atenolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 255 29122-68-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • atenolol
  • (RS)-Atenolol
  • (+/-)-Atenolol
  • betablok
A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
  • Molecular weight: 266.34
  • Formula: C14H22N2O3
  • CLOGP: -0.11
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 84.58
  • ALOGS: -2.79
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
75 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 26.50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 94 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 12.50 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 56 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.95 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.94 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 19, 1981 FDA ALVOGEN IPCO SARL

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 650.85 9.69 834 149487 72393 63266308
Pemphigus 403.91 9.69 6 150315 183720 63154981
Systemic lupus erythematosus 340.06 9.69 46 150275 208872 63129829
Hand deformity 317.86 9.69 14 150307 159443 63179258
Maternal exposure during pregnancy 286.21 9.69 83 150238 219979 63118722
Glossodynia 284.95 9.69 42 150279 178834 63159867
Off label use 255.23 9.69 787 149534 673675 62665026
Pericarditis 245.38 9.69 17 150304 131562 63207139
Wound 215.13 9.69 60 150261 163203 63175498
Hypotension 208.44 9.69 1228 149093 271376 63067325
Cardiac failure congestive 204.58 9.69 580 149741 91853 63246848
Drug ineffective 204.38 9.69 1545 148776 1043220 62295481
Myocardial infarction 180.79 9.69 584 149737 99309 63239392
Duodenal ulcer perforation 172.61 9.69 8 150313 87201 63251500
Discomfort 168.79 9.69 93 150228 167281 63171420
Cerebrovascular accident 168.62 9.69 601 149720 107423 63231278
Sinus bradycardia 162.16 9.69 186 150135 14365 63324336
Drug intolerance 148.77 9.69 318 150003 308343 63030358
Treatment failure 146.48 9.69 153 150168 198890 63139811
Contraindicated product administered 144.27 9.69 182 150139 217466 63121235
Folliculitis 140.63 9.69 6 150315 70311 63268390
Coronary artery disease 139.24 9.69 264 150057 32113 63306588
Alopecia 136.52 9.69 381 149940 337155 63001546
Syncope 135.41 9.69 594 149727 116791 63221910
Atrial fibrillation 121.69 9.69 573 149748 116063 63222638
Muscle injury 120.19 9.69 9 150312 65336 63273365
Drug interaction 117.53 9.69 936 149385 228195 63110506
Hyponatraemia 116.21 9.69 549 149772 111351 63227350
Infusion related reaction 115.72 9.69 256 150065 245265 63093436
Electric shock 114.55 9.69 58 150263 1262 63337439
Swelling 113.41 9.69 308 150013 275070 63063631
Synovitis 113.06 9.69 167 150154 186751 63151950
Exposure during pregnancy 112.81 9.69 121 150200 155426 63183275
Abdominal discomfort 110.14 9.69 390 149931 320495 63018206
Infection 107.13 9.69 240 150081 228933 63109768
Product use in unapproved indication 106.36 9.69 162 150159 178918 63159783
Therapeutic product effect incomplete 105.16 9.69 85 150236 124971 63213730
Acute kidney injury 104.98 9.69 1018 149303 262397 63076304
Arthropathy 104.84 9.69 252 150069 234540 63104161
Intentional product use issue 103.76 9.69 90 150231 127802 63210899
Sleep disorder due to general medical condition, insomnia type 102.64 9.69 5 150316 52212 63286489
Nasopharyngitis 101.25 9.69 289 150032 253968 63084733
Hypertensive crisis 99.50 9.69 150 150171 15136 63323565
Hepatic enzyme increased 97.77 9.69 208 150113 202120 63136581
Therapeutic product effect decreased 96.38 9.69 195 150126 192992 63145709
Hypersensitivity 93.70 9.69 366 149955 292319 63046382
Dehydration 90.94 9.69 712 149609 172642 63166059
General physical health deterioration 89.23 9.69 217 150104 201185 63137516
Blister 82.42 9.69 112 150209 129702 63208999
Intervertebral discitis 79.66 9.69 64 150257 3164 63335537
Shock 79.12 9.69 173 150148 23290 63315411
Heart rate decreased 78.45 9.69 262 150059 45298 63293403
Dizziness 78.03 9.69 1440 148881 428485 62910216
Rheumatoid factor positive 77.91 9.69 52 150269 84354 63254347
Renal failure 77.78 9.69 511 149810 117141 63221560
Haematocrit decreased 77.55 9.69 237 150084 39103 63299598
Product use issue 76.95 9.69 266 150055 220254 63118447
Fall 70.08 9.69 1311 149010 391023 62947678
Pyrexia 66.51 9.69 753 149568 469725 62868976
Ill-defined disorder 63.35 9.69 60 150261 81695 63257006
Angina unstable 63.24 9.69 81 150240 7014 63331687
Hyperkalaemia 62.99 9.69 275 150046 53928 63284773
Neovascularisation 62.42 9.69 37 150284 1108 63337593
Acute myocardial infarction 61.89 9.69 192 150129 31932 63306769
Stomatitis 61.79 9.69 149 150172 138576 63200125
Gastrointestinal disorder 61.64 9.69 137 150184 131102 63207599
Device expulsion 60.96 9.69 6 150315 34916 63303785
Sinusitis 60.06 9.69 304 150017 226349 63112352
Product complaint 58.25 9.69 107 150214 12702 63325999
Coordination abnormal 57.60 9.69 111 150210 13662 63325039
Demyelination 57.01 9.69 76 150245 6844 63331857
Pain 56.74 9.69 1329 148992 739299 62599402
Blood pressure increased 56.66 9.69 610 149711 161452 63177249
Post-traumatic stress disorder 56.62 9.69 66 150255 5185 63333516
Completed suicide 56.47 9.69 560 149761 145113 63193588
Loss of employment 56.46 9.69 45 150276 2199 63336502
Helicobacter infection 55.96 9.69 83 150238 92702 63245999
Blood urea increased 54.90 9.69 162 150159 26217 63312484
Irritable bowel syndrome 54.45 9.69 69 150252 82343 63256358
Blood creatinine increased 52.95 9.69 373 149948 87471 63251230
Temperature intolerance 52.80 9.69 84 150237 8880 63329821
International normalised ratio increased 52.02 9.69 233 150088 46192 63292509
Lower respiratory tract infection 51.43 9.69 152 150169 132155 63206546
Liver injury 51.02 9.69 41 150280 60479 63278222
Asthma 50.71 9.69 145 150176 127416 63211285
Haemoglobin decreased 50.57 9.69 547 149774 144938 63193763
Red blood cell count decreased 50.15 9.69 210 150111 40435 63298266
Blood glucose increased 49.52 9.69 354 149967 83402 63255299
Live birth 48.67 9.69 3 150318 25627 63313074
Psoriatic arthropathy 48.55 9.69 89 150232 91431 63247270
Atrioventricular block first degree 48.23 9.69 72 150249 7201 63331500
Rash 47.00 9.69 992 149329 559879 62778822
Overdose 46.85 9.69 447 149874 114631 63224070
Joint swelling 45.61 9.69 526 149795 327140 63011561
Asthenia 44.79 9.69 1207 149114 382397 62956304
Chest pain 44.67 9.69 739 149582 215220 63123481
Frustration tolerance decreased 44.67 9.69 68 150253 6920 63331781
Blood pressure inadequately controlled 44.63 9.69 57 150264 4921 63333780
Transient ischaemic attack 44.21 9.69 192 150129 37561 63301140
Blood pressure systolic increased 43.09 9.69 224 150097 47173 63291528
Loss of consciousness 42.85 9.69 448 149873 117673 63221028
Sinus arrest 42.57 9.69 36 150285 1913 63336788
Hip arthroplasty 41.79 9.69 31 150290 47615 63291086
Coronary arterial stent insertion 39.98 9.69 41 150280 2788 63335913
Feeling abnormal 39.34 9.69 530 149791 147862 63190839
Blood glucose decreased 39.23 9.69 124 150197 20828 63317873
Myalgia 39.12 9.69 524 149797 146005 63192696
Exposure via ingestion 39.03 9.69 41 150280 2868 63335833
Mobility decreased 39.03 9.69 151 150170 121008 63217693
Condition aggravated 38.94 9.69 694 149627 401523 62937178
Hyperhidrosis 38.65 9.69 408 149913 107428 63231273
Knee arthroplasty 38.35 9.69 43 150278 54163 63284538
Palpitations 38.25 9.69 422 149899 112348 63226353
Drug resistance 37.38 9.69 5 150316 22928 63315773
Prescribed overdose 37.36 9.69 17 150304 34136 63304565
Lactic acidosis 36.94 9.69 184 150137 38103 63300598
Hypokalaemia 36.85 9.69 392 149929 103412 63235289
Lipase increased 36.85 9.69 76 150245 9824 63328877
Ventricular hypertrophy 36.73 9.69 43 150278 3393 63335308
Fibromyalgia 36.09 9.69 86 150235 80334 63258367
Rectal polyp 35.87 9.69 27 150294 1212 63337489
COVID-19 35.13 9.69 143 150178 112960 63225741
Oedema peripheral 35.03 9.69 637 149684 188874 63149827
Wheezing 34.89 9.69 113 150208 95482 63243219
Premature delivery 34.84 9.69 14 150307 30267 63308434
Angina pectoris 34.48 9.69 152 150169 29926 63308775
Post cholecystectomy syndrome 34.37 9.69 18 150303 421 63338280
Pregnancy 33.57 9.69 23 150298 36813 63301888
Hyperlipidaemia 33.20 9.69 112 150209 19459 63319242
Diabetes mellitus 33.05 9.69 236 150085 55574 63283127
Anuria 33.01 9.69 84 150237 12467 63326234
Febrile neutropenia 33.00 9.69 156 150165 118293 63220408
Femur fracture 32.36 9.69 189 150132 41567 63297134
Depression 32.06 9.69 648 149673 195844 63142857
Rhabdomyolysis 30.93 9.69 194 150127 43757 63294944
Melaena 30.77 9.69 148 150173 30217 63308484
Myelosuppression 30.66 9.69 9 150312 23694 63315007
