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atomoxetine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 256 | 83015-26-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 80 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 27.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.39 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.85 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 9.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 5.20 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.308 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.671 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 36.308 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 32.509 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 12.480 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 31.670 | % | High | 1 |
| herg | hERG pIC50 | 5.480 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 12.912 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 9.183 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 26.860 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1 | 38 | |||
| kinase-selectivity-class | AKT3,AXL,BRAF,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4 | 8 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.681 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 126.765 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 19.170 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.905 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 33.490 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 212.324 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 44.500 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 18.150 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 879.023 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 26, 2002 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blepharospasm | 919.19 | 25.34 | 565 | 71900 | 54880 | 90501102 |
| Epilepsy | 754.86 | 25.34 | 582 | 71883 | 81624 | 90474358 |
| Taste disorder | 714.51 | 25.34 | 502 | 71963 | 61044 | 90494938 |
| Onychomadesis | 604.29 | 25.34 | 405 | 72060 | 45593 | 90510389 |
| Nail disorder | 574.67 | 25.34 | 433 | 72032 | 58634 | 90497348 |
| Breast cancer stage III | 549.91 | 25.34 | 490 | 71975 | 83957 | 90472025 |
| Facet joint syndrome | 497.17 | 25.34 | 496 | 71969 | 97893 | 90458089 |
| Back injury | 496.64 | 25.34 | 361 | 72104 | 46261 | 90509721 |
| Onychomycosis | 420.01 | 25.34 | 299 | 72166 | 37077 | 90518905 |
| Hypercholesterolaemia | 417.23 | 25.34 | 457 | 72008 | 100435 | 90455547 |
| Peripheral venous disease | 414.59 | 25.34 | 418 | 72047 | 83503 | 90472479 |
| Product quality issue | 404.54 | 25.34 | 402 | 72063 | 78923 | 90477059 |
| Lip dry | 399.71 | 25.34 | 447 | 72018 | 100508 | 90455474 |
| Gastrooesophageal reflux disease | 373.55 | 25.34 | 556 | 71909 | 165781 | 90390201 |
| Bursitis | 360.64 | 25.34 | 484 | 71981 | 131170 | 90424812 |
| Wound infection | 341.28 | 25.34 | 423 | 72042 | 105979 | 90450003 |
| Product label confusion | 331.12 | 25.34 | 214 | 72251 | 22636 | 90533346 |
| Obesity | 313.85 | 25.34 | 404 | 72061 | 105103 | 90450879 |
| Live birth | 298.97 | 25.34 | 342 | 72123 | 78765 | 90477217 |
| C-reactive protein increased | 291.25 | 25.34 | 521 | 71944 | 180868 | 90375114 |
| Type 2 diabetes mellitus | 286.55 | 25.34 | 552 | 71913 | 202692 | 90353290 |
| Memory impairment | 282.12 | 25.34 | 539 | 71926 | 196705 | 90359277 |
| Liver injury | 263.73 | 25.34 | 482 | 71983 | 170085 | 90385897 |
| Adverse reaction | 258.63 | 25.34 | 204 | 72261 | 29508 | 90526474 |
| Psoriatic arthropathy | 256.85 | 25.34 | 565 | 71900 | 227770 | 90328212 |
| Grip strength decreased | 245.27 | 25.34 | 335 | 72130 | 92241 | 90463741 |
| Dry mouth | 241.35 | 25.34 | 485 | 71980 | 183574 | 90372408 |
| Inflammation | 240.66 | 25.34 | 476 | 71989 | 178116 | 90377866 |
| Finger deformity | 238.35 | 25.34 | 203 | 72262 | 32694 | 90523288 |
| Lung disorder | 230.96 | 25.34 | 423 | 72042 | 149460 | 90406522 |
| Coeliac disease | 230.88 | 25.34 | 228 | 72237 | 44382 | 90511600 |
| Muscle injury | 227.45 | 25.34 | 462 | 72003 | 176192 | 90379790 |
| Joint range of motion decreased | 227.17 | 25.34 | 397 | 72068 | 135246 | 90420736 |
| Night sweats | 226.29 | 25.34 | 385 | 72080 | 128381 | 90427601 |
| Folliculitis | 222.27 | 25.34 | 499 | 71966 | 203854 | 90352128 |
| Blood cholesterol increased | 218.54 | 25.34 | 501 | 71964 | 207511 | 90348471 |
| Anaemia | 217.83 | 25.34 | 17 | 72448 | 352785 | 90203197 |
| Gait inability | 217.71 | 25.34 | 407 | 72058 | 146049 | 90409933 |
| Fibromyalgia | 205.95 | 25.34 | 487 | 71978 | 205782 | 90350200 |
| Hypoaesthesia | 204.19 | 25.34 | 633 | 71832 | 313577 | 90242405 |
| Paraesthesia | 201.90 | 25.34 | 545 | 71920 | 249781 | 90306201 |
| Infusion site reaction | 201.68 | 25.34 | 147 | 72318 | 18892 | 90537090 |
| Acute kidney injury | 199.01 | 25.34 | 15 | 72450 | 320372 | 90235610 |
| Pericarditis | 186.48 | 25.34 | 556 | 71909 | 269595 | 90286387 |
| Osteoarthritis | 185.57 | 25.34 | 453 | 72012 | 195277 | 90360705 |
| Musculoskeletal pain | 181.51 | 25.34 | 414 | 72051 | 170837 | 90385145 |
| Duodenal ulcer perforation | 176.61 | 25.34 | 480 | 71985 | 220808 | 90335174 |
| Irritable bowel syndrome | 174.65 | 25.34 | 459 | 72006 | 206989 | 90348993 |
| Helicobacter infection | 174.03 | 25.34 | 485 | 71980 | 226365 | 90329617 |
| Neck pain | 173.44 | 25.34 | 320 | 72145 | 113643 | 90442339 |
| Pyrexia | 169.75 | 25.34 | 167 | 72298 | 660318 | 89895664 |
| Liver function test increased | 169.66 | 25.34 | 269 | 72196 | 84586 | 90471396 |
| Drug-induced liver injury | 169.24 | 25.34 | 278 | 72187 | 90040 | 90465942 |
| Abdominal pain upper | 167.29 | 25.34 | 615 | 71850 | 332059 | 90223923 |
| Rheumatic fever | 166.51 | 25.34 | 374 | 72091 | 152747 | 90403235 |
| Sleep disorder | 152.46 | 25.34 | 424 | 72041 | 197606 | 90358376 |
| Depression | 150.49 | 25.34 | 555 | 71910 | 300046 | 90255936 |
| Back pain | 149.62 | 25.34 | 35 | 72430 | 317140 | 90238842 |
| Neutropenia | 147.13 | 25.34 | 8 | 72457 | 224896 | 90331086 |
| Injection site reaction | 146.99 | 25.34 | 264 | 72201 | 91816 | 90464166 |
| Anti-cyclic citrullinated peptide antibody positive | 145.81 | 25.34 | 468 | 71997 | 235965 | 90320017 |
| Urinary tract infection | 145.61 | 25.34 | 33 | 72432 | 305599 | 90250383 |
| Impaired healing | 143.91 | 25.34 | 463 | 72002 | 233736 | 90322246 |
| Cough | 143.06 | 25.34 | 58 | 72407 | 368904 | 90187078 |
| Pruritus | 140.11 | 25.34 | 136 | 72329 | 541389 | 90014593 |
| Intentional product use issue | 138.93 | 25.34 | 435 | 72030 | 216457 | 90339525 |
| Muscle spasms | 134.48 | 25.34 | 475 | 71990 | 251408 | 90304574 |
| Hepatitis | 134.21 | 25.34 | 219 | 72246 | 70520 | 90485462 |
| Lower respiratory tract infection | 133.23 | 25.34 | 472 | 71993 | 250187 | 90305795 |
| Abdominal distension | 133.12 | 25.34 | 311 | 72154 | 130290 | 90425692 |
| C-reactive protein abnormal | 132.68 | 25.34 | 306 | 72159 | 127123 | 90428859 |
| Thrombocytopenia | 128.92 | 25.34 | 10 | 72455 | 208715 | 90347267 |
| Hand deformity | 124.62 | 25.34 | 518 | 71947 | 295844 | 90260138 |
| Overlap syndrome | 123.67 | 25.34 | 80 | 72385 | 8468 | 90547514 |
