atomoxetine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 256 83015-26-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • LY139603
  • strattera
  • atomoxetine
  • tomoxetine
  • (-)-Tomoxetine
  • atomoxetine hydrochloride
  • tomoxetine hydrochloride
  • atomoxetine HCl
  • tomoxetine HCl
A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
  • Molecular weight: 255.36
  • Formula: C17H21NO
  • CLOGP: 3.94
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -4.82
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
80 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 8.39 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 94 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.85 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 2002 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicidal ideation 225.16 19.40 134 8963 55251 50540776
Prescribed overdose 149.68 19.40 66 9031 14534 50581493
Tic 112.99 19.40 29 9068 1188 50594839
Irritability 108.17 19.40 66 9031 28360 50567667
Blepharospasm 108.08 19.40 34 9063 2914 50593113
Aggression 106.84 19.40 59 9038 21057 50574970
Abnormal behaviour 102.41 19.40 56 9041 19602 50576425
Crying 74.08 19.40 46 9051 20370 50575657
Agitation 72.98 19.40 67 9030 53317 50542710
Myocarditis 72.10 19.40 33 9064 7914 50588113
Tachycardia 71.79 19.40 89 9008 99674 50496353
Suicide attempt 66.99 19.40 63 9034 51669 50544358
Depression 66.64 19.40 112 8985 165311 50430716
Disturbance in attention 65.12 19.40 50 9047 31136 50564891
Intentional self-injury 64.08 19.40 44 9053 23068 50572959
Taste disorder 61.49 19.40 30 9067 8294 50587733
Attention deficit hyperactivity disorder 60.80 19.40 21 9076 2408 50593619
Overdose 56.30 19.40 79 9018 99648 50496379
Somnolence 50.88 19.40 96 9001 154889 50441138
Impulsive behaviour 50.06 19.40 16 9081 1442 50594585
Epilepsy 48.16 19.40 36 9061 21531 50574496
Mood swings 45.70 19.40 31 9066 15923 50580104
Raynaud's phenomenon 44.93 19.40 14 9083 1162 50594865
Anxiety 44.08 19.40 98 8999 177508 50418519
Intentional overdose 43.69 19.40 55 9042 62449 50533578
Psychomotor hyperactivity 41.64 19.40 24 9073 9277 50586750
Seizure 41.15 19.40 75 9022 117799 50478228
Loss of consciousness 41.08 19.40 70 9027 104283 50491744
Mania 40.61 19.40 25 9072 10891 50585136
Trichotillomania 38.96 19.40 8 9089 118 50595909
Liver injury 37.56 19.40 33 9064 24773 50571254
Supine hypertension 37.47 19.40 7 9090 61 50595966
Anger 37.26 19.40 24 9073 11309 50584718
Electrocardiogram QT prolonged 35.22 19.40 45 9052 51841 50544186
Psychotic disorder 35.00 19.40 30 9067 21782 50574245
Memory impairment 34.94 19.40 56 9041 79304 50516723
Dystonia 33.74 19.40 23 9074 11903 50584124
Bipolar I disorder 33.68 19.40 12 9085 1506 50594521
Oppositional defiant disorder 33.53 19.40 6 9091 40 50595987
Aspartate aminotransferase increased 32.92 19.40 54 9043 77944 50518083
Obsessive-compulsive disorder 30.70 19.40 14 9083 3326 50592701
Paraesthesia 30.53 19.40 67 9030 120176 50475851
Drug screen positive 30.45 19.40 14 9083 3388 50592639
Educational problem 30.20 19.40 8 9089 371 50595656
Renal tubular acidosis 29.83 19.40 11 9086 1523 50594504
Product tampering 29.60 19.40 7 9090 203 50595824
Mydriasis 28.90 19.40 20 9077 10607 50585420
Feeling abnormal 28.60 19.40 67 9030 125425 50470602
Completed suicide 28.53 19.40 69 9028 131820 50464207
Gastrooesophageal reflux disease 28.40 19.40 50 9047 76378 50519649
Heart rate increased 28.01 19.40 50 9047 77200 50518827
Pulse abnormal 27.86 19.40 11 9086 1834 50594193
