atomoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives	256	83015-26-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: LY139603 strattera atomoxetine tomoxetine (-)-Tomoxetine atomoxetine hydrochloride tomoxetine hydrochloride atomoxetine HCl tomoxetine HCl	A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER. Molecular weight: 255.36 Formula: C17H21NO CLOGP: 3.94 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 21.26 ALOGS: -4.82 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

LY139603
strattera
atomoxetine
tomoxetine
(-)-Tomoxetine
atomoxetine hydrochloride
tomoxetine hydrochloride
atomoxetine HCl
tomoxetine HCl

A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.

Molecular weight: 255.36
Formula: C17H21NO
CLOGP: 3.94
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 21.26
ALOGS: -4.82
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
80	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	27.80 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	8.39 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	94 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.85 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	9.30 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.20 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Nov. 26, 2002	FDA	LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Suicidal ideation	225.16	19.40	134	8963	55251	50540776
Prescribed overdose	149.68	19.40	66	9031	14534	50581493
Tic	112.99	19.40	29	9068	1188	50594839
Irritability	108.17	19.40	66	9031	28360	50567667
Blepharospasm	108.08	19.40	34	9063	2914	50593113
Aggression	106.84	19.40	59	9038	21057	50574970
Abnormal behaviour	102.41	19.40	56	9041	19602	50576425
Crying	74.08	19.40	46	9051	20370	50575657
Agitation	72.98	19.40	67	9030	53317	50542710
Myocarditis	72.10	19.40	33	9064	7914	50588113
Tachycardia	71.79	19.40	89	9008	99674	50496353
Suicide attempt	66.99	19.40	63	9034	51669	50544358
Depression	66.64	19.40	112	8985	165311	50430716
Disturbance in attention	65.12	19.40	50	9047	31136	50564891
Intentional self-injury	64.08	19.40	44	9053	23068	50572959
Taste disorder	61.49	19.40	30	9067	8294	50587733
Attention deficit hyperactivity disorder	60.80	19.40	21	9076	2408	50593619
Overdose	56.30	19.40	79	9018	99648	50496379
Somnolence	50.88	19.40	96	9001	154889	50441138
Impulsive behaviour	50.06	19.40	16	9081	1442	50594585
Epilepsy	48.16	19.40	36	9061	21531	50574496
Mood swings	45.70	19.40	31	9066	15923	50580104
Raynaud's phenomenon	44.93	19.40	14	9083	1162	50594865
Anxiety	44.08	19.40	98	8999	177508	50418519
Intentional overdose	43.69	19.40	55	9042	62449	50533578
Psychomotor hyperactivity	41.64	19.40	24	9073	9277	50586750
Seizure	41.15	19.40	75	9022	117799	50478228
Loss of consciousness	41.08	19.40	70	9027	104283	50491744
Mania	40.61	19.40	25	9072	10891	50585136
Trichotillomania	38.96	19.40	8	9089	118	50595909
Liver injury	37.56	19.40	33	9064	24773	50571254
Supine hypertension	37.47	19.40	7	9090	61	50595966
Anger	37.26	19.40	24	9073	11309	50584718
Electrocardiogram QT prolonged	35.22	19.40	45	9052	51841	50544186
Psychotic disorder	35.00	19.40	30	9067	21782	50574245
Memory impairment	34.94	19.40	56	9041	79304	50516723
Dystonia	33.74	19.40	23	9074	11903	50584124
Bipolar I disorder	33.68	19.40	12	9085	1506	50594521
