DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
sulprostone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
prostaglandins
2538
60325-46-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
sulproston
sulprostone
Molecular weight: 465.56
Formula: C23H31NO7S
CLOGP: 0.18
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 130
ALOGS: -4.20
ROTB: 11
Drug dosage:
Dose
Unit
Route
0.50
mg
P
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Renal cortical necrosis
101.83
94.33
10
63
120
63488829
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
G02AD05
GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
UTEROTONICS
Prostaglandins
MeSH PA
D000019
Abortifacient Agents
MeSH PA
D000020
Abortifacient Agents, Nonsteroidal
MeSH PA
D003270
Contraceptive Agents
MeSH PA
D003271
Contraceptive Agents, Female
MeSH PA
D000080066
Contraceptive Agents, Hormonal
MeSH PA
D008600
Menstruation-Inducing Agents
MeSH PA
D012102
Reproductive Control Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.5
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin E2 receptor EP1 subtype
GPCR
P34995
PE2R1_HUMAN
AGONIST
Ki
7
IUPHAR
Prostaglandin E2 receptor EP3 subtype
GPCR
P43115
PE2R3_HUMAN
AGONIST
Ki
9.46
IUPHAR
Prostaglandin E2 receptor EP4 subtype
GPCR
P35408
PE2R4_HUMAN
Ki
5.11
PDSP
Prostaglandin F2-alpha receptor
GPCR
P43088
PF2R_HUMAN
AGONIST
Ki
6.70
IUPHAR
Prostaglandin E2 receptor EP1 subtype
GPCR
PE2R1_MOUSE
AGONIST
Ki
7.70
IUPHAR
Prostaglandin E2 receptor EP3 subtype
GPCR
PE2R3_MOUSE
AGONIST
Ki
9.20
IUPHAR
Prostaglandin E2 receptor EP3 subtype
GPCR
PE2R3_RAT
AGONIST
EC50
9.38
IUPHAR
Prostaglandin E2 receptor EP1 subtype
GPCR
PE2R1_RAT
AGONIST
Ki
7
IUPHAR
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External reference:
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ID
Source
005342
NDDF
1919
IUPHAR_LIGAND_ID
4243
INN_ID
501Q5EQ1GM
UNII
5312153
PUBCHEM_CID
713461008
SNOMEDCT_US
C0075628
UMLSCUI
C016767
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135755
CHEBI
CHEMBL1472830
ChEMBL_ID
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Pharmaceutical products:
None
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sulprostone