Hypomania 26.72 19.40 14 9083 4491 50591536
Piloerection 26.54 19.40 7 9090 319 50595708
Thinking abnormal 26.00 19.40 18 9079 9549 50586478
Diarrhoea 25.22 19.40 42 9055 588434 50007593
Congestive hepatopathy 24.66 19.40 11 9086 2483 50593544
Dysmenorrhoea 24.65 19.40 12 9085 3298 50592729
Mood altered 23.46 19.40 19 9078 12754 50583273
Social avoidant behaviour 23.45 19.40 11 9086 2786 50593241
Alanine aminotransferase increased 23.28 19.40 50 9047 88309 50507718
Emotional disorder 22.58 19.40 18 9079 11818 50584209
Pneumonia 22.46 19.40 21 9076 378380 50217647
Palpitations 22.12 19.40 51 9046 94455 50501572
Hypoaesthesia 21.78 19.40 61 9036 127196 50468831
Hyperhidrosis 21.75 19.40 49 9048 89377 50506650
Bipolar disorder 21.45 19.40 14 9083 6743 50589284
Personality change 21.18 19.40 13 9084 5632 50590395
Hepatitis 20.89 19.40 27 9070 31426 50564601
Joint swelling 20.86 19.40 9 9088 245277 50350750
Peripheral swelling 20.16 19.40 6 9091 205930 50390097
Insomnia 20.04 19.40 73 9024 174792 50421235
Acute kidney injury 19.98 19.40 8 9089 228050 50367977
Merycism 19.94 19.40 5 9092 186 50595841
Generalised tonic-clonic seizure 19.73 19.40 24 9073 26286 50569741
Abnormal dreams 19.48 19.40 15 9082 9362 50586665

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicidal ideation 665.28 23.15 328 14058 34388 29525753
Tic 559.19 23.15 138 14248 1697 29558444
Aggression 527.86 23.15 283 14103 35258 29524883
Prescribed overdose 485.69 23.15 176 14210 8507 29551634
Abnormal behaviour 342.50 23.15 184 14202 22943 29537198
Anger 260.19 23.15 120 14266 10770 29549371
Irritability 238.12 23.15 143 14243 22009 29538132
Crying 203.73 23.15 82 14304 5269 29554872
Intentional self-injury 195.17 23.15 103 14283 12358 29547783
Testicular pain 175.05 23.15 60 14326 2449 29557692
Psychomotor hyperactivity 166.96 23.15 81 14305 8132 29552009
Oppositional defiant disorder 146.99 23.15 37 14349 494 29559647
Ejaculation disorder 142.67 23.15 41 14345 927 29559214
Agitation 130.33 23.15 142 14244 51162 29508979
Homicidal ideation 129.27 23.15 48 14338 2476 29557665
Mood swings 128.06 23.15 65 14321 7186 29552955
Urinary hesitation 127.87 23.15 46 14340 2167 29557974
Suicide attempt 118.78 23.15 112 14274 33998 29526143
Disturbance in attention 112.52 23.15 89 14297 21335 29538806
Anxiety 111.72 23.15 170 14216 85195 29474946
Impulsive behaviour 110.81 23.15 40 14346 1903 29558238
Heart rate increased 106.29 23.15 112 14274 38826 29521315
Depressed mood 105.52 23.15 77 14309 16371 29543770
Acute kidney injury 99.30 23.15 8 14378 265259 29294882
Pneumonia 97.43 23.15 19 14367 320153 29239988
Death 96.64 23.15 24 14362 342060 29218081
Mood altered 93.95 23.15 55 14331 8056 29552085
Depression 92.75 23.15 156 14230 84991 29475150
Attention deficit hyperactivity disorder 91.41 23.15 36 14350 2181 29557960
Insomnia 90.61 23.15 158 14228 88603 29471538
Hallucination, auditory 90.41 23.15 57 14329 9536 29550605
Somnolence 87.91 23.15 161 14225 93794 29466347
Decreased eye contact 87.19 23.15 24 14362 461 29559680
Bruxism 84.28 23.15 31 14355 1556 29558585
Drug screen positive 81.81 23.15 39 14347 3762 29556379
Palpitations 77.12 23.15 87 14299 32517 29527624
Product substitution issue 75.36 23.15 50 14336 9122 29551019
Psychotic disorder 74.99 23.15 69 14317 20285 29539856
Mania 73.06 23.15 48 14338 8615 29551526
Alanine aminotransferase increased 70.68 23.15 125 14261 70819 29489322
Self-injurious ideation 70.37 23.15 27 14359 1524 29558617
Mydriasis 69.78 23.15 41 14345 6044 29554097
Feeling abnormal 69.11 23.15 107 14279 54338 29505803