Vulvovaginal burning sensation 30.60 9.69 31 150290 2078 63336623
Blood immunoglobulin A increased 29.54 9.69 20 150301 758 63337943
Coronary artery occlusion 29.46 9.69 62 150259 8129 63330572
Hospitalisation 29.39 9.69 103 150218 84978 63253723
Arteriosclerosis 29.26 9.69 70 150251 9996 63328705
Atrioventricular block complete 29.15 9.69 62 150259 8189 63330512
Haemodialysis 29.07 9.69 65 150256 8882 63329819
Aspartate aminotransferase 28.85 9.69 16 150305 421 63338280
Malignant neoplasm progression 28.64 9.69 99 150222 82022 63256679
Ulcer 28.47 9.69 130 150191 25977 63312724
Device dislocation 27.80 9.69 13 150308 25692 63313009
Fear of eating 27.67 9.69 15 150306 377 63338324
Poisoning 27.43 9.69 83 150238 13617 63325084
Abortion spontaneous 26.75 9.69 44 150277 47151 63291550
Musculoskeletal stiffness 26.58 9.69 294 150027 184324 63154377
Foetal exposure during pregnancy 26.51 9.69 22 150299 31940 63306761
Drug abuse 26.26 9.69 86 150235 72432 63266269
Multiple fractures 26.21 9.69 61 150260 8557 63330144
Blood pressure decreased 25.68 9.69 251 150070 64771 63273930
Cardiomegaly 24.93 9.69 95 150226 17519 63321182
Dilatation atrial 24.84 9.69 27 150294 1964 63336737
Duodenal ulcer 24.81 9.69 56 150265 7700 63331001
Arrhythmia 24.78 9.69 165 150156 37975 63300726
Metabolic acidosis 24.64 9.69 187 150134 44882 63293819
Paradoxical drug reaction 24.58 9.69 39 150282 4113 63334588
Change of bowel habit 24.38 9.69 28 150293 2165 63336536
Atrioventricular block 24.22 9.69 55 150266 7592 63331109
Vision blurred 24.21 9.69 328 149993 91596 63247105
Rhinalgia 24.11 9.69 24 150297 1575 63337126
Incorrect route of product administration 23.89 9.69 18 150303 27434 63311267
Balance disorder 23.81 9.69 305 150016 84117 63254584
Hypoglycaemia 23.78 9.69 232 150089 59833 63278868
Blood pressure immeasurable 23.37 9.69 21 150300 1211 63337490
Autoimmune disorder 23.19 9.69 6 150315 17171 63321530
Rectosigmoid cancer 23.11 9.69 10 150311 150 63338551
Product dose omission issue 23.04 9.69 403 149918 233910 63104791
Blood sodium decreased 23.00 9.69 116 150205 24136 63314565
Type 2 diabetes mellitus 22.95 9.69 76 150245 63792 63274909
Vulvovaginal pruritus 22.80 9.69 33 150288 3210 63335491
Granulocyte count increased 22.75 9.69 18 150303 870 63337831
Progressive multifocal leukoencephalopathy 22.68 9.69 75 150246 12896 63325805
Glomerular filtration rate increased 22.58 9.69 18 150303 880 63337821
Impaired quality of life 22.48 9.69 3 150318 13780 63324921
Nodal rhythm 22.38 9.69 24 150297 1719 63336982
Death 22.22 9.69 696 149625 373685 62965016
Rheumatoid arthritis 22.04 9.69 446 149875 253373 63085328
Lethargy 22.02 9.69 216 150105 55791 63282910
Confusion postoperative 21.91 9.69 11 150310 235 63338466
Drug dispensed to wrong patient 21.84 9.69 12 150309 310 63338391
Monoclonal B-cell lymphocytosis 21.68 9.69 7 150314 43 63338658
Phaeochromocytoma crisis 21.61 9.69 11 150310 242 63338459
Inappropriate antidiuretic hormone secretion 21.56 9.69 83 150238 15379 63323322
Angioedema 21.37 9.69 190 150131 47775 63290926
Phaeochromocytoma 21.29 9.69 14 150307 505 63338196
Hypertension 20.91 9.69 834 149487 278469 63060232
Hepatic steatosis 20.87 9.69 128 150193 28641 63310060
Fear 20.66 9.69 83 150238 15683 63323018
Blood potassium increased 20.59 9.69 92 150229 18217 63320484
Ventricular fibrillation 20.20 9.69 68 150253 11799 63326902
BRASH syndrome 20.09 9.69 13 150308 456 63338245
Jaundice 19.89 9.69 128 150193 29123 63309578
Sinus node dysfunction 19.89 9.69 38 150283 4647 63334054
Pulmonary oedema 19.83 9.69 208 150113 54665 63284036
Lacunar infarction 19.68 9.69 31 150290 3249 63335452
Pancreatitis 19.68 9.69 190 150131 48865 63289836
Myocardial ischaemia 19.57 9.69 71 150250 12788 63325913
Coronary artery bypass 19.49 9.69 26 150295 2343 63336358
Skull fracture 19.47 9.69 18 150303 1077 63337624
Dry mouth 19.36 9.69 275 150046 77588 63261113
Bronchiectasis 19.34 9.69 7 150314 16135 63322566
Anxiety 19.28 9.69 662 149659 216879 63121822
Product substitution issue 19.22 9.69 82 150239 15914 63322787
Bone erosion 19.10 9.69 9 150312 17708 63320993
Disease progression 19.08 9.69 192 150129 122566 63216135
Vitamin B12 increased 19.02 9.69 18 150303 1110 63337591
Neutrophil count decreased 19.00 9.69 69 150252 56337 63282364
Laryngotracheal oedema 18.99 9.69 6 150315 34 63338667
Emotional distress 18.90 9.69 137 150184 32412 63306289
Throat irritation 18.81 9.69 153 150168 37494 63301207
Cardiogenic shock 18.60 9.69 88 150233 17844 63320857
Disability 18.28 9.69 89 150232 18258 63320443
Impaired healing 18.25 9.69 155 150166 102387 63236314
Depressed level of consciousness 18.24 9.69 226 150095 61852 63276849
Device difficult to use 18.20 9.69 4 150317 12792 63325909
Mental status changes postoperative 17.98 9.69 9 150312 191 63338510
Presyncope 17.93 9.69 120 150201 27665 63311036
Cytomegalovirus infection 17.90 9.69 14 150307 20938 63317763
Rheumatoid factor increased 17.90 9.69 22 150299 1827 63336874
Stoma site haemorrhage 17.88 9.69 17 150304 1054 63337647
Renal tubular acidosis 17.80 9.69 21 150300 1671 63337030
Illness anxiety disorder 17.69 9.69 8 150313 134 63338567
Grip strength decreased 17.68 9.69 16 150305 22271 63316430
Purple glove syndrome 17.44 9.69 9 150312 204 63338497
Coma scale normal 17.43 9.69 4 150317 4 63338697
Carotid artery stenosis 17.29 9.69 38 150283 5132 63333569
Fatigue 17.22 9.69 1841 148480 886187 62452514
Muscular weakness 17.21 9.69 395 149926 121958 63216743
Neutropenia 17.19 9.69 301 150020 174704 63163997
Coronary artery stenosis 17.17 9.69 36 150285 4708 63333993
Productive cough 17.16 9.69 84 150237 63124 63275577
Blood pressure diastolic decreased 17.09 9.69 102 150219 22604 63316097
Bradyarrhythmia 17.07 9.69 23 150298 2092 63336609
Urine odour abnormal 17.05 9.69 43 150278 6346 63332355
Pseudopolyposis 17.05 9.69 5 150316 21 63338680
Cerebral haematoma 17.04 9.69 31 150290 3652 63335049
Urinary incontinence 17.03 9.69 132 150189 31882 63306819
Total lung capacity increased 16.96 9.69 24 150297 2286 63336415
Red blood cell sedimentation rate abnormal 16.95 9.69 92 150229 19690 63319011
Atrioventricular block second degree 16.93 9.69 32 150289 3882 63334819
Rectal haemorrhage 16.85 9.69 184 150137 48846 63289855
Dysphagia 16.78 9.69 299 150022 88286 63250415
Hallucination, visual 16.71 9.69 90 150231 19208 63319493
Vitamin B12 deficiency 16.64 9.69 38 150283 5265 63333436
Neurofibrosarcoma 16.59 9.69 8 150313 156 63338545
Blood triglycerides increased 16.57 9.69 66 150255 12422 63326279
Liver function test increased 16.44 9.69 33 150288 32778 63305923
Gingival hypertrophy 16.37 9.69 20 150301 1651 63337050
Electrocardiogram QRS complex abnormal 16.33 9.69 9 150312 234 63338467
Cardiac disorder 16.24 9.69 188 150133 50628 63288073
Pancreatitis acute 16.15 9.69 115 150206 27051 63311650
Hypomagnesaemia 16.14 9.69 120 150201 28617 63310084
Limb discomfort 16.07 9.69 123 150198 29593 63309108
Visceral congestion 16 9.69 10 150311 330 63338371
Therapy interrupted 15.96 9.69 33 150288 32422 63306279
Therapy partial responder 15.85 9.69 3 150318 10655 63328046
Renal artery stenosis 15.78 9.69 21 150300 1888 63336813
Gallbladder disorder 15.73 9.69 87 150234 18755 63319946
Purpura senile 15.70 9.69 12 150309 551 63338150
Unresponsive to stimuli 15.60 9.69 135 150186 33681 63305020
Multiple sclerosis 15.57 9.69 105 150216 24267 63314434
Vertigo 15.49 9.69 213 150108 59674 63279027
Lung diffusion test decreased 15.47 9.69 13 150308 685 63338016
Injection site discomfort 15.45 9.69 34 150287 4596 63334105
Resorption bone increased 15.41 9.69 17 150304 1257 63337444
Blood creatine phosphokinase increased 15.38 9.69 124 150197 30306 63308395
Bundle branch block left 15.31 9.69 44 150277 7015 63331686
Depressed mood 15.31 9.69 154 150167 40037 63298664
Furuncle 15.29 9.69 42 150279 6524 63332177
Breast cancer stage III 15.28 9.69 3 150318 10383 63328318
Adrenal insufficiency 15.14 9.69 83 150238 17832 63320869
High density lipoprotein decreased 15.14 9.69 22 150299 2148 63336553
Sleep disorder due to a general medical condition 15.09 9.69 5 150316 12183 63326518
Sinus arrhythmia 15.03 9.69 18 150303 1455 63337246
Bone disorder 14.92 9.69 94 150227 21232 63317469
Cardiac flutter 14.72 9.69 31 150290 4065 63334636
Epistaxis 14.69 9.69 248 150073 72477 63266224
Cystocele 14.56 9.69 16 150305 1178 63337523
Peak expiratory flow rate decreased 14.53 9.69 12 150309 617 63338084
Polyp 14.48 9.69 41 150280 6480 63332221
Blood chloride decreased 14.48 9.69 37 150284 5505 63333196
Weight increased 14.46 9.69 489 149832 260303 63078398
