atomoxetine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives | 256 | 83015-26-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 80 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 27.80 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 8.39 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 94 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.85 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 9.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 5.20 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 26, 2002 | FDA | LILLY |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Suicidal ideation | 216.35 | 19.25 | 130 | 8536 | 60381 | 53280019 |
| Prescribed overdose | 159.45 | 19.25 | 66 | 8600 | 13793 | 53326607 |
| Tic | 112.25 | 19.25 | 29 | 8637 | 1353 | 53339047 |
| Aggression | 106.76 | 19.25 | 59 | 8607 | 23344 | 53317056 |
| Irritability | 106.60 | 19.25 | 65 | 8601 | 30888 | 53309512 |
| Abnormal behaviour | 99.40 | 19.25 | 55 | 8611 | 21811 | 53318589 |
| Agitation | 79.37 | 19.25 | 70 | 8596 | 58556 | 53281844 |
| Tachycardia | 76.51 | 19.25 | 91 | 8575 | 108121 | 53232279 |
| Crying | 74.71 | 19.25 | 46 | 8620 | 22216 | 53318184 |
| Depression | 70.71 | 19.25 | 115 | 8551 | 182937 | 53157463 |
| Myocarditis | 70.13 | 19.25 | 32 | 8634 | 8436 | 53331964 |
| Intentional self-injury | 66.93 | 19.25 | 45 | 8621 | 25239 | 53315161 |
| Suicide attempt | 66.14 | 19.25 | 63 | 8603 | 58105 | 53282295 |
| Attention deficit hyperactivity disorder | 61.55 | 19.25 | 21 | 8645 | 2571 | 53337829 |
| Overdose | 59.31 | 19.25 | 80 | 8586 | 107656 | 53232744 |
| Disturbance in attention | 58.80 | 19.25 | 47 | 8619 | 34336 | 53306064 |
| Intentional overdose | 48.25 | 19.25 | 57 | 8609 | 67148 | 53273252 |
| Somnolence | 47.44 | 19.25 | 92 | 8574 | 167642 | 53172758 |
| Seizure | 45.44 | 19.25 | 78 | 8588 | 129431 | 53210969 |
| Blepharospasm | 45.41 | 19.25 | 17 | 8649 | 2719 | 53337681 |
| Anxiety | 45.17 | 19.25 | 99 | 8567 | 196605 | 53143795 |
| Raynaud's phenomenon | 45.13 | 19.25 | 14 | 8652 | 1268 | 53339132 |
| Psychomotor hyperactivity | 42.07 | 19.25 | 24 | 8642 | 10072 | 53330328 |
| Mania | 41.10 | 19.25 | 25 | 8641 | 11804 | 53328596 |
| Liver injury | 39.46 | 19.25 | 31 | 8635 | 22072 | 53318328 |
| Loss of consciousness | 39.02 | 19.25 | 68 | 8598 | 114144 | 53226256 |
| Trichotillomania | 38.99 | 19.25 | 8 | 8658 | 131 | 53340269 |
| Mood swings | 38.95 | 19.25 | 28 | 8638 | 17458 | 53322942 |
| Impulsive behaviour | 38.75 | 19.25 | 13 | 8653 | 1511 | 53338889 |
| Anger | 37.53 | 19.25 | 24 | 8642 | 12366 | 53328034 |
| Electrocardiogram QT prolonged | 37.47 | 19.25 | 46 | 8620 | 56357 | 53284043 |
| Supine hypertension | 36.87 | 19.25 | 7 | 8659 | 75 | 53340325 |
| Dystonia | 36.44 | 19.25 | 24 | 8642 | 12997 | 53327403 |
| Oppositional defiant disorder | 34.14 | 19.25 | 6 | 8660 | 40 | 53340360 |
| Aspartate aminotransferase increased | 34.01 | 19.25 | 54 | 8612 | 83975 | 53256425 |
| Bipolar I disorder | 33.29 | 19.25 | 12 | 8654 | 1725 | 53338675 |
| Mydriasis | 31.99 | 19.25 | 21 | 8645 | 11305 | 53329095 |
| Educational problem | 31.30 | 19.25 | 8 | 8658 | 357 | 53340043 |
| Obsessive-compulsive disorder | 31.02 | 19.25 | 14 | 8652 | 3596 | 53336804 |
