Stem definition | Drug id | CAS RN |
---|---|---|
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 256 | 83015-26-3 |
Dose | Unit | Route |
---|---|---|
80 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 27.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.39 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.85 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 9.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 26, 2002 | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Suicidal ideation | 225.16 | 19.40 | 134 | 8963 | 55251 | 50540776 |
Prescribed overdose | 149.68 | 19.40 | 66 | 9031 | 14534 | 50581493 |
Tic | 112.99 | 19.40 | 29 | 9068 | 1188 | 50594839 |
Irritability | 108.17 | 19.40 | 66 | 9031 | 28360 | 50567667 |
Blepharospasm | 108.08 | 19.40 | 34 | 9063 | 2914 | 50593113 |
Aggression | 106.84 | 19.40 | 59 | 9038 | 21057 | 50574970 |
Abnormal behaviour | 102.41 | 19.40 | 56 | 9041 | 19602 | 50576425 |
Crying | 74.08 | 19.40 | 46 | 9051 | 20370 | 50575657 |
Agitation | 72.98 | 19.40 | 67 | 9030 | 53317 | 50542710 |
Myocarditis | 72.10 | 19.40 | 33 | 9064 | 7914 | 50588113 |
Tachycardia | 71.79 | 19.40 | 89 | 9008 | 99674 | 50496353 |
Suicide attempt | 66.99 | 19.40 | 63 | 9034 | 51669 | 50544358 |
Depression | 66.64 | 19.40 | 112 | 8985 | 165311 | 50430716 |
Disturbance in attention | 65.12 | 19.40 | 50 | 9047 | 31136 | 50564891 |
Intentional self-injury | 64.08 | 19.40 | 44 | 9053 | 23068 | 50572959 |
Taste disorder | 61.49 | 19.40 | 30 | 9067 | 8294 | 50587733 |
Attention deficit hyperactivity disorder | 60.80 | 19.40 | 21 | 9076 | 2408 | 50593619 |
Overdose | 56.30 | 19.40 | 79 | 9018 | 99648 | 50496379 |
Somnolence | 50.88 | 19.40 | 96 | 9001 | 154889 | 50441138 |
Impulsive behaviour | 50.06 | 19.40 | 16 | 9081 | 1442 | 50594585 |
Epilepsy | 48.16 | 19.40 | 36 | 9061 | 21531 | 50574496 |
Mood swings | 45.70 | 19.40 | 31 | 9066 | 15923 | 50580104 |
Raynaud's phenomenon | 44.93 | 19.40 | 14 | 9083 | 1162 | 50594865 |
Anxiety | 44.08 | 19.40 | 98 | 8999 | 177508 | 50418519 |
Intentional overdose | 43.69 | 19.40 | 55 | 9042 | 62449 | 50533578 |
Psychomotor hyperactivity | 41.64 | 19.40 | 24 | 9073 | 9277 | 50586750 |
Seizure | 41.15 | 19.40 | 75 | 9022 | 117799 | 50478228 |
Loss of consciousness | 41.08 | 19.40 | 70 | 9027 | 104283 | 50491744 |
Mania | 40.61 | 19.40 | 25 | 9072 | 10891 | 50585136 |
Trichotillomania | 38.96 | 19.40 | 8 | 9089 | 118 | 50595909 |
Liver injury | 37.56 | 19.40 | 33 | 9064 | 24773 | 50571254 |
Supine hypertension | 37.47 | 19.40 | 7 | 9090 | 61 | 50595966 |
Anger | 37.26 | 19.40 | 24 | 9073 | 11309 | 50584718 |
Electrocardiogram QT prolonged | 35.22 | 19.40 | 45 | 9052 | 51841 | 50544186 |
Psychotic disorder | 35.00 | 19.40 | 30 | 9067 | 21782 | 50574245 |
Memory impairment | 34.94 | 19.40 | 56 | 9041 | 79304 | 50516723 |
Dystonia | 33.74 | 19.40 | 23 | 9074 | 11903 | 50584124 |
Bipolar I disorder | 33.68 | 19.40 | 12 | 9085 | 1506 | 50594521 |
Oppositional defiant disorder | 33.53 | 19.40 | 6 | 9091 | 40 | 50595987 |
Aspartate aminotransferase increased | 32.92 | 19.40 | 54 | 9043 | 77944 | 50518083 |
Obsessive-compulsive disorder | 30.70 | 19.40 | 14 | 9083 | 3326 | 50592701 |
Paraesthesia | 30.53 | 19.40 | 67 | 9030 | 120176 | 50475851 |
Drug screen positive | 30.45 | 19.40 | 14 | 9083 | 3388 | 50592639 |
Educational problem | 30.20 | 19.40 | 8 | 9089 | 371 | 50595656 |
Renal tubular acidosis | 29.83 | 19.40 | 11 | 9086 | 1523 | 50594504 |
Product tampering | 29.60 | 19.40 | 7 | 9090 | 203 | 50595824 |
Mydriasis | 28.90 | 19.40 | 20 | 9077 | 10607 | 50585420 |
Feeling abnormal | 28.60 | 19.40 | 67 | 9030 | 125425 | 50470602 |
Completed suicide | 28.53 | 19.40 | 69 | 9028 | 131820 | 50464207 |
Gastrooesophageal reflux disease | 28.40 | 19.40 | 50 | 9047 | 76378 | 50519649 |
