telmisartan ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin II receptor antagonists, antihypertensive (non-peptidic) 2583 144701-48-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • telmisartan
  • tolura
  • micardis
  • pritor
A biphenyl compound and benzimidazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION.
  • Molecular weight: 514.63
  • Formula: C33H30N4O2
  • CLOGP: 7.29
  • LIPINSKI: 2
  • HAC: 6
  • HDO: 1
  • TPSA: 72.94
  • ALOGS: -5.17
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.22 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 5.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 10, 1998 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 183.10 10.90 279 35580 95860 50473405
Blood pressure increased 99.33 10.90 261 35598 132871 50436394
Hypertensive crisis 92.87 10.90 76 35783 13078 50556187
Renal impairment 69.81 10.90 161 35698 75500 50493765
Bradycardia 67.21 10.90 144 35715 64282 50504983
Maternal exposure during pregnancy 66.04 10.90 16 35843 159762 50409503
Hypoglycaemia 65.64 10.90 128 35731 53453 50515812
Blood pressure systolic increased 64.74 10.90 101 35758 35348 50533917
Completed suicide 61.21 10.90 10 35849 131879 50437386
Labelled drug-drug interaction medication error 58.63 10.90 53 35806 10424 50558841
Hepatic function abnormal 58.13 10.90 92 35767 32589 50536676
Glaucoma 55.72 10.90 62 35797 15624 50553641
Alopecia 55.61 10.90 55 35804 244992 50324273
Labile hypertension 54.12 10.90 18 35841 453 50568812
Hyperkalaemia 53.06 10.90 110 35749 47979 50521286
Drug ineffective 51.67 10.90 355 35504 818978 49750287
Head discomfort 50.68 10.90 50 35809 10969 50558296
Acute kidney injury 50.62 10.90 305 35554 227753 50341512
Therapeutic product effect decreased 49.99 10.90 17 35842 136033 50433232
Pain 49.36 10.90 227 35632 578676 49990589
Inappropriate antidiuretic hormone secretion 46.77 10.90 52 35807 13091 50556174
Abdominal discomfort 45.96 10.90 58 35801 231583 50337682
Systemic lupus erythematosus 44.50 10.90 22 35837 140600 50428665
Lactic acidosis 43.69 10.90 82 35777 33273 50535992
Isosthenuria 43.63 10.90 11 35848 98 50569167
Asthma 42.81 10.90 150 35709 89187 50480078
Sleep apnoea syndrome 42.18 10.90 67 35792 23801 50545464
Blood pressure decreased 42.02 10.90 110 35749 55799 50513466
Glossodynia 41.50 10.90 15 35844 115554 50453711
Cerebral infarction 41.47 10.90 63 35796 21541 50547724
Carotid arteriosclerosis 41.45 10.90 18 35841 953 50568312
Listless 41.33 10.90 24 35835 2366 50566899
Off label use 40.40 10.90 186 35673 474240 50095025
Treatment failure 39.96 10.90 24 35835 137613 50431652
Infusion site streaking 39.45 10.90 14 35845 430 50568835
Death 38.62 10.90 111 35748 325268 50243997
Reduced facial expression 38.61 10.90 20 35839 1574 50567691
Postprandial hypoglycaemia 38.12 10.90 9 35850 59 50569206
Pyelitis 38.04 10.90 11 35848 171 50569094
Myalgia 37.55 10.90 181 35678 124138 50445127
Chloropsia 37.17 10.90 8 35851 32 50569233
Blood pressure inadequately controlled 36.70 10.90 28 35831 4352 50564913
Altered state of consciousness 36.67 10.90 60 35799 21850 50547415
Arthropathy 36.30 10.90 35 35824 157871 50411394
Drug specific antibody 36.07 10.90 20 35839 1805 50567460
Bladder hypertrophy 36.03 10.90 11 35848 208 50569057
Electrocardiogram PR shortened 35.40 10.90 11 35848 221 50569044
Fall 35.08 10.90 377 35482 334555 50234710
Fatigue 35.06 10.90 327 35532 707274 49861991
Blood creatinine increased 34.88 10.90 126 35733 76034 50493231
Rhabdomyolysis 34.82 10.90 82 35777 38945 50530320
Hypotension 34.63 10.90 285 35574 235184 50334081
Pericarditis 34.27 10.90 7 35852 78682 50490583
Contraindicated product administered 34.26 10.90 33 35826 148925 50420340
Product dose omission issue 33.45 10.90 49 35810 183789 50385476
Carcinoid tumour pulmonary 32.58 10.90 12 35847 411 50568854
Exposure during pregnancy 32.54 10.90 23 35836 120992 50448273
Creatinine renal clearance increased 32.36 10.90 13 35846 565 50568700
Endometriosis 31.86 10.90 25 35834 4050 50565215
Atrial fibrillation 31.34 10.90 149 35710 101596 50467669
Apathy 30.60 10.90 32 35827 7516 50561749
Product packaging confusion 30.48 10.90 9 35850 151 50569114
Hypersensitivity 30.48 10.90 67 35792 215094 50354171
Wound 29.93 10.90 19 35840 105775 50463490
Chronic kidney disease 29.62 10.90 78 35781 39693 50529572
Administration site abscess 29.47 10.90 6 35853 17 50569248
White blood cell count abnormal 29.42 10.90 27 35832 5413 50563852
Cardiac failure 29.23 10.90 119 35740 75921 50493344
Vascular purpura 28.74 10.90 15 35844 1199 50568066
Administration site induration 28.73 10.90 6 35853 20 50569245
Albuminuria 28.55 10.90 9 35850 190 50569075
Administration site discharge 28.29 10.90 6 35853 22 50569243
Blood thyroid stimulating hormone normal 28.24 10.90 8 35851 115 50569150
Delirium 27.53 10.90 74 35785 38118 50531147
Loss of consciousness 27.34 10.90 146 35713 104207 50465058
Oliguria 26.67 10.90 31 35828 8185 50561080
Product monitoring error 26.14 10.90 19 35840 2745 50566520