| Heart rate increased | 30.73 | 19.25 | 51 | 8615 | 82264 | 53258136 |
| Renal tubular acidosis | 29.50 | 19.25 | 11 | 8655 | 1740 | 53338660 |
| Thinking abnormal | 28.51 | 19.25 | 19 | 8647 | 10489 | 53329911 |
| Rheumatoid arthritis | 28.37 | 19.25 | 8 | 8658 | 314523 | 53025877 |
| Drug screen positive | 27.01 | 19.25 | 13 | 8653 | 3859 | 53336541 |
| Piloerection | 26.91 | 19.25 | 7 | 8659 | 335 | 53340065 |
| Feeling abnormal | 26.49 | 19.25 | 64 | 8602 | 135237 | 53205163 |
| Congestive hepatopathy | 25.06 | 19.25 | 11 | 8655 | 2645 | 53337755 |
| Alanine aminotransferase increased | 24.25 | 19.25 | 50 | 8616 | 95045 | 53245355 |
| Dysmenorrhoea | 24.23 | 19.25 | 12 | 8654 | 3789 | 53336611 |
| Hypomania | 24.16 | 19.25 | 13 | 8653 | 4869 | 53335531 |
| Social avoidant behaviour | 23.75 | 19.25 | 11 | 8655 | 2997 | 53337403 |
| Mood altered | 23.74 | 19.25 | 19 | 8647 | 13882 | 53326518 |
| Psychotic disorder | 23.22 | 19.25 | 24 | 8642 | 24361 | 53316039 |
| Diarrhoea | 22.71 | 19.25 | 42 | 8624 | 625504 | 52714896 |
| Emotional disorder | 22.66 | 19.25 | 18 | 8648 | 13012 | 53327388 |
| Pneumonia | 22.34 | 19.25 | 20 | 8646 | 407149 | 52933251 |
| Personality change | 21.51 | 19.25 | 13 | 8653 | 6064 | 53334336 |
| Insomnia | 21.47 | 19.25 | 73 | 8593 | 186999 | 53153401 |
| Hepatitis | 21.46 | 19.25 | 27 | 8639 | 33867 | 53306533 |
| Abnormal dreams | 21.40 | 19.25 | 16 | 8650 | 10585 | 53329815 |
| Migraine | 21.35 | 19.25 | 43 | 8623 | 80374 | 53260026 |
| Acute kidney injury | 20.18 | 19.25 | 8 | 8658 | 253860 | 53086540 |
| Lymphocytic hypophysitis | 20.02 | 19.25 | 5 | 8661 | 203 | 53340197 |
| Merycism | 20.02 | 19.25 | 5 | 8661 | 203 | 53340197 |
| Generalised tonic-clonic seizure | 19.97 | 19.25 | 24 | 8642 | 28734 | 53311666 |
| Palpitations | 19.58 | 19.25 | 48 | 8618 | 102300 | 53238100 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Suicidal ideation | 671.28 | 22.62 | 332 | 14358 | 37751 | 32461085 |
| Tic | 581.28 | 22.62 | 144 | 14546 | 1950 | 32496886 |
| Aggression | 550.96 | 22.62 | 294 | 14396 | 39095 | 32459741 |
| Prescribed overdose | 482.57 | 22.62 | 176 | 14514 | 9343 | 32489493 |
| Abnormal behaviour | 348.52 | 22.62 | 190 | 14500 | 26276 | 32472560 |
| Anger | 258.44 | 22.62 | 120 | 14570 | 11784 | 32487052 |
| Irritability | 241.44 | 22.62 | 146 | 14544 | 24508 | 32474328 |
| Crying | 208.78 | 22.62 | 84 | 14606 | 5812 | 32493024 |
| Intentional self-injury | 191.72 | 22.62 | 103 | 14587 | 13797 | 32485039 |
| Psychomotor hyperactivity | 174.30 | 22.62 | 84 | 14606 | 8955 | 32489881 |
| Testicular pain | 170.15 | 22.62 | 60 | 14630 | 2876 | 32495960 |
| Oppositional defiant disorder | 159.99 | 22.62 | 39 | 14651 | 490 | 32498346 |
| Ejaculation disorder | 143.42 | 22.62 | 41 | 14649 | 982 | 32497854 |
| Homicidal ideation | 133.61 | 22.62 | 49 | 14641 | 2631 | 32496205 |
| Agitation | 133.07 | 22.62 | 146 | 14544 | 57090 | 32441746 |
| Suicide attempt | 126.33 | 22.62 | 118 | 14572 | 38126 | 32460710 |
| Mood swings | 125.30 | 22.62 | 65 | 14625 | 8100 | 32490736 |
| Urinary hesitation | 121.16 | 22.62 | 44 | 14646 | 2297 | 32496539 |
| Disturbance in attention | 118.79 | 22.62 | 93 | 14597 | 23660 | 32475176 |