Heart rate increased | 28.01 | 19.40 | 50 | 9047 | 77200 | 50518827 |
Pulse abnormal | 27.86 | 19.40 | 11 | 9086 | 1834 | 50594193 |
Hypomania | 26.72 | 19.40 | 14 | 9083 | 4491 | 50591536 |
Piloerection | 26.54 | 19.40 | 7 | 9090 | 319 | 50595708 |
Thinking abnormal | 26.00 | 19.40 | 18 | 9079 | 9549 | 50586478 |
Diarrhoea | 25.22 | 19.40 | 42 | 9055 | 588434 | 50007593 |
Congestive hepatopathy | 24.66 | 19.40 | 11 | 9086 | 2483 | 50593544 |
Dysmenorrhoea | 24.65 | 19.40 | 12 | 9085 | 3298 | 50592729 |
Mood altered | 23.46 | 19.40 | 19 | 9078 | 12754 | 50583273 |
Social avoidant behaviour | 23.45 | 19.40 | 11 | 9086 | 2786 | 50593241 |
Alanine aminotransferase increased | 23.28 | 19.40 | 50 | 9047 | 88309 | 50507718 |
Emotional disorder | 22.58 | 19.40 | 18 | 9079 | 11818 | 50584209 |
Pneumonia | 22.46 | 19.40 | 21 | 9076 | 378380 | 50217647 |
Palpitations | 22.12 | 19.40 | 51 | 9046 | 94455 | 50501572 |
Hypoaesthesia | 21.78 | 19.40 | 61 | 9036 | 127196 | 50468831 |
Hyperhidrosis | 21.75 | 19.40 | 49 | 9048 | 89377 | 50506650 |
Bipolar disorder | 21.45 | 19.40 | 14 | 9083 | 6743 | 50589284 |
Personality change | 21.18 | 19.40 | 13 | 9084 | 5632 | 50590395 |
Hepatitis | 20.89 | 19.40 | 27 | 9070 | 31426 | 50564601 |
Joint swelling | 20.86 | 19.40 | 9 | 9088 | 245277 | 50350750 |
Peripheral swelling | 20.16 | 19.40 | 6 | 9091 | 205930 | 50390097 |
Insomnia | 20.04 | 19.40 | 73 | 9024 | 174792 | 50421235 |
Acute kidney injury | 19.98 | 19.40 | 8 | 9089 | 228050 | 50367977 |
Merycism | 19.94 | 19.40 | 5 | 9092 | 186 | 50595841 |
Generalised tonic-clonic seizure | 19.73 | 19.40 | 24 | 9073 | 26286 | 50569741 |
Abnormal dreams | 19.48 | 19.40 | 15 | 9082 | 9362 | 50586665 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Suicidal ideation | 665.28 | 23.15 | 328 | 14058 | 34388 | 29525753 |
Tic | 559.19 | 23.15 | 138 | 14248 | 1697 | 29558444 |
Aggression | 527.86 | 23.15 | 283 | 14103 | 35258 | 29524883 |
Prescribed overdose | 485.69 | 23.15 | 176 | 14210 | 8507 | 29551634 |
Abnormal behaviour | 342.50 | 23.15 | 184 | 14202 | 22943 | 29537198 |
Anger | 260.19 | 23.15 | 120 | 14266 | 10770 | 29549371 |
Irritability | 238.12 | 23.15 | 143 | 14243 | 22009 | 29538132 |
Crying | 203.73 | 23.15 | 82 | 14304 | 5269 | 29554872 |
Intentional self-injury | 195.17 | 23.15 | 103 | 14283 | 12358 | 29547783 |
Testicular pain | 175.05 | 23.15 | 60 | 14326 | 2449 | 29557692 |
Psychomotor hyperactivity | 166.96 | 23.15 | 81 | 14305 | 8132 | 29552009 |
Oppositional defiant disorder | 146.99 | 23.15 | 37 | 14349 | 494 | 29559647 |
Ejaculation disorder | 142.67 | 23.15 | 41 | 14345 | 927 | 29559214 |
Agitation | 130.33 | 23.15 | 142 | 14244 | 51162 | 29508979 |
Homicidal ideation | 129.27 | 23.15 | 48 | 14338 | 2476 | 29557665 |
Mood swings | 128.06 | 23.15 | 65 | 14321 | 7186 | 29552955 |
Urinary hesitation | 127.87 | 23.15 | 46 | 14340 | 2167 | 29557974 |
Suicide attempt | 118.78 | 23.15 | 112 | 14274 | 33998 | 29526143 |
Disturbance in attention | 112.52 | 23.15 | 89 | 14297 | 21335 | 29538806 |
Anxiety | 111.72 | 23.15 | 170 | 14216 | 85195 | 29474946 |
Impulsive behaviour | 110.81 | 23.15 | 40 | 14346 | 1903 | 29558238 |
Heart rate increased | 106.29 | 23.15 | 112 | 14274 | 38826 | 29521315 |
Depressed mood | 105.52 | 23.15 | 77 | 14309 | 16371 | 29543770 |
Acute kidney injury | 99.30 | 23.15 | 8 | 14378 | 265259 | 29294882 |
Pneumonia | 97.43 | 23.15 | 19 | 14367 | 320153 | 29239988 |
Death | 96.64 | 23.15 | 24 | 14362 | 342060 | 29218081 |
Mood altered | 93.95 | 23.15 | 55 | 14331 | 8056 | 29552085 |
Depression | 92.75 | 23.15 | 156 | 14230 | 84991 | 29475150 |
Attention deficit hyperactivity disorder | 91.41 | 23.15 | 36 | 14350 | 2181 | 29557960 |
Insomnia | 90.61 | 23.15 | 158 | 14228 | 88603 | 29471538 |