Haemorrhagic vasculitis 14.44 9.69 6 150315 81 63338620
Cardiac stress test abnormal 14.40 9.69 12 150309 625 63338076
Joint noise 14.37 9.69 32 150289 4360 63334341
Peripheral coldness 14.34 9.69 62 150259 12103 63326598
Pain in extremity 14.31 9.69 939 149382 330547 63008154
Circulatory collapse 14.30 9.69 95 150226 21843 63316858
Intracranial haematoma 14.29 9.69 10 150311 400 63338301
Joint range of motion decreased 14.29 9.69 35 150286 32393 63306308
Arteriosclerosis coronary artery 14.27 9.69 48 150273 8325 63330376
Blood catecholamines decreased 14.21 9.69 4 150317 14 63338687
Forced vital capacity decreased 14.11 9.69 15 150306 1064 63337637
Mitral valve incompetence 14.10 9.69 87 150234 19507 63319194
Chronic kidney disease 14.08 9.69 167 150154 45231 63293470
Diverticulum 14.05 9.69 61 150260 11930 63326771
C-reactive protein increased 14.02 9.69 308 150013 94399 63244302
Cyanosis 14.00 9.69 78 150243 16857 63321844
Ageusia 13.97 9.69 67 150254 13661 63325040
Lymphocyte count decreased 13.86 9.69 32 150289 30225 63308476
Drug hypersensitivity 13.82 9.69 598 149723 310089 63028612
Intestinal ischaemia 13.80 9.69 44 150277 7424 63331277
Malaise 13.70 9.69 1153 149168 414801 62923900
Increased appetite 13.68 9.69 52 150269 9578 63329123
Breast calcifications 13.67 9.69 16 150305 1262 63337439
Glomerulonephritis acute 13.57 9.69 6 150315 95 63338606
Adverse drug reaction 13.52 9.69 122 150199 79592 63259109
Hepatic function abnormal 13.48 9.69 44 150277 37098 63301603
Microgenia 13.42 9.69 4 150317 18 63338683
Tenosynovitis 13.41 9.69 8 150313 13787 63324914
Confusional state 13.35 9.69 686 149635 235694 63103007
Urinary tract infection 13.33 9.69 760 149561 263924 63074777
Fasting 13.24 9.69 4 150317 19 63338682
Haematotoxicity 13.20 9.69 3 150318 9373 63329328
Peripheral swelling 13.08 9.69 506 149815 265436 63073265
Optic disc haemorrhage 13.03 9.69 6 150315 105 63338596
Product residue present 13.03 9.69 29 150292 3950 63334751
Swelling face 13.02 9.69 217 150104 63258 63275443
Anhedonia 12.99 9.69 56 150265 10918 63327783
Colon cancer 12.94 9.69 52 150269 9826 63328875
Thyrotoxic crisis 12.94 9.69 13 150308 863 63337838
Laryngeal pain 12.77 9.69 31 150290 4467 63334234
Cardiac arrest 12.77 9.69 298 150023 92247 63246454
Heavy menstrual bleeding 12.68 9.69 14 150307 17759 63320942
Caesarean section 12.61 9.69 13 150308 17019 63321682
Respiratory depression 12.59 9.69 65 150256 13650 63325051
Dysphonia 12.58 9.69 170 150151 47444 63291257
Intestinal haemorrhage 12.55 9.69 28 150293 3819 63334882
Ischaemic stroke 12.47 9.69 79 150242 17878 63320823
Lip dry 12.40 9.69 11 150310 15459 63323242
Mucosal inflammation 12.37 9.69 63 150258 46865 63291836
Supraventricular extrasystoles 12.37 9.69 31 150290 4558 63334143
Yawning 12.36 9.69 14 150307 1066 63337635
Cytopenia 12.34 9.69 6 150315 11595 63327106
Product substitution error 12.33 9.69 4 150317 25 63338676
Cerebellar haematoma 12.31 9.69 9 150312 386 63338315
Muscle spasms 12.31 9.69 469 149852 155681 63183020
Blood osmolarity decreased 12.31 9.69 13 150308 915 63337786
Colorectal adenocarcinoma 12.31 9.69 6 150315 120 63338581
Vitamin D deficiency 12.17 9.69 65 150256 13827 63324874
Laryngospasm 12.17 9.69 24 150297 3004 63335697
Hyperglycaemia 12.11 9.69 152 150169 41715 63296986
Hepatotoxicity 12.02 9.69 46 150275 36995 63301706
Dysdiadochokinesis 12.00 9.69 6 150315 127 63338574
Dystrophic calcification 11.96 9.69 6 150315 128 63338573
Contrast media reaction 11.90 9.69 14 150307 1111 63337590
Cerebral ischaemia 11.85 9.69 39 150282 6689 63332012
Diastolic dysfunction 11.84 9.69 38 150283 6433 63332268
Musculoskeletal discomfort 11.83 9.69 78 150243 17889 63320812
Renal injury 11.82 9.69 49 150272 9390 63329311
Autoimmune nephritis 11.78 9.69 9 150312 413 63338288
Dysuria 11.77 9.69 127 150194 33611 63305090
Rash pustular 11.76 9.69 41 150280 7241 63331460
Disorientation 11.74 9.69 144 150177 39308 63299393
Muscle spasticity 11.73 9.69 21 150300 21773 63316928
Gastrointestinal haemorrhage 11.70 9.69 263 150058 80913 63257788
Cardiac neoplasm unspecified 11.68 9.69 5 150316 73 63338628
Upper respiratory tract infection 11.66 9.69 131 150190 81916 63256785
Postoperative wound infection 11.62 9.69 54 150267 10871 63327830
Renal artery fibromuscular dysplasia 11.55 9.69 3 150318 7 63338694
Gilbert's syndrome 11.55 9.69 3 150318 7 63338694
Sputum discoloured 11.52 9.69 13 150308 16334 63322367
Night sweats 11.52 9.69 68 150253 48746 63289955
Cutaneous lupus erythematosus 11.51 9.69 22 150299 2690 63336011
Entropion 11.50 9.69 5 150316 76 63338625
Blood potassium decreased 11.49 9.69 151 150170 41875 63296826
Adenocarcinoma of colon 11.49 9.69 21 150300 2483 63336218
IIIrd nerve paresis 11.43 9.69 6 150315 141 63338560
Pneumocystis jirovecii pneumonia 11.34 9.69 14 150307 16900 63321801
Peau d'orange 11.32 9.69 6 150315 144 63338557
Tarsal tunnel syndrome 11.32 9.69 10 150311 564 63338137
Intramedullary rod insertion 11.29 9.69 19 150302 2104 63336597
Interstitial lung disease 11.28 9.69 93 150228 61815 63276886
Peripheral venous disease 11.25 9.69 12 150309 15465 63323236
Gestational diabetes 11.21 9.69 3 150318 8393 63330308
Premature labour 11.14 9.69 8 150313 12496 63326205
Pulmonary arterial hypertension 11.06 9.69 23 150298 22554 63316147
Haemorrhoids 11.06 9.69 90 150231 22060 63316641
Gastric ulcer haemorrhage 11.04 9.69 31 150290 4877 63333824
Extrasystoles 11.03 9.69 32 150289 5128 63333573
Electrocardiogram ST-T change 10.91 9.69 13 150308 1045 63337656
Saliva discolouration 10.88 9.69 4 150317 38 63338663
Ventricular dysfunction 10.87 9.69 22 150299 2806 63335895
Transplant rejection 10.84 9.69 6 150315 10774 63327927
Swollen tongue 10.79 9.69 128 150193 34672 63304029
Blood alkaline phosphatase increased 10.77 9.69 152 150169 42815 63295886
Mediastinal haemorrhage 10.77 9.69 3 150318 10 63338691
Vertigo positional 10.75 9.69 22 150299 2827 63335874
Torsade de pointes 10.71 9.69 61 150260 13290 63325411
Cardiac valve disease 10.71 9.69 28 150293 4224 63334477
Weight decreased 10.70 9.69 777 149544 276021 63062680
Miosis 10.69 9.69 40 150281 7313 63331388
Retinal vein thrombosis 10.60 9.69 9 150312 481 63338220
Quadriparesis 10.58 9.69 18 150303 2011 63336690
Nervousness 10.53 9.69 116 150205 30863 63307838
Rhythm idioventricular 10.49 9.69 7 150314 259 63338442
Ventricular extrasystoles 10.46 9.69 55 150266 11632 63327069
Low density lipoprotein increased 10.45 9.69 36 150285 6321 63332380
Intentional product misuse 10.43 9.69 93 150228 60824 63277877
Proctalgia 10.39 9.69 35 150286 6075 63332626
Nasal dryness 10.37 9.69 29 150292 4552 63334149
Nausea 10.28 9.69 2229 148092 852242 62486459
Female sexual arousal disorder 10.28 9.69 4 150317 45 63338656
Blood uric acid increased 10.26 9.69 32 150289 5335 63333366
Ear infection 10.25 9.69 51 150270 38162 63300539
Gout 10.24 9.69 60 150261 13211 63325490
Tubular breast carcinoma 10.20 9.69 4 150317 46 63338655
Vascular access site pain 10.12 9.69 5 150316 103 63338598
Gastric ulcer 10.09 9.69 94 150227 23943 63314758
Breath sounds abnormal 10.07 9.69 52 150269 10921 63327780
Concussion 10.06 9.69 46 150275 9198 63329503
Supraventricular tachycardia 10.04 9.69 63 150258 14208 63324493
Respiratory disorder 10.00 9.69 53 150268 39029 63299672
Nodal arrhythmia 9.93 9.69 13 150308 1150 63337551
Chorioretinal disorder 9.87 9.69 5 150316 109 63338592
Azotaemia 9.82 9.69 28 150293 4443 63334258
Ear, nose and throat examination abnormal 9.81 9.69 3 150318 15 63338686
Halo vision 9.79 9.69 8 150313 405 63338296
Stridor 9.76 9.69 24 150297 3486 63335215
Somnolence 9.76 9.69 517 149804 178168 63160533
Vulvovaginal discomfort 9.74 9.69 19 150302 2359 63336342
Continuous haemodiafiltration 9.74 9.69 12 150309 999 63337702
International normalised ratio decreased 9.71 9.69 28 150293 4473 63334228

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 520.03 10.27 824 95632 74594 34785881
Off label use 322.87 10.27 412 96044 419112 34441363
Myocardial infarction 268.94 10.27 839 95617 120246 34740229
Completed suicide 203.94 10.27 665 95791 97503 34762972
Coronary artery disease 194.62 10.27 419 96037 47886 34812589
Sinus bradycardia 181.88 10.27 201 96255 12762 34847713
Syncope 123.60 10.27 540 95916 90911 34769564
Hypotension 122.03 10.27 1035 95421 220614 34639861
Product use in unapproved indication 119.16 10.27 90 96366 117409 34743066
Cardiac failure congestive 110.46 10.27 489 95967 82781 34777694
Drug abuse 99.06 10.27 77 96379 99019 34761456
Cerebrovascular accident 86.53 10.27 462 95994 84349 34776126
Drug ineffective 85.87 10.27 827 95629 455924 34404551
Febrile neutropenia 84.85 10.27 155 96301 136694 34723781
