sultiame Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2540 61-56-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulthiame
  • sulphenyltame
  • sulphenytame
  • sulphthiame
  • sulthiam
  • sulthiamine
  • sultiame
  • sultiam
  • trolone
  • Molecular weight: 290.35
  • Formula: C10H14N2O4S2
  • CLOGP: 0.03
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 97.54
  • ALOGS: -2.17
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AX03 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 8.05 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 7.37 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 6.43 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.87 CHEMBL
Carbonic anhydrase Unclassified Ki 6.91 CHEMBL
Delta carbonic anhydrase Unclassified Ki 6.77 CHEMBL
Carbonic anhydrase Enzyme Ki 5.99 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.19 CHEMBL
Alpha carbonic anhydrase Unclassified Ki 7.34 CHEMBL
Astrosclerin-3 Unclassified Ki 6.56 CHEMBL
Carbonic anhydrase Enzyme Ki 8.05 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 5.29 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 6.18 CHEMBL
Carbonic anhydrase Unclassified Ki 6.58 CHEMBL

External reference:

IDSource
C0038807 UMLSCUI
D01787 KEGG_DRUG
420672000 SNOMEDCT_US
10240 RXNORM
50580004 SNOMEDCT_US
007045 NDDF
CHEBI:32171 CHEBI
CHEMBL328560 ChEMBL_ID
I00Q766CZ2 UNII
1434 INN_ID
OSP PDB_CHEM_ID
DB08329 DRUGBANK_ID
5356 PUBCHEM_CID
C084593 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None