sulprostone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandins | 2538 | 60325-46-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | mg | P |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Renal cortical necrosis | 101.83 | 94.33 | 10 | 63 | 120 | 63488829 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G02AD05 | GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS UTEROTONICS Prostaglandins |
| MeSH PA | D000019 | Abortifacient Agents |
| MeSH PA | D000020 | Abortifacient Agents, Nonsteroidal |
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D003271 | Contraceptive Agents, Female |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D008600 | Menstruation-Inducing Agents |
| MeSH PA | D012102 | Reproductive Control Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.5 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | GPCR | AGONIST | Ki | 7 | IUPHAR | ||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 9.46 | IUPHAR | ||||
| Prostaglandin E2 receptor EP4 subtype | GPCR | Ki | 5.11 | PDSP | |||||
| Prostaglandin F2-alpha receptor | GPCR | AGONIST | Ki | 6.70 | IUPHAR | ||||
| Prostaglandin E2 receptor EP1 subtype | GPCR | AGONIST | Ki | 7.70 | IUPHAR | ||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 9.20 | IUPHAR | ||||
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | EC50 | 9.38 | IUPHAR | ||||
| Prostaglandin E2 receptor EP1 subtype | GPCR | AGONIST | Ki | 7 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D02725 | KEGG_DRUG |
| C0075628 | UMLSCUI |
| CHEBI:135755 | CHEBI |
| CHEMBL1472830 | ChEMBL_ID |
| DB12708 | DRUGBANK_ID |
| C016767 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1919 | IUPHAR_LIGAND_ID |
| 4243 | INN_ID |
| 501Q5EQ1GM | UNII |
| 5312153 | PUBCHEM_CID |
| 005342 | NDDF |
| 713461008 | SNOMEDCT_US |
Pharmaceutical products:
None