teicoplanin aglycone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
glycopeptide antibacterials (Actinoplanes strains)	2580	89139-42-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

teicoplanin aglycon
aglucoteicoplanin
Antibiotic A 41030B
teicoplanin aglycone

Molecular weight: 1198.93
Formula: C58H45Cl2N7O18
CLOGP: 1.53
LIPINSKI: 3
HAC: 25
HDO: 15
TPSA: 407.22
ALOGS: -4.69
ROTB: 1

Drug dosage:

None

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	9.53 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1988	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.55	acidic
pKa2	7.8	acidic
pKa3	8.46	acidic
pKa4	9.01	acidic
pKa5	9.68	acidic
pKa6	11.33	acidic
pKa7	11.88	acidic
pKa8	12.31	acidic
pKa9	12.56	acidic
pKa10	12.97	acidic
pKa11	13.45	acidic
pKa12	13.96	acidic
pKa13	7.17	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cathepsin L1	Enzyme	P07711	CATL1_HUMAN	INHIBITOR	IC50	5.78		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
C0076062	UMLSCUI
CHEBI:135904	CHEBI
CHEMBL2348244	ChEMBL_ID
C063101	MESH_SUPPLEMENTAL_RECORD_UI
3E6IB3P0LT	UNII
16154789	PUBCHEM_CID

Pharmaceutical products:

None