Oppositional defiant disorder	33.53	19.40	6	9091	40	50595987
Aspartate aminotransferase increased	32.92	19.40	54	9043	77944	50518083
Obsessive-compulsive disorder	30.70	19.40	14	9083	3326	50592701
Paraesthesia	30.53	19.40	67	9030	120176	50475851
Drug screen positive	30.45	19.40	14	9083	3388	50592639
Educational problem	30.20	19.40	8	9089	371	50595656
Renal tubular acidosis	29.83	19.40	11	9086	1523	50594504
Product tampering	29.60	19.40	7	9090	203	50595824
Mydriasis	28.90	19.40	20	9077	10607	50585420
Feeling abnormal	28.60	19.40	67	9030	125425	50470602
Completed suicide	28.53	19.40	69	9028	131820	50464207
Gastrooesophageal reflux disease	28.40	19.40	50	9047	76378	50519649
Heart rate increased	28.01	19.40	50	9047	77200	50518827
Pulse abnormal	27.86	19.40	11	9086	1834	50594193
Hypomania	26.72	19.40	14	9083	4491	50591536
Piloerection	26.54	19.40	7	9090	319	50595708
Thinking abnormal	26.00	19.40	18	9079	9549	50586478
Diarrhoea	25.22	19.40	42	9055	588434	50007593
Congestive hepatopathy	24.66	19.40	11	9086	2483	50593544
Dysmenorrhoea	24.65	19.40	12	9085	3298	50592729
Mood altered	23.46	19.40	19	9078	12754	50583273
Social avoidant behaviour	23.45	19.40	11	9086	2786	50593241
Alanine aminotransferase increased	23.28	19.40	50	9047	88309	50507718
Emotional disorder	22.58	19.40	18	9079	11818	50584209
Pneumonia	22.46	19.40	21	9076	378380	50217647
Palpitations	22.12	19.40	51	9046	94455	50501572
Hypoaesthesia	21.78	19.40	61	9036	127196	50468831
Hyperhidrosis	21.75	19.40	49	9048	89377	50506650
Bipolar disorder	21.45	19.40	14	9083	6743	50589284
Personality change	21.18	19.40	13	9084	5632	50590395
Hepatitis	20.89	19.40	27	9070	31426	50564601
Joint swelling	20.86	19.40	9	9088	245277	50350750
Peripheral swelling	20.16	19.40	6	9091	205930	50390097
Insomnia	20.04	19.40	73	9024	174792	50421235
Acute kidney injury	19.98	19.40	8	9089	228050	50367977
Merycism	19.94	19.40	5	9092	186	50595841
Generalised tonic-clonic seizure	19.73	19.40	24	9073	26286	50569741
Abnormal dreams	19.48	19.40	15	9082	9362	50586665

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Suicidal ideation	665.28	23.15	328	14058	34388	29525753
Tic	559.19	23.15	138	14248	1697	29558444
Aggression	527.86	23.15	283	14103	35258	29524883
Prescribed overdose	485.69	23.15	176	14210	8507	29551634
Abnormal behaviour	342.50	23.15	184	14202	22943	29537198
Anger	260.19	23.15	120	14266	10770	29549371
Irritability	238.12	23.15	143	14243	22009	29538132
Crying	203.73	23.15	82	14304	5269	29554872
Intentional self-injury	195.17	23.15	103	14283	12358	29547783
Testicular pain	175.05	23.15	60	14326	2449	29557692
Psychomotor hyperactivity	166.96	23.15	81	14305	8132	29552009
Oppositional defiant disorder	146.99	23.15	37	14349	494	29559647
Ejaculation disorder	142.67	23.15	41	14345	927	29559214
Agitation	130.33	23.15	142	14244	51162	29508979
Homicidal ideation	129.27	23.15	48	14338	2476	29557665
Mood swings	128.06	23.15	65	14321	7186	29552955
Urinary hesitation	127.87	23.15	46	14340	2167	29557974
Suicide attempt	118.78	23.15	112	14274	33998	29526143
Disturbance in attention	112.52	23.15	89	14297	21335	29538806
Anxiety	111.72	23.15	170	14216	85195	29474946
Impulsive behaviour	110.81	23.15	40	14346	1903	29558238
Heart rate increased	106.29	23.15	112	14274	38826	29521315
Depressed mood	105.52	23.15	77	14309	16371	29543770