| Hypotension | 123.15 | 25.34 | 53 | 72412 | 325344 | 90230638 |
| Pemphigus | 121.90 | 25.34 | 551 | 71914 | 326313 | 90229669 |
| Wheezing | 121.13 | 25.34 | 442 | 72023 | 237638 | 90318344 |
| Maternal exposure during pregnancy | 118.99 | 25.34 | 586 | 71879 | 359477 | 90196505 |
| Confusional state | 118.83 | 25.34 | 616 | 71849 | 385589 | 90170393 |
| Wound | 116.93 | 25.34 | 516 | 71949 | 302464 | 90253518 |
| Erythema | 112.74 | 25.34 | 23 | 72442 | 229223 | 90326759 |
| Blister | 111.35 | 25.34 | 451 | 72014 | 254547 | 90301435 |
| Dyspepsia | 110.32 | 25.34 | 379 | 72086 | 197781 | 90358201 |
| Sepsis | 109.96 | 25.34 | 9 | 72456 | 179805 | 90376177 |
| Normal newborn | 109.14 | 25.34 | 113 | 72352 | 23249 | 90532733 |
| Constipation | 108.78 | 25.34 | 44 | 72421 | 280351 | 90275631 |
| Synovitis | 105.61 | 25.34 | 532 | 71933 | 329220 | 90226762 |
| Death | 103.30 | 25.34 | 128 | 72337 | 456423 | 90099559 |
| Systemic lupus erythematosus | 100.28 | 25.34 | 561 | 71904 | 361335 | 90194647 |
| Dehydration | 98.80 | 25.34 | 18 | 72447 | 194429 | 90361553 |
| White blood cell count decreased | 97.80 | 25.34 | 10 | 72455 | 167099 | 90388883 |
| Glossodynia | 96.68 | 25.34 | 510 | 71955 | 321269 | 90234713 |
| Haemoglobin decreased | 96.60 | 25.34 | 9 | 72456 | 161947 | 90394035 |
| Hepatic enzyme | 92.38 | 25.34 | 56 | 72409 | 5288 | 90550694 |
| Rheumatoid arthritis | 91.90 | 25.34 | 549 | 71916 | 362065 | 90193917 |
| Ill-defined disorder | 90.42 | 25.34 | 339 | 72126 | 184552 | 90371430 |
| Stomatitis | 89.20 | 25.34 | 445 | 72020 | 274253 | 90281729 |
| Renal failure | 87.76 | 25.34 | 4 | 72461 | 131003 | 90424979 |
| Neuropathy peripheral | 86.17 | 25.34 | 6 | 72459 | 136964 | 90419018 |
| Product use in unapproved indication | 80.70 | 25.34 | 502 | 71963 | 335734 | 90220248 |
| Prescribed overdose | 79.00 | 25.34 | 213 | 72252 | 97412 | 90458570 |
| COVID-19 | 78.84 | 25.34 | 19 | 72446 | 168824 | 90387158 |
| Arthropathy | 75.87 | 25.34 | 527 | 71938 | 365715 | 90190267 |
| Hyponatraemia | 75.58 | 25.34 | 9 | 72456 | 133529 | 90422453 |
| Influenza | 74.96 | 25.34 | 11 | 72454 | 139253 | 90416729 |
| Product dose omission issue | 74.46 | 25.34 | 74 | 72391 | 291613 | 90264369 |
| Injury | 71.47 | 25.34 | 330 | 72135 | 197019 | 90358963 |
| General physical health deterioration | 70.05 | 25.34 | 505 | 71960 | 354610 | 90201372 |
| Renal impairment | 68.15 | 25.34 | 4 | 72461 | 105417 | 90450565 |
| Diarrhoea | 67.58 | 25.34 | 457 | 72008 | 938733 | 89617249 |
| Arthritis | 66.93 | 25.34 | 25 | 72440 | 167290 | 90388692 |
| Platelet count decreased | 66.78 | 25.34 | 14 | 72451 | 136955 | 90419027 |
| Cardiac failure congestive | 66.15 | 25.34 | 3 | 72462 | 98691 | 90457291 |
| Fatigue | 66.09 | 25.34 | 598 | 71867 | 1153425 | 89402557 |
| Cerebrovascular accident | 65.93 | 25.34 | 10 | 72455 | 123523 | 90432459 |
| Urticaria | 65.92 | 25.34 | 452 | 72013 | 312282 | 90243700 |
| Myocardial infarction | 62.89 | 25.34 | 6 | 72459 | 105966 | 90450016 |
| Respiratory failure | 62.26 | 25.34 | 10 | 72455 | 118408 | 90437574 |
| Mobility decreased | 61.15 | 25.34 | 376 | 72089 | 250358 | 90305624 |
| Tic | 60.85 | 25.34 | 30 | 72435 | 1881 | 90554101 |
| Pulmonary embolism | 60.53 | 25.34 | 15 | 72450 | 130805 | 90425177 |
| Herpes zoster | 59.95 | 25.34 | 4 | 72461 | 94640 | 90461342 |
| Drug interaction | 59.88 | 25.34 | 80 | 72385 | 276373 | 90279609 |
| Gastrointestinal haemorrhage | 59.65 | 25.34 | 3 | 72462 | 90245 | 90465737 |
| Blood creatinine increased | 59.48 | 25.34 | 6 | 72459 | 101380 | 90454602 |
| Hypokalaemia | 58.82 | 25.34 | 16 | 72449 | 131100 | 90424882 |
| Injection site pain | 58.54 | 25.34 | 33 | 72432 | 173666 | 90382316 |
| Infection | 58.05 | 25.34 | 127 | 72338 | 361967 | 90194015 |
| Dyspnoea | 57.36 | 25.34 | 441 | 72024 | 880514 | 89675468 |
| Drug ineffective | 56.77 | 25.34 | 774 | 71691 | 1383524 | 89172458 |
| Suicidal ideation | 56.62 | 25.34 | 158 | 72307 | 73697 | 90482285 |
| Swelling | 56.47 | 25.34 | 547 | 71918 | 418511 | 90137471 |
| Product tampering | 56.20 | 25.34 | 19 | 72446 | 444 | 90555538 |
| Infusion related reaction | 56.15 | 25.34 | 544 | 71921 | 416236 | 90139746 |
| Hypocholesterolaemia | 55.50 | 25.34 | 44 | 72421 | 6405 | 90549577 |
| Underdose | 55.39 | 25.34 | 129 | 72336 | 53888 | 90502094 |
| Hepatic enzyme increased | 55.22 | 25.34 | 484 | 71981 | 360252 | 90195730 |
| Chest discomfort | 54.79 | 25.34 | 21 | 72444 | 138344 | 90417638 |
| Cellulitis | 54.66 | 25.34 | 5 | 72460 | 91332 | 90464650 |
| Chills | 54.01 | 25.34 | 19 | 72446 | 131962 | 90424020 |
| Oropharyngeal pain | 53.69 | 25.34 | 13 | 72452 | 115174 | 90440808 |
| Breast cancer stage II | 53.43 | 25.34 | 99 | 72366 | 35235 | 90520747 |
| Therapeutic product effect incomplete | 53.22 | 25.34 | 300 | 72165 | 193596 | 90362386 |
| Sinusitis | 51.23 | 25.34 | 125 | 72340 | 342963 | 90213019 |
| Adulterated product | 51.12 | 25.34 | 17 | 72448 | 377 | 90555605 |
| Contraindicated product administered | 50.80 | 25.34 | 433 | 72032 | 319706 | 90236276 |
| Exposure during pregnancy | 49.27 | 25.34 | 343 | 72122 | 238067 | 90317915 |
| Weight decreased | 48.09 | 25.34 | 150 | 72315 | 379760 | 90176222 |
| Bradycardia | 46.59 | 25.34 | 6 | 72459 | 83841 | 90472141 |
| Injection site erythema | 46.14 | 25.34 | 11 | 72454 | 98491 | 90457491 |
| Drug intolerance | 45.35 | 25.34 | 552 | 71913 | 447039 | 90108943 |
| Anaphylactic reaction | 44.66 | 25.34 | 8 | 72457 | 87516 | 90468466 |
| Therapeutic product effect decreased | 43.27 | 25.34 | 374 | 72091 | 277197 | 90278785 |
| Balance disorder | 43.25 | 25.34 | 12 | 72453 | 97068 | 90458914 |
| Neutrophil count decreased | 42.58 | 25.34 | 4 | 72461 | 71528 | 90484454 |
| Productive cough | 41.66 | 25.34 | 6 | 72459 | 77057 | 90478925 |
| Abdominal discomfort | 41.35 | 25.34 | 572 | 71893 | 476756 | 90079226 |
| Hypertension | 41.15 | 25.34 | 552 | 71913 | 456980 | 90099002 |
| Rhinorrhoea | 41.10 | 25.34 | 10 | 72455 | 88306 | 90467676 |
| Upper respiratory tract infection | 40.95 | 25.34 | 26 | 72439 | 128292 | 90427690 |
| Leukopenia | 40.35 | 25.34 | 15 | 72450 | 100695 | 90455287 |
| Muscular weakness | 40.17 | 25.34 | 293 | 72172 | 206373 | 90349609 |
| Atrial fibrillation | 40.06 | 25.34 | 29 | 72436 | 133582 | 90422400 |
| Claustrophobia | 39.79 | 25.34 | 20 | 72445 | 1307 | 90554675 |
| Myalgia | 39.63 | 25.34 | 49 | 72416 | 175076 | 90380906 |
| Congenital anomaly | 39.61 | 25.34 | 36 | 72429 | 6311 | 90549671 |
| Incorrect route of product administration | 38.50 | 25.34 | 108 | 72357 | 50518 | 90505464 |
| Dysphagia | 38.30 | 25.34 | 21 | 72444 | 112257 | 90443725 |
| Pulse abnormal | 37.75 | 25.34 | 26 | 72439 | 3053 | 90552929 |
| Chronic obstructive pulmonary disease | 37.13 | 25.34 | 7 | 72458 | 73822 | 90482160 |
| Gastrointestinal disorder | 36.48 | 25.34 | 339 | 72126 | 256348 | 90299634 |
| Vertigo | 36.46 | 25.34 | 6 | 72459 | 69805 | 90486177 |
| Dysphonia | 36.32 | 25.34 | 4 | 72461 | 63080 | 90492902 |
| Blood pressure increased | 36.04 | 25.34 | 64 | 72401 | 197153 | 90358829 |
| Nausea | 35.86 | 25.34 | 649 | 71816 | 1109667 | 89446315 |
| Toxicity to various agents | 35.46 | 25.34 | 115 | 72350 | 287731 | 90268251 |
