secretin human 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 2548 108153-74-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • secretin synthetic human
  • human secretin
  • Secretin (human)
  • Secretin (swine), 15-L-glutamic acid-16-glycine-
  • secretin
  • secretin human
A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)
  • Molecular weight: 3039.46
  • Formula: C130H220N44O40
  • CLOGP:
  • LIPINSKI: 3
  • HAC: 84
  • HDO: 51
  • TPSA: 1401.22
  • ALOGS: -4.76
  • ROTB: 105

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.16 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.73 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.41 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 4, 2002 FDA CHIRHOCLIN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V04CK01 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for pancreatic function
FDA Chemical/Ingredient N0000006078 Secretin
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006728 Hormones
FDA EPC N0000175813 Secretin-class Hormone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Secretin Stimulation Testing indication
Alcoholism contraindication 7200002
Alcoholic fatty liver contraindication 50325005 DOID:9452
Asthma contraindication 195967001 DOID:2841
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.4 acidic
pKa2 3.97 acidic
pKa3 4.31 acidic
pKa4 12.01 acidic
pKa5 12.16 acidic
pKa6 12.52 acidic
pKa7 12.61 acidic
pKa8 12.85 acidic
pKa9 12.99 acidic
pKa10 13.11 acidic
pKa11 13.21 acidic
pKa12 13.3 acidic
pKa13 13.36 acidic
pKa14 13.42 acidic
pKa15 13.61 acidic
pKa16 13.68 acidic
pKa17 13.74 acidic
pKa18 13.75 acidic
pKa19 13.82 acidic
pKa20 11.35 Basic
pKa21 10.93 Basic
pKa22 10.57 Basic
pKa23 10.15 Basic
pKa24 7.99 Basic
pKa25 5.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Secretin receptor GPCR AGONIST EC50 9.70 IUPHAR CHEMBL

External reference:

IDSource
D02021 KEGG_DRUG
4018115 VANDF
CHEBI:135913 CHEBI
CHEMBL1201488 ChEMBL_ID
3643 IUPHAR_LIGAND_ID
DB09532 DRUGBANK_ID
606396 RXNORM
16599 MMSL
19105 MMSL
5447 MMSL
64005 MMSL
d04161 MMSL
002121 NDDF
19205004 SNOMEDCT_US
426025009 SNOMEDCT_US
68622003 SNOMEDCT_US
C1659046 UMLSCUI
D012633 MESH_DESCRIPTOR_UI
CHEMBL3039582 ChEMBL_ID
9510 INN_ID
16158474 PUBCHEM_CID
A0426J905J UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ChiRhoStim HUMAN PRESCRIPTION DRUG LABEL 1 67066-005 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 16 ug INTRAVENOUS NDA 22 sections
ChiRhoStim 40 HUMAN PRESCRIPTION DRUG LABEL 1 67066-007 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 ug INTRAVENOUS NDA 22 sections