 30 | 62046 | 11480 | 64425176 |
Intentional product misuse | 10.91 | 10.17 | 112 | 61964 | 72183 | 64364473 |
Ill-defined disorder | 10.81 | 10.17 | 16 | 62060 | 44036 | 64392620 |
Coronary artery disease | 10.79 | 10.17 | 97 | 61979 | 60336 | 64376320 |
Muscle injury | 10.78 | 10.17 | 6 | 62070 | 26431 | 64410225 |
Injection site pain | 10.74 | 10.17 | 63 | 62013 | 111345 | 64325311 |
Musculoskeletal stiffness | 10.67 | 10.17 | 72 | 62004 | 123134 | 64313522 |
Lip swelling | 10.67 | 10.17 | 9 | 62067 | 31898 | 64404758 |
Ventricular hypertrophy | 10.65 | 10.17 | 21 | 62055 | 6495 | 64430161 |
Gamma-glutamyltransferase increased | 10.61 | 10.17 | 19 | 62057 | 48491 | 64388165 |
Respiratory rate decreased | 10.60 | 10.17 | 17 | 62059 | 4474 | 64432182 |
Wrong technique in product usage process | 10.51 | 10.17 | 30 | 62046 | 64944 | 64371712 |
Mania | 10.46 | 10.17 | 37 | 62039 | 16249 | 64420407 |
Cardioactive drug level above therapeutic | 10.41 | 10.17 | 5 | 62071 | 245 | 64436411 |
Shock | 10.28 | 10.17 | 13 | 62063 | 38227 | 64398429 |
Subendocardial ischaemia | 10.26 | 10.17 | 4 | 62072 | 117 | 64436539 |
Urine odour abnormal | 10.21 | 10.17 | 18 | 62058 | 5118 | 64431538 |
Alopecia | 10.20 | 10.17 | 106 | 61970 | 165584 | 64271072 |
Feeling abnormal | 10.19 | 10.17 | 183 | 61893 | 133419 | 64303237 |
None
Source | Code | Description |
---|---|---|
ATC | N05CD07 | NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Benzodiazepine derivatives |
FDA CS | M0002356 | Benzodiazepines |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018682 | GABA Agents |
MeSH PA | D018757 | GABA Modulators |
MeSH PA | D006993 | Hypnotics and Sedatives |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D014149 | Tranquilizing Agents |
FDA EPC | N0000175694 | Benzodiazepine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Insomnia | indication | 193462001 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcohol intoxication | contraindication | 25702006 | |
Depressive disorder | contraindication | 35489007 | |
Substance abuse | contraindication | 66214007 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hypoalbuminemia | contraindication | 119247004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Sleep automatism | contraindication | 247962006 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
Memory impairment | contraindication | 386807006 | |
Chronic lung disease | contraindication | 413839001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.07 | acidic |
pKa2 | 1.46 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
GABA-A receptor alpha-1/beta-2/gamma-2 | Ion channel | POSITIVE ALLOSTERIC MODULATOR | WOMBAT-PK | CHEMBL | |||||
Nuclear receptor subfamily 1 group I member 3 | Nuclear hormone receptor | WOMBAT-PK |
ID | Source |
---|---|
4017894 | VUID |
N0000146246 | NUI |
D00370 | KEGG_DRUG |
4017894 | VANDF |
C0039468 | UMLSCUI |
CHEBI:9435 | CHEBI |
CHEMBL967 | ChEMBL_ID |
DB00231 | DRUGBANK_ID |
D013693 | MESH_DESCRIPTOR_UI |
5391 | PUBCHEM_CID |
7300 | IUPHAR_LIGAND_ID |
2753 | INN_ID |
CHB1QD2QSS | UNII |
10355 | RXNORM |
2322 | MMSL |
5544 | MMSL |
d00384 | MMSL |
001450 | NDDF |
387300007 | SNOMEDCT_US |
54705000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2076 | CAPSULE | 15 mg | ORAL | ANDA | 19 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2077 | CAPSULE | 30 mg | ORAL | ANDA | 19 sections |
RESTORIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9914 | CAPSULE | 22.50 mg | ORAL | NDA | 26 sections |
RESTORIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9915 | CAPSULE | 7.50 mg | ORAL | NDA | 26 sections |
RESTORIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9916 | CAPSULE | 15 mg | ORAL | NDA | 26 sections |
RESTORIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9917 | CAPSULE | 30 mg | ORAL | NDA | 26 sections |
TEMAZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9959 | CAPSULE | 22.50 mg | ORAL | NDA | 26 sections |
TEMAZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9960 | CAPSULE | 7.50 mg | ORAL | NDA | 26 sections |
TEMAZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9961 | CAPSULE | 15 mg | ORAL | NDA | 26 sections |
TEMAZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9962 | CAPSULE | 30 mg | ORAL | NDA | 26 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7808 | CAPSULE | 15 mg | ORAL | ANDA | 27 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7809 | CAPSULE | 30 mg | ORAL | ANDA | 27 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6436 | CAPSULE | 7.50 mg | ORAL | ANDA | 24 sections |
TEMAZEPAM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-214 | CAPSULE | 15 mg | ORAL | ANDA | 14 sections |
temazepam | Human Prescription Drug Label | 1 | 17856-0148 | CAPSULE | 15 mg | ORAL | ANDA | 23 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-282 | CAPSULE | 15 mg | ORAL | ANDA | 24 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-283 | CAPSULE | 30 mg | ORAL | ANDA | 24 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-101 | CAPSULE | 15 mg | ORAL | ANDA | 23 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-102 | CAPSULE | 30 mg | ORAL | ANDA | 23 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33358-332 | CAPSULE | 15 mg | ORAL | ANDA | 18 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-663 | CAPSULE | 30 mg | ORAL | ANDA | 23 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-663 | CAPSULE | 30 mg | ORAL | ANDA | 23 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-664 | CAPSULE | 15 mg | ORAL | ANDA | 23 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-664 | CAPSULE | 15 mg | ORAL | ANDA | 23 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-821 | CAPSULE | 22.50 mg | ORAL | ANDA | 23 sections |
temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 35356-821 | CAPSULE | 22.50 mg | ORAL | ANDA | 23 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-120 | CAPSULE | 7.50 mg | ORAL | ANDA | 17 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-121 | CAPSULE | 15 mg | ORAL | ANDA | 17 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-122 | CAPSULE | 22.50 mg | ORAL | ANDA | 17 sections |
Temazepam | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-123 | CAPSULE | 30 mg | ORAL | ANDA | 17 sections |