| Dry eye | 35.12 | 25.34 | 3 | 72462 | 57928 | 90498054 |
| Pneumonia | 34.91 | 25.34 | 334 | 72131 | 637725 | 89918257 |
| Thrombosis | 34.66 | 25.34 | 8 | 72457 | 73243 | 90482739 |
| Hypoglycaemia | 34.33 | 25.34 | 7 | 72458 | 69841 | 90486141 |
| Cystitis | 34.25 | 25.34 | 6 | 72459 | 66712 | 90489270 |
| Blood glucose increased | 33.69 | 25.34 | 17 | 72448 | 95229 | 90460753 |
| Bronchitis | 33.35 | 25.34 | 44 | 72421 | 152883 | 90403099 |
| Haematochezia | 33.05 | 25.34 | 8 | 72457 | 70905 | 90485077 |
| Deep vein thrombosis | 32.94 | 25.34 | 16 | 72449 | 91604 | 90464378 |
| Blood pressure systolic increased | 32.84 | 25.34 | 4 | 72461 | 58341 | 90497641 |
| Myocarditis | 32.14 | 25.34 | 47 | 72418 | 13759 | 90542223 |
| Burning sensation | 31.94 | 25.34 | 6 | 72459 | 63446 | 90492536 |
| Cholelithiasis | 31.08 | 25.34 | 3 | 72462 | 52503 | 90503479 |
| Rash erythematous | 31.03 | 25.34 | 7 | 72458 | 65097 | 90490885 |
| Angioedema | 30.87 | 25.34 | 7 | 72458 | 64869 | 90491113 |
| Diabetes mellitus | 30.87 | 25.34 | 7 | 72458 | 64868 | 90491114 |
| Attention deficit hyperactivity disorder | 30.66 | 25.34 | 26 | 72439 | 4158 | 90551824 |
| Influenza like illness | 30.66 | 25.34 | 13 | 72452 | 80598 | 90475384 |
| Depressed level of consciousness | 30.60 | 25.34 | 10 | 72455 | 72774 | 90483208 |
| Epistaxis | 30.40 | 25.34 | 15 | 72450 | 85110 | 90470872 |
| Haemorrhage | 30.11 | 25.34 | 9 | 72456 | 69360 | 90486622 |
| Abnormal behaviour | 30.03 | 25.34 | 60 | 72405 | 22568 | 90533414 |
| Hyperglycaemia | 29.94 | 25.34 | 3 | 72462 | 50967 | 90505015 |
| Adverse event | 29.80 | 25.34 | 178 | 72287 | 117240 | 90438742 |
| Chronic kidney disease | 29.36 | 25.34 | 3 | 72462 | 50188 | 90505794 |
| Therapy interrupted | 29.30 | 25.34 | 3 | 72462 | 50105 | 90505877 |
| Pleural effusion | 29.02 | 25.34 | 28 | 72437 | 111963 | 90444019 |
| Congestive hepatopathy | 28.94 | 25.34 | 22 | 72443 | 3011 | 90552971 |
| Weight increased | 28.88 | 25.34 | 482 | 71983 | 417445 | 90138537 |
| Bone pain | 28.87 | 25.34 | 7 | 72458 | 61976 | 90494006 |
| Coma | 28.79 | 25.34 | 11 | 72454 | 72621 | 90483361 |
| Aggression | 28.79 | 25.34 | 65 | 72400 | 26603 | 90529379 |
| Treatment failure | 28.67 | 25.34 | 370 | 72095 | 303558 | 90252424 |
| Metabolic acidosis | 28.60 | 25.34 | 5 | 72460 | 55671 | 90500311 |
| Oedema peripheral | 28.43 | 25.34 | 108 | 72357 | 257807 | 90298175 |
| Flushing | 28.14 | 25.34 | 18 | 72447 | 88473 | 90467509 |
| Inappropriate schedule of product administration | 27.98 | 25.34 | 48 | 72417 | 149885 | 90406097 |
| Dry skin | 27.89 | 25.34 | 18 | 72447 | 88055 | 90467927 |
| Oxygen saturation decreased | 27.70 | 25.34 | 27 | 72438 | 107456 | 90448526 |
| Prescribed underdose | 27.53 | 25.34 | 126 | 72339 | 74893 | 90481089 |
| International normalised ratio increased | 27.24 | 25.34 | 3 | 72462 | 47313 | 90508669 |
| Supine hypertension | 27.06 | 25.34 | 7 | 72458 | 61 | 90555921 |
| Impulsive behaviour | 27.03 | 25.34 | 17 | 72448 | 1713 | 90554269 |
| Respiratory tract infection | 26.88 | 25.34 | 7 | 72458 | 59071 | 90496911 |
| Hypothyroidism | 26.79 | 25.34 | 5 | 72460 | 53122 | 90502860 |
| Cognitive disorder | 26.71 | 25.34 | 11 | 72454 | 69396 | 90486586 |
| Cardiac failure | 26.53 | 25.34 | 29 | 72436 | 109467 | 90446515 |
| Red blood cell count decreased | 26.53 | 25.34 | 3 | 72462 | 46348 | 90509634 |
| Trichotillomania | 26.38 | 25.34 | 8 | 72457 | 130 | 90555852 |
| Blood pressure fluctuation | 26.29 | 25.34 | 5 | 72460 | 52408 | 90503574 |
| Multiple sclerosis relapse | 26.21 | 25.34 | 5 | 72460 | 52300 | 90503682 |
| Hepatotoxicity | 26.15 | 25.34 | 3 | 72462 | 45839 | 90510143 |
| Ulcer haemorrhage | 26.04 | 25.34 | 62 | 72403 | 26259 | 90529723 |
| Skin exfoliation | 25.75 | 25.34 | 11 | 72454 | 67902 | 90488080 |
| Cardiac disorder | 25.39 | 25.34 | 7 | 72458 | 56865 | 90499117 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Suicidal ideation | 715.62 | 21.93 | 358 | 16454 | 47803 | 42556720 |
| Tic | 622.66 | 21.93 | 152 | 16660 | 2231 | 42602292 |
| Aggression | 599.56 | 21.93 | 309 | 16503 | 43854 | 42560669 |
| Prescribed overdose | 467.51 | 21.93 | 180 | 16632 | 12747 | 42591776 |
| Abnormal behaviour | 369.87 | 21.93 | 189 | 16623 | 26262 | 42578261 |
| Anger | 270.03 | 21.93 | 122 | 16690 | 12896 | 42591627 |
| Irritability | 260.16 | 21.93 | 153 | 16659 | 27975 | 42576548 |
| Intentional self-injury | 216.34 | 21.93 | 110 | 16702 | 15092 | 42589431 |
| Crying | 213.20 | 21.93 | 84 | 16728 | 6310 | 42598213 |
| Psychomotor hyperactivity | 190.83 | 21.93 | 91 | 16721 | 10867 | 42593656 |
| Agitation | 189.01 | 21.93 | 175 | 16637 | 64139 | 42540384 |
| Oppositional defiant disorder | 172.58 | 21.93 | 41 | 16771 | 531 | 42603992 |
| Testicular pain | 172.07 | 21.93 | 60 | 16752 | 3194 | 42601329 |
| Ejaculation disorder | 157.18 | 21.93 | 43 | 16769 | 1005 | 42603518 |
| Homicidal ideation | 141.91 | 21.93 | 50 | 16762 | 2744 | 42601779 |
| Anxiety | 136.64 | 21.93 | 199 | 16613 | 118361 | 42486162 |
| Suicide attempt | 130.64 | 21.93 | 123 | 16689 | 45977 | 42558546 |
| Mood swings | 128.85 | 21.93 | 65 | 16747 | 8761 | 42595762 |
| Urinary hesitation | 126.76 | 21.93 | 47 | 16765 | 2988 | 42601535 |
| Impulsive behaviour | 121.65 | 21.93 | 43 | 16769 | 2382 | 42602141 |
| Insomnia | 119.89 | 21.93 | 187 | 16625 | 118066 | 42486457 |
| Disturbance in attention | 115.29 | 21.93 | 95 | 16717 | 29771 | 42574752 |
| Heart rate increased | 110.42 | 21.93 | 120 | 16692 | 53135 | 42551388 |
| Death | 107.53 | 21.93 | 27 | 16785 | 471158 | 42133365 |
| Psychotic disorder | 106.71 | 21.93 | 90 | 16722 | 29118 | 42575405 |
| Mood altered | 106.15 | 21.93 | 61 | 16751 | 10657 | 42593866 |
| Depressed mood | 104.36 | 21.93 | 81 | 16731 | 23303 | 42581220 |
| Acute kidney injury | 103.53 | 21.93 | 12 | 16800 | 367325 | 42237198 |
| Decreased eye contact | 99.98 | 21.93 | 26 | 16786 | 497 | 42604026 |
| Hallucination, auditory | 97.34 | 21.93 | 65 | 16747 | 14799 | 42589724 |
| Attention deficit hyperactivity disorder | 97.20 | 21.93 | 39 | 16773 | 3069 | 42601454 |
| Depression | 93.76 | 21.93 | 162 | 16650 | 111201 | 42493322 |
| Mania | 91.23 | 21.93 | 55 | 16757 | 10492 | 42594031 |
| Pneumonia | 90.98 | 21.93 | 27 | 16785 | 422122 | 42182401 |
| Bruxism | 88.42 | 21.93 | 33 | 16779 | 2136 | 42602387 |
| Seizure | 88.24 | 21.93 | 165 | 16647 | 120396 | 42484127 |
| Drug screen positive | 86.51 | 21.93 | 39 | 16773 | 4092 | 42600431 |
| Product substitution issue | 85.27 | 21.93 | 54 | 16758 | 11236 | 42593287 |
| Somnolence | 80.41 | 21.93 | 174 | 16638 | 140931 | 42463592 |
| Alanine aminotransferase increased | 78.86 | 21.93 | 132 | 16680 | 88274 | 42516249 |
| Palpitations | 76.20 | 21.93 | 97 | 16715 | 50700 | 42553823 |
| Dystonia | 74.42 | 21.93 | 52 | 16760 | 12738 | 42591785 |
| Feeling abnormal | 72.91 | 21.93 | 112 | 16700 | 69674 | 42534849 |
| Self-injurious ideation | 70.99 | 21.93 | 27 | 16785 | 1841 | 42602682 |
| Educational problem | 69.72 | 21.93 | 20 | 16792 | 558 | 42603965 |
| Tachycardia | 68.56 | 21.93 | 134 | 16678 | 100953 | 42503570 |
| Aspartate aminotransferase increased | 68.52 | 21.93 | 115 | 16697 | 77048 | 42527475 |