Hallucination, auditory | 90.41 | 23.15 | 57 | 14329 | 9536 | 29550605 |
Somnolence | 87.91 | 23.15 | 161 | 14225 | 93794 | 29466347 |
Decreased eye contact | 87.19 | 23.15 | 24 | 14362 | 461 | 29559680 |
Bruxism | 84.28 | 23.15 | 31 | 14355 | 1556 | 29558585 |
Drug screen positive | 81.81 | 23.15 | 39 | 14347 | 3762 | 29556379 |
Palpitations | 77.12 | 23.15 | 87 | 14299 | 32517 | 29527624 |
Product substitution issue | 75.36 | 23.15 | 50 | 14336 | 9122 | 29551019 |
Psychotic disorder | 74.99 | 23.15 | 69 | 14317 | 20285 | 29539856 |
Mania | 73.06 | 23.15 | 48 | 14338 | 8615 | 29551526 |
Alanine aminotransferase increased | 70.68 | 23.15 | 125 | 14261 | 70819 | 29489322 |
Self-injurious ideation | 70.37 | 23.15 | 27 | 14359 | 1524 | 29558617 |
Mydriasis | 69.78 | 23.15 | 41 | 14345 | 6044 | 29554097 |
Feeling abnormal | 69.11 | 23.15 | 107 | 14279 | 54338 | 29505803 |
Tachycardia | 67.56 | 23.15 | 124 | 14262 | 72286 | 29487855 |
Aspartate aminotransferase increased | 64.40 | 23.15 | 109 | 14277 | 59616 | 29500525 |
Seizure | 63.58 | 23.15 | 140 | 14246 | 92983 | 29467158 |
Dystonia | 63.32 | 23.15 | 46 | 14340 | 9703 | 29550438 |
Educational problem | 63.08 | 23.15 | 19 | 14367 | 508 | 29559633 |
Suicidal behaviour | 62.78 | 23.15 | 24 | 14362 | 1341 | 29558800 |
Dysuria | 60.21 | 23.15 | 64 | 14322 | 22376 | 29537765 |
Penile discharge | 59.68 | 23.15 | 12 | 14374 | 51 | 29560090 |
Sepsis | 57.14 | 23.15 | 3 | 14383 | 142679 | 29417462 |
Anaemia | 56.79 | 23.15 | 14 | 14372 | 200937 | 29359204 |
Diarrhoea | 55.95 | 23.15 | 48 | 14338 | 332650 | 29227491 |
Electrocardiogram QT prolonged | 55.93 | 23.15 | 78 | 14308 | 36059 | 29524082 |
Dyskinesia | 55.21 | 23.15 | 58 | 14328 | 20003 | 29540138 |
Choreoathetosis | 54.44 | 23.15 | 20 | 14366 | 1000 | 29559141 |
Blood alkaline phosphatase increased | 54.28 | 23.15 | 68 | 14318 | 28338 | 29531803 |
Nervousness | 53.05 | 23.15 | 44 | 14342 | 11262 | 29548879 |
Retching | 52.57 | 23.15 | 34 | 14352 | 5939 | 29554202 |
Emotional disorder | 50.76 | 23.15 | 31 | 14355 | 4900 | 29555241 |
Trismus | 46.99 | 23.15 | 23 | 14363 | 2350 | 29557791 |
Headache | 46.24 | 23.15 | 187 | 14199 | 173820 | 29386321 |
Generalised tonic-clonic seizure | 43.42 | 23.15 | 50 | 14336 | 19089 | 29541052 |
Affect lability | 41.86 | 23.15 | 24 | 14362 | 3378 | 29556763 |
Gilbert's syndrome | 40.80 | 23.15 | 8 | 14378 | 29 | 29560112 |
Coordination abnormal | 40.46 | 23.15 | 31 | 14355 | 7083 | 29553058 |
Febrile neutropenia | 40.23 | 23.15 | 4 | 14382 | 112236 | 29447905 |
Screaming | 39.98 | 23.15 | 17 | 14369 | 1253 | 29558888 |
Social avoidant behaviour | 39.56 | 23.15 | 22 | 14364 | 2920 | 29557221 |
Growth retardation | 38.94 | 23.15 | 18 | 14368 | 1618 | 29558523 |
Panic attack | 38.22 | 23.15 | 32 | 14354 | 8294 | 29551847 |
Sexual dysfunction | 36.77 | 23.15 | 27 | 14359 | 5787 | 29554354 |
Blood bilirubin increased | 36.68 | 23.15 | 62 | 14324 | 33831 | 29526310 |
General physical health deterioration | 36.00 | 23.15 | 4 | 14382 | 102853 | 29457288 |
Tearfulness | 35.85 | 23.15 | 17 | 14369 | 1619 | 29558522 |
Paranoia | 35.42 | 23.15 | 33 | 14353 | 9844 | 29550297 |
Trichotillomania | 35.38 | 23.15 | 8 | 14378 | 65 | 29560076 |
Loss of consciousness | 35.24 | 23.15 | 97 | 14289 | 73959 | 29486182 |
Thrombocytopenia | 35.05 | 23.15 | 11 | 14375 | 134812 | 29425329 |
Thinking abnormal | 34.66 | 23.15 | 25 | 14361 | 5211 | 29554930 |
Hepatic enzyme increased | 34.18 | 23.15 | 60 | 14326 | 33739 | 29526402 |
Personality change | 32.67 | 23.15 | 23 | 14363 | 4615 | 29555526 |
Physical assault | 32.44 | 23.15 | 14 | 14372 | 1070 | 29559071 |
Renal failure | 32.05 | 23.15 | 9 | 14377 | 118590 | 29441551 |
Enuresis | 31.96 | 23.15 | 17 | 14369 | 2067 | 29558074 |