Administration site odour 26.01 10.90 6 35853 35 50569230
Hypertensive angiopathy 25.95 10.90 7 35852 83 50569182
Joint noise 25.89 10.90 21 35838 3566 50565699
Hypokalaemia 25.76 10.90 127 35732 87865 50481400
Dementia 25.68 10.90 43 35816 15954 50553311
Renal function test abnormal 25.62 10.90 19 35840 2830 50566435
Dizziness 25.49 10.90 365 35494 346004 50223261
Scoliosis 25.10 10.90 27 35832 6549 50562716
Gastric pH increased 24.95 10.90 6 35853 43 50569222
Muscle atrophy 24.91 10.90 26 35833 6095 50563170
Hand deformity 24.46 10.90 21 35838 100178 50469087
Blood pressure abnormal 24.22 10.90 37 35822 12710 50556555
Product use issue 24.21 10.90 43 35816 149432 50419833
Electrocardiogram PR prolongation 24.16 10.90 11 35848 652 50568613
Prescription drug used without a prescription 24.04 10.90 15 35844 1685 50567580
Product use in unapproved indication 24 10.90 28 35831 115791 50453474
Injection site cyst 23.84 10.90 6 35853 53 50569212
Allergy to metals 23.44 10.90 10 35849 507 50568758
Angioedema 23.24 10.90 69 35790 37607 50531658
Renal failure 23.21 10.90 142 35717 106491 50462774
Blood creatine phosphokinase increased 23.08 10.90 55 35804 26312 50542953
Swelling 22.73 10.90 70 35789 200802 50368463
Acquired porphyria 22.67 10.90 5 35854 23 50569242
Porphyrins urine increased 22.67 10.90 5 35854 23 50569242
Foreign body 22.01 10.90 15 35844 1956 50567309
Haemoglobin increased 21.99 10.90 18 35841 3097 50566168
Liver disorder 21.86 10.90 67 35792 37155 50532110
Blood pressure diastolic decreased 21.65 10.90 41 35818 16740 50552525
Porphyrins stool increased 21.56 10.90 5 35854 30 50569235
Irritable bowel syndrome 21.53 10.90 5 35854 51436 50517829
Administration site haemorrhage 21.46 10.90 6 35853 82 50569183
Vasoplegia syndrome 21.45 10.90 12 35847 1102 50568163
Vertigo 21.43 10.90 83 35776 51749 50517516
Carbohydrate antigen 15-3 increased 21.27 10.90 12 35847 1120 50568145
Ureteral disorder 21.26 10.90 8 35851 291 50568974
Interstitial lung disease 21.05 10.90 84 35775 53092 50516173
Endophthalmitis 20.90 10.90 17 35842 2899 50566366
Skin dystrophy 20.89 10.90 5 35854 35 50569230
Proteinuria 20.74 10.90 40 35819 16557 50552708
Staphylococcus test positive 20.58 10.90 18 35841 3388 50565877
Iodine allergy 20.52 10.90 10 35849 691 50568574
Infection 20.48 10.90 59 35800 172895 50396370
Urinary retention 20.15 10.90 52 35807 26138 50543127
Synovitis 19.73 10.90 36 35823 123829 50445436
Urine calcium/creatinine ratio increased 19.62 10.90 6 35853 114 50569151
Disease progression 18.99 10.90 24 35835 95842 50473423
Paralysis recurrent laryngeal nerve 18.96 10.90 5 35854 54 50569211
Thyroid disorder 18.93 10.90 33 35826 12644 50556621
Eczema impetiginous 18.79 10.90 4 35855 15 50569250
Thalamus haemorrhage 18.76 10.90 9 35850 601 50568664
Pemphigoid 18.70 10.90 22 35837 5885 50563380
Carcinoembryonic antigen increased 18.34 10.90 12 35847 1462 50567803
Pulse abnormal 18.17 10.90 13 35846 1832 50567433
Retinal infarction 18.12 10.90 5 35854 65 50569200
Porphyria non-acute 17.74 10.90 7 35852 290 50568975
Blood potassium increased 17.48 10.90 37 35822 16361 50552904
Dry gangrene 17.46 10.90 8 35851 481 50568784
Dehydration 17.03 10.90 174 35685 152275 50416990
Gouty arthritis 16.99 10.90 8 35851 512 50568753
Left ventricular hypertrophy 16.95 10.90 19 35840 4826 50564439
Urethral caruncle 16.93 10.90 5 35854 84 50569181
Helicobacter infection 16.92 10.90 7 35852 49695 50519570
Diabetic nephropathy 16.91 10.90 11 35848 1328 50567937
Ill-defined disorder 16.61 10.90 9 35850 54645 50514620
Left atrial dilatation 16.59 10.90 12 35847 1720 50567545
Confusional state 16.58 10.90 203 35656 185725 50383540
Impaired healing 16.57 10.90 15 35844 69771 50499494
Infusion related reaction 16.52 10.90 63 35796 169494 50399771
Electrocardiogram T wave peaked 16.44 10.90 6 35853 200 50569065
Eczema 16.37 10.90 44 35815 22658 50546607
Buttock injury 16.30 10.90 6 35853 205 50569060
Insulin-like growth factor decreased 16.18 10.90 7 35852 367 50568898
Blood pressure diastolic abnormal 16.16 10.90 26 35833 9335 50559930
Bite 16.06 10.90 7 35852 374 50568891
Subacute cutaneous lupus erythematosus 16.06 10.90 13 35846 2202 50567063
Haemorrhage subcutaneous 15.77 10.90 14 35845 2687 50566578
Hyperaldosteronism 15.60 10.90 6 35853 232 50569033
Renal tubular acidosis 15.55 10.90 11 35848 1523 50567742
Myocardial infarction 15.41 10.90 112 35747 88915 50480350
Hepatic steatosis 15.36 10.90 45 35814 24339 50544926
Protein urine present 15.34 10.90 19 35840 5358 50563907
Gamma-glutamyltransferase increased 15.28 10.90 51 35808 29572 50539693
Hypokinesia 14.72 10.90 29 35830 12188 50557077
Oxygen saturation decreased 14.36 10.90 95 35764 73153 50496112
Bradypnoea 14.23 10.90 14 35845 3060 50566205
Rubber sensitivity 13.93 10.90 11 35848 1798 50567467
Acute myocardial infarction 13.88 10.90 49 35810 29224 50540041
Blood glucose decreased 13.85 10.90 36 35823 18175 50551090
Arrhythmia 13.65 10.90 53 35806 33079 50536186
Toxic epidermal necrolysis 13.47 10.90 39 35820 20953 50548312