Death 82.93 10.27 702 95754 397347 34463128
Angina unstable 82.42 10.27 129 96327 11524 34848951
Rhabdomyolysis 74.12 10.27 378 96078 67785 34792690
COVID-19 74.07 10.27 63 96393 77487 34782988
Chest pain 73.35 10.27 599 95857 126163 34734312
Acute myocardial infarction 72.35 10.27 317 96139 53402 34807073
Intentional product use issue 71.32 10.27 38 96418 59778 34800697
Angina pectoris 70.97 10.27 219 96237 31144 34829331
Pyrexia 70.31 10.27 585 95871 332428 34528047
Neutropenia 57.51 10.27 230 96226 156548 34703927
Condition aggravated 57.43 10.27 304 96152 191892 34668583
Hyperkalaemia 56.41 10.27 356 96100 69033 34791442
IgM nephropathy 55.67 10.27 19 96437 119 34860356
Orthostatic hypotension 53.17 10.27 175 96281 25744 34834731
Injury 52.05 10.27 150 96306 20537 34839938
Foetal exposure during pregnancy 51.98 10.27 20 96436 38081 34822394
Dizziness 50.84 10.27 866 95590 217655 34642820
Acute kidney injury 48.36 10.27 1141 95315 303847 34556628
Coronary artery occlusion 47.48 10.27 98 96358 10864 34849611
Atrioventricular block first degree 46.68 10.27 70 96386 6022 34854453
Myocardial ischaemia 45.52 10.27 128 96328 17280 34843195
Coronary artery bypass 44.42 10.27 61 96395 4841 34855634
Treatment failure 43.28 10.27 39 96417 46658 34813817
Myalgia 43.09 10.27 387 96069 83723 34776752
Coronary arterial stent insertion 42.99 10.27 55 96401 4074 34856401
Confusional state 40.17 10.27 589 95867 143571 34716904
Therapeutic product effect incomplete 39.25 10.27 49 96407 50492 34809983
Blood pressure inadequately controlled 38.87 10.27 42 96414 2598 34857877
Drug resistance 36.39 10.27 13 96443 25914 34834561
Palpitations 36.19 10.27 211 96245 39775 34820700
Pneumonia 36.19 10.27 745 95711 361882 34498593
Atrioventricular block 36 10.27 73 96383 7990 34852485
Wrong drug 35.46 10.27 12 96444 73 34860402
Emotional distress 34.98 10.27 106 96350 14920 34845555
Sinus node dysfunction 34.25 10.27 50 96406 4199 34856276
Asthenia 34.18 10.27 902 95554 244349 34616126
Coordination abnormal 33.88 10.27 69 96387 7575 34852900
Atrioventricular block complete 31.01 10.27 75 96381 9244 34851231
Sepsis 30.91 10.27 302 96154 166259 34694216
Plasmapheresis 30.77 10.27 16 96440 314 34860161
Hospitalisation 30.50 10.27 70 96386 56832 34803643
General physical health deterioration 28.95 10.27 221 96235 128048 34732427
Coronary artery stenosis 28.44 10.27 74 96382 9542 34850933
Malignant spinal cord compression 28.29 10.27 12 96444 145 34860330
Transient ischaemic attack 27.83 10.27 150 96306 27463 34833012
Product use issue 27.65 10.27 86 96370 63130 34797345
Paraplegia 27.55 10.27 37 96419 2874 34857601
Drug intolerance 27.53 10.27 79 96377 59491 34800984
Infusion related reaction 27.06 10.27 67 96389 52990 34807485
Paroxysmal atrioventricular block 26.95 10.27 6 96450 3 34860472
Shock 26.89 10.27 135 96321 24044 34836431
Cytokine release syndrome 26.58 10.27 15 96441 22862 34837613
Contraindicated product administered 26.56 10.27 13 96443 21468 34839007
Fear 26.39 10.27 76 96380 10400 34850075
Pacemaker generated rhythm 25.77 10.27 9 96447 61 34860414
International normalised ratio increased 25.38 10.27 220 96236 47107 34813368
Anhedonia 25.19 10.27 61 96395 7524 34852951
Myelosuppression 24.84 10.27 11 96445 19254 34841221
Nodal arrhythmia 24.64 10.27 20 96436 858 34859617
Product dose omission issue 23.93 10.27 213 96243 119498 34740977
Loss of consciousness 23.88 10.27 340 96116 82327 34778148
Mucosal inflammation 23.67 10.27 44 96412 38578 34821897
Swelling face 23.61 10.27 126 96330 22979 34837496
Product complaint 23.58 10.27 51 96405 5839 34854636
Blood glucose increased 23.27 10.27 284 96172 66434 34794041
Vasculitic rash 23.10 10.27 20 96436 939 34859536
Haemophagocytic lymphohistiocytosis 23.04 10.27 4 96452 12969 34847506
Blood creatine phosphokinase increased 22.75 10.27 206 96250 44651 34815824
Antiacetylcholine receptor antibody positive 22.56 10.27 8 96448 57 34860418
Circulatory collapse 22.37 10.27 116 96340 20922 34839553
Drop attacks 22.37 10.27 16 96440 567 34859908
Encapsulating peritoneal sclerosis 22.22 10.27 16 96440 573 34859902
Diverticulum 22.11 10.27 56 96400 7103 34853372
Optic ischaemic neuropathy 22.10 10.27 28 96428 2054 34858421
Drug ineffective for unapproved indication 21.74 10.27 20 96436 23695 34836780
Hypovolaemia 21.36 10.27 65 96391 9169 34851306
Metabolic acidosis 21.35 10.27 199 96257 43481 34816994
Leukopenia 21.29 10.27 95 96361 62761 34797714
Lethargy 20.93 10.27 189 96267 40933 34819542
Renal injury 20.68 10.27 73 96383 11122 34849353
Pulmonary oedema 20.52 10.27 211 96245 47318 34813157
Rheumatoid arthritis 20.52 10.27 47 96409 38191 34822284
Neutrophil count decreased 19.97 10.27 73 96383 51031 34809444
Pulmonary fibrosis 19.96 10.27 102 96354 18294 34842181
Diabetic neuropathy 19.94 10.27 39 96417 4158 34856317
Allergy to animal 19.90 10.27 13 96443 396 34860079
COVID-19 pneumonia 19.89 10.27 11 96445 16956 34843519
Presyncope 19.52 10.27 104 96352 18955 34841520
C-reactive protein increased 19.40 10.27 80 96376 54018 34806457
Arteriosclerosis coronary artery 19.39 10.27 77 96379 12408 34848067
Hypertension 19.29 10.27 503 95953 135940 34724535
Oedema peripheral 19.12 10.27 449 96007 119363 34741112
Heart rate decreased 18.85 10.27 151 96305 31594 34828881
Drug interaction 18.77 10.27 782 95674 225164 34635311
Erectile dysfunction 18.73 10.27 109 96347 20528 34839947
Renal failure 18.66 10.27 482 95974 130075 34730400
Ventricular hypertrophy 18.57 10.27 40 96416 4567 34855908
Cardiac arrest 18.42 10.27 370 96086 95789 34764686
Inappropriate schedule of product administration 18.30 10.27 99 96357 62197 34798278
Tongue oedema 18.24 10.27 31 96425 2966 34857509
Guillain-Barre syndrome 18.17 10.27 47 96409 6040 34854435
Hyperlactacidaemia 18.09 10.27 31 96425 2985 34857490
Hyponatraemia 17.83 10.27 324 96132 82367 34778108
Cytomegalovirus infection 17.64 10.27 28 96428 26107 34834368
Iron binding capacity total increased 17.52 10.27 6 96450 38 34860437
Acute coronary syndrome 17.51 10.27 79 96377 13466 34847009
Atrial fibrillation 17.24 10.27 451 96005 121942 34738533
Blood cholesterol increased 17.05 10.27 106 96350 20437 34840038
Hypertensive crisis 16.98 10.27 58 96398 8693 34851782
Dyskinesia oesophageal 16.01 10.27 6 96450 51 34860424
Abdominal compartment syndrome 15.52 10.27 16 96440 937 34859538
Blood creatinine increased 15.48 10.27 357 96099 94619 34765856
Vascular graft 15.42 10.27 20 96436 1502 34858973
Cerebral haematoma 15.20 10.27 37 96419 4578 34855897
Therapy partial responder 14.97 10.27 4 96452 9612 34850863
Immune reconstitution inflammatory syndrome 14.91 10.27 3 96453 8756 34851719
Vertigo 14.90 10.27 121 96335 25415 34835060
Toxic epidermal necrolysis 14.79 10.27 23 96433 21623 34838852
Nail pigmentation 14.75 10.27 7 96449 112 34860363
Hypophagia 14.66 10.27 115 96341 23907 34836568
Fall 14.60 10.27 692 95764 202193 34658282
Neurotoxicity 14.47 10.27 17 96439 17993 34842482
Atrioventricular block second degree 14.26 10.27 32 96424 3756 34856719
Nasopharyngitis 14.19 10.27 124 96332 69844 34790631
Anxiety 14.18 10.27 367 96089 99061 34761414
Hyperglycaemia 14.17 10.27 169 96287 39311 34821164
Hyperlipidaemia 14.01 10.27 78 96378 14451 34846024
Influenza 14.00 10.27 80 96376 49586 34810889
Disease progression 13.91 10.27 212 96244 107865 34752610
Retinal infarction 13.91 10.27 7 96449 128 34860347
Electrocardiogram QRS complex prolonged 13.80 10.27 37 96419 4857 34855618
Blood pressure increased 13.69 10.27 329 96127 87773 34772702
Drug dependence 13.62 10.27 29 96427 24188 34836287
Ventricular dysfunction 13.61 10.27 32 96424 3873 34856602
Pulse absent 13.57 10.27 41 96415 5762 34854713
Angioedema 13.42 10.27 160 96296 37214 34823261
Therapeutic product effect decreased 13.33 10.27 50 96406 34693 34825782
Anuria 13.00 10.27 60 96396 10325 34850150
Ischaemic cardiomyopathy 12.97 10.27 43 96413 6346 34854129
Asthma 12.96 10.27 67 96389 42589 34817886
Abnormal dreams 12.80 10.27 48 96408 7530 34852945
Synovitis 12.73 10.27 12 96444 14054 34846421
Poisoning 12.71 10.27 67 96389 12159 34848316
Pseudodementia 12.62 10.27 3 96453 3 34860472
Food aversion 12.52 10.27 10 96446 419 34860056
Dehydration 12.46 10.27 457 95999 129512 34730963
Pulmonary valve incompetence 12.46 10.27 14 96442 905 34859570
Hypoglycaemia 12.45 10.27 216 96240 54424 34806051
Blood pressure immeasurable 12.41 10.27 14 96442 909 34859566
Thrombotic microangiopathy 12.31 10.27 7 96449 10623 34849852
Hepatic function abnormal 12.21 10.27 72 96384 44291 34816184
Cardiac failure 12.08 10.27 178 96278 91070 34769405