Pallor | 31.94 | 23.15 | 45 | 14341 | 20979 | 29539162 |
Abdominal pain upper | 31.13 | 23.15 | 82 | 14304 | 60911 | 29499230 |
Apathy | 31.01 | 23.15 | 25 | 14361 | 6146 | 29553995 |
Sleep disorder | 31.00 | 23.15 | 48 | 14338 | 24338 | 29535803 |
Fight in school | 30.80 | 23.15 | 5 | 14381 | 3 | 29560138 |
Obsessive-compulsive disorder | 30.64 | 23.15 | 22 | 14364 | 4554 | 29555587 |
Negativism | 30.23 | 23.15 | 10 | 14376 | 365 | 29559776 |
Hyperkinesia | 30.18 | 23.15 | 15 | 14371 | 1584 | 29558557 |
Scrotal pain | 29.60 | 23.15 | 12 | 14374 | 784 | 29559357 |
Erectile dysfunction | 29.54 | 23.15 | 40 | 14346 | 17969 | 29542172 |
Respiratory failure | 28.93 | 23.15 | 6 | 14380 | 97125 | 29463016 |
Repetitive speech | 28.80 | 23.15 | 7 | 14379 | 80 | 29560061 |
Cardiac failure | 27.95 | 23.15 | 3 | 14383 | 79284 | 29480857 |
Syncope | 27.86 | 23.15 | 95 | 14291 | 81276 | 29478865 |
Pyrexia | 27.66 | 23.15 | 62 | 14324 | 287560 | 29272581 |
Hyperhidrosis | 27.25 | 23.15 | 81 | 14305 | 64459 | 29495682 |
Decreased appetite | 27.21 | 23.15 | 141 | 14245 | 145201 | 29414940 |
Urinary retention | 26.45 | 23.15 | 52 | 14334 | 31846 | 29528295 |
Pyromania | 26.29 | 23.15 | 6 | 14380 | 51 | 29560090 |
Abdominal discomfort | 26.08 | 23.15 | 66 | 14320 | 47837 | 29512304 |
Hostility | 25.93 | 23.15 | 11 | 14375 | 806 | 29559335 |
Speech disorder | 25.41 | 23.15 | 43 | 14343 | 23473 | 29536668 |
Dyspnoea | 24.93 | 23.15 | 79 | 14307 | 326653 | 29233488 |
Chest pain | 24.79 | 23.15 | 114 | 14272 | 111859 | 29448282 |
Amphetamines positive | 24.71 | 23.15 | 7 | 14379 | 150 | 29559991 |
Raynaud's phenomenon | 24.50 | 23.15 | 8 | 14378 | 280 | 29559861 |
Asthenia | 24.48 | 23.15 | 42 | 14344 | 215208 | 29344933 |
Tourette's disorder | 24.42 | 23.15 | 6 | 14380 | 72 | 29560069 |
Dysphoria | 23.73 | 23.15 | 14 | 14372 | 2078 | 29558063 |
Vomiting | 23.50 | 23.15 | 180 | 14206 | 212080 | 29348061 |
Sedation | 23.17 | 23.15 | 35 | 14351 | 17370 | 29542771 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Suicidal ideation | 705.04 | 18.15 | 362 | 19268 | 66180 | 64412922 |
Tic | 684.45 | 18.15 | 159 | 19471 | 2460 | 64476642 |
Prescribed overdose | 598.18 | 18.15 | 227 | 19403 | 20104 | 64458998 |
Aggression | 561.29 | 18.15 | 276 | 19354 | 45956 | 64433146 |
Abnormal behaviour | 402.72 | 18.15 | 199 | 19431 | 33423 | 64445679 |
Irritability | 318.18 | 18.15 | 175 | 19455 | 36571 | 64442531 |
Anger | 297.70 | 18.15 | 128 | 19502 | 15613 | 64463489 |
Psychomotor hyperactivity | 242.38 | 18.15 | 108 | 19522 | 14343 | 64464759 |
Crying | 211.38 | 18.15 | 109 | 19521 | 19981 | 64459121 |
Intentional self-injury | 202.15 | 18.15 | 120 | 19510 | 28924 | 64450178 |
Oppositional defiant disorder | 178.60 | 18.15 | 39 | 19591 | 447 | 64478655 |
Agitation | 172.73 | 18.15 | 171 | 19459 | 88196 | 64390906 |
Disturbance in attention | 164.20 | 18.15 | 120 | 19510 | 40954 | 64438148 |
Mood swings | 158.87 | 18.15 | 86 | 19544 | 17382 | 64461720 |
Ejaculation disorder | 149.55 | 18.15 | 34 | 19596 | 474 | 64478628 |
Suicide attempt | 145.43 | 18.15 | 141 | 19489 | 70866 | 64408236 |
Homicidal ideation | 143.18 | 18.15 | 49 | 19581 | 3208 | 64475894 |
Impulsive behaviour | 132.61 | 18.15 | 44 | 19586 | 2619 | 64476483 |
Anxiety | 131.17 | 18.15 | 227 | 19403 | 202422 | 64276680 |
Depression | 130.15 | 18.15 | 214 | 19416 | 183077 | 64296025 |
Testicular pain | 128.80 | 18.15 | 39 | 19591 | 1721 | 64477381 |
Mania | 115.14 | 18.15 | 68 | 19562 | 16218 | 64462884 |
Attention deficit hyperactivity disorder | 111.42 | 18.15 | 39 | 19591 | 2731 | 64476371 |
Somnolence | 111.27 | 18.15 | 212 | 19418 | 203433 | 64275669 |
Urinary hesitation | 109.66 | 18.15 | 41 | 19589 | 3469 | 64475633 |
Heart rate increased | 108.96 | 18.15 | 142 | 19488 | 98533 | 64380569 |