Acute kidney injury	99.30	23.15	8	14378	265259	29294882
Pneumonia	97.43	23.15	19	14367	320153	29239988
Death	96.64	23.15	24	14362	342060	29218081
Mood altered	93.95	23.15	55	14331	8056	29552085
Depression	92.75	23.15	156	14230	84991	29475150
Attention deficit hyperactivity disorder	91.41	23.15	36	14350	2181	29557960
Insomnia	90.61	23.15	158	14228	88603	29471538
Hallucination, auditory	90.41	23.15	57	14329	9536	29550605
Somnolence	87.91	23.15	161	14225	93794	29466347
Decreased eye contact	87.19	23.15	24	14362	461	29559680
Bruxism	84.28	23.15	31	14355	1556	29558585
Drug screen positive	81.81	23.15	39	14347	3762	29556379
Palpitations	77.12	23.15	87	14299	32517	29527624
Product substitution issue	75.36	23.15	50	14336	9122	29551019
Psychotic disorder	74.99	23.15	69	14317	20285	29539856
Mania	73.06	23.15	48	14338	8615	29551526
Alanine aminotransferase increased	70.68	23.15	125	14261	70819	29489322
Self-injurious ideation	70.37	23.15	27	14359	1524	29558617
Mydriasis	69.78	23.15	41	14345	6044	29554097
Feeling abnormal	69.11	23.15	107	14279	54338	29505803
Tachycardia	67.56	23.15	124	14262	72286	29487855
Aspartate aminotransferase increased	64.40	23.15	109	14277	59616	29500525
Seizure	63.58	23.15	140	14246	92983	29467158
Dystonia	63.32	23.15	46	14340	9703	29550438
Educational problem	63.08	23.15	19	14367	508	29559633
Suicidal behaviour	62.78	23.15	24	14362	1341	29558800
Dysuria	60.21	23.15	64	14322	22376	29537765
Penile discharge	59.68	23.15	12	14374	51	29560090
Sepsis	57.14	23.15	3	14383	142679	29417462
Anaemia	56.79	23.15	14	14372	200937	29359204
Diarrhoea	55.95	23.15	48	14338	332650	29227491
Electrocardiogram QT prolonged	55.93	23.15	78	14308	36059	29524082
Dyskinesia	55.21	23.15	58	14328	20003	29540138
Choreoathetosis	54.44	23.15	20	14366	1000	29559141
Blood alkaline phosphatase increased	54.28	23.15	68	14318	28338	29531803
Nervousness	53.05	23.15	44	14342	11262	29548879
Retching	52.57	23.15	34	14352	5939	29554202
Emotional disorder	50.76	23.15	31	14355	4900	29555241
Trismus	46.99	23.15	23	14363	2350	29557791
Headache	46.24	23.15	187	14199	173820	29386321
Generalised tonic-clonic seizure	43.42	23.15	50	14336	19089	29541052
Affect lability	41.86	23.15	24	14362	3378	29556763
Gilbert's syndrome	40.80	23.15	8	14378	29	29560112
Coordination abnormal	40.46	23.15	31	14355	7083	29553058
Febrile neutropenia	40.23	23.15	4	14382	112236	29447905
Screaming	39.98	23.15	17	14369	1253	29558888
Social avoidant behaviour	39.56	23.15	22	14364	2920	29557221
Growth retardation	38.94	23.15	18	14368	1618	29558523
Panic attack	38.22	23.15	32	14354	8294	29551847
Sexual dysfunction	36.77	23.15	27	14359	5787	29554354
Blood bilirubin increased	36.68	23.15	62	14324	33831	29526310
General physical health deterioration	36.00	23.15	4	14382	102853	29457288
Tearfulness	35.85	23.15	17	14369	1619	29558522
Paranoia	35.42	23.15	33	14353	9844	29550297
Trichotillomania	35.38	23.15	8	14378	65	29560076
Loss of consciousness	35.24	23.15	97	14289	73959	29486182
Thrombocytopenia	35.05	23.15	11	14375	134812	29425329
Thinking abnormal	34.66	23.15	25	14361	5211	29554930
Hepatic enzyme increased	34.18	23.15	60	14326	33739	29526402
Personality change	32.67	23.15	23	14363	4615	29555526
Physical assault	32.44	23.15	14	14372	1070	29559071
Renal failure	32.05	23.15	9	14377	118590	29441551