| Suicidal behaviour | 68.46 | 21.93 | 25 | 16787 | 1521 | 42603002 |
| Anaemia | 65.87 | 21.93 | 15 | 16797 | 280263 | 42324260 |
| Penile discharge | 65.15 | 21.93 | 13 | 16799 | 68 | 42604455 |
| Mydriasis | 63.87 | 21.93 | 41 | 16771 | 8729 | 42595794 |
| Sepsis | 62.88 | 21.93 | 4 | 16808 | 199330 | 42405193 |
| Dysuria | 62.55 | 21.93 | 69 | 16743 | 31027 | 42573496 |
| Choreoathetosis | 60.75 | 21.93 | 21 | 16791 | 1088 | 42603435 |
| Dyskinesia | 59.31 | 21.93 | 61 | 16751 | 25329 | 42579194 |
| Blood alkaline phosphatase increased | 58.19 | 21.93 | 69 | 16743 | 33528 | 42570995 |
| Emotional disorder | 57.39 | 21.93 | 34 | 16778 | 6280 | 42598243 |
| Generalised tonic-clonic seizure | 57.36 | 21.93 | 61 | 16751 | 26318 | 42578205 |
| Nervousness | 56.32 | 21.93 | 45 | 16767 | 13487 | 42591036 |
| Electrocardiogram QT prolonged | 54.40 | 21.93 | 80 | 16732 | 47865 | 42556658 |
| Diarrhoea | 53.52 | 21.93 | 62 | 16750 | 460787 | 42143736 |
| Trismus | 53.40 | 21.93 | 25 | 16787 | 2859 | 42601664 |
| Retching | 53.12 | 21.93 | 35 | 16777 | 7786 | 42596737 |
| Obsessive-compulsive disorder | 52.79 | 21.93 | 33 | 16779 | 6710 | 42597813 |
| Febrile neutropenia | 52.37 | 21.93 | 6 | 16806 | 185697 | 42418826 |
| Manic symptom | 47.52 | 21.93 | 12 | 16800 | 203 | 42604320 |
| Coordination abnormal | 47.46 | 21.93 | 33 | 16779 | 8017 | 42596506 |
| Growth hormone-producing pituitary tumour | 46.61 | 21.93 | 11 | 16801 | 138 | 42604385 |
| Hepatic enzyme increased | 45.72 | 21.93 | 72 | 16740 | 45712 | 42558811 |
| Affect lability | 45.41 | 21.93 | 25 | 16787 | 4019 | 42600504 |
| Disease progression | 44.94 | 21.93 | 3 | 16809 | 143653 | 42460870 |
| Gilbert's syndrome | 44.14 | 21.93 | 8 | 16804 | 22 | 42604501 |
| Headache | 44.11 | 21.93 | 199 | 16613 | 239170 | 42365353 |
| Thrombocytopenia | 43.05 | 21.93 | 11 | 16801 | 190268 | 42414255 |
| Gastric hypomotility | 42.56 | 21.93 | 11 | 16801 | 205 | 42604318 |
| Growth retardation | 41.72 | 21.93 | 20 | 16792 | 2412 | 42602111 |
| Social avoidant behaviour | 41.12 | 21.93 | 22 | 16790 | 3342 | 42601181 |
| Shunt malfunction | 39.69 | 21.93 | 11 | 16801 | 270 | 42604253 |
| Loss of consciousness | 39.58 | 21.93 | 102 | 16710 | 92252 | 42512271 |
| Screaming | 39.56 | 21.93 | 18 | 16794 | 1929 | 42602594 |
| Sexual dysfunction | 38.14 | 21.93 | 27 | 16785 | 6748 | 42597775 |
| Viral diarrhoea | 38.07 | 21.93 | 11 | 16801 | 315 | 42604208 |
| General physical health deterioration | 37.74 | 21.93 | 7 | 16805 | 151239 | 42453284 |
| Panic attack | 36.19 | 21.93 | 32 | 16780 | 11013 | 42593510 |
| Blood bilirubin increased | 36.18 | 21.93 | 62 | 16750 | 42190 | 42562333 |
| Trichotillomania | 35.47 | 21.93 | 8 | 16804 | 81 | 42604442 |
| Physical assault | 35.30 | 21.93 | 14 | 16798 | 1068 | 42603455 |
| Completed suicide | 34.79 | 21.93 | 100 | 16712 | 96365 | 42508158 |
| Chest pain | 34.39 | 21.93 | 127 | 16685 | 139403 | 42465120 |
| Pallor | 33.91 | 21.93 | 49 | 16763 | 28837 | 42575686 |
| Urinary retention | 33.62 | 21.93 | 60 | 16752 | 42154 | 42562369 |
| Spontaneous ejaculation | 33.52 | 21.93 | 6 | 16806 | 15 | 42604508 |
| Reversible cerebral vasoconstriction syndrome | 32.89 | 21.93 | 12 | 16800 | 728 | 42603795 |
| Personality change | 32.67 | 21.93 | 23 | 16789 | 5696 | 42598827 |
| Thinking abnormal | 32.35 | 21.93 | 25 | 16787 | 7136 | 42597387 |
| Hyperkinesia | 32.22 | 21.93 | 16 | 16796 | 2082 | 42602441 |
| Paranoia | 31.49 | 21.93 | 33 | 16779 | 13993 | 42590530 |
| Cardiac failure | 31.27 | 21.93 | 3 | 16809 | 106853 | 42497670 |
| Fight in school | 31.26 | 21.93 | 5 | 16807 | 4 | 42604519 |
| Renal failure | 31.20 | 21.93 | 9 | 16803 | 143717 | 42460806 |
| Syncope | 31.08 | 21.93 | 98 | 16714 | 99308 | 42505215 |
| Negativism | 30.92 | 21.93 | 10 | 16802 | 421 | 42604102 |
| Enuresis | 30.89 | 21.93 | 17 | 16795 | 2731 | 42601792 |
| Hyperhidrosis | 30.88 | 21.93 | 92 | 16720 | 90420 | 42514103 |
| Apathy | 30.88 | 21.93 | 26 | 16786 | 8380 | 42596143 |
| Blood growth hormone increased | 30.71 | 21.93 | 11 | 16801 | 633 | 42603890 |
| Vomiting | 30.51 | 21.93 | 207 | 16605 | 289516 | 42315007 |
| Repetitive speech | 30.26 | 21.93 | 7 | 16805 | 80 | 42604443 |
| Decreased appetite | 30.05 | 21.93 | 153 | 16659 | 192984 | 42411539 |
| Scrotal pain | 29.82 | 21.93 | 12 | 16800 | 951 | 42603572 |
| Pyromania | 29.81 | 21.93 | 6 | 16806 | 33 | 42604490 |
| Speech disorder | 29.35 | 21.93 | 46 | 16766 | 29075 | 42575448 |
| Hyponatraemia | 29.29 | 21.93 | 3 | 16809 | 101459 | 42503064 |
| Pulmonary embolism | 28.86 | 21.93 | 6 | 16806 | 119606 | 42484917 |
| Hostility | 28.21 | 21.93 | 11 | 16801 | 802 | 42603721 |
| Abdominal pain upper | 28.21 | 21.93 | 84 | 16728 | 82525 | 42521998 |
| Respiratory failure | 27.85 | 21.93 | 8 | 16804 | 128124 | 42476399 |
| Feeling jittery | 27.83 | 21.93 | 19 | 16793 | 4479 | 42600044 |
| Restlessness | 27.82 | 21.93 | 45 | 16767 | 29204 | 42575319 |
| Tearfulness | 27.07 | 21.93 | 17 | 16795 | 3483 | 42601040 |
| Raynaud's phenomenon | 26.63 | 21.93 | 8 | 16804 | 263 | 42604260 |
| Poor quality sleep | 26.34 | 21.93 | 25 | 16787 | 9415 | 42595108 |
| Asthenia | 26.27 | 21.93 | 44 | 16768 | 280749 | 42323774 |
| Eye movement disorder | 26.21 | 21.93 | 19 | 16793 | 4926 | 42599597 |
| Breath odour | 25.98 | 21.93 | 11 | 16801 | 992 | 42603531 |
| Pyrexia | 25.97 | 21.93 | 75 | 16737 | 393967 | 42210556 |
| Shunt occlusion | 25.73 | 21.93 | 11 | 16801 | 1016 | 42603507 |
| Tourette's disorder | 25.67 | 21.93 | 6 | 16806 | 72 | 42604451 |
| Dysphoria | 25.34 | 21.93 | 15 | 16797 | 2765 | 42601758 |
| Peripheral swelling | 25.22 | 21.93 | 3 | 16809 | 90267 | 42514256 |
| Hallucination, visual | 25.17 | 21.93 | 36 | 16776 | 20984 | 42583539 |
| Strabismus | 24.95 | 21.93 | 14 | 16798 | 2334 | 42602189 |
| School refusal | 24.62 | 21.93 | 5 | 16807 | 29 | 42604494 |
| Erectile dysfunction | 24.61 | 21.93 | 39 | 16773 | 24874 | 42579649 |
| Dyspnoea | 24.51 | 21.93 | 91 | 16721 | 442530 | 42161993 |
| Infrequent bowel movements | 24.42 | 21.93 | 11 | 16801 | 1151 | 42603372 |
| Amphetamines positive | 24.28 | 21.93 | 7 | 16805 | 199 | 42604324 |
| Pain | 24.19 | 21.93 | 37 | 16775 | 244811 | 42359712 |
| Semen analysis abnormal | 23.94 | 21.93 | 5 | 16807 | 34 | 42604489 |
| Drooling | 23.89 | 21.93 | 17 | 16795 | 4282 | 42600241 |
| Weight increased | 23.88 | 21.93 | 95 | 16717 | 107888 | 42496635 |
| Insulin-like growth factor increased | 23.76 | 21.93 | 12 | 16800 | 1619 | 42602904 |
| Oedema peripheral | 23.75 | 21.93 | 12 | 16800 | 136064 | 42468459 |
| Obsessive-compulsive symptom | 23.45 | 21.93 | 7 | 16805 | 225 | 42604298 |
| Gastrointestinal haemorrhage | 23.37 | 21.93 | 5 | 16807 | 97721 | 42506802 |
| Streptococcal infection | 22.59 | 21.93 | 19 | 16793 | 6113 | 42598410 |
| Infection | 22.57 | 21.93 | 8 | 16804 | 112060 | 42492463 |
| Arthralgia | 22.27 | 21.93 | 29 | 16783 | 205209 | 42399314 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blepharospasm | 863.87 | 22.55 | 530 | 82982 | 54321 | 110451466 |
| Epilepsy | 666.21 | 22.55 | 574 | 82938 | 99635 | 110406152 |
| Taste disorder | 650.78 | 22.55 | 475 | 83037 | 64912 | 110440875 |
| Onychomadesis | 632.94 | 22.55 | 407 | 83105 | 45256 | 110460531 |