Educational problem | 108.01 | 18.15 | 25 | 19605 | 379 | 64478723 |
Tachycardia | 107.96 | 18.15 | 176 | 19454 | 149403 | 64329699 |
Seizure | 96.42 | 18.15 | 178 | 19452 | 166714 | 64312388 |
Acute kidney injury | 95.93 | 18.15 | 12 | 19618 | 449228 | 64029874 |
Dystonia | 93.74 | 18.15 | 63 | 19567 | 18802 | 64460300 |
Hallucination, auditory | 92.49 | 18.15 | 60 | 19570 | 16879 | 64462223 |
Decreased eye contact | 92.16 | 18.15 | 25 | 19605 | 740 | 64478362 |
Aspartate aminotransferase increased | 90.56 | 18.15 | 144 | 19486 | 119644 | 64359458 |
Product substitution issue | 89.59 | 18.15 | 60 | 19570 | 17801 | 64461301 |
Blepharospasm | 89.56 | 18.15 | 35 | 19595 | 3340 | 64475762 |
Insomnia | 87.83 | 18.15 | 189 | 19441 | 197647 | 64281455 |
Alanine aminotransferase increased | 84.99 | 18.15 | 152 | 19478 | 138879 | 64340223 |
Pneumonia | 83.63 | 18.15 | 33 | 19597 | 559543 | 63919559 |
Psychotic disorder | 80.96 | 18.15 | 74 | 19556 | 34504 | 64444598 |
Trichotillomania | 80.51 | 18.15 | 17 | 19613 | 164 | 64478938 |
Depressed mood | 79.36 | 18.15 | 79 | 19551 | 40933 | 64438169 |
Mood altered | 78.52 | 18.15 | 53 | 19577 | 15926 | 64463176 |
Feeling abnormal | 75.25 | 18.15 | 141 | 19489 | 133461 | 64345641 |
Bruxism | 73.54 | 18.15 | 31 | 19599 | 3593 | 64475509 |
Mydriasis | 73.36 | 18.15 | 50 | 19580 | 15262 | 64463840 |
Dyskinesia | 70.96 | 18.15 | 73 | 19557 | 39315 | 64439787 |
Electrocardiogram QT prolonged | 69.16 | 18.15 | 102 | 19528 | 79346 | 64399756 |
Self-injurious ideation | 67.06 | 18.15 | 28 | 19602 | 3169 | 64475933 |
Obsessive-compulsive disorder | 65.08 | 18.15 | 31 | 19599 | 4787 | 64474315 |
Drug screen positive | 62.88 | 18.15 | 32 | 19598 | 5697 | 64473405 |
Diarrhoea | 62.66 | 18.15 | 77 | 19553 | 722627 | 63756475 |
Death | 62.02 | 18.15 | 35 | 19595 | 482670 | 63996432 |
Generalised tonic-clonic seizure | 61.43 | 18.15 | 68 | 19562 | 39789 | 64439313 |
Loss of consciousness | 59.31 | 18.15 | 136 | 19494 | 148229 | 64330873 |
Emotional disorder | 57.64 | 18.15 | 40 | 19590 | 12567 | 64466535 |
Retching | 57.39 | 18.15 | 43 | 19587 | 15213 | 64463889 |
Palpitations | 57.23 | 18.15 | 109 | 19521 | 104379 | 64374723 |
Anaemia | 57.04 | 18.15 | 22 | 19608 | 378658 | 64100444 |
Choreoathetosis | 56.77 | 18.15 | 20 | 19610 | 1427 | 64477675 |
Suicidal behaviour | 56.27 | 18.15 | 24 | 19606 | 2863 | 64476239 |
Social avoidant behaviour | 54.56 | 18.15 | 27 | 19603 | 4530 | 64474572 |
Nervousness | 51.83 | 18.15 | 54 | 19576 | 29502 | 64449600 |
Growth retardation | 51.57 | 18.15 | 19 | 19611 | 1542 | 64477560 |
Blood alkaline phosphatase increased | 51.50 | 18.15 | 74 | 19556 | 56205 | 64422897 |
Penile discharge | 50.47 | 18.15 | 9 | 19621 | 31 | 64479071 |
Sepsis | 49.46 | 18.15 | 6 | 19624 | 230335 | 64248767 |
Bipolar I disorder | 49.24 | 18.15 | 19 | 19611 | 1752 | 64477350 |
Personality change | 48.29 | 18.15 | 31 | 19599 | 8562 | 64470540 |
Affect lability | 47.01 | 18.15 | 31 | 19599 | 8959 | 64470143 |
Hyperhidrosis | 45.02 | 18.15 | 110 | 19520 | 124810 | 64354292 |
Thinking abnormal | 44.42 | 18.15 | 33 | 19597 | 11523 | 64467579 |
Paranoia | 44.25 | 18.15 | 38 | 19592 | 16314 | 64462788 |
Peripheral swelling | 43.57 | 18.15 | 6 | 19624 | 209147 | 64269955 |
Nightmare | 43.51 | 18.15 | 42 | 19588 | 20951 | 64458151 |
Coordination abnormal | 43.01 | 18.15 | 36 | 19594 | 14928 | 64464174 |
Febrile neutropenia | 40.00 | 18.15 | 5 | 19625 | 187652 | 64291450 |
Intentional overdose | 39.91 | 18.15 | 86 | 19544 | 89858 | 64389244 |
Trismus | 38.71 | 18.15 | 22 | 19608 | 4879 | 64474223 |
Taste disorder | 38.66 | 18.15 | 28 | 19602 | 9405 | 64469697 |
Gilbert's syndrome | 38.43 | 18.15 | 7 | 19623 | 28 | 64479074 |
Epilepsy | 38.12 | 18.15 | 49 | 19581 | 33482 | 64445620 |
