tandospirone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anxiolytics, buspirone derivatives 2563 87760-53-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tandospirone
  • tandospirone citrate
  • metanopirone citrate
  • Molecular weight: 383.50
  • Formula: C21H29N5O2
  • CLOGP: 1.90
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 69.64
  • ALOGS: -2.54
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017366 Serotonin Receptor Agonists
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35469 thymoanaleptics
CHEBI has role CHEBI:35474 minor tranquilisers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bruxism (teeth grinding) indication 191983006 DOID:2846

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.82 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 1A GPCR Ki 7.49 CHEMBL
D(2) dopamine receptor GPCR Ki 7.55 CHEMBL
D(4) dopamine receptor GPCR Ki 8.14 CHEMBL

External reference:

IDSource
D01992 KEGG_DRUG
112457-95-1 SECONDARY_CAS_RN
C0074676 UMLSCUI
CHEBI:32182 CHEBI
CHEMBL274047 ChEMBL_ID
CHEMBL1628275 ChEMBL_ID
CHEMBL2103888 ChEMBL_ID
C055267 MESH_SUPPLEMENTAL_RECORD_UI
6332 INN_ID
DB12833 DRUGBANK_ID
190230I669 UNII
60558 PUBCHEM_CID
55 IUPHAR_LIGAND_ID

Pharmaceutical products:

None