| Nail disorder | 620.34 | 22.55 | 440 | 83072 | 57495 | 110448292 |
| Breast cancer stage III | 574.72 | 22.55 | 477 | 83035 | 78640 | 110427147 |
| Tic | 549.35 | 22.55 | 172 | 83340 | 3321 | 110502466 |
| Facet joint syndrome | 529.69 | 22.55 | 497 | 83015 | 96331 | 110409456 |
| Hypercholesterolaemia | 486.80 | 22.55 | 461 | 83051 | 90376 | 110415411 |
| Back injury | 482.16 | 22.55 | 349 | 83163 | 47050 | 110458737 |
| Onychomycosis | 445.92 | 22.55 | 307 | 83205 | 38224 | 110467563 |
| Product quality issue | 419.31 | 22.55 | 395 | 83117 | 76904 | 110428883 |
| Lip dry | 407.96 | 22.55 | 438 | 83074 | 99645 | 110406142 |
| Peripheral venous disease | 407.63 | 22.55 | 404 | 83108 | 83713 | 110422074 |
| Wound infection | 398.18 | 22.55 | 425 | 83087 | 96040 | 110409747 |
| Suicidal ideation | 393.29 | 22.55 | 417 | 83095 | 93520 | 110412267 |
| Acute kidney injury | 391.29 | 22.55 | 22 | 83490 | 635408 | 109870379 |
| Bursitis | 373.15 | 22.55 | 475 | 83037 | 129443 | 110376344 |
| Type 2 diabetes mellitus | 369.30 | 22.55 | 555 | 82957 | 176677 | 110329110 |
| Product label confusion | 346.34 | 22.55 | 215 | 83297 | 22462 | 110483325 |
| Gastrooesophageal reflux disease | 336.34 | 22.55 | 536 | 82976 | 179440 | 110326347 |
| Psoriatic arthropathy | 328.61 | 22.55 | 557 | 82955 | 196204 | 110309583 |
| Aggression | 327.66 | 22.55 | 306 | 83206 | 58904 | 110446883 |
| Muscle injury | 325.25 | 22.55 | 463 | 83049 | 140344 | 110365443 |
| Anaemia | 324.62 | 22.55 | 23 | 83489 | 547063 | 109958724 |
| Obesity | 321.64 | 22.55 | 412 | 83100 | 112939 | 110392848 |
| Live birth | 318.75 | 22.55 | 324 | 83188 | 69160 | 110436627 |
| Liver injury | 314.69 | 22.55 | 472 | 83040 | 149941 | 110355846 |
| Prescribed overdose | 309.86 | 22.55 | 356 | 83156 | 87225 | 110418562 |
| Folliculitis | 308.72 | 22.55 | 496 | 83016 | 167157 | 110338630 |
| Grip strength decreased | 302.54 | 22.55 | 337 | 83175 | 79837 | 110425950 |
| Helicobacter infection | 286.79 | 22.55 | 502 | 83010 | 181375 | 110324412 |
| Fibromyalgia | 281.60 | 22.55 | 481 | 83031 | 170428 | 110335359 |
| Memory impairment | 279.20 | 22.55 | 519 | 82993 | 196425 | 110309362 |
| Pericarditis | 278.20 | 22.55 | 551 | 82961 | 218563 | 110287224 |
| Pemphigus | 272.93 | 22.55 | 540 | 82972 | 214030 | 110291757 |
| Adverse reaction | 271.88 | 22.55 | 205 | 83307 | 29389 | 110476398 |
| Blood cholesterol increased | 268.27 | 22.55 | 492 | 83020 | 184293 | 110321494 |
| Duodenal ulcer perforation | 267.96 | 22.55 | 481 | 83031 | 177219 | 110328568 |
| Finger deformity | 257.96 | 22.55 | 208 | 83304 | 32884 | 110472903 |
| Coeliac disease | 256.04 | 22.55 | 232 | 83280 | 42955 | 110462832 |
| Joint range of motion decreased | 254.33 | 22.55 | 382 | 83130 | 121450 | 110384337 |
| Gait inability | 251.73 | 22.55 | 404 | 83108 | 135972 | 110369815 |
| Irritable bowel syndrome | 250.78 | 22.55 | 447 | 83065 | 163768 | 110342019 |
| Depression | 250.37 | 22.55 | 661 | 82851 | 316674 | 110189113 |
| Hand deformity | 247.27 | 22.55 | 524 | 82988 | 217982 | 110287805 |
| Dry mouth | 242.05 | 22.55 | 493 | 83019 | 199455 | 110306332 |
| C-reactive protein increased | 240.15 | 22.55 | 517 | 82995 | 217402 | 110288385 |
| Anti-cyclic citrullinated peptide antibody positive | 237.44 | 22.55 | 463 | 83049 | 181521 | 110324266 |
| Rheumatic fever | 237.08 | 22.55 | 371 | 83141 | 122208 | 110383579 |
| Night sweats | 236.54 | 22.55 | 389 | 83123 | 133594 | 110372193 |
| Systemic lupus erythematosus | 231.06 | 22.55 | 559 | 82953 | 253779 | 110252008 |
| Glossodynia | 229.11 | 22.55 | 513 | 82999 | 221491 | 110284296 |
| Osteoarthritis | 226.65 | 22.55 | 455 | 83057 | 182168 | 110323619 |
| Abnormal behaviour | 226.11 | 22.55 | 207 | 83305 | 38832 | 110466955 |
| Pyrexia | 221.07 | 22.55 | 212 | 83300 | 898053 | 109607734 |
| Inflammation | 219.29 | 22.55 | 464 | 83048 | 192774 | 110313013 |
| Impaired healing | 215.91 | 22.55 | 466 | 83046 | 196251 | 110309536 |
| Wound | 213.72 | 22.55 | 516 | 82996 | 233921 | 110271866 |
| Maternal exposure during pregnancy | 212.34 | 22.55 | 542 | 82970 | 254341 | 110251446 |
| Sepsis | 208.72 | 22.55 | 9 | 83503 | 327337 | 110178450 |
| Hypoaesthesia | 205.98 | 22.55 | 612 | 82900 | 313611 | 110192176 |
| Sleep disorder | 204.91 | 22.55 | 459 | 83053 | 198185 | 110307602 |
| Febrile neutropenia | 204.35 | 22.55 | 8 | 83504 | 316759 | 110189028 |
| Death | 204.22 | 22.55 | 139 | 83373 | 698730 | 109807057 |
| Abdominal pain upper | 196.59 | 22.55 | 645 | 82867 | 348466 | 110157321 |
| Thrombocytopenia | 194.86 | 22.55 | 19 | 83493 | 348866 | 110156921 |
| Lung disorder | 190.15 | 22.55 | 420 | 83092 | 179627 | 110326160 |
| Musculoskeletal pain | 184.39 | 22.55 | 419 | 83093 | 182604 | 110323183 |
| Paraesthesia | 176.85 | 22.55 | 534 | 82978 | 275987 | 110229800 |
| Synovitis | 175.00 | 22.55 | 529 | 82983 | 273563 | 110232224 |
| Infusion site reaction | 174.75 | 22.55 | 128 | 83384 | 17554 | 110488233 |
| Anger | 170.90 | 22.55 | 130 | 83382 | 18877 | 110486910 |
| Injection site reaction | 169.99 | 22.55 | 268 | 83244 | 88802 | 110416985 |
| Hypotension | 169.95 | 22.55 | 92 | 83420 | 523757 | 109982030 |
| Neutropenia | 168.97 | 22.55 | 38 | 83474 | 374582 | 110131205 |
| Neck pain | 168.78 | 22.55 | 320 | 83192 | 122810 | 110382977 |
| Disease progression | 165.16 | 22.55 | 4 | 83508 | 244030 | 110261757 |
| Irritability | 165.10 | 22.55 | 192 | 83320 | 47617 | 110458170 |
| Lower respiratory tract infection | 164.49 | 22.55 | 479 | 83033 | 242627 | 110263160 |
| Liver function test increased | 164.26 | 22.55 | 263 | 83249 | 88285 | 110417502 |
| Rheumatoid arthritis | 160.11 | 22.55 | 544 | 82968 | 299069 | 110206718 |
| Oppositional defiant disorder | 159.49 | 22.55 | 43 | 83469 | 475 | 110505312 |
| C-reactive protein abnormal | 152.38 | 22.55 | 316 | 83196 | 129379 | 110376408 |
| Back pain | 149.58 | 22.55 | 47 | 83465 | 370949 | 110134838 |
| Arthropathy | 146.60 | 22.55 | 514 | 82998 | 287008 | 110218779 |
| Dyspepsia | 145.58 | 22.55 | 393 | 83119 | 190572 | 110315215 |
| Ill-defined disorder | 142.59 | 22.55 | 345 | 83167 | 156508 | 110349279 |
| Blister | 142.42 | 22.55 | 436 | 83076 | 226940 | 110278847 |
| Psychomotor hyperactivity | 138.34 | 22.55 | 118 | 83394 | 20159 | 110485628 |
| Urinary tract infection | 135.76 | 22.55 | 39 | 83473 | 326243 | 110179544 |
| Renal failure | 132.86 | 22.55 | 10 | 83502 | 226564 | 110279223 |
| Hepatic enzyme increased | 132.35 | 22.55 | 536 | 82976 | 320356 | 110185431 |
| Cough | 130.49 | 22.55 | 95 | 83417 | 461546 | 110044241 |
| Muscle spasms | 128.84 | 22.55 | 482 | 83030 | 277675 | 110228112 |
| Abdominal discomfort | 127.62 | 22.55 | 612 | 82900 | 393246 | 110112541 |
| Hyponatraemia | 126.51 | 22.55 | 10 | 83502 | 217643 | 110288144 |
| Overlap syndrome | 126.07 | 22.55 | 81 | 83431 | 8978 | 110496809 |
| Swelling | 125.93 | 22.55 | 562 | 82950 | 350479 | 110155308 |
| Wheezing | 125.55 | 22.55 | 451 | 83061 | 254779 | 110251008 |
| Intentional self-injury | 123.73 | 22.55 | 147 | 83365 | 37282 | 110468505 |
| Contraindicated product administered | 123.23 | 22.55 | 440 | 83072 | 247827 | 110257960 |
| Ejaculation disorder | 122.93 | 22.55 | 36 | 83476 | 548 | 110505239 |