| Impulsive behaviour | 112.75 | 22.62 | 41 | 14649 | 2148 | 32496688 |
| Anxiety | 108.89 | 22.62 | 172 | 14518 | 95833 | 32403003 |
| Heart rate increased | 108.28 | 22.62 | 113 | 14577 | 41715 | 32457121 |
| Depressed mood | 105.49 | 22.62 | 78 | 14612 | 18222 | 32480614 |
| Attention deficit hyperactivity disorder | 104.95 | 22.62 | 39 | 14651 | 2173 | 32496663 |
| Acute kidney injury | 102.66 | 22.62 | 8 | 14682 | 293460 | 32205376 |
| Death | 98.32 | 22.62 | 26 | 14664 | 382491 | 32116345 |
| Pneumonia | 97.47 | 22.62 | 21 | 14669 | 355231 | 32143605 |
| Mood altered | 95.58 | 22.62 | 56 | 14634 | 8848 | 32489988 |
| Decreased eye contact | 92.96 | 22.62 | 25 | 14665 | 474 | 32498362 |
| Bruxism | 92.53 | 22.62 | 33 | 14657 | 1634 | 32497202 |
| Hallucination, auditory | 90.30 | 22.62 | 57 | 14633 | 10293 | 32488543 |
| Depression | 90.11 | 22.62 | 159 | 14531 | 96901 | 32401935 |
| Somnolence | 89.94 | 22.62 | 165 | 14525 | 103632 | 32395204 |
| Insomnia | 86.29 | 22.62 | 159 | 14531 | 100189 | 32398647 |
| Drug screen positive | 80.48 | 22.62 | 39 | 14651 | 4202 | 32494634 |
| Mania | 76.49 | 22.62 | 50 | 14640 | 9582 | 32489254 |
| Palpitations | 75.39 | 22.62 | 87 | 14603 | 35882 | 32462954 |
| Product substitution issue | 72.85 | 22.62 | 50 | 14640 | 10386 | 32488450 |
| Psychotic disorder | 72.08 | 22.62 | 69 | 14621 | 22951 | 32475885 |
| Self-injurious ideation | 70.94 | 22.62 | 27 | 14663 | 1607 | 32497229 |
| Alanine aminotransferase increased | 70.78 | 22.62 | 127 | 14563 | 78352 | 32420484 |
| Mydriasis | 70.39 | 22.62 | 41 | 14649 | 6405 | 32492431 |
| Dystonia | 69.71 | 22.62 | 49 | 14641 | 10574 | 32488262 |
| Educational problem | 66.21 | 22.62 | 19 | 14671 | 461 | 32498375 |
| Feeling abnormal | 65.31 | 22.62 | 106 | 14584 | 60317 | 32438519 |
| Tachycardia | 65.04 | 22.62 | 123 | 14567 | 78965 | 32419871 |
| Aspartate aminotransferase increased | 64.41 | 22.62 | 111 | 14579 | 66318 | 32432518 |
| Seizure | 61.36 | 22.62 | 141 | 14549 | 103713 | 32395123 |
| Anaemia | 59.63 | 22.62 | 14 | 14676 | 223610 | 32275226 |
| Sepsis | 59.40 | 22.62 | 3 | 14687 | 158831 | 32340005 |
| Electrocardiogram QT prolonged | 59.28 | 22.62 | 81 | 14609 | 39560 | 32459276 |
| Suicidal behaviour | 59.20 | 22.62 | 23 | 14667 | 1448 | 32497388 |
| Dysuria | 58.38 | 22.62 | 64 | 14626 | 24946 | 32473890 |
| Dyskinesia | 56.13 | 22.62 | 61 | 14629 | 23542 | 32475294 |
| Diarrhoea | 55.63 | 22.62 | 50 | 14640 | 364752 | 32134084 |
| Choreoathetosis | 55.30 | 22.62 | 20 | 14670 | 1031 | 32497805 |
| Penile discharge | 54.05 | 22.62 | 11 | 14679 | 55 | 32498781 |
| Blood alkaline phosphatase increased | 53.17 | 22.62 | 69 | 14621 | 32063 | 32466773 |
| Retching | 52.12 | 22.62 | 34 | 14656 | 6491 | 32492345 |
| Nervousness | 52.09 | 22.62 | 44 | 14646 | 12435 | 32486401 |
| Emotional disorder | 50.06 | 22.62 | 31 | 14659 | 5410 | 32493426 |
| Trismus | 49.65 | 22.62 | 24 | 14666 | 2571 | 32496265 |
| Affect lability | 46.86 | 22.62 | 26 | 14664 | 3702 | 32495134 |
| Generalised tonic-clonic seizure | 43.35 | 22.62 | 50 | 14640 | 20589 | 32478247 |
| Febrile neutropenia | 42.44 | 22.62 | 3 | 14687 | 119563 | 32379273 |
| Headache | 42.32 | 22.62 | 188 | 14502 | 196009 | 32302827 |