Tachycardia 67.56 23.15 124 14262 72286 29487855
Aspartate aminotransferase increased 64.40 23.15 109 14277 59616 29500525
Seizure 63.58 23.15 140 14246 92983 29467158
Dystonia 63.32 23.15 46 14340 9703 29550438
Educational problem 63.08 23.15 19 14367 508 29559633
Suicidal behaviour 62.78 23.15 24 14362 1341 29558800
Dysuria 60.21 23.15 64 14322 22376 29537765
Penile discharge 59.68 23.15 12 14374 51 29560090
Sepsis 57.14 23.15 3 14383 142679 29417462
Anaemia 56.79 23.15 14 14372 200937 29359204
Diarrhoea 55.95 23.15 48 14338 332650 29227491
Electrocardiogram QT prolonged 55.93 23.15 78 14308 36059 29524082
Dyskinesia 55.21 23.15 58 14328 20003 29540138
Choreoathetosis 54.44 23.15 20 14366 1000 29559141
Blood alkaline phosphatase increased 54.28 23.15 68 14318 28338 29531803
Nervousness 53.05 23.15 44 14342 11262 29548879
Retching 52.57 23.15 34 14352 5939 29554202
Emotional disorder 50.76 23.15 31 14355 4900 29555241
Trismus 46.99 23.15 23 14363 2350 29557791
Headache 46.24 23.15 187 14199 173820 29386321
Generalised tonic-clonic seizure 43.42 23.15 50 14336 19089 29541052
Affect lability 41.86 23.15 24 14362 3378 29556763
Gilbert's syndrome 40.80 23.15 8 14378 29 29560112
Coordination abnormal 40.46 23.15 31 14355 7083 29553058
Febrile neutropenia 40.23 23.15 4 14382 112236 29447905
Screaming 39.98 23.15 17 14369 1253 29558888
Social avoidant behaviour 39.56 23.15 22 14364 2920 29557221
Growth retardation 38.94 23.15 18 14368 1618 29558523
Panic attack 38.22 23.15 32 14354 8294 29551847
Sexual dysfunction 36.77 23.15 27 14359 5787 29554354
Blood bilirubin increased 36.68 23.15 62 14324 33831 29526310
General physical health deterioration 36.00 23.15 4 14382 102853 29457288
Tearfulness 35.85 23.15 17 14369 1619 29558522
Paranoia 35.42 23.15 33 14353 9844 29550297
Trichotillomania 35.38 23.15 8 14378 65 29560076
Loss of consciousness 35.24 23.15 97 14289 73959 29486182
Thrombocytopenia 35.05 23.15 11 14375 134812 29425329
Thinking abnormal 34.66 23.15 25 14361 5211 29554930
Hepatic enzyme increased 34.18 23.15 60 14326 33739 29526402
Personality change 32.67 23.15 23 14363 4615 29555526
Physical assault 32.44 23.15 14 14372 1070 29559071
Renal failure 32.05 23.15 9 14377 118590 29441551
Enuresis 31.96 23.15 17 14369 2067 29558074
Pallor 31.94 23.15 45 14341 20979 29539162
Abdominal pain upper 31.13 23.15 82 14304 60911 29499230
Apathy 31.01 23.15 25 14361 6146 29553995
Sleep disorder 31.00 23.15 48 14338 24338 29535803
Fight in school 30.80 23.15 5 14381 3 29560138
Obsessive-compulsive disorder 30.64 23.15 22 14364 4554 29555587
Negativism 30.23 23.15 10 14376 365 29559776
Hyperkinesia 30.18 23.15 15 14371 1584 29558557
Scrotal pain 29.60 23.15 12 14374 784 29559357
Erectile dysfunction 29.54 23.15 40 14346 17969 29542172
Respiratory failure 28.93 23.15 6 14380 97125 29463016
Repetitive speech 28.80 23.15 7 14379 80 29560061
Cardiac failure 27.95 23.15 3 14383 79284 29480857
Syncope 27.86 23.15 95 14291 81276 29478865
Pyrexia 27.66 23.15 62 14324 287560 29272581
Hyperhidrosis 27.25 23.15 81 14305 64459 29495682
Decreased appetite 27.21 23.15 141 14245 145201 29414940
Urinary retention 26.45 23.15 52 14334 31846 29528295
Pyromania 26.29 23.15 6 14380 51 29560090
Abdominal discomfort 26.08 23.15 66 14320 47837 29512304
Hostility 25.93 23.15 11 14375 806 29559335
Speech disorder 25.41 23.15 43 14343 23473 29536668
Dyspnoea 24.93 23.15 79 14307 326653 29233488
Chest pain 24.79 23.15 114 14272 111859 29448282
Amphetamines positive 24.71 23.15 7 14379 150 29559991