Sleep disorder due to a general medical condition 13.45 10.90 21 35838 7350 50561915
Drug interaction 13.33 10.90 207 35652 199414 50369851
Face oedema 13.29 10.90 35 35824 17804 50551461
Arthritis 13.27 10.90 106 35753 86615 50482650
Sinusitis 13.22 10.90 69 35790 170489 50398776
Multiple sclerosis relapse 13.16 10.90 7 35852 42957 50526308
Neutropenia 13.14 10.90 57 35802 147908 50421357
Immobile 13.06 10.90 17 35842 5037 50564228
Suicidal ideation 13.04 10.90 12 35847 55373 50513892
HLA-B*27 positive 12.98 10.90 5 35854 194 50569071
Anaemia 12.97 10.90 251 35608 252205 50317060
Thyroid mass 12.89 10.90 14 35845 3434 50565831
Cough 12.78 10.90 241 35618 241023 50328242
Menopausal symptoms 12.76 10.90 11 35848 2032 50567233
Haemophilia 12.62 10.90 4 35855 86 50569179
Compensatory sweating 12.54 10.90 3 35856 21 50569244
Visual acuity reduced 12.53 10.90 37 35822 20102 50549163
Pulmonary function test abnormal 12.37 10.90 9 35850 1302 50567963
Rash 12.36 10.90 227 35632 437244 50132021
Near drowning 12.30 10.90 3 35856 23 50569242
Pericardial effusion 12.27 10.90 43 35816 25546 50543719
Gastrointestinal bacterial infection 12.20 10.90 7 35852 675 50568590
Blood pressure fluctuation 12.16 10.90 54 35805 35769 50533496
Therapeutic drug monitoring analysis not performed 11.98 10.90 7 35852 698 50568567
Fluid retention 11.89 10.90 11 35848 50638 50518627
Idiosyncratic drug reaction 11.83 10.90 7 35852 714 50568551
Breast cancer recurrent 11.75 10.90 14 35845 3794 50565471
Affect lability 11.63 10.90 22 35837 8976 50560289
Haemorrhagic infarction 11.60 10.90 5 35854 260 50569005
Spinal stenosis 11.57 10.90 28 35831 13522 50555743
Hypertension 11.54 10.90 212 35647 210991 50358274
Injection site paraesthesia 11.50 10.90 6 35853 479 50568786
Enteritis 11.49 10.90 19 35840 6976 50562289
Ventricular fibrillation 11.46 10.90 24 35835 10535 50558730
Bradyarrhythmia 11.45 10.90 10 35849 1880 50567385
Blood pressure systolic abnormal 11.43 10.90 20 35839 7686 50561579
Bronchiolitis 11.31 10.90 11 35848 2370 50566895
Atrioventricular block 11.19 10.90 18 35841 6460 50562805
Shock 11.05 10.90 36 35823 20614 50548651
Fibrin degradation products increased 11 10.90 4 35855 132 50569133
Glomerular filtration rate decreased 10.96 10.90 25 35834 11627 50557638
Intracardiac mass 10.94 10.90 3 35856 38 50569227
Psoriasis 10.92 10.90 85 35774 68915 50500350

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 108.60 11.70 119 25052 24556 29524800
Interstitial lung disease 85.52 11.70 166 25005 57552 29491804
Hyperkalaemia 58.52 11.70 148 25023 61244 29488112
Death 58.49 11.70 128 25043 341956 29207400
Hepatic function abnormal 55.80 11.70 111 25060 39148 29510208
Pericardial disease 54.58 11.70 18 25153 364 29548992
Completed suicide 50.81 11.70 8 25163 90238 29459118
Blood creatine phosphokinase increased 50.80 11.70 109 25062 40535 29508821
Pulmonary valve disease 50.57 11.70 16 25155 282 29549074
Cardiac failure 46.65 11.70 161 25010 79126 29470230
Growth hormone deficiency 45.98 11.70 14 25157 216 29549140
Altered state of consciousness 44.94 11.70 69 25102 19820 29529536
Toxicity to various agents 41.67 11.70 52 25119 173609 29375747
Physical examination abnormal 35.48 11.70 12 25159 263 29549093
Blood pressure increased 33.54 11.70 138 25033 73665 29475691
Diabetic nephropathy 31.97 11.70 20 25151 1875 29547481
Stenosis 31.19 11.70 16 25155 1025 29548331
Liver disorder 30.81 11.70 71 25100 27678 29521678
Drug intolerance 30.35 11.70 3 25168 48376 29500980
Renal impairment 30.08 11.70 143 25028 81190 29468166
Lactic acidosis 29.93 11.70 74 25097 30173 29519183
Product dose omission issue 29.85 11.70 23 25148 96360 29452996
Post micturition dribble 29.52 11.70 6 25165 13 29549343
Cardiac discomfort 29.07 11.70 12 25159 464 29548892
Ventricular arrhythmia 29.04 11.70 27 25144 4577 29544779
Daydreaming 28.92 11.70 12 25159 470 29548886
Accident at work 28.75 11.70 13 25158 629 29548727
IgA nephropathy 28.10 11.70 15 25156 1043 29548313
Hyponatraemia 27.29 11.70 122 25049 67511 29481845
Neutropenia 27.04 11.70 44 25127 131667 29417689
Narrow anterior chamber angle 26.93 11.70 8 25163 113 29549243
Chronic kidney disease 26.90 11.70 80 25091 36336 29513020
Rales 25.95 11.70 32 25139 7478 29541878
Off label use 25.51 11.70 151 25020 300649 29248707
Dyslalia 25.37 11.70 11 25160 481 29548875
Tricuspid valve incompetence 24.65 11.70 33 25138 8361 29540995
Staring 24.40 11.70 15 25156 1364 29547992
Atrioventricular block complete 24.31 11.70 32 25139 7979 29541377
Bundle branch block left 24.16 11.70 26 25145 5251 29544105
Mitral valve disease 23.57 11.70 14 25157 1196 29548160
Labile blood pressure 23.55 11.70 11 25160 574 29548782
Petit mal epilepsy 23.30 11.70 19 25152 2703 29546653
Syncope 23.13 11.70 133 25038 81238 29468118
Blood pressure decreased 23.03 11.70 88 25083 45389 29503967
Hypoglycaemic coma 22.64 11.70 17 25154 2146 29547210
Dyspnoea at rest 22.53 11.70 20 25151 3194 29546162
Loss of consciousness 22.34 11.70 123 25048 73933 29475423