| Gilbert's syndrome | 40.76 | 22.62 | 8 | 14682 | 32 | 32498804 |
| General physical health deterioration | 40.60 | 22.62 | 3 | 14687 | 115256 | 32383580 |
| Screaming | 39.43 | 22.62 | 17 | 14673 | 1397 | 32497439 |
| Social avoidant behaviour | 39.36 | 22.62 | 22 | 14668 | 3177 | 32495659 |
| Growth retardation | 39.16 | 22.62 | 18 | 14672 | 1721 | 32497115 |
| Enuresis | 38.87 | 22.62 | 19 | 14671 | 2085 | 32496751 |
| Coordination abnormal | 37.97 | 22.62 | 30 | 14660 | 7718 | 32491118 |
| Paranoia | 36.92 | 22.62 | 34 | 14656 | 10765 | 32488071 |
| Sexual dysfunction | 36.65 | 22.62 | 27 | 14663 | 6262 | 32492574 |
| Trichotillomania | 36.53 | 22.62 | 8 | 14682 | 60 | 32498776 |
| Blood bilirubin increased | 36.50 | 22.62 | 64 | 14626 | 38720 | 32460116 |
| Tearfulness | 36.37 | 22.62 | 17 | 14673 | 1689 | 32497147 |
| Thrombocytopenia | 36.24 | 22.62 | 11 | 14679 | 148288 | 32350548 |
| Panic attack | 35.29 | 22.62 | 31 | 14659 | 9230 | 32489606 |
| Obsessive-compulsive disorder | 35.28 | 22.62 | 24 | 14666 | 4910 | 32493926 |
| Hepatic enzyme increased | 34.70 | 22.62 | 61 | 14629 | 36976 | 32461860 |
| Thinking abnormal | 34.67 | 22.62 | 25 | 14665 | 5610 | 32493226 |
| Renal failure | 34.66 | 22.62 | 9 | 14681 | 134469 | 32364367 |
| Sleep disorder | 34.56 | 22.62 | 51 | 14639 | 26701 | 32472135 |
| Negativism | 34.03 | 22.62 | 11 | 14679 | 402 | 32498434 |
| Pallor | 33.05 | 22.62 | 46 | 14644 | 22835 | 32476001 |
| Loss of consciousness | 33.02 | 22.62 | 97 | 14593 | 82610 | 32416226 |
| Physical assault | 32.97 | 22.62 | 14 | 14676 | 1108 | 32497728 |
| Apathy | 32.91 | 22.62 | 26 | 14664 | 6689 | 32492147 |
| Personality change | 32.40 | 22.62 | 23 | 14667 | 5036 | 32493800 |
| Fight in school | 31.17 | 22.62 | 5 | 14685 | 3 | 32498833 |
| Cardiac failure | 30.59 | 22.62 | 3 | 14687 | 91670 | 32407166 |
| Decreased appetite | 30.15 | 22.62 | 148 | 14542 | 160665 | 32338171 |
| Respiratory failure | 29.96 | 22.62 | 6 | 14684 | 107176 | 32391660 |
| Abdominal pain upper | 29.82 | 22.62 | 82 | 14608 | 67256 | 32431580 |
| Tourette's disorder | 29.16 | 22.62 | 7 | 14683 | 82 | 32498754 |
| Hyperhidrosis | 28.91 | 22.62 | 84 | 14606 | 71084 | 32427752 |
| Scrotal pain | 28.89 | 22.62 | 12 | 14678 | 899 | 32497937 |
| Raynaud's phenomenon | 28.50 | 22.62 | 9 | 14681 | 305 | 32498531 |
| Repetitive speech | 28.01 | 22.62 | 7 | 14683 | 98 | 32498738 |
| Urinary retention | 27.43 | 22.62 | 54 | 14636 | 35643 | 32463193 |
| Erectile dysfunction | 27.34 | 22.62 | 39 | 14651 | 19800 | 32479036 |
| Syncope | 27.16 | 22.62 | 96 | 14594 | 90028 | 32408808 |
| Pyromania | 27.06 | 22.62 | 6 | 14684 | 48 | 32498788 |
| Pyrexia | 26.25 | 22.62 | 67 | 14623 | 319901 | 32178935 |
| Hyperkinesia | 26.20 | 22.62 | 15 | 14675 | 2267 | 32496569 |
| Hostility | 25.84 | 22.62 | 11 | 14679 | 876 | 32497960 |
| Asthenia | 25.63 | 22.62 | 42 | 14648 | 235902 | 32262934 |
| Abdominal discomfort | 25.22 | 22.62 | 66 | 14624 | 52558 | 32446278 |
| Sedation | 24.91 | 22.62 | 36 | 14654 | 18490 | 32480346 |
| Amphetamines positive | 24.62 | 22.62 | 7 | 14683 | 164 | 32498672 |
| Speech disorder | 24.28 | 22.62 | 43 | 14647 | 26210 | 32472626 |
| Vomiting | 23.93 | 22.62 | 185 | 14505 | 235372 | 32263464 |