General physical health deterioration | 37.88 | 18.15 | 8 | 19622 | 204417 | 64274685 |
Scrotal pain | 37.46 | 18.15 | 11 | 19619 | 436 | 64478666 |
Physical assault | 37.41 | 18.15 | 15 | 19615 | 1531 | 64477571 |
Thrombocytopenia | 37.14 | 18.15 | 11 | 19619 | 223790 | 64255312 |
Dysuria | 36.58 | 18.15 | 54 | 19576 | 42003 | 64437099 |
Overdose | 36.34 | 18.15 | 119 | 19511 | 159447 | 64319655 |
Arthralgia | 35.27 | 18.15 | 50 | 19580 | 442210 | 64036892 |
Speech disorder | 34.87 | 18.15 | 57 | 19573 | 48384 | 64430718 |
Enuresis | 34.80 | 18.15 | 17 | 19613 | 2773 | 64476329 |
Joint swelling | 33.25 | 18.15 | 12 | 19618 | 215370 | 64263732 |
Hyperkinesia | 33.22 | 18.15 | 16 | 19614 | 2530 | 64476572 |
Pancytopenia | 32.63 | 18.15 | 3 | 19627 | 143306 | 64335796 |
Decreased appetite | 32.41 | 18.15 | 170 | 19460 | 281119 | 64197983 |
Raynaud's phenomenon | 32.22 | 18.15 | 12 | 19618 | 1004 | 64478098 |
Bipolar disorder | 32.20 | 18.15 | 22 | 19608 | 6739 | 64472363 |
Tourette's disorder | 32.15 | 18.15 | 7 | 19623 | 79 | 64479023 |
School refusal | 31.85 | 18.15 | 6 | 19624 | 30 | 64479072 |
Blood bilirubin increased | 31.44 | 18.15 | 60 | 19570 | 57493 | 64421609 |
Rheumatoid arthritis | 31.33 | 18.15 | 6 | 19624 | 164288 | 64314814 |
Sleep disorder | 31.09 | 18.15 | 61 | 19569 | 59648 | 64419454 |
Panic attack | 30.99 | 18.15 | 35 | 19595 | 20918 | 64458184 |
Infection | 30.83 | 18.15 | 9 | 19621 | 184871 | 64294231 |
Petit mal epilepsy | 30.39 | 18.15 | 19 | 19611 | 5013 | 64474089 |
Dyspnoea | 29.43 | 18.15 | 116 | 19514 | 718558 | 63760544 |
Tearfulness | 29.12 | 18.15 | 18 | 19612 | 4655 | 64474447 |
Pain in extremity | 28.65 | 18.15 | 30 | 19600 | 303055 | 64176047 |
Renal failure | 28.25 | 18.15 | 10 | 19620 | 181678 | 64297424 |
Infusion related reaction | 27.43 | 18.15 | 8 | 19622 | 164459 | 64314643 |
Feeling jittery | 27.33 | 18.15 | 24 | 19606 | 10611 | 64468491 |
Hyponatraemia | 27.08 | 18.15 | 6 | 19624 | 148333 | 64330769 |
Abdominal pain upper | 26.87 | 18.15 | 115 | 19515 | 174915 | 64304187 |
Headache | 26.75 | 18.15 | 262 | 19368 | 529205 | 63949897 |
Pyromania | 26.71 | 18.15 | 5 | 19625 | 24 | 64479078 |
Viral infection | 26.65 | 18.15 | 43 | 19587 | 36097 | 64443005 |
Pyrexia | 26.28 | 18.15 | 85 | 19545 | 558559 | 63920543 |
Hostility | 26.19 | 18.15 | 13 | 19617 | 2194 | 64476908 |
Sedation | 26.15 | 18.15 | 46 | 19584 | 41416 | 64437686 |
Myocarditis | 26.12 | 18.15 | 29 | 19601 | 17014 | 64462088 |
Completed suicide | 26.09 | 18.15 | 136 | 19494 | 224278 | 64254824 |
Chest pain | 26.06 | 18.15 | 141 | 19489 | 235839 | 64243263 |
Hypomania | 25.98 | 18.15 | 18 | 19612 | 5636 | 64473466 |
Erectile dysfunction | 25.67 | 18.15 | 25 | 19605 | 12602 | 64466500 |
Screaming | 25.63 | 18.15 | 15 | 19615 | 3514 | 64475588 |
Product tampering | 25.58 | 18.15 | 7 | 19623 | 214 | 64478888 |
Neuropathy peripheral | 25.36 | 18.15 | 3 | 19627 | 117522 | 64361580 |
Urinary retention | 25.29 | 18.15 | 50 | 19580 | 49151 | 64429951 |
Staring | 25.11 | 18.15 | 13 | 19617 | 2397 | 64476705 |
Pain | 24.81 | 18.15 | 86 | 19544 | 553425 | 63925677 |
Cardiac failure congestive | 24.41 | 18.15 | 5 | 19625 | 130575 | 64348527 |
Fall | 24.38 | 18.15 | 57 | 19573 | 416769 | 64062333 |
Apathy | 24.27 | 18.15 | 23 | 19607 | 11209 | 64467893 |
Negativism | 24.18 | 18.15 | 9 | 19621 | 751 | 64478351 |
Restlessness | 23.63 | 18.15 | 43 | 19587 | 39742 | 64439360 |
Renal impairment | 23.58 | 18.15 | 6 | 19624 | 135011 | 64344091 |
Euphoric mood | 23.51 | 18.15 | 18 | 19612 | 6573 | 64472529 |
Vomiting | 23.26 | 18.15 | 263 | 19367 | 550854 | 63928248 |
Hypotension | 23.17 | 18.15 | 51 | 19579 | 380923 | 64098179 |
Infectious mononucleosis | 22.94 | 18.15 | 11 | 19619 | 1722 | 64477380 |
Drooling | 22.28 | 18.15 | 16 | 19614 | 5303 | 64473799 |