Incontinence 21.65 11.70 24 25147 5008 29544348
Hypoglycaemia 21.63 11.70 90 25081 48256 29501100
Drug eruption 21.02 11.70 45 25126 16696 29532660
Face oedema 20.91 11.70 34 25137 10249 29539107
Mitral valve incompetence 20.59 11.70 39 25132 13254 29536102
Product packaging confusion 20.51 11.70 5 25166 31 29549325
Carotid artery stenosis 20.42 11.70 22 25149 4447 29544909
Haematuria 20.40 11.70 83 25088 44056 29505300
Rhabdomyolysis 20.39 11.70 104 25067 60704 29488652
Drug-induced liver injury 20.39 11.70 52 25119 21603 29527753
Myocardial rupture 20.30 11.70 7 25164 163 29549193
Drug ineffective 19.72 11.70 206 24965 362964 29186392
Transient aphasia 19.62 11.70 6 25165 94 29549262
Chylothorax 19.46 11.70 10 25161 643 29548713
Echocardiogram abnormal 19.41 11.70 11 25160 860 29548496
Blood urea increased 19.11 11.70 60 25111 28052 29521304
Blood pressure inadequately controlled 19.06 11.70 16 25155 2370 29546986
Drug abuse 19.04 11.70 24 25147 79859 29469497
Renal artery restenosis 18.75 11.70 4 25167 12 29549344
Hyperuricaemia 18.60 11.70 26 25145 6863 29542493
Anaplastic astrocytoma 18.59 11.70 6 25165 113 29549243
Pericoronitis 18.21 11.70 3 25168 0 29549356
Diastolic dysfunction 18.18 11.70 22 25149 5042 29544314
Pain 17.92 11.70 80 25091 171352 29378004
Nodal arrhythmia 17.84 11.70 10 25161 766 29548590
Left ventricle outflow tract obstruction 17.76 11.70 6 25165 131 29549225
Diabetes mellitus 17.70 11.70 74 25097 39757 29509599
Upper respiratory tract inflammation 17.55 11.70 13 25158 1607 29547749
Pneumonitis chemical 17.31 11.70 6 25165 142 29549214
Bradyarrhythmia 17.30 11.70 14 25157 1971 29547385
Postrenal failure 17.13 11.70 8 25163 417 29548939
Drug hypersensitivity 16.88 11.70 20 25151 68386 29480970
Sprue-like enteropathy 16.87 11.70 8 25163 432 29548924
Blood creatinine increased 16.81 11.70 127 25044 84975 29464381
Dissociation 16.78 11.70 11 25160 1118 29548238
Ejection fraction decreased 16.77 11.70 40 25131 15938 29533418
Renal artery arteriosclerosis 16.66 11.70 4 25167 23 29549333
Hepatojugular reflux 16.24 11.70 8 25163 470 29548886
Electrocardiogram Q wave abnormal 16.11 11.70 7 25164 308 29549048
Gastric cancer 15.88 11.70 20 25151 4774 29544582
Blood testosterone free increased 15.86 11.70 4 25167 29 29549327
Gastric ulcer haemorrhage 15.49 11.70 20 25151 4894 29544462
Haemorrhagic transformation stroke 15.33 11.70 11 25160 1295 29548061
Lens dislocation 15.31 11.70 5 25166 98 29549258
Acute kidney injury 15.18 11.70 313 24858 264954 29284402
Foetal exposure during pregnancy 15.08 11.70 5 25166 33862 29515494
Occult blood 14.91 11.70 8 25163 562 29548794
Decreased appetite 14.90 11.70 189 24982 145153 29404203
Left ventricular dysfunction 14.90 11.70 27 25144 8875 29540481
Hypocalcaemia 14.88 11.70 45 25126 20620 29528736
Diverticulum intestinal haemorrhagic 14.79 11.70 13 25158 2049 29547307
Blood cholinesterase decreased 14.60 11.70 5 25166 114 29549242
Gastric ulcer 14.54 11.70 35 25136 14026 29535330
Bulbar palsy 14.51 11.70 6 25165 233 29549123
Tubulointerstitial nephritis 14.22 11.70 40 25131 17603 29531753
Hepatitis acute 14.00 11.70 22 25149 6440 29542916
Prostatism 13.96 11.70 6 25165 257 29549099
Treatment failure 13.94 11.70 7 25164 36932 29512424
Anaemia macrocytic 13.92 11.70 14 25157 2614 29546742
Melaena 13.91 11.70 58 25113 31118 29518238
Progesterone increased 13.82 11.70 3 25168 10 29549346
Coronary artery stenosis 13.09 11.70 25 25146 8548 29540808
Alkalosis hypochloraemic 12.99 11.70 6 25165 305 29549051
Cardiomegaly 12.88 11.70 33 25138 13743 29535613
Anxiety 12.87 11.70 34 25137 85331 29464025
Congenital brain damage 12.85 11.70 3 25168 15 29549341
Drug level increased 12.68 11.70 40 25131 18747 29530609
Trigemino-cardiac reflex 12.61 11.70 5 25166 174 29549182
Colon cancer 12.53 11.70 23 25148 7632 29541724
Haemorrhage subcutaneous 12.52 11.70 12 25159 2113 29547243
Blood pressure systolic increased 12.43 11.70 37 25134 16808 29532548
Drug interaction 12.30 11.70 236 24935 197149 29352207
Arrhythmia 12.25 11.70 56 25115 31257 29518099
Cerebral haemorrhage 12.14 11.70 56 25115 31370 29517986
Product use in unapproved indication 12.06 11.70 36 25135 86839 29462517
Enterocolitis haemorrhagic 11.95 11.70 8 25163 842 29548514
Jaundice 11.92 11.70 53 25118 29243 29520113
Hospitalisation 11.83 11.70 13 25158 45975 29503381
Neuropathy peripheral 11.71 11.70 27 25144 71000 29478356

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cerebral infarction 144.07 10.42 171 51475 40873 64406213
Hyponatraemia 136.83 10.42 340 51306 147999 64299087
Completed suicide 130.23 10.42 14 51632 224400 64222686
Hepatic function abnormal 89.49 10.42 174 51472 64139 64382947
Blood pressure increased 88.94 10.42 322 51324 172230 64274856
Hyperkalaemia 84.07 10.42 223 51423 100906 64346180
Death 81.54 10.42 165 51481 482540 63964546
Hypertensive crisis 81.10 10.42 86 51560 18162 64428924
Interstitial lung disease 74.73 10.42 209 51437 97523 64349563
Altered state of consciousness 74.02 10.42 119 51527 37783 64409303