| Dyspnoea | 23.81 | 22.62 | 84 | 14606 | 361961 | 32136875 |
| Chest pain | 23.78 | 22.62 | 115 | 14575 | 124022 | 32374814 |
| Oedema peripheral | 23.61 | 22.62 | 11 | 14679 | 114080 | 32384756 |
| Hyponatraemia | 23.44 | 22.62 | 3 | 14687 | 74510 | 32424326 |
| Dysphoria | 23.39 | 22.62 | 14 | 14676 | 2297 | 32496539 |
| Semen analysis abnormal | 23.26 | 22.62 | 5 | 14685 | 34 | 32498802 |
| Myocardial infarction | 23.24 | 22.62 | 14 | 14676 | 125662 | 32373174 |
| Poor quality sleep | 23.01 | 22.62 | 23 | 14667 | 8051 | 32490785 |
| Appendicitis | 22.83 | 22.62 | 24 | 14666 | 8913 | 32489923 |
| Pain | 22.67 | 22.62 | 31 | 14659 | 187525 | 32311311 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BA09 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics |
| FDA MoA | N0000000102 | Norepinephrine Uptake Inhibitors |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| FDA EPC | N0000175695 | Norepinephrine Reuptake Inhibitor |
| CHEBI has role | CHEBI:35469 | thymoanaleptics |
| CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Attention deficit hyperactivity disorder | indication | 406506008 | |
| Delay when starting to pass urine | contraindication | 5972002 | |
| Priapism | contraindication | 6273006 | DOID:9286 |
| Suicidal thoughts | contraindication | 6471006 | |
| Sinus tachycardia | contraindication | 11092001 | |
| Bipolar disorder | contraindication | 13746004 | DOID:3312 |
| Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Feeling agitated | contraindication | 24199005 | |
| Orthostatic hypotension | contraindication | 28651003 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Feeling irritable | contraindication | 55929007 | |
| Aggressive behavior | contraindication | 61372001 | |
| Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
| Psychotic disorder | contraindication | 69322001 | |
| Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
| Structural disorder of heart | contraindication | 128599005 | |
| Seizure disorder | contraindication | 128613002 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Mania | contraindication | 231494001 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Raynaud's phenomenon | contraindication | 266261006 | |
| Retention of urine | contraindication | 267064002 | |
| Pheochromocytoma | contraindication | 302835009 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial infarction in recovery phase | contraindication | 418044006 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.32 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 8.69 | CHEMBL | CHEMBL | |||
| Sodium-dependent serotonin transporter | Transporter | Kd | 8.05 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Kd | 5.97 | CHEMBL | |||||
| Cytochrome P450 2D6 | Enzyme | Ki | 4.77 | WOMBAT-PK | |||||
| G protein-activated inward rectifier potassium channel 2 | Ion channel | IC50 | 4.28 | WOMBAT-PK | |||||
| Kir3.1/Kir3.2 | Ion channel | IC50 | 4.48 | WOMBAT-PK | |||||
| Kir3.1/Kir3.4 | Ion channel | IC50 | 4.85 | WOMBAT-PK | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.68 | CHEMBL | |||||
| Krueppel-like factor 10 | Nuclear other | IC50 | 4 | CHEMBL | |||||
| Sodium-dependent serotonin transporter | Transporter | Ki | 7.37 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.85 | CHEMBL | |||||