Enuresis	31.96	23.15	17	14369	2067	29558074
Pallor	31.94	23.15	45	14341	20979	29539162
Abdominal pain upper	31.13	23.15	82	14304	60911	29499230
Apathy	31.01	23.15	25	14361	6146	29553995
Sleep disorder	31.00	23.15	48	14338	24338	29535803
Fight in school	30.80	23.15	5	14381	3	29560138
Obsessive-compulsive disorder	30.64	23.15	22	14364	4554	29555587
Negativism	30.23	23.15	10	14376	365	29559776
Hyperkinesia	30.18	23.15	15	14371	1584	29558557
Scrotal pain	29.60	23.15	12	14374	784	29559357
Erectile dysfunction	29.54	23.15	40	14346	17969	29542172
Respiratory failure	28.93	23.15	6	14380	97125	29463016
Repetitive speech	28.80	23.15	7	14379	80	29560061
Cardiac failure	27.95	23.15	3	14383	79284	29480857
Syncope	27.86	23.15	95	14291	81276	29478865
Pyrexia	27.66	23.15	62	14324	287560	29272581
Hyperhidrosis	27.25	23.15	81	14305	64459	29495682
Decreased appetite	27.21	23.15	141	14245	145201	29414940
Urinary retention	26.45	23.15	52	14334	31846	29528295
Pyromania	26.29	23.15	6	14380	51	29560090
Abdominal discomfort	26.08	23.15	66	14320	47837	29512304
Hostility	25.93	23.15	11	14375	806	29559335
Speech disorder	25.41	23.15	43	14343	23473	29536668
Dyspnoea	24.93	23.15	79	14307	326653	29233488
Chest pain	24.79	23.15	114	14272	111859	29448282
Amphetamines positive	24.71	23.15	7	14379	150	29559991
Raynaud's phenomenon	24.50	23.15	8	14378	280	29559861
Asthenia	24.48	23.15	42	14344	215208	29344933
Tourette's disorder	24.42	23.15	6	14380	72	29560069
Dysphoria	23.73	23.15	14	14372	2078	29558063
Vomiting	23.50	23.15	180	14206	212080	29348061
Sedation	23.17	23.15	35	14351	17370	29542771

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Suicidal ideation	705.04	18.15	362	19268	66180	64412922
Tic	684.45	18.15	159	19471	2460	64476642
Prescribed overdose	598.18	18.15	227	19403	20104	64458998
Aggression	561.29	18.15	276	19354	45956	64433146
Abnormal behaviour	402.72	18.15	199	19431	33423	64445679
Irritability	318.18	18.15	175	19455	36571	64442531
Anger	297.70	18.15	128	19502	15613	64463489
Psychomotor hyperactivity	242.38	18.15	108	19522	14343	64464759
Crying	211.38	18.15	109	19521	19981	64459121
Intentional self-injury	202.15	18.15	120	19510	28924	64450178
Oppositional defiant disorder	178.60	18.15	39	19591	447	64478655
Agitation	172.73	18.15	171	19459	88196	64390906
Disturbance in attention	164.20	18.15	120	19510	40954	64438148
Mood swings	158.87	18.15	86	19544	17382	64461720
Ejaculation disorder	149.55	18.15	34	19596	474	64478628
Suicide attempt	145.43	18.15	141	19489	70866	64408236
Homicidal ideation	143.18	18.15	49	19581	3208	64475894
Impulsive behaviour	132.61	18.15	44	19586	2619	64476483
Anxiety	131.17	18.15	227	19403	202422	64276680
Depression	130.15	18.15	214	19416	183077	64296025
Testicular pain	128.80	18.15	39	19591	1721	64477381
Mania	115.14	18.15	68	19562	16218	64462884
Attention deficit hyperactivity disorder	111.42	18.15	39	19591	2731	64476371
Somnolence	111.27	18.15	212	19418	203433	64275669
Urinary hesitation	109.66	18.15	41	19589	3469	64475633
Heart rate increased	108.96	18.15	142	19488	98533	64380569
Educational problem	108.01	18.15	25	19605	379	64478723
Tachycardia	107.96	18.15	176	19454	149403	64329699
Seizure	96.42	18.15	178	19452	166714	64312388
Acute kidney injury	95.93	18.15	12	19618	449228	64029874
Dystonia	93.74	18.15	63	19567	18802	64460300