Supine hypertension | 22.19 | 18.15 | 7 | 19623 | 354 | 64478748 |
Dysphemia | 21.97 | 18.15 | 13 | 19617 | 3106 | 64475996 |
Cyanosis | 21.54 | 18.15 | 30 | 19600 | 22125 | 64456977 |
Gastrointestinal haemorrhage | 21.05 | 18.15 | 7 | 19623 | 132305 | 64346797 |
Treatment noncompliance | 20.93 | 18.15 | 43 | 19587 | 43439 | 64435663 |
Drug hypersensitivity | 20.86 | 18.15 | 25 | 19605 | 237790 | 64241312 |
Rash | 20.70 | 18.15 | 71 | 19559 | 458478 | 64020624 |
Pallor | 20.65 | 18.15 | 40 | 19590 | 38741 | 64440361 |
Contraindicated product administered | 20.42 | 18.15 | 4 | 19626 | 107825 | 64371277 |
Dysphoria | 20.24 | 18.15 | 14 | 19616 | 4374 | 64474728 |
Prostatic pain | 20.21 | 18.15 | 4 | 19626 | 27 | 64479075 |
Medication error | 20.15 | 18.15 | 46 | 19584 | 49920 | 64429182 |
Syncope | 20.04 | 18.15 | 98 | 19532 | 157537 | 64321565 |
Hallucination | 20.01 | 18.15 | 58 | 19572 | 72730 | 64406372 |
Wolff-Parkinson-White syndrome | 19.96 | 18.15 | 6 | 19624 | 258 | 64478844 |
Chromaturia | 19.61 | 18.15 | 29 | 19601 | 22582 | 64456520 |
Streptococcal infection | 19.46 | 18.15 | 17 | 19613 | 7462 | 64471640 |
Drug abuse | 19.38 | 18.15 | 8 | 19622 | 132366 | 64346736 |
Sinus tachycardia | 19.38 | 18.15 | 35 | 19595 | 32153 | 64446949 |
Penile pain | 19.31 | 18.15 | 8 | 19622 | 887 | 64478215 |
Fight in school | 19.22 | 18.15 | 3 | 19627 | 3 | 64479099 |
Male genital atrophy | 19.22 | 18.15 | 3 | 19627 | 3 | 64479099 |
Peripheral coldness | 18.92 | 18.15 | 22 | 19608 | 13562 | 64465540 |
Stomatitis | 18.89 | 18.15 | 5 | 19625 | 109600 | 64369502 |
Haemoglobin decreased | 18.76 | 18.15 | 19 | 19611 | 195044 | 64284058 |
Gastric hypomotility | 18.73 | 18.15 | 5 | 19625 | 139 | 64478963 |
Blood creatinine increased | 18.63 | 18.15 | 9 | 19621 | 135773 | 64343329 |
Distractibility | 18.21 | 18.15 | 7 | 19623 | 639 | 64478463 |
Pulmonary embolism | 18.19 | 18.15 | 11 | 19619 | 146345 | 64332757 |
None
Source | Code | Description |
---|---|---|
ATC | N06BA09 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics |
FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
FDA EPC | N0000175695 | Norepinephrine Reuptake Inhibitor |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Attention deficit hyperactivity disorder | indication | 406506008 | |
Delay when starting to pass urine | contraindication | 5972002 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Suicidal thoughts | contraindication | 6471006 | |
Sinus tachycardia | contraindication | 11092001 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Feeling agitated | contraindication | 24199005 | |
Orthostatic hypotension | contraindication | 28651003 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Feeling irritable | contraindication | 55929007 | |
Aggressive behavior | contraindication | 61372001 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Psychotic disorder | contraindication | 69322001 | |
Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
Structural disorder of heart | contraindication | 128599005 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Cerebrovascular accident | contraindication | 230690007 | |
Mania | contraindication | 231494001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Raynaud's phenomenon | contraindication | 266261006 | |
Retention of urine | contraindication | 267064002 | |
Pheochromocytoma | contraindication | 302835009 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial infarction in recovery phase | contraindication | 418044006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.32 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 8.69 | CHEMBL | CHEMBL | |||
Sodium-dependent serotonin transporter | Transporter | Kd | 8.05 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Kd | 5.97 | CHEMBL | |||||
