All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sultiame 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	2540	61-56-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulthiame sulphenyltame sulphenytame sulphthiame sulthiam sulthiamine sultiame sultiam trolone	Molecular weight: 290.35 Formula: C10H14N2O4S2 CLOGP: 0.03 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 97.54 ALOGS: -2.17 ROTB: 2

Drug dosage:

Dose	Unit	Route
0.40	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	93 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PRKDC,SIK2,STK33,SYK,TEK,TTK	29
kinase-selectivity-class	AURKA,AXL,GRK2,MAP2K6,PDK1,PDK2,TEK	7
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple-drug resistance	154.85	79.49	30	724	7746	90619947
Congenital cyst	140.18	79.49	14	740	14	90627679
Electroencephalogram abnormal	82.63	79.49	16	738	4080	90623613
Drug ineffective	79.84	79.49	75	679	1384223	89243470

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple-drug resistance	88.03	71.10	20	747	13215	110575317
Congenital cyst	81.53	71.10	8	759	8	110588524
Drug ineffective	81.43	71.10	73	694	1520467	109068065
Anticonvulsant drug level increased	77.99	71.10	14	753	2844	110585688
Electroencephalogram abnormal	73.07	71.10	15	752	6158	110582374

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Congenital cyst	22.53	20.12	3	10	3	113937

Pharmacologic Action:

Source	Code	Description
ATC	N03AX03	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Other antiepileptics
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
CHEBI has role	CHEBI:35623	anticonvulsant

Related Drugs by ATC class:

N03AX Other antiepileptics 18 drugs

beclamidebrivaracetamcannabidiolcarisbamatecenobamatefelbamatefenfluramineganaxolonelacosamidelamotriginelevetiracetamperampanel show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.0	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	8.05		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	6.43		CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	7.37		CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	8.22		CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	6.87		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	7.19		CHEMBL
Carbonic anhydrase	Enzyme		CAN_YEAST		Ki	5.99		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	8.05		CHEMBL
Alpha carbonic anhydrase	Enzyme		B5SU02_9CNID		Ki	7.34		CHEMBL
Carbonic anhydrase	Enzyme		C0IX24_9CNID		Ki	6.91		CHEMBL
Astrosclerin-3	Enzyme		A6YCJ1_9METZ		Ki	6.56		CHEMBL
Beta-carbonic anhydrase 1	Enzyme		MTCA1_MYCTU		Ki	5.29		CHEMBL
Delta carbonic anhydrase	Enzyme		Q5U9J1_THAWE		Ki	6.77		CHEMBL
Carbonic anhydrase 2	Enzyme		MTCA2_MYCTU		Ki	6.18		CHEMBL
Carbonic anhydrase	Enzyme		Q5TU56_ANOGA		Ki	6.58		CHEMBL
Carbonic anhydrase, alpha family	Enzyme		Q31FD6_HYDCU		Ki	6.37		CHEMBL
Carbonate dehydratase	Enzyme		B2V8E3_SULSY		Ki	8.11		CHEMBL

External reference:

ID	Source
D01787	KEGG_DRUG
CHEBI:32171	CHEBI
OSP	PDB_CHEM_ID
CHEMBL328560	ChEMBL_ID
C084593	MESH_SUPPLEMENTAL_RECORD_UI
DB08329	DRUGBANK_ID
10240	RXNORM
007045	NDDF
420672000	SNOMEDCT_US
50580004	SNOMEDCT_US
C0038807	UMLSCUI
5356	PUBCHEM_CID
1434	INN_ID
I00Q766CZ2	UNII
I00Q766CZ2	INXIGHT DRUGS

Pharmaceutical products:

None