Raynaud's phenomenon 24.50 23.15 8 14378 280 29559861
Asthenia 24.48 23.15 42 14344 215208 29344933
Tourette's disorder 24.42 23.15 6 14380 72 29560069
Dysphoria 23.73 23.15 14 14372 2078 29558063
Vomiting 23.50 23.15 180 14206 212080 29348061
Sedation 23.17 23.15 35 14351 17370 29542771

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicidal ideation 705.04 18.15 362 19268 66180 64412922
Tic 684.45 18.15 159 19471 2460 64476642
Prescribed overdose 598.18 18.15 227 19403 20104 64458998
Aggression 561.29 18.15 276 19354 45956 64433146
Abnormal behaviour 402.72 18.15 199 19431 33423 64445679
Irritability 318.18 18.15 175 19455 36571 64442531
Anger 297.70 18.15 128 19502 15613 64463489
Psychomotor hyperactivity 242.38 18.15 108 19522 14343 64464759
Crying 211.38 18.15 109 19521 19981 64459121
Intentional self-injury 202.15 18.15 120 19510 28924 64450178
Oppositional defiant disorder 178.60 18.15 39 19591 447 64478655
Agitation 172.73 18.15 171 19459 88196 64390906
Disturbance in attention 164.20 18.15 120 19510 40954 64438148
Mood swings 158.87 18.15 86 19544 17382 64461720
Ejaculation disorder 149.55 18.15 34 19596 474 64478628
Suicide attempt 145.43 18.15 141 19489 70866 64408236
Homicidal ideation 143.18 18.15 49 19581 3208 64475894
Impulsive behaviour 132.61 18.15 44 19586 2619 64476483
Anxiety 131.17 18.15 227 19403 202422 64276680
Depression 130.15 18.15 214 19416 183077 64296025
Testicular pain 128.80 18.15 39 19591 1721 64477381
Mania 115.14 18.15 68 19562 16218 64462884
Attention deficit hyperactivity disorder 111.42 18.15 39 19591 2731 64476371
Somnolence 111.27 18.15 212 19418 203433 64275669
Urinary hesitation 109.66 18.15 41 19589 3469 64475633
Heart rate increased 108.96 18.15 142 19488 98533 64380569
Educational problem 108.01 18.15 25 19605 379 64478723
Tachycardia 107.96 18.15 176 19454 149403 64329699
Seizure 96.42 18.15 178 19452 166714 64312388
Acute kidney injury 95.93 18.15 12 19618 449228 64029874
Dystonia 93.74 18.15 63 19567 18802 64460300
Hallucination, auditory 92.49 18.15 60 19570 16879 64462223
Decreased eye contact 92.16 18.15 25 19605 740 64478362
Aspartate aminotransferase increased 90.56 18.15 144 19486 119644 64359458
Product substitution issue 89.59 18.15 60 19570 17801 64461301
Blepharospasm 89.56 18.15 35 19595 3340 64475762
Insomnia 87.83 18.15 189 19441 197647 64281455
Alanine aminotransferase increased 84.99 18.15 152 19478 138879 64340223
Pneumonia 83.63 18.15 33 19597 559543 63919559
Psychotic disorder 80.96 18.15 74 19556 34504 64444598
Trichotillomania 80.51 18.15 17 19613 164 64478938
Depressed mood 79.36 18.15 79 19551 40933 64438169
Mood altered 78.52 18.15 53 19577 15926 64463176
Feeling abnormal 75.25 18.15 141 19489 133461 64345641
Bruxism 73.54 18.15 31 19599 3593 64475509
Mydriasis 73.36 18.15 50 19580 15262 64463840
Dyskinesia 70.96 18.15 73 19557 39315 64439787
Electrocardiogram QT prolonged 69.16 18.15 102 19528 79346 64399756
Self-injurious ideation 67.06 18.15 28 19602 3169 64475933
Obsessive-compulsive disorder 65.08 18.15 31 19599 4787 64474315
Drug screen positive 62.88 18.15 32 19598 5697 64473405
Diarrhoea 62.66 18.15 77 19553 722627 63756475
Death 62.02 18.15 35 19595 482670 63996432
Generalised tonic-clonic seizure 61.43 18.15 68 19562 39789 64439313
Loss of consciousness 59.31 18.15 136 19494 148229 64330873
Emotional disorder 57.64 18.15 40 19590 12567 64466535
Retching 57.39 18.15 43 19587 15213 64463889
Palpitations 57.23 18.15 109 19521 104379 64374723
Anaemia 57.04 18.15 22 19608 378658 64100444