Renal impairment 67.88 10.42 250 51396 134767 64312319
Hypoglycaemia 66.54 10.42 190 51456 89702 64357384
Cardiac failure 65.62 10.42 244 51402 132129 64314957
Blood pressure systolic increased 61.85 10.42 128 51518 49325 64397761
Off label use 58.19 10.42 285 51361 632521 63814565
Lactic acidosis 57.85 10.42 142 51504 61268 64385818
Bradycardia 57.83 10.42 217 51429 118002 64329084
Chronic kidney disease 55.70 10.42 135 51511 57784 64389302
Glaucoma 55.52 10.42 67 51579 16281 64430805
Blood creatine phosphokinase increased 54.73 10.42 135 51511 58423 64388663
Diabetic nephropathy 54.22 10.42 31 51615 2623 64444463
Labile hypertension 53.52 10.42 19 51627 515 64446571
Pulmonary valve disease 53.50 10.42 16 51630 247 64446839
Pericardial disease 50.77 10.42 18 51628 486 64446600
Blood pressure decreased 50.56 10.42 168 51478 86031 64361055
Pain 50.43 10.42 250 51396 553261 63893825
Product packaging confusion 46.76 10.42 14 51632 217 64446869
Acute kidney injury 44.89 10.42 553 51093 448687 63998399
Liver disorder 44.67 10.42 118 51528 53233 64393853
Maternal exposure during pregnancy 44.45 10.42 11 51635 95873 64351213
Product dose omission issue 43.72 10.42 55 51591 194692 64252394
Therapeutic product effect decreased 43.37 10.42 19 51627 115332 64331754
Toxicity to various agents 42.50 10.42 149 51497 363364 64083722
Isosthenuria 41.99 10.42 11 51635 101 64446985
Physical examination abnormal 41.10 10.42 13 51633 244 64446842
Head discomfort 41.00 10.42 49 51597 11785 64435301
Growth hormone deficiency 41.00 10.42 14 51632 337 64446749
Drug ineffective 40.69 10.42 454 51192 839793 63607293
Rhabdomyolysis 39.67 10.42 162 51484 91564 64355522
Infusion site streaking 37.69 10.42 14 51632 433 64446653
Pemphigus 37.27 10.42 3 51643 60698 64386388
Myalgia 36.11 10.42 234 51412 158383 64288703
Endometriosis 35.21 10.42 24 51622 2768 64444318
Postprandial hypoglycaemia 35.03 10.42 9 51637 76 64447010
Alopecia 34.93 10.42 49 51597 165641 64281445
Sleep apnoea syndrome 34.72 10.42 75 51571 29757 64417329
Inappropriate antidiuretic hormone secretion 34.33 10.42 63 51583 22226 64424860
Carcinoid tumour pulmonary 33.95 10.42 12 51634 321 64446765
Carotid arteriosclerosis 33.90 10.42 21 51625 2058 64445028
Listless 33.90 10.42 25 51621 3265 64443821
Blood creatinine increased 33.82 10.42 205 51441 135577 64311509
Product use in unapproved indication 33.62 10.42 56 51590 176562 64270524
Neutropenia 33.09 10.42 91 51555 239533 64207553
Electrocardiogram PR shortened 32.36 10.42 11 51635 261 64446825
Creatinine renal clearance increased 31.97 10.42 15 51631 841 64446245
Treatment failure 31.81 10.42 28 51618 116788 64330298
Pyelitis 31.71 10.42 11 51635 278 64446808
Drug specific antibody 31.25 10.42 20 51626 2075 64445011
Product monitoring error 30.28 10.42 29 51617 5425 64441661
Oliguria 30.16 10.42 47 51599 14529 64432557
Loss of consciousness 29.66 10.42 212 51434 148153 64298933
White blood cell count abnormal 29.23 10.42 27 51619 4827 64442259
Hypersensitivity 29.11 10.42 72 51574 196380 64250706
Administration site induration 28.74 10.42 6 51640 17 64447069
Administration site abscess 28.74 10.42 6 51640 17 64447069
Reduced facial expression 28.65 10.42 19 51627 2094 64444992
Labelled drug-drug interaction medication error 28.63 10.42 58 51588 22004 64425082
Fall 28.38 10.42 480 51166 416346 64030740
Arthropathy 28.37 10.42 33 51613 120934 64326152
Infection 27.99 10.42 67 51579 184813 64262273
Atrioventricular block complete 27.78 10.42 45 51601 14373 64432713
Blood thyroid stimulating hormone normal 27.15 10.42 8 51638 117 64446969
Asthma 27.12 10.42 149 51497 95076 64352010
Haematuria 27.09 10.42 108 51538 60363 64386723
Pemphigoid 27.04 10.42 42 51604 12944 64434142
Administration site discharge 26.95 10.42 6 51640 25 64447061
Endophthalmitis 26.93 10.42 27 51619 5338 64441748
Administration site odour 26.76 10.42 6 51640 26 64447060
Drug intolerance 26.24 10.42 71 51575 187921 64259165
Exposure during pregnancy 25.88 10.42 15 51631 77660 64369426
Staphylococcus test positive 25.78 10.42 27 51619 5618 64441468
Pericarditis 25.63 10.42 9 51637 62507 64384579
Drug hypersensitivity 25.46 10.42 101 51545 237714 64209372
IgA nephropathy 24.70 10.42 15 51631 1419 64445667
Narrow anterior chamber angle 24.63 10.42 8 51638 164 64446922
Dizziness 24.59 10.42 482 51164 429681 64017405
Diabetes mellitus 24.58 10.42 112 51534 66362 64380724
Bladder hypertrophy 24.57 10.42 11 51635 553 64446533
Product use issue 24.57 10.42 53 51593 151662 64295424
Hypertension 24.48 10.42 316 51330 258945 64188141
Accident at work 24.30 10.42 13 51633 966 64446120
Dyslalia 24.22 10.42 13 51633 972 64446114
Administration site haemorrhage 24.22 10.42 6 51640 43 64447043
Haemoglobin increased 23.98 10.42 25 51621 5176 64441910
Hypertensive angiopathy 23.91 10.42 7 51639 100 64446986
Abdominal discomfort 23.86 10.42 71 51575 182251 64264835
Stenosis 23.84 10.42 16 51630 1799 64445287
Daydreaming 23.66 10.42 12 51634 798 64446288