Hallucination, auditory	92.49	18.15	60	19570	16879	64462223
Decreased eye contact	92.16	18.15	25	19605	740	64478362
Aspartate aminotransferase increased	90.56	18.15	144	19486	119644	64359458
Product substitution issue	89.59	18.15	60	19570	17801	64461301
Blepharospasm	89.56	18.15	35	19595	3340	64475762
Insomnia	87.83	18.15	189	19441	197647	64281455
Alanine aminotransferase increased	84.99	18.15	152	19478	138879	64340223
Pneumonia	83.63	18.15	33	19597	559543	63919559
Psychotic disorder	80.96	18.15	74	19556	34504	64444598
Trichotillomania	80.51	18.15	17	19613	164	64478938
Depressed mood	79.36	18.15	79	19551	40933	64438169
Mood altered	78.52	18.15	53	19577	15926	64463176
Feeling abnormal	75.25	18.15	141	19489	133461	64345641
Bruxism	73.54	18.15	31	19599	3593	64475509
Mydriasis	73.36	18.15	50	19580	15262	64463840
Dyskinesia	70.96	18.15	73	19557	39315	64439787
Electrocardiogram QT prolonged	69.16	18.15	102	19528	79346	64399756
Self-injurious ideation	67.06	18.15	28	19602	3169	64475933
Obsessive-compulsive disorder	65.08	18.15	31	19599	4787	64474315
Drug screen positive	62.88	18.15	32	19598	5697	64473405
Diarrhoea	62.66	18.15	77	19553	722627	63756475
Death	62.02	18.15	35	19595	482670	63996432
Generalised tonic-clonic seizure	61.43	18.15	68	19562	39789	64439313
Loss of consciousness	59.31	18.15	136	19494	148229	64330873
Emotional disorder	57.64	18.15	40	19590	12567	64466535
Retching	57.39	18.15	43	19587	15213	64463889
Palpitations	57.23	18.15	109	19521	104379	64374723
Anaemia	57.04	18.15	22	19608	378658	64100444
Choreoathetosis	56.77	18.15	20	19610	1427	64477675
Suicidal behaviour	56.27	18.15	24	19606	2863	64476239
Social avoidant behaviour	54.56	18.15	27	19603	4530	64474572
Nervousness	51.83	18.15	54	19576	29502	64449600
Growth retardation	51.57	18.15	19	19611	1542	64477560
Blood alkaline phosphatase increased	51.50	18.15	74	19556	56205	64422897
Penile discharge	50.47	18.15	9	19621	31	64479071
Sepsis	49.46	18.15	6	19624	230335	64248767
Bipolar I disorder	49.24	18.15	19	19611	1752	64477350
Personality change	48.29	18.15	31	19599	8562	64470540
Affect lability	47.01	18.15	31	19599	8959	64470143
Hyperhidrosis	45.02	18.15	110	19520	124810	64354292
Thinking abnormal	44.42	18.15	33	19597	11523	64467579
Paranoia	44.25	18.15	38	19592	16314	64462788
Peripheral swelling	43.57	18.15	6	19624	209147	64269955
Nightmare	43.51	18.15	42	19588	20951	64458151
Coordination abnormal	43.01	18.15	36	19594	14928	64464174
Febrile neutropenia	40.00	18.15	5	19625	187652	64291450
Intentional overdose	39.91	18.15	86	19544	89858	64389244
Trismus	38.71	18.15	22	19608	4879	64474223
Taste disorder	38.66	18.15	28	19602	9405	64469697
Gilbert's syndrome	38.43	18.15	7	19623	28	64479074
Epilepsy	38.12	18.15	49	19581	33482	64445620
General physical health deterioration	37.88	18.15	8	19622	204417	64274685
Scrotal pain	37.46	18.15	11	19619	436	64478666
Physical assault	37.41	18.15	15	19615	1531	64477571
Thrombocytopenia	37.14	18.15	11	19619	223790	64255312
Dysuria	36.58	18.15	54	19576	42003	64437099
Overdose	36.34	18.15	119	19511	159447	64319655
Arthralgia	35.27	18.15	50	19580	442210	64036892
Speech disorder	34.87	18.15	57	19573	48384	64430718
Enuresis	34.80	18.15	17	19613	2773	64476329
Joint swelling	33.25	18.15	12	19618	215370	64263732
Hyperkinesia	33.22	18.15	16	19614	2530	64476572