Choreoathetosis 56.77 18.15 20 19610 1427 64477675
Suicidal behaviour 56.27 18.15 24 19606 2863 64476239
Social avoidant behaviour 54.56 18.15 27 19603 4530 64474572
Nervousness 51.83 18.15 54 19576 29502 64449600
Growth retardation 51.57 18.15 19 19611 1542 64477560
Blood alkaline phosphatase increased 51.50 18.15 74 19556 56205 64422897
Penile discharge 50.47 18.15 9 19621 31 64479071
Sepsis 49.46 18.15 6 19624 230335 64248767
Bipolar I disorder 49.24 18.15 19 19611 1752 64477350
Personality change 48.29 18.15 31 19599 8562 64470540
Affect lability 47.01 18.15 31 19599 8959 64470143
Hyperhidrosis 45.02 18.15 110 19520 124810 64354292
Thinking abnormal 44.42 18.15 33 19597 11523 64467579
Paranoia 44.25 18.15 38 19592 16314 64462788
Peripheral swelling 43.57 18.15 6 19624 209147 64269955
Nightmare 43.51 18.15 42 19588 20951 64458151
Coordination abnormal 43.01 18.15 36 19594 14928 64464174
Febrile neutropenia 40.00 18.15 5 19625 187652 64291450
Intentional overdose 39.91 18.15 86 19544 89858 64389244
Trismus 38.71 18.15 22 19608 4879 64474223
Taste disorder 38.66 18.15 28 19602 9405 64469697
Gilbert's syndrome 38.43 18.15 7 19623 28 64479074
Epilepsy 38.12 18.15 49 19581 33482 64445620
General physical health deterioration 37.88 18.15 8 19622 204417 64274685
Scrotal pain 37.46 18.15 11 19619 436 64478666
Physical assault 37.41 18.15 15 19615 1531 64477571
Thrombocytopenia 37.14 18.15 11 19619 223790 64255312
Dysuria 36.58 18.15 54 19576 42003 64437099
Overdose 36.34 18.15 119 19511 159447 64319655
Arthralgia 35.27 18.15 50 19580 442210 64036892
Speech disorder 34.87 18.15 57 19573 48384 64430718
Enuresis 34.80 18.15 17 19613 2773 64476329
Joint swelling 33.25 18.15 12 19618 215370 64263732
Hyperkinesia 33.22 18.15 16 19614 2530 64476572
Pancytopenia 32.63 18.15 3 19627 143306 64335796
Decreased appetite 32.41 18.15 170 19460 281119 64197983
Raynaud's phenomenon 32.22 18.15 12 19618 1004 64478098
Bipolar disorder 32.20 18.15 22 19608 6739 64472363
Tourette's disorder 32.15 18.15 7 19623 79 64479023
School refusal 31.85 18.15 6 19624 30 64479072
Blood bilirubin increased 31.44 18.15 60 19570 57493 64421609
Rheumatoid arthritis 31.33 18.15 6 19624 164288 64314814
Sleep disorder 31.09 18.15 61 19569 59648 64419454
Panic attack 30.99 18.15 35 19595 20918 64458184
Infection 30.83 18.15 9 19621 184871 64294231
Petit mal epilepsy 30.39 18.15 19 19611 5013 64474089
Dyspnoea 29.43 18.15 116 19514 718558 63760544
Tearfulness 29.12 18.15 18 19612 4655 64474447
Pain in extremity 28.65 18.15 30 19600 303055 64176047
Renal failure 28.25 18.15 10 19620 181678 64297424
Infusion related reaction 27.43 18.15 8 19622 164459 64314643
Feeling jittery 27.33 18.15 24 19606 10611 64468491
Hyponatraemia 27.08 18.15 6 19624 148333 64330769
Abdominal pain upper 26.87 18.15 115 19515 174915 64304187
Headache 26.75 18.15 262 19368 529205 63949897
Pyromania 26.71 18.15 5 19625 24 64479078
Viral infection 26.65 18.15 43 19587 36097 64443005
Pyrexia 26.28 18.15 85 19545 558559 63920543
Hostility 26.19 18.15 13 19617 2194 64476908
Sedation 26.15 18.15 46 19584 41416 64437686
Myocarditis 26.12 18.15 29 19601 17014 64462088
Completed suicide 26.09 18.15 136 19494 224278 64254824
Chest pain 26.06 18.15 141 19489 235839 64243263
Hypomania 25.98 18.15 18 19612 5636 64473466
Erectile dysfunction 25.67 18.15 25 19605 12602 64466500
Screaming 25.63 18.15 15 19615 3514 64475588
Product tampering 25.58 18.15 7 19623 214 64478888
Neuropathy peripheral 25.36 18.15 3 19627 117522 64361580
Urinary retention 25.29 18.15 50 19580 49151 64429951