Cytochrome P450 2D6 | Enzyme | Ki | 4.77 | WOMBAT-PK | |||||
G protein-activated inward rectifier potassium channel 2 | Ion channel | IC50 | 4.28 | WOMBAT-PK | |||||
Kir3.1/Kir3.2 | Ion channel | IC50 | 4.48 | WOMBAT-PK | |||||
Kir3.1/Kir3.4 | Ion channel | IC50 | 4.85 | WOMBAT-PK | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.68 | CHEMBL | |||||
Krueppel-like factor 10 | Nuclear other | IC50 | 4 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 7.37 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.85 | CHEMBL | |||||
Transporter | Transporter | Ki | 9.15 | CHEMBL | |||||
Transporter | Transporter | Ki | 8.40 | CHEMBL |
ID | Source |
---|---|
D02574 | KEGG_DRUG |
82248-59-7 | SECONDARY_CAS_RN |
353103 | RXNORM |
C0076823 | UMLSCUI |
CHEBI:331697 | CHEBI |
CHEMBL641 | ChEMBL_ID |
CHEMBL1702 | ChEMBL_ID |
DB00289 | DRUGBANK_ID |
D000069445 | MESH_DESCRIPTOR_UI |
54841 | PUBCHEM_CID |
7118 | IUPHAR_LIGAND_ID |
5354 | INN_ID |
ASW034S0B8 | UNII |
17042 | MMSL |
192105 | MMSL |
45567 | MMSL |
d04827 | MMSL |
009862 | NDDF |
009863 | NDDF |
4021364 | VANDF |
4024296 | VANDF |
407037005 | SNOMEDCT_US |
407038000 | SNOMEDCT_US |
412577007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3227 | CAPSULE | 10 mg | ORAL | NDA | 38 sections |
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3228 | CAPSULE | 25 mg | ORAL | NDA | 38 sections |
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3229 | CAPSULE | 40 mg | ORAL | NDA | 38 sections |
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3238 | CAPSULE | 18 mg | ORAL | NDA | 38 sections |
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3239 | CAPSULE | 60 mg | ORAL | NDA | 38 sections |
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3250 | CAPSULE | 80 mg | ORAL | NDA | 38 sections |
Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3251 | CAPSULE | 100 mg | ORAL | NDA | 38 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3542 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3543 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3544 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3545 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3546 | CAPSULE | 60 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3547 | CAPSULE | 80 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3548 | CAPSULE | 100 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2260 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2261 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2262 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2263 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2264 | CAPSULE | 60 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2265 | CAPSULE | 80 mg | ORAL | ANDA | 32 sections |
Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2266 | CAPSULE | 100 mg | ORAL | ANDA | 32 sections |
Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6908 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |
STRATTERA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-337 | CAPSULE | 10 mg | ORAL | NDA | 35 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-755 | CAPSULE | 10 mg | ORAL | ANDA | 34 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-755 | CAPSULE | 10 mg | ORAL | ANDA | 34 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-756 | CAPSULE | 18 mg | ORAL | ANDA | 34 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-756 | CAPSULE | 18 mg | ORAL | ANDA | 34 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-757 | CAPSULE | 25 mg | ORAL | ANDA | 34 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-757 | CAPSULE | 25 mg | ORAL | ANDA | 34 sections |
atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-758 | CAPSULE | 40 mg | ORAL | ANDA | 34 sections |