Pancytopenia	32.63	18.15	3	19627	143306	64335796
Decreased appetite	32.41	18.15	170	19460	281119	64197983
Raynaud's phenomenon	32.22	18.15	12	19618	1004	64478098
Bipolar disorder	32.20	18.15	22	19608	6739	64472363
Tourette's disorder	32.15	18.15	7	19623	79	64479023
School refusal	31.85	18.15	6	19624	30	64479072
Blood bilirubin increased	31.44	18.15	60	19570	57493	64421609
Rheumatoid arthritis	31.33	18.15	6	19624	164288	64314814
Sleep disorder	31.09	18.15	61	19569	59648	64419454
Panic attack	30.99	18.15	35	19595	20918	64458184
Infection	30.83	18.15	9	19621	184871	64294231
Petit mal epilepsy	30.39	18.15	19	19611	5013	64474089
Dyspnoea	29.43	18.15	116	19514	718558	63760544
Tearfulness	29.12	18.15	18	19612	4655	64474447
Pain in extremity	28.65	18.15	30	19600	303055	64176047
Renal failure	28.25	18.15	10	19620	181678	64297424
Infusion related reaction	27.43	18.15	8	19622	164459	64314643
Feeling jittery	27.33	18.15	24	19606	10611	64468491
Hyponatraemia	27.08	18.15	6	19624	148333	64330769
Abdominal pain upper	26.87	18.15	115	19515	174915	64304187
Headache	26.75	18.15	262	19368	529205	63949897
Pyromania	26.71	18.15	5	19625	24	64479078
Viral infection	26.65	18.15	43	19587	36097	64443005
Pyrexia	26.28	18.15	85	19545	558559	63920543
Hostility	26.19	18.15	13	19617	2194	64476908
Sedation	26.15	18.15	46	19584	41416	64437686
Myocarditis	26.12	18.15	29	19601	17014	64462088
Completed suicide	26.09	18.15	136	19494	224278	64254824
Chest pain	26.06	18.15	141	19489	235839	64243263
Hypomania	25.98	18.15	18	19612	5636	64473466
Erectile dysfunction	25.67	18.15	25	19605	12602	64466500
Screaming	25.63	18.15	15	19615	3514	64475588
Product tampering	25.58	18.15	7	19623	214	64478888
Neuropathy peripheral	25.36	18.15	3	19627	117522	64361580
Urinary retention	25.29	18.15	50	19580	49151	64429951
Staring	25.11	18.15	13	19617	2397	64476705
Pain	24.81	18.15	86	19544	553425	63925677
Cardiac failure congestive	24.41	18.15	5	19625	130575	64348527
Fall	24.38	18.15	57	19573	416769	64062333
Apathy	24.27	18.15	23	19607	11209	64467893
Negativism	24.18	18.15	9	19621	751	64478351
Restlessness	23.63	18.15	43	19587	39742	64439360
Renal impairment	23.58	18.15	6	19624	135011	64344091
Euphoric mood	23.51	18.15	18	19612	6573	64472529
Vomiting	23.26	18.15	263	19367	550854	63928248
Hypotension	23.17	18.15	51	19579	380923	64098179
Infectious mononucleosis	22.94	18.15	11	19619	1722	64477380
Drooling	22.28	18.15	16	19614	5303	64473799
Supine hypertension	22.19	18.15	7	19623	354	64478748
Dysphemia	21.97	18.15	13	19617	3106	64475996
Cyanosis	21.54	18.15	30	19600	22125	64456977
Gastrointestinal haemorrhage	21.05	18.15	7	19623	132305	64346797
Treatment noncompliance	20.93	18.15	43	19587	43439	64435663
Drug hypersensitivity	20.86	18.15	25	19605	237790	64241312
Rash	20.70	18.15	71	19559	458478	64020624
Pallor	20.65	18.15	40	19590	38741	64440361
Contraindicated product administered	20.42	18.15	4	19626	107825	64371277
Dysphoria	20.24	18.15	14	19616	4374	64474728
Prostatic pain	20.21	18.15	4	19626	27	64479075
Medication error	20.15	18.15	46	19584	49920	64429182
Syncope	20.04	18.15	98	19532	157537	64321565
Hallucination	20.01	18.15	58	19572	72730	64406372
Wolff-Parkinson-White syndrome	19.96	18.15	6	19624	258	64478844
Chromaturia	19.61	18.15	29	19601	22582	64456520
Streptococcal infection	19.46	18.15	17	19613	7462	64471640