Staring 25.11 18.15 13 19617 2397 64476705
Pain 24.81 18.15 86 19544 553425 63925677
Cardiac failure congestive 24.41 18.15 5 19625 130575 64348527
Fall 24.38 18.15 57 19573 416769 64062333
Apathy 24.27 18.15 23 19607 11209 64467893
Negativism 24.18 18.15 9 19621 751 64478351
Restlessness 23.63 18.15 43 19587 39742 64439360
Renal impairment 23.58 18.15 6 19624 135011 64344091
Euphoric mood 23.51 18.15 18 19612 6573 64472529
Vomiting 23.26 18.15 263 19367 550854 63928248
Hypotension 23.17 18.15 51 19579 380923 64098179
Infectious mononucleosis 22.94 18.15 11 19619 1722 64477380
Drooling 22.28 18.15 16 19614 5303 64473799
Supine hypertension 22.19 18.15 7 19623 354 64478748
Dysphemia 21.97 18.15 13 19617 3106 64475996
Cyanosis 21.54 18.15 30 19600 22125 64456977
Gastrointestinal haemorrhage 21.05 18.15 7 19623 132305 64346797
Treatment noncompliance 20.93 18.15 43 19587 43439 64435663
Drug hypersensitivity 20.86 18.15 25 19605 237790 64241312
Rash 20.70 18.15 71 19559 458478 64020624
Pallor 20.65 18.15 40 19590 38741 64440361
Contraindicated product administered 20.42 18.15 4 19626 107825 64371277
Dysphoria 20.24 18.15 14 19616 4374 64474728
Prostatic pain 20.21 18.15 4 19626 27 64479075
Medication error 20.15 18.15 46 19584 49920 64429182
Syncope 20.04 18.15 98 19532 157537 64321565
Hallucination 20.01 18.15 58 19572 72730 64406372
Wolff-Parkinson-White syndrome 19.96 18.15 6 19624 258 64478844
Chromaturia 19.61 18.15 29 19601 22582 64456520
Streptococcal infection 19.46 18.15 17 19613 7462 64471640
Drug abuse 19.38 18.15 8 19622 132366 64346736
Sinus tachycardia 19.38 18.15 35 19595 32153 64446949
Penile pain 19.31 18.15 8 19622 887 64478215
Fight in school 19.22 18.15 3 19627 3 64479099
Male genital atrophy 19.22 18.15 3 19627 3 64479099
Peripheral coldness 18.92 18.15 22 19608 13562 64465540
Stomatitis 18.89 18.15 5 19625 109600 64369502
Haemoglobin decreased 18.76 18.15 19 19611 195044 64284058
Gastric hypomotility 18.73 18.15 5 19625 139 64478963
Blood creatinine increased 18.63 18.15 9 19621 135773 64343329
Distractibility 18.21 18.15 7 19623 639 64478463
Pulmonary embolism 18.19 18.15 11 19619 146345 64332757

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BA09 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Centrally acting sympathomimetics
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
FDA EPC N0000175695 Norepinephrine Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Attention deficit hyperactivity disorder indication 406506008
Delay when starting to pass urine contraindication 5972002
Priapism contraindication 6273006 DOID:9286
Suicidal thoughts contraindication 6471006
Sinus tachycardia contraindication 11092001
Bipolar disorder contraindication 13746004 DOID:3312
Hyperbilirubinemia contraindication 14783006 DOID:2741
Myocardial infarction contraindication 22298006 DOID:5844
Feeling agitated contraindication 24199005
Orthostatic hypotension contraindication 28651003
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Feeling irritable contraindication 55929007
Aggressive behavior contraindication 61372001
Cerebrovascular disease contraindication 62914000 DOID:6713
Psychotic disorder contraindication 69322001
Cardiomyopathy contraindication 85898001 DOID:0050700
Structural disorder of heart contraindication 128599005
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Disease of liver contraindication 235856003 DOID:409
Raynaud's phenomenon contraindication 266261006
Retention of urine contraindication 267064002