Intentional product misuse 12.05 10.27 75 96381 45536 34814939
Myocarditis 12.00 10.27 12 96444 13670 34846805
Hypomagnesaemia 11.93 10.27 102 96354 21749 34838726
Malignant neoplasm progression 11.92 10.27 171 96285 87875 34772600
Gastric ulcer 11.91 10.27 79 96377 15571 34844904
Pseudomonas infection 11.88 10.27 10 96446 12372 34848103
Itching scar 11.87 10.27 4 96452 24 34860451
Nitritoid reaction 11.87 10.27 4 96452 24 34860451
Infection 11.81 10.27 178 96278 90737 34769738
Nodal rhythm 11.66 10.27 17 96439 1426 34859049
Bronchopulmonary aspergillosis 11.60 10.27 14 96442 14645 34845830
Dupuytren's contracture 11.41 10.27 3 96453 6 34860469
Cardio-respiratory arrest 11.36 10.27 215 96241 55058 34805417
Non-small cell lung cancer stage IIIB 11.34 10.27 4 96452 28 34860447
Aldolase increased 11.33 10.27 5 96451 67 34860408
Duodenitis 11.18 10.27 34 96422 4794 34855681
Haemodialysis 11.16 10.27 58 96398 10468 34850007
Tachypnoea 11.16 10.27 21 96435 18331 34842144
Mitral valve incompetence 11.11 10.27 75 96381 14868 34845607
Spermatozoa progressive motility decreased 11.01 10.27 6 96450 130 34860345
Spermatozoa progressive motility abnormal 10.99 10.27 4 96452 31 34860444
Renal arteriosclerosis 10.96 10.27 7 96449 205 34860270
Bladder irritation 10.94 10.27 5 96451 73 34860402
Sinoatrial block 10.93 10.27 10 96446 505 34859970
Abscess 10.79 10.27 10 96446 11807 34848668
Pneumocystis jirovecii pneumonia 10.76 10.27 24 96432 19686 34840789
Crystal urine 10.70 10.27 5 96451 77 34860398
Primary hyperaldosteronism 10.70 10.27 5 96451 77 34860398
Epididymitis 10.67 10.27 22 96434 2437 34858038
Premature baby 10.64 10.27 24 96432 19609 34840866
Illness 10.62 10.27 13 96443 13516 34846959
Labile hypertension 10.59 10.27 5 96451 79 34860396
Blood pressure fluctuation 10.58 10.27 35 96421 25214 34835261
Ultrasound Doppler abnormal 10.55 10.27 3 96453 9 34860466
Colitis 10.53 10.27 61 96395 37689 34822786
Seizure 10.52 10.27 215 96241 104642 34755833
Drug reaction with eosinophilia and systemic symptoms 10.52 10.27 51 96405 32961 34827514
Thyrotoxic periodic paralysis 10.50 10.27 6 96450 143 34860332
Anticoagulation drug level above therapeutic 10.46 10.27 20 96436 2096 34858379
Aspergillus infection 10.46 10.27 11 96445 12243 34848232
Carotid artery stenosis 10.39 10.27 34 96422 4985 34855490
Gravitational oedema 10.33 10.27 11 96445 669 34859806
Clostridium difficile infection 10.32 10.27 23 96433 18875 34841600
Peripheral vascular disorder 10.32 10.27 34 96422 5002 34855473
QRS axis abnormal 10.31 10.27 15 96441 1256 34859219
Product substitution issue 10.28 10.27 55 96401 10040 34850435
Ocular myasthenia 10.28 10.27 7 96449 229 34860246
Cardiac valve disease 10.27 10.27 25 96431 3093 34857382

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 1090.16 9.64 1517 199353 134040 79409478
Off label use 472.97 9.64 988 199882 906227 78637291
Myocardial infarction 429.03 9.64 1224 199646 182905 79360613
Coronary artery disease 328.69 9.64 591 200279 64883 79478635
Cardiac failure congestive 306.02 9.64 920 199950 141482 79402036
Sinus bradycardia 302.19 9.64 345 200525 24902 79518616
Hypotension 299.23 9.64 2015 198855 438302 79105216
Completed suicide 267.77 9.64 1277 199593 244490 79299028
Cerebrovascular accident 242.58 9.64 901 199969 154391 79389127
Pemphigus 222.59 9.64 6 200864 99576 79443942
Syncope 222.59 9.64 969 199901 178480 79365038
Hand deformity 212.93 9.64 12 200858 103907 79439611
Maternal exposure during pregnancy 188.32 9.64 55 200815 136483 79407035
Systemic lupus erythematosus 184.06 9.64 40 200830 121109 79422409
Product use in unapproved indication 183.63 9.64 216 200654 250143 79293375
Pericarditis 178.91 9.64 25 200845 104211 79439307
Drug ineffective 166.04 9.64 1834 199036 1079079 78464439
Acute kidney injury 154.06 9.64 1990 198880 517414 79026104
Intentional product use issue 149.03 9.64 100 200770 152012 79391506
Glossodynia 134.69 9.64 46 200824 103291 79440227
Pyrexia 131.34 9.64 1087 199783 677622 78865896
Angina unstable 128.16 9.64 182 200688 16345 79527173
Drug interaction 125.21 9.64 1596 199274 413587 79129931
Duodenal ulcer perforation 123.26 9.64 12 200858 66199 79477319
Acute myocardial infarction 121.05 9.64 448 200422 76588 79466930
Febrile neutropenia 119.26 9.64 252 200618 230747 79312771
Hypertensive crisis 119.23 9.64 199 200671 20571 79522947
Hyperkalaemia 115.50 9.64 582 200288 113816 79429702
Wound 114.30 9.64 76 200794 116103 79427415
Therapeutic product effect incomplete 111.73 9.64 115 200755 141530 79401988
Hyponatraemia 110.44 9.64 797 200073 177051 79366467
Rhabdomyolysis 110.03 9.64 533 200337 102598 79440920
Nasopharyngitis 108.97 9.64 305 200565 253576 79289942
Discomfort 107.24 9.64 95 200775 125522 79417996
Drug abuse 105.25 9.64 154 200716 162537 79380981
Drug intolerance 103.50 9.64 331 200539 263788 79279730
Folliculitis 103.19 9.64 10 200860 55370 79488148
Shock 102.68 9.64 291 200579 43257 79500261
Electric shock 102.60 9.64 56 200814 1338 79542180
Angina pectoris 102.43 9.64 325 200545 51407 79492111
Atrial fibrillation 101.89 9.64 849 200021 197037 79346481
General physical health deterioration 101.64 9.64 354 200516 274884 79268634
Infection 99.62 9.64 296 200574 241416 79302102
Treatment failure 97.51 9.64 175 200695 170311 79373207
Atrioventricular block first degree 94.57 9.64 136 200734 12355 79531163
Dizziness 93.08 9.64 1851 199019 524590 79018928
Muscle injury 92.54 9.64 8 200862 48553 79494965
Infusion related reaction 90.57 9.64 288 200582 229949 79313569
Coordination abnormal 87.76 9.64 157 200713 17155 79526363
Coronary arterial stent insertion 86.94 9.64 91 200779 5953 79537565
COVID-19 83.89 9.64 169 200701 157505 79386013
Condition aggravated 81.44 9.64 838 200032 500286 79043232
Sleep disorder due to general medical condition, insomnia type 80.79 9.64 8 200862 43548 79499970
Renal failure 80.05 9.64 816 200054 200152 79343366
Chest pain 79.86 9.64 1073 199797 281231 79262287
Hypersensitivity 77.49 9.64 368 200502 261871 79281647
Exposure during pregnancy 76.52 9.64 85 200785 101047 79442471
Synovitis 74.82 9.64 168 200702 150566 79392952
International normalised ratio increased 73.19 9.64 413 200457 84308 79459210
Heart rate decreased 71.83 9.64 359 200511 69957 79473561
Blood pressure inadequately controlled 71.53 9.64 83 200787 6094 79537424
Therapeutic product effect decreased 70.91 9.64 196 200674 163667 79379851
Dehydration 70.45 9.64 944 199926 247243 79296275
Neutropenia 69.95 9.64 431 200439 287279 79256239
Contraindicated product administered 69.24 9.64 187 200683 157351 79386167
Stomatitis 68.49 9.64 169 200701 146588 79396930
Sinusitis 68.46 9.64 257 200613 195244 79348274
Alopecia 68.14 9.64 325 200545 231030 79312488
Transient ischaemic attack 67.88 9.64 288 200582 52407 79491111
Coronary artery occlusion 62.92 9.64 127 200743 15188 79528330
Fall 61.34 9.64 1635 199235 485994 79057524
Blister 60.24 9.64 132 200738 119344 79424174
Asthenia 59.67 9.64 1699 199171 509990 79033528
Asthma 59.63 9.64 160 200710 134935 79408583
Intervertebral discitis 59.50 9.64 67 200803 4761 79538757
Hepatic enzyme increased 58.27 9.64 249 200621 182361 79361157
Drug resistance 58.18 9.64 17 200853 42196 79501322
Myalgia 57.67 9.64 718 200152 184923 79358595
Confusional state 57.38 9.64 1122 199748 316875 79226643
IgM nephropathy 57.37 9.64 19 200851 119 79543399
Haematocrit decreased 57.05 9.64 305 200565 61007 79482511
Myocardial ischaemia 56.75 9.64 167 200703 25352 79518166
Swelling 56.18 9.64 318 200552 216393 79327125
Atrioventricular block complete 55.87 9.64 127 200743 16483 79527035
Neovascularisation 55.00 9.64 36 200834 1209 79542309
Loss of consciousness 53.21 9.64 652 200218 167291 79376227
Death 52.50 9.64 1059 199811 565455 78978063
Atrioventricular block 52.48 9.64 112 200758 13929 79529589
Myelosuppression 52.39 9.64 18 200852 40278 79503240
Ventricular hypertrophy 51.73 9.64 75 200795 6863 79536655
Blood creatinine increased 51.32 9.64 607 200263 154450 79389068
Post-traumatic stress disorder 50.61 9.64 62 200808 4819 79538699
Product complaint 49.34 9.64 106 200764 13243 79530275
Blood glucose increased 49.22 9.64 474 200396 114501 79429017
Lactic acidosis 48.75 9.64 324 200546 70035 79473483
Loss of employment 48.48 9.64 45 200825 2542 79540976
Palpitations 47.97 9.64 509 200361 126101 79417417
Metabolic acidosis 47.85 9.64 364 200506 82165 79461353
Poisoning 47.51 9.64 156 200714 25116 79518402
Coronary artery bypass 47.36 9.64 67 200803 5995 79537523
Orthostatic hypotension 46.67 9.64 271 200599 55893 79487625
Product use issue 45.59 9.64 325 200545 209497 79334021
Demyelination 44.89 9.64 76 200794 7947 79535571