Drug abuse	19.38	18.15	8	19622	132366	64346736
Sinus tachycardia	19.38	18.15	35	19595	32153	64446949
Penile pain	19.31	18.15	8	19622	887	64478215
Fight in school	19.22	18.15	3	19627	3	64479099
Male genital atrophy	19.22	18.15	3	19627	3	64479099
Peripheral coldness	18.92	18.15	22	19608	13562	64465540
Stomatitis	18.89	18.15	5	19625	109600	64369502
Haemoglobin decreased	18.76	18.15	19	19611	195044	64284058
Gastric hypomotility	18.73	18.15	5	19625	139	64478963
Blood creatinine increased	18.63	18.15	9	19621	135773	64343329
Distractibility	18.21	18.15	7	19623	639	64478463
Pulmonary embolism	18.19	18.15	11	19619	146345	64332757

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06BA09	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics
FDA MoA	N0000000102	Norepinephrine Uptake Inhibitors
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D018759	Adrenergic Uptake Inhibitors
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
FDA EPC	N0000175695	Norepinephrine Reuptake Inhibitor
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35640	adrenergic uptake inhibitors
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:78298	environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Attention deficit hyperactivity disorder	indication	406506008
Delay when starting to pass urine	contraindication	5972002
Priapism	contraindication	6273006	DOID:9286
Suicidal thoughts	contraindication	6471006
Sinus tachycardia	contraindication	11092001
Bipolar disorder	contraindication	13746004	DOID:3312
Hyperbilirubinemia	contraindication	14783006	DOID:2741
Myocardial infarction	contraindication	22298006	DOID:5844
Feeling agitated	contraindication	24199005
Orthostatic hypotension	contraindication	28651003
Hypertensive disorder	contraindication	38341003	DOID:10763
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Feeling irritable	contraindication	55929007
Aggressive behavior	contraindication	61372001
Cerebrovascular disease	contraindication	62914000	DOID:6713
Psychotic disorder	contraindication	69322001
Cardiomyopathy	contraindication	85898001	DOID:0050700
Structural disorder of heart	contraindication	128599005
Seizure disorder	contraindication	128613002
Liver function tests abnormal	contraindication	166603001
Cerebrovascular accident	contraindication	230690007
Mania	contraindication	231494001
Disease of liver	contraindication	235856003	DOID:409
Raynaud's phenomenon	contraindication	266261006
Retention of urine	contraindication	267064002
Pheochromocytoma	contraindication	302835009
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Disorder of coronary artery	contraindication	414024009
Myocardial infarction in recovery phase	contraindication	418044006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.32	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	INHIBITOR	Kd	8.69	CHEMBL	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Kd	8.05	CHEMBL
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Kd	5.97	CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		Ki	4.77	WOMBAT-PK
G protein-activated inward rectifier potassium channel 2	Ion channel	P48051	KCNJ6_HUMAN		IC50	4.28	WOMBAT-PK
Kir3.1/Kir3.2	Ion channel	P48051 P48549	KCNJ6_HUMAN KCNJ3_HUMAN		IC50	4.48	WOMBAT-PK
