All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sulprostone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
prostaglandins	2538	60325-46-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulproston sulprostone	Molecular weight: 465.56 Formula: C23H31NO7S CLOGP: 0.18 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 130 ALOGS: -4.20 ROTB: 11

Drug dosage:

Dose	Unit	Route
0.50	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SYK,TEK,TGFBR1	24
kinase-selectivity-class	AXL,BRAF,GRK2,MAP2K6,TEK	5
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Renal cortical necrosis	159.62	87.32	16	74	287	90628070

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Renal cortical necrosis	154.64	92.97	16	71	508	110588704

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G02AD05	GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS UTEROTONICS Prostaglandins
MeSH PA	D000019	Abortifacient Agents
MeSH PA	D000020	Abortifacient Agents, Nonsteroidal
MeSH PA	D000080066	Contraceptive Agents, Hormonal
MeSH PA	D003270	Contraceptive Agents
MeSH PA	D003271	Contraceptive Agents, Female
MeSH PA	D008600	Menstruation-Inducing Agents
MeSH PA	D012102	Reproductive Control Agents

Related Drugs by ATC class:

G02AD Prostaglandins 5 drugs

carboprostdinoprostdinoprostonegemeprostmisoprostol

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.5	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin E2 receptor EP1 subtype	GPCR	P34995	PE2R1_HUMAN	AGONIST	Ki	7		IUPHAR
Prostaglandin E2 receptor EP3 subtype	GPCR	P43115	PE2R3_HUMAN	AGONIST	Ki	9.46		IUPHAR
Prostaglandin E2 receptor EP4 subtype	GPCR	P35408	PE2R4_HUMAN		Ki	5.11		PDSP
Prostaglandin F2-alpha receptor	GPCR	P43088	PF2R_HUMAN	AGONIST	Ki	6.70		IUPHAR
Prostaglandin E2 receptor EP1 subtype	GPCR		PE2R1_MOUSE	AGONIST	Ki	7.70		IUPHAR
Prostaglandin E2 receptor EP3 subtype	GPCR		PE2R3_MOUSE	AGONIST	Ki	9.20		IUPHAR
Prostaglandin E2 receptor EP3 subtype	GPCR		PE2R3_RAT	AGONIST	EC50	9.38		IUPHAR
Prostaglandin E2 receptor EP1 subtype	GPCR		PE2R1_RAT	AGONIST	Ki	7		IUPHAR

External reference:

ID	Source
D02725	KEGG_DRUG
C0075628	UMLSCUI
CHEBI:135755	CHEBI
CHEMBL1472830	ChEMBL_ID
DB12708	DRUGBANK_ID
C016767	MESH_SUPPLEMENTAL_RECORD_UI
1919	IUPHAR_LIGAND_ID
4243	INN_ID
501Q5EQ1GM	UNII
5312153	PUBCHEM_CID
005342	NDDF
713461008	SNOMEDCT_US
501Q5EQ1GM	INXIGHT DRUGS

Pharmaceutical products:

None