Gastric pH increased 23.32 10.42 6 51640 51 64447035
Blood pressure inadequately controlled 23.26 10.42 25 51621 5359 64441727
Atrial fibrillation 23.21 10.42 224 51422 170865 64276221
Bundle branch block left 23.09 10.42 34 51612 10000 64437086
Bradyarrhythmia 22.81 10.42 21 51625 3737 64443349
Drug interaction 22.49 10.42 411 51235 361672 64085414
Scoliosis 22.42 10.42 26 51620 6056 64441030
Haemorrhage subcutaneous 21.99 10.42 22 51624 4339 64442747
Injection site cyst 21.85 10.42 6 51640 67 64447019
Joint noise 21.58 10.42 19 51627 3192 64443894
Blood urea increased 21.53 10.42 81 51565 44072 64403014
Fatigue 21.52 10.42 447 51199 748283 63698803
Carbohydrate antigen 15-3 increased 21.43 10.42 12 51634 975 64446111
Porphyrins urine increased 21.09 10.42 5 51641 29 64447057
Sprue-like enteropathy 20.97 10.42 12 51634 1017 64446069
Glossodynia 20.85 10.42 13 51633 64683 64382403
Prescription drug used without a prescription 20.78 10.42 17 51629 2583 64444503
Renal tubular acidosis 20.77 10.42 18 51628 2961 64444125
Hypoglycaemic coma 20.52 10.42 21 51625 4253 64442833
Cardiac discomfort 20.34 10.42 12 51634 1077 64446009
Albuminuria 20.05 10.42 10 51636 642 64446444
Acquired porphyria 20.04 10.42 5 51641 37 64447049
Irritable bowel syndrome 20.03 10.42 3 51643 37366 64409720
Renal failure 19.99 10.42 228 51418 181460 64265626
Ventricular arrhythmia 19.84 10.42 27 51619 7388 64439698
Swelling 19.82 10.42 64 51582 160154 64286932
Staring 19.78 10.42 16 51630 2394 64444692
Muscle atrophy 19.54 10.42 31 51615 9727 64437359
Systemic lupus erythematosus 19.49 10.42 20 51626 77592 64369494
Cardiomegaly 19.43 10.42 52 51594 23632 64423454
Arrhythmia 19.42 10.42 89 51557 52855 64394231
Gastric ulcer haemorrhage 19.33 10.42 28 51618 8115 64438971
Porphyrins stool increased 19.28 10.42 5 51641 44 64447042
Drug abuse 19.22 10.42 49 51597 132325 64314761
Renal artery restenosis 18.99 10.42 4 51642 12 64447074
Skin dystrophy 18.98 10.42 5 51641 47 64447039
Drug-induced liver injury 18.92 10.42 82 51564 47561 64399525
Apathy 18.90 10.42 33 51613 11199 64435887
Melaena 18.89 10.42 89 51557 53459 64393627
Syncope 18.79 10.42 201 51445 157434 64289652
Carcinoembryonic antigen increased 18.77 10.42 14 51632 1859 64445227
Pulse abnormal 18.41 10.42 16 51630 2641 64444445
Synovitis 18.31 10.42 32 51614 99058 64348028
Rheumatoid factor positive 18.28 10.42 3 51643 34935 64412151
Thalamus haemorrhage 18.27 10.42 13 51633 1606 64445480
Delirium 18.20 10.42 106 51540 69088 64377998
Renal function test abnormal 18.14 10.42 19 51627 3955 64443131
Face oedema 17.98 10.42 52 51594 24709 64422377
Buttock injury 17.95 10.42 6 51640 135 64446951
Mitral valve incompetence 17.93 10.42 53 51593 25485 64421601
Electrocardiogram Q wave abnormal 17.88 10.42 8 51638 402 64446684
Product used for unknown indication 17.78 10.42 10 51636 820 64446266
Hypokalaemia 17.72 10.42 162 51484 121741 64325345
Urine calcium/creatinine ratio increased 17.67 10.42 6 51640 142 64446944
Anaplastic astrocytoma 17.55 10.42 6 51640 145 64446941
Diverticulum intestinal haemorrhagic 17.43 10.42 17 51629 3252 64443834
Rales 17.39 10.42 38 51608 15191 64431895
Serotonin syndrome 17.27 10.42 5 51641 39277 64407809
Vertigo 17.24 10.42 93 51553 58918 64388168
Contraindicated product administered 17.18 10.42 38 51608 107791 64339295
Colon cancer 17.14 10.42 34 51612 12705 64434381
Vascular purpura 16.93 10.42 15 51631 2541 64444545
Urethral caruncle 16.91 10.42 5 51641 74 64447012
Transient aphasia 16.75 10.42 6 51640 167 64446919
Cerebral haemorrhage 16.65 10.42 83 51563 51007 64396079
Mitral valve disease 16.52 10.42 15 51631 2623 64444463
Blood pressure abnormal 16.46 10.42 36 51610 14399 64432687
Gastric cancer 16.40 10.42 23 51623 6470 64440616
Drug resistance 16.31 10.42 4 51642 35098 64411988
Ureteral disorder 16.28 10.42 8 51638 497 64446589
Petit mal epilepsy 16.08 10.42 20 51626 5012 64442074
HLA-B*27 positive 16.06 10.42 5 51641 89 64446997
Duodenal ulcer perforation 15.99 10.42 4 51642 34621 64412465
Hepatojugular reflux 15.96 10.42 8 51638 519 64446567
Disease progression 15.90 10.42 59 51587 141621 64305465
Febrile neutropenia 15.76 10.42 87 51559 187570 64259516
Drug eruption 15.75 10.42 64 51582 36072 64411014
Hypotension 15.50 10.42 407 51239 380567 64066519
Dementia 15.45 10.42 44 51602 20722 64426364
Labile blood pressure 15.38 10.42 13 51633 2067 64445019
Upper respiratory tract inflammation 15.36 10.42 17 51629 3765 64443321
Renal artery arteriosclerosis 15.34 10.42 4 51642 36 64447050
Electrocardiogram PR prolongation 15.33 10.42 11 51635 1376 64445710
Postrenal failure 15.32 10.42 8 51638 566 64446520
Tubulointerstitial nephritis 15.31 10.42 57 51589 30852 64416234
Hyperaldosteronism 15.15 10.42 7 51639 379 64446707
Agitation 15.03 10.42 30 51616 88337 64358749
Glycosylated haemoglobin increased 15.03 10.42 37 51609 15982 64431104
Blood cholinesterase decreased 15.01 10.42 6 51640 227 64446859
Echocardiogram abnormal 14.94 10.42 12 51634 1777 64445309