Kir3.1/Kir3.4	Ion channel	P48544 P48549	KCNJ5_HUMAN KCNJ3_HUMAN		IC50	4.85	WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5.68	CHEMBL
Krueppel-like factor 10	Nuclear other	Q13118	KLF10_HUMAN		IC50	4	CHEMBL
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		Ki	7.37	CHEMBL
Sodium-dependent dopamine transporter	Transporter		SC6A3_RAT		Ki	5.85	CHEMBL
Transporter	Transporter		Q9WTR4_RAT		Ki	9.15	CHEMBL
Transporter	Transporter		Q63380_RAT		Ki	8.40	CHEMBL

External reference:

ID	Source
D02574	KEGG_DRUG
82248-59-7	SECONDARY_CAS_RN
353103	RXNORM
C0076823	UMLSCUI
CHEBI:331697	CHEBI
CHEMBL641	ChEMBL_ID
CHEMBL1702	ChEMBL_ID
DB00289	DRUGBANK_ID
D000069445	MESH_DESCRIPTOR_UI
54841	PUBCHEM_CID
7118	IUPHAR_LIGAND_ID
5354	INN_ID
ASW034S0B8	UNII
17042	MMSL
192105	MMSL
45567	MMSL
d04827	MMSL
009862	NDDF
009863	NDDF
4021364	VANDF
4024296	VANDF
407037005	SNOMEDCT_US
407038000	SNOMEDCT_US
412577007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3227	CAPSULE	10 mg	ORAL	NDA	38 sections
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3228	CAPSULE	25 mg	ORAL	NDA	38 sections
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3229	CAPSULE	40 mg	ORAL	NDA	38 sections
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3238	CAPSULE	18 mg	ORAL	NDA	38 sections
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3239	CAPSULE	60 mg	ORAL	NDA	38 sections
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3250	CAPSULE	80 mg	ORAL	NDA	38 sections
Strattera	HUMAN PRESCRIPTION DRUG LABEL	1	0002-3251	CAPSULE	100 mg	ORAL	NDA	38 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3542	CAPSULE	10 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3543	CAPSULE	18 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3544	CAPSULE	25 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3545	CAPSULE	40 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3546	CAPSULE	60 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3547	CAPSULE	80 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3548	CAPSULE	100 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2260	CAPSULE	10 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2261	CAPSULE	18 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2262	CAPSULE	25 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2263	CAPSULE	40 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2264	CAPSULE	60 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2265	CAPSULE	80 mg	ORAL	ANDA	32 sections
Atomoxetine hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2266	CAPSULE	100 mg	ORAL	ANDA	32 sections
Atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6908	CAPSULE	40 mg	ORAL	ANDA	31 sections
STRATTERA	HUMAN PRESCRIPTION DRUG LABEL	1	16590-337	CAPSULE	10 mg	ORAL	NDA	35 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-755	CAPSULE	10 mg	ORAL	ANDA	34 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-755	CAPSULE	10 mg	ORAL	ANDA	34 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-756	CAPSULE	18 mg	ORAL	ANDA	34 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-756	CAPSULE	18 mg	ORAL	ANDA	34 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-757	CAPSULE	25 mg	ORAL	ANDA	34 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-757	CAPSULE	25 mg	ORAL	ANDA	34 sections
atomoxetine	HUMAN PRESCRIPTION DRUG LABEL	1	16714-758	CAPSULE	40 mg	ORAL	ANDA	34 sections