| Dehydration | 122.74 | 22.55 | 30 | 83482 | 279481 | 110226306 |
| Normal newborn | 122.70 | 22.55 | 114 | 83398 | 21782 | 110484005 |
| Intentional product use issue | 121.89 | 22.55 | 438 | 83074 | 247468 | 110258319 |
| Haemoglobin decreased | 118.81 | 22.55 | 22 | 83490 | 248705 | 110257082 |
| Drug-induced liver injury | 118.78 | 22.55 | 273 | 83239 | 119794 | 110385993 |
| Renal impairment | 117.42 | 22.55 | 6 | 83506 | 188439 | 110317348 |
| Pulmonary embolism | 113.82 | 22.55 | 14 | 83498 | 214460 | 110291327 |
| Hepatitis | 112.37 | 22.55 | 225 | 83287 | 89829 | 110415958 |
| Pruritus | 111.14 | 22.55 | 167 | 83345 | 581393 | 109924394 |
| Neuropathy peripheral | 110.78 | 22.55 | 6 | 83506 | 179271 | 110326516 |
| Erythema | 110.38 | 22.55 | 41 | 83471 | 291406 | 110214381 |
| Stomatitis | 108.70 | 22.55 | 448 | 83064 | 269794 | 110235993 |
| Respiratory failure | 107.35 | 22.55 | 17 | 83495 | 215315 | 110290472 |
| Drug abuse | 103.52 | 22.55 | 8 | 83504 | 177403 | 110328384 |
| COVID-19 | 102.46 | 22.55 | 29 | 83483 | 245031 | 110260756 |
| Therapeutic product effect decreased | 101.40 | 22.55 | 409 | 83103 | 243907 | 110261880 |
| Homicidal ideation | 100.89 | 22.55 | 51 | 83461 | 3576 | 110502211 |
| Gastrointestinal haemorrhage | 100.86 | 22.55 | 6 | 83506 | 165512 | 110340275 |
| Crying | 100.54 | 22.55 | 110 | 83402 | 25518 | 110480269 |
| Pneumonia | 100.18 | 22.55 | 334 | 83178 | 876380 | 109629407 |
| Exposure during pregnancy | 100.12 | 22.55 | 316 | 83196 | 167108 | 110338679 |
| Hepatic enzyme | 99.81 | 22.55 | 57 | 83455 | 5106 | 110500681 |
| White blood cell count decreased | 98.05 | 22.55 | 26 | 83486 | 229364 | 110276423 |
| Alopecia | 98.04 | 22.55 | 538 | 82974 | 364215 | 110141572 |
| Abdominal distension | 97.92 | 22.55 | 323 | 83189 | 174780 | 110331007 |
| Confusional state | 97.15 | 22.55 | 646 | 82866 | 468034 | 110037753 |
| Mood swings | 96.68 | 22.55 | 102 | 83410 | 22710 | 110483077 |
| Platelet count decreased | 94.99 | 22.55 | 28 | 83484 | 230415 | 110275372 |
| Cardiac failure congestive | 93.47 | 22.55 | 5 | 83507 | 150995 | 110354792 |
| Impulsive behaviour | 93.34 | 22.55 | 47 | 83465 | 3268 | 110502519 |
| Injury | 90.35 | 22.55 | 317 | 83195 | 176948 | 110328839 |
| Blood creatinine increased | 89.90 | 22.55 | 15 | 83497 | 182874 | 110322913 |
| Myocardial infarction | 89.59 | 22.55 | 18 | 83494 | 192065 | 110313722 |
| Constipation | 89.43 | 22.55 | 83 | 83429 | 357703 | 110148084 |
| Hyperkalaemia | 85.63 | 22.55 | 4 | 83508 | 135792 | 110369995 |
| Diarrhoea | 84.99 | 22.55 | 509 | 83003 | 1138996 | 109366791 |
| Mobility decreased | 83.47 | 22.55 | 378 | 83134 | 237044 | 110268743 |
| Infusion related reaction | 82.98 | 22.55 | 532 | 82980 | 380630 | 110125157 |
| Urticaria | 82.12 | 22.55 | 465 | 83047 | 318392 | 110187395 |
| Educational problem | 82.07 | 22.55 | 26 | 83486 | 522 | 110505265 |
| Testicular pain | 82.06 | 22.55 | 39 | 83473 | 2390 | 110503397 |
| Dyspnoea | 80.65 | 22.55 | 498 | 83014 | 1106374 | 109399413 |
| Hypokalaemia | 79.26 | 22.55 | 20 | 83492 | 182428 | 110323359 |
| Hypoxia | 77.99 | 22.55 | 5 | 83507 | 129510 | 110376277 |
| Cardiac failure | 73.40 | 22.55 | 25 | 83487 | 187601 | 110318186 |
| Decreased eye contact | 72.66 | 22.55 | 27 | 83485 | 888 | 110504899 |
| Insomnia | 72.24 | 22.55 | 493 | 83019 | 360097 | 110145690 |
| Attention deficit hyperactivity disorder | 72.17 | 22.55 | 44 | 83468 | 4447 | 110501340 |
| Cerebrovascular accident | 69.46 | 22.55 | 25 | 83487 | 181259 | 110324528 |
| Atrial fibrillation | 69.17 | 22.55 | 44 | 83468 | 229598 | 110276189 |
| Weight increased | 68.81 | 22.55 | 547 | 82965 | 419097 | 110086690 |
| Agitation | 68.13 | 22.55 | 214 | 83298 | 112837 | 110392950 |
| Pleural effusion | 67.26 | 22.55 | 25 | 83487 | 177684 | 110328103 |
| Herpes zoster | 65.81 | 22.55 | 4 | 83508 | 108375 | 110397412 |
| Urinary hesitation | 65.68 | 22.55 | 42 | 83470 | 4616 | 110501171 |
| Chills | 65.40 | 22.55 | 31 | 83481 | 190549 | 110315238 |
| Infection | 65.32 | 22.55 | 108 | 83404 | 362092 | 110143695 |
| Drug intolerance | 65.07 | 22.55 | 527 | 82985 | 405985 | 110099802 |
| Cellulitis | 64.98 | 22.55 | 9 | 83503 | 126007 | 110379780 |
| Arthritis | 64.40 | 22.55 | 23 | 83489 | 167563 | 110338224 |
| Disturbance in attention | 63.55 | 22.55 | 143 | 83369 | 61852 | 110443935 |
| Chronic obstructive pulmonary disease | 63.45 | 22.55 | 5 | 83507 | 109153 | 110396634 |
| Trichotillomania | 63.37 | 22.55 | 17 | 83495 | 184 | 110505603 |
| Drug interaction | 63.06 | 22.55 | 182 | 83330 | 500001 | 110005786 |
| Mania | 62.74 | 22.55 | 78 | 83434 | 20718 | 110485069 |
| Productive cough | 61.77 | 22.55 | 7 | 83505 | 114298 | 110391489 |
| Gastrointestinal disorder | 60.39 | 22.55 | 350 | 83162 | 241602 | 110264185 |
| Deep vein thrombosis | 59.49 | 22.55 | 16 | 83496 | 139871 | 110365916 |
| Colitis | 58.61 | 22.55 | 5 | 83507 | 102318 | 110403469 |
| Multiple organ dysfunction syndrome | 57.99 | 22.55 | 21 | 83491 | 151689 | 110354098 |
| Hypocholesterolaemia | 57.90 | 22.55 | 44 | 83468 | 6377 | 110499410 |
| Neutrophil count decreased | 57.09 | 22.55 | 11 | 83501 | 120930 | 110384857 |
| Anaphylactic reaction | 57.00 | 22.55 | 9 | 83503 | 114291 | 110391496 |
| Metabolic acidosis | 56.79 | 22.55 | 5 | 83507 | 99739 | 110406048 |
| Product tampering | 56.63 | 22.55 | 19 | 83493 | 460 | 110505327 |
| Chest discomfort | 55.60 | 22.55 | 31 | 83481 | 173817 | 110331970 |
| Product dose omission issue | 55.23 | 22.55 | 99 | 83413 | 321683 | 110184104 |
| Toxicity to various agents | 54.80 | 22.55 | 183 | 83329 | 480372 | 110025415 |
| Underdose | 54.74 | 22.55 | 137 | 83375 | 63417 | 110442370 |
| Balance disorder | 52.14 | 22.55 | 12 | 83500 | 116548 | 110389239 |
| Ascites | 51.91 | 22.55 | 5 | 83507 | 92803 | 110412984 |
| Treatment failure | 51.36 | 22.55 | 372 | 83140 | 276862 | 110228925 |
| Thrombosis | 51.04 | 22.55 | 10 | 83502 | 108652 | 110397135 |
| Bradycardia | 50.80 | 22.55 | 27 | 83485 | 155490 | 110350297 |
| General physical health deterioration | 50.53 | 22.55 | 517 | 82995 | 424778 | 110081009 |
| Oedema peripheral | 50.45 | 22.55 | 108 | 83404 | 328552 | 110177235 |
| International normalised ratio increased | 50.36 | 22.55 | 4 | 83508 | 86768 | 110419019 |
| Haematochezia | 49.52 | 22.55 | 13 | 83499 | 115511 | 110390276 |
| Rhabdomyolysis | 48.93 | 22.55 | 15 | 83497 | 120386 | 110385401 |
| Pulmonary oedema | 47.84 | 22.55 | 9 | 83503 | 100650 | 110405137 |
| Breast cancer stage II | 47.60 | 22.55 | 79 | 83433 | 27296 | 110478491 |
| Obsessive-compulsive disorder | 47.08 | 22.55 | 41 | 83471 | 7200 | 110498587 |
| Hypertension | 45.73 | 22.55 | 587 | 82925 | 509497 | 109996290 |
| Acute respiratory failure | 45.03 | 22.55 | 3 | 83509 | 75257 | 110430530 |
| Oropharyngeal pain | 44.90 | 22.55 | 23 | 83489 | 135253 | 110370534 |
| Angioedema | 44.34 | 22.55 | 10 | 83502 | 98490 | 110407297 |
| Penile discharge | 44.01 | 22.55 | 10 | 83502 | 50 | 110505737 |
| Myalgia | 43.23 | 22.55 | 63 | 83449 | 222318 | 110283469 |
| Chronic kidney disease | 42.96 | 22.55 | 4 | 83508 | 76287 | 110429500 |
| Influenza | 42.49 | 22.55 | 39 | 83473 | 169062 | 110336725 |