Device expulsion 44.84 9.64 6 200864 25855 79517663
Sinus node dysfunction 44.48 9.64 74 200796 7627 79535891
Pneumonia 43.97 9.64 1297 199573 658949 78884569
Abdominal discomfort 43.69 9.64 412 200458 250315 79293203
Cytomegalovirus infection 43.15 9.64 27 200843 42617 79500901
Exposure via ingestion 43.13 9.64 59 200811 5115 79538403
Hypertension 42.76 9.64 1114 199756 329878 79213640
Arthropathy 42.66 9.64 266 200604 176845 79366673
Rheumatoid factor positive 42.36 9.64 53 200817 59786 79483732
Irritable bowel syndrome 42.13 9.64 57 200813 62184 79481334
Ill-defined disorder 41.95 9.64 63 200807 65812 79477706
Coronary artery stenosis 41.49 9.64 95 200775 12389 79531129
Fibromyalgia 41.49 9.64 61 200809 64279 79479239
Emotional distress 41.48 9.64 205 200665 39764 79503754
Mucosal inflammation 41.05 9.64 80 200790 75500 79468018
Sinus arrest 40.82 9.64 48 200822 3574 79539944
Hyperlipidaemia 40.34 9.64 151 200719 25942 79517576
Psoriatic arthropathy 40.29 9.64 85 200785 77914 79465604
Overdose 40.26 9.64 670 200200 183536 79359982
Anuria 39.94 9.64 130 200740 20833 79522685
Hospitalisation 39.80 9.64 114 200756 94122 79449396
Rectal polyp 39.06 9.64 33 200837 1644 79541874
Product dose omission issue 38.87 9.64 417 200453 247120 79296398
Blood pressure increased 38.50 9.64 747 200123 210613 79332905
Blood urea increased 38.34 9.64 232 200638 48558 79494960
Lethargy 38.24 9.64 342 200528 80950 79462568
Neutrophil count decreased 37.99 9.64 116 200754 93843 79449675
Hypokalaemia 37.63 9.64 540 200330 143500 79400018
Circulatory collapse 37.54 9.64 191 200679 37477 79506041
Haemodialysis 36.74 9.64 115 200755 18053 79525465
Pulmonary oedema 35.89 9.64 360 200510 87894 79455624
Temperature intolerance 35.80 9.64 77 200793 9628 79533890
Hypoglycaemia 35.52 9.64 402 200468 101192 79442326
Frustration tolerance decreased 35.45 9.64 66 200804 7436 79536082
Oedema peripheral 34.29 9.64 855 200015 251433 79292085
Blood potassium increased 33.90 9.64 155 200715 29120 79514398
Blood pressure systolic increased 33.16 9.64 285 200585 66701 79476817
Blood creatine phosphokinase increased 33.14 9.64 282 200588 65808 79477710
Fear 32.97 9.64 126 200744 21860 79521658
Melaena 32.77 9.64 264 200606 60626 79482892
Diverticulum 32.66 9.64 97 200773 14799 79528719
Blood pressure immeasurable 32.65 9.64 33 200837 2071 79541447
Joint swelling 32.21 9.64 522 200348 288124 79255394
Cytokine release syndrome 32.21 9.64 26 200844 35972 79507546
Fear of eating 32.07 9.64 18 200852 455 79543063
Aspergillus infection 31.93 9.64 5 200865 19156 79524362
Depression 31.66 9.64 742 200128 216048 79327470
Cerebral haematoma 31.61 9.64 65 200805 7877 79535641
Cardiac arrest 31.25 9.64 608 200262 171488 79372030
Lower respiratory tract infection 31.15 9.64 194 200676 129026 79414492
Wheezing 30.86 9.64 170 200700 116494 79427024
Renal injury 30.49 9.64 103 200767 16824 79526694
Presyncope 30.24 9.64 192 200678 40862 79502656
Vulvovaginal burning sensation 30.05 9.64 28 200842 1589 79541929
Anhedonia 29.85 9.64 94 200776 14804 79528714
Haemophagocytic lymphohistiocytosis 29.72 9.64 9 200861 21828 79521690
Post cholecystectomy syndrome 29.55 9.64 16 200854 376 79543142
Hypomagnesaemia 29.52 9.64 211 200659 46700 79496818
Product substitution issue 29.49 9.64 115 200755 20141 79523377
Malignant neoplasm progression 29.35 9.64 211 200659 135779 79407739
Pain 29.24 9.64 1462 199408 702340 78841178
Malignant spinal cord compression 29.20 9.64 12 200858 147 79543371
Cardiac disorder 28.58 9.64 272 200598 65485 79478033
Cardiogenic shock 28.42 9.64 192 200678 41722 79501796
Device dislocation 28.33 9.64 15 200855 25955 79517563
Vasculitic rash 28.10 9.64 31 200839 2153 79541365
Therapy partial responder 27.97 9.64 5 200865 17392 79526126
Arteriosclerosis 27.78 9.64 105 200765 18122 79525396
Intentional product misuse 27.23 9.64 135 200735 95030 79448488
Knee arthroplasty 26.92 9.64 42 200828 43206 79500312
COVID-19 pneumonia 26.87 9.64 20 200850 28829 79514689
Hyperglycaemia 26.74 9.64 283 200587 70052 79473466
Gastrointestinal disorder 26.67 9.64 189 200681 122016 79421502
Arteriosclerosis coronary artery 26.63 9.64 102 200768 17714 79525804
Multiple fractures 26.59 9.64 61 200809 7965 79535553
Nodal rhythm 26.51 9.64 36 200834 3099 79540419
Premature delivery 26.43 9.64 13 200857 23454 79520064
Pacemaker generated rhythm 26.20 9.64 9 200861 64 79543454
Angioedema 26.18 9.64 300 200570 75735 79467783
Blood glucose decreased 26.12 9.64 133 200737 26101 79517417
Dilatation atrial 26.12 9.64 39 200831 3665 79539853
Diabetic neuropathy 26.08 9.64 52 200818 6164 79537354
Atrioventricular block second degree 25.82 9.64 57 200813 7255 79536263
Incorrect route of product administration 25.71 9.64 30 200840 34899 79508619
Disease progression 25.65 9.64 319 200551 184043 79359475
Hypovolaemia 25.40 9.64 100 200770 17591 79525927
Hyperhidrosis 25.11 9.64 528 200342 150964 79392554
Red blood cell count decreased 25.04 9.64 238 200632 57275 79486243
Hip arthroplasty 24.96 9.64 32 200838 35724 79507794
Cardiomegaly 24.45 9.64 131 200739 26221 79517297
Inappropriate schedule of product administration 24.37 9.64 217 200653 133411 79410107
Sepsis 24.18 9.64 506 200364 268922 79274596
Rash 24.07 9.64 1201 199669 577157 78966361
Lacunar infarction 24.00 9.64 49 200821 5908 79537610
Plasmapheresis 23.98 9.64 17 200853 652 79542866
Duodenal ulcer 23.88 9.64 93 200777 16276 79527242
Change of bowel habit 23.84 9.64 32 200838 2725 79540793
Productive cough 23.75 9.64 128 200742 88203 79455315
Erectile dysfunction 23.62 9.64 86 200784 14578 79528940
Vulvovaginal pruritus 23.44 9.64 31 200839 2602 79540916
Lymphocyte count decreased 23.21 9.64 53 200817 47236 79496282
Acute coronary syndrome 23.08 9.64 110 200760 21023 79522495
Intracranial haematoma 22.94 9.64 19 200851 921 79542597
Weight increased 22.87 9.64 528 200342 276858 79266660
Helicobacter infection 22.87 9.64 94 200776 69610 79473908
Laryngospasm 22.54 9.64 38 200832 3959 79539559
Drug hypersensitivity 22.45 9.64 577 200293 298339 79245179
Tongue oedema 22.38 9.64 53 200817 7064 79536454
Confusion postoperative 22.33 9.64 11 200859 211 79543307
Carotid artery stenosis 22.10 9.64 60 200810 8698 79534820
Wrong drug 22.09 9.64 12 200858 284 79543234
Pregnancy 22.08 9.64 21 200849 26830 79516688
Gingival hypertrophy 22.03 9.64 33 200837 3109 79540409
Antiacetylcholine receptor antibody positive 21.95 9.64 8 200862 69 79543449
Therapy interrupted 21.93 9.64 28 200842 31313 79512205
Peripheral coldness 21.91 9.64 89 200781 15881 79527637
Cardiac valve disease 21.69 9.64 46 200824 5695 79537823
Paroxysmal atrioventricular block 21.40 9.64 6 200864 19 79543499
Vascular graft 21.39 9.64 26 200844 2005 79541513
Bronchopulmonary aspergillosis 21.36 9.64 15 200855 22279 79521239
Aspartate aminotransferase 21.33 9.64 15 200855 568 79542950
Hepatic function abnormal 21.32 9.64 103 200767 73004 79470514
Mitral valve incompetence 21.29 9.64 134 200736 28431 79515087
High density lipoprotein decreased 20.81 9.64 40 200830 4615 79538903
Neurotoxicity 20.80 9.64 31 200839 32487 79511031
Ulcer 20.74 9.64 138 200732 29834 79513684
Blood pressure decreased 20.70 9.64 359 200511 99107 79444411
Leukopenia 20.47 9.64 191 200679 116322 79427196
Bronchiectasis 20.24 9.64 16 200854 22370 79521148
Blood immunoglobulin A increased 20.18 9.64 18 200852 965 79542553
Disability 20.09 9.64 91 200779 17029 79526489
International normalised ratio decreased 20.08 9.64 55 200815 8015 79535503
Musculoskeletal stiffness 20.00 9.64 315 200555 174693 79368825
Liver function test increased 19.99 9.64 44 200826 39729 79503789
Cytomegalovirus viraemia 19.94 9.64 4 200866 12817 79530701
Gastric ulcer 19.90 9.64 150 200720 33755 79509763
Medication error 19.81 9.64 262 200608 68380 79475138
Swelling face 19.81 9.64 270 200600 70942 79472576
BRASH syndrome 19.66 9.64 18 200852 999 79542519
Dyskinesia oesophageal 19.56 9.64 7 200863 57 79543461
Phaeochromocytoma 19.52 9.64 15 200855 652 79542866
Hypophagia 19.39 9.64 187 200683 45180 79498338
Pathogen resistance 19.36 9.64 6 200864 14336 79529182
Diabetes mellitus 19.33 9.64 291 200579 78099 79465419
Grip strength decreased 19.31 9.64 16 200854 21853 79521665
Optic ischaemic neuropathy 19.22 9.64 30 200840 2931 79540587
Drop attacks 19.09 9.64 18 200852 1037 79542481
Skull fracture 19.09 9.64 23 200847 1757 79541761
Femur fracture 18.89 9.64 164 200706 38488 79505030
Rheumatoid arthritis 18.85 9.64 391 200479 208079 79335439
Nodal arrhythmia 18.72 9.64 24 200846 1954 79541564
Ischaemic cardiomyopathy 18.70 9.64 52 200818 7643 79535875