| Transporter | Transporter | Ki | 9.15 | CHEMBL | |||||
| Transporter | Transporter | Ki | 8.40 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02574 | KEGG_DRUG |
| 82248-59-7 | SECONDARY_CAS_RN |
| 353103 | RXNORM |
| C0076823 | UMLSCUI |
| CHEBI:331697 | CHEBI |
| CHEMBL641 | ChEMBL_ID |
| CHEMBL1702 | ChEMBL_ID |
| DB00289 | DRUGBANK_ID |
| D000069445 | MESH_DESCRIPTOR_UI |
| 5354 | INN_ID |
| 54841 | PUBCHEM_CID |
| 7118 | IUPHAR_LIGAND_ID |
| ASW034S0B8 | UNII |
| 17042 | MMSL |
| 192105 | MMSL |
| 45567 | MMSL |
| d04827 | MMSL |
| 009862 | NDDF |
| 009863 | NDDF |
| 407037005 | SNOMEDCT_US |
| 407038000 | SNOMEDCT_US |
| 412577007 | SNOMEDCT_US |
| 4021364 | VANDF |
| 4024296 | VANDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3227 | CAPSULE | 10 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3228 | CAPSULE | 25 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3229 | CAPSULE | 40 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3238 | CAPSULE | 18 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3239 | CAPSULE | 60 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3250 | CAPSULE | 80 mg | ORAL | NDA | 38 sections |
| Strattera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0002-3251 | CAPSULE | 100 mg | ORAL | NDA | 38 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3542 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3543 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3544 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3545 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3546 | CAPSULE | 60 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3547 | CAPSULE | 80 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3548 | CAPSULE | 100 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2260 | CAPSULE | 10 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2261 | CAPSULE | 18 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2262 | CAPSULE | 25 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2263 | CAPSULE | 40 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2264 | CAPSULE | 60 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2265 | CAPSULE | 80 mg | ORAL | ANDA | 32 sections |
| Atomoxetine hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2266 | CAPSULE | 100 mg | ORAL | ANDA | 32 sections |
| Atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6908 | CAPSULE | 40 mg | ORAL | ANDA | 31 sections |
| STRATTERA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-337 | CAPSULE | 10 mg | ORAL | NDA | 35 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-755 | CAPSULE | 10 mg | ORAL | ANDA | 33 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-756 | CAPSULE | 18 mg | ORAL | ANDA | 33 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-757 | CAPSULE | 25 mg | ORAL | ANDA | 33 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-758 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-759 | CAPSULE | 60 mg | ORAL | ANDA | 33 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-760 | CAPSULE | 80 mg | ORAL | ANDA | 33 sections |
| atomoxetine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-761 | CAPSULE | 100 mg | ORAL | ANDA | 33 sections |