| Therapeutic product effect incomplete | 42.42 | 22.55 | 302 | 83210 | 223503 | 110282284 |
| Bruxism | 42.36 | 22.55 | 33 | 83479 | 4961 | 110500826 |
| Inappropriate schedule of product administration | 42.29 | 22.55 | 55 | 83457 | 203582 | 110302205 |
| Hyperglycaemia | 41.76 | 22.55 | 7 | 83505 | 85083 | 110420704 |
| Injection site erythema | 41.52 | 22.55 | 10 | 83502 | 94166 | 110411621 |
| Diabetes mellitus | 41.07 | 22.55 | 12 | 83500 | 99369 | 110406418 |
| Vertigo | 40.79 | 22.55 | 8 | 83504 | 86862 | 110418925 |
| Coma | 40.70 | 22.55 | 19 | 83493 | 117850 | 110387937 |
| Haemorrhage | 40.38 | 22.55 | 15 | 83497 | 106677 | 110399110 |
| Dysphonia | 40.16 | 22.55 | 5 | 83507 | 75924 | 110429863 |
| Fall | 40.01 | 22.55 | 279 | 83233 | 603203 | 109902584 |
| Product use issue | 39.95 | 22.55 | 385 | 83127 | 311310 | 110194477 |
| Self-injurious ideation | 39.67 | 22.55 | 30 | 83482 | 4316 | 110501471 |
| Hallucination, auditory | 39.14 | 22.55 | 71 | 83441 | 26326 | 110479461 |
| Growth hormone-producing pituitary tumour | 39.09 | 22.55 | 11 | 83501 | 144 | 110505643 |
| Dystonia | 39.02 | 22.55 | 70 | 83442 | 25735 | 110480052 |
| Choreoathetosis | 39.00 | 22.55 | 21 | 83491 | 1677 | 110504110 |
| Rash maculo-papular | 38.98 | 22.55 | 5 | 83507 | 74217 | 110431570 |
| Hypoglycaemia | 38.15 | 22.55 | 20 | 83492 | 116084 | 110389703 |
| Product use in unapproved indication | 37.64 | 22.55 | 509 | 83003 | 446868 | 110058919 |
| Claustrophobia | 37.59 | 22.55 | 20 | 83492 | 1559 | 110504228 |
| Suicide attempt | 37.33 | 22.55 | 166 | 83346 | 103228 | 110402559 |
| Blood pressure fluctuation | 37.06 | 22.55 | 6 | 83506 | 74818 | 110430969 |
| Pneumonia aspiration | 37.06 | 22.55 | 8 | 83504 | 81225 | 110424562 |
| Haemoptysis | 37.01 | 22.55 | 5 | 83507 | 71349 | 110434438 |
| Transient ischaemic attack | 36.99 | 22.55 | 3 | 83509 | 63979 | 110441808 |
| Product substitution issue | 36.73 | 22.55 | 64 | 83448 | 22997 | 110482790 |
| Rhinorrhoea | 36.30 | 22.55 | 16 | 83496 | 102650 | 110403137 |
| Haematuria | 36.23 | 22.55 | 9 | 83503 | 82996 | 110422791 |
| Manic symptom | 36.02 | 22.55 | 12 | 83500 | 284 | 110505503 |
| Injection site pain | 35.98 | 22.55 | 49 | 83463 | 177873 | 110327914 |
| Adverse event | 35.81 | 22.55 | 170 | 83342 | 108639 | 110397148 |
| Gastric hypomotility | 35.67 | 22.55 | 12 | 83500 | 293 | 110505494 |
| Skin exfoliation | 35.47 | 22.55 | 11 | 83501 | 87640 | 110418147 |
| Respiratory distress | 35.31 | 22.55 | 5 | 83507 | 68869 | 110436918 |
| Acute myocardial infarction | 34.83 | 22.55 | 10 | 83502 | 83767 | 110422020 |
| Weight decreased | 34.77 | 22.55 | 209 | 83303 | 467848 | 110037939 |
| Dry skin | 34.70 | 22.55 | 19 | 83493 | 107634 | 110398153 |
| Adulterated product | 34.36 | 22.55 | 17 | 83495 | 1138 | 110504649 |
| Nasopharyngitis | 34.13 | 22.55 | 451 | 83061 | 393910 | 110111877 |
| Oxygen saturation decreased | 34.05 | 22.55 | 41 | 83471 | 156941 | 110348846 |
| Blood glucose increased | 33.95 | 22.55 | 30 | 83482 | 132466 | 110373321 |
| Suicidal behaviour | 33.84 | 22.55 | 25 | 83487 | 3472 | 110502315 |
| Cognitive disorder | 33.63 | 22.55 | 12 | 83500 | 87499 | 110418288 |
| Hypothyroidism | 33.63 | 22.55 | 7 | 83505 | 72892 | 110432895 |
| Rash erythematous | 33.60 | 22.55 | 10 | 83502 | 81822 | 110423965 |
| Gilbert's syndrome | 33.39 | 22.55 | 7 | 83505 | 22 | 110505765 |
| Growth retardation | 33.27 | 22.55 | 22 | 83490 | 2560 | 110503227 |
| Respiratory tract infection | 32.78 | 22.55 | 7 | 83505 | 71610 | 110434177 |
| Bone marrow failure | 32.66 | 22.55 | 3 | 83509 | 57845 | 110447942 |
| Cholestasis | 32.35 | 22.55 | 5 | 83507 | 64513 | 110441274 |
| Dislocation of vertebra | 32.29 | 22.55 | 89 | 83423 | 43632 | 110462155 |
| Disease recurrence | 32.15 | 22.55 | 4 | 83508 | 60780 | 110445007 |
| Leukopenia | 32.13 | 22.55 | 39 | 83473 | 148752 | 110357035 |
| Lower limb fracture | 31.90 | 22.55 | 127 | 83385 | 75221 | 110430566 |
| Mental status changes | 31.81 | 22.55 | 9 | 83503 | 76113 | 110429674 |
| Somatic symptom disorder | 31.51 | 22.55 | 23 | 83489 | 3136 | 110502651 |
| Hepatic function abnormal | 31.44 | 22.55 | 14 | 83498 | 89281 | 110416506 |
| Drug screen positive | 31.41 | 22.55 | 31 | 83481 | 6379 | 110499408 |
| Psychotic disorder | 31.21 | 22.55 | 97 | 83415 | 50840 | 110454947 |
| Cystitis | 31.17 | 22.55 | 6 | 83506 | 66030 | 110439757 |
| Red blood cell count decreased | 31.10 | 22.55 | 6 | 83506 | 65917 | 110439870 |
| Mood altered | 31.07 | 22.55 | 57 | 83455 | 21318 | 110484469 |
| Coronary artery disease | 30.85 | 22.55 | 8 | 83504 | 71682 | 110434105 |
| Mydriasis | 30.84 | 22.55 | 58 | 83454 | 22099 | 110483688 |
| Blood urea increased | 30.63 | 22.55 | 3 | 83509 | 54954 | 110450833 |
| Haematoma | 30.56 | 22.55 | 4 | 83508 | 58472 | 110447315 |
| School refusal | 30.49 | 22.55 | 7 | 83505 | 37 | 110505750 |
| Dysphagia | 30.35 | 22.55 | 43 | 83469 | 153557 | 110352230 |
| Upper respiratory tract infection | 29.89 | 22.55 | 33 | 83479 | 131295 | 110374492 |
| Staphylococcal infection | 29.73 | 22.55 | 8 | 83504 | 69936 | 110435851 |
| Shunt malfunction | 29.68 | 22.55 | 11 | 83501 | 359 | 110505428 |
| Spontaneous ejaculation | 29.63 | 22.55 | 6 | 83506 | 15 | 110505772 |
| Skin ulcer | 29.59 | 22.55 | 6 | 83506 | 63639 | 110442148 |
| Pancreatitis acute | 29.48 | 22.55 | 5 | 83507 | 60269 | 110445518 |
| Burning sensation | 29.26 | 22.55 | 8 | 83504 | 69204 | 110436583 |
| Blood pressure systolic increased | 29.24 | 22.55 | 13 | 83499 | 82978 | 110422809 |
| Sinusitis | 29.19 | 22.55 | 120 | 83392 | 296568 | 110209219 |
| Bone pain | 28.55 | 22.55 | 7 | 83505 | 65126 | 110440661 |
| Cerebral infarction | 28.45 | 22.55 | 3 | 83509 | 51835 | 110453952 |
| Bipolar I disorder | 28.32 | 22.55 | 19 | 83493 | 2264 | 110503523 |
| Social avoidant behaviour | 28.25 | 22.55 | 27 | 83485 | 5342 | 110500445 |
| Injection site bruising | 28.05 | 22.55 | 3 | 83509 | 51260 | 110454527 |
| Pulse abnormal | 28 | 22.55 | 24 | 83488 | 4125 | 110501662 |
| Lip swelling | 27.63 | 22.55 | 3 | 83509 | 50664 | 110455123 |
| Heart rate decreased | 27.56 | 22.55 | 14 | 83498 | 82742 | 110423045 |
| Swollen tongue | 27.43 | 22.55 | 6 | 83506 | 60356 | 110445431 |
| Haematocrit decreased | 27.29 | 22.55 | 8 | 83504 | 66109 | 110439678 |
| Therapy interrupted | 27.04 | 22.55 | 3 | 83509 | 49819 | 110455968 |
| Drug resistance | 26.87 | 22.55 | 5 | 83507 | 56369 | 110449418 |
| Cardiac disorder | 26.79 | 22.55 | 12 | 83500 | 76268 | 110429519 |
| Muscular weakness | 26.64 | 22.55 | 296 | 83216 | 248172 | 110257615 |
| Clostridium difficile infection | 26.23 | 22.55 | 4 | 83508 | 52125 | 110453662 |
| Lymphadenopathy | 25.85 | 22.55 | 8 | 83504 | 63827 | 110441960 |
| Tourette's disorder | 25.83 | 22.55 | 7 | 83505 | 79 | 110505708 |
| Cholelithiasis | 25.59 | 22.55 | 8 | 83504 | 63414 | 110442373 |
| Nephrolithiasis | 25.58 | 22.55 | 9 | 83503 | 66203 | 110439584 |
| Blood potassium decreased | 25.37 | 22.55 | 5 | 83507 | 54109 | 110451678 |
| Prescribed underdose | 25.33 | 22.55 | 107 | 83405 | 65067 | 110440720 |
| Rectal haemorrhage | 25.25 | 22.55 | 32 | 83480 | 119801 | 110385986 |
| Drug eruption | 25.07 | 22.55 | 5 | 83507 | 53654 | 110452133 |