Pheochromocytoma contraindication 302835009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Myocardial infarction in recovery phase contraindication 418044006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 8.69 CHEMBL CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 8.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Kd 5.97 CHEMBL
Cytochrome P450 2D6 Enzyme Ki 4.77 WOMBAT-PK
G protein-activated inward rectifier potassium channel 2 Ion channel IC50 4.28 WOMBAT-PK
Kir3.1/Kir3.2 Ion channel IC50 4.48 WOMBAT-PK
Kir3.1/Kir3.4 Ion channel IC50 4.85 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.68 CHEMBL
Krueppel-like factor 10 Nuclear other IC50 4 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.37 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.85 CHEMBL
Transporter Transporter Ki 9.15 CHEMBL
Transporter Transporter Ki 8.40 CHEMBL

External reference:

IDSource
D02574 KEGG_DRUG
82248-59-7 SECONDARY_CAS_RN
353103 RXNORM
C0076823 UMLSCUI
CHEBI:331697 CHEBI
CHEMBL641 ChEMBL_ID
CHEMBL1702 ChEMBL_ID
DB00289 DRUGBANK_ID
D000069445 MESH_DESCRIPTOR_UI
54841 PUBCHEM_CID
7118 IUPHAR_LIGAND_ID
5354 INN_ID
ASW034S0B8 UNII
17042 MMSL
192105 MMSL
45567 MMSL
d04827 MMSL
009862 NDDF
009863 NDDF
4021364 VANDF
4024296 VANDF
407037005 SNOMEDCT_US
407038000 SNOMEDCT_US
412577007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3227 CAPSULE 10 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3228 CAPSULE 25 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3229 CAPSULE 40 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3238 CAPSULE 18 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3239 CAPSULE 60 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3250 CAPSULE 80 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3251 CAPSULE 100 mg ORAL NDA 38 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3542 CAPSULE 10 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3543 CAPSULE 18 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3544 CAPSULE 25 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3545 CAPSULE 40 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3546 CAPSULE 60 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3547 CAPSULE 80 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3548 CAPSULE 100 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2260 CAPSULE 10 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2261 CAPSULE 18 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2262 CAPSULE 25 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2263 CAPSULE 40 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2264 CAPSULE 60 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2265 CAPSULE 80 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2266 CAPSULE 100 mg ORAL ANDA 32 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0904-6908 CAPSULE 40 mg ORAL ANDA 31 sections
STRATTERA HUMAN PRESCRIPTION DRUG LABEL 1 16590-337 CAPSULE 10 mg ORAL NDA 35 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-755 CAPSULE 10 mg ORAL ANDA 34 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-755 CAPSULE 10 mg ORAL ANDA 34 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-756 CAPSULE 18 mg ORAL ANDA 34 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-756 CAPSULE 18 mg ORAL ANDA 34 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-757 CAPSULE 25 mg ORAL ANDA 34 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-757 CAPSULE 25 mg ORAL ANDA 34 sections
atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 16714-758 CAPSULE 40 mg ORAL ANDA 34 sections