sultiame 🐢 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2540 61-56-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulthiame
  • sulphenyltame
  • sulphenytame
  • sulphthiame
  • sulthiam
  • sulthiamine
  • sultiame
  • sultiam
  • trolone
  • Molecular weight: 290.35
  • Formula: C10H14N2O4S2
  • CLOGP: 0.03
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 97.54
  • ALOGS: -2.17
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Congenital cyst 141.38 70.02 14 376 14 50604720
Small for dates baby 80.11 70.02 15 375 3490 50601244

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Congenital cyst 81.71 66.86 8 431 8 64498285

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Congenital cyst 21.64 20.41 3 10 3 84662

Pharmacologic Action:

SourceCodeDescription
ATC N03AX03 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐢 Veterinary Drug Use

None

🐢 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme Ki 8.05 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 6.43 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 7.37 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 6.87 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.19 CHEMBL
Carbonic anhydrase Enzyme Ki 5.99 CHEMBL
Carbonic anhydrase Enzyme Ki 8.05 CHEMBL
Alpha carbonic anhydrase Enzyme Ki 7.34 CHEMBL
Carbonic anhydrase Enzyme Ki 6.91 CHEMBL
Astrosclerin-3 Enzyme Ki 6.56 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 5.29 CHEMBL
Delta carbonic anhydrase Unclassified Ki 6.77 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 6.18 CHEMBL
Carbonic anhydrase Enzyme Ki 6.58 CHEMBL
Carbonic anhydrase, alpha family Unclassified Ki 6.37 CHEMBL
Carbonate dehydratase Enzyme Ki 8.11 CHEMBL

External reference:

IDSource
D01787 KEGG_DRUG
CHEBI:32171 CHEBI
OSP PDB_CHEM_ID
CHEMBL328560 ChEMBL_ID
C084593 MESH_SUPPLEMENTAL_RECORD_UI
DB08329 DRUGBANK_ID
I00Q766CZ2 UNII
5356 PUBCHEM_CID
10240 RXNORM
007045 NDDF
420672000 SNOMEDCT_US
50580004 SNOMEDCT_US
C0038807 UMLSCUI
1434 INN_ID

Pharmaceutical products:

None