Myocardial rupture 14.86 10.42 6 51640 233 64446853
Breast cancer recurrent 14.84 10.42 14 51632 2569 64444517
Suicidal ideation 14.70 10.42 19 51627 66523 64380563
Urinary retention 14.69 10.42 78 51568 49123 64397963
Blood potassium increased 14.66 10.42 50 51596 25930 64421156
Nodal arrhythmia 14.63 10.42 12 51634 1831 64445255
Tricuspid valve incompetence 14.63 10.42 38 51608 16965 64430121
Paralysis recurrent laryngeal nerve 14.54 10.42 5 51641 123 64446963
Bite 14.46 10.42 7 51639 421 64446665
Drug level increased 14.46 10.42 60 51586 34136 64412950
Product substitution issue 14.43 10.42 39 51607 17822 64429264
Anaemia 14.39 10.42 401 51245 378279 64068807
Bulbar palsy 14.33 10.42 6 51640 256 64446830
Thyroid disorder 14.30 10.42 30 51616 11662 64435424
Lens dislocation 14.28 10.42 5 51641 130 64446956
Carotid artery stenosis 14.24 10.42 24 51622 7917 64439169
Hypokinesia 14.18 10.42 37 51609 16559 64430527
Hospitalisation 14.15 10.42 24 51622 75183 64371903
Menopausal symptoms 13.99 10.42 11 51635 1579 64445507
Gamma-glutamyltransferase increased 13.87 10.42 76 51570 48434 64398652
Rash 13.65 10.42 272 51374 458277 63988809
Impaired healing 13.64 10.42 17 51629 60456 64386630
Multiple sclerosis relapse 13.62 10.42 8 51638 41127 64405959
Platelet count decreased 13.60 10.42 199 51447 167512 64279574
Blood pressure diastolic decreased 13.54 10.42 44 51602 22257 64424829
Hyperuricaemia 13.47 10.42 27 51619 10164 64436922
Foreign body 13.42 10.42 13 51633 2466 64444620
Dehydration 13.41 10.42 246 51400 216517 64230569
Sinusitis 13.17 10.42 66 51580 145862 64301224
Aortic dissection 13.14 10.42 15 51631 3437 64443649
Neurotoxicity 12.98 10.42 3 51643 27401 64419685
Folliculitis 12.91 10.42 4 51642 30073 64417013
Hypersensitivity vasculitis 12.88 10.42 21 51625 6740 64440346
Pancreatitis acute 12.83 10.42 68 51578 42787 64404299
Hyperlipidaemia 12.77 10.42 44 51602 22932 64424154
Insulin-like growth factor decreased 12.71 10.42 7 51639 551 64446535
Mucosal inflammation 12.70 10.42 19 51627 62565 64384521
Ejection fraction decreased 12.64 10.42 51 51595 28656 64418430
Respiratory distress 12.56 10.42 14 51632 52317 64394769
Pneumonitis chemical 12.55 10.42 6 51640 351 64446735
Orthostatic hypotension 12.55 10.42 72 51574 46666 64400420
Jaundice 12.55 10.42 74 51572 48438 64398648
Dyspnoea at rest 12.53 10.42 20 51626 6309 64440777
Enteritis 12.52 10.42 29 51617 12048 64435038
Bronchiolitis 12.49 10.42 15 51631 3626 64443460
Pulmonary function test abnormal 12.47 10.42 14 51632 3150 64443936
Erythema multiforme 12.40 10.42 34 51612 15667 64431419
Retinal infarction 12.39 10.42 5 51641 194 64446892
Peripheral arterial occlusive disease 12.37 10.42 21 51625 6966 64440120
Infusion related reaction 12.35 10.42 79 51567 164388 64282698
Left ventricular hypertrophy 12.34 10.42 25 51621 9481 64437605
Hypocalcaemia 12.33 10.42 66 51580 41687 64405399
Diastolic dysfunction 12.32 10.42 24 51622 8851 64438235
Chronic gastritis 12.20 10.42 14 51632 3226 64443860
Injection site bruising 12.15 10.42 7 51639 36366 64410720
Musculoskeletal stiffness 12.13 10.42 54 51592 123152 64323934
Troponin T increased 12.10 10.42 12 51634 2341 64444745
Helicobacter infection 11.96 10.42 8 51638 38354 64408732
Pallor 11.93 10.42 62 51584 38719 64408367
Guttate psoriasis 11.89 10.42 6 51640 395 64446691
Hand deformity 11.84 10.42 20 51626 62751 64384335
Embolic stroke 11.66 10.42 20 51626 6691 64440395
Bile duct cancer 11.52 10.42 8 51638 950 64446136
Haemophilia 11.50 10.42 4 51642 102 64446984
Blood pressure fluctuation 11.47 10.42 76 51570 51795 64395291
Hemiplegia 11.46 10.42 29 51617 12739 64434347
Ocular pemphigoid 11.46 10.42 4 51642 103 64446983
Trigemino-cardiac reflex 11.41 10.42 5 51641 239 64446847
Gouty arthritis 11.32 10.42 9 51637 1313 64445773
Subacute cutaneous lupus erythematosus 11.27 10.42 13 51633 3012 64444074
Alkalosis hypochloraemic 11.11 10.42 6 51640 454 64446632
Porphyria non-acute 11.05 10.42 7 51639 714 64446372
Near drowning 10.96 10.42 3 51643 33 64447053
Cerebellar haemorrhage 10.96 10.42 12 51634 2625 64444461
Blood lactate dehydrogenase increased 10.96 10.42 54 51592 33024 64414062
Cardiac failure chronic 10.83 10.42 23 51623 9018 64438068
Coronary artery disease 10.73 10.42 84 51562 60349 64386737
Blood pressure diastolic abnormal 10.63 10.42 27 51619 11890 64435196
Lipids abnormal 10.58 10.42 6 51640 500 64446586
Primary hyperaldosteronism 10.50 10.42 4 51642 133 64446953
Vasoplegia syndrome 10.49 10.42 12 51634 2755 64444331
Proteinuria 10.46 10.42 47 51599 27676 64419410
Pericoronitis 10.44 10.42 3 51643 40 64447046
Decreased appetite 10.43 10.42 297 51349 280992 64166094

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09CA07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
Angiotensin II receptor blockers (ARBs), plain
ATC C09DA07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and diuretics
ATC C09DB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
FDA MoA N0000000070 Angiotensin 2 Receptor Antagonists
FDA EPC N0000175561 Angiotensin 2 Receptor Blocker