Muscle spasticity 18.61 9.64 16 200854 21459 79522059
Anxiety 18.51 9.64 784 200086 247728 79295790
Haemoglobin decreased 18.46 9.64 709 200161 221410 79322108
Abnormal dreams 18.45 9.64 67 200803 11345 79532173
Haematotoxicity 18.40 9.64 8 200862 15511 79528007
Renal artery stenosis 18.19 9.64 32 200838 3450 79540068
Phaeochromocytoma crisis 18.03 9.64 11 200859 326 79543192
Pneumocystis jirovecii pneumonia 18.01 9.64 34 200836 32474 79511044
Bradyarrhythmia 17.77 9.64 35 200835 4111 79539407
Impaired quality of life 17.73 9.64 7 200863 14379 79529139
Sleep disorder due to a general medical condition 17.51 9.64 7 200863 14270 79529248
Sinus arrhythmia 17.50 9.64 24 200846 2086 79541432
Deep vein thrombosis postoperative 17.48 9.64 3 200867 10749 79532769
Guillain-Barre syndrome 17.44 9.64 56 200814 8909 79534609
Prescribed overdose 17.37 9.64 44 200826 37839 79505679
Device difficult to use 17.36 9.64 6 200864 13379 79530139
Blood urine 17.23 9.64 16 200854 904 79542614
Coma scale normal 17.18 9.64 4 200866 4 79543514
Rectosigmoid cancer 17.12 9.64 10 200860 273 79543245
Glomerular filtration rate increased 17.00 9.64 18 200852 1193 79542325
Post transplant lymphoproliferative disorder 16.97 9.64 4 200866 11460 79532058
Ventricular dysfunction 16.97 9.64 43 200827 5980 79537538
Pulse absent 16.91 9.64 60 200810 10043 79533475
Hyperlactacidaemia 16.88 9.64 41 200829 5554 79537964
Supraventricular extrasystoles 16.77 9.64 47 200823 6940 79536578
Laryngeal pain 16.55 9.64 43 200827 6071 79537447
Arrhythmia 16.51 9.64 231 200639 61041 79482477
Pruritus 16.49 9.64 819 200051 393829 79149689
Encapsulating peritoneal sclerosis 16.33 9.64 15 200855 836 79542682
Paraplegia 16.29 9.64 38 200832 5015 79538503
Influenza 16.29 9.64 229 200641 129377 79414141
Hiatus hernia 15.93 9.64 107 200763 23205 79520313
Total lung capacity increased 15.92 9.64 24 200846 2274 79541244
Blood triglycerides increased 15.87 9.64 99 200771 20941 79522577
Ear infection 15.78 9.64 40 200830 34392 79509126
Vertigo 15.72 9.64 253 200617 68829 79474689
Cytopenia 15.56 9.64 17 200853 20366 79523152
Oral candidiasis 15.54 9.64 32 200838 29596 79513922
Tenosynovitis 15.53 9.64 10 200860 15544 79527974
Peripheral vascular disorder 15.48 9.64 50 200820 7980 79535538
Furuncle 15.44 9.64 48 200822 7506 79536012
Female orgasmic disorder 15.42 9.64 5 200865 29 79543489
Rhinalgia 15.39 9.64 24 200846 2343 79541175
Rectal haemorrhage 15.38 9.64 274 200596 76026 79467492
Potentiating drug interaction 15.30 9.64 53 200817 8766 79534752
Vitamin B12 increased 15.23 9.64 17 200853 1196 79542322
Mental status changes postoperative 15.21 9.64 8 200862 177 79543341
Epistaxis 15.15 9.64 378 200492 111137 79432381
Haemorrhoids 14.98 9.64 125 200745 29003 79514515
Urethral repair 14.96 9.64 3 200867 0 79543518
Cardiac stress test abnormal 14.89 9.64 14 200856 804 79542714
Purple glove syndrome 14.86 9.64 9 200861 263 79543255
Urine odour abnormal 14.86 9.64 42 200828 6231 79537287
Autoimmune disorder 14.86 9.64 12 200858 16600 79526918
Urinary incontinence 14.80 9.64 163 200707 40746 79502772
Haemorrhagic stroke 14.71 9.64 61 200809 10985 79532533
Toxic epidermal necrolysis 14.70 9.64 60 200810 44521 79498997
Liver injury 14.69 9.64 83 200787 56531 79486987
Feeling abnormal 14.64 9.64 514 200356 158685 79384833
Bone erosion 14.63 9.64 14 200856 17833 79525685
Respiratory tract infection 14.55 9.64 68 200802 48621 79494897
Unresponsive to stimuli 14.50 9.64 209 200661 55579 79487939
Granulocyte count increased 14.43 9.64 17 200853 1268 79542250
Lid lag 14.42 9.64 6 200864 76 79543442
Ischaemic stroke 14.37 9.64 137 200733 32994 79510524
Polyp 14.31 9.64 49 200821 8058 79535460
Infusion site pain 14.31 9.64 9 200861 14167 79529351
Vertigo positional 14.14 9.64 28 200842 3302 79540216
Bundle branch block left 14.11 9.64 62 200808 11451 79532067
Rheumatoid factor increased 14.04 9.64 20 200850 1801 79541717
Breast calcifications 13.99 9.64 14 200856 868 79542650
Coronary artery restenosis 13.97 9.64 17 200853 1312 79542206
Blood catecholamines decreased 13.97 9.64 4 200866 14 79543504
Continuous haemodiafiltration 13.89 9.64 21 200849 1995 79541523
Multiple sclerosis 13.89 9.64 100 200770 22182 79521336
Adjustment disorder with depressed mood 13.79 9.64 3 200867 9083 79534435
Tricuspid valve incompetence 13.79 9.64 91 200779 19621 79523897
Neurofibrosarcoma 13.78 9.64 8 200862 216 79543302
Upper respiratory tract infection 13.73 9.64 155 200715 91013 79452505
Clostridium difficile infection 13.73 9.64 58 200812 42627 79500891
Azotaemia 13.73 9.64 49 200821 8227 79535291
Inappropriate antidiuretic hormone secretion 13.57 9.64 113 200757 26200 79517318
Hepatitis acute 13.57 9.64 76 200794 15466 79528052
Purpura senile 13.53 9.64 11 200859 519 79542999
Laryngotracheal oedema 13.53 9.64 5 200865 45 79543473
White blood cell count decreased 13.46 9.64 366 200504 187922 79355596
Iron deficiency 13.44 9.64 5 200865 10649 79532869
Low density lipoprotein increased 13.41 9.64 50 200820 8572 79534946
Ankylosing spondylitis 13.39 9.64 7 200863 12198 79531320
Bundle branch block right 13.35 9.64 60 200810 11191 79532327
Stoma site haemorrhage 13.26 9.64 20 200850 1896 79541622
Coma scale abnormal 13.23 9.64 50 200820 8628 79534890
Pancytopenia 13.23 9.64 317 200553 165428 79378090
Idiopathic interstitial pneumonia 13.21 9.64 8 200862 234 79543284
Ventricular extrasystoles 13.20 9.64 90 200780 19614 79523904
Blood sodium decreased 13.20 9.64 135 200735 33120 79510398
Coronary artery thrombosis 13.05 9.64 26 200844 3080 79540438
Peak expiratory flow rate decreased 13.03 9.64 12 200858 671 79542847
Retinal vein thrombosis 13.00 9.64 12 200858 673 79542845
Herpes zoster 12.96 9.64 161 200709 92922 79450596
Haemorrhagic vasculitis 12.83 9.64 6 200864 102 79543416
Lip dry 12.75 9.64 12 200858 15406 79528112
Sputum discoloured 12.71 9.64 22 200848 21721 79521797
Drug dispensed to wrong patient 12.69 9.64 12 200858 694 79542824
Illness anxiety disorder 12.65 9.64 8 200862 253 79543265
Neuroleptic malignant syndrome 12.64 9.64 32 200838 27527 79515991
Hallucination, visual 12.58 9.64 132 200738 32597 79510921
Acute myeloid leukaemia 12.57 9.64 38 200832 30847 79512671
Respiratory syncytial virus infection 12.57 9.64 4 200866 9398 79534120
Haematemesis 12.49 9.64 193 200677 52071 79491447
Conjunctivitis 12.47 9.64 29 200841 25686 79517832
Genitourinary symptom 12.43 9.64 8 200862 261 79543257
Inflammation 12.37 9.64 164 200706 93589 79449929
Enterocolitis 12.35 9.64 11 200859 14501 79529017
Cerebral haemorrhage 12.30 9.64 209 200661 57464 79486054
Spermatozoa progressive motility decreased 12.26 9.64 5 200865 60 79543458
Duodenitis 12.23 9.64 46 200824 7921 79535597
Appendicitis 12.19 9.64 21 200849 20773 79522745
Wrong technique in product usage process 12.17 9.64 123 200747 73752 79469766
Sinoatrial block 12.17 9.64 16 200854 1335 79542183
Vitreous detachment 12.11 9.64 21 200849 2238 79541280
Cystitis haemorrhagic 12.09 9.64 4 200866 9168 79534350
Coronary artery surgery 12.09 9.64 7 200863 188 79543330
Swollen tongue 12.08 9.64 162 200708 42408 79501110
Depressed level of consciousness 12.07 9.64 324 200546 96328 79447190
Impaired healing 12.06 9.64 152 200718 87503 79456015
Hypogammaglobulinaemia 12.03 9.64 9 200861 12942 79530576
Mobility decreased 11.99 9.64 226 200644 121949 79421569
Adrenal insufficiency 11.96 9.64 117 200753 28370 79515148
Limb discomfort 11.94 9.64 131 200739 32719 79510799
Red blood cell sedimentation rate abnormal 11.89 9.64 92 200778 20871 79522647
Myocarditis 11.80 9.64 23 200847 21710 79521808
Cystocele 11.73 9.64 12 200858 764 79542754
Postoperative wound infection 11.73 9.64 64 200806 12897 79530621
Muscular weakness 11.72 9.64 506 200364 160223 79383295
Hepatic steatosis 11.72 9.64 146 200724 37592 79505926
Cold sweat 11.70 9.64 84 200786 18615 79524903
Facet joint syndrome 11.65 9.64 7 200863 11295 79532223
Night sweats 11.64 9.64 80 200790 52015 79491503
Substance abuse 11.60 9.64 6 200864 10520 79532998
Dialysis 11.59 9.64 83 200787 18379 79525139
Nitritoid reaction 11.58 9.64 4 200866 29 79543489
Vision blurred 11.56 9.64 349 200521 105549 79437969
Drug dependence 11.56 9.64 58 200812 40711 79502807
Abortion spontaneous 11.52 9.64 37 200833 29470 79514048
Entropion 11.51 9.64 5 200865 71 79543447
Pneumonia fungal 11.48 9.64 7 200863 11203 79532315
Bone disorder 11.47 9.64 85 200785 19028 79524490
Acne 11.40 9.64 33 200837 27157 79516361
Dystrophic calcification 11.40 9.64 6 200864 133 79543385
Tarsal tunnel syndrome 11.37 9.64 10 200860 526 79542992
Myositis 11.36 9.64 85 200785 19083 79524435
Peripheral venous disease 11.35 9.64 14 200856 15895 79527623
