taltirelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
thyrotropin releasing hormone analogues	2560	103300-74-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

taltirelin hydrate
ceredist
taltirelin tetrahydrate
TA-0910
TA 0910
taltirelin

Molecular weight: 405.42
Formula: C17H23N7O5
CLOGP: -1.40
LIPINSKI: 1
HAC: 12
HDO: 4
TPSA: 170.59
ALOGS: -2.17
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018697	Nootropic Agents
CHEBI has role	CHEBI:63726	neuroprotective agents
CHEBI has role	CHEBI:66980	intelligence enhancer
CHEBI has role	CHEBI:35470	central nervous system agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Spinocerebellar disease	indication	91502009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.29	acidic
pKa2	13.15	acidic
pKa3	13.8	acidic
pKa4	7.55	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Thyrotropin-releasing hormone receptor	GPCR	P34981	TRFR_HUMAN	AGONIST	Ki	6.50		IUPHAR	SCIENTIFIC LITERATURE

External reference:

ID	Source
D01925	KEGG_DRUG
201677-75-0	SECONDARY_CAS_RN
C2960839	UMLSCUI
CHEBI:135653	CHEBI
CHEMBL2107016	ChEMBL_ID
C065049	MESH_SUPPLEMENTAL_RECORD_UI
114750	PUBCHEM_CID
2143	IUPHAR_LIGAND_ID
7503	INN_ID
DOZ62MV6A5	UNII

Pharmaceutical products:

None