| Scrotal pain | 24.84 | 22.55 | 11 | 83501 | 572 | 110505215 |
| Cerebral haemorrhage | 24.81 | 22.55 | 9 | 83503 | 64959 | 110440828 |
| Acute respiratory distress syndrome | 24.76 | 22.55 | 5 | 83507 | 53193 | 110452594 |
| Unevaluable event | 24.75 | 22.55 | 7 | 83505 | 59220 | 110446567 |
| Viral diarrhoea | 24.65 | 22.55 | 11 | 83501 | 583 | 110505204 |
| Paranoia | 24.50 | 22.55 | 53 | 83459 | 22321 | 110483466 |
| Physical assault | 23.75 | 22.55 | 15 | 83497 | 1613 | 110504174 |
| Bronchitis | 23.74 | 22.55 | 52 | 83460 | 156980 | 110348807 |
| Subcutaneous drug absorption impaired | 23.54 | 22.55 | 29 | 83483 | 7630 | 110498157 |
| Pain in jaw | 23.43 | 22.55 | 5 | 83507 | 51172 | 110454615 |
| Angina pectoris | 23.17 | 22.55 | 9 | 83503 | 62286 | 110443501 |
| Hepatocellular injury | 23.08 | 22.55 | 5 | 83507 | 50637 | 110455150 |
| Ulcer haemorrhage | 23.05 | 22.55 | 52 | 83460 | 22519 | 110483268 |
| Dysarthria | 22.84 | 22.55 | 18 | 83494 | 84103 | 110421684 |
| Multiple sclerosis relapse | 22.81 | 22.55 | 5 | 83507 | 50235 | 110455552 |
| X-ray abnormal | 22.81 | 22.55 | 72 | 83440 | 38045 | 110467742 |
| Peripheral swelling | 22.74 | 22.55 | 430 | 83082 | 403604 | 110102183 |
| Dry eye | 22.58 | 22.55 | 7 | 83505 | 55786 | 110450001 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BA09 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics |
| FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
| MeSH PA | D049990 | Membrane Transport Modulators |
| FDA EPC | N0000175695 | Norepinephrine Reuptake Inhibitor |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitor |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:50514 | vasoconstrictor agent |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
Related Drugs by ATC class:
N06BA Centrally acting sympathomimetics 14 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Attention deficit hyperactivity disorder | indication | 406506008 | |
| Delay when starting to pass urine | contraindication | 5972002 | |
| Priapism | contraindication | 6273006 | DOID:9286 |
| Suicidal thoughts | contraindication | 6471006 | |
| Sinus tachycardia | contraindication | 11092001 | |
| Bipolar disorder | contraindication | 13746004 | DOID:3312 |
| Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Feeling agitated | contraindication | 24199005 | |
| Orthostatic hypotension | contraindication | 28651003 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Feeling irritable | contraindication | 55929007 | |
| Aggressive behavior | contraindication | 61372001 | |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Psychotic disorder | contraindication | 69322001 | |
| Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
| Structural disorder of heart | contraindication | 128599005 | |
| Seizure disorder | contraindication | 128613002 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Mania | contraindication | 231494001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Raynaud's phenomenon | contraindication | 266261006 | |
| Retention of urine | contraindication | 267064002 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial infarction in recovery phase | contraindication | 418044006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.32 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 8.69 | CHEMBL | CHEMBL | |||
| Sodium-dependent serotonin transporter | Transporter | Kd | 8.05 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Kd | 5.97 | CHEMBL | |||||
| Cytochrome P450 2D6 | Enzyme | Ki | 4.77 | WOMBAT-PK | |||||
| G protein-activated inward rectifier potassium channel 2 | Ion channel | IC50 | 4.28 | WOMBAT-PK | |||||
| Kir3.1/Kir3.2 | Ion channel | IC50 | 4.48 | WOMBAT-PK | |||||
| Kir3.1/Kir3.4 | Ion channel | IC50 | 4.85 | WOMBAT-PK | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.68 | CHEMBL | |||||
| Krueppel-like factor 10 | Nuclear other | IC50 | 4 | CHEMBL | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 7.37 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.85 | CHEMBL | |||||
| Transporter | Transporter | Ki | 9.15 | CHEMBL | |||||
| Transporter | Transporter | Ki | 8.40 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02574 | KEGG_DRUG |
| 82248-59-7 | SECONDARY_CAS_RN |
| 353103 | RXNORM |
| C0076823 | UMLSCUI |
| CHEBI:127342 | CHEBI |
| CHEMBL641 | ChEMBL_ID |
| CHEMBL1702 | ChEMBL_ID |
| DB00289 | DRUGBANK_ID |
| D000069445 | MESH_DESCRIPTOR_UI |
| 54841 | PUBCHEM_CID |
| 7118 | IUPHAR_LIGAND_ID |
| 5354 | INN_ID |
| ASW034S0B8 | UNII |
| 17042 | MMSL |
| 192105 | MMSL |
| 31170 | MMSL |
| 45567 | MMSL |
| d04827 | MMSL |
| A1LX4 | PDB_CHEM_ID |
| 4021364 | VANDF |
| 4024296 | VANDF |
| 009862 | NDDF |
| 009863 | NDDF |
| 407037005 | SNOMEDCT_US |
| 407038000 | SNOMEDCT_US |
| 412577007 | SNOMEDCT_US |
| ASW034S0B8 | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3227 | CAPSULE | 10 mg | ORAL | NDA | 36 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3228 | CAPSULE | 25 mg | ORAL | NDA | 36 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3229 | CAPSULE | 40 mg | ORAL | NDA | 36 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3238 | CAPSULE | 18 mg | ORAL | NDA | 36 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3239 | CAPSULE | 60 mg | ORAL | NDA | 36 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3250 | CAPSULE | 80 mg | ORAL | NDA | 36 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3251 | CAPSULE | 100 mg | ORAL | NDA | 36 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3542 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3543 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3544 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3545 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3546 | CAPSULE | 60 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3547 | CAPSULE | 80 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3548 | CAPSULE | 100 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2260 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2261 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2262 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2263 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2264 | CAPSULE | 60 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2265 | CAPSULE | 80 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2266 | CAPSULE | 100 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6908 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
| STRATTERA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-337 | CAPSULE | 10 mg | ORAL | NDA | 35 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-755 | CAPSULE | 10 mg | ORAL | ANDA | 34 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-756 | CAPSULE | 18 mg | ORAL | ANDA | 34 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-757 | CAPSULE | 25 mg | ORAL | ANDA | 34 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-758 | CAPSULE | 40 mg | ORAL | ANDA | 34 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-759 | CAPSULE | 60 mg | ORAL | ANDA | 34 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-760 | CAPSULE | 80 mg | ORAL | ANDA | 34 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-761 | CAPSULE | 100 mg | ORAL | ANDA | 34 sections |