Spermatozoa progressive motility abnormal 11.35 9.64 4 200866 31 79543487
Injection site reaction 11.34 9.64 86 200784 54699 79488819
BK virus infection 11.33 9.64 4 200866 8800 79534718
Barrett's oesophagus 11.31 9.64 12 200858 797 79542721
Hallucination, auditory 11.28 9.64 90 200780 20603 79522915
Cutaneous lupus erythematosus 11.28 9.64 24 200846 2979 79540539
Sickle cell anaemia with crisis 11.27 9.64 3 200867 7919 79535599
Labile hypertension 11.17 9.64 10 200860 539 79542979
Multiple sclerosis relapse 11.13 9.64 70 200800 46463 79497055
Heart rate abnormal 11.04 9.64 37 200833 6020 79537498
Gastritis 11.00 9.64 176 200694 47817 79495701
Nail pigmentation 10.90 9.64 8 200862 324 79543194
Wound infection 10.89 9.64 28 200842 23963 79519555
Itching scar 10.83 9.64 4 200866 36 79543482
Medical diet 10.82 9.64 3 200867 9 79543509
Systolic hypertension 10.80 9.64 11 200859 697 79542821
Spinal shock 10.73 9.64 4 200866 37 79543481
Injection site discomfort 10.72 9.64 33 200837 5133 79538385
Extrasystoles 10.70 9.64 42 200828 7377 79536141
Pancreatitis acute 10.67 9.64 180 200690 49424 79494094
Dementia Alzheimer's type 10.66 9.64 13 200857 1006 79542512
Cerebral ischaemia 10.62 9.64 56 200814 11139 79532379
Cardiac flutter 10.61 9.64 32 200838 4922 79538596
Adenovirus infection 10.59 9.64 4 200866 8443 79535075
Balance disorder 10.58 9.64 325 200545 98532 79444986
Prinzmetal angina 10.57 9.64 17 200853 1703 79541815
Thyrotoxic periodic paralysis 10.57 9.64 6 200864 155 79543363
Pericardial haemorrhage 10.56 9.64 30 200840 4465 79539053
Stridor 10.55 9.64 34 200836 5419 79538099
Jaundice 10.54 9.64 191 200679 53158 79490360
Fibromuscular dysplasia 10.54 9.64 7 200863 241 79543277
Iatrogenic injury 10.53 9.64 16 200854 1527 79541991
Intentional self-injury 10.46 9.64 44 200826 32375 79511143
Altered state of consciousness 10.45 9.64 66 200804 43756 79499762
Thrombotic microangiopathy 10.39 9.64 22 200848 20147 79523371
Cyanosis 10.37 9.64 103 200767 25079 79518439
Heavy menstrual bleeding 10.35 9.64 12 200858 13999 79529519
Gamma-glutamyltransferase abnormal 10.32 9.64 10 200860 596 79542922
Coronary artery reocclusion 10.30 9.64 6 200864 163 79543355
Vaginal discharge 10.29 9.64 3 200867 7460 79536058
Bone hyperpigmentation 10.28 9.64 4 200866 42 79543476
Pulmonary mass 10.26 9.64 38 200832 28996 79514522
Foot deformity 10.25 9.64 29 200841 24045 79519473
Lung disorder 10.24 9.64 142 200728 80415 79463103
Exaggerated startle response 10.20 9.64 4 200866 43 79543475
Halo vision 10.17 9.64 10 200860 607 79542911
Pseudopolyposis 10.15 9.64 5 200865 96 79543422
Chronic kidney disease 10.13 9.64 228 200642 65926 79477592
Liver function test abnormal 10.12 9.64 223 200647 64252 79479266
Abdominal compartment syndrome 10.11 9.64 16 200854 1581 79541937
Refusal of treatment by relative 10.11 9.64 11 200859 752 79542766
Immune reconstitution inflammatory syndrome 10.07 9.64 12 200858 13829 79529689
Faeces discoloured 10.06 9.64 115 200755 29012 79514506
Cerebrovascular disorder 9.97 9.64 26 200844 3679 79539839
Venous recanalisation 9.97 9.64 3 200867 13 79543505
Refusal of treatment by patient 9.96 9.64 47 200823 8944 79534574
Hypocalcaemia 9.96 9.64 179 200691 49745 79493773
Cerebellar haematoma 9.92 9.64 10 200860 626 79542892
Amyotrophic lateral sclerosis 9.90 9.64 17 200853 1798 79541720
Hydronephrosis 9.89 9.64 18 200852 17436 79526082
Gastric ulcer haemorrhage 9.87 9.64 47 200823 8980 79534538
Joint effusion 9.84 9.64 19 200851 17995 79525523
Ocular myasthenia 9.81 9.64 8 200862 379 79543139
Vocal cord polypectomy 9.79 9.64 3 200867 14 79543504
Ear pain 9.76 9.64 46 200824 32823 79510695
Injection site swelling 9.75 9.64 74 200796 47058 79496460
Cardiac output decreased 9.74 9.64 17 200853 1821 79541697
Sensitisation 9.71 9.64 24 200846 3287 79540231
Colorectal adenocarcinoma 9.69 9.64 8 200862 386 79543132
Vitamin B12 deficiency 9.65 9.64 40 200830 7201 79536317
Resorption bone increased 9.65 9.64 15 200855 1460 79542058

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07CB53 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07DB01 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS
Beta blocking agents, selective, thiazides and other diuretics
ATC C07FB03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
FDA MoA N0000000161 Adrenergic beta-Antagonists
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:66991 sympatholytic drug
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Angina pectoris indication 194828000
Chronic heart failure off-label use 48447003
Atrial fibrillation off-label use 49436004 DOID:0060224
Thyrotoxicosis off-label use 90739004 DOID:7997
Mitral valve prolapse off-label use 409712001
Diastolic heart failure off-label use 418304008 DOID:9775
Essential tremor off-label use 609558009 DOID:4990
Pheochromocytoma Adjunct Therapy off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Migraine Prevention off-label use
Anuria contraindication 2472002 DOID:2983
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Complete atrioventricular block contraindication 27885002
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hypochloremic alkalosis contraindication 70134007
Oliguria contraindication 83128009
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Raynaud's phenomenon contraindication 266261006
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
First Degree Atrioventricular Heart Block contraindication
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.92 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.30 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.80 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 8.75 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 5.93 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.62 CHEMBL
Urease Enzyme IC50 4.19 CHEMBL

External reference:

IDSource
4018460 VUID
N0000146784 NUI
D00235 KEGG_DRUG
1202 RXNORM
C0004147 UMLSCUI
CHEBI:55352 CHEBI
2TN PDB_CHEM_ID
CHEMBL24 ChEMBL_ID
DB00335 DRUGBANK_ID
D001262 MESH_DESCRIPTOR_UI
2249 PUBCHEM_CID
548 IUPHAR_LIGAND_ID
3801 INN_ID
50VV3VW0TI UNII
353 MMSL
4225 MMSL
d00004 MMSL
387506000 SNOMEDCT_US
87652004 SNOMEDCT_US
4018460 VANDF
001855 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0752 TABLET 50 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0752 TABLET 50 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0752 TABLET 50 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0753 TABLET 100 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0753 TABLET 100 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0753 TABLET 100 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0787 TABLET 25 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0787 TABLET 25 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0787 TABLET 25 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0218 TABLET 25 mg ORAL ANDA 19 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0218 TABLET 25 mg ORAL ANDA 19 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0231 TABLET 50 mg ORAL ANDA 19 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0231 TABLET 50 mg ORAL ANDA 19 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0757 TABLET 100 mg ORAL ANDA 19 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0378-0757 TABLET 100 mg ORAL ANDA 19 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 0591-5782 TABLET 50 mg ORAL ANDA 18 sections
Atenolol and Chlorthalidone HUMAN PRESCRIPTION DRUG LABEL 2 0591-5783 TABLET 100 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8026 TABLET 25 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8027 TABLET 50 mg ORAL ANDA 24 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8372 TABLET 25 mg ORAL ANDA 13 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8372 TABLET 25 mg ORAL ANDA 13 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8373 TABLET 50 mg ORAL ANDA 13 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8373 TABLET 50 mg ORAL ANDA 13 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7187 TABLET 25 mg ORAL ANDA 19 sections
ATENOLOL AND CHLORTHALIDONE HUMAN PRESCRIPTION DRUG LABEL 2 10135-733 TABLET 50 mg ORAL ANDA 21 sections
ATENOLOL AND CHLORTHALIDONE HUMAN PRESCRIPTION DRUG LABEL 2 10135-734 TABLET 100 mg ORAL ANDA 21 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-031 TABLET 50 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-126 TABLET 25 mg ORAL ANDA 18 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-127 TABLET 50 mg ORAL ANDA 17 sections
Atenolol HUMAN PRESCRIPTION DRUG LABEL 1 10544-134 TABLET 25 mg ORAL ANDA 17 sections