MeSH PA D047228 Angiotensin II Type 1 Receptor Blockers
MeSH PA D057911 Angiotensin Receptor Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
CHEBI has role CHEBI:35457 ACE inhibitor
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:61016 angiotensin receptor antagonists
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Cerebrovascular accident indication 230690007
Myocardial Infarction Prevention indication
Chronic heart failure off-label use 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Diabetic renal disease off-label use 127013003
Diastolic heart failure off-label use 418304008 DOID:9775
Nondiabetic Proteinuric Nephropathy off-label use
Anuria contraindication 2472002 DOID:2983
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Azotemia contraindication 445009001
Severe Aortic Valve Stenosis contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

ProductApplicantIngredients
Semintra Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.65 acidic
pKa2 5.79 Basic
pKa3 5.13 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
80MG MICARDIS BOEHRINGER INGELHEIM N020850 Nov. 10, 1998 RX TABLET ORAL 8003679 Oct. 6, 2022 TREATMENT OR PREVENTION OF STROKE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Type-1 angiotensin II receptor GPCR ANTAGONIST IC50 9.31 CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel EC50 5.49 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor EC50 5.82 CHEMBL
Type-2 angiotensin II receptor GPCR IC50 9.48 CHEMBL
Angiotensin-converting enzyme Enzyme Ki 5.22 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.75 CHEMBL
Type-1B angiotensin II receptor GPCR IC50 8.52 CHEMBL
Type-1A angiotensin II receptor GPCR Ki 9.64 CHEMBL

External reference:

IDSource
4021146 VUID
N0000148599 NUI
D00627 KEGG_DRUG
4021146 VANDF
C0248719 UMLSCUI
CHEBI:9434 CHEBI
TLS PDB_CHEM_ID
CHEMBL1017 ChEMBL_ID
D000077333 MESH_DESCRIPTOR_UI
DB00966 DRUGBANK_ID
592 IUPHAR_LIGAND_ID
7144 INN_ID
U5SYW473RQ UNII
65999 PUBCHEM_CID
218353 RXNORM
13913 MMSL
53287 MMSL
7789 MMSL
d04364 MMSL
007683 NDDF
129487008 SNOMEDCT_US
387069000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0545 TABLET 40 mg ORAL NDA authorized generic 27 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0546 TABLET 80 mg ORAL NDA authorized generic 27 sections
telmisartan and hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0054-0547 TABLET 80 mg ORAL NDA authorized generic 27 sections
Telmisartan and Amlodipine HUMAN PRESCRIPTION DRUG LABEL 2 0378-1075 TABLET 40 mg ORAL ANDA 28 sections
Telmisartan and Amlodipine HUMAN PRESCRIPTION DRUG LABEL 2 0378-1076 TABLET 40 mg ORAL ANDA 28 sections
Telmisartan and Amlodipine HUMAN PRESCRIPTION DRUG LABEL 2 0378-1077 TABLET 80 mg ORAL ANDA 28 sections
Telmisartan and Amlodipine HUMAN PRESCRIPTION DRUG LABEL 2 0378-1078 TABLET 80 mg ORAL ANDA 28 sections
Telmisartan HUMAN PRESCRIPTION DRUG LABEL 1 0378-2920 TABLET 20 mg ORAL ANDA 28 sections
Telmisartan HUMAN PRESCRIPTION DRUG LABEL 1 0378-2921 TABLET 40 mg ORAL ANDA 28 sections
Telmisartan HUMAN PRESCRIPTION DRUG LABEL 1 0378-2922 TABLET 80 mg ORAL ANDA 28 sections
Micardis HUMAN PRESCRIPTION DRUG LABEL 1 0597-0039 TABLET 20 mg ORAL NDA 26 sections
Micardis HUMAN PRESCRIPTION DRUG LABEL 1 0597-0040 TABLET 40 mg ORAL NDA 26 sections
Micardis HUMAN PRESCRIPTION DRUG LABEL 1 0597-0041 TABLET 80 mg ORAL NDA 26 sections
Micardis HCT HUMAN PRESCRIPTION DRUG LABEL 2 0597-0042 TABLET 80 mg ORAL NDA 30 sections
Micardis HCT HUMAN PRESCRIPTION DRUG LABEL 2 0597-0043 TABLET 40 mg ORAL NDA 30 sections
Micardis HCT HUMAN PRESCRIPTION DRUG LABEL 2 0597-0044 TABLET 80 mg ORAL NDA 30 sections
Telmisartan HUMAN PRESCRIPTION DRUG LABEL 1 0781-5372 TABLET 20 mg ORAL ANDA 26 sections
Telmisartan HUMAN PRESCRIPTION DRUG LABEL 1 0781-5374 TABLET 40 mg ORAL ANDA 26 sections
Telmisartan HUMAN PRESCRIPTION DRUG LABEL 1 0781-5378 TABLET 80 mg ORAL ANDA 26 sections
TELMISARTAN HUMAN PRESCRIPTION DRUG LABEL 1 13668-156 TABLET 20 mg ORAL ANDA 18 sections
TELMISARTAN HUMAN PRESCRIPTION DRUG LABEL 1 13668-156 TABLET 20 mg ORAL ANDA 18 sections
TELMISARTAN HUMAN PRESCRIPTION DRUG LABEL 1 13668-157 TABLET 40 mg ORAL ANDA 18 sections
TELMISARTAN HUMAN PRESCRIPTION DRUG LABEL 1 13668-157 TABLET 40 mg ORAL ANDA 18 sections
TELMISARTAN HUMAN PRESCRIPTION DRUG LABEL 1 13668-158 TABLET 80 mg ORAL ANDA 18 sections
TELMISARTAN HUMAN PRESCRIPTION DRUG LABEL 1 13668-158 TABLET 80 mg ORAL ANDA 18 sections
telmisartan and hydrochlorthiazide HUMAN PRESCRIPTION DRUG LABEL 2 13668-159 TABLET 40 mg ORAL ANDA 26 sections
telmisartan and hydrochlorthiazide HUMAN PRESCRIPTION DRUG LABEL 2 13668-159 TABLET 40 mg ORAL ANDA 26 sections
telmisartan and hydrochlorthiazide HUMAN PRESCRIPTION DRUG LABEL 2 13668-160 TABLET 80 mg ORAL ANDA 26 sections
telmisartan and hydrochlorthiazide HUMAN PRESCRIPTION DRUG LABEL 2 13668-160 TABLET 80 mg ORAL ANDA 26 sections
telmisartan and hydrochlorthiazide HUMAN PRESCRIPTION DRUG LABEL 2 13668-161 TABLET 80 mg